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Home > Anti-aging Research > DHEA

DHEA

Specific Recommendations:

• DHEA products at iHerb
• 7-Keto products at iHerb
• DHEA products at Vitacost
• Drugstore.com/GNC DHEA products

Related Topics:

• Aromatization / I3C / DIM / Chrysin

7-Keto DHEA:

• 7-KETO - Vitacost Health Library
• Weight Loss—7-Keto DHEA - natmedonline.com
• 7-Keto DHEA The Fat-Burning Metabolite of DHEA - Life Extension Magazine, 5/05 - "By offering many of the advantages of DHEA supplementation without conversion to estrogen and testosterone, 7-Keto affords older adults the opportunity to further promote their health and longevity even when their levels of the so-called “downstream” hormones are already optimal. Moreover, considering 7-Keto’s demonstrated ability to improve body composition, it is highly likely that this DHEA metabolite will become a staple supplement for many aging adults"
• The Death of Anti-Aging Supplements? - Life Extension Magazine, 3/03 - "During these many trials, researchers routinely found that when taken daily, DHEA supplements effectively reduced depressive episodes and enhanced mood. In fact, according to one major study in the UK, as many as 67% of men and 82% of women reported a noticeable decrease in their depressive symptoms while taking as little as 25 mg/day of DHEA ... DHEA is recognized as one of the major adrenal androgens, and many of its abilities have been well-documented. We have learned through years of research that it enhances the immune system, fights osteoporosis, lowers hyperglycemia (high blood sugar) and may even help to mount a defense against HIV"
• Biotransformation of oral dehydroepiandrosterone in elderly men: significant increase in circulating estrogens - J Clin Endocrinol Metab 1999 Jun;84(6):2170-6 - "Serum testosterone and dihydrotestosterone remained unchanged after DHEA administration. In contrast, 17beta-estradiol and estrone significantly increased in a dose-dependent manner to concentrations still within the upper normal range for men [placebo vs. 50 mg DHEA vs. 100 mg DHEA; AUC 0-12 h for 17beta-estradiol, 510 +/- 198 vs. 635 +/- 156 vs. 700 +/- 209 pmol/L x h (P < 0.0001); AUC 0-12 h for estrone, 1443 +/- 269 vs. 2537 +/- 434 vs. 3254 +/- 671 pmol/L x h (P < 0.0001)]" - That's a 40% increase in the bad estrogen!!!  On top of that, if you are taking testosterone, that increases estrogen also.  See aromatization.

Other News:

• Dehydroepiandrosterone (DHEA) - Vitacost Health Library
• Dehydroepiandrosterone for Sports & Fitness - Vitacost Health Library
• Dehydroepiandrosterone for Weight Control - Vitacost Health Library
• DHEA Replacement Therapy - Life Extension Foundation
• DHEA - A Practical Guide - Ray Sahelian, M.D.
• DHEA (Dehydroepiandrosterone) - The Natural Pharmacist
• Depression Protocol - Life Extension Foundation
• Safer Estrogen with Phytonutrition - Michael A. Zeligs, M.D. - "The importance of supplementation with DIM is that this approach can decrease estrogen-related breast cancer risk in the majority of women. This includes women taking estrogen, DHEA, phytoestrogen supplements, or no hormonal replacement at all"
• DHEA? Hot on Hormones? - thenutritionreporter.com
• DHEAS Levels Linked to Cognitive Function in Women - Medscape, 3/13/07 - "There are data that suggest that DHEA and DHEAS may have neuroprotective effects and that the decline in the production of these steroids with healthy aging may contribute to neuronal dysfunction and degeneration, and thus cognitive decline ... women with higher circulating levels of DHEAS performed better on executive function tests. A positive association was also observed between circulating DHEAS and higher scores on tests of simple concentration and working memory in women with more than 12 years of education"
• DHEA Restores Oxidative Balance in Type 2 Diabetes - Medscape, 12/11/07 - "DHEA significantly reduced oxidative stress parameters in both plasma and peripheral blood mononuclear cells, the report indicates, and its administration was followed by a 50% decrease in levels of pentosidine (a marker of AGE formation)"
• Menopause tied to sexual dysfunction - MSNBC, 4/9/07 - "Women who have particularly low levels of the hormone DHEA during menopause may be more likely to have sexual dysfunction ... Women with relatively low blood levels of the hormone were 59 percent more likely to report sexual problems than those with high levels"
• Report: Why Dhea May Be The Best-Validated Anti-Aging Supplement - Life Extension Magazine, 11/06 - "The DHEA-treated subjects required significantly higher amounts of glucose to raise their blood sugar levels, demonstrating markedly improved insulin sensitivity ... DHEA is not for everyone—people with hormone-dependent cancers such as breast, uterine, and prostate cancers should avoid its use. However, an abundance of new studies suggests that ensuring optimal levels of this vital “prohormone” can help aging adults guard against endothelial dysfunction, vascular disease, metabolic syndrome, bone loss, and other debilitating conditions once thought to be the “inevitable” consequences of aging"
• Popular Anti-aging Supplement Has No Beneficial Effects, Mayo Clinic Study Finds - Science Daily, 10/19/06 - "For almost two years we restored DHEA in older men and women to the high normal levels that are usually observed in young people, but found no beneficial effects on age-related changes in body composition and function"
• Anabolic Hormone Deficiencies in HF - Medscape, 10/13/06 - "The finding suggests a potential for measurements of serum testosterone, dehydroepiandrosterone sulfate (DHEAS), and insulinlike growth factor-1 (IGF-1) to sharpen HF risk assessments ... The investigators showed "strong associations" between the hormone deficiencies and HF status"
• DHEA Supplements - ConsumerLab.com, 9/13/06
• DHEA May Be Effective for Depression Associated With HIV - Medscape, 1/24/06 - "DHEA is a weakly active adrenal androgen that serves as a precursor to testosterone and estradiol, which are hormones that can have a positive effect on mood when administered exogenously. In addition, the authors of the current study describe that DHEA increases the amount of available insulin-like growth factor, which in turn can increase levels of growth hormone. Growth hormone deficiency has also been linked with depressed mood. Finally, DHEA may modulate inflammatory cytokines, such as tumor necrosis factor, which may be related to depressed mood"
• Cortisol, Stress, and Health - Life Extension Magazine, 12/05 - "Supplements to reduce high cortisol levels secondary to stress ... Vitamin C: 1000-3000 mg/day ... Fish oil (omega-3 fatty acids):1-4 gm/day ... Phosphatidylserine: 300-800 mg/day ... Rhodiola rosea: 100-200 mg/day, standardized extract ... Ginseng: 100-300 mg/day, standardized extract ... Ginkgo biloba: 100-200 mg/day, standardized extract ... DHEA: 25-50 mg/day (any hormone supplementation should be monitored by your physician)"
• Does Replacing DHEA Improve Insulin Sensitivity? - Physician's Weekly, 5/16/05 - "DHEA replacement “significantly increased [sulfated ester of DHEA], bioavailable testosterone, and androstenedione and reduced sex hormone–binding globulin levels.” The DHEA group also had lower fasting plasma insulin and glucagon levels. “DHEA also [significantly] reduced total cholesterol, triglycerides, LDL cholesterol, and HDL cholesterol,”"
• How One Pill Escaped the List of Controlled Steroids - NY Times, 4/17/05
• Natural Female Hormone Replacement - Life Extension Magazine, 4/05
• DHEA May Be Effective for Midlife-Onset Minor and Major Depression - Medscape, 2/8/05
• DHEA May Help Midlife Depression - WebMD, 2/7/05 - "treatment with DHEA resulted in a 50% reduction in depression symptoms in half the participants ... Treatment with the supplement was associated with an increase in testosterone blood levels in both men and women ... Taking DHEA for 6 weeks also significantly improved sexual function scores"
• Abdominal Fat Decreases, Insulin Action Improves When Elderly Take Hormone - Science Daily, 11/17/04
• Hormone Protects Against Diseases of Aging - WebMD, 11/9/04 - "The elderly people in the study took 50 mg a day of DHEA ... Six months later, the DHEA group showed significant reductions in abdominal obesity (10% fat reduction around organs in the abdominal cavity among women and 7.4% among men) and improvements in insulin action or a decrease in insulin resistance"
• Increase in DHEA May Help Decrease Abdominal Fat in Elderly Persons - Doctor's Guide, 11/9/04 - "DHEA replacement therapy induced significant decreases in both visceral fat (within the abdomen) and subcutaneous abdominal fat (below the skin surface) in elderly men and women. "The decrease in visceral fat relative to initial values averaged 10.2 percent in the women and 7.4 percent in the men. The DHEA therapy also resulted in a significant decrease in abdominal subcutaneous fat, averaging approximately 6 percent in both the men and women"
• Stress-Busting Help Comes From Hormone - WebMD, 8/2/04 - "The people who reported fewer symptoms and who performed best at their military tasks had "significantly higher" levels of the hormone DHEA-S compared with cortisol" [Abstract]
• DHEA Sulphate Levels May Signify Low Libido - Doctor's Guide, 6/18/04
• DHEA Supplementation Linked to Improved Quality of Life in Women with Systemic Lupus Erythematosus - Doctor's Guide, 6/15/04 - "Their partners reported greater responses to the "gets more done" question compared to placebo ... DHEA replacement decreased high-density lipid (HDL) cholesterol, and it increased insulin-like growth factor (IGF-I) and haematocrit"
• DHEA Improves Quality of Life in Women With SLE - Medscape, 6/14/04
• Clinical Update on Benefits of DHEA - A4M, 4/6/04 - "Recently, researchers discovered important anti-inflammatory properties of DHEA. It was known that DHEA can lower the levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha)"
• DHEA Relieves Postmenopausal Symptoms - Healthwell Exchange Daily News, 3/18/04 - "DHEA supplementation can increase hormone levels in postmenopausal women toward premenopausal levels. They further suggest that women’s quality of life may be improved by DHEA supplementation after menopause. The increases in estrogen, testosterone, and DHEA levels observed in this study were 20 to 45% less than those observed in studies using 50 mg of DHEA per day, leading some to suggest that 25 mg per day might be a safer amount to use as a supplement"
• Supplement May Be Linked to Prostate Growth - WebMD, 3/10/04
• DHEA Linked To Early Signs Of Atherosclerosis - Intelihealth, 12/9/03
• Low-Dose DHEA Increases Androgen, Estrogen Levels in Menopause - Medscape, 12/12/03 - "Testosterone and dihydrotestosterone plasma levels, and plasma E1 and E2 levels increased significantly and progressively in both groups ... Cortisol F plasma levels progressively decreased throughout the study. Both groups also experienced significantly reduced LH and FSH plasma levels. GH and IGF-1 levels significantly increased in both groups. Supplementation did not induce changes in endometrial thickness ... These data support and confirm that DHEA must be considered a valid compound and drug for [hormone therapy] in postmenopausal women and not just a 'dietary supplement"
• FDA Grants Orphan Drug Designation For Fidelin (DHEA), Treatment For Adrenal Insufficiency - Doctor's Guide, 8/29/03
• DHEA May Fight Heart Disease, But How? - WebMD, 7/23/03 - "Endothelial dysfunction is known to contribute to atherosclerosis or hardening of the arteries ... men who received 25 mg per day of DHEA supplements for 12 weeks experienced significant improvement in endothelial function as well as insulin sensitivity compared with those who took a placebo" - See 7-Keto products at iHerb.
• Disappointing Data Confound Claims For DHEA Effectiveness [against Alzheimer's] - Psychiatric News, 6/6/03 - "Twenty-eight patients were blindly chosen to receive 50 mg of DHEA twice a day for six months ... The dose of DHEA, Wolkowtiz said, was targeted to achieve blood levels of the hormone at or slightly above the top of the normal range of DHEA levels found in healthy young adults ... numerically, DHEA did have a benefit on cognitive ratings, but overall, on the CIBIC-Plus, there was no significant benefit shown ... at three months, the DHEA group, compared with placebo, showed a trend toward improvement on the ADAS-Cog, but the improvement only narrowly missed being statistically significant ... DHEA has been reported to reduce cortisol, the so-called "stress hormone," which in response to stress is released in large quantities that have been linked to neuronal stress and damage" -  Does anyone detect bias in that title?  I don't know if DHEA helps Alzheimer's or not but I feel the title should have been something like "Alzheimer's Shows Trend Toward Improvement with DHEA at 3 Months".  Their attitude seems to be that nothing works except what we write prescriptions for.  The way I understand it, Alzheimer's usually gets worse, not better and cholinesterase inhibitors slow the disease, they don't reverse it and three months is a short time to determine if it is working.  See iHerb or Vitacost DHEA products. - Ben
• DHEA Beneficial for People with Schizophrenia - New Hope Natural Media, 4/24/03
• Some DHEA Supplements Are Better than Others - New Hope Natural Media, 3/6/03
• DHEA Augmentation Improves Schizophrenic Symptoms - Medscape, 2/13/03 - "In humans, DHEA has demonstrated efficacy in the improvement of mood, with increased energy, interest, confidence, and activity levels in various populations ... DHEA demonstrates potent neuroprotective qualities and plays an important role in neurodevelopment"
• Some DHEA Pills Don't Live Up to Label - WebMD, 12/11/02
• Dehydroepiandrosterone Reduces Flares in Mild-to-Moderate Systemic Lupus Erythematosus - Doctor's Guide, 12/6/02
• Testosterone Deficiency & Depression, Does DHEA Raise the Levels of Bioavailable Testosterone in Men? - Life Extension Magazine, 8/02 - "a well-controlled study published in the prestigious Journal of Clinical and Experimental Endocrinology and Metabolism did in fact find a significant rise in free testosterone in men aged 60 to 84 years, after three months on 100 mg of DHEA"
• The Benefits of Carnitine and DHEA for Fat Metabolism - Life Extension Magazine, 8/02 - "Carnitine is an amino acid that's critical for converting fatty acids into fuel. Because of this, it has the potential to help people lose weight ... A lack of DHEA may be one of the primary causes of insulin resistance"
• Cover Story: DHEA and Anti-aging Medicine - Life Extension Magazine, 6/02 - "The aging process is inextricably tied to a decrease in beneficial hormones, such as growth hormone, thyroid and DHEA, and an increase in hormones whose elevated levels are clearly harmful, such as insulin and cortisol"
• Low Dose DHEA Proves Effective in Treating Physical And Mental Conditions of Hypopituitarism - Doctor's Guide, 5/6/02 - "the women who took DHEA showed increased initiative, stamina, alertness and sexual relations. During the open treatment period, all of the women being treated with DHEA showed an increase in sexual interest and activity ... Women in the study also experienced several physical changes from the DHEA treatments. These changes included alterations in the skin's oiliness, moisture and elasticity (53 percent); increased perspiration during physical activity (63 percent); increases in axillary and/or pubic hair (76 percent); and increased handgrip strength"
• Mountain Life May Make Women Age Faster - WebMD, 4/24/02 - "New research shows that life at high altitudes can speed the aging process for a woman by affecting her hormones ... In fact, by age 70, the levels of DHEA in the women who lived in the mountains were only about 40% of those in the comparison group"
• I have been taking SAMe for depression and it has been working well. I just found out that my DHEA is low. I am 52 years old. Is it advisable to take SAMe and DHEA together? - Life Extension Foundation, 1/02
• Dehydroepiandrosterone Decline Reflects Immune System Activation - Doctor's Guide, 12/13/01
• Possible treatment for female sexual dysfunction - Life Extension Foundation, 9/01
• DHEA: Anti-Aging Hormone - Life Extension Foundation, 8/01 - "Low levels of DHEA are associated with aging and disease states. Specifically, a deficiency of DHEA has been found to correlate with immune dysfunction, inflammation, greater risk of certain cancers, heart disease in men, and osteoporosis"
• Health Supplement [DHEA] A Hit Among Lupus Sufferers - Intelihealth, 8/13/01
• Low-Dose DHEA Has Beneficial Effects In Women With Low Androgens - Doctor's Guide, 6/24/01
• Unisex Hormones?, Testosterone, DHEA May Help Both Sexes - WebMD, 5/4/01 - "Low levels of male hormones probably account for decreased muscularity, sexual interest, and bone density in menopausal women ... a 50 mg dose of DHEA each day enhanced sexual interest and satisfaction in aging women, while promoting stronger bones and younger-looking skin"
• DHEA: Dehydroepiandrosterone - Medscape, 11/00
• Studies Show DHEA Quells Lupus - Nutrition Science News, 10/00
• Could Drug Containing DHEA Be an Answer for Lupus? - WebMD, 6/23/00
• DHEA: A Mental & Physical Boost - Life Extension Magazine, 12/99
• A year-long French study finds that DHEA Can Help Keep. . . Women in Love - Life Enhancement Magazine, 6/00
• Depression and DHEA Treatment - Life Extension Magazine, 10/27/99
• Dehydroepiandrosterone Speeds Up Donor Site Healing In Skin Grafting - Doctor's Guide, 3/17/00
• DHEA: Is It Right For You? - about.com women's health
• The Marriage of DHEA and 5-HTP for New and Better Mood Function - Life Enhancement Magazine, 7/99
• DHEA, a better antidepressant - Life Enhancement Magazine, 7/99
• Dipping DHEA Levels May Trigger Lupus - Nutrition Science News, 1/99
• Juvenile Rheumatoid Arthritis Linked To Low Levels Of Certain Hormones - Doctor's Guide, 12/8/98 - "The UI data showed reduced levels of DHEA-S and testosterone in the synovial fluid and serum of JRA patients. In addition, the ratio of DHEA/DHEA-S in both synovial fluid and serum was much higher than that of the corresponding control serum, thus indicating the potential importance of hormonal imbalances in the JRA disease process"
• Caloric Restriction in Monkeys May Extend Life and Health - Doctor's Guide, 10/3/97 - "A second recent study from the NIA has shown caloric restriction slows the age-related decrease in amounts of a naturally-occurring steroid hormone, DHEA. Using natural DHEA levels as a biomarker of aging may assist scientists in their search for a way to slow down the aging process"
• DHEA - W. Dean & MD & Steven Fowkes

Abstracts:

• Serum DHEA-S Level Is Associated with the Presence of Atherosclerosis in Postmenopausal Women with Type 2 Diabetes Mellitus - Endocr J. 2008 May 21 - "intima-media thickness (IMT) ... Although simple regression analysis showed that log(DHEA-S) and IGF-I in men and log(DHEA-S) in women were significantly and inversely correlated with baPWV and IMT, only log(DHEA-S) in women was still significantly and inversely correlated with these atherosclerotic parameters after multiple regression analysis was adjusted for age, duration of diabetes, BMI, HbA(1C), systolic blood pressure, LDL-Cholesterol (C), serum creatinine, and smoking (Brinkman index). Serum DHEA-S level seemed to be associated with atherosclerosis in diabetic postmenopausal women independent of age, body stature, diabetic status, and other atherosclerotic risk factors, and might be a useful addition to other parameters for assessing the risk of atherosclerosis in this population" - See DHEA products at iHerb.
• Serum Dehydroepiandrosterone Sulfate Levels Predict Longevity in Men: 27-Year Follow-Up Study in a Community-Based Cohort (Tanushimaru Study) - J Am Geriatr Soc. 2008 Apr 18 - "in men after adjustments for age, systolic blood pressure, and fasting plasma glucose showed significantly (log-rank stat =10.6; P<.001) greater longevity in the highest group (200 mug/dL) than in the moderate (130-199 mug/dL) or lowest groups (129 mug/dL)"
• Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trial - Osteoporos Int. 2007 Dec 15 - "Among older healthy adults, daily administration of 50 mg of DHEA has a modest and selective beneficial effect on BMD and bone resorption in women, but provides no bone benefit for men"
• DHEA sulfate levels are associated with more favorable cognitive function in women - J Clin Endocrinol Metab. 2007 Dec 11 - "In the multiple linear regression analysis the DHEAS term made a significant independent positive contribution to the Controlled Oral Word Association Test score, a measure of executive function. In addition, women with a DHEAS level in the highest tertile who also had more than 12 years of education performed better on both Digit Span Forward and Digit Span Backward tests which are tests of simple concentration and working memory respectively"
• Dehydroepiandrosterone and monoamines in the limbic system of a genetic animal model of childhood depression - Eur Neuropsychopharmacol. 2007 Aug 20 - "The results from the current study may imply that treatment with DHEA could be a promising novel therapeutic option for depressed children and adolescents that fail to respond to common (monoaminergic) antidepressant treatments"
• Dehydroepiandrosterone administration counteracts oxidative imbalance and AGE formation in type 2 diabetic patients - Diabetes Care. 2007 Aug 17 - "Data indicate that DHEA treatment ameliorates the oxidative imbalance induced by hyperglycaemia, down-regulates the TNFalpha/TNFalpha receptors system and prevents AGE formation, suggesting a beneficial effect on the onset and/or progression of chronic complications in type 2 diabetic patients"
• Changes in Serum Sex Hormone Profiles after Short-term Low-dose Administration of Dehydroepiandrosterone (DHEA) to Young and Elderly Persons - Endocr J. 2007 Mar;54(1):153-62 - "In subjects who were older than 41 yrs. (older group) serum androstenedione and estradiol levels were elevated after the DHEA administration. Significant negative correlations were observed between the serum DHEA concentration and the serum concentration of fasting insulin, HOMA-R, leptin, and high-sensitivity C-reactive protein for all subjects. Daily administration of 25 mg DHEA increased the serum DHEA, DHEAS, androstenedione, and estradiol levels of the subjects of the older group to the same level as that of younger subjects"
• DHEA in elderly women and DHEA or testosterone in elderly men - N Engl J Med. 2006 Oct 19;355(16):1647-59
• Effects of DHEA Replacement Therapy on Bone Mineral Density in Older Adults: A Randomized, Controlled Trial - J Clin Endocrinol Metab. 2006 May 30 - "DHEA replacement therapy for 1 yr improved hip BMD in older adults and spine BMD in older women"
• Effects of dehydroepiandrosterone on gluconeogenic enzymes and glucose uptake in human hepatoma cell line, HepG2 - Endocr J. 2005 Dec;52(6):727-33 - "DHEA may act at multiple steps in the regulation of glucose metabolism in the liver"
• Relationship between serum sex steroids and Aging Male Symptoms score and International Index of Erectile Function - Urology. 2005 Sep;66(3):597-601 - "Although DHEA-S levels were significantly lower and E2 levels were greater in the men with aging male symptoms according to the AMS, the DHEA-S and FT levels were significantly lower in the men with sexual dysfunction, as determined by the IIEF score. Serum DHEA-S and FT levels and age correlated significantly with the IIEF scores"
• Serum dehydroepiandrosterone sulfate concentration and carotid atherosclerosis in men with type 2 diabetes - Atherosclerosis. 2005 Aug;181(2):339-44 - "evaluated intima-media thickness (IMT) and plaque score (PS) ... Negative correlations were found between DHEA-S concentration and IMT (r=-0.298, P<0.0001) and between DHEA-S concentration and PS (r=-0.308, P<0.0001). IMT and PS were significantly greater in patients with lower concentrations of DHEA-S (<1000ng/ml) than in patients with higher concentrations of DHEA-S"
• Effect of dehydroepiandrosterone replacement on insulin sensitivity and lipids in hypoadrenal women - Diabetes. 2005 Mar;54(3):765-9 - "replacement therapy with 50 mg of DHEA for 12 weeks significantly increased insulin sensitivity in hypoadrenal women, thereby suggesting that DHEA replacement could have a potential impact in preventing type 2 diabetes"
• Dehydroepiandrosterone Monotherapy in Midlife-Onset Major and Minor Depression - Arch Gen Psychiatry, 2/05 - "Six weeks of DHEA administration was associated with a significant improvement in the 17-Item Hamilton Depression Rating Scale and the Center for Epidemiologic Studies Depression Scale ratings"
• Effect of DHEA on Abdominal Fat and Insulin Action in Elderly Women and Men: A Randomized Controlled Trial - JAMA. 2004 Nov 10;292(18):2243-8 - "DHEA replacement could play a role in prevention and treatment of the metabolic syndrome associated with abdominal obesity"
• Dehydroepiandrosterone Relations to Dietary and Lifestyle Variables in a General Population Sample - Annals of Nutrition & Metabolism 2003;47:158-164 - "DHEA declines sharply with age and there is some evidence that the decline may be sharper in men than in women. Protein intake was significantly inversely associated with plasma levels of DHEA, whereas other dietary factors, energy expenditure and anthropometric variables were unrelated to this hormone"
• Dehydroepiandrosterone Augmentation in the Management of Negative, Depressive, and Anxiety Symptoms in Schizophrenia - Archives of General Psychiatry, 2/03 - "Results indicated significant improvement in negative symptoms (P<.001), as well as in depressive (P<.05) and anxiety (P<.001) symptoms in individuals receiving DHEA. This effect was especially noted in women"
• Double-blind treatment of major depression with dehydroepiandrosterone - Am J Psychiatry 1999 Apr;156(4):646-9 - "DHEA was associated with a significantly greater decrease in Hamilton depression scale ratings than was placebo. Five of the 11 patients treated with DHEA, compared with none of the 11 given placebo, showed a 50% decrease or greater in depressive symptoms"
• Biotransformation of oral dehydroepiandrosterone in elderly men: significant increase in circulating estrogens - J Clin Endocrinol Metab 1999 Jun;84(6):2170-6 - "Serum testosterone and dihydrotestosterone remained unchanged after DHEA administration. In contrast, 17beta-estradiol and estrone significantly increased in a dose-dependent manner to concentrations still within the upper normal range for men [placebo vs. 50 mg DHEA vs. 100 mg DHEA; AUC 0-12 h for 17beta-estradiol, 510 +/- 198 vs. 635 +/- 156 vs. 700 +/- 209 pmol/L x h (P < 0.0001); AUC 0-12 h for estrone, 1443 +/- 269 vs. 2537 +/- 434 vs. 3254 +/- 671 pmol/L x h (P < 0.0001)]" - That's a 40% increase in the bad estrogen!!!  On top of that, if you are taking testosterone, that increases estrogen also.  See aromatization.
• Dehydroepiandrosterone in the treatment of erectile dysfunction: a prospective, double-blind, randomized, placebo-controlled study - Urology. 1999 Mar;53(3):590-4 - "Our results suggest that oral DHEA treatment may be of benefit in the treatment of ED."
• Prevention of immune dysfunction and vitamin E loss by dehydroepiandrosterone and melatonin supplementation during murine retrovirus infection - Immunology. 1999 Feb;96(2):291-7
• DHEA protects against visceral obesity and muscle insulin resistance in rats fed a high-fat diet - Am J Physiol. 1997 Nov;273(5 Pt 2):R1704-8 - "These results show that DHEA has a protective effect against accumulation of visceral fat and development of muscle insulin resistance in rats fed a high-fat diet."
• Effect of 12-month DHEA replacement therapy on bone, vagina, and endometrium in postmenopausal women - J Clin Endocrinol Metab. 1997 Oct;82(10):3498-505 - "a finding of particular interest for both the prevention and treatment of osteoporosis."
• Dehydroepiandrosterone (DHEA) treatment of depression - Biol Psychiatry. 1997 Feb 1;41(3):311-8 - "These preliminary data suggest DHEA may have antidepressant and promemory effects"

Other DHEA retailers:

• iHerb
• Life Extension Products
• Vitacost.com
• Vitamin Shoppe
• DrugStore.com
• GNC @ drugstore.com
• GNC
• Netrition.com

Related Searches:

• Doctor's Guide search of DHEA
• Doctor's Guide (2) search of DHEA
• Intelihealth search of DHEA
• Life Extension Foundation search
• Medline search of DHEA
• Medscape search of DHEA
• Google search of DHEA
• MetaCrawler search of DHEA
• The Natural Pharmacist search of DHEA
• Nutrition Science News search
• WebMD search of DHEA

Recommended Books:

• Books on DHEA - Amazon.com

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