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Welcome to the Quality Counts. For those health conscious consumers and medical professionals that are looking to purchase nutritional supplements, vitamins, herbs, learning about medications, losing weight, health food, low carbs, high protein nutrition, and exercise, you have come to the right place. Quality Counts serves both the medical practitioner and consumer interested in nutritional therapy and alternative medicine.

Health > Health Conditions > Impotence

Impotence

I get some many emails on this that I put together a short version.  See the side bar.

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  • Propionyl-L-carnitine, L-arginine and niacin in sexual medicine: a nutraceutical approach for erectile dysfunction - Andrologia. 2011 Oct 4 - "In a group of 54 unselected men (35-75 years), consecutively presenting to our ED clinic and naive to other ED treatments, we carried out a single-blind, one-arm study to evaluate the effects of a 3-month supplementation with propionyl-L-carnitine, L-arginine and niacin on their sexual performance ... Analyses on GAQs revealed that treatment improved erections in 40% of cases, with a partial response occurring in up to 77% of enrolled subjects. These preliminary findings indicate that the favourable cardiovascular effects of nutraceuticals might also reflect on male sexual function with possible implication in the treatment and prevention of ED. This study documents a considerable patients' interest toward nutritional supplementation - as first-line or adjunctive treatment to PDE5 inhibitors - that goes beyond the measurable increment in penile rigidity" - See Ester Carnitine Propionyl at iHerb, Twinlab niacin 1000mg at iHerb and Jarrow Formulas, Arginine 1000, 1000 mg, 100 Easy-Solv Tablets at iHerb.
  • Effect of α-lipoic acid on sperm quality, reproductive tract measures in thinner exposed rats - Andrologia. 2011 Sep 15 - "The aim of this study was to investigate the effect of alpha lipoic acid (ALA, an universal antioxidant) on thinner-induced testicular toxicity regarding spermatological features, body and reproductive tract measures in rats. Adult male Sprague-Dawley rats were divided into five treatment groups, eight rats in each. Control group was treated with placebo. Group O was given only olive oil. The group L received only α-lipoic acid. Thinner + Lipoic Acid group received thinner + α-lipoic acid and group T received only thinner. Thinner alone administration caused significant decreases in body and some reproductive organ weights, sperm count, motility and sperm membrane integrity, and significant increases in seminal vesicle weight and abnormal sperm rates compared with the values in the control group. However, concomitant administration of thinner with α-lipoic acid provided significant improvements in sperm parameters compared with values in alone group T.  In conclusion, the results of this study suggest that α-lipoic acid has a protective effect against thinner-induced reproductive dysfunction in male rats" - See Alpha lipoic acid products at iHerb.  I assume that the thinner is something like this:
  • Antioxidants of growing interest to address infertility, erectile dysfunction - Science Daily, 7/28/11 - "A growing body of evidence suggests that antioxidants may have significant value in addressing infertility issues in both women and men, including erectile dysfunction, and researchers say that large, specific clinical studies are merited to determine how much they could help ... Some commonly used antioxidants, such as vitamins C and E, could help, Hagen said. But others, such as lipoic acid, are a little more cutting-edge and set up a biological chain reaction that has a more sustained impact on vasomotor function and health ... Polyphenols, the phytochemicals that often give vegetables their intense color and are also found in chocolate and tea, are also of considerable interest"
  • Unhealthy lifestyle is associated with sexual dysfunction - Science Daily, 7/6/11 - "A new study published in The Journal of Sexual Medicine reveals that several unhealthy lifestyle factors, such as weight problems, physical inactivity, high alcohol consumption, tobacco smoking, and hard drugs are associated with sexual dysfunctions in men. Additionally, an unhealthy lifestyle is more common in persons who are sexually inactive ... Among those who had a sexual partner, risk of experiencing sexual dysfunction was greater in men who lead unhealthy lives by 71% in those with substantially increased waist circumference and more than 800% in men using hard drugs. Women who used hashish had almost 3 times increased risk of anorgasmia (difficulties or inability to reach climax during sexual activity with a partner) compared to non-users"
  • Clinical Assessment of a Supplement of Pycnogenol® and l-arginine in Japanese Patients with Mild to Moderate Erectile Dysfunction - Phytother Res. 2011 May 27 - "Subjects were instructed to take a supplement (Pycnogenol® 60 mg/day, l-arginine 690 mg/day and aspartic acid 552 mg/day) or an identical placebo for 8 weeks, and the results were assessed using the five-item erectile domain (IIEF-5) of the International Index of Erectile Function. Additionally, blood biochemistry, urinalysis and salivary testosterone were measured. Eight weeks of supplement intake improved the total score of the IIEF-5. In particular, a marked improvement was observed in 'hardness of erection' and 'satisfaction with sexual intercourse'. A decrease in blood pressure, aspartate transaminase and γ-glutamyl transpeptidase (γ-GTP), and a slight increase in salivary testosterone were observed in the supplement group. No adverse reactions were observed during the study period. In conclusion, Pycnogenol® in combination with l-arginine as a dietary supplement is effective and safe in Japanese patients with mild to moderate erectile dysfunction" - See Pycnogenol products at iHerb, l-arginine products at iHerb and l aspartic acid products at iHerb.
  • Erectile dysfunction association with physical activity level and physical fitness in men aged 40-75 years - Int J Impot Res. 2011 May 12 - "This study showed that younger men with higher physical activity and better physical fitness are less likely to suffer from erectile dysfunction. Multivariable analysis through logistic regression showed that age (odds ratio (OD)=1.15; 95% confidence interval (95% CI)=1.07-1.23), physical activity (OD=10.38; 95% CI=3.94-27.39) and physical fitness (OD=4.62; 95% CI=1.75-12.25) were independent variables associated with erectile dysfunction. This study reinforces the concept that healthy habits have a direct effect on erectile function"
  • Natural aphrodisiacs: 'Spicing' up your love life possible, finds study of ginseng and saffron - Science Daily, 3/28/11 - "Ours is the most thorough scientific review to date. Nothing has been done on this level of detail before now ... They found that panax ginseng, saffron and yohimbine, a natural chemical from yohimbe trees in West Africa, improved human sexual function ... People report increased sexual desire after eating muira puama"
  • Fenugreek extract shows male libido boost: Human RCT - Nutra USA, 2/16/11 - "A formulation containing a standardized extract of Trigonella foenum-graecum and minerals was associated with an improvement in libido for 81 percent of the men in the study, and a 63 percent improvement in the ‘quality of sexual performance’, compared with no such improvements in the placebo group"  - See Fenugeek products at iHerb.
  • Physiological Aspects of Male Libido Enhanced by Standardized Trigonella foenum-graecum Extract and Mineral Formulation - Phytother Res. 2011 Feb 10 - "The aim of the clinical study was to evaluate the effect of Testofen, a standardized Trigonella foenum-graecum (Fenugreek) extract and mineral formulation, on male libido (sexual drive, urge or desire) in a double blind randomized placebo controlled study. The study recruited 60 healthy males aged between 25 and 52, without erectile dysfunction and randomized to an oral dose (two tablets per day) of the active treatment (600 mg Testofen per day) or placebo for 6 weeks. The primary outcome measure was the DISF-SR (male) self-administered QOL total score and the four domain scores. The secondary outcome was specific quality of life parameters. Testofen had an overall positive effect on physiological aspects of libido. In particular, there was a significant increase in the subdomains of sexual arousal and orgasm. Testofen had a positive effect on QOL in self-reported satisfaction with muscle strength, energy and well-being but did not have an effect on mood or sleep. Serum prolactin and testosterone levels remained within the reference range. It was concluded that Testofen demonstrated a significant positive effect on physiological aspects of libido and may assist to maintain normal healthy testosterone levels" - See Fenugeek products at iHerb.
  • Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction - Urology. 2011 Jan;77(1):119-22 - "L-arginine supplementation improves nitric oxide-mediated vasodilation and endothelial function; however, oral administration has been hampered by extensive presystemic metabolism. In contrast, L-citrulline escapes presystemic metabolism and is converted to L-arginine, thus setting the rationale for oral L-citrulline supplementation as a donor for the L-arginine/nitric oxide pathway of penile erection ... A total of 24 patients, mean age 56.5 ± 9.8 years, were entered and concluded the study without adverse events. The improvement in the erection hardness score from 3 (mild ED) to 4 (normal erectile function) occurred in 2 (8.3%) of the 24 men when taking placebo and 12 (50%) of the 24 men when taking L-citrulline (P < .01). The mean number of intercourses per month increased from 1.37 ± 0.93 at baseline to 1.53 ± 1.00 at the end of the placebo phase (P = .57) and 2.3 ± 1.37 at the end of the treatment phase (P < .01). All patients reporting an erection hardness score improvement from 3 to 4 reported being very satisfied" - See L-citrulline products at iHerb.
  • Increasing BPA levels in urine associated with worsening male sexual function, study finds - Science Daily, 5/26/10 - "Increasing urine BPA level is associated with decreased sexual desire, more difficulty having an erection, lower ejaculation strength and lower level of overall satisfaction with sex life" - See stainless steel water bottles at Amazon.com.
  • Lack of omega-3 fatty acid linked to male infertility, study suggests - Science Daily, 4/12/10 - "In our experiment, we used 'knockout' mice that lacked the gene responsible for an enzyme important in making docosahexaenoic acid (DHA). In the absence of DHA, male mice are basically infertile, producing few if any misshaped sperm that can't get where they need to go ... But, when DHA was introduced into the diet, fertility was completely restored. "It was very striking. When we fed the mice DHA, all these abnormalities were prevented,"" - See Jarrow Max DHA at iHerb.
  • A new herbal combination, Etana, for enhancing erectile function: an efficacy and safety study in animals - Int J Impot Res. 2009 Jun 4 - "a new herbal combination called Etana that is composed of five herbal extracts including Panax quinquelotius (Ginseng), Eurycoma longifolia (Tongkat Ali), Epimedium grandiflorum (Horny goat weed), Centella asiatica (Gotu Kola) and flower pollen extracts. Most of the above-mentioned extracts have a long historical and traditional use for erectile dysfunction (ED) ... penile erection index (PEI) ... At a 7.5 mg kg(-1) single dose, the percentage of responding rats was 53+/-7 with a PEI of 337+/-72 compared with 17+/-6 with a PEI of 30+/-10 for control animals. This PEI was significantly (P<0.001) higher than each single component and than the sum of any two herbal components of Etana. When compared with sildenafil citrate, Etana induced more pronounced PEI than 0.36 mg kg(-1), but similar to 0.71 mg kg(-1) of sildenafil. Furthermore, full acute and sub-acute toxicity studies showed no toxic effects of Etana. In conclusion, this study describes a new and safe combination of herbal components that enhance erectile function in male rats"
  • Talking And Treating Erectile Dysfunction - Science Daily, 2/4/09 - "Stop smoking ... Control cholesterol ... Cut back on fat"
  • Ingredient in Chinese Herb Acts as a Natural Viagra - WebMD, 9/26/08 - "the main compound in horny goat weed, called icariin, acted the same way that Viagra does" - See horny goat weed products at iHerb.
  • Antioxidant treatment with alpha-tocopherol improves erectile function in hypertensive rats - Hypertens Res. 2008 May;31(5):1007-13 - "Treatment with 24 mg alpha-tocopherol decreased TBARS levels and increased SOD activity in the serum and corpus cavernosum. Relaxation in response to acetylcholine chloride in the corpus cavernosum was improved with alpha-tocopherol treatment at each dose. These results suggest that alpha-tocopherol treatment increases the diminished relaxation in the corpus cavernosum of SHRs by improving neuronal or endothelial function related to nitric oxide and carbon monoxide. This, in turn, indicates that antioxidant therapy may play a role in treatment for ED in hypertensive patients"
  • Berries and pomegranate - the ultimate Valentine's combo? - Nutra USA, 2/14/08 - "The results of this study demonstrated, for the first time, that daily consumption of PJ for seven weeks caused increased spermatogenic cell density, epididymal sperm concentration, sperm motility and decreased abnormal sperm rate related with decreased lipid peroxidation in male rats ... Forty-seven per cent of subjects reported erections improvements as a result of pomegranate juice, compared to only 32 per cent in the placebo group" - See pomegranate Juice Extracts at iHerb.
  • Exposure to the phytoestrogen daidzein attenuates apomorphine-induced penile erection concomitant with plasma testosterone level reduction in dose and time-related manner in adult rats - Urology. 2007 Sep;70(3):613-7 - "The phytoestrogen daidzein has the potential to adversely affect erectile function in a dose and time-related manner that is at least partly attributable to androgen deficiency. These findings implicate that phytoestrogens, especially isoflavones, if overconsumed for a long period, might be a novel risk factor for erectile dysfunction"
  • Erectile Dysfunction In Diabetes Is Due To Selective Defect In The Brain - Science Daily, 3/15/07
  • Erectile Function in Subjects With the Metabolic Syndrome - Medscape, 7/19/06 - "consumption of a Mediterranean-style diet in men with the metabolic syndrome and ED at baseline produced significant improvement of erectile and endothelial functions, together with a significant reduction of systemic vascular inflammation, as indicated by the reduced levels of CRP"
  • Restoring Sexual Potency? - Dr. Weil, 5/4/06 - "Arginine ... Ginkgo biloba ... Ashwaganda"
  • Sexual Enhancement Supplements (L-Arginine, Yohimbe, Horny Goat Weed) - ConsumerLab.com, 1/13/06
  • What about erectile dysfunction? - Dr. Murray Natural Facts, 8/24/05 - "by far the most common cause of impotence by far is atherosclerosis of the penile artery. Atherosclerosis refers to a process of hardening the artery walls due to a build up of plaque containing cholesterol, fatty material, and cellular debris"
  • Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes - Curr Med Res Opin. 2004 Sep;20(9):1377-84 - "Salvage therapy with PLC plus sildenafil was more effective than sildenafil in the treatment of ED in patients with diabetes refractory to sildenafil monotherapy" - See Ester Carnitine Propionyl at iHerb.
  • Erection Supplements Under Fire - WebMD, 9/23/04
  • Diet and Exercise Programs Have Benefits for Obese Men With Erectile Dysfunction - Doctor's Guide, 6/24/04
  • Daily 2-Mile Walk May Prevent Impotence - WebMD, 6/22/04
  • Carnitine Improves Symptoms of Male Aging - Medscape, 4/14/04 - "Carnitine is more active than testosterone for improving symptoms of male aging such as sexual dysfunction, depressed mood, and fatigue ... In this trial, 120 patients were randomized to receive testosterone undecanoate 160 mg/day, propionyl-L-carnitine 2 g/day plus acetyl-L-carnitine 2 g/day, or placebo for six months" [Abstract] - See iHerb or Vitacosticon acetyl-l-carnitine products and iHerb propionyl-l-carnitine.
  • Policosonal: Nature's Cholesterol Balancer - Vitamin Research News, 2/04 - "Statin drugs are also known to cause male impotence" - See iHerb or Vitacosticon policosanol products.
  • Regular Exercise Can Help Prevent Impotence - WebMD, 8/22/03 - "men over age 50 who kept physically active had a 30% lower risk of impotence than men who were inactive ... The fitter the man, the better the erection. Frequent, vigorous exercise, the equivalent of running at least three hours a week or playing singles tennis five hours per week, produced the most benefit -- with a 30% lower risk of impotence"
  • Korean Red Ginseng Benefits Men with Impotence - New Hope Natural Media, 1/2/03 - "Men experiencing sexual difficulties due to inability to achieve erection may be helped by Korean red ginseng (Panax ginseng), according to a study published in the Journal of Urology ... It is a problem that affects nearly half of men over age forty worldwide ... Some 60% of participants reported improved erections while receiving ginseng. Improved sexual desire was also reported during ginseng treatment. Testosterone levels did not change with treatment, leading the researchers to conclude that improvements observed with ginseng are not due to hormonal effects" - See iHerb or Vitacosticon Korean (Panax) ginseng.
  • Ginkgo Supplements Useful for SSRI-Related Sexual Dysfunction - Clinical Psychiatry News, 9/02 - "Ginkgo has multiple systemic effects. It acts as a free-radical scavenger, inhibits platelet aggregation, causes vasodilation, and allows more efficient cellular uptake of oxygen and glucose. The effects of ginkgo on sexual arousal are thought to result from increased blood circulation to the genital area ... The proprietary multi-ingredient ginkgo preparation ArginMax (Daily Wellness Co.) is “one of the best things I've ever seen for SSRI sexual dysfunction,”" - See ArginMax at drugstore.com
  • Natural Remedy for Erectile Dysfunction - New Hope Natural Media, 9/5/02 - "received three separate treatments for two weeks each, in random order: (1) 3.25 grams of arginine plus 6 mg of yohimbine, (2) yohimbine alone and (3) placebo ... Combination treatment was considered successful by 40% of the participants, compared with 28.9% with yohimbine alone and 17.8% with placebo ... Arginine is available in health food stores without a prescription, but yohimbine can be obtained only with a doctor's prescription. Although the herb yohimbe is sold in health food stores, it contains much less yohimbine than the amount used in the new study" - See iHerb and Vitacosticon arginine products.
  • Yohimbine Plus L-Arginine Potential Therapy For Mild To Moderate Erectile Dysfunction - Doctor's Guide, 7/31/02 - "randomly assigned 45 men with erectile dysfunction to treatment with 6 mg of L-arginine glutamate combined with 6 mg of yohimbine hydrochloride, to 6 mg of yohimbine hydrochloride alone, or to placebo ... They took the drugs orally one to two hours before intended sexual intercourse ... Changes in this score [Index of Erectile Function (IIEF)] were significantly greater among patients taking yohimbine plus L-arginine compared to those taking placebo" - Note: That "6 mg of L-arginine glutamate" has to be a misprint.  It probably should have been 6 grams as in a U. of Texas study on postmenopausal women.
  • Low testosterone levels can mean high health risks - Life Extension Magazine, 11/00
  • Study: Supplement Can Help Take the 'Dys' Out of Female Sexual Dysfunction, Researchers Promote Idea of 'Sexual Wellness' - WebMD, 6/5/01 - "ArginMax -- a dietary cocktail consisting of ginseng, ginkgo, B vitamins, calcium, folic acid, and other vitamins and minerals -- is being heralded as one component of a lifestyle that improves sexual performance and helps prevent problems associated with intimacy"
  • Want a love potion? What to know before you try - CNN, 6/15/00 - "a study of 21 men with "mild to moderate" impotence taking a supplement called ArginMax (3,000 milligrams per day) found big improvements in erection and sexual satisfaction."
  • When It Comes to Love, the Nose Knows - WebMD, 2/14/01- "Another spirit in the heady cocktail making us intoxicated with romantic love is phenylethylamine (PEA) ... I believe that PEA may be the hormone of libido ... high PEA levels help explain increased sex drive and activity in the manic phase of manic-depressive illness, while low PEA levels reflect loss of libido in depression. PEA is effective when given by mouth, but like Viagra, could be dangerous in patients with heart disease" -
    • Note: Amino Acids anyone? at DrBob.org says "L-phenylalanine can also be converted (through a separate pathway) to phenylethylamine, a substance that occurs naturally in the brain and appears to elevate mood."
  • Study: Oversexed Monkeys Immune - Intelihealth, 11/11/00 - "Promiscuous species of monkeys appear to have stronger immune systems than less-active ones, researchers say."
  • Herbal Viagra Alternative Works -- at Least on Rats - WebMD, 10/23/00 - "All the rats fed the high-cholesterol diet indeed ended up with high cholesterol levels -- and all became impotent. But those who drank the herbal mixture [BetterMAN] were later able to achieve erections, while the other eight rats remained impotent"
  • Study finds exercise reduces the risk of impotence - CNN, 10/2/00
  • Exercise May Reduce Impotence Risk - Intelihealth, 10/2/00
  • With Regular Exercise, You May Never Need Viagra - WebMD, 8/30/00
  • Laboratory Investigations of Erectile Dysfunction - WebMD - "men with erectile dysfunction frequently have low levels of high-density lipoproteins, the good form of cholesterol." - see HDL
  • Saving Yourself from AGE - Life Enhancement Magazine, 8/00 - with American Ginseng, "The researchers found a reduction in plasma prolactin, a hormone connected with passive "nesting" behavior, suggesting that this may play a role in the ability of American ginseng to stimulate sexual activity in the male rat."
  • Want a love potion? What to know before you try - CNN, 6/15/00 - "a study of 21 men with "mild to moderate" impotence taking a supplement called ArginMax (3,000 milligrams per day) found big improvements in erection and sexual satisfaction."
  • Natural Alternatives to Viagra with Ellen Kamhi - WebMD, 5/26/00
  • Replenish Testosterone Naturally - Life Extension Magazine, 1/00
  • Study finds new therapy for impotence [l-arginine] - CNN, 10/27/99
  • Be All That You Can Be - Life Enhancement Magazine, 7/99
  • Dehydroepiandrosterone in the treatment of erectile dysfunction: a prospective, double-blind, randomized, placebo-controlled study - Urology. 1999 Mar;53(3):590-4; discussion 594-5
  • Long Term Safety and Efficacy of Ginkgo Biloba in the Treatment of Anti-Depressant-Induced Sexual Dysfunction - Alan Jay Cohen, M.D., UCSF Faculty
  • Ginkgo biloba for antidepressant-induced sexual dysfunction - J Sex Marital Ther. 1998 Apr-Jun;24(2):139-43

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