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Anti-aging Research > Phosphatidylserine (PS)
News & Research:
nutrients to protect the aging brain - Science Daily, 4/15/15 -
"Two pilot studies showed that a combination of
phosphatidylserine and phosphatidic acid can help benefit memory, mood, and
cognitive function in the elderly (Lonza, 2014)"
food supplement fights degenerative brain disorders, study suggests -
Science Daily, 5/21/13 - "Widely available in pharmacies
and health stores, phosphatidylserine is a natural food supplement ... the same
supplement improves the functioning of genes involved in degenerative brain
disorders, including Parkinson's disease and Familial Dysautonomia (FD) ...Not
only did phosphatidylserine impact the gene associated with FD, but it also
altered the level of a total of 2400 other genes -- hundreds of which have been
connected to Parkinson's disease in previous studies ... The researchers believe
that the supplement may have a beneficial impact on a number of degenerative
diseases of the brain"
Novel Strategy to Restore Brain Cell Function
- Life Extension Magazine, 5/06 -
"Alzheimer’s patients taking 300 mg of phosphatidylserine daily performed
significantly better on standardized memory tests at the end of the 12-week
trial period than did the study participants who received placebo. Importantly,
those patients who were the least afflicted by dementia demonstrated the
greatest benefit from phosphatidylserine therapy. These results suggest that
beginning supplementation very early on, or perhaps even before the appearance
of symptoms, can help prevent age-related loss of memory and other cognitive
Cortisol, Stress, and Health
- Life Extension Magazine, 12/05 -
"Supplements to reduce high cortisol levels
secondary to stress ... Vitamin C: 1000-3000
mg/day ... Fish oil (omega-3 fatty
acids):1-4 gm/day ... Phosphatidylserine: 300-800 mg/day ...
Rhodiola rosea: 100-200 mg/day,
standardized extract ... Ginseng: 100-300
mg/day, standardized extract ... Ginkgo biloba:
100-200 mg/day, standardized extract ... DHEA:
25-50 mg/day (any hormone supplementation should be monitored by your
Cortisol - Keeping a Dangerous Hormone in Check - Life Extension
Magazine, 7/04 -
"Phosphatidylserine, DHEA, and ginkgo biloba all have been shown to reduce
the amount of cortisol produced during stressful events, and these stress
fighters can help retard the negative consequences of this hormone"
Stress and Cortisol Levels - Vitamin Research News, 2/04 -
"I want to reduce cortisol levels in my body ... Phosphatidylserine, 300 mg
per day, is a good choice"
Phospholipids: Versatile Nutraceutical Ingredients For Functional Foods
- Functional Foods & Nutraceuticals, 12/02 -
"Ryser concluded that PS yielded clinically significant benefit to 25 of the
27 children. PS improved attention, concentration, learning, behaviour and
academic performance, seemingly extending their level of benefit once they
on fish oil and other nutritional supplements. Those prescribed
methylphenidate (Ritalin) or other pharmaceuticals also seemed to derive
additional benefit from PS which also benefited the depression and anxiety
commonly seen in these children"
Using Complementary Treatments -
PsychiatricTimes.com, 11/15/02 - "Phosphatidylserine
is active at cell membranes, including synaptic membrane zones. Partial
improvement of learning and recall capacity was noted in subjects with
age-related cognitive decline"
- Stress, Cortisol and Health - Supplement Watch
Newsletter, 10/02 -
"several lines of evidence have converged to solidify the concept that
stress makes us fat (because of cortisol),
thins our bones (because of cortisol), shrinks our brains (because of
cortisol), suppresses our immune system (because of cortisol), saps our
energy levels (because of cortisol), and kills our sex drive (because of
cortisol) ... Take a daily multivitamin/multi-mineral supplement - because
vitamin C and B-complex vitamins are
needed for a proper stress response ... Chief among the supplements with
documented cortisol-controlling effects are
Magnolia bark, Theanine,
Epimedium, Ashwagandha and
Phosphatidylserine (PS) The Essential Brain Nutrient - Life Extension
Magazine, 9/02 - "Among its list of
functions, phosphatidylserine stimulates the release of
dopamine (a mood regulator that also control physical sensations, and
movement), increases the production of acetylcholine (necessary for learning
and memory), enhances brain glucose metabolism (the fuel used for brain
activity), reduces cortisol levels (a stress
hormone), and boosts the activity of nerve growth factor (NGF),
which oversees the health of cholinergic neurons"
- A Supplement
to Prevent Alzheimer’s - Dr. Weil, 8/20/02 -
"In theory, PS works by strengthening cell membranes thus protecting them
and their contents from damage, particularly from the stress hormone
Choline Precursors Lower Stroke Death and Disability Rates, Meta-analysis
Indicates - Doctor's Guide, 2/11/02 -
"Choline precursors are a group of molecules that get converted to
phospholipids in the brain. Phospholipids perform many functions, including
serving as crucial nerve cell membrane components and acting as
neurotransmitters. Choline precursors include drugs like lecithin and
citicoline ... Death and disability rate was 54.6 (611/1119) percent for
patients treated with choline precursors compared to 66.4 (561/844) percent
for those on placebo ... choline precursors might improve ischemic brain
damage in two ways, by neuroprotection or by enhancement of neurorepair
Phosphatidylserine Boosts Brain Function - Nutrition Science News, 3/01
- "Recent animal studies have now
compared PS taken from different sources (egg, soy and cow brain), and have
found injectable soy PS to be on par with cow brain PS"
The Latest from the American College of Sports Medicine - Nutrition
Science News, 9/00 - "It is
generally accepted that the enzyme creatine kinase is an indicator of cell
membrane damage and necrosis of the muscle fibers," says John Seifert, a
principal investigator at St. Cloud. "Our work shows that PS supplementation
results in significantly lower amounts of creatine kinase (CK) levels 24
hours after exercise. This implies that PS can help minimize muscle fiber
damage caused by muscular stress."
Enhancing Cognitive Function - Life Extension Magazine, 5/00 -
"It has been shown that PS can increase the number of neurotransmitter
receptors back to youthful levels."
phosphatidylserine/ phosphatidic acid complex (PAS) normalizes the stress
reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male
subjects: a randomized, placebo-controlled study - Lipids Health Dis. 2014
Jul 31;13(1):121 - "randomly allocated to one of three
study arms (placebo, PAS 200 and PAS 400 per day, respectively) ... Compared to
placebo, a supplementation with a daily dose of PAS 400 was effective in
normalizing the ACTH (p = 0.010), salivary (p = 0.043) and serum cortisol
responses (p = 0.035) to the TSST in chronically high but not in low stressed
subjects (all p > 0.05). Compared to placebo, supplementation with PAS 200 did
not result in any significant differences in these variables" - See phosphatidylserine at Amazon.com.
of phosphatidylserine-containing omega-3 fatty acids on memory abilities in
subjects with subjective memory complaints: a pilot study - Clin Interv
Aging. 2010 Nov 2;5:313-6 - "PS-omega-3 supplementation
resulted in 42% increase in the ability to recall words in the delayed
condition" - See phosphatidylserine at Amazon.com and
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
Phosphatidylserine Containing omega-3 Fatty Acids May Improve Memory Abilities
in Non-Demented Elderly with Memory Complaints: A Double-Blind
Placebo-Controlled Trial - Dement Geriatr Cogn Disord. 2010 Jun
3;29(5):467-474 - "The results indicate that PS-DHA may
improve cognitive performance in non-demented elderly with memory complaints.
Post-hoc analysis of subgroups suggests that participants with higher baseline
cognitive status were most likely to respond to PS-DHA" - See
Jarrow Max DHA at Amazon.comand
phosphatidylserine products at iHerb.
Effects of phosphatidylserine supplementation on exercising humans -
Sports Med. 2006;36(8):657-69 - "S-PtdSer 800 mg/day
reduced the cortisol response to overtraining during weight training while
improving feeling of well-being and decreasing perceived muscle soreness"
Effects of soy lecithin phosphatidic acid and phosphatidylserine complex
(PAS) on the endocrine and psychological responses to mental stress -
Stress. 2004 Jun;7(2):119-26 -
"These data provide initial evidence for a selective stress dampening effect
of PAS on the pituitary-adrenal axis, suggesting the potential of PAS in the
treatment of stress related disorders"
The influence of phosphatidylserine supplementation on mood and heart rate
when faced with an acute stressor - Nutr Neurosci. 2001;4(3):169-78 -
"In young adults, with neuroticism
scores above rather than below the median, the taking of 300mg PS each day
for a month was associated with feeling less stressed and having a better
Blunting by chronic phosphatidylserine administration of the stress-induced
activation of the hypothalamo-pituitary-adrenal axis in healthy men -
Eur J Clin Pharmacol. 1992;42(4):385-8 -
"chronic oral administration of
phosphatidylserine may counteract stress-induced activation of the
hypothalamo-pituitary-adrenal axis in man"
Effects of phosphatidylserine on the neuroendocrine response to physical
stress in humans - Neuroendocrinology. 1990 Sep;52(3):243-8 -
"Pretreatment with both 50 and 75 mg
BC-PS significantly blunted the ACTH and cortisol responses to physical
800 mg active phosphatidylserine has been show to
reduce cortisol by 30%. That's pretty significant. I feel that
if there were a prescription drug that did that, it would be a first line
treatment for Cushing's. I'm sure the medical establishment will argue
that there needs to be more studies. I agree, but who is going to pay for
the studies on something that is not patentable and doctors can't get the big
bucks to write a prescription for. Maybe the AMA will fund the study out
of the kindness or their heart. Yea, right!
Most PS sold is actually only 20% PS.
Cargil Bbioactives has 20%, 40% and 90% PS. I've got no affiliation
with them but feel that they have the best product. To get 800 mg active,
it's eight 500 mg capsules of the usual 20% PS products. With Leci-PS 20
(which is 20% PS), it's about a 2.38 teaspoons. It is expensive stuff.
Probably your best bet for phosphatidylserine is
Cushing's syndrome is caused by prolonged exposure of the
body's tissues to high levels of the hormone cortisol. I've talked to doctors
who implied that it was black and white, i.e. you have Cushing's or you don't.
My personal opinion, and I'm not a doctor, is that there is a linear gray area
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