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Home > Health Conditions > Breast Cancer > Arimidex

Arimidex (anastrozole) - 9/00

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Aromatization (in males):

  • Anastrozole (Arimidex) - anabolic-androgenic-steroids.com - "Anastrozole (Arimidex) is the aromatase inhibitor of choice" - see aromatization
  • Middle-Aged Men Can Blame Estrogen, Too - NYTimes.com, 9/11/13 - "Estrogen, the female sex hormone, turns out to play a much bigger role in men’s bodies than previously thought, and falling levels contribute to their expanding waistlines just as they do in women’s" - [WebMD] [Abstract] - Note:  Here's the study they cite but something isn't making sense.  It says "the percentage of body fat increased in groups receiving placebo or 1.25 g or 2.5 g of testosterone daily without anastrozole".  Anastrozole increases testosterone and decreases estrogen yet they're saying that body fat increased without the anastrozole implying that body fat decreased with the anastrozole (more testosterone, less estrogen).  See my aromatization page.  Personally I feel that this study is doing to way too many things that affect the endocrine system that makes the outcome suspect.  It's disturbing how the media is taking off with it like it's written in stone.  For example, how do they know that suppressing all those hormones at the beginning then artificially replacing some didn't also alter others such as insulin, cortisol, the thyroid hormones, etc. which might affect fat?  Blaming it on estrogen seems like a long shot.
    • Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men - NEJM, 9/10/12 - "We provided 198 healthy men 20 to 50 years of age with goserelin acetate (to suppress endogenous testosterone and estradiol) and randomly assigned them to receive a placebo gel or 1.25 g, 2.5 g, 5 g, or 10 g of testosterone gel daily for 16 weeks. Another 202 healthy men received goserelin acetate, placebo gel or testosterone gel, and anastrozole (to suppress the conversion of testosterone to estradiol) ... The percentage of body fat increased in groups receiving placebo or 1.25 g or 2.5 g of testosterone daily without anastrozole (mean testosterone level, 44+/-13 ng per deciliter, 191+/-78 ng per deciliter, and 337+/-173 ng per deciliter, respectively). Lean mass and thigh-muscle area decreased in men receiving placebo and in those receiving 1.25 g of testosterone daily without anastrozole ... The amount of testosterone required to maintain lean mass, fat mass, strength, and sexual function varied widely in men. Androgen deficiency accounted for decreases in lean mass, muscle size, and strength; estrogen deficiency primarily accounted for increases in body fat; and both contributed to the decline in sexual function"
  • Reducing the side effects of treatment for prostate cancer - Science Daily, 8/24/12 - "tamoxifen reduced the risk of both gynecomastia and breast pain at 3, 6, 9, and 12 months of treatment compared to men who received no treatment. Overall, treatment with tamoxifen was more successful in reducing breast symptoms than treatment with an aromatase inhibitor (anastrazole) or radiotherapy" - Note:  They left out Femara (letrozole).
  • Aromatase Inhibition Offers Little Benefit, Possible Harm to Men With Lo... - Medscape, 12/22/09 - "The inescapable conclusion from these data is that the 50% increase in testosterone levels was trumped by the much more modest 20% reduction in estradiol levels, leading to negative skeletal effects of anastrozole therapy in aging men" - Note:  I'm not sure that thought this though thoroughly.  Mortally in men is best when estrogen is around 25pg/mL.  I suspect that most have higher estrogen than that.  See:

    • High, Low Estradiol Levels and Mortality in Men With Systolic HF - Medscape, 5/19/09 - "Both low and high serum levels of estradiol, compared with mid-range levels, are significantly and independently associated with increased all-cause mortality in men with chronic systolic heart failure"
      Serum Estradiol Concentration Quintiles as Predictors of All-Cause Mortality in Men (With Quintile 3 as the Reference Group)
      Parameter Quintile 1 Quintile 2 Quintile 3 Quintile 4 Quintile 5
      Estradiol concentration (pg/mL) <12.903 12.90–21.79 21.80–30.11 30.12–37.39 >37.40
      3-y survival* (%) 44.6 65.8 82.4 79.0 63.6
      Quintile as mortality predictor,* HR (95% CI) vs quintile 3 4.17 (2.33–7.45) 2.15 (1.16–3.99) -- 1.22 (0.64–2.31) 2.33 (1.30–4.18)
      HR= hazard ratio
  • Ibandronate Can Prevent Anastrozole-Induced Bone Loss - Medscape, 6/6/07
  • Drug Combination May Slow Male Breast Cancer Growth - Science Daily, 7/7/06
  • Testosterone Deficiency & Depression, Does DHEA Raise the Levels of Bioavailable Testosterone in Men? - Life Extension Magazine, 8/02 - "Some men on testosterone drug replacement therapy develop dangerously high estrogen levels. Estrogen can be suppressed by taking an aromatase-inhibiting drug like Arimidex (0.5 mg twice a week) or using a supplement like Super Mira Forte (six capsules daily)"
  • Male Hormone Modulation Therapy - Life Extension Magazine - "If all of the above fail to increase free testosterone and lower excess estradiol, then ask your doctor to prescribe the potent aromatase inhibiting drug Arimidex (anastrozole) in the very low dose of one-half (0.5 mg) mg, twice a week"
  • Estrogen suppression in males: metabolic effects - J Clin Endocrinol Metab. 2001 Apr;86(4):1836-8 - "First, a dose-response study of 12 males (mean age, 16.1 +/- 0.3 yr) was conducted, and blood withdrawn at baseline and after 10 days of oral Arimidex given as two different doses (either 0.5 or 1 mg) in random order with a 14-day washout in between. A sensitive estradiol (E2) assay showed an approximately 50% decrease in E2 concentrations with either of the two doses ... There was a 58% increase in serum T"

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