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Recent Longevity News for the seven days ending 11/17/10.  You should consult your doctor if you are taking any medications.

Oral Aloe Vera for Treatment of Diabetes Mellitus and Dyslipidemia (printer-friendly) - Medscape, 11/16/10 - "Five out of the seven studies that evaluated diabetes endpoints in humans showed significant reductions in fasting blood glucose after treatment with oral aloe vera in patients with diabetes or prediabetes;[21,22,24,25,28] the remaining two studies reported a trend toward decreased blood or plasma glucose concentrations in the aloe-treated groups.[26,27] Significant reductions in HbA1c—up to 22.6% of baseline—were seen in all three studies that evaluated this measure.[22,27,28] One of these studies reported improvements in fructosamine levels,[27] suggesting an improvement in average blood glucose levels over time" - See aloe vera products at iHerb.

Secondhand smoke exposure increases risk of hearing loss - Science Daily, 11/15/10 - "Former smokers were significantly more likely to have impaired hearing. The prevalence of low to mid frequency hearing loss among this group was 14%. And almost half (over 46%) had high frequency hearing loss (more than 25 decibels) ... Although the risk was not as strong among those who had never smoked, almost one in 10 (8.6%) had low to mid frequency hearing loss and one in four (26.6%) had high frequency hearing loss"

US scientists significantly more likely to publish fake research - Science Daily, 11/15/10 - "US scientists are significantly more likely to publish fake research than scientists from elsewhere, finds a trawl of officially withdrawn (retracted) studies ... A total of 788 papers had been retracted during this period. Around three quarters of these papers had been withdrawn because of a serious error (545); the rest of the retractions were attributed to fraud (data fabrication or falsification)"

Regular exercise reduces large number of health risks including dementia and some cancers, study finds - Science Daily, 11/15/10 - "Regular exercise can reduce around two dozen physical and mental health conditions and slow down how quickly the body ages ... Health conditions covered by the review include: cancer, heart disease, dementia, stroke, type 2 diabetes, depression, obesity and high blood pressure"

Natural compound shows promise against Huntington's disease - Science Daily, 11/15/10 - "Fisetin, a naturally occurring compound found in strawberries and other fruits and vegetables, slows the onset of motor problems and delays death in three models of Huntington's disease ... tested fisetin's effects in a mouse model of HD. HD mice develop motor defects early on and have much shorter life spans than normal control animals. When Maher and her team fed them fisetin, the onset of the motor defects was delayed, and their life span was extended by about 30 percent"

Trust hormone associated with happiness: Human study suggests new role for oxytocin - Science Daily, 11/15/10 - "women who show large increases in oxytocin when they are trusted also report being more satisfied with life and less depressed" - See See Oxytocin 6x5iu tablets at International Antiaging Systems.

HPV Vaccine: Not Just for Women? - US News and World Report, 11/10/10 - "the federal Advisory Committee on Immunization Practices is deliberating whether to issue a public recommendation that boys and men be vaccinated with Gardasil, the only HPV vaccine approved for that group, just as it's recommended for women" - Note: The author talks about several cancers but leaves out head and neck which I believe is the main reason for boys to get vaccinate with Gardasil.  I was given a 25% chance of survival six years ago from cancer of the tonsil that spread to the lymph nodes.  They believe it was caused by HPV.  Somehow I made it through that with just a 6 inch scar on my neck that's hardly noticeable but I went through a lot of agony with that operation, lost about 15 pounds from not being able to eat for a long time after the operation plus about 15 months with the doctors convinced it would return because I refused radiation and chemo plus it was a late stage III before the operation.  I still need to be very careful with eating meat because the muscle tissue they took from my tonsil area makes it difficult to swallow.  I mostly eat turkey meat balls for the protein portion of meals.  That may have been prevented by Gardasil.

Why chocolate protects against heart disease - Science Daily, 11/10/10 - "ate 75 grams of unsweetened chocolate with a cocoa content of 72 percent. To analyze what happened with the ACE enzyme, blood samples were taken in advance and then a half hour, one hour, and three hours afterward ... In the sample taken three hours afterward, there was a significant inhibition of ACE activity. The average was 18 percent lower activity than before the dose of cocoa, fully comparable to the effect of drugs that inhibit ACE and are used as a first-choice treatment for high blood pressure" - Note:  I find that ACE inhibitor theory hard to believe. The results of up to 57% reduction in heart disease was found with amounts of chocolate much less than that and it would seem that amount would have very little effect on blood pressure. Plus two recent studies showed blood pressures of 135/85 and 146/81 so lower is not necessarily better.

Fructose-rich beverages associated with increased risk of gout in women - Science Daily, 11/10/10 - "Compared with consumption of less than 1 serving per month, women who consumed one serving per day had a 74 percent increased risk of gout; and those with 2 or more servings per day had a 2.4 times higher risk ... Orange juice intake was also associated with risk of gout. Compared with women who consumed less than a glass (6 oz.) of orange juice per month, women who consumed 1 serving per day had a 41 percent higher risk of gout, and there was a 2.4 times higher risk with 2 or more servings per day"

Probiotics shorten diarrhea episodes, review suggests - Science Daily, 11/9/10 - "Giving probiotics in conjunction with rehydration fluids reduced the duration of diarrhea by around a day and reduced the risk of diarrhea lasting four or more days by 59%"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations - Br J Nutr. 2010 Nov 15:1-12 - "α-Lipoic acid (ALA) has been termed the 'ideal' antioxidant, a readily absorbed and bioavailable compound capable of scavenging a number of free radicals, and it has been used for treating diseases in which oxidative stress plays a major role ... We showed that ALA exhibited anti-inflammatory effects on both acute and chronic inflammations, and a strongly anti-oxidative potency on linoleic acid oxidation. Moreover, the administration of CAR induced oedema in the paws. ALA significantly inhibited the ability of CAR to induce: (1) the degree of acute inflammation, (2) the rise in MPx activity, (3) the increases of GST and iNOS activities and the amount of LPO and (4) the decreases of GPx, GR and SOD activities and the amount of GSH. In conclusion, these results suggest that the anti-inflammatory properties of ALA, which has a strong anti-oxidative potency, could be related to its positive effects on the antioxidant system in a variety of tissues in rats" - See alpha lipoic acid at Amazon.com.

Orange juice decreases low-density lipoprotein cholesterol in hypercholesterolemic subjects and improves lipid transfer to high-density lipoprotein in normal and hypercholesterolemic subjects - Nutr Res. 2010 Oct;30(10):689-94 - "normolipidemic (NC) and hypercholesterolemic (HCH) subjects ... consumed 750 mL/day OJ concentrate (1:6 OJ/water) for 60 days ... Orange juice consumption decreased low-density lipoprotein cholesterol (160 +/- 17 to 141 +/- 26 mg/dL, P < .01) in the HCH group but not in the NC group. HDL-cholesterol and triglycerides remained unchanged in both groups. Free-cholesterol transfer to HDL increased (HCH: 4.4 +/- 2 to 5.6 +/- 1%, NC: 3.2 +/- 2 to 6.2 +/- 1%, P< .05) whereas triglyceride (HCH 4.9 +/- 1 to 3.1 +/- 1%, NC 4.4 +/- 1 to 3.4 +/- 1%, P< .05) and phospholipid (HCH 21.6 +/- 2 to 18.6 +/- 3%, NC 20.2 +/- 2 to 18.4 +/- 2%, P < .05) transfers decreased in both groups. Cholesteryl-ester transfer decreased only in HCH (3.6 +/- 1 to 3.1 +/- 1%, P < .05), but not in NC" - Note:  750 ml is .79 quarts.  Seem like it might be a problem with weight gain.

Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers - Am J Clin Nutr. 2010 Nov 10 - "Throughout the three 4-wk periods, volunteers consumed daily 500 mL orange juice, 500 mL control drink plus hesperidin (CDH), or 500 mL control drink plus placebo (CDP) ... Diastolic blood pressure (DBP) was significantly lower after 4 wk consumption of orange juice or CDH than after consumption of CDP (P = 0.02), whereas microvascular endothelium-related reactivity was not significantly affected when measured after an overnight fast. However, both orange juice and CDH ingestion significantly improved postprandial microvascular endothelial reactivity compared with CDP (P < 0.05) when measured at the peak of plasma hesperetin concentration" - See hesperidin at Amazon.com and Natural Balance, Great Legs, 60 Capsules at iHerb.  Note:  This link went dead but I've been taking hesperidin for years for the HDL benefit::

  • High Levels of HDL Cholesterol Can Save Your Life - ABC News, 11/3/00 - "So how much HDL is enough? Current guidelines say 35 milligrams per deciliter of blood (mg/dl) is normal, but most cardiologists would prefer you to have an HDL count that’s twice that. “The higher the better,” says Gaziano. “Once you get over 60 mg/dl, it’s a strong positive factor in avoiding heart disease.” ... this will increase your HDL by 21 percent (or 10 to 20 points) within 4 weeks. “We’re not sure, but this effect may be due to a flavonoid in orange juice called hesperidin"

Protective effects of dehydroepiandrosterone on atherosclerosis in ovariectomized rabbits via alleviating inflammatory injury in endothelial cells - Atherosclerosis. 2010 Aug 3 - "The risk for atherosclerosis is increased in postmenopausal women. Dehydroepiandrosterone (DHEA) is postulated to have anti-atherogenic properties ... DHEA administration alleviates efficiently the early pathologic damage of atherosclerosis, increases the serum NO level, and up-regulates the endothelial cell estrogen receptor (ER) expression of ovariectomized rabbits. DHEA in vitro significantly promotes NO synthesis, suppresses MDA and MCP-1 secretion of endothelial cells, and decreases ICAM-1, VCAM-1 and E-selectin expression in HUVECs; neither selective ERα antagonist (methyl-piperidino-pyrazole, MPP) nor ERβ antagonist (R,R-tetrahydrochrysene, R,RTHC) can abolish these effects. Furthermore, DHEA reduces CCR2, LFA-1 and VLA-4 expression in U937 cells, which in turn inhibits the adherence of monocytes to the injured endothelial cells. DHEA significantly decreased the LPS-induced NF-κB transcription" - See DHEA at Amazon.com.

Effects of telmisartan added to Angiotensin-converting enzyme inhibitors on mortality and morbidity in hemodialysis patients with chronic heart failure a double-blind, placebo-controlled trial - J Am Coll Cardiol. 2010 Nov 16;56(21):1701-8 - "In hemodialysis patients, CHF is responsible for a high mortality rate ... At 3 years, telmisartan significantly reduced all-cause mortality (35.1% vs. 54.4%; p < 0.001), cardiovascular death (30.3% vs. 43.7%; p < 0.001), and hospital admission for CHF (33.9% vs. 55.1%; p < 0.0001). With Cox proportional hazards analysis, telmisartan was an independent determinant of all-cause mortality (hazard ratio [HR]: 0.51; 95% confidence interval [CI]: 0.32 to 0.82; p < 0.01), cardiovascular mortality (HR: 0.42; 95% CI: 0.38 to 0.61; p < 0.0001), and hospital stay for deterioration of heart failure (HR: 0.38; 95% CI: 0.19 to 0.51; p < 0.0001). Adverse effects, mainly hypotension, occurred in 16.3% of the telmisartan group versus 10.7% in the placebo group" - Note:  It makes me wonder if similar effects on mortality might be seen in people without kidney disease.  See my telmisartan as a first line treatment page.

Skin carotenoid levels in adult patients with psoriasis - J Eur Acad Dermatol Venereol. 2010 Nov - "Patients with psoriasis appear to have lower skin carotenoid counts than patients without psoriasis"

Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities - Proc Natl Acad Sci U S A. 2010 Nov 8 - "Bisphenol A (BPA) is a highly prevalent constituent of plastics that has been associated with diabetes, cardiovascular disease, and an increased risk of miscarriages in humans ... BPA exposure results in impaired chromosome synapsis and disruption of meiotic double-strand break repair (DSBR) progression. BPA carries an anti-estrogenic activity in the germline and results in germline-specific down-regulation of DSBR genes, thereby impairing maintenance of genomic integrity during meiosis. C. elegans therefore constitutes a model of remarkable relevance to mammals with which to assess how our chemical landscape affects germ cells and meiosis"

What Is the Optimal Blood Pressure in Patients After Acute Coronary Syndromes?: Relationship of Blood Pressure and Cardiovascular Events in the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction (PROVE IT-TIMI) 22 Trial - Circulation. 2010 Nov 8 - "The relationship between BP (systolic or diastolic) followed a J- or U-shaped curve association with primary, secondary, and individual outcomes, with increased events rates at both low and high BP values, both unadjusted and after adjustment for baseline variables, baseline C-reactive protein, and on-treatment average levels of low-density lipoprotein cholesterol. A nonlinear Cox proportional hazards model showed a nadir of 136/85 mm Hg (range 130 to 140 mm Hg systolic and 80 to 90 mm Hg diastolic) at which the incidence of primary outcome was lowest. The curve was relatively flat for systolic pressures of 110 to 130 mm Hg and diastolic pressures of 70 to 90 mm Hg. Conclusions- After acute coronary syndrome, a J- or U-shaped curve association existed between BP and the risk of future cardiovascular events, with lowest event rates in the BP range of approximately 130 to 140 mm Hg systolic and 80 to 90 mm Hg diastolic and a relatively flat curve for systolic pressures of 110 to 130 mm Hg and diastolic pressures of 70 to 90 mm Hg, which suggests that too low of a pressure (especially <110/70 mm Hg) may be dangerous" - Note:  This says 135/85 for lowest mortality.  Below study says 146/81.

  • J-curve revisited: an analysis of blood pressure and cardiovascular events in the Treating to New Targets (TNT) trial - Eur Heart J. 2010 Sep 16 - "The relationship between SBP or DBP and primary outcome followed a J-curve with increased event rates above and below the reference BP range, both unadjusted and adjusted (for baseline covariates, treatment effect, and LDL levels). A time-dependent, non-linear, multivariate Cox proportional hazard model identified a nadir of 146.3/81.4 mmHg where the event rate was lowest. A similar non-linear relationship with a higher risk of events at lower pressures was found for most of the secondary outcomes of all-cause mortality, cardiovascular mortality, non-fatal MI, or angina. However, for the outcome of stroke, lower was better for SBP. Conclusion In patients with CAD, a low BP (<110-120/<60-70 mmHg) portends an increased risk of future cardiovascular events (except stroke)"

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