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Home > Anti-aging Research > Antidepressants > Tianeptine


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  • Sexual Dysfunction Common But Conservatively Treated In Depressed Patients - Doctor's Guide, 5/26/03 - "Sexual dysfunction was observed in 35% of those spontaneously reporting problems and in 69% of those with problems identified by physician questioning. Of patients treated with antidepressants, 71% reported sexual dysfunction compared to 65% in untreated patients. The researchers also found that treatment with tianeptine was associated with a lower incidence of sexual dysfunction than was treatment with tricyclic antidepressant or serotonin reuptake inhibitors" - Interesting because depression is associated with high cortisol and tianeptine has been shown to counter the effects of cortisol.  That supports the theory of cortisol being the cause. - Ben
  • Major Depression: Tianeptine At Least Halves Relapse And Recurrence Rates - Doctor's Guide, 3/29/01 - "A smaller proportion of the tianeptine group experienced either relapses or recurrences compared to placebo (16 and 36 percent, respectively) ... events related to treatment were rare and mild in both arms of the study ... The rates of relapse and recurrence decreased between two- and three-fold among tianeptine users compared to placebo. However, the treatments were equally well accepted by the two groups" - note: tianeptine is believed to inhibit cortisol - Ben
  • Findings Show Cortisol's Major Role in AIDS and Other Diseases - Doctor's Guide, 6/21/96 - "Researchers have already started to explore the therapeutic benefits of such an approach through the use of anti-cortisol drugs, such as RU-486, DHEA, Ketaconazole, Anticort and Tianeptine"

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