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Home > Anti-aging Research > DHEA

Dehydroepiandrosterone-sulphate (DHEA)

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7-Keto DHEA:

  • Pure Encapsulations - 7-Keto DHEA (100mg) - 60ct
  • 7-Keto DHEA The Fat-Burning Metabolite of DHEA - Life Extension Magazine, 5/05 - "By offering many of the advantages of DHEA supplementation without conversion to estrogen and testosterone, 7-Keto affords older adults the opportunity to further promote their health and longevity even when their levels of the so-called “downstream” hormones are already optimal. Moreover, considering 7-Keto’s demonstrated ability to improve body composition, it is highly likely that this DHEA metabolite will become a staple supplement for many aging adults"
  • The Death of Anti-Aging Supplements? - Life Extension Magazine, 3/03 - "During these many trials, researchers routinely found that when taken daily, DHEA supplements effectively reduced depressive episodes and enhanced mood. In fact, according to one major study in the UK, as many as 67% of men and 82% of women reported a noticeable decrease in their depressive symptoms while taking as little as 25 mg/day of DHEA ... DHEA is recognized as one of the major adrenal androgens, and many of its abilities have been well-documented. We have learned through years of research that it enhances the immune system, fights osteoporosis, lowers hyperglycemia (high blood sugar) and may even help to mount a defense against HIV"
  • Biotransformation of oral dehydroepiandrosterone in elderly men: significant increase in circulating estrogens - J Clin Endocrinol Metab 1999 Jun;84(6):2170-6 - "Serum testosterone and dihydrotestosterone remained unchanged after DHEA administration. In contrast, 17beta-estradiol and estrone significantly increased in a dose-dependent manner to concentrations still within the upper normal range for men [placebo vs. 50 mg DHEA vs. 100 mg DHEA; AUC 0-12 h for 17beta-estradiol, 510 +/- 198 vs. 635 +/- 156 vs. 700 +/- 209 pmol/L x h (P < 0.0001); AUC 0-12 h for estrone, 1443 +/- 269 vs. 2537 +/- 434 vs. 3254 +/- 671 pmol/L x h (P < 0.0001)]" - That's a 40% increase in the bad estrogen!!!  On top of that, if you are taking testosterone, that increases estrogen also.  See aromatization.

Other News:

  • Sex-specific effects of DHEA on bone mineral density and body composition - Science Daily, 12/4/18 - "Combining DHEA therapy with resistance exercise that imparts mechanical strain to bone may promote greater increases in muscle mass and BMD compared to either intervention alone," stated Jankowski. "The beneficial effects of DHEA replacement on body composition are to modestly increase fat-free mass in women and decrease fat mass in older men, a reversal of the usual age-related trends in muscle and fat." - See Pure Encapsulations 7-keto at Amazon.com.
  • DHEA Improves Sexual Function in Some Premenopausal Women - Medscape, 10/10/18 - "Androgen supplementation with dehydroepiandrosterone (DHEA) significantly improves sexual function in premenopausal, infertile women with poor sexual function ... assessed 50 premenopausal women who were older (average age, 41 years) and seeking treatment for infertility ... oral DHEA 75 mg once daily ... In the study cohort, mean FSFI score increased by 7%, with scores for desire, arousal, and lubrication increasing by 17%, 12%, and 8%, respectively. There were no changes in scores on the orgasm, satisfaction, or pain domains ... However, women whose FSFI scores were in the lowest quartile at baseline saw the greatest benefit, with an average increase of 34% ... And improvement was seen in all domains of sexual functioning for these women. Increases were 40% for desire, 46% for arousal, 33% for lubrication, 54% for orgasm, 24% for satisfaction, and 25% for pain" - See DHEA at Amazon.com.
  • Efficacy of Intravaginal Dehydroepiandrosterone (DHEA) on Moderate to Severe Dyspareunia and Vaginal Dryness, Symptoms of Vulvovaginal Atrophy, and of the Genitourinary Syndrome of Menopause - Medscape, 3/22/16 - "The daily intravaginal administration of 0.50% (6.5 mg) DHEA (Prasterone) has shown clinically and highly statistically significant effects on the four coprimary parameters suggested by the US Food and Drug Administration. The strictly local action of Prasterone is in line with the absence of significant drug-related adverse events, thus showing the high benefit-to-risk ratio of this treatment based upon the novel understanding of the physiology of sex steroids in women"
  • Intravaginal DHEA Eases Postmenopausal Vaginal Dryness, Pain - Medscape, 1/6/16 - "unlike lubricants and moisturizers, it actually corrects the problem ... Gynecologists saw 86% to 121% improvements in vaginal secretions, lining thickness, and tissue color in the women who used DHEA" - [Abstract]
  • Effect of DHEA-S on Metabolic Syndrome in Obese Women: Abstract and Introduction - Medscape, 10/12/12 - "Dehydroepiandrosterone-sulphate replacement produced weight loss in the obese women studied. Moreover, waist circumference, glucose and systolic and diastolic blood pressure, among other metabolic syndrome parameters, improved in the postmenopausal group, who showed a significant reduction in the total metabolic syndrome score (P < 0.05). In contrast, in premenopausal women, the effect of DHEA-S was limited to obesity parameters, and no effect was observed on metabolic syndrome components. No significant changes were evident in the placebo group"
  • Lower DHEA in Elderly Linked to Cardiovascular Events - Medscape, 6/27/12 - "Elderly men with decreased levels of dehydroepiandrosterone (DHEA) show increased rates of major cardiovascular events, even after adjustment for other traditional cardiovascular risk factors ... The men were all were participants in the Osteoporotic Fractures in Men Sweden study, a long-term project that is evaluating risk factors for various diseases ... Those in the lowest quartile of both DHEA and DHEA-S, compared with men in quartiles 2 through 4 of both, showed a higher risk for any major cardiovascular events (HR, 1.34; 95% CI, 1.06 - 1.70), coronary heart disease (HR, 1.41; 95% CI, 1.05 - 1.89), and cerebrovascular events (HR, 1.41; 95% CI, 1.00 - 1.99)"
  • Menopause pill may boost sex life - USATODAY.com, 12/20/11 - "This is the first evidence that low doses of DHEA (dehydroepiandrosterone), a hormone secreted by the adrenal glands, can help sexual function as well as menopausal symptoms ... women taking DHEA had a statistically significant increase in sexual interest and activity, with similar results for women in the HRT group. Sexual activity was also higher among the women taking tiboline, but the increase was not statistically significant"
  • Dehydroepiandrosterone Combined with Exercise Improves Muscle Strength and Physical Function in Frail Older Women - Medscape, 11/10/10 - "The current study found an improvement in strength and function with DHEA supplementation, but exercise, even at low intensity, may have been a requisite for this effect, as others have found in nonfrail subjects ... DHEA supplementation increased the concentration of all sex hormones studied, indicating a good therapeutic response. DHEAS levels increased five times, equal to those seen in a typical young adult[44] and similar to increases seen in other studies of older adults using 50-mg/d supplementation with DHEA.[10,12,17,18,20,32,45] Other studies have reported increases in estrogen and testosterone levels similar to those reported here.[10,17,18,45] The increases in estradiol and estrone levels reached those seen in premenopausal women, and the levels of testosterone were greater than in premenopausal women"
  • Dihydrotestosterone May Not Affect Prostate Growth But May Reduce BMD - Medscape, 11/16/10
  • Increasing fertility threefold with DHEA? - Science Daily, 7/1/10 - "women being treated for infertility who also received supplements of DHEA were three times more likely to conceive than women being treated without the additional drug ... The latter group took 75mg of the supplement daily for 40 days before starting fertility treatments, and continued for up to five months ... In the DHEA group, there was a 23% live birth rate as opposed to a 4% rate in the control group ... More than that, of the pregnancies in the DHEA group, all but one ended in healthy deliveries"
  • A Stronger Backbone: DHEA Hormone Replacement Increases Bone Density In Older Women - Science Daily, 5/17/09 - "Taking a DHEA supplement combined with vitamin D and calcium can significantly improve spinal bone density in older women ... The effects of the treatment differed for men and women. After the first year, women in the test group experienced an approximate 2 percent increase in bone density, while women in the control group did not see an increase. After the second year when both groups took the DHEA supplement, women in the test group experienced an additional 2 percent increase for a total of approximately 4 percent, while women who switched from placebo to DHEA also experienced an approximate 2 percent increase ... The same treatment, however, did not offer similar benefits for older men"
  • New Lab Evidence Suggests Preventive Effect Of Herbal Supplement In Prostate Cancer - Science Daily, 2/23/09 - "Combining DHEA with transforming growth factor beta-1 increased testosterone production in the stromal cells and prostate specific antigen protein secretion two to four-fold and gene expression up to 50-fold in the cancer cells. When these cell cultures were treated with red clover isoflavones, the androgenic effects of DHEA were reversed" - See Trinovin (for men), Promensil (for women) at Amazon.com.
  • DHEAS Levels Linked to Cognitive Function in Women - Medscape, 3/13/07 - "There are data that suggest that DHEA and DHEAS may have neuroprotective effects and that the decline in the production of these steroids with healthy aging may contribute to neuronal dysfunction and degeneration, and thus cognitive decline ... women with higher circulating levels of DHEAS performed better on executive function tests. A positive association was also observed between circulating DHEAS and higher scores on tests of simple concentration and working memory in women with more than 12 years of education"
  • DHEA Restores Oxidative Balance in Type 2 Diabetes - Medscape, 12/11/07 - "DHEA significantly reduced oxidative stress parameters in both plasma and peripheral blood mononuclear cells, the report indicates, and its administration was followed by a 50% decrease in levels of pentosidine (a marker of AGE formation)"
  • Menopause tied to sexual dysfunction - MSNBC, 4/9/07 - "Women who have particularly low levels of the hormone DHEA during menopause may be more likely to have sexual dysfunction ... Women with relatively low blood levels of the hormone were 59 percent more likely to report sexual problems than those with high levels"
  • Report: Why Dhea May Be The Best-Validated Anti-Aging Supplement - Life Extension Magazine, 11/06 - "The DHEA-treated subjects required significantly higher amounts of glucose to raise their blood sugar levels, demonstrating markedly improved insulin sensitivity ... DHEA is not for everyone—people with hormone-dependent cancers such as breast, uterine, and prostate cancers should avoid its use. However, an abundance of new studies suggests that ensuring optimal levels of this vital “prohormone” can help aging adults guard against endothelial dysfunction, vascular disease, metabolic syndrome, bone loss, and other debilitating conditions once thought to be the “inevitable” consequences of aging"
  • Popular Anti-aging Supplement Has No Beneficial Effects, Mayo Clinic Study Finds - Science Daily, 10/19/06 - "For almost two years we restored DHEA in older men and women to the high normal levels that are usually observed in young people, but found no beneficial effects on age-related changes in body composition and function"
  • Anabolic Hormone Deficiencies in HF - Medscape, 10/13/06 - "The finding suggests a potential for measurements of serum testosterone, dehydroepiandrosterone sulfate (DHEAS), and insulinlike growth factor-1 (IGF-1) to sharpen HF risk assessments ... The investigators showed "strong associations" between the hormone deficiencies and HF status"
  • DHEA Supplements - ConsumerLab.com, 9/13/06
  • DHEA May Be Effective for Depression Associated With HIV - Medscape, 1/24/06 - "DHEA is a weakly active adrenal androgen that serves as a precursor to testosterone and estradiol, which are hormones that can have a positive effect on mood when administered exogenously. In addition, the authors of the current study describe that DHEA increases the amount of available insulin-like growth factor, which in turn can increase levels of growth hormone. Growth hormone deficiency has also been linked with depressed mood. Finally, DHEA may modulate inflammatory cytokines, such as tumor necrosis factor, which may be related to depressed mood"
  • Cortisol, Stress, and Health - Life Extension Magazine, 12/05 - "Supplements to reduce high cortisol levels secondary to stress ... Vitamin C: 1000-3000 mg/day ... Fish oil (omega-3 fatty acids):1-4 gm/day ... Phosphatidylserine: 300-800 mg/day ... Rhodiola rosea: 100-200 mg/day, standardized extract ... Ginseng: 100-300 mg/day, standardized extract ... Ginkgo biloba: 100-200 mg/day, standardized extract ... DHEA: 25-50 mg/day (any hormone supplementation should be monitored by your physician)"
  • Does Replacing DHEA Improve Insulin Sensitivity? - Physician's Weekly, 5/16/05 - "DHEA replacement “significantly increased [sulfated ester of DHEA], bioavailable testosterone, and androstenedione and reduced sex hormone–binding globulin levels.” The DHEA group also had lower fasting plasma insulin and glucagon levels. “DHEA also [significantly] reduced total cholesterol, triglycerides, LDL cholesterol, and HDL cholesterol,”"
  • DHEA May Help Midlife Depression - WebMD, 2/7/05 - "treatment with DHEA resulted in a 50% reduction in depression symptoms in half the participants ... Treatment with the supplement was associated with an increase in testosterone blood levels in both men and women ... Taking DHEA for 6 weeks also significantly improved sexual function scores"
  • Abdominal Fat Decreases, Insulin Action Improves When Elderly Take Hormone - Science Daily, 11/17/04
  • Hormone Protects Against Diseases of Aging - WebMD, 11/9/04 - "The elderly people in the study took 50 mg a day of DHEA ... Six months later, the DHEA group showed significant reductions in abdominal obesity (10% fat reduction around organs in the abdominal cavity among women and 7.4% among men) and improvements in insulin action or a decrease in insulin resistance"
  • Increase in DHEA May Help Decrease Abdominal Fat in Elderly Persons - Doctor's Guide, 11/9/04 - "DHEA replacement therapy induced significant decreases in both visceral fat (within the abdomen) and subcutaneous abdominal fat (below the skin surface) in elderly men and women. "The decrease in visceral fat relative to initial values averaged 10.2 percent in the women and 7.4 percent in the men. The DHEA therapy also resulted in a significant decrease in abdominal subcutaneous fat, averaging approximately 6 percent in both the men and women"
  • Stress-Busting Help Comes From Hormone - WebMD, 8/2/04 - "The people who reported fewer symptoms and who performed best at their military tasks had "significantly higher" levels of the hormone DHEA-S compared with cortisol" [Abstract]
  • DHEA Sulphate Levels May Signify Low Libido - Doctor's Guide, 6/18/04
  • DHEA Supplementation Linked to Improved Quality of Life in Women with Systemic Lupus Erythematosus - Doctor's Guide, 6/15/04 - "Their partners reported greater responses to the "gets more done" question compared to placebo ... DHEA replacement decreased high-density lipid (HDL) cholesterol, and it increased insulin-like growth factor (IGF-I) and haematocrit"
  • DHEA Improves Quality of Life in Women With SLE - Medscape, 6/14/04
  • Clinical Update on Benefits of DHEA - A4M, 4/6/04 - "Recently, researchers discovered important anti-inflammatory properties of DHEA. It was known that DHEA can lower the levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha)"
  • DHEA Relieves Postmenopausal Symptoms - Healthwell Exchange Daily News, 3/18/04 - "DHEA supplementation can increase hormone levels in postmenopausal women toward premenopausal levels. They further suggest that women’s quality of life may be improved by DHEA supplementation after menopause. The increases in estrogen, testosterone, and DHEA levels observed in this study were 20 to 45% less than those observed in studies using 50 mg of DHEA per day, leading some to suggest that 25 mg per day might be a safer amount to use as a supplement"
  • Supplement May Be Linked to Prostate Growth - WebMD, 3/10/04
  • DHEA Linked To Early Signs Of Atherosclerosis - Intelihealth, 12/9/03
  • Low-Dose DHEA Increases Androgen, Estrogen Levels in Menopause - Medscape, 12/12/03 - "Testosterone and dihydrotestosterone plasma levels, and plasma E1 and E2 levels increased significantly and progressively in both groups ... Cortisol F plasma levels progressively decreased throughout the study. Both groups also experienced significantly reduced LH and FSH plasma levels. GH and IGF-1 levels significantly increased in both groups. Supplementation did not induce changes in endometrial thickness ... These data support and confirm that DHEA must be considered a valid compound and drug for [hormone therapy] in postmenopausal women and not just a 'dietary supplement"
  • FDA Grants Orphan Drug Designation For Fidelin (DHEA), Treatment For Adrenal Insufficiency - Doctor's Guide, 8/29/03
  • DHEA May Fight Heart Disease, But How? - WebMD, 7/23/03 - "Endothelial dysfunction is known to contribute to atherosclerosis or ... men who received 25 mg per day of DHEA supplements for 12 weeks experienced significant improvement in endothelial function as well as insulin sensitivity compared with those who took a placebo" - See DHEA at Amazon.com.
  • Disappointing Data Confound Claims For DHEA Effectiveness [against Alzheimer's] - Psychiatric News, 6/6/03 - "Twenty-eight patients were blindly chosen to receive 50 mg of DHEA twice a day for six months ... The dose of DHEA, Wolkowtiz said, was targeted to achieve blood levels of the hormone at or slightly above the top of the normal range of DHEA levels found in healthy young adults ... numerically, DHEA did have a benefit on cognitive ratings, but overall, on the CIBIC-Plus, there was no significant benefit shown ... at three months, the DHEA group, compared with placebo, showed a trend toward improvement on the ADAS-Cog, but the improvement only narrowly missed being statistically significant ... DHEA has been reported to reduce cortisol, the so-called "stress hormone," which in response to stress is released in large quantities that have been linked to neuronal stress and damage" -  Does anyone detect bias in that title?  I don't know if DHEA helps Alzheimer's or not but I feel the title should have been something like "Alzheimer's Shows Trend Toward Improvement with DHEA at 3 Months".  Their attitude seems to be that nothing works except what we write prescriptions for.  The way I understand it, Alzheimer's usually gets worse, not better and cholinesterase inhibitors slow the disease, they don't reverse it and three months is a short time to determine if it is working.  See DHEA at Amazon.com.
  • DHEA Beneficial for People with Schizophrenia - New Hope Natural Media, 4/24/03
  • Some DHEA Supplements Are Better than Others - New Hope Natural Media, 3/6/03
  • DHEA Augmentation Improves Schizophrenic Symptoms - Medscape, 2/13/03 - "In humans, DHEA has demonstrated efficacy in the improvement of mood, with increased energy, interest, confidence, and activity levels in various populations ... DHEA demonstrates potent neuroprotective qualities and plays an important role in neurodevelopment"
  • Some DHEA Pills Don't Live Up to Label - WebMD, 12/11/02
  • Dehydroepiandrosterone Reduces Flares in Mild-to-Moderate Systemic Lupus Erythematosus - Doctor's Guide, 12/6/02
  • Testosterone Deficiency & Depression, Does DHEA Raise the Levels of Bioavailable Testosterone in Men? - Life Extension Magazine, 8/02 - "a well-controlled study published in the prestigious Journal of Clinical and Experimental Endocrinology and Metabolism did in fact find a significant rise in free testosterone in men aged 60 to 84 years, after three months on 100 mg of DHEA"
  • The Benefits of Carnitine and DHEA for Fat Metabolism - Life Extension Magazine, 8/02 - "Carnitine is an amino acid that's critical for converting fatty acids into fuel. Because of this, it has the potential to help people lose weight ... A lack of DHEA may be one of the primary causes of insulin resistance"
  • Cover Story: DHEA and Anti-aging Medicine - Life Extension Magazine, 6/02 - "The aging process is inextricably tied to a decrease in beneficial hormones, such as growth hormone, thyroid and DHEA, and an increase in hormones whose elevated levels are clearly harmful, such as insulin and cortisol"
  • Low Dose DHEA Proves Effective in Treating Physical And Mental Conditions of Hypopituitarism - Doctor's Guide, 5/6/02 - "the women who took DHEA showed increased initiative, stamina, alertness and sexual relations. During the open treatment period, all of the women being treated with DHEA showed an increase in sexual interest and activity ... Women in the study also experienced several physical changes from the DHEA treatments. These changes included alterations in the skin's oiliness, moisture and elasticity (53 percent); increased perspiration during physical activity (63 percent); increases in axillary and/or pubic hair (76 percent); and increased handgrip strength"
  • Mountain Life May Make Women Age Faster - WebMD, 4/24/02 - "New research shows that life at high altitudes can speed the aging process for a woman by affecting her hormones ... In fact, by age 70, the levels of DHEA in the women who lived in the mountains were only about 40% of those in the comparison group"
  • I have been taking SAMe for depression and it has been working well. I just found out that my DHEA is low. I am 52 years old. Is it advisable to take SAMe and DHEA together? - Life Extension Foundation, 1/02
  • Dehydroepiandrosterone Decline Reflects Immune System Activation - Doctor's Guide, 12/13/01
  • Possible treatment for female sexual dysfunction - Life Extension Foundation, 9/01
  • DHEA: Anti-Aging Hormone - Life Extension Foundation, 8/01 - "Low levels of DHEA are associated with aging and disease states. Specifically, a deficiency of DHEA has been found to correlate with immune dysfunction, inflammation, greater risk of certain cancers, heart disease in men, and osteoporosis"
  • Health Supplement [DHEA] A Hit Among Lupus Sufferers - Intelihealth, 8/13/01
  • Low-Dose DHEA Has Beneficial Effects In Women With Low Androgens - Doctor's Guide, 6/24/01
  • Unisex Hormones?, Testosterone, DHEA May Help Both Sexes - WebMD, 5/4/01 - "Low levels of male hormones probably account for decreased muscularity, sexual interest, and bone density in menopausal women ... a 50 mg dose of DHEA each day enhanced sexual interest and satisfaction in aging women, while promoting stronger bones and younger-looking skin"
  • DHEA: Dehydroepiandrosterone - Medscape, 11/00
  • Studies Show DHEA Quells Lupus - Nutrition Science News, 10/00
  • Could Drug Containing DHEA Be an Answer for Lupus? - WebMD, 6/23/00
  • DHEA: A Mental & Physical Boost - Life Extension Magazine, 12/99
  • A year-long French study finds that DHEA Can Help Keep. . . Women in Love - Life Enhancement Magazine, 6/00
  • Depression and DHEA Treatment - Life Extension Magazine, 10/27/99
  • Dehydroepiandrosterone Speeds Up Donor Site Healing In Skin Grafting - Doctor's Guide, 3/17/00
  • DHEA: Is It Right For You? - about.com women's health
  • The Marriage of DHEA and 5-HTP for New and Better Mood Function - Life Enhancement Magazine, 7/99
  • DHEA, a better antidepressant - Life Enhancement Magazine, 7/99
  • Dipping DHEA Levels May Trigger Lupus - Nutrition Science News, 1/99
  • Juvenile Rheumatoid Arthritis Linked To Low Levels Of Certain Hormones - Doctor's Guide, 12/8/98 - "The UI data showed reduced levels of DHEA-S and testosterone in the synovial fluid and serum of JRA patients. In addition, the ratio of DHEA/DHEA-S in both synovial fluid and serum was much higher than that of the corresponding control serum, thus indicating the potential importance of hormonal imbalances in the JRA disease process"
  • Caloric Restriction in Monkeys May Extend Life and Health - Doctor's Guide, 10/3/97 - "A second recent study from the NIA has shown caloric restriction slows the age-related decrease in amounts of a naturally-occurring steroid hormone, DHEA. Using natural DHEA levels as a biomarker of aging may assist scientists in their search for a way to slow down the aging process"
  • DHEA - W. Dean & MD & Steven Fowkes

Abstracts: