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Anti-aging Research > Ginseng
News & Research:
Wisconsin Ginseng (Panax
quinquefolius) to Improve Cancer-Related Fatigue - Medscape, 9/27/13 -
"cancer-related fatigue (CRF) ... A multisite,
double-blind trial randomized fatigued cancer survivors to 2000mg of
American ginseng vs a placebo for 8 weeks ... Multidimensional Fatigue
Symptom Inventory–Short Form (MFSI-SF) ... A statistically significant
difference was seen at 8 weeks with a change score of 20 (SD = 27) for the
ginseng group and 10.3 (SD = 26.1) for the placebo group (P = .003). Greater
benefit was reported in patients receiving active cancer treatment vs those
who had completed treatment. Toxicities per self-report and CTCAE grading
did not differ statistically significantly between arms" - See
ginseng products at iHerb.
Korean Ginseng Berry
Extract Effect on Sexual Function in ED - Medscape, 5/6/13 -
"were administered 4 tablets of either standardized
Korean ginseng berry (SKGB, 350 mg ginseng berry extract per tablet), or
placebo, daily, for 8 weeks. Efficacy was assessed with the International
Index of Erectile Function (IIEF)-15 and premature ejaculation diagnostic
tool (PEDT) at the end of the 4th and 8th week. We observed that the total
and each of the individual domain scores of IIEF-15 increased from
40.95+/-7.05 to 46.19+/-12.69 significantly in the SKGB by the 8th week
(P<0.05). The erectile function domain of IIEF changed slightly from
17.17+/-2.57 to 18.59+/-5.99 in the SKGB group by the 8th week (P<0.05). In
addition, PEDT scores significantly improved from 9.14+/-4.57 to 7.97+/-4.4 and
7.53+/-4.26 in the SKGB group after 4 and 8 weeks of treatment (P<0.05).
Safety markers including hormone and lipid in the blood were assessed at the
end of the 4th and 8th week and they remained unchanged. Oral administration
of the SKGB extract improved all domains of sexual function"
Ginseng May Banish Cancer Fatigue, New Study Finds - ABC News, 6/4/12 -
"Researchers gave 2,000 milligrams of pure ground
American ginseng or a placebo pill to 340 patients being treated for cancer
and cancer survivors who had finished their treatment. After four weeks,
patients reported little change in their cancer-related fatigue. But after
eight weeks, the patients taking ginseng reported feeling generally more
energized than their sugar pill-popping peers. The response was particularly
strong among patients who were currently undergoing cancer treatment ...
Some studies have shown that ginseng decreases inflammation and the stress
hormone cortisol, both of which may be contributing factors to
cancer-related fatigue ... Extracts of ginseng that are alcohol based change
a characteristic of the ginseng to be somewhat estrogenic ... Stay with very
Natural aphrodisiacs: 'Spicing' up your love life possible, finds study of
ginseng and saffron - Science Daily, 3/28/11 -
"Ours is the most thorough scientific review to date. Nothing has been done
on this level of detail before now ... They found that panax ginseng,
saffron and yohimbine, a natural chemical from yohimbe trees in West Africa,
improved human sexual function ... People report increased sexual desire
after eating muira puama"
Best Treatment for Erectile Dysfunction? - Dr. Weil, 11/30/09 -
"Ginkgo ... Ashwaganda ... Asian ginseng
Ginseng: Nature's Anti-inflammatory? - Science Daily, 5/13/09 -
"The anti-inflammatory role of ginseng may be due to
the combined effects of these ginsenosides, targeting different levels of
immunological activity, and so contributing to the diverse actions of
ginseng in humans"
Ginseng May Help Treat Schizophrenia - WebMD, 5/8/08 -
"In a small study, patients had fewer negative
symptoms -- such as lack of motivation and a severe reduction in emotional
expression known as "flat affect" -- when they took Panax ginseng than when
they took a placebo ... patients were 50% less likely to have flat affect
when taking the higher, 200-milligram dose of ginseng than when taking
Ginseng May Relieve Cancer Fatigue - WebMD, 6/4/07
Shows Potential To Reduce Cancer-related Fatigue - Science Daily, 6/3/07
- "Of the four treatment arms,
patients receiving the placebo and the lowest dose of ginseng reported very
little improvement in fatigue or other areas of physical or psychological
well-being. The patients receiving the larger doses showed improvements in
overall energy levels, reporting higher vitality levels and less
interference with activity from fatigue. They also reported an improvement
in overall mental, physical, spiritual and emotional well-being"
Ginseng, Ginko Biloba Do Not Interfere With Drug Absorption If Taken At
Recommended Doses - Science Daily, 5/1/07 -
"found daily use of ginseng or
ginkgo biloba supplements at the recommended doses, or the combination of
both supplements, are unlikely to alter the pharmacokinetics - by which
drugs are absorbed, distributed, metabolized, and eliminated by the body -
of the majority of prescription or over-the counter drugs"
Ginseng linked to improved breast cancer outcomes - Nutra USA, 8/17/06
Product Review of Ginseng Supplements - ConsumerLab.com, 5/12/06
Researchers Find Ginseng May Improve Breast Cancer Outcomes - Science
Daily, 3/16/06 - "They also found
significant improvements in both survival and quality of life measures in
patients who used ginseng"
Cortisol, Stress, and Health
- Life Extension Magazine, 12/05 -
"Supplements to reduce high
cortisol levels secondary to stress ...
Vitamin C: 1000-3000 mg/day ... Fish oil (omega-3
fatty acids):1-4 gm/day ... Phosphatidylserine:
300-800 mg/day ... Rhodiola rosea:
100-200 mg/day, standardized extract ... Ginseng: 100-300 mg/day,
standardized extract ... Ginkgo biloba: 100-200
mg/day, standardized extract ... DHEA: 25-50
mg/day (any hormone supplementation should be monitored by your physician)"
Reduce Number and Severity of Colds - New York Times, 11/1/05
Ginseng for Gesundheit? Latest Study on Colds - WebMD, 10/24/05 -
"one in 10 people in the ginseng
group reported having two or more colds that winter, compared with about 23%
of those taking the placebo ... Colds lasted about 11 days for the ginseng
group and 16.5 days for the placebo group"
- MIT Team Explains Yin-yang Of Ginseng; Work Emphasizes Need For Stronger
Regulations Of Herbal Drugs - Science Daily,
- Ginseng a No-No for Patients on Coumadin - WebMD,
- Herbal Supplement Ginseng Reduces Effects Of Warfarin
- Doctor's Guide, 7/6/04
Natural Sex Boosters Gaining Ground - WebMD, 5/5/04
- Early Pregnancy Risk With Ginseng - WebMD, 9/24/03
- Ginseng review - ConsumerLab.com, 8/29/03 -
"A high amount of the pesticide hexachlorobenzene
— a potential human carcinogen — was found in one of five products labeled as
containing "Korean Ginseng." Levels of two other pesticides,
— were also above acceptable levels. Another product that failed the new
testing was a liquid "Chinese Ginseng" sold in single-dose bottles. Despite
being labeled "EXTRA STRENGTH" this product contained less than 10% of the
- Ginseng May Improve Glucose Control - Doctor's
- Ginseng May Help Treat Diabetes - WebMD, 6/16/03 -
"There are two reasons blood sugar can be out of control in [people with
diabetes] ... Your body's tissues are not responsive enough to insulin
so they don't process it properly and/or you don't make enough insulin to
begin with ... Ginseng, he said, appears to help the patients both to
secrete more insulin and to process better the insulin they have" -
American ginseng products.
Red Ginseng Benefits Men with Impotence - New Hope
Natural Media, 1/2/03 - "Men
experiencing sexual difficulties due to
inability to achieve erection may be helped by Korean red ginseng (Panax
ginseng), according to a study published in the Journal of Urology ... It is
a problem that affects nearly half of men over age forty worldwide ... Some
60% of participants reported improved erections while receiving ginseng.
Improved sexual desire was also reported during ginseng treatment.
Testosterone levels did not change with treatment, leading the
researchers to conclude that improvements observed with ginseng are not due
to hormonal effects" - See
Korean (Panax) ginseng.
Ginseng May Help Regulate Blood Glucose - Natural Foods Merchandiser,
8/02 - "Three new studies, performed
jointly by researchers at the University of Toronto, St. Michael's Hospital
in Toronto and the University of Ottawa, show that American ginseng can
lower blood-sugar levels in diabetic and
nondiabetic patients" - See
American ginseng products.
- Ginseng's New Powers - HealthScout, 5/24/02
- Ginseng Berry Shows Promise for Diabetes - WebMD,
Ginseng: Fewer Adverse Events if Used Alone - Clinical Psychiatry News,
- Ginseng Helps Regulate Blood Glucose - Nutrition
Science News, Spring '02 - "Three
new studies, performed jointly by researchers at the University of Toronto,
St. Michael's Hospital in Toronto, and the University of Ottawa, show that
American ginseng can lower blood-sugar levels in
diabetic and nondiabetic
patients ... They found no significant differences between the three
doses—each lowered postprandial glucose levels an average of 11.4 percent"
- Some Herbs Boost Breast Cancer Risk - WebMD,
3/26/02 - "Our
studies show that dong quai and ginseng stimulate the growth of [breast
- Notoginseng Cuts Bleeding Time in Half - Nutrition
Science News, 12/01
Bright Future For Chinese Mountain Herb - Natural Foods Merchandiser,
- Ginseng Lowers Blood Glucose - Nutrition Science
- Not All Ginseng Supplements Are Alike - WebMD,
6/26/01 - "a
new analysis of 25 commercial ginseng products suggests that the actual
concentration of ginseng is lower than the label says about half the time
and in six products the concentration was only 1%"
Study: Supplement Can Help Take the 'Dys' Out of Female Sexual Dysfunction,
Researchers Promote Idea of 'Sexual Wellness' - WebMD, 6/5/01 -
"ArginMax -- a dietary cocktail consisting of
ginseng, ginkgo, B vitamins, calcium, folic acid, and other vitamins and
minerals -- is being heralded as one component of a lifestyle that improves
sexual performance and helps prevent problems associated with intimacy"
- Sustain the Brain - Nutrition Science News, 2/01
Beyond the Label: American Ginseng Protects - Nutrition Science News,
2/01 - "American ginseng has been
shown to display synergistic effects against breast cancer cell growth when
combined with chemotherapy. From the protective perspective, American
ginseng displays potent antioxidant defenses against free radical damage to
human LDL cholesterol, which is reinforced by the vitamin C that inhabits
LDL. The most striking results attributable to this American root are found
in its ability to smooth out post-meal blood-sugar surges and carbohydrate
metabolism in both nondiabetics and type II diabetics."
- American Ginseng Protects - Nutrition Science
- Ginseng Laced With Pesticides - Nutrition Science
Saving Yourself from AGE - Life Enhancement Magazine, 8/00 -
with American Ginseng, "The
researchers found a reduction in plasma prolactin, a hormone connected with
passive "nesting" behavior, suggesting that this may play a role in the
ability of American ginseng to stimulate sexual activity in the male rat."
Want a love potion? What to know before you try - CNN, 6/15/00 -
"Tissue and animal studies of one form of ginseng, called panax, give some
credence to the root's sexy reputation. A study published in the May 1995
issue of the journal British Pharmacology, for instance, concluded that
substances in ginseng extract known as ginsenosides may work in a similar
way to Viagra. Viagra enhances the effects of nitric oxide, which helps
relax artery walls, allowing more blood flow into the penis. Ginsenosides
may encourage the release of more nitric oxide."
Ginseng May Enhance Immune Function - WebMD, 6/5/00
- Stress: The Hidden Factor For Weight Gain -
Nutrition Science News, 4/01
Ergogenics for Endurance Athletes - Nutrition Science News, 3/00
Herbal Aids for Cancer - Nutrition Science News, 3/00
Be All That You Can Be - Life Enhancement Magazine, 7/99
- Chinese Herbs Enhance Sexual Vitality - Nutrition
Science News, 3/99
notoginseng Attenuates Experimental Colitis in the Azoxymethane/Dextran Sulfate
Sodium Mouse Model - Phytother Res. 2013 Oct 21 -
"Our data suggest that P. notoginseng is a promising candidate in preventing and
treating colitis and inflammation-associated colon carcinogenesis" - See
ginseng products at iHerb.
pseudoginseng - Wikipedia, the free encyclopedia -
"Panax notoginseng is a species of the genus Panax"
Rg3 improves cardiac mitochondrial population quality:mimetic exercise training
- Biochem Biophys Res Commun. 2013 Oct 15 - "Ginsenoside
Rg3 (Rg3), one of the active ingredients in Panax ginseng, is well known in
herbal medicine as a tonic and restorative agent ... In the present study, we
compared the effects of Rg3 administration with aerobic exercise on
mitochondrial adaptation in cardiac muscle tissue of Sprague-Dawley (SD) rats.
Three groups of SD rats were studied 1) sedentary control, 2) Rg3-treated and 3)
aerobic exercise trained ... Rg3 mimics improved cardiac adaptations to exercise
by regulating mitochondria dynamic remodeling and enhancing the quantity and
quality of mitochondria"
of fermented red ginseng on depression is mediated by lipids - Nutr Neurosci.
2013 Oct 1 - "The cortico-limbic
hypothalamic-pituitary-adrenal axis has emerged as an important area for the
cause and treatment of depression. The primary aim of this study was to test the
hypothesis that hormones, energy sources, and minerals have a causal
relationship with depression. The secondary aim was to test whether consumption
of fermented red ginseng (FRG) would influence that causal relationship ... One
group (49 women) was supplied with FRG capsules, and the other group (44 women)
with placebo capsules, for 2 weeks. Both before and after the study, the
participants filled out the Beck depression inventory questionnaire, and then
blood samples were collected ... cognitive depression (CD) and somatic
depression ... the effect of FRG consumption on CD occurred via the energy
factor, which is mainly attributable to cholesterol"
Ginseng (Panax quinquefolius) to Improve Cancer-Related Fatigue: A Randomized,
Double-Blind Trial, N07C2 - J Natl Cancer Inst. 2013 Jul 13 -
"A multisite, double-blind trial randomized fatigued
cancer survivors to 2000mg of American ginseng vs a placebo for 8 weeks ...
Three hundred sixty-four participants were enrolled from 40 institutions ...
Data support the benefit of American ginseng, 2000mg daily, on CRF over an
8-week period. There were no discernible toxicities associated with the
Ginsenoside Rg1 Supplementation Improves Age-Related Cognitive Decline by
Promoting Synaptic Plasticity Associated Protein Expression in C57BL/6J Mice
- J Gerontol A Biol Sci Med Sci. 2013 Jul 5 - "In aging
individuals, age-related cognitive decline is the most common cause of memory
impairment. Among the remedies, ginsenoside Rg1, a major active component of
ginseng, is often recommended for its antiaging effects ... This study employed
a scheme of Rg1 supplementation for female C57BL/6J mice, which started at the
age of 12 months and ended at 24 months, to investigate the effects of Rg1
supplementation on the cognitive performance. We found that Rg1 supplementation
improved the performance of aged mice in behavior test and significantly
upregulated the expression of synaptic plasticity-associated proteins in
hippocampus, including synaptophysin, N-methyl-d-aspartate receptor subunit 1,
postsynaptic density-95, and calcium/calmodulin-dependent protein kinase II
alpha, via promoting mammalian target of rapamycin pathway activation. These
data provide further support for Rg1 treatment of cognitive degeneration during
Korean ginseng berry extract on sexual function in men with erectile
dysfunction: a multicenter, placebo-controlled, double-blind clinical study
- Int J Impot Res. 2012 Dec 20 - "Ginseng is beneficial
for many aspects of human physiology, including sexual function ... administered
4 tablets of either standardized Korean ginseng berry (SKGB, 350 mg ginseng
berry extract per tablet), or placebo, daily, for 8 weeks. Efficacy was assessed
with the International Index of Erectile Function (IIEF)-15 and premature
ejaculation diagnostic tool (PEDT) at the end of the 4th and 8th week. We
observed that the total and each of the individual domain scores of IIEF-15
increased from 40.95+/-7.05 to 46.19+/-12.69 significantly in the SKGB by the 8th
Prevention and Immuno-Enhancement Mediated by Daily Consumption of a Proprietary
Extract from North American Ginseng by Elderly Mice of a Cancer-Prone Strain
- Phytother Res. 2012 Nov 7 - "We have previously shown in a leukemia-induced
tumor model (mouse) that a proprietary extract (CVT-E002), of North American
ginseng, administered in the diet, significantly increased the absolute numbers
of NK cells, significantly decreased leukemia cells and significantly increased
the life span of CVT-E002-fed leukemic mice. In the present study, we assessed
the efficacy of this extract to inhibit the spontaneous development of tumors in
elderly mice of the cancer-prone C3H strain. Dietary CVT-E002 was fed for
approximately a year beginning when mice were almost 2 years of age. Control
mice, consuming the same chow without CVT-E002, all developed assorted, palpable
tumors between 22 and 33 months, while all mice consuming CVT-E002 remained
alive and tumor-free until they were purposely euthanized as healthy animals.
The absolute numbers of NK cells at euthanasia, in CVT-E002-consuming mice, were
significantly elevated in both the spleen and bone marrow. Given these
profoundly positive results and the fact that CVT-E002 already exists in the
marketplace under the label Cold-fX®, the potential for cancer prevention in
humans becomes apparent" - See Cold FX, 300mg 168 Capsules.
Sun Ginseng on Memory Enhancement and Hippocampal Neurogenesis - Phytother
Res. 2012 Oct 29 - "Panax ginseng C.A. Meyer has been
used in traditional herb prescriptions for thousands of years. A heat-processing
method has been used to increase the efficacy of ginseng, yielding what is known
as red ginseng. In addition, recently, a slightly modified heat-processing
method was applied to ginseng, to obtain a new type of processed ginseng with
increased biological activity; this new form of ginseng is referred to as Sun
ginseng (SG) ... These results suggest that SG has memory-enhancing activities
and that these effects are mediated, in part, by the increase in the levels of
pERK and pAkt and by the increases in cell proliferation and cell survival"
effects of Korean red ginseng on lymphocyte DNA damage, antioxidant enzyme
activity, and LDL oxidation in healthy participants: a randomized, double-blind,
placebo-controlled trial - Nutr J. 2012 Jul 17;11(1):47 -
"KRG supplementation may attenuate lymphocyte DNA damage
and LDL oxidation by upregulating antioxidant enzyme activity"
Re rapidly reverses insulin resistance in muscles of high-fat diet fed rats
- Metabolism. 2012 May 7 - "Our results show that the
ginsenoside Re induces a remarkably rapid reversal of high-fat diet-induced
insulin resistance of muscle glucose transport by reversing the impairment of
insulin-stimulated GLUT4 translocation to the cell surface"
Synergistic Apoptotic Interaction of Panaxadiol and Epigallocatechin Gallate in
Human Colorectal Cancer Cells - Phytother Res. 2012 May 8 -
"Panaxadiol (PD) is a purified sapogenin of ginseng
saponins, which exhibits anticancer activity. Epigallocatechin gallate (EGCG), a
major catechin in green tea, is a strong botanical antioxidant ... Cell growth
was suppressed after treatment with PD (10 and 20 µm) for 48 h. When PD (10 and
20 µm) was combined with EGCG (10, 20, and 30 µm), significantly enhanced
antiproliferative effects were observed in both cell lines. Combining 20 µm of
PD with 20 and 30 µm of EGCG significantly decreased S-phase fractions of cells.
In the apoptotic assay, the combination of PD and EGCG significantly increased
the percentage of apoptotic cells compared with PD alone (p < 0.01). The
synergistic apoptotic effects were also supported by docking analysis, which
demonstrated that PD and EGCG bound in two different sites of the annexin V
protein. Data from this study suggested that apoptosis might play an important
role in the EGCG-enhanced antiproliferative effects of PD on human colorectal
Ginseng as a
Potential Novel Addition to the Antikeloid Weaponry - Phytother Res. 2012
Feb 8 - "Keloid scars are large protruding claw-shaped lesions that develop
beyond the confines of the wound and uniquely appears only in humans. For
thousands of years ginseng has been used in the traditional medicine in oriental
countries. It occupies a prominent position in the list of the best-selling
medicinal herbs in the world. Panax ginseng often called Asian or Korean
ginseng, is the most extensively used and the best grade of ginseng and the term
of 'ginseng' generally refers to Panax ginseng. Previous studies have revealed
that ginseng inhibits NF-kappa B, TGF-β, IL-6, ACE and MMP-2 and these factors
play a pivotal role in keloid formation pathogenesis. Therefore it could be
reasoned that ginseng could be effective for the treatment of the keloid scars.
Clinical studies by topical applications of iPanax notoginseng (800 µg/ml) are
Rg1 Promotes Glucose Uptake Through Activated AMPK Pathway in Insulin-resistant
Muscle Cells - Phytother Res. 2011 Dec 15 - "Ginsenoside
Rg1, a protopanaxatriols saponin, is one of the major active constituents from
Panax ginseng and possesses various biological activities ... chronic treatment
of insulin resulted in reduced glucose uptake in the muscle cells. The treatment
of ginsenoside Rg1 significantly enhanced glucose uptake in the differentiated
muscle cells and the relative abundance of GLUT4 through the adenosine-monophosphate-activated
protein kinase pathway. These results suggest that ginsenoside Rg1 improved the
insulin resistance in C2C12 muscle cells, which might be useful for prevention
of T2DM and metabolic syndromes" - See
(red ginseng) products at iHerb.
Ginseng (Panax ginseng) Improves Insulin Sensitivity in High Fat Fed Sprague-Dawley
Rats - Phytother Res. 2011 Oct 28 - "Many studies have documented that
ginseng has antidiabetic and antiobesity effects, but the mechanism of the
effects has not been elucidated. The aim of this study was to determine the
effect of Korean red ginseng (KRG, Panax ginseng) and investigate the mechanism
of antidiabetic and antiobesity effects in obese insulin resistant animal
models. Sprague-Dawley (SD) rats were divided into three groups: a control group
(group I) fed a normal diet, another group (group II) fed only high fat diet
(HFD) and a third group (group III) fed HFD with KRG (200 mg/kg, oral) for
18 weeks ... A significant weight reduction, especially fat mass reduction, was
observed in the KRG treated group. Increased insulin sensitivity was found in
the KRG treated group. We observed increased insulin signalling, increased
phosphorylation of IR, IRS-1, Akt, and membranous GLUT4 in muscle by Western
blotting assay. In conclusion, KRG may have antidiabetic and antiobesity effects
due to partly increased insulin sensitivity by increased adipokine and partly
enhanced insulin signalling" - See
(red ginseng) products at iHerb.
red ginseng supplementation on menopausal symptoms and cardiovascular risk
factors in postmenopausal women: a double-blind randomized controlled trial
- Menopause. 2011 Oct 24 - "The aim of this study was to evaluate the effects of
red ginseng (RG) on menopausal symptoms and cardiovascular risk factors in
postmenopausal women ... either an RG group (supplemented with 3 g of RG,
including 60 mg of ginsenosides, per day) or a placebo group for 12 weeks ...
Significant improvements in the Kupperman index (P = 0.032) and in the menopause
rating scale (P = 0.035) scores were observed in the RG group compared with the
placebo group. Total cholesterol (P = 0.009) and low-density lipoprotein
cholesterol (P = 0.015) significantly decreased in the group receiving RG. The
RG group also showed a significant decrease in carotid intima-media thickness (P
= 0.049). Serum estradiol levels were not influenced by RG supplementation"
(red ginseng) products at iHerb.
Action of Panax ginseng Roots in Hypercortisolism-induced Impairment of
Hippocampal Neurons in Male C57BL/6N Mice - Phytother Res. 2011
Aug;25(8):1242-5 - "An increasing number of people suffering from hypercortisolism are at risk of developing hippocampus impairment and mental
disorders. The aim of this study was to investigate whether the water extract of
Panax ginseng roots (GWE) could prevent hypercortisolism-induced adverse
consequences. Hypercortisolism was experimentally induced by repeated
corticosterone injection in male mice. Treatment with corticosterone alone
resulted in a significant decrease in hippocampus neurofilament light chain
(NF-L) protein expression and induced depression-like behavior. Serum
corticosterone was significantly increased in the corticosterone-treated mice.
Treatment with GWE (800 and 400 mg/kg) during corticosterone treatment reduced
or partially antagonized the effects induced by corticosterone toward the normal
values of the controls; however, it failed to normalize increased corticosterone
levels in corticosterone-treated mice. Overall, ginseng conclusively exhibited a
protective action against hypercortisolism-induced impairment of hippocampal
Ginseng Rhizome and Ginsenoside Ro on Testosterone 5α-Reductase and Hair
Re-growth in Testosterone-treated Mice - Phytother Res. 2011 May 2 -
"Extracts of red ginseng rhizome showed greater
dose-dependent inhibitory effects against testosterone 5α-reductase (5αR) when
compared with extracts of the main root. Ginsenoside Ro, the predominant
ginsenoside in the rhizome, and ginsenoside Rg(3) , a unique ginsenoside in red
ginseng, showed inhibitory activity against 5αR with IC(50) values of 259.4 and
86.1 µm, respectively. The rhizome of P. japonicus, which contains larger
amounts of ginsenoside Ro, also inhibited 5αR. Topical administration of
extracts of red ginseng rhizomes (2 mg/mouse) and ginsenoside Ro (0.2 mg/mouse)
to shaved skin inhibited hair re-growth suppression after shaving in the
testosterone-treated C57BL/6 mice. These results suggest that red ginseng
rhizomes containing both oleanane- and dammarane-type ginsenosides are a
promising raw material for cosmetic use. This is the first report that
ginsenoside Ro enhances in vivo hair re-growth based on their inhibitory
activity against 5αR in the androgenetic alopecia model"
Korean Red Ginseng (Panax ginseng C.A. Mayer) and Its Isolated Ginsenosides and
Polysaccharides on Arterial Stiffness in Healthy Individuals - Am J
Hypertens. 2010 Feb 4 - "Although preliminary, this study is the first to
demonstrate that KRG may improve arterial stiffness as measured by AI"
herbal combination, Etana, for enhancing erectile function: an efficacy and
safety study in animals - Int J Impot Res. 2009 Jun 4 -
"a new herbal combination called Etana that is
composed of five herbal extracts including Panax quinquelotius (Ginseng),
Eurycoma longifolia (Tongkat Ali), Epimedium grandiflorum (Horny goat weed),
Centella asiatica (Gotu Kola) and flower pollen extracts. Most of the
above-mentioned extracts have a long historical and traditional use for
erectile dysfunction (ED) ... penile erection index (PEI) ... At a 7.5 mg
kg(-1) single dose, the percentage of responding rats was 53+/-7 with a PEI
of 337+/-72 compared with 17+/-6 with a PEI of 30+/-10 for control animals.
This PEI was significantly (P<0.001) higher than each single component and
than the sum of any two herbal components of Etana. When compared with
sildenafil citrate, Etana induced more pronounced PEI than 0.36 mg kg(-1),
but similar to 0.71 mg kg(-1) of sildenafil. Furthermore, full acute and
sub-acute toxicity studies showed no toxic effects of Etana. In conclusion,
this study describes a new and safe combination of herbal components that
enhance erectile function in male rats"
of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose
homeostasis in an obese insulin-resistant rat model - Metabolism. 2009
Jan;58(1):8-15 - "We evaluated the antihyperglycemic
and antiobesity effects of ginsam, a component of Panax ginseng produced by
vinegar extraction, which is enriched in the ginsenoside Rg3 ...
Insulin-resistant rats treated with ginsam had lower fasting and
postprandial glucose concentrations compared with vehicle-treated rats.
Importantly, overall glucose excursion during the intraperitoneal 2-hour
glucose tolerance test decreased by 21.5% (P < .01) in the treated rats,
indicating improved glucose tolerance. Plasma insulin concentration was
significantly lower in ginsam-treated rats. These changes may be related to
increased glucose transporter 4 expression in skeletal muscle.
Interestingly, when the data from both ginsam-treated groups were combined,
body weight was 60% lower in the ginsam-treated rats than in the controls (P
< .01). Liver weight and serum alanine aminotransferase concentrations were
also lower in the ginsam-treated rats. These effects were associated with
increased peroxisome proliferator-activated receptor gamma expression and
adenosine monophosphate-activated protein kinase phosphorylation in liver
and muscle. Our data suggest that ginsam has distinct beneficial effects on
glucose metabolism and body weight control in an obese animal model of
insulin resistance by changing the expression of genes involved in glucose
and fatty acid metabolism" - See
Ginseng products at iHerb.
Panax Ginseng Enhances
Cognitive Performance in Alzheimer Disease - Alzheimer Dis Assoc Disord.
2008 Jun 17 - "ginseng group was treated with Panax
ginseng powder (4.5 g/d) for 12 weeks ... After ginseng treatment, the
cognitive subscale of ADAS and the MMSE score began to show improvements and
continued up to 12 weeks (P=0.029 and P=0.009 vs. baseline, respectively).
After discontinuing ginseng, the improved ADAS and MMSE scores declined to
the levels of the control group. These results suggest that Panax ginseng is
clinically effective in the cognitive performance of AD patients" -
Ginseng products at iHerb.
Combined effects of swim training and ginseng supplementation on exercise
performance time, ROS, lymphocyte proliferation, and DNA damage following
exhaustive exercise stress - Int J Vitam Nutr Res. 2007 Jul;77(4):289-96
- "These findings suggest that the combined effect
of swim training and ginseng supplementation sustain lymphocyte function in
the presence of reduced ROS production and DNA damage following acute
Botanical and dietary supplements for mood and anxiety in menopausal women
- Menopause. 2006 Dec 28 - "The one
randomized, controlled trial of ginseng in postmenopausal women reported
improvements in mood and anxiety"