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Antidepressants & Psychotropics > Effexor® (venlafaxine (HCI)
Effexor® (venlafaxine HCl) (American Home Product's/Wyeth-Ayerst Laboratories)
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News & Research:
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Effexor (venlafaxine Hcl) - rxlist.com
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Analysis Shows Sertraline, Escitalopram More Effective Than 10 Other
New-Generation Antidepressants - Doctor's Guide, 1/29/09 -
"Sertraline and escitalopram were found to be the
best antidepressants overall in terms of efficacy and acceptability.
Sertraline was more efficacious than duloxetine (by 30%); than both
duloxetine and fluvoxamine (by 27% for both); 25% fluoxetine (by 25%);
paroxetine (by 22%); and reboxetine (by 85%) ... Escitalopram was more
efficacious than duloxetine (by 33%); fluoxetine (by 32%); fluvoxamine (by
35%); paroxetine (by 30%); and reboxetine (by 95%). As with sertraline and
escitalopram, mirtazapine and venlafaxine were also more efficacious than
these other drugs ... However, escitalopram and sertraline showed the best
profile of acceptability, leading to significantly fewer discontinuations of
treatment than did duloxetine, fluvoxamine, paroxetine, reboxetine, and
venlafaxine"
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Venlafaxine Extended-release Effective For Patients With Major Depression,
Study Suggests - Science Daily, 12/17/07
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New Warning on
Effexor Overdoses - WebMD, 10/25/06
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FDA OKs Generic
Antidepressant Effexor - WebMD, 8/9/06
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Updated Product Information for Efexor - Doctor's Guide, 5/31/06
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Study Reports Venlafaxine Extended Release May Help Adult Patients Prevent
New Episodes of Depression for Up to 2 Years - Doctor's Guide, 5/31/06
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Two Years of Venlafaxine XR Maintenance Prevents Recurrence in Patients With
Recurrent Unipolar Major Depression - Doctor's Guide, 5/29/06
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Bupropion XL and Venlafaxine XR for Treatment of Major Depression -
Doctor's Guide, 5/25/06
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Venlafaxine ER in Teens With Panic Disorder Appears Safe, But Caution Still
Advised - Doctor's Guide, 3/29/06
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Effexor XR (venlafaxine HCl) Approved for Treatment of Panic Disorder -
Doctor's Guide, 11/21/05
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New Study Compared Sexual Functioning of Patients Treated with Wellbutrin XL
(Bupropion) versus Effexor XR (Venlafaxine) - Doctor's Guide, 11/10/05
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Treatment with Serotonin-Norepinephrine Reuptake Inhibitor Reduces Rate of
Relapse in Panic Disorder - Doctor's Guide, 11/10/05
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Effectiveness of Venlafaxine (Effexor XR) in the Treatment of Depression is
Independent of Sex and Age - Doctor's Guide, 11/10/05
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Venlafaxine (Effexor XR) and Paroxetine Effective for Short-Term Treatment
of Panic Disorder - Doctor's Guide, 11/10/05
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Venlafaxine (Effexor XR) Improves Somatic and Psychic Symptoms in General
Anxiety Disorder - Doctor's Guide, 11/9/05
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Sustained-Release Venlafaxine Improves Symptoms in Post-Traumatic Stress
Disorder - Doctor's Guide, 10/31/05
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Relatively Greater Efficacy Achieved With Venlafaxine Compared to Selective
Serotonin Reuptake Inhibitors in Anxious Depression - Doctor's Guide,
6/2/05
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For Major Depression, Escitalopram (Lexapro) Achieves Better Risk/Benefit
Profile Than Venlafaxine XR (Effexor XR) - Doctor's Guide, 5/31/05
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Venlafaxine XR May Prevent Panic Disorder Relapse - Doctor's Guide,
3/23/05
- Venlafaxine May Be Effective in Social Anxiety Disorder - Medscape, 2/10/05
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Venlafaxine Extended-Release Might Be Effective for Depressed Adolescents But Should be Prescribed With Attention to Risks - Doctor's Guide, 10/28/04
- Lithium and Venlafaxine Both Helpful Adjuncts in Depressed Patients Unresponsive to Selective Serotonin Reuptake Inhibitors - Doctor's Guide, 10/19/04
- Venlafaxine Study Shows Greater Complete Symptom Resolution Rates Than With Selective Serotonin Reuptake Inhibitors - Doctor's Guide, 10/18/04
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Lithium Augmentation of Venlafaxine - Clinical Psychiatry News, 10/04
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Venlafaxine and Paroxetine Both Relieve Social Anxiety - Clinical Psychiatry News, 9/04
- Venlafaxine Associated With Neonatal Complications - Medscape, 6/29/04
- Sertraline HCl and Venlafaxine-XR Show Comparable Efficacy in Major Depression - Doctor's Guide, 6/23/04
- Venlafaxine Effective for Social Anxiety Disorder in Children and Adolescents - Doctor's Guide, 5/6/04
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Venlafaxine and Panic Disorder - Clinical Psychiatry News, 4/04
- Venlafaxine Extended Release (Effexor) Appears Safe and Effective in Treating Panic Disorder - Doctor's Guide, 3/16/04
- Treatment Adequacy Appears More Likely With Venlafaxine Extended Release Than Fluoxetine In Depressed Patients - Doctor's Guide, 2/10/04
- Venlafaxine Alleviates Pain and Disability Associated with Fibromyalgia - Doctor's Guide, 11/7/03
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Venlafaxine XR Holds Own in Panic Disorder - Clinical Psychiatry News, 10/03
- Venlafaxine and Selective Serotonin Reuptake Inhibitor Combination May Be Safe, Effective for Treatment-Resistant Depression - Doctor's Guide, 9/5/03
- Warning Issued For Kids Taking Effexor - WebMD, 9/4/03
- Wyeth Warns Of Kid Suicide Risk With Drug - Intelihealth, 9/4/03
- Venlafaxine Less Tolerated, Not As Safe in Elderly Depressed Patients - Doctor's Guide, 9/3/03
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Remission Rates Shown Higher With Venlafaxine Than SSRIs - Clinical Psychiatry News, 8/03 -
"Venlafaxine outperformed selective serotonin reuptake inhibitors in achieving remission in major depression, according to a pooled analysis of data from 33 randomized, double-blind, comparative clinical trials"
- Venlafaxine XR and Paroxetine Improve Physiological Symptoms of Panic Disorder and Social Anxiety Disorder - Doctor's Guide, 5/29/03
- Venlafaxine Works as Intermittent Therapy for Premenstrual Distress - Doctor's Guide, 5/26/03
- Venlafaxine XR and Paroxetine Combination Improves Physiological Symptoms of Panic Disorder and Social Anxiety Disorder - Doctor's Guide, 5/23/03
- Venlafaxine, Paroxetine, Both Work on Panic - Doctor's Guide, 5/22/03
- Venlafaxine Beats Selective Serotonin-Reuptake Inhibitors in Remission of Depression - Doctor's Guide, 5/22/03 -
"The results of this
largest-of-all comparative study of venlafaxine and other agents supports the conclusions of other investigators that, compared to other SSRIs, venlafaxine helps patients achieve remission of symptoms at relatively higher rates" - Note: Venlafaxine increases both
serotonin and norepinephrine, as does mirtazapine and the investigational drug duloxetine.
- Venlafaxine Helpful in Painful Polyneuropathy - Medscape, 5/8/03
- New Antidepressants Target Aches and Pains, Too - Psychiatric News, 4/18/03
- Venlafaxine XR Demonstrates Efficacy in Panic Disorder - Doctor's Guide, 4/1/03
- Venlafaxine XR as Effective as Paroxetine in Reducing Panic Attacks – Even in Patients with Severe Panic Disorder - Doctor's Guide, 3/31/03
- Venlafaxine XR Similar to Paroxetine for Treating Social Anxiety - Doctor's Guide, 3/31/03
- Venlafaxine XR Remains Effective for Social Anxiety Symptoms for Long-term - Doctor's Guide, 3/31/03
- Venlafaxine XR Effective and Well Tolerated in Posttraumatic Stress Disorder - Doctor's Guide, 3/30/03
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Venlafaxine XR Effective For GAD in Children - Clinical Psychiatry News, 3/03
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Two More Drugs Approved for Social Anxiety - Clinical Psychiatry News, 3/03
- FDA Approves Effexor XR (Venlafaxine HCl) For Treatment of Social Anxiety Disorder - Doctor's Guide, 2/12/03
- Questions Raised Over Venlafaxine As First Line Antidepressant Therapy - Doctor's Guide, 12/6/02
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More Remissions With Venlafaxine for Depression - Clinical Psychiatry News, 11/02
- Severe Gastrointestinal Symptoms Do Not Alter Efficacy of Venlafaxine in Generalised Anxiety Disorder - Doctor's Guide, 11/4/02
- Venlafaxine XR Data Shows Expanded Option for Social Anxiety - Doctor's Guide, 10/11/02
- Escitalopram Achieves Earlier Response and Better Tolerability than Venlafaxine XR in First Head-to-Head Study - Doctor's Guide, 10/8/02
- Remission in Patients With Depressive Symptoms: Venlafaxine and SSRIs Compared - Doctor's Guide, 9/2/02 -
"Venlafaxine/venlafaxine XR demonstrated significantly higher remission rates than
SSRIs or placebo in patients diagnosed with depression for both = 52 weeks and =
52 weeks"
- Venlafaxine Appears More Effective Than Fluoxetine In Treating Depression With Concomitant Anxiety - Doctor's Guide, 8/9/02 -
"An overall response was seen in 75 percent of patients receiving venlafaxine and 51 percent of patients receiving fluoxetine. At their final visit, 59 percent of patients taking venlafaxine and 40 percent taking fluoxetine were virtually asymptomatic"
- Venlafaxine XR Safe, Effective for Pediatric Patients with Generalized Anxiety Disorder - Doctor's Guide, 6/27/02
- Effexor (Venlafaxine) More Effective In Reducing Depression - Doctor's Guide, 6/5/02 -
"In a large analysis comparing selective serotonin reuptake inhibitors (SSRIs) and
tricyclics (TCAs) to Effexor® (venlafaxine), a serotonin noradrenaline reuptake inhibitor (SNRI),
the antidepressant Effexor was found to be more effective than 10 other medications, including all the SSRIs studied"
- Antidepressant [Effexor] Treats Severe Anxiety in Children - WebMD, 5/29/02
- Venlafaxine Achieves Long-Term Remission in Patients with Recurring Depression - Doctor's Guide, 5/22/02
- Venlafaxine Effective for Children with Generalized Anxiety Disorder - Doctor's Guide, 5/22/02
- Venlafaxine Equals Paroxetine for Obsessive-Compulsive Disorder - Doctor's Guide, 5/21/02
- Primary-Care Treatment Choices Outlined For Non-Major Depression - Doctor's Guide, 5/8/02 -
"They add that individual trials suggest
significantly greater improvements in symptom scores with venlafaxine [Effexor]"
- Which Antidepression Drug Is Best? - WebMD, 4/30/02 -
"As initial therapy for depression, most doctors tend to use newer drugs that target a
specific brain chemical -- serotonin -- involved in depression. These drugs, called selective serotonin reuptake inhibitors or
SSRIs ... Effexor does this, too, but it isn't quite as specific. It also increases the amount of another chemical --
norepinephrine -- in the brain ... Those who received Effexor were 43% more likely to have their depression go into remission than those taking SSRIs"
- Venlafaxine Reduces Menopausal Symptoms in Breast Cancer Survivors Who Cannot Take Estrogen - Doctor's Guide, 10/8/01
- Doctors Target Two Brain Chemicals to Treat Depression, Anxiety - WebMD, 9/17/01 -
"Prozac works by increasing the availability of the mood chemical serotonin, while Effexor
targets serotonin and norepinephrine, another brain chemical that plays a role in anxiety and depression ... there's a whole series of other studies in the area of anxiety disorders and new medications that are in development that target both brain chemicals ... One such drug, Remeron, is currently available"
- Antidepressant Effexor Good Choice for Older Women - WebMD, 8/7/01
- Venlafaxine Extended-Release Provides Rapid, Long-Term Treatment of Generalized Anxiety Disorder - Doctor's Guide, 7/3/01
- Venlafaxine Improves Patients Depression-Free Days Compared To Selective Serotonin Reuptake Inhibitors, Placebo - Doctor's Guide, 5/10/01
- FDA Approves Extended Use Of Effexor (Venlaxafine HCl) For Treatment Of Depression - Doctor's Guide, 5/9/01
- Bupropion and Nefazodone Cause Less Sexual Dysfunction Than Other New Generation Antidepressants - Doctor's Guide, 5/8/01
- Venlafaxine Superior To Selective Serotonin Reuptake Inhibitors In Treating Major Depressive Disorder - Doctor's Guide, 5/8/01 -
"43 percent to 45 percent of patients on all venlafaxine dosages achieved
remission, a rate significantly higher than those for the SSRIs (35 percent) or placebo (25 percent)."
- Depression Remission Better With Venlafaxine Than Selective Serotonin Uptake Inhibitors - Doctor's Guide, 3/1/01 -
"Remission rates among depressed patients treated
with venlafaxine are significantly higher than among patients treated with selective serotonin reuptake inhibitors."
- Anti-depressant (Effexor®/venlafaxine) counters hot flashes from menopause, chemotherapy - CNN, 12/15/00
- Antidepressant Effexor XR (Venlafaxine) Given FDA Approval For Generalized Anxiety Disorder - Doctor's Guide, 7/17/00
- Anxiously Awaited News: Antidepressant Effectively Relieves Symptoms of Anxiety Disorder - WebMD, 6/21/00
- Venlafaxine Extended Release Effective And Safe For Generalized Anxiety Disorder - Doctor's Guide, 6/20/00
- Venlafaxine Has Role In Painful Diabetic Neuropathy - Doctor's Guide, 6/11/00
- Anti-Depressant Effective Treatment For Hot Flashes - Intelihealth, 5/23/00
- Newer Depression Drug (Effexor) Relieves Hot Flashes - WebMD, 5/22/00
- Long-Term Effectiveness of Effexor XR (Venlafaxine) Confirmed in Generalized Anxiety Disorder - Doctor's Guide, 5/16/00
- Effexor More Effective Than Prozac In Achieving Remission In Depression - Doctor's Guide, 2/10/00
- Venlafaxine Relieves Anxiety Symptoms - Doctor's Guide, 9/23/99
- Antidepressant Venlafaxine Alleviates Hot Flashes in Men - Doctor's Guide, 9/7/99
- Effexor XR Produces Significant Relief From Depression In First Week of Treatment - Doctor's Guide, 5/19/99
- Effexor Produces Superior Remission Rates To SSRIs - Doctor's Guide, 5/19/99
- Effexor XR Effective In Treating Symptoms Of Generalised Anxiety Disorder - Doctor's Guide, 3/26/99
- Effexor XR Approved In The U.S. For Anxiety - Doctor's Guide, 3/12/99
- Effexor Provides Effective Relief Of Anxiety Symptoms - Doctor's Guide, 7/15/98
- Effexor XR Produces Significantly Higher Depression Remission Rates Than Prozac - Doctor's Guide, 6/2/98
- New Formula Offers Treatment For People Who Suffer From Depression - Doctor's Guide, 10/20/97
- Antidepressant Venlafaxine Alleviates Hot Flashes in Men - Doctor's Guide, 9/7/97
Abstracts:
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A randomized, single-blind, comparison of venlafaxine with paroxetine in
elderly patients suffering from resistant depression - Int Clin
Psychopharmacol. 2007 Nov;22(6):371-5 - "Venlafaxine
was significantly superior to paroxetine on Clinical Global Impression Scale
and Hamilton Rating Scale for Depression measures"
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Which antidepressants have demonstrated superior efficacy? A review of the
evidence - Int Clin Psychopharmacol. 2007 Nov;22(6):323-329 -
"Criteria were defined to judge the strength of
evidence. Two pivotal studies in moderate-to-severe major depressive
disorder that demonstrate superiority on the primary efficacy measure, or
alternatively one pivotal study supported by consistent results from
meta-analyses, was considered to constitute evidence for definite
superiority. Three antidepressants met these criteria: clomipramine,
venlafaxine, and escitalopram. Three antidepressants were found to have
probable superiority: milnacipran, duloxetine, and mirtazapine. Only
escitalopram was found to have definite superiority in the treatment of
severe depression; probable superiority was identified for venlafaxine and
possible superiority for milnacipran and clomipra"
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A randomized, double-blind comparison of duloxetine and venlafaxine in the
treatment of patients with major depressive disorder - J Psychiatr Res.
2007 Apr 17 - "were no significant
differences between duloxetine 60mg/day and venlafaxine 150mg/day as
measured by GBR assessment at the end of 6 weeks (-1.418 vs. -1.079,
P=0.217) or 12 weeks ... Nausea was the most common treatment-emergent
adverse event (TEAE) for both drugs, and was significantly higher with
duloxetine 60mg/day compared to venlafaxine 150mg/day during the first 6
weeks of treatment"
-
Escitalopram versus venlafaxine XR in the treatment of
depression - Int Clin Psychopharmacol. 2006
Sep;21(5):297-309 - "treatment with
20 mg/day escitalopram resulted in a statistically significantly (P<0.05)
higher remission rate at week 8 (47%) than treatment with venlafaxine XR
(29%) ... The relative benefit of escitalopram versus venlafaxine XR was
1.46, indicating that a patient was more likely to benefit from treatment
with escitalopram. The proportions of patients who withdrew owing to adverse
events were 7.5% in the escitalopram group and 11.2% in the venlafaxine XR
group" - See
Escitalopram 20mg (Generic Equivalent of Lexapro 20mg)
- OffshoreRx.com.
-
A comparative study of the efficacy of long-term treatment with escitalopram
and paroxetine in severely depressed patients - Curr Med Res Opin. 2006
Jul;22(7):1331-41 - "Escitalopram is
significantly more effective than paroxetine in the long-term treatment of
severely depressed patients"
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