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Anti-aging Research > Acetyl-l-carnitine.
Acetyl-L-Carnitine
Specific Recommendations:
News & Research:
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Acetyl-L-Carnitine
- Vitacost Health Library
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Depression Protocol - Life Extension Foundation
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L-Acetylcarnitine
Curbs ADHD Associated With Fragile X Syndrome - Medscape, 3/12/08 -
"L-acetylcarnitine (LAC) may be considered an
alternative to stimulants for the treatment of attention deficit
hyperactivity disorder (ADHD) in children with fragile X syndrome, based on
results of a double-blind, placebo-controlled study"
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Lipoic acid and carnitine combo show diabetes potential - Nutra USA,
2/18/08 - [Abstract]
- "the combination of LA and LCAR increased the
mass, oxygen consumption, mitochondrial DNA expression, and fatty acid
oxidation in the fat cells ... However, the treatments with LA or ALC alone
at the same concentrations showed little effect on mitochondrial function
and biogenesis ... Lipoic acid and acetyl-L-carnitine have become very hot
after our reports on the complementary effects on improving memory and
ambulatory activity in old rats"
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Complementary and
Integrative Approaches to Dementia - Medscape, 7/5/05 -
"There have been several controlled
clinical trials suggesting that ALc slows the progression of AD"
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Jarrow Formulas’, Inc. Introduces ALCA 500(TM) (Acetyl-L-Carnitine Arginate
Dihydrochloride) - NPI Center, 3/8/05 -
"Acetyl-l-carnitine arginate (ALCA)
represents an advancement in the carnitine and arginine fields as this new
dietary supplement offers potential benefits in affecting levels of nitric
oxide over and above the traditional benefits of carnitine" - See
Jarrow Acetyl L Carnitine Arginate
 .
- Common Nutrient May Ease Diabetic Pain - WebMD,
1/6/05 - "1,000 milligrams three times a day of acetyl-L-carnitine was effective in
relieving pain caused by nerve damage associated with the condition"
- Supplemental Carnitine May Be Helpful in Diabetic Neuropathy
- Medscape, 1/3/05 - "Pain as the most bothersome symptom significantly improved with ALC"
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New uses for carnitine - Functional Foods and Nutraceuticals, 11/04 -
"Because L-carnitine is central to the
formation of energy from fat, the heart is therefore dependent on
L-carnitine for most of its energy production ... L-Carnipure carries
long-chain fatty acids into the mitochondria where they are oxidised for
energy. Its ability to generate energy from fat makes carnitine useful as
part of a weight management program ... L-carnitine plus its metabolite,
acetyl-L-carnitine, can treat symptoms of male ageing, including sexual
dysfunction, depressed mood and fatigue"
- Carnitine Improves Symptoms of Male Aging -
Medscape, 4/14/04 -
"Carnitine
is more active than testosterone for improving symptoms of male aging such
as sexual dysfunction, depressed mood, and fatigue ... In this trial, 120
patients were randomized to receive testosterone undecanoate 160 mg/day,
propionyl-L-carnitine 2 g/day plus acetyl-L-carnitine 2 g/day, or placebo
for six months" - [Abstract]
- See
iHerb
or
Vitacost
acetyl-l-carnitine products and propionyl-l-carnitine at
iHerb.
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Do Anti-aging Supplements Really Work? - Life Extension Magazine, 6/02 -
"The National Academy of Sciences has published three new reports showing
that aging may be partially reversible with currently available supplements"
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The Wizard is Oz - Life Extension Magazine, 11/01 -
"Best-selling author and nutritional guru to the rich and famous, Oz Garcia
is singing the praises of the Life Extension Foundation and its products in
his newest book,
The
Healthy High Tech Body, published in September 2001 ... Supplements at
the top of Garcia's list of recommendations ...
DHA ... NADH ...
Alpah
Lipoic Acid
... Acetyl-L-Carnitine ... An expanded list of his recommendations includes
lycopene, gamma tocopherol,
vinpocetine, SAMe,
folic acid,
carnosine, glutathione, DMAE,
Huperzine A, probiotics,
MSM, secretagogues,
arginine pyroglutamate,
IP-6, bioflavonoid formulas and
grape skin/seed extracts"
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Sustain the Brain - Nutrition Science News, 2/01 -
"By enhancing membrane stability, energy production, and neurotransmission,
ALC may improve mental function. In addition, it may also have
anti-inflammatory effects that reduce free radical generation. . . ALC's
ability to bind cortisol and increase nerve
growth factor production within the hippocampal region may explain its
positive effects on neurons."
- Sperm Booster? - WebMD, 1/1/01
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Can L-carnitine help reverse Alzheimer's disease? - Nutrition Science
News, 8/00
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The Anti-Aging Effects of Acetyl-L-Carnitine - Life Extension Magazine,
5/00 - "When acetyl-L-carnitine was
administered, their heart rates became almost completely restored to the
metabolic function level of young control rats . . . acetyl-L-carnitine is
critical to youthful cellular function in the brain, heart, liver,
peripheral nerve and immune system. Supplementation with
acetyl-L-carnitine becomes an even greater consideration when we realize the
potential antiaging effects this amino acid may produce when taken in
combination with coQ10 and
alpha lipoic acid"
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Staying Young Forever, Putting new research findings into practice -
Life Extension Foundation, 12/99 - "acetyl l-carnitine significantly reversed age-associated mitochondrial
decay. It increased cellular respiration, membrane potential and cardiolipin
levels"
- Lower AGE with Acetyl L-Carnitine - Life
Enhancement Magazine, 8/99 - "Diabetics and others who become susceptible to high levels of glucose in
blood serum as they age suffer from the formation of deleterious hybrid
protein-sugar complexes known as advanced glycation end products (AGE) ...
ALC decreased the glycation by 42%"
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Anti-Cortisols May Offer New Hope For Retinitis Pigmentosa - Doctor's
Guide, 11/17/97 - "According to Sapse, RP can be treated initially with a cocktail of anti-cortisol
nutritional compounds including vitamin A, zinc, ginkgo biloba and
acetyl-L-carnitine . . ."
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Top Ten
Life Extension Drugs - Life Extension Magazine, 9/95
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Acetyl-L-Carnitine Supplements Slow Progression of Alzheimer's Disease
-The Nutrition Reporter, '95
Abstracts:
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R-alpha-Lipoic acid and acetyl-L: -carnitine complementarily promote
mitochondrial biogenesis in murine 3T3-L1 adipocytes - Diabetologia.
2008 Jan;51(1):165-74 - "Treatments with the
combination of LA and ALC at concentrations of 0.1, 1 and 10 mumol/l for 24
h significantly increased mitochondrial mass, expression of mitochondrial
DNA, mitochondrial complexes, oxygen consumption and fatty acid oxidation in
3T3L1 adipocytes. These changes were accompanied by an increase in
expression of Pparg, Ppara and Cpt1a mRNA, as well as increased expression
of peroxisome proliferator-activated receptor (PPAR) gamma coactivator 1
alpha (Ppargc1a), mitochondrial transcription factor A (Tfam) and nuclear
respiratory factors 1 and 2 (Nrf1 and Nrf2). However, the treatments with LA
or ALC alone at the same concentrations showed little effect on
mitochondrial function and biogenesis" - See
Doctor's Best, Best Stabilized R-Lipoic Acid Na-RALA
at iHerb
and
Doctor's Best acetyl-l-carnitine at iHerb.
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Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for
male infertility: a systematic review - Asia Pac J Clin Nutr. 2007;16
Suppl:383-90 - "the administration
of LC and/or LAC may be effective in improving pregnancy rate and sperm
kinetic features in patients affected by male infertility"
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Acetyl-L-Carnitine Improves Pain, Nerve Regeneration, and
Vibratory Perception in Patients With Chronic Diabetic Neuropathy: An
analysis of two randomized placebo-controlled trials
- Diabetes Care. 2005 Jan;28(1):89-94 -
"ALC treatment
is efficacious in alleviating symptoms, particularly pain, and improves
nerve fiber regeneration and vibration perception in patients with
established diabetic neuropathy"
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Carnitine versus androgen administration in the treatment of
sexual dysfunction, depressed mood, and fatigue associated with male aging
- Urology. 2004 Apr;63(4):641-6 - "Carnitines proved significantly more active than testosterone in improving
nocturnal penile tumescence and International Index of Erectile Function
score. Testosterone significantly increased the prostate volume and free and
total testosterone levels and significantly lowered serum luteinizing
hormone; carnitines did not"
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Memory loss in old rats is associated with brain
mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding
acetyl-L-carnitine and/or R-alpha -lipoic acid
- Proc Natl Acad Sci U S A 2002 Feb 19;99(4):2356-2361 -
"Electron microscopic studies in the hippocampus showed that
ALCAR and/or LA reversed age-associated mitochondrial structural decay"
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Mitochondrial decay in aging. Reversal through supplementation of
acetyl-L-carnitine and N-tert-butyl-alpha-phenyl-nitrone - Ann N Y Acad
Sci. 1998 Nov 20;854:214-23 - "ALCAR supplementation (1 month) resulted in significant increases in
cellular respiration, mitochondrial membrane potential, and cardiolipin
values"
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Acetyl L-carnitine slows decline in younger patients with
Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled
study using the trilinear approach - Int
Psychogeriatr. 1998 Jun;10(2):193-203 - "ALC slows the progression of Alzheimer's disease in younger
subjects, and the use of the trilinear approach to estimate the average rate
of change may prove valuable in pharmacological trials"
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Acetyl-L-carnitine in Alzheimer disease: a short-term study
on CSF neurotransmitters and neuropeptides -
Alzheimer Dis Assoc Disord 1995 Fall;9(3):128-31 - "beta-endorphins significantly decreased after treatment;
plasma cortisol levels matched this reduction. Since both CSF
beta-endorphins and plasma cortisol decreased, one possible explanation is
that ALCAR reduced the AD-dependent hypothalamic-pituitary-adrenocortical
(HPA) axis hyperactivity"
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