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Depression

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Popular Medications:

• See anti-depressants

Popular Supplements:

• essential fatty acids / St. John's wort / acetyl-l-carnitine / DHEA / NADH / 5-HTP / omega-3 fatty acids / ginkgo / l-tyrosine / l-phenylalanine / TMG (SAM-e purcursor) / SAM-e / kava / melatonin / lavender / tianeptine

Alternative News:

• Depression Protocol - Life Extension Foundation
• Depression - The Natural Pharmacist
• I suffer from seasonal affective disorder. Do you have any suggestions? - Dr. Murray - "Melatonin supplementation may improve SAD because it not only increases brain melatonin levels, but also because it may suppress cortisol secretion"
• Sunshine for the Mind - thenutritionreporter.com
• Omega-3 Supplements Provide Mixed Results as Antidepressant - Medscape, 7/8/09 - "There is a large body of epidemiological data to support a link between omega-3 and depression ... For example, 8 of 11 epidemiological studies evaluating the association between depression and fish consumption report a statistically significant inverse association. In other words, less fish means more depression" - See Mega Twin EPA at iHerb and Jarrow Max DHA at iHerb.
• Can Omega-3 Fatty Acids Prevent Depression In Coronary Heart Disease? - Science Daily, 6/9/09 - "The prevalence of depression ranged from 23% in participants in the lowest tertile of omega –3 fatty acids (< 3.1% of total blood fatty acids) to 13% in participants in the highest tertile ( >4.3% of total blood fatty acids; p for trend = 0.004). Each unit decrease in EPA + DHA was inversely associated with depressive symptoms as a continuous variable, and these associations persisted after adjustment for age, sex and race. Similarly, each SD decrease in EPA + DHA was associated with significantly greater odds of depression as a dichotomous variable (Patient Health Questionnaire score >10)" - See Mega Twin EPA at iHerb and Jarrow Max DHA at iHerb.
• Kava for Anxiety: Is Short-Term Use Safe? - WebMD, 5/14/09 - "the WHO report suggested that liver toxicity may be limited to kava formulations that used the whole kava plant, instead of just the root, or used acetone and ethanol to extract the active ingredient from the plant instead of water ... As measured by standardized anxiety and depression questionnaires, the participants reported much less anxiety when they were taking the kava than when they took placebo pills ... Depression levels also dropped among many patients who reported depression and no serious side effects were associated with kava use" - See kava products at iHerb.
• Omega-3 Fatty Acids Ease Depressive Symptoms Related To Menopause - Science Daily, 1/28/09 - "Their study, published in the February issue of The American Journal of Clinical Nutrition, presents the first evidence that omega-3 supplements are effective for treating common menopause-related mental health problems ... Test results before and after the eight-week period indicate that omega-3s significantly improved the condition of women suffering symptoms of psychological distress and mild depression ... Women with hot flashes also noted that their condition improved after consuming omega-3s. At baseline, the number of daily hot flashes was 2.8 and dropped by an average of 1.6 in the group taking omega-3s and by 0.5 in the control group" - See Mega Twin EPA at iHerb and Jarrow Max DHA at iHerb.
• St. John's Wort for Depression - Clinical Psychology News, 12/08 - "The best available evidence suggests that St. John's wort is better than placebo for treating major depressive disorder, is as effective as some synthetic antidepressants when used in low to moderate dosing ranges, and has fewer side effects than do synthetic antidepressants"
• Symptoms Of Depression Associated With Increase In Abdominal Fat - Science Daily, 12/1/08 - "There are several mechanisms by which depression might increase abdominal fat, they note. Chronic stress and depression may activate certain brain areas and lead to increased levels of the hormone cortisol, which promotes the accumulation of visceral fat. Individuals with depression may have unhealthier lifestyles, including a poor diet, that could interact with other physiological factors to produce an increase in abdominal obesity" - See my cortisol page for ways to reduce it.  Cortisol is like the chicken and the egg with depression.  They don't seem to know whether it is the cause or result.
• St. John's Wort Holds Its Own in Meta-Analysis - Clinical Psychology News, 11/08 - "St. John's wort was more effective than placebo and just as effective as standard antidepressants in treating depression, a Cochrane analysis of 29 studies of almost 5,500 adults with major depression shows" - See Kira® (LI 160 extract) St. John's wort at iHerb.
• Magnetic Relief For Depression? - washingtonpost.com, 11/11/08
• St. John's Wort Relieves Symptoms Of Major Depression, Study Shows - Science Daily, 10/13/08 - "Cochrane Researchers reviewed 29 trials which together included 5,489 patients with symptoms of major depression. All trials employed the commonly used Hamilton Rating Scale for Depression to assess the severity of depression. In trials comparing St. John's wort to other remedies, not only were the plant extracts considered to be equally effective, but fewer patients dropped out of trials due to adverse effects" - See Kira® (LI 160 extract) St. John's wort at iHerb and Perika (WS 5570 extract) at iHerb.
• St. John’s Wort for Major Depression? - WebMD, 10/10/08 - "Can taking an herbal supplement be as good as a prescription medication for people who are severely depressed? ... Researchers in Germany think so" - See Kira® (LI 160 extract) St. John's wort at iHerb and Perika (WS 5570 extract) at iHerb.
• Taking herb 'helps depression'  - BBC News, 10/8/08 - "Overall, the St John's Wort extracts tested in the trials were superior to placebo, similarly effective as standard anti-depressants, and had fewer side effects ... Doctors think it works because the herb keeps serotonin, a chemical which makes you happy, in the brain for longer" - See Kira® (LI 160 extract) St. John's wort at iHerb and Perika (WS 5570 extract) at iHerb.
• Add-On Therapy Improves Depressive Symptoms In Bipolar Disorder - Science Daily, 9/2/08 - "sought to evaluate whether N-acetyl cysteine (NAC), an over-the-counter supplement that increases brain glutathione, might help alleviate depressive symptoms ... Glutathione is the brain’s primary antioxidant defense, and there is evidence of increased oxidative stress in bipolar disorder. Therefore, we studied the potential benefit of NAC treatment in bipolar disorder and found that it impressively remedied residual depressive symptoms" - See NAC products at iHerb.
• St. John's Wort and Duloxetine Equally Effective in Mild to Moderate Depression - Doctor's Guide, 9/1/08 - "Twenty patients received St. John's Wort at a dosage of 900 mg QD, whereas the remaining 20 participants were treated with duloxetine 60  30 mg QD ... In the group of patients suffering from moderate depression, we did not find any statistically significant differences between the 2 treatment groups" - See St. John's wort products at iHerb.
• Continuation and long-term maintenance treatment with Hypericum extract WS((R)) 5570 after recovery from an acute episode of moderate depression - A double-blind, randomized, placebo controlled long-term trial - Eur Neuropsychopharmacol. 2008 Aug 9 - "3x300 mg/day WS((R)) 5570 or placebo for 26 weeks. 426 patients were evaluated for efficacy. Relapse rates during continuation treatment were 51/282 (18.1%) for WS((R)) 5570 and 37/144 (25.7%) for placebo. Average time to relapse was 177+/-2.8 and 163+/-4.4 days for WS((R)) 5570 and placebo, respectively (time-to-event analysis; p=0.034; alpha=0.025 one-sided). Patients treated with WS((R)) 5570 showed more favorable HAMD and Beck Depression Inventory time courses and greater over-all improvement (CGI) than those randomized to placebo. In long-term maintenance treatment a pronounced prophylactic effect of WS((R)) 5570 was observed in patients with an early onset of depression as well as in those with a high degree of chronicity. Adverse event rates under WS((R)) 5570 were comparable to placebo. WS((R)) 5570 showed a beneficial effect in preventing relapse after recovery from acute depression. Tolerability in continuation and long-term maintenance treatment was on the placebo level" - Note:  The 5570 extract is the Perika Brand.  See Perika (WS 5570 extract) at iHerb.
• A double-blind dose-finding pilot study of docosahexaenoic acid (DHA) for major depressive disorder - Eur Neuropsychopharmacol. 2008 Jun 5 - "Group A (n=14): 1 g/day of oral DHA; Group B (n=11): 2 g/day; and Group C (n=10): 4 g/day. We measured HAM-D-17 scores, plasma DHA, eicosapentaenoic acid (EPA), and n-6/n-3 ratio. Completer response rates (>/=50% decrease in HAM-D-17 score) were 83% for Group A, 40% for Group B, and 0% for Group C; Groups A and B had significant decreases in HAM-D-17 scores" - See Jarrow Max DHA at iHerb.
• Rhodiola for What Ails You? - Dr. Weil, 5/15/08 - "A 2002 review in Herbalgram, the Journal of the American Botanical Council, reported that over the years, numerous studies of rhodiola in humans and animals have shown that it helps prevent fatigue, stress and the damaging effects of oxygen deprivation. Evidence also suggests that it has an antioxidant effect, enhances immune system function and can increase sexual energy ... A study published in 2007 in the Nordic Journal of Psychiatry showed that patients with mild-to-moderate depression who took a rhodiola extract reported fewer symptoms than those who took a placebo. And a study by researchers at the University of California at Irvine found that fruit flies that ate a diet supplemented with rhodiola lived an average of 10 percent longer than flies that didn't eat this herb" - See Rhodiola rosea products at iHerb.
• Plasma eicosapentaenoic acid is inversely associated with severity of depressive symptomatology in the elderly: data from the Bordeaux sample of the Three-City Study - Am J Clin Nutr. 2008 May;87(5):1156-62 - "Higher plasma EPA was associated with a lower severity of DS in elderly subjects, especially those taking antidepressants" - See Mega Twin EPA at iHerb.
• Many Depressed Older Adults Lack Vitamin D - WebMD, 5/6/08 - "Researchers reporting in the May issue of Archives of General Psychiatry have linked low blood levels of vitamin D -- the "sunshine vitamin" -- and increased parathyroid hormone levels to depression among older adults" - See vitamin D products at iHerb.
• Diets With High Omega-6:Omega-3 Ratios Enhance Risk for Depression, Inflammatory Disease - Medscape, 4/25/08 - "Whereas the early hunter-gatherers had a dietary omega-6:omega-3 ratio of 2:1 to 3:1, this ratio is now 15:1 to 17:1 in North America today ... It is believed that these dietary changes might be related to increases in inflammatory-related diseases, including depression and cardiovascular disease ... at higher levels of depressive symptoms, as the omega-6:omega-3 ratio increased, there was a marked increase in proinflammatory cytokine levels ... compared with the study participants who did not have syndromal depression, the 6 participants who had depression had significantly higher omega-6:omega-3 ratios and higher levels of proinflammatory cytokines" - See Mega Twin EPA at iHerb.
• Omega-3 EPA may benefit depressives, says study - Nutra USA, 4/7/08 - [Abstract] - "were randomly assigned to receive a daily EPA supplement (1000 mg, supplied by Minami Nutrition, Belgium), or 20 mg fluoxetine daily, or a combination of the two for two months ... At the end of the study, data from the 48 people who finished the study showed a 50 per cent reduction in HDRS scores for people in the EPA group, a 56 per cent reduction in people in the fluoxetin group, and a 81 per cent reduction in people in the combined intervention group" - See Mega Twin EPA at iHerb.
• Omega-3 Fatty Acids for Major Depressive Disorder During Pregnancy: Results From a Randomized, Double-Blind, Placebo-Controlled Trial - J Clin Psychiatry. 2008 Mar 18;:e1-e8 - "As compared to the placebo group, subjects in the omega-3 group had significantly lower HAM-D scores at weeks 6 (p = .001) and 8 (p = .019), a significantly higher response rate (62% vs. 27%, p = .03), and a higher remission rate, although the latter did not reach statistical significance (38% vs. 18%" - See Mega Twin EPA at iHerb and Jarrow Max DHA at iHerb.
• Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic acid and fluoxetine, separately and in combination, in major depressive disorder - Aust N Z J Psychiatry. 2008 Mar;42(3):192-8 - "EPA + fluoxetine combination was significantly better than fluoxetine or EPA alone from the fourth week of treatment. Fluoxetine and EPA appear to be equally effective in controlling depressive symptoms. Response rates (>/=50% decrease in baseline HDRS) were 50%, 56% and 81% in the fluoxetine, EPA and combination groups, respectively" - See Mega Twin EPA at iHerb.
• Association of folate intake with the occurrence of depressive episodes in middle-aged French men and women - Br J Nutr. 2007 Dec 6;:1-5 - "the risk of experiencing recurrent depressive episodes (two or more) during the follow-up was strongly reduced in men with high folate intake (OR 0.25 (95 % CI 0.06, 0.98) for the highest tertile v. the lowest" - See iHerb folic acid products.
• Folate may reduce depression symptoms for men, says study - Nutra USA, 12/7/07 - "male subjects with the highest average intake (235 micrograms per 100 kcal) were 50 per cent less likely to have depressive symptoms than men with the lowest average intake (119 micrograms per 100 kcal)" - [Abstract] - See iHerb folic acid products.
• High {omega}-6 and Low {omega}-3 Fatty Acids are Associated With Depressive Symptoms and Neuroticism - Psychosom Med. 2007 Nov 8 - "Lower EPA, and higher AA, AA:EPA ratio and AA:DHA ratio were associated with greater NEO-PI-R Neuroticism" - See Mega Twin EPA at iHerb.
• Low Omega-3s in Diet Linked to Higher Anxiety and Depressive Symptoms in Heart Failure Patients - Doctor's Guide, 11/7/07 - "Heart Failure patients who were prone to depressive symptoms ate 15% fewer omega-3 fatty acids and those with anxiety consumed 14% fewer omega-3 fatty acids than heart failure patients without symptoms"
• Augmenting antidepressants with folate: a clinical perspective - J Clin Psychiatry. 2007;68 Suppl 10:4-7 - "Folate in particular has been found to further reduce symptoms in patients with depression when used in conjunction with an antidepressant, and because folate is a water-soluble B vitamin, its safety and tolerability are well established. This strategy would typically be used in patients with low plasma or red blood cell folate levels. Folate augmentation may be used (1) to enhance the efficacy of antidepressants in nonresponders, (2) to enable those who partially respond to antidepressant monotherapy to achieve remission, and (3) to alleviate residual symptoms during antidepressant treatment" - See iHerb folic acid products.
• The role of folate in depression and dementia - J Clin Psychiatry. 2007;68 Suppl 10:28-33 - "folate deficiencies may be caused by improper absorption and utilization, often due to genetic polymorphisms. Individuals, therefore, can have insufficient levels or lack needed forms of folate, despite adequate intake. Supplementation with the active form of folate, methyltetrahydrofolate, which is more readily absorbed, may be effective in the prevention and treatment of both depression and dementia" - iHerb folic acid products.
• Antidepressant-Like Effect of Cordyceps sinensis in the Mouse Tail Suspension Test - Biol Pharm Bull. 2007 Sep;30(9):1758-62 - "Cordyceps sinensis (CS) has been known as a component of traditional medicines that elicit various biological effects such as anti-fatigue, immunomodulatory, and hypoglycemic actions. Since it has been well-established that fatigue is closely related to depression, we used the tail suspension test (TST) in mice to examine the antidepressant-like effects of hot water extract (HWCS) and supercritical fluid extract (SCCS) of CS ... these results suggest that SCCS may elicit an antidepressant-like effect by affecting the adrenergic and dopaminergic systems, but not by affecting the serotonergic system" - See Cordyceps products at iHerb.
• Dehydroepiandrosterone and monoamines in the limbic system of a genetic animal model of childhood depression - Eur Neuropsychopharmacol. 2007 Aug 20 - "The results from the current study may imply that treatment with DHEA could be a promising novel therapeutic option for depressed children and adolescents that fail to respond to common (monoaminergic) antidepressant treatments"
• Diets With High Omega-6:Omega-3 Ratios Enhance Risk for Depression, Inflammatory Disease - Medscape, 4/26/07 - "Whereas the early hunter-gatherers had a dietary omega-6:omega-3 ratio of 2:1 to 3:1, this ratio is now 15:1 to 17:1 in North America today ... compared with the study participants who did not have syndromal depression, the 6 participants who had depression had significantly higher omega-6:omega-3 ratios and higher levels of proinflammatory cytokines"
• Depressive Symptoms, omega-6:omega-3 Fatty Acids, and Inflammation in Older Adults - Psychosom Med. 2007 Mar 30 - "Diets with high n-6:n-3 PUFA ratios may enhance the risk for both depression and inflammatory diseases"
• Omega 3 fatty acids and the brain: review of studies in depression - Asia Pac J Clin Nutr. 2007;16 Suppl:391-7 - "Experimental studies in animals have shown that diets lacking omega 3 PUFA lead to substantial disturbances in neural function, which in most circumstances can be restored by the inclusion of omega 3 PUFA in the diet ... It is clear from the literature that DHA is involved in a variety of processes in neural cells and that its role is far more complex than simply influencing cell membrane properties"
• l-thyroxine augmentation of serotonergic antidepressants in female patients with refractory depression - J Affect Disord. 2007 Feb 6 - "Triiodothyronine (T3) augmentation in treatment-resistant depression had been successfully performed with both tricyclic as well as with SSRI antidepressants. In this paper, the efficacy of addition of moderate dose of l-thyroxine (T4) to serotonergic antidepressants in refractory depression was evaluated ... four weeks of l-thyroxine augmentation, the remission, assessed as 7 or less points on Hamilton Depression Rating Scale (HDRS) was obtained in eleven patients (64.7%). Five other patients (29.5%) had responded (reduction>50% on HDRS) and one patient did not show an improvement"
• Omega-3 in fish oils might ease depression - USA Today, 3/6/07 - "The more DHA a person consumed, the more gray matter there was in three areas of the brain linked to mood: the amygdala, the hippocampus and the cingulate, Conklin says. Seriously depressed people tend to have less gray matter in these areas" - See Jarrow Max DHA at iHerb.
• Vascular Nutritional Correlates of Late-Life Depression - Am J Geriatr Psychiatry. 2006 Sep;14(9):787-795 - "The depression group had higher intake of saturated fat and cholesterol, higher body mass indices, lower alcohol intake, and higher Keys score than the comparison group"
• Omega-3s may help depressive kids - pilot study - Nutra USA, 6/23/06 - "seven out of ten children in the omega-3 group and none of the children in the placebo group had depression score reductions of 50 per cent or more"
• Omega-3 treatment of childhood depression: a controlled, double-blind pilot study - Am J Psychiatry. 2006 Jun;163(6):1098-100 - "Analysis of variance showed highly significant effects of omega-3 on symptoms using the CDRS, CDI, and CGI ... Omega-3 fatty acids may have therapeutic benefits in childhood depression"
• Melatonin Improves Mood In Winter Depression - Science Daily, 5/2/06 - "melatonin, a naturally occurring brain substance, can relieve the doldrums of winter depression, also known as seasonal affective disorder, or SAD"
• Rapid recovery from major depression using magnesium treatment - Med Hypotheses. 2006 Mar 14 - "Case histories are presented showing rapid recovery (less than 7 days) from major depression using 125-300mg of magnesium (as glycinate and taurinate) with each meal and at bedtime. Magnesium was found usually effective for treatment of depression in general use" - See iHerb or Vitacost magnesium products.
• Depression and long chain n-3 fatty acids in adipose tissue in adults from Crete - Eur J Clin Nutr. 2006 Feb 8 - "The inverse relationship between adipose DHA and depression in adults, replicates findings of a previous study. This relationship indicates that a low long-term dietary intake of DHA is associated with an increased risk for depression in adults" - See Jarrow Max DHA at iHerb.
• Vitamin B(12) and folate serum levels in newly admitted psychiatric patients - Clin Nutr. 2005 Oct 7 - "About 30% of patients had low folate values compared to 2.5% in the control group" - See iHerb or Vitacost folic acid products.
• Chromium Picolinate Linked With Reduced Carbohydrate Cravings in People With Atypical Depression - Doctor's Guide, 9/29/05 - "65% of the chromium picolinate patients with high carbohydrate craving versus 33% of those receiving placebo had significantly greater improvements on total HAM-D-29 scores (p < 0.05). HAM-D-29 is a standard tool commonly used in assessing severity of symptoms in depressed patients" - See iHerb or Vitacost chromium products.
• Using Magnets to Treat Depression - ABC News, 5/17/05
• Omega-3 Fatty Acids and Depression - Clinical Psychiatry News, 5/05 - "English investigators conducted a 12-week, double-blind, placebo-controlled trial evaluating the efficacy of EPA doses of 1,000, 2,000, or 4,000 mg/day in addition to unchanged standard treatment in 70 patients with persistent depression. The 1,000-mg group showed a significant decrease in depression as compared with placebo, but the other groups showed little evidence of efficacy ... The bulk of evidence suggests that omega-3 fatty acid supplementation is effective in treating depression in patients with low omega-3 diets" - See Mega Twin EPA at Vitacost or iHerb.
• 'Mangia, Mangia!' -- Certain Foods Fight Depression - Science Daily, 3/25/05 - "confirmed the antidepressant-like effects of omega-3 fatty acids ... uridine, a compound found in sugar beets and molasses, has similar effects"
• DHEA May Be Effective for Midlife-Onset Minor and Major Depression - Medscape, 2/14/05
• DHEA May Help Midlife Depression - WebMD, 2/7/05 - "treatment with DHEA resulted in a 50% reduction in depression symptoms in half the participants ... Treatment with the supplement was associated with an increase in testosterone blood levels in both men and women ... Taking DHEA for 6 weeks also significantly improved sexual function scores" - See iHerbor Vitacost DHEA products.
• Major depressive disorder: probiotics may be an adjuvant therapy - Med Hypotheses. 2005;64(3):533-8 - "Stress, a significant factor in MDD [major depressive disorder], is known to alter GI microflora, lowering levels of lactobacilli and bifidobacterium. Research suggests that bacteria in the GI tract can communicate with the central nervous system, even in the absence of an immune response. Probiotics have the potential to lower systemic inflammatory cytokines, decrease oxidative stress, improve nutritional status, and correct SIBO. The effect of probiotics on systemic inflammatory cytokines and oxidative stress may ultimately lead to increased brain derived neurotrophic factor (BDNF). It is our contention that probiotics may be an adjuvant to standard care in MDD"
• Exercise for Depression Rivals Drugs, Therapy - WebMD, 1/26/05
• Exercising Has Great Mental Health Benefits - CBS 2 Chicago, 1/25/05 - "This is the first study that looks at exercise alone for treating mild to moderate depression. It found most symptoms were reduced almost in half by people who did some type of aerobic activity for at least 30 minutes, three to five times a week"
• Dietary Supplement Ups Antidepressant Effect - WebMD, 12/2/04 - "Half the patients in the study reported significant improvement in symptoms when they took SAMe along with their prescription antidepressant for six weeks. Forty-three percent reported having no depression symptoms at all six weeks after adding the dietary supplement to their treatment" - See iHerb or Vitacost SAMe products.
• Omega-3 Fatty Acids: Good For The Heart, And (maybe) Good For The Brain - Science Daily, 11/8/04 - "There is mounting evidence that a diet containing omega-3 fatty acids, already known to help prevent cardiovascular disease, may also prevent depression"
• Vitamin B6 level is associated with symptoms of depression - Psychother Psychosom. 2004 Nov-Dec;73(6):340-3 - "A low plasma level of PLP was significantly associated with the depression score"
• Serum Folate, Vitamin B(12), and Homocysteine in Major Depressive Disorder, Part 1: Predictors of Clinical Response in Fluoxetine-Resistant Depression - J Clin Psychiatry. 2004 Aug;65(8):1090-1095 - "The response rates for patients with (N = 14) and without (N = 38) low folate levels were 7.1% versus 44.7%, respectively" - See iHerb or Vitacost folic acid products.
• Serum Folate, Vitamin B(12), and Homocysteine in Major Depressive Disorder, Part 2: Predictors of Relapse During the Continuation Phase of Pharmacotherapy - J Clin Psychiatry. 2004 Aug;65(8):1096-1098 - "The relapse rates for patients with (N = 7) and without (N = 64) low folate levels were 42.9% versus 3.2%, respectively" - See iHerb or Vitacost folic acid products.
• Folate for depressive disorders - J Psychopharmacol. 2004 Jun;18(2):251-6 - "adding folate reduced Hamilton Depression Rating Scale (HDRS) scores on average by a further 2.65 points ... The remaining study found no statistically significant difference when folate alone was compared with trazodone"  - See iHerb or Vitacost folic acid products.
• Shock Treatment for Mild Depression? - Dr. Weil, 7/9/04
• Chromium Picolinate Supplementation Linked With Reduced Carbohydrate Cravings Associated With Atypical Depression - Doctor's Guide, 6/2/04 - [Nutra USA][WebMD]  "daily supplementation with 600 mcg of chromium as chromium picolinate, significantly reduced carbohydrate cravings compared to placebo, and improved other symptoms such as mood swings, fatigue and weight gain perception" - See iHerb or Vitacost chromium products.
• S-Adenosylmethionine (SAMe) - A Very Important Natural Product - Dr. Murray's Natural Facts, 6/2/04 - "SAMe is perhaps the most effective natural antidepressant (although a strong argument could be made for the extract of St. John's wort standardized to contain 0.3% hypericin)" - See iHerb or Vitacost SAMe products.
• Supplement SAM-e Helps Beat Depression - WebMD, 5/5/04 - "When SAM-e was added to their usual medication, half of the patients improved and 43% went into remission, Alpert reports. "These are quite strong responses and remission rates for a population that failed traditional therapy."" - See iHerb or Vitacost SAMe products.
• Zinc May Increase Antidepressant Therapy Effectiveness - Healthwell Exchange Daily News, 3/4/04 - "the zinc-supplemented group showed a statistically significant improvement compared with the placebo group at 6 and 12 weeks ... Other natural substances that have been shown to benefit depression sufferers include folic acid, DHEA, eicosapentaenoic acid (a fatty acid found in fish oil), and St. John’s wort" - See iHerb or Vitacost zinc products.
• Herbal Combo Effective for Mild Depression - Clinical Psychiatry News, 2/04 - "84% of patients who received the herbal preparation had a 50% reduction in the Hamilton Depression (HAM-D) rating scale scores vs. 18% among those on placebo ... Each patient received 360 mg/day of St. John's wort, 168 mg/day of valerian, and 192 mg/day of passion flower"
• High Vitamin B12 Levels May be Linked to Better Treatment Outcome for Major Depressive Disorder - Doctor's Guide, 1/5/04 - "Low levels of folate have also been associated with a poor response to antidepressive therapy ... patients with greater HDRS responses had higher vitamin B12 levels both at baseline (r = 0.39, P < .001) and at 6 months ... The positive relationship between higher vitamin B12 levels and improved HDRS score was also confirmed by linear regression analysis" - [Abstract] - See iHerb or Vitacost Vitamin B12 products.
• High vitamin B12 level and good treatment outcome may be associated in major depressive disorder - BMC Psychiatry. 2003 Nov 27 - "Higher vitamin B12 levels significantly associated with a better outcome" - See iHerb or Vitacost Vitamin B12 products.
• Effect of zinc supplementation on antidepressant therapy in unipolar depression: a preliminary placebo-controlled study - Pol J Pharmacol. 2003 Nov-Dec;55(6):1143-7 - "Zinc supplementation significantly reduced scores in both measures after 6- and 12-week supplementation when compared with placebo treatment. This preliminary study is the first demonstration of the benefit of zinc supplementation in antidepressant therapy. The mechanism(s) may be related to modulation of glutamatergic or immune systems by zinc ion" - See iHerb or Vitacost zinc products.
• Exercise Boosts Drug Treatment for Depression - Doctor's Guide, 11/10/03
• Dietary Folate and Depressive Symptoms Are Associated in Middle-Aged Finnish Men - J Nutr. 2003 Oct;133(10):3233-3236 - "The participants were grouped into thirds according to their dietary folate intake. Those in the lowest third of energy-adjusted folate intake had a higher risk of being depressed [odds ratio (OR) 1.67, 95% CI = 1.19-2.35, P = 0.003] than those in the highest folate intake third ... There were no associations between the intake of cobalamin, pyridoxine or riboflavin, and depression. These results indicate that nutrition may have a role in the prevention of depression" - See iHerb or Vitacost folic acid products.
• Supplements to Balance Mood - Natural Foods Merchandiser, 10/03
• St. John's Wort -  Natural Foods Merchandiser, 10/03 - "Recently, in a large trial comparing SJW with the conventional antidepressant imipramine, researchers concluded SJW is as effective as imipramine and is better tolerated by patients.13 In a newer, larger trial (240 participants) comparing SJW directly with fluoxetine, researchers concluded SJW was as effective and safer than fluoxetine, particularly in patients suffering depression and anxiety" - See Kira® (LI 160 extract) St. John's wort at iHerb.
• The Omega Principle - WashingtonPost.com, 8/19/03 - "Omega-3s, dubbed the "happy" fats in some quarters, are under investigation for treating depression, bipolar disease, attention-deficit hyperactivity disorder, alcoholism, Alzheimer's disease and even the so-called baby blues, or postpartum depression ... there are many profound neurological disorders that are known to be caused by lipid problems ... The brain itself, is, in fact, about 60 percent fat ... while the body can manufacture saturated fat, cholesterol and even some unsaturated fat -- it is incapable of producing two of the fatty acids that are most vital ... there has been an 1,000-fold increase in [consumption of] omega-6 fatty acids ... Flooding brains and bodies with a diet rich in omega-6 fatty acids theoretically could give an unfair advantage to these molecules, allowing them to block omega-3s from getting inside cells" - See Mega Twin EPA at Vitacost or iHerb.
• Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial - Eur Neuropsychopharmacol. 2003 Aug;13(4):267-71 - "In this study, we conducted an 8-week, double-blind, placebo-controlled trial, comparing omega-3 PUFAs (9.6 g/day) with placebo, on the top of the usual treatment, in 28 patients with major depressive disorder. Patients in the omega-3 PUFA group had a significantly decreased score on the 21-item Hamilton Rating Scale for Depression than those in the placebo group" - See Mega Twin EPA at Vitacost or iHerb.
• Higher Folate Levels Correlate with Improved Outcome for SSRI-Treated Geriatric Patients - Doctor's Guide, 7/16/03 - "Geriatric patients who are treated with the selective serotonin reuptake inhibitor (SSRI) sertraline appear to experience greater improvement in depression if they have higher than normal folate levels at the start of therapy"
• A New Era for SAMe - Life Extension Magazine, 6/03
• Lavender Effective Add-on Therapy for Depression - New Hope Natural Media, 5/8/03 - "the group taking the combination of imipramine and lavender had a significantly greater reduction in HAM-D scores and the antidepressant effect occurred more rapidly, compared with those taking imipramine or lavender alone" - See iHerb or Vitacost lavender products.
• Low Folate Concentrations Associated With Depression - Doctor's Guide, 5/2/03 - "Physically healthy people who are depressed have detectably lower folate status than those who are not depressed" - See iHerb or Vitacost folic acid products.
• Depression and Folate Status in the US Population - Psychotherapy and Psychosomatics 2003;72:80-87 - "Low folate status was found to be most characteristic of recently recovered subjects, and a large proportion of such subjects were folate deficient. Conclusions: Low folate status was detectable in depressed members of the general US population. Folate supplementation may be indicated during the year following a depressive episode" - See iHerb or Vitacost folic acid products.
• Bright Light Therapy May Boost Testosterone - WebMD, 4/22/03 - "early morning light therapy caused a surge in a pituitary hormone called luteinizing hormone (LH) that raises testosterone levels in men ... Previous studies have shown that bright light therapy of daily exposure to specially designed, high-intensity light boxes can alleviate many symptoms of depression, especially among people who suffer from seasonal affective disorder (SAD) during winter months" - I did a lot of research on lighting for our home owners association.  See http://qualitycounts.com/fp/lights.htm.  The closest fluorescents to actual sunlight are probably the ones with 5000 or 6500 Kelvin rating.  The lights advertised as "cool white" are around 3000 Kelvin.  I've always felt that the "cool white" phase was just a gimmick to sell what was cheap to make.
• Chromium Effective for Common Type of Depression - New Hope Natural Media, 4/10/03 - "15 people suffering from atypical depression, who had been off of antidepressant medication for at least seven days, were randomly assigned to receive chromium picolinate or a placebo for eight weeks. The dose was 400 mcg per day for the first two weeks, then 600 mcg per day for the remainder of the study ... Seventy percent (7 of 10) of those receiving chromium responded to the treatment, whereas none of the five individuals in the placebo group had a positive response. Although the number of participants in the study was small, the difference in outcome between the chromium and placebo groups was highly statistically significant. Moreover, in 60% of those receiving chromium, the depression went into remission" - See iHerb or Vitacost chromium products.
• Statins Appear To Have Favourable Impact On Psychological Conditions - Doctor's Guide, 4/2/03 - "the longer people are on the statins the more their symptoms of depression, anxiety and hostility decrease ... When people stop taking statins or can not tolerate the medicine, their depression, anxiety and hostility returns to pre-statin levels" - Note:  Red yeast rice is a non-prescription statin.  See iHerb and Vitacost red yeast rice products.
• The Death of Anti-Aging Supplements? - Life Extension Magazine, 3/03 - "During these many trials, researchers routinely found that when taken daily, DHEA supplements effectively reduced depressive episodes and enhanced mood. In fact, according to one major study in the UK, as many as 67% of men and 82% of women reported a noticeable decrease in their depressive symptoms while taking as little as 25 mg/day of DHEA"
• Dehydroepiandrosterone Augmentation in the Management of Negative, Depressive, and Anxiety Symptoms in Schizophrenia - Archives of General Psychiatry, 2/03 - "Results indicated significant improvement in negative symptoms (P<.001), as well as in depressive (P<.05) and anxiety (P<.001) symptoms in individuals receiving DHEA. This effect was especially noted in women"
• Fatty Acid Effective against Depression - New Hope Natural Media, 1/9/03 - "E-EPA is a chemically modified form of EPA ... the best results were achieved with the smallest amount of E-EPA tested ... The authors of the study speculated that taking too much E-EPA might cause an imbalance between the two major classes of essential fatty acids: the omega-3 class (which includes EPA) and the omega-6 class (which includes linoleic and arachidonic acids ... E-EPA is not widely available at the present time"
• S-Adenosyl-L-Methionine Results Similar to Imipramine in Major Depression - Doctor's Guide, 12/30/02 - "A total of 146 patients received 400 milligrams per day of intramuscular SAMe and 147 received 150 mg/d of oral imipramine ... SAMe and imipramine did not differ significantly on any efficacy measure, either main or secondary ... Adverse events were significantly less in patients treated with SAMe compared to those treated with imipramine" - Note:  There seems to be conflicting studies on whether oral SAMe is poorly absorbed.  I've added absorption studies near the bottom of my SAMe page.
  • SAM-e (S-Adenosylmethionine) - James South - "Because SAMe tablets are enterically coated, they should NOT be cut in half to achieve a lower dose- the SAMe may then break down before absorption"
• SAMe Beneficial in Treating Osteoarthritis, Depression, and Liver Disease - New Hope Natural Media, 12/12/02 - "More than 100 human studies have been published in medical journals showing that SAMe is a safe, effective treatment and, in the cases of depression and osteoarthritis, works as well as conventional medications"
• Mechanisms Differ Between Depression and Either Vitamin B12 Or Folate - Doctor's Guide, 12/10/02 - "hyperhomocysteinemia, vitamin B12 deficiency and, to a lesser extent, folate deficiency all were related to depressive disorders"
• Supplement [SAM-e] Found Effective As Antidepressant - Intelihealth, 11/6/02 - "The dietary supplement SAMe is about as effective as older, conventional antidepressants in treating depression, a preliminary, government-funded study says. It also finds SAMe to be comparable to non-steroidal anti-inflammatory medications in treating the pain of osteoarthritis. Such drugs include aspirin, ibuprofen and naproxen" - See iHerb or  Vitacost SAM-e products.
• Fish Oil Eases Depression - WebMD, 10/18/02 - "people who added a daily dose of omega-3 fatty acids to their regular antidepressant treatment had significant improvement in symptoms, including anxiety, sleeping problems, sadness, decreased sexual desire, and suicidal tendencies ... Previous studies have suggested that depressed people have lower-than-normal levels of a fatty acid known as EPA (eicosapentaenoic acid), which plays an important role in maintaining normal brain function" - See my essential fatty acids page, my omega-3 page or Mega Twin EPA at Vitacost or iHerb.
• Fish Oil May Help Relieve Stubborn Depression - Reuters, 10/17/02 - "Daily supplements of an omega-3 fatty acid--found in fish and fish oil--may help alleviate the symptoms of depression in patients who do not respond to standard antidepressant medications, new research findings suggest ... Previous researchers have suggested that the balance of omega-3 fatty acids in the brain may become skewed in people with depression, and earlier studies have shown that fish oil supplements can help alleviate the symptoms of schizophrenia and bipolar disorder, or manic depression"
• Extending Healthspan: Hormones, Supplements, Diet and Exercise - Life Extension Magazine, 10/02 - "Finally, the authors note that testosterone is an excellent antidepressant. It restores good mood, self-confidence and sociability, often making antidepressants such as Prozac no longer necessary. “Grumpy old men” are those with testosterone deficiency" - See Forever Ageless at Amazon.com
• Government Report Concludes: Dietary Supplement SAM-e Equally Effective as Prescription Drugs for Depression, Osteoarthritis - Vitacost/Business Wire, 10/3/02
• Straight Talk on Natural Depression Remedies - Natural Foods Merchandiser, 10/02
• Testosterone Deficiency & Depression, Does DHEA Raise the Levels of Bioavailable Testosterone in Men? - Life Extension Magazine, 8/02 - "As testosterone replacement for women is becoming increasingly commonplace, women too report not just restored libido, but also improved mood and greater energy, less anxiety and more assertiveness ... low levels of free testosterone were the best predictor of depression, regardless of age ... the study [in men] showed no correlation between depression and free estradiol ... The mood-improving action of testosterone is more likely to be due to the direct action of testosterone on the brain-possibly through raising the levels of dopamine, a very important "reward" neurotransmitter ... a well-controlled study published in the prestigious Journal of Clinical and Experimental Endocrinology and Metabolism did in fact find a significant rise in free testosterone in men aged 60 to 84 years, after three months on 100 mg of DHEA"
• Bright-Light Therapy Effective In Non-Seasonal Depression - Doctor's Guide, 5/23/02
• Adjunct Folinic Acid For Depressed Patients With Inadequate SSRI Response - Doctor's Guide, 5/8/02 - "Investigators report that patient folate levels rose. Hamilton Depression Rating Scale-17 (HAM-D-17) scores among 16 patients who completed the study decreased"
• Experiments Strengthen Link Between Fish Oil, Mental Problems - Intelihealth, 4/18/02 - "Infant monkeys fed baby formulas supplemented with omega-3 fatty acids - the ones found in "fish oil" - were stronger and more alert even at less than a week old than monkeys given standard baby formula ... Harvard researchers gave two groups of persons who had recently been hospitalized with depression diets that were high in omega-3 and omega-6, respectively. The results were so dramatic that after three months, the scientists were directed by a research oversight committee to stop the experiment and allow all the subjects to take omega-3" - Personal recommendation Mega Twin EPA at Vitacost or iHerb.
• Salmon May Help Relieve Depression - WebMD, 3/15/02 - "Patients randomly received either the fish oil capsule or a sugar pill in addition to the antidepressant medication they were taking ... After four weeks, six of 10 patients receiving E-EPA -- but only one of 10 receiving placebo -- had significantly reduced symptoms of depression ... The effect of E-EPA was significant from week two of treatment ... Depressed mood, guilt feelings, worthlessness, and insomnia were all improved" - Note: One softgel of Twinlab TwinEPA contains 600 mg of EPA (Eicosapentaenoic Acid).
• Low Melatonin Values, Melancholic Depression Linked - Doctor's Guide, 10/9/01 - see melatonin
• The Nature of Depression and Antidepressants - Nutrition Science News, 6/01
• St. John's Wort Vs. Drugs - Nutrition Science News, 6/01
• Exercise May Be A Viable Alternative To Antidepressants - Doctor's Guide, 9/22/00
• Polyunsaturated Fats and Neurological Disorders - Nutrition Science News, 9/00
• Fish May Lower Depression Risk - Intelihealth, 5/16/00
• St. John's Wort Passes Muster - Nutrition Science News, 4/00
• DHEA: A Mental & Physical Boost - Life Extension Magazine, 12/99
• Depression and DHEA Treatment - Life Extension Magazine, 10/27/99
• Magnetic Stimulation May Be A Safe Alternative To Shock Therapy - Doctor's Guide, 10/12/99
• The Marriage of DHEA and 5-HTP for New and Better Mood Function - Life Enhancement Magazine, 7/99
• DHEA, a better antidepressant - Life Enhancement Magazine, 7/99
• Catecholamines Kick Out the Demons of Depression - Life Enhancement Magazine, 7/99
• Fighting depression with needles and herbs - CNN, 7/21/99
• Natural Remedies for Depression - Nutrition Science News, 2/99
• Efficacy and Tolerability of Kava in Anxiety - Herb Research Foundation
• Fat in the diet may affect mental ability - CNN, 9/4/98
• S-Adenosylmethionine (SAMe) - Part 2: Fast-Acting Natural Antidepressant - Life Extension Magazine, 4/97

CME:

• Medscape depression CME courses
• Doctor's Guide depression CME courses
• Advances in the Treatment of Depression - Medscape, 6/29/05
• Long-term Management of Depression - Medscape, 6/29/05
• Update on the Treatment of Depression - Medscape, 3/23/05
• Advances in the Treatment of Depression: Clinical Implications of Dual-Acting Antidepressants - PowerPak.com, exp. 10/1/07
• Health Benefits of Folic Acid - PowerPak.com (CME), exp. 11/15/05 - "it was observed that rats fed a diet deficient in folic acid had significantly decreased serotonin content in the brain.25 It is now known that serotonin plays a role in the regulation of mood, and a deficiency of serotonin often is a factor in depression and mania"  - See iHerb or Vitacost folic acid products.
• Advanced Treatment of Major Depression - PowerPak.com, (CME course), exp. 12/15/06
• New Options in the Treatment of Depression - U.S. Pharmacist, exp. 11/30/05 - "When compared to fluoxetine, mirtazapine demonstrated significantly greater response rates at weeks 3 and 4. When compared to citalopram and paroxetine, mirtazapine showed significantly greater response in the first one to two weeks but not later. A comparison of mirtazapine and venlafaxine in hospitalized, severely depressed patients showed equal response and remission rates"
• Addressing Both the Emotional and Physical Symptoms in Depression - Medscape, exp. 3/21/04
• Clinical Update on the Treatment of Depression - Medscape, 9/18/02
• Recognizing and Treating Depression - The University of Mississippi School of Pharmacy and DRUG TOPICS, exp. 12/31/02
• Patient Satisfaction, Adherence, and Tolerance: Choosing the Right Antidepressant - Pragmaton Office of Medical Education, 4/11/01
• Treatment of Depression and Antidepressants -  American College of Physicians and the Office of Continuing Medical Education of the University of Virginia School of Medicine

General Information:

• Depression self-assessment - Mayo Clinic
• Depression - American Academy of Family Physicians
• Depression - emedicine.com
• Depression - familydoctor.org
• Patients With Severe Depression Improve Using Texas Medication Algorithm Project Guidelines - Doctor's Guide, 7/6/04 - "the level of improvement in the disease-management group was twice as much better when measured by a clinician and three times as much better when the patient described his or her own level of improvement"
• Why Are So Many Women Depressed? - Scientific America Women's Health: A Life Long Guide, Summer 1998 (see the subtopic "Stress and Cortisol") - "It is unclear whether depression is a cause or a consequence of elevated cortisol levels, but the two are undoubtedly related."
• Intelihealth depression page
• Depression - Veritas Medicine
• Atypical Depression - Clinical Psychiatry News, 3/03
• Books on depression - Amazon.com
• Treatments for depression - Medifocus.com

Depression and Endocrinology:

• Wilson's Thyroid Syndrome - "Conversion of T4 to T3 can also be impaired by glucocorticoids" - Maybe that is the mechanism by which cortisol causes depression, and if so, could T3 then cure the depression? - Ben, Related article:
• Symptoms Of Depression In Obese Children Linked To Elevated Cortisol - Science Daily, 6/11/09 - "There is evidence in adults that abnormal regulation of cortisol plays a role in both obesity and depression ... Cortisol levels in the saliva in the afternoon and evening correlated positively with symptoms of depression ... The more depressive symptoms that subjects reported, the higher the cortisol levels at those times"
• Neurogenesis In Adult Brain: Association With Stress And Depression - Science Daily, 8/31/08 - "Chronic stress can affect the brain and lead into depression"
• Depression can trigger diabetes, study suggests - MSNBC, 6/17/08 - "Depressed people were 42 percent more likely to develop diabetes ... depression also pushes up the levels of stress hormones such as cortisol ... Elevated cortisol levels can impair insulin sensitivity in the body and encourage belly fat, a risk factor for diabetes"
• Depression Associated With Low Bone Mineral Density - Medscape, 12/3/07 - "The novelty of this study is the fact that these women were not severely depressed ... Depression is considered a disease of chronic stress, Dr. Cizza said, with attendant increases in the stress hormone cortisol, and cytokines produced by the immune system. "Those substances are helpful to fight stress, but if there is too much cortisol or cytokines, there are side effects," he said. "One of the side effects is bone loss, so it was obvious to ask the question, 'do women with depression have low bone mass?'""
• l-thyroxine augmentation of serotonergic antidepressants in female patients with refractory depression - J Affect Disord. 2007 Feb 6 - "The study included 17 female patients ... After four weeks of l-thyroxine augmentation, the remission, assessed as 7 or less points on Hamilton Depression Rating Scale (HDRS) was obtained in eleven patients (64.7%). Five other patients (29.5%) had responded (reduction>50% on HDRS) and one patient did not show an improvement"
• Use OF T3 Thyroid Hormone to Treat Depression - DrMirkin.com - "some people become depressed when they take just T4 and their depression can be cured when they take both thyroid hormones, T3 and T4"
• Thyroid Supplementation Enhances Antidepressant Response - Medscape, 9/21/06 - "Remission occurred in 31 patients (58.5%) receiving T3 compared with 19 patients (38%) in the placebo group" - See T3 at International Anti-aging Systems but check with your doctor first.
• Salivary Cortisol Response to Prednisolone Challenge Helps Understand Treatment-Resistant Depression - Doctor's Guide, 9/19/06 - "prednisolone is a better corticosteroid than dexamethasone to assess the HPA axis because it binds to 2 different receptors, not only the glucocorticoid receptors but also the mineralocorticoid receptors, providing a more physiological approach"
• A Comparison of Lithium and T3 Augmentation Following Two Failed Medication Treatments for Depression: A STAR*D Report - Am J Psychiatry. 2006 Sep;163(9):1519-30 - "After a mean of 9.6 weeks (SD=5.2) of treatment, remission rates were 15.9% with lithium augmentation and 24.7% with T(3) augmentation" - See T3 at International Anti-aging Systems.
• Chronic Exposure To Stress Hormone Causes Anxious Behavior In Mice - Science Daily, 4/17/06 - "Scientists already knew that many people with depression have high levels of cortisol, a human stress hormone, but it wasn't clear whether that was a cause or effect. Now it appears likely that long-term exposure to cortisol actually contributes to the symptoms of depression" - See my cortisol page for ways to reduce it.
• T3 augmentation of SSRI resistant depression - J Affect Disord. 2006 Feb 14 - "T3 augmentation was associated with a statistically significant drop (p<.003) in the mean HAMD at end of the three weeks compared to baseline scores ... T3 augmentation resulted in improvement of mood scores"
• Depression May Raise Women's Diabetes Risk - WebMD, 12/22/04 - "symptoms of depression were linked to greater levels of insulin resistance among the women ... depression can alter hormones relating to how the body handles stress. This in turn can affect body fat distribution and how it handles blood sugar metabolism"
• Atypical Depression: Thyroid Link Still Alive - WebMD, 3/15/04
• Algorithm-Based Treatment Shows High Lack Of Response To Selective Serotonin Reuptake Inhibitors - Doctor's Guide, 4/17/03 - "When the clinicians added T3, they found it was effective among 10 out of 16 women patients (62.5%), but was not effective in any of the 9 male patients who received it. Although values were within the normal range, patients who responded to T3 had higher serum thyroid-stimulating hormone levels than those who did not ... The effect of T3 may be related to thyroid function even within the normal range"
• Mirtazapine Attenuates Hypothalamic-pituitary-adrenocortical Axis Hyperactivity in Depressed Patients - Doctor's Guide, 4/17/03 - "it has been shown to have an acute inhibiting effect on cortisol secretion in healthy subjects ... Apparently, mirtazapine rapidly attenuates HPA axis hyperactivity in depressed patients via direct pharmaco-endocrinological effects. However, this amelioration of HPA system dysregulation is not necessarily related to clinical improvement" - Click here for a previous study.
• Treatment of Subclinical Hypothyroidism Advocated - Doctor's Guide, 4/7/03 - "Adverse effects fall into four general categories, according to Dr. Gardner -- neuropsychiatric symptoms, abnormal lipids, altered myocardial function, and greater risk of atherosclerotic heart disease ... Adding to the controversy, he added, is growing evidence that the upper limit of normal serum TSH concentration should be less than 2.5-3.0 U/mL and not the current levels of 5.0-5.5 U/mL"
• Sleep-Endocrine Changes Could Be Most Prominent In Postmenopausal Major Depression Patients - Doctor's Guide, 3/7/03
• Testosterone Gel Could Help Depressed Men With Low Testosterone Levels - Doctor's Guide, 1/8/03
• Testosterone May Help Depressed Men - WebMD, 1/3/03 - "nearly half of the men who had not responded to conventional depression treatment had low or low-to-normal testosterone levels. And several showed dramatic improvement when the male hormone was given along with antidepressants"
• Depression Management - ContinuingEducation.com, exp. 12/31/02 - See table six, recommends 5 - 50 mcg T3, 100 mcg (.1 mg) T4
• New Vistas in Antidepressant Development - Medscape, 11/21/02 - "The evidence for corticotropin-releasing factor (CRF) hypersecretion in depression and certain anxiety disorders is compelling ... CRF is transported to the anterior pituitary via the hypothalamo-hypophyseal portal system where it promotes the release of adrenocorticotropic hormone (ACTH) into the general circulation, which in turn stimulates the production and release of cortisol from the adrenal cortex ... Numerous studies have revealed that the direct injection of CRF into the CNS of laboratory animals produces effects reminiscent of the cardinal symptoms of depression, including decreased libido"
• Bipolar Patients Sensitive to Thyroid Function Variations - Doctor's Guide, 1/8/02 - "They studied 65 patients in the depressed phase of bipolar I disorder to test the hypothesis that patients with lower thyroid function, even within the normal range, might have a poorer response to treatment initially ... Outcomes were relatively poor unless patients had FTI [free thyroxine index] values above the median and TSH values below the median"
• Cortisol Feedback Could Be Normal in Major Depression Patients - Doctor's Guide, 1/2/02
• Thyroid Hormones Accelerate Depressive Response to Drug Therapy - Doctor's Guide, 10/30/01 - "Five of the six studies found T3 to be significantly more effective than placebo in accelerating clinical response ... Investigators say they found that the average effect was highly significant"
• Researchers Explore New Meds for Mood Disorders - Clinical Psychiatry News, 10/01 - "Another approach being developed for patients with high levels of circulating cortisol involves the abortion pill mifepristone ... The findings, to be published this month in the Journal of Clinical Psychopharmacology, suggest that a rapid antidepressant response (approximately 7 days) may occur in some patients"
• Researchers Hopeful Antidepressant Augmentation Will Improve Remission - Clinical Psychiatry News, 9/01 - "In psychotic depression, a corticosteroid antagonist looks most promising. Mifepristone, which is used to induce abortions but was originally designed as treatment for Cushing's disease, has achieved rapid reversal of symptoms in some 30 psychotically depressed patients, ostensibly by blocking cortisol receptors. The drug is now being investigated in a large double-blind trial, he said"
• Major Depression: Tianeptine At Least Halves Relapse And Recurrence Rates - Doctor's Guide, 3/29/01 - "A smaller proportion of the tianeptine group experienced either relapses or recurrences compared to placebo (16 and 36 percent, respectively) ... events related to treatment were rare and mild in both arms of the study ... The rates of relapse and recurrence decreased between two- and three-fold among tianeptine users compared to placebo. However, the treatments were equally well accepted by the two groups" - note: tianeptine is believed to inhibit cortisol - Ben
• Depressed Patients Show Thyroid Resistance To Thyrotropin Action - Doctor's Guide, 2/6/01
• Serum Thyrotropin Concentrations and Bioactivity During Sleep Deprivation in Depression - AMA, 1/01
• Mirtazapine Regulates Stress Hormones, Improves Sleep In Depressed Patients - Doctor's Guide, 8/8/01 - "Mirtazipine might be the best option for depressed patients with sleep disturbance and irregularities in stress hormone function ... Depression is often accompanied by sleep disturbance -- subjective and objective -- as well as [hypothalamic-pituitary-adrenal] HPA-axis dysregulation ... Mirtazapine is a treatment that [profoundly affects] the HPA-axis within hours and promotes sleep within days ... They tested the 24-hour urinary free cortisol (UFC) levels of 16 healthy men and 20 men and women with major depression ... mirtazipne significantly reduced UFC concentrations, which is often elevated in depressed patients"
• Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism - N Engl J Med. 1999 Feb 11;340(6):469-70 - "among 15 visual-analogue scales used to indicate mood and physical status, the results for 10 were significantly better after treatment with thyroxine [t4] plus triiodothyronine [t3]"
• Study Supports Role Of Anticort In Treating Alzheimer's, HIV - Doctor's Guide, 4/17/98 - "Cortisol's role as a cause of disease is most recently confirmed in a study to be published in the May issue of the journal Nature Neuroscience. Authored by Dr. Sonia Lupien of McGill University, the study reports that high levels of cortisol play a key role in Alzheimer's, memory loss, shrinkage of the brain and aging. Dr. Lupien also states that such illnesses might be prevented with medications to reduce elevated cortisol levels."
• RU-486 could aid variety of ills - MSNBC, 11/2/00 - "RU-486’s ability to block the action of a different hormone — cortisol — has prompted doctors to try it for psychotic depression. In addition to feeling sad and worthless, people with this devastating condition have distorted thinking and often suffer delusions or hallucinations. Many
  become suicidal.
  
  “They have very, very disturbing and crazy thoughts ... and they have no ability to suppress them,” said Joseph K. Belanoff, a California psychiatrist who is chief executive officer of Corcept Therapeutics Inc., a small pharmaceutical company. Corcept is sponsoring a study of RU-486 for psychotic depression.
  
  Several lines of evidence have led researchers to suspect that some of the symptoms of psychotic depression are caused by an excess of cortisol in the brain. Cortisol levels rise in response to stress and may be abnormally elevated in depressed individuals. Similar symptoms can occur in patients with Cushing’s syndrome, an overabundance of cortisol usually caused by a tumor, and RU-486 has cured the mental disturbance in some
  such cases.
  
  “Our feeling has been that a lot of the cognitive problems and delusions that you see in some of the patients are due to the [cortisol],” said Alan F. Schatzberg, chairman of the psychiatry department at Stanford University School of Medicine, where researchers are conducting a study that will test RU-486 on 30 patients with psychotic depression.
  
  RU-486 or other cortisol-blocking drugs “may be better alternatives than ... some of the typical treatments” such as antipsychotic drugs or electric shock therapy, he said."
• Two studies implying that cortisol is the cause, not the result of depression:
  • Hyper-Secretion of Cortisol Found in Depressed Patients - Doctor's Guide, 8/28/01 - "a dysfunction in 5-HT 1A receptor activity could be due to a hyper-secretion of cortisol" - Ref. for this article:
  • Hpa axis dysfunction in major depression: relationship to 5-ht(1a) receptor activity - Neuropsychobiology 2001;44(2):74-77 - "a dysfunction in 5-HT(1A) receptor activity could be due to a hypersecretion of cortisol"
  • Transcranial Magnetic Stimulation Offers Antidepressant Effects - Doctor's Guide, 9/4/01 - Note: It doesn't mention cortisol but the following study it references does:
  • The impact of repetitive transcranial magnetic stimulation on pituitary hormone levels and cortisol in healthy subjects - J Affect Disord 2001 Sep;66(1):83-88, - "These changes, in particular the decrease of cortisol levels, might explain in part the efficacy of rTMS"

Other News:

• Depression Raises Risk for Type 2 Diabetes - WebMD, 6/8/09 - "Depressed participants who were not being treated had significantly greater insulin resistance than study participants who were not depressed. But treatment for depression appeared to improve insulin sensitivity ... There are several theories about how depression may contribute to type 2 diabetes, but the most widely cited theory involves the stress hormone cortisol ... Cortisol is a key player in blood sugar metabolism and insulin sensitivity ... High cortisol levels are also associated with increased fat deposits around the abdomen, or belly fat, which is a risk factor for type 2 diabetes"
• Low free testosterone levels are associated with prevalence and incidence of depressive Symptoms in older men - Clin Endocrinol (Oxf). 2009 May 25 - "Free testosterone levels below 170 pmol/L are associated with depressive symptoms while free testosterone levels below 220 pmol/L (lowest quintile of our population) predict the onset of depressive symptoms"
• Depression Linked With Accumulation Of Visceral Fat - Science Daily, 4/28/09 - "Our results suggest that central adiposity – which is commonly called belly fat – is an important pathway by which depression contributes to the risk for cardiovascular disease and diabetes"
• Heart Disease Tied to Depression, Anger - WebMD, 3/9/09 - "Chronically angry or hostile adults with no history of heart disease may be 19% more likely than their peers to develop heart disease"
• Depression Lowers Blood Pressure, but Antidepressants Increase It - Science Daily, 3/3/09
• Physical Activity Improves Mood For People Serious Mental Illness - Science Daily, 1/14/09 - "even meager levels of physical activity can improve the mood of people with serious mental illnesses (SMI) such as bipolar disorder, major depression and schizophrenia"
• High Blood Pressure Is Related To Depression In Elderly Subjects - Science Daily, 10/29/08
• FDA OKs TMS Depression Device - WebMD, 10/8/08 - "TMS is much safer than ECT. Unlike ECT, TMS does not require sedation and is administered on an outpatient basis"
• Obesity And Depression May Be Linked - Science Daily, 6/2/08
• Smokers Have A 41 Percent Higher Risk Of Suffering Depression - Science Daily, 4/24/08
• Antidepressants Linked To Type 2 Diabetes, Study Suggests - Science Daily, 3/25/08 - "the risk of diabetes almost doubled for the patients who were using two types of therapies at the same time, tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs)"
• Treating SSRI-resistant Depression - Science Daily, 3/25/08
• Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men - Arch Gen Psychiatry. 2008 Mar;65(3):283-9 - "Participants with depression had significantly lower total and free testosterone concentrations than nondepressed men (P < .001 for both). However, they were also more likely to smoke and to have low educational attainment, a body mass index categorized as obese, a Mini-Mental State Examination score less than 24, a history of antidepressant drug treatment, and greater concurrent physical morbidity. After adjusting for these factors and for age, men with depression were 1.55 (95% CI, 0.91-2.63) and 2.71 (95% CI, 1.49-4.93) times more likely to have total and free testosterone concentrations, respectively, in the lowest quintile"
• Low Testosterone Levels Associated With Depression In Older Men - Science Daily, 3/4/08 - "men in the lowest quintile (20 percent) of free testosterone concentration had three times the odds of having depression compared to men in the highest quintile"
• Antidepressants No Better Than Placebo? - WebMD, 2/27/08
• Anti-depressants 'of little use' - BBC News, 2/26/08 - "the drugs helped only a small group of the most severely depressed, and in most cases had no more effect than taking a dummy pill ... even the positive effects seen on severely depressed patients were relatively small, and open to interpretation"
• Wearing Too Much Perfume May Indicate Depression - Science Daily, 1/3/08
• Natural Human Hormone As The Next Antidepressant? - Science Daily, 12/12/07 - "Epo also "has neuroprotective and neurotrophic effects in animal models and affects cognitive and associated neural responses in humans," suggesting that it may be a candidate in the treatment of depression"
• Mental Health Treatment Extends Lives Of Older Patients With Diabetes And Depression - Science Daily, 12/5/07 - "Researchers at the University of Pennsylvania School of Medicine report that older adults with diabetes and depression are half as likely to die over a 5-year period when they receive depression care management than depressed patients with diabetes who do not receive depression care management"
• Mild Depression Tied to Bone Loss - WebMD, 11/26/07 - "Even mild depression may significantly increase a woman's risk for developing osteoporosis ... An inflammatory protein that has specifically been linked to bone loss -- interleukin-6 -- was found to be significantly elevated in the women with depression"
• Depression Linked To Bone-thinning In Premenopausal Women - Science Daily, 11/26/07 - "The researchers found that 17 percent of the depressed women had thinner bone in a vulnerable part of the hip called the femoral neck, compared with 2 percent of those who were not depressed"
• Non-drug Treatment Effective For Major Depression, Study Suggests - Science Daily, 11/23/07
• FDA OKs Abilify for Depression - WebMD, 11/20/07
• Abilify(R) (Aripiprazole) Approved by U.S. FDA for Add-On Treatment of Major Depressive Disorder - Doctor's Guide, 11/20/07 - "taking Abilify plus an ADT provided superior improvement in depressive symptoms to ADT alone at study endpoint (week six), as measured by the reduction of the MADRS Total Scores.3 For the secondary endpoint, Abilify plus an ADT was also superior to placebo plus ADT in reducing the mean SDS Total Score in one study"
• Antipsychotic Drug May Treat Depression - WebMD, 11/2/07 - "depression was in remission for about 24.5% of the Risperdal patients, compared with almost 11% of those taking the placebo"
• Uncertainties Prevail on Psychotic Depression - Clinical Psychiatry News, 11/07
• Workers' Depression: 21 Fields Ranked - WebMD, 10/16/07
• Depression And Cardiovascular Disease - Science Daily, 10/15/07
• Personal care, restaurant workers most depressed - USATODAY.com, 10/13/07 - "Almost 11% of personal care workers — which includes child care and helping the elderly and severely disabled with their daily needs — reported depression lasting two weeks or longer ... Workers who prepare and serve food — cooks, bartenders, waiters and waitresses — had the second highest rate of depression among full-time employees at 10.3%"
• Which antidepressants have demonstrated superior efficacy? A review of the evidence - Int Clin Psychopharmacol. 2007 Nov;22(6):323-329 - "Criteria were defined to judge the strength of evidence. Two pivotal studies in moderate-to-severe major depressive disorder that demonstrate superiority on the primary efficacy measure, or alternatively one pivotal study supported by consistent results from meta-analyses, was considered to constitute evidence for definite superiority. Three antidepressants met these criteria: clomipramine, venlafaxine, and escitalopram. Three antidepressants were found to have probable superiority: milnacipran, duloxetine, and mirtazapine. Only escitalopram was found to have definite superiority in the treatment of severe depression; probable superiority was identified for venlafaxine and possible superiority for milnacipran and clomipra"
• Depression Worsens Health More Than Angina, Arthritis, Asthma, Diabetes - Doctor's Guide, 9/14/07 - "Depression produces the greatest decrement in health compared with the chronic diseases angina, arthritis, asthma, and diabetes"
• Depression Associated With Accelerated Bone Loss in Older Women - Medscape, 6/29/07 - "We found that depressive symptoms were associated with greater rates of bone loss in a group of older women (average age about 75 years old); the more depressive symptoms women had, the greater their rates of bone loss"
• Depression May Trigger Diabetes In Older Adults - Science Daily, 4/23/07 - "Carnethon theorizes that the culprit responsible for diabetes in persons who are depressed is a high level of a stress hormone, cortisol"
• Depression May Be Related to Testosterone Levels in Men - Doctor's Guide, 11/13/06 - "Levels of TT were 11.94 among patients with major depression and 17.64 among healthy controls (P < .001). Bioavailable testosterone measures were 3.51 among patients with depression and 4.69 among controls ... Men with depression have a significantly lower BT level than do non-depressed men but using TT as the threshold to define hypogonadism revealed an even greater difference between the 2 groups in this study"
• Study Says Depression May Weaken Bones - WebMD, 10/30/06 - "After four weeks, the depressed mice had lost bone density, the study shows. The problem: They had a drop in bone-building cells called osteoblasts ... When the depressed mice drank water laced with imipramine, their depression eased and their bone loss stopped"
• Chronic Depression May Run in Families - WebMD, 9/8/06
• The Neurobiology of Treatment-Resistant Depression - psychiatrictimes.com, 9/1/07
• Strong Link Seen Between Depression, Inflammation - Clinical Psychiatry News, 6/06 - "depressed patients have elevated inflammatory markers—such as interleukin-6 and C-reactive protein. In fact, the levels of proinflammatory cytokines correlate with the severity of depressive symptoms in studies. In addition, administration of cytokine antagonists can effectively reverse depressive symptoms in patients"
• Chronic depression may rob you of more than joy: The evidence is piling up that it can also steal your health - US News, 4/10/06 - "depressed adults have a 37 percent greater risk of developing type 2 diabetes than the rest of the population; other studies have suggested their risk actually doubles ... One intriguing recent study of Alzheimer's patients revealed that those with a history of depression had more extensive plaques in their brains. Depressed postmenopausal women with no history of heart disease are much more likely to develop it and die of it than their peers ... loneliness can spike blood pressure by 30 points in older people. Pancreatic cancer, for reasons scientists don't understand, is often preceded by a serious depression before the disease asserts itself"
• History Of Depression Linked To More Brain Plaques And Tangles, Rapid Decline In Alzheimer's Disease - Science Daily, 2/8/06
• First Antidepressant Fails 70% of Time - WebMD, 1/4/06
• Drugs aid some depression sufferers - MSNBC, 1/2/06
• Link between Depression, Coronary Heart Disease - Doctor's Guide, 12/21/05
• Mildly Depressed People More Perceptive Than Others - Science Daily, 11/22/05
• Combination Therapy More Effective than Monotherapy for Treatment of Major Depressive Disorder - Doctor's Guide, 11/11/05
• Nerve-stimulation Therapy For Patients With Treatment-resistant Depression - Science Daily, 11/9/05
• Patients With Depression and Migraine Likely to Have More Serious Disease - Doctor's Guide, 10/11/05
• Depression, Epilepsy, and Suicide May Be Linked - WebMD, 10/10/05
• Symptoms of Depression May Worsen Heart Failure - Doctor's Guide, 9/12/05 - "depression may hasten the progression of heart disease by increasing the levels of a key protein that causes inflammation ... tumor necrosis factor alpha (TNF-alpha)"
• Symptoms Of Depression May Worsen Heart Failure - Science Daily, 9/8/05
• Vagus Nerve Stimulation Proves Effective for Treatment-Resistant Depression in Some Patients - Doctor's Guide, 8/31/05
• Nipping Depression in the Bud - WebMD, 8/19/05
• Depression Worsens Heart Disease - WebMD, 8/15/05 - "Patients who reported symptoms of depression did significantly worse on a test of blood vessel function"
• Drowsy Days May Signal Depression - WebMD, 8/12/05 - "After crunching the numbers, depression was the No. 1 risk factor for excessive daytime sleepiness. BMI came second. Typical sleep duration was third, followed by diabetes, smoking, and, finally, sleep apnea"
• Dopamine May Play New Role in Depression - WebMD, 7/28/05 - "Current antidepression treatments are mostly based on the deficiency or imbalance of the brain chemicals serotonin and norepinephrine ... This new study highlights the importance of the dopamine system"
• FDA OKs brain stimulator for depression - MSNBC, 7/15/05
• Drug Combination Shows Efficacy in Psychotic Depression - Clinical Psychiatry News, 7/05
• Insomnia May Precede And Prolong Major Depression - Doctor's Guide, 6/22/05 - "depressed patients with insomnia were nearly 11 times more likely to still be depressed at six months than those sleeping well, and 17 times more likely to remain ill after a year ... they suggest that targeted treatment for insomnia will increase the likelihood and speed of recovery from depression"
• Depression Treatment Fraught With Challenges - Clinical Psychiatry News, 4/05
• Symptom Scale Proves Superior In Finding Depression, Anxiety - Clinical Psychiatry News, 4/05
• Study Shows Strong Link Between Depression and Painful Complaints - Doctor's Guide, 3/10/05
• Depression Risk Worsens Through Generations - WebMD, 1/12/04
• Columbia Study Shows Depression Intensifies From One Generation to the Next - Doctor's Guide, 1/11/05
• Divorcing Depression - WebMD, 11/16/04
• Many Depressed Patients Have Bipolar Disorder - Medscape, 10/18/04 - "used the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) to reinterview 61 patients diagnosed with unipolar depression who had failed to respond to at least two adequate courses of antidepressants ... after following them for a year, fully 80% of patients were deemed to have bipolar disorder"
• Unhappy Marriage Reflects Spouse's Depression - WebMD, 10/11/04 - "each spouse's level of anxiety and depression predicted an unhappy marriage for the depressed spouse and the other spouse as well"
• Elevated Depressive Symptoms and Inflammation Seen in Heart Failure Patients - Doctor's Guide, 9/16/04 - "Activation of proinflammatory cytokines that occurs as a result of depression may promote the progression of heart failure and result in mortality in these patients"
• Depressed Patients May Need Treatment for Both Physical and Emotional Symptoms - Doctor's Guide, 9/9/04
• Abbreviated Depression Scale Proves as Effective as HAM-D17 - Clinical Psychiatry News, 9/04
• Study Links Depression and Pain - WebMD, 8/26/04
• Pain Common Side Effect of Depression - Doctor's Guide, 8/25/04
• Depression Linked to Overactive Brain Areas - WebMD, 8/6/04
• Depression Traced To Overactive Brain Circuit - Science Daily, 8/4/04
• Body Aches May Signal Depression - WebMD, 7/20/04 - "often, physical ills occur for no apparent reason -- and depression could be a likely cause ... Yet unless they are specifically screened for depression, it's hard for some doctors to pick up that it may be depression, especially in the primary care setting"
• Physical Symptoms Of Depression May Be Misdiagnosed - Doctor's Guide, 7/19/04
• Severe Depression Associated With Greater Number Of Nerve Cells In Thalamus Region Of Brain - Science Daily, 7/6/04
• Try Augmentation to Beat Fatigue in Depression - Clinical Psychiatry News, 6/04
• Primary Care for Depression Fails 50% of Time - WebMD, 5/6/04
• Schizophrenia Drug [Geodon] Used for Depression - WebMD, 3/24/04
• Depression, The Mind Body Connection - Physician's Weekly, 2/16/04 - "We are just beginning to realize the high number of patients coming to doctors with physical complaints that, at least in part, stem from depression. Approximately 12% of the general population is depressed, and among those with physical illness that number increases dramatically to maybe more than 40%; an astronomical number of ill patients are depressed ... People who are depressed are likely to have norepinephrine abnormalities; the proper functioning of blood macrophages is dependent upon health norepinephrine"
• Signs of Depression Put Heart at Risk - WebMD, 2/9/04
• Low Testosterone May Cause Depression - 2/3/04 - "some 30% of men over age 55 have it. Low levels of the hormone can cause symptoms of fatigue, a decreased sex drive, and irritability ...the men with low testosterone were four times more likely to be diagnosed with clinical depression" - [Abstract]
• Pain Hinders Depression Treatment - WebMD, 1/29/04
• Brain Structure Linked to Major Depression - WebMD, 1/29/04
• Riluzole Therapy Effective in Treatment-Resistant Depression - Medscape, 1/16/04
• Morning Headaches Linked to Depression - WebMD, 1/12/04
• Statins: A New Therapy for Depression? - Physician's Weekly, 12/8/03 - "adult patients with underlying coronary artery disease (CAD) who continuously used statins were 30% to 40% less likely to be at risk for depression, anxiety, and hostility"
• Even Mild Depression Harms Immunity - WebMD, 10/15/03
• Should Depressed Patients Take Antidepressants Longer? - Physician's Weekly, 8/25/03 - "depressed women had a smaller hippocampus ... women who remained on a medication for less time experience greater shrinkage of the hippocampus"
• Depression Hurts the Heavy Heart - WebMD, 8/22/03
• Oral Contraceptives and Depression - Medscape, 8/7/03
• Depression Liked to Alzheimer's Risk - Physician's Weekly, 7/28/03 - "People who have experienced depression are more likely to develop Alzheimer's disease than their relatives who have never shown signs of depression ... People who have experienced depression are more likely to develop Alzheimer's disease than their relatives who have never shown signs of depression"
• Gene Doubles Risk of Depression in Some - WebMD, 7/17/03
• Depression Most Costly Illness for Employers - Psychiatric News, 7/18/03 - "workers with depression cost employers more than three times the amount associated with lost productivity from all other illness ... Twenty percent of the $44 billion cost of depression was accounted for by absenteeism, while 80 percent of the costs associated with depression, or $35.7 billion, was linked to "presenteeism"—that is, present on the job but with significantly reduced productivity"
• Antidepressant Class Differentially Effective in the Treatment of Melancholic Depression - Doctor's Guide, 7/2/03
• Depression May Be Intracellular Rather Than Related To Serotonergic Or Noradrenergic Post-Synaptic Receptor Changes - Doctor's Guide, 6/19/03
• 80% Inadequately Treated for Depression - WebMD, 6/17/03 - "Most people with depression have moderate to severe forms of major depression. Only 10% of depressed Americans have mild, fleeting episodes ... The typical American with major depression is unable to work or perform everyday activities for 35 days each year. Those with the most severe major depression typically lose some 90 days each year"
• Clinical Depression Affects Work Productivity - WebMD, 6/17/03
• Remission Of Depression Linked With Sustained Improvement In Cognitive Function Following Stroke - Doctor's Guide, 6/17/03
• Identification Of Risk Factors In Depression In The Elderly Could Improve Public Health - Doctor's Guide, 6/16/03 - "Five factors - bereavement, sleep disturbance, disability, prior depression and female gender - have been identified as risk factors for depression in people aged fifty years or more"
• Some Teens Prone to Hopelessness Depression - Clinical Psychiatry News, 6/03
• Sexual Dysfunction Common But Conservatively Treated In Depressed Patients - Doctor's Guide, 5/26/03 - "Sexual dysfunction was observed in 35% of those spontaneously reporting problems and in 69% of those with problems identified by physician questioning. Of patients treated with antidepressants, 71% reported sexual dysfunction compared to 65% in untreated patients. The researchers also found that treatment with tianeptine was associated with a lower incidence of sexual dysfunction than was treatment with tricyclic antidepressant or serotonin reuptake inhibitors" - Interesting because depression is associated with high cortisol and tianeptine has been shown to counter the effects of cortisol.  That supports the theory of cortisol being the cause.  Tianeptine is available at IAS. - Ben
• New Test Detects Irritable Women - Doctor's Guide, 5/22/03
• Benefits Of Cognitive Behaviour Therapy May Be Overstated For Some Types Of Depression - Doctor's Guide, 5/20/03
• Men in Depression Denial? - Physician's Weekly, 5/19/03 - "A National Institute of Mental Health (NIMH) survey found that 32% of women receive treatment for depression as opposed to just 22% of men ... the disorder is often unrecognized and consistently under-treated"
• Alzheimer's Disease Linked to Depression - WebMD, 5/19/03
• Repercussions Of Concussions - CBS News, 5/5/03 - "Retired football players who suffered three or four concussions have twice the risk of later developing clinical depression — a risk that rises with even more injuries"
• Reduced Cortical 5-HT(2A) Receptor Binding Detected In Untreated Depression - Doctor's Guide, 5/2/03
• Pre-Clinical Characteristics Predict Increased Risk Of Late-Onset Depression - Doctor's Guide, 5/1/03
• Concussions May Boost Depression Risk - WebMD, 4/28/03
• New Stress-Buster Drugs Block Hormone Binding - Clinical Psychiatry News, 4/03 - "A new class of anxiety-relieving drugs—agents that interrupt core hypothalamic-pituitary-adrenal (HPA) stress signals—will emerge in the next 2-3 years ... In his HPA axis model of depression, the affected individual has a blunted ability to counterregulate in response to stress-induced cortisol increases, and thus is unable to turn off the fight-or-flight HPA mechanism. The result is constant anxiety and overreaction to external stimuli, followed by a sense of learned helplessness and loss of motivation. Many symptoms of deeply entrenched depression—anxiety, loss of appetite, reduced libido, elevated heart rate, hypertension, and dyslipidemia—point to HPA dysregulation ... People with melancholic depression do tend to produce abnormally high levels of CRH. These individuals also have elevated levels of cortisol" - See my cortisol page for ways to reduce it.
• Sleep Problems Don't Discriminate by Age - WebMD, 3/31/03 - "Sleep disorders were reported by: ... 82% of those with depression"
• Mom's Clinical Depression Risky to Kids - WebMD, 3/10/03
• Many Unhappy With Depression Treatment - WebMD, 3/7/03
• Depression Adds Weight, Which Can Clog Arteries - Intelihealth, 3/7/03
• Electroconvulsive Therapy More Effective Than Medication in Depression - Medscape, 3/6/03 - See my ECT page.
• Recurrent Major Depression Important Risk Factor For Carotid Plaque In Healthy Middle-Aged Women - Doctor's Guide, 3/3/03 - "Women with a lifetime history of recurrent major depressive episodes were more than twice as likely to have plaque on carotid ultrasonography than women with no history of major depression"
• Watch Out for Subsyndromal Depression - Clinical Psychiatry News, 3/03
• Chronic Painful Physical Conditions [CPPCs] Strongly Associated With Major Depression - Doctor's Guide, 2/19/03 - "A diagnosis of major depressive disorder was made in 4% of participants, and 43.4% of those with major depression had at least one CPPC. The researchers point out this was four times the rate in people without major depressive disorder"
• Ovarian Function Could Decline Early In Women With A History of Depression - Doctor's Guide, 2/19/03 - "Women with a lifetime history of major depression could have an early decline in ovarian function"
• Biological Marker [p-tau(231)] Could Differentiate Alzheimer's, Geriatric Depression - Doctor's Guide, 2/12/03
• Testosterone May Boost Efficacy Of Antidepressants in Men - Psychiatric News, 2/7/03
• Brief Depression Severity Measure Could Help Doctors Identify Severely Depressed Patients - Doctor's Guide, 1/29/03
• Smokers Face Highest Odds For Depression - Doctor's Guide, 1/20/03
• Depression And Chronic Pain Linked, May Influence Diagnosis, Treatment - Doctor's Guide, 1/16/03 - "A new study finds that people who have major depression are more than twice as likely to have chronic pain when compared to people who have no symptoms of depression" - See substance P.
• How Your Mind Can Heal Your Body - Time Magazine, 1/20/03 - "More and more doctors—and patients—recognize that mental states and physical well-being are intimately connected. An unhealthy body can lead to an unhealthy mind, and an illness of the mind can trigger or worsen diseases in the body. Fixing a problem in one place, moreover, can often help the other ... Somehow depression makes the body less responsive to insulin, the hormone that processes blood sugar—plausibly through the action of cortisol, a hormone that can interfere with insulin sensitivity and that is often elevated in depressed patients ... Cortisol may also make depressed patients more prone to osteoporosis ... Cizza estimates that some 350,000 women get osteoporosis each year because of depression. Cortisol appears to interfere with the ability of the bones to absorb calcium and offset the natural calcium loss that comes with menopause and aging"
• Structural Hippocampal Abnormalities Seen In Patients With Major Depression - Doctor's Guide, 1/15/03
• Testosterone Gel Helpful in Refractory Depression - Medscape, 1/15/03
• Depression, Early Perimenopause Linked - WebMD, 1/13/03
• Major Depression with Antidepressant-Associated Hypomania Could Be Bipolar III - Doctor's Guide, 1/13/03
• Alzheimer's Drugs Help More Than Memory - WebMD, 1/7/03 - "Four such drugs have been approved by the FDA for use in the U.S. -- Reminyl, approved in 2001; Exelon, approved in 2000; Aricept, approved in 1996; and Cognex, approved in 1993, but rarely used now because it can cause liver problems ... treatment with one of these drugs for at least one month slowed the worsening of functional skills such as the ability to dress, bathe and shop. And it improved psychiatric symptoms including depression, hallucinations, delusions, anxiety, and apathy"
• Testosterone Gel Could Help Depressed Men With Low Testosterone Levels - Doctor's Guide, 1/8/03
• Testosterone May Help Depressed Men - WebMD, 1/3/03 - "nearly half of the men who had not responded to conventional depression treatment had low or low-to-normal testosterone levels. And several showed dramatic improvement when the male hormone was given along with antidepressants"
• Cocaine Pains Brain - WebMD, 1/2/03
• Your Brain On Cocaine - CBS News, 1/1/03
• Three Depression Subtypes Respond Selectively - Clinical Psychiatry News, 1/03 - "Psychotic depression ... In general, the antidepressant needs to be helped along by an adjunctive antipsychotic agent or by ECT ... That constellation of symptoms known as atypical depression seems to preferentially respond to our old friends—the MAO inhibitors"
• Severity of Depression Linked to Modulation of Cardio-Vagal Activity - Doctor's Guide, 12/18/02
• Increased Mortality Risk Observed in Sub-Clinical Forms of Depression - Doctor's Guide, 12/11/02 - "The increased risk of mortality associated with depression exists not only in major depression but also in sub-clinical forms of the disease ... In many cases, depression should be considered as a life-threatening disorder"
• Depression Could Cost You Your Job - WebMD, 12/9/02 - "researchers found that 42% of those who showed symptoms of depression in the study's first year eventually lost their jobs"
• Epilepsy Aid [vagus nerve stimulation] May Ease Depression, Alzheimer's - Intelihealth, 12/9/02
• Genetic Factors in Depression More Important in Adolescents - Doctor's Guide, 12/6/02
• Brain Serotonin Production Directly Related To Degree Of Sunlight - Doctor's Guide, 12/5/02
• Unraveling the Sun's Role in Depression - WebMD, 12/5/02 - "regardless of the season, the turnover of serotonin in the brain was affected by the amount of sunlight on any given day. And the levels of serotonin were higher on bright days than on overcast or cloudy ones. In fact, the rate of serotonin production in the brain was directly related to the duration of bright sunlight"
• Depression One Consistent Predictor of Mortality in Older People - Doctor's Guide, 12/4/02
• Major Depression, Coronary Disease Link Still Mysterious - Clinical Psychiatry News, 11/02
• Depression: Genetic or Environmental? - WebMD, 11/4/02
• Adolescent Depression Common, Underreported to Physicians - Doctor's Guide, 10/28/02
• Antidepressant Treatment Of Depressed Patients After Hospital Discharge Inadequate - Doctor's Guide, 10/14/02
• Half Of Clinically Depressed Not Diagnosed - Intelihealth, 10/10/02 - "If you were depressed, you'd certainly know it, right? ... Well, maybe not ... Experts estimate that about half of the 20 million Americans who are clinically depressed, and could benefit from treatment" - I once read the the main reason most people take supplements is for increased energy.  I take them because I feel the anti-oxidants slow aging but I feel that a lot of those that are tired are really suffering from depression and don't realize it and therefore supplements aren't going to help much with there energy level.
• Use of a Calcium Channel Blocker in Depressed Patients - Medscape, 9/18/02
• Respiratory Sinus Arrhythmia May Help Predict The Clinical Course Of Major Depression - Doctor's Guide, 9/20/02
• Don't Ditch Your Antidepressants - WebMD, 9/17/02 - "It can take 9 months of treatment -- maybe up to a year -- to help prevent a relapse"
• Depression Associated With Mortality In Non-Ischaemic Heart Failure - Doctor's Guide, 9/6/02
• Repetitive Transcranial Magnetic Stimulation For Major Depression Increases Cortical Excitability Without Impairing Cognition - Doctor's Guide, 9/6/02
• Sleep Regulatory Changes Associated With Unipolar And Bipolar Depression May Be Different - Doctor's Guide, 8/30/02
• Predictors Identified For Early Recovery For Outpatients With Major Depression - Doctor's Guide, 8/30/02
• New Data Suggest Painful Physical Symptoms Are Common In Depression; Results Highlight Need For More Effective Recognition And Treatment - Doctor's Guide, 8/29/02
• Psychological Problems May Be More Valuable Than Sociodemographic Variables In Predicting Depressive Episodes - Doctor's Guide, 8/9/02
• Testosterone Deficiency & Depression, Does DHEA Raise the Levels of Bioavailable Testosterone in Men? - Life Extension Magazine, 8/02 - "Some men on testosterone drug replacement therapy develop dangerously high estrogen levels. Estrogen can be suppressed by taking an aromatase-inhibiting drug like Arimidex (0.5 mg twice a week) or using a supplement like Super Mira Forte (six capsules daily)"
• Depression May Be A Modifiable Risk Factor For Poor Compliance With Antihypertensive Therapy - Doctor's Guide, 7/31/02 - "the investigators found that depression was significantly associated with non-compliance with [antihypertensive] therapy"
• Patient Perception Of Illness May Mask Anxiety And Depression - Doctor's Guide, 7/10/02
• Modafinil May Reduce Residual Fatigue, Sleepiness - Clinical Psychiatry News, 7/02 - "Fatigue, sleepiness, and such related phenomena as impaired concentration and reduced energy are extremely common in depression, and may remain—sometimes for years—after the disorder has resolved ... There were significant declines in both sleepiness and fatigue in the medication [modafinil] group, compared with placebo, at the first week of treatment (for sleepiness) and the second (for fatigue)."
• Testosterone Therapy Improves Exercise Ability of Men with Chronic Congestive Heart Failure - Doctor's Guide, 6/21/02 - "After 12 weeks, the testosterone group achieved a 34 percent increase in exercise capacity compared to 2 percent for the control group ... In addition, the testosterone treatment improved depression and heart failure symptoms while causing few side effects"
• Hippocampal Volumes Could Have Remission Role In Geriatric Depression - Doctor's Guide, 6/12/02
• Platelet Activation Linked To Increased Cardiovascular Risk In Depression - Doctor's Guide, 6/5/02
• Resilience, talking can help kids beat depression - USA Today, 6/4/02
• Depression Linked to Parkinson's - WebMD, 5/28/02 - "About 1.4% (19) of the depressed people (about 1.4%) developed Parkinson's compared with only 0.4% of the others ... the link may have a biological explanation, known as the "serotonin hypothesis." Not only do people with Parkinson's disease have lower levels of dopamine in the brain, studies have also shown that the brains of these patients also have reduced levels of another brain chemical, serotonin. Low levels of serotonin are known to be a key factor in depression" - Note: St. Johns wort is believed to increase all three of the brain's primary chemicals, serotonin, norepinephrine and dopamine.
• Therapy as Good as Drugs for Depression - WebMD, 5/23/02
• Depression among college students rising - USA Today, 5/22/02
• Panel Pushes Depression Screening - Intelihealth, 5/21/02 - "They said doctors should start by asking patients two questions: "Over the past two weeks, have you felt down, depressed or hopeless?" and "Over the past two weeks, have you felt little interest or pleasure in doing things?" ... A yes answer to either question should be followed with in-depth questionnaires to determine whether the patient is depressed"
• Sleep Disordered Breathing Can Cause Depression - Doctor's Guide, 5/20/02
• Alcohol Hampers Depression Tx - Clinical Psychiatry News, 5/02
• Primary-Care Treatment Choices Outlined For Non-Major Depression - Doctor's Guide, 5/8/02 - "They add that individual trials suggest significantly greater improvements in symptom scores with venlafaxine [Effexor]"
• Parental Major Depression and the Risk of Depression and Other Mental Disorders in Offspring: A Prospective-Longitudinal Community Study - Archives of General Psychiatry, 4/02
• Smoke Gets In Your Mind - Intelihealth, 4/12/02 - "A growing band of researchers claim that smoking is the cause, not the consequence of clinical depression and several forms of anxiety"
• Depression Genes Differ Between Sexes - WebMD, 3/29/02
• Women and the Blues - WebMD, 3/21/02
• How Depressing: Low Mood Undertreated - WebMD, 3/11/02
• Nausea Sometimes A Red Flag For Anxiety and Depression - Doctor's Guide, 3/8/02 - "People who experience nausea may be suffering from anxiety or depression, possible causes that should be investigated before aggressive treatments are begun for gastrointestinal disorders"
• Older Women Have Tough Time With Depression - WebMD, 2/14/02 - "The message here is that older women who are being treated for depression, but are not getting better, might want to explore the option of estrogen replacement if the don't have any contraindications to it"
• Depression Harmful to Seniors' Health - WebMD, 2/13/02
• Depressive Symptoms Independently Predict Subsequent Hypertension - Clinical Psychiatry News, 2/02
• Persistent Mild Depression In Older Adults May Lower Immunity And Ability To Fight Off Disease, According To New Study - Intelihealth, 2/11/02
• Hunting the Cause of Winter Depression - WebMD, 1/23/02
• Dreams May Hold Key to Beating Depression - WebMD, 1/18/02
• Abortion Linked to Depression - WebMD, 1/17/02
• Depression And Anxiety Increase Risk Of Fatal Stroke - Intelihealth, 1/4/02
• Seasonal Affective Disorder Gives Some The Blues - Intelihealth, 12/19/01
• Vagus Nerve Stimulation Continues To Show Long-Term Benefits For Chronic Or Recurrent Depression - Doctor's Guide, 12/18/01
• Social Component Seen In Most Cases of Depression - Doctor's Guide, 12/18/01
• 3 Antidepressants Equally Effective - WebMD, 12/18/01
• New Depression And Anxiety Treatment Goals Defined - Doctor's Guide, 12/4/01
• Augmentation Strategy Aids Treatment-Resistant Depression - Clinical Psychiatry News, 11/01 - "Pramipexole, a dopamine agonist, may be an effective augmentation agent for patients with treatment-resistant depression"
• Estradiol Beneficial In Treating Some Menopausal Women With Depression - Doctor's Guide, 10/9/01
• Depression May Lurk in Stress-Response System - Clinical Psychiatry News, 9/01 - "Norepinephrine depletion has a particularly marked effect on concentration, energy, and interest, while mood is equally sensitive to this neurotransmitter and serotonin"
• Hyper-Secretion of Cortisol Found in Depressed Patients - Doctor's Guide, 8/28/01 - "a dysfunction in 5-HT 1A receptor activity could be due to a hyper-secretion of cortisol"
• Depression Makes Heart Failure Worse - WebMD, 8/13/01
• Wendy Williams dives into depression awareness - USA Today, 8/10/01 - "Depression is the number one cause of disability in the world, worse than heart disease, cancer, and car accidents"
• New Antidepressant Class May be On Its Way - Doctor's Guide, 8/9/01
• Antidepressant Effexor Good Choice for Older Women - WebMD, 8/7/01
• New Options for Severe Depression - WebMD, 7/23/01
• Symptoms of Teen Depression May Not Be What Parents Expect - WebMD, 7/16/01
• Depression and the Aging Man - WebMD, 6/27/01
• Depressive Symptoms In Diabetics Worsen Glycemic Control - Doctor's Guide, 6/25/01
• The Future is Now: You Can Control How Well You Age, Depression, Education Key Factors - WebMD, 6/1/01 - "However, if the seven controllable factors are in check, the only uncontrollable factor that is likely to wreak havoc with your older years is depression"
• Shock Therapy Takes on a New Form, Novel Technique Safe and Feasible, Even When Used to Cause Seizures - WebMD, 6/1/01
• Depression may double diabetes risk - USA Today, 5/24/01 - "But, even "independent of weight gain and other factors," Lustman says, depression doubles the risk for diabetes. "There are changes in hormones that occur during depression that can directly increase insulin resistance.""
• Women With Depression Have Special Needs, Considerations - WebMD, 5/17/01
• High Rate of Sustained Remission With Celexa (Citalopram HBr) Treatment For Depression - Doctor's Guide, 5/10/01
• Venlafaxine Improves Patients Depression-Free Days Compared To Selective Serotonin Reuptake Inhibitors, Placebo - Doctor's Guide, 5/10/01
• Consider Undertreatment in Resistant Depression - Clinical Psychiatry News, 4/01 - "Dosage should be pushed to the maximal tolerated level—something many psychiatrists are not prepared to do—and then maintained there for at least 6 weeks before an agent is concluded to be ineffective"
• Antidepressants Can Cause Bedroom Blues, Wellbutrin Fixes Antidepressant Sex Problems - WebMD, 4/18/01 - "as many as half of the men and women taking these drugs find that it affects their sex lives"
• Help Available for Depression Triggered by Interferon - WebMD, 3/29/01
• Study Showing High Relapse Rate Puts Spotlight On Electroshock Therapy - Intelihealth, 3/13/01 - "without follow-up medication, depression returned in 84 percent of patients within six months. Even with the best results - using an anti-depressant and anti-psychotic after ECT - 39 percent of patients relapsed"
• A fatal cycle of inactivity, blues - USA Today, 3/8/01 - "It's kind of a chicken-or-egg thing," Carney says. "Do you become depressed because you don't exercise, or do you not exercise because you're depressed? The arrow probably goes in both directions"
• Depression In Later Life May Be Caused By Hardened Arteries - Doctor's Guide, 12/20/00
• Seroquel (Quetiapine) Significantly Improves Depressive Symptoms In Schizophrenia, Other Psychotic Disorders - Doctor's Guide, 11/30/00
• Depressed? You May Be More Likely to Develop Heart Disease - WebMD, 10/9/00
• Popular Drug Ecstasy Not Harmless Like Many Users Think - WebMD, 7/24/00
• Depression May Up Stroke Risk, But It Can Be Treated - WebMD, 7/21/00
• Obsessive Internet use poses risk of isolation, depression, researchers say - CNN, 6/13/00
• Celexa (Citalopram) Helps Prevent Major Depression Recurrence In The Elderly - Doctor's Guide, 5/18/00
• Depressed Men Face Heart Risks - Intelihealth, 5/8/00
• Neuroscience finds foggy link between depression and memory loss - CNN, 4/18/00
• Low Cholesterol Associated With Depressive Symptoms - Doctor's Guide, 3/23/00
• Depression And Anxiety Increases Likelihood Of Hypertension - Doctor's Guide, 3/23/00
• Older Tricyclics More Effective Than Newer Antidepressants In Post-Stroke Depression - Doctor's Guide, 3/2/00
• Effexor More Effective Than Prozac In Achieving Remission In Depression - Doctor's Guide, 2/10/00
• Study indicates doctors need training to spot depression - CNN, 1/11/00
• Remeron Relieves Depression Quicker Than Do Some SSRIs - Doctor's Guide, 12/15/99
• Treat Depression First, Then AD/HD, Says Researcher - Doctor's Guide, 10/27/99
• Sexual Dysfunction Less Likely In Depressed Patients Taking Moclobemide - Doctor's Guide, 9/27/99
• Depression Commonly Misdiagnosed As Dementia - Doctor's Guide, 9/13/99
• New Study Links Depression And Heart Disease - Intelihealth, 3/25/99
• Study: Prozac no better than older depression drugs - CNN, 3/19/99
• Effexor XR Approved In The U.S. For Anxiety - Doctor's Guide, 3/11/99
• Epilepsy Drug Lamictal Appears Effective For Bipolar Depression - Doctor's Guide, 3/10/99
• Depression Linked To Reduced Blood Pressure Control - Doctor's Guide, 3/5/99
• Antidepressant-Induced Sexual Dysfunction Associated with Low Serum Free Testosterone
• Depression may lead to cancer, study finds - CNN, 12/16/98
• Remeron More Effective, Faster Working Than Cipramil or Paxil, Study Shows - Doctor's Guide, 11/3/98
• Paroxetine Shown To Be Effective In Treatment Of Severe Social Phobia - Doctor's Guide, 8/25/98
• Erectile Dysfunction Associated With Depression - Doctor's Guide, 7/23/98
• FDA Approves Celexa For The Treatment of Depression - Doctor's Guide, 7/20/98
• Study: Depressed men twice as likely to develop heart disease - CNN, 7/12/98
• Financial Strain A Major Cause Of Psychiatric Illness - Doctor's Guide, 7/10/98
• Remeron Found Superior To Fluoxetine In Early Depression Treatment - Doctor's Guide, 6/25/98
• Effexor XR Produces Significantly Higher Depression Remission Rates Than Prozac - Doctor's Guide, 6/2/98
• The Responsible Parent's Guide to Healthy Mood-Boosters for all the Family - BLTC Research
• Study Shows Migraine And Depression May Be Treated Together - Doctor's Guide, 4/30/98
• Antidepressant Can Change Personality Traits In Healthy People - Doctor's Guide, 3/2/98
• Treating Depression In Diabetics Helps Control Blood Sugar - Doctor's Guide, 6/6/97
• Link Between Sleep Quality and Depression Treatment An Important Issue - Doctor's Guide, 5/12/97
• NIMH Links Depression to Bone Loss - Doctor's Guide, 10/16/96

Related Searches:

• Books on depression at Amazon.com
• Doctor's Guide search of depression
• Doctor's Guide (2) search of depression
• Intelihealth search of depression
• Life Extension Foundation search
• Medline search of depression
• Medscape search of depression
• Google search of depression
• The Natural Pharmacist search of depression
• Nutrition Science News search
• WebMD search of depression

Related Sites:

• Depression Central
• Depression-Screening.org
• Intelihealth depression page
• Internet Mental Health
• Medscape Resource Center - Depression
• National Alliance for the Mentally Ill
• PsychResearch.com - Self-therapy for depression, phobias, anxiety, headaches, allergies, sleep problems, dyslexia, stage fright, etc.
• Postpartum Depression
• WebMD depression page
• Wing of Madness: Children and Depression

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