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Anti-aging Research > Statins
Note: Red yeast rice is a
non-prescription statin but check with your doctor first. See
red yeast rice products.
CoQ10 and L-carnitine
for Statin Myalgia? - Medscape, 1/4/13 - "In
summary, it has been proposed that CoQ10 can help to treat statin myalgia. While
this is not conclusive, there are two randomized controlled trials showing
significant improvements in the severity of muscle pain with the use of CoQ10 in
patients treated with statins. Thus, it is not unreasonable to supplement a
patient who is experiencing muscle pains on a statin with CoQ10. While there are
no clinical trials showing improvements in muscle pain with the use of
l-carnitine, patients who experience statin myalgia frequently have carnitine
abnormalities. It is too soon to recommend l-carnitine for statin myalgia, but
future trials should test this supplement to see if it has any place for this
adverse effect. Other common alternatives for treating statin myalgias are
supplementation with vitamin D or vitamin B12, especially in the setting of
suboptimal serum levels"
- See Jarrow Formulas, Ubiquinol QH-Absorb, 100 mg, 60 Softgels at iHerb, Jarrow Formulas, GPLC, Glyco Carn, 500 mg, 60 Veggie Caps at iHerb
acetyl-l-carnitine products at iHerb.
Cholesterol medicine affects energy production in muscles - Science Daily,
1/3/13 - "A well-known side effect of statin therapy is
muscle pain. Up to 75 per cent of the physically active patients undergoing
treatment for high cholesterol experience pain. This may keep people away from
either taking their medicine or from taking exercise -- both of which are bad
choices ... Scientists also showed that the patients examined who were being
treated with statins had low levels of the key protein Q10. Q10 depletion and
ensuing lower energy production in the muscles could be the biological cause of
the muscle pain that is a problem for many patients" - See Jarrow Formulas, Ubiquinol QH-Absorb, 100 mg, 60 Softgels at iHerb.
n-3 fatty acids on major cardiovascular events in statin users and non-users
with a history of myocardial infarction - Eur Heart J. 2012 Feb 1 -
"In statin users, an additional amount of n-3 fatty
acids did not reduce cardiovascular events [HR(adj) 1.02; 95% confidence
interval (CI): 0.80, 1.31; P = 0.88]. In statin non-users, however, only 9% of
those who received EPA-DHA plus ALA experienced an event compared with 18% in
the placebo group ... In patients with a history of MI who are not treated with
statins, low-dose supplementation with n-3 fatty acids may reduce major
cardiovascular events. This study suggests that statin treatment modifies the
effects of n-3 fatty acids on the incidence of major cardiovascular events" - See
Mega Twin EPA at iHerb
Jarrow Max DHA at iHerb.
bacteria may affect whether a statin drug lowers cholesterol - Science
Daily, 10/13/11 - "Among the group who had a strong response to the drug, three
bile acids appeared to play a role. The bile acids are produced by certain gut
bacteria, which are increasingly understood as factories for chemicals that can
contribute to a state of health. Among the people who responded poorly to the
statin, five different bile acids were commonly evident ... new strategies could
be developed to manipulate the gut microbiome using probiotics to spur different
gut bacteria, which could then give the drugs a boost" - See
probiotic products at iHerb.
reduce deaths from infection and respiratory illness, data eight years on from
trial suggests - Science Daily, 8/28/11 - "In the
lipid-lowering arm of the trial, over 10,000 patients in the UK, Ireland and
Scandinavia with high blood pressure were randomly allocated either atorvastatin
or placebo between 1998 and 2000. In 2003, the trial was stopped early because
the statin proved to be highly beneficial in preventing heart attacks and
strokes. Since then, most participants from both groups have been taking statins
... The new analysis looked at the number and cause of deaths among the 4,605
participants in the ASCOT trial who are based in the UK. After 11 years'
follow-up, overall mortality is 14 per cent lower in the group originally
assigned atorvastatin, due largely to fewer deaths from infection and
effect of lycopene on serum cholesterol and blood pressure: Meta-analyses of
intervention trials - Maturitas. 2010 Dec 14 - "Lycopene, a carotenoid found
in tomatoes ... Meta-analysis of the effect of lycopene on systolic blood
pressure of all trials suggested a significant blood pressure reducing effect
(mean systolic blood pressure change±SE: -5.60±5.26mm Hg, p=0.04) ... Our
meta-analysis suggests that lycopene taken in doses ≥25mg daily is effective in
reducing LDL cholesterol by about 10% which is comparable to the effect of low
doses of statins in patient with slightly elevated cholesterol levels" - See
Jarrow Lyco-Sorb (contains Lyco-O-Mato) at iHerb.
Red Yeast Rice Comparable to Pravastatin for Statin-Intolerant Patients
- Medscape, 1/21/10 - "After 12 weeks of treatment,
red yeast rice reduced LDL-cholesterol levels 30% from baseline, from 181
mg/dL to 126 mg/dL, while pravastatin reduced LDL-cholesterol levels 27%, a
nonstatistical difference between treatments. Similarly, there were no
significant differences observed in changes in total cholesterol,
triglycerides, or HDL-cholesterol levels ... Regarding the primary end
point, the incidence of treatment discontinuation because of myalgia, both
red yeast rice and pravastatin were equivalent. In the red-yeast-rice arm,
one patient of 21 (5%) withdrew because of muscle pain, while two patients
of 22 (9%) withdrew in the pravastatin arm. Also, there were no reported
differences in the mean pain severity scores with the two treatments"
red yeast rice products at iHerb.
B niacin offers no extra benefit to statin therapy in seniors already diagnosed
with coronary artery disease, study suggests - Science Daily, 11/18/09 -
"This does not mean that niacin therapy may not have
other cardiovascular benefits, but any such benefits are independent of reducing
the amount of plaque buildup and patients should be aware of that ... Lima
cautions that an ongoing national study of the long-term vascular benefits of
dual therapy and whether extended-release niacin,
also known as nicotinic acid, lowers death rates from heart disease should
provide more definitive data" - Note: The article implies that
prescription Niaspan works better than immediate release niacin. See
which implies the opposite. The prescription might have less flush but I
couldn't tell the difference. Like I've said in the past, the flush gets
less the longer you use it and is practically non-existent after you taken it
for several months if you take it with food. Also, the slow release may
produce liver damages. See:
Endothelial Dysfunction in Statin-Treated Type 2 Diabetics - Medscape,
5/29/09 - "Study subjects were randomized to receive
either 200 mg/day of oral CoQ10 or placebo for 12 weeks ... Our absolute
improvement in FMD of 1% with CoQ10 supplementation may potentially
translate to a 10-25% reduction in residual cardiovascular risk in these
patients" - See
coenzyme Q10 products at iHerb.
Taking Statins? Five Ways
to Boost Your Energy - ABC News, 4/14/09 - "It's
a cruel irony that if statins make patients more lethargic, it could impair
their ability to exercise or make dietary changes that would help them
address their high cholesterol ... some studies have found that patients'
energy levels increased while using CoQ10 and statins together ... Try
pomegranate juice or a small chunk of dark chocolate, both of which have
beneficial antioxidants ... Skimping on sleep has been found to increase
calcium deposit build-up in your arteries" - See
Jarrow Ubiquinol at iHerb.
Statins' Adverse Effects Documented - Science Daily, 1/29/09 -
"Coenzyme Q10 ("Q10") is a compound central to the
process of making energy within mitochondria and quenching free radicals.
However, statins lower Q10 levels because they work by blocking the pathway
involved in cholesterol production – the same pathway by which Q10 is
produced. Statins also reduce the blood cholesterol that transports Q10 and
other fat-soluble antioxidants ... "The loss of Q10 leads to loss of cell
energy and increased free radicals which, in turn, can further damage
mitochondrial DNA," said Golomb, who explained that loss of Q10 may lead to
a greater likelihood of symptoms arising from statins in patients with
existing mitochondrial damage – since these people especially rely on ample
Q10 to help bypass this damage" - My favorite is
QH-Absorb by Jarrow.
Fish Oil, Red Yeast Rice Cut Cholesterol - WebMD, 7/23/08 -
"We followed them for a three-month period ... The
LDL declined 42% in the supplement group and 39% in the Zocor group ... The
supplement group also lost an average of 10 pounds in 12 weeks, but there
was no significant weight loss in the medication group. Triglyceride levels,
while on average normal in both groups at the start, decreased by 29% in the
supplement group but just 9.3% in the medication group -- a significant
difference" - See
red yeast rice products at iHerb
Mega Twin EPA at iHerb.
Lowering Blood Cholesterol With Fish Oil And Red Yeast Rice Instead Of
Statins - Science Daily, 7/8/08 - "The
alternative treatment group participants received daily fish oil and red
yeast rice supplements ... The statin group participants received 40
milligrams (mg) of Zocor (simvastatin) daily ... The researchers noted that
there was a reduction in LDL cholesterol levels in both groups. The
alternative treatment group experienced a 42.4 percent reduction, and the
statin group experienced a 39.6 percent reduction. Members of the
alternative therapy group also had a substantial reduction in triglycerides,
another form of fat found in the blood, and lost more weight" - See
red yeast rice products at iHerb
Mega Twin EPA at iHerb.
Lycopene as effective as statins for artery health: rabbit study - Nutra
USA, 7/3/08 - "The results of our experiment in the
high-fat diet rabbit model showed that lycopene and fluvastatin lowered
serum levels of total cholesterol and LDL-cholesterol, improved lipid
metabolism, and reduced the amount of triacylglycerols ... Lycopene
intervention reduced the increase in ox-LDL levels in rabbits on the
high-fat diet, whereas fluvastatin did not show such an effect. The cause of
this difference is at present not known, although the result speaks in
favour of lycopene ... These findings provide a theoretical rationale for
the use of lycopene as a preventive in atherosclerosis" - [Abstract]
Jarrow Lyco-Sorb (contains Lyco-O-Mato) at iHerb.
Comparison of lycopene and fluvastatin effects on atherosclerosis induced by
a high-fat diet in rabbits - Nutrition. 2008 Jun 26 -
"Compared with the control, levels of total
cholesterol, total triacylglycerol, low-density lipoprotein cholesterol,
malonaldehyde, oxidized low-density lipoprotein, and interleukin-1 were
increased and total antioxidant capacity and nitric oxide were decreased in
the animals with a high-fat diet (P < 0.05). Intragastric administration of
lycopene counteracted the change in these parameters (P < 0.05). In this
case, the data showed that lycopene in the used dose was better than the
fluvastatin intervention. Morphologic analysis revealed that lycopene and
fluvastatin markedly reduced the formation of atherosclerotic plaques in the
aorta compared with the situation in rabbits on a high-fat diet alone ...
Lycopene, like fluvastatin, significantly attenuated atherogenesis in
rabbits fed a high-fat diet" - See
Jarrow Lyco-Sorb (contains Lyco-O-Mato) at iHerb.
Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and
liver and muscle enzyme levels in hypercholesterolemic patients treated with
atorvastatin: A randomized double-blind study - Atherosclerosis. 2007
Aug 4 - "All patients showed definite
reductions of plasma CoQ10 levels in the placebo group, by 42%. All patients
supplemented with CoQ10 showed striking increases in plasma CoQ10 by 127%.
In conclusion atorvastatin definitely decreased plasma CoQ10 levels and
supplementation with CoQ10 increased their levels"
Effect of coenzyme q10 on myopathic symptoms in patients treated with
statins - Am J Cardiol. 2007 May 15;99(10):1409-12 -
"coenzyme Q10 supplementation may
decrease muscle pain associated with statin treatment. Thus, coenzyme Q10
supplementation may offer an alternative to stopping treatment with these
vital drugs" - See
coenzyme Q10 products at iHerb.
Combining Agents Leads to Safe Treatment of Lipid Abnormalities -
Physician's Weekly, 5/7/07 -
"Combining the use of statins and niacin should be encouraged because it
appears to safely treat multiple lipid abnormalities in appropriate
Niacin Extended-Release Tablets Combined With Low/Moderate Dosed Statin
Achieves Better Total Lipid Control Versus Higher Dose Statin Monotherapy or
Simvastatin and Ezetimibe - Doctor's Guide, 6/22/06 -
"patients given Niaspan in
combination with a low to moderate dose of Lipitor or Crestor achieved
equivalent reduction in LDL-C (51-58%), 1.2 to 1.9-fold greater decreases in
triglycerides and 2.5 to 3.5 fold greater increases in HDL-C, than patients
who received high-dose Crestor or Zocor/Zetia" - See
niacin products. My favorite is
Twinlab niacin 1000mg at iHerb.
Coenzyme Q10 Lessens Muscle-Related Side Effects in Patients on Statins
- Doctor's Guide, 3/7/05 - "Patients
with significant myopathy who are taking statin therapy have a significant
decrease in myopathic pain after 30 days of supplementation with coenzyme
Q10" - See
coenzyme Q10 products.
- Diet Can Lower Bad Cholesterol Like Statin Drug -
WebMD, 2/8/05 - "Load up on fiber
and vegetables: They lower cholesterol almost as much as
cholesterol-lowering statin drugs ... Here's your shopping list:
Cholesterol-lowering margarines containing plant fats such as "Benecol"
or "Take Control", soy proteins and soluble fibers like oats, barley,
psyllium, plus all kinds of vegetables, including eggplant and okra"
Atorvastatin Decreases the Coenzyme Q10 Level in the Blood of Patients at
Risk for Cardiovascular Disease and Stroke - Arch Neurol.
2004;61:889-892 - "Even brief exposure to atorvastatin
causes a marked decrease in blood CoQ10
concentration. Widespread inhibition of CoQ10 synthesis could explain the
most commonly reported adverse effects of statins, especially exercise
intolerance, myalgia, and myoglobinuria" - See
coenzyme Q10 products.
- Are Statins
the New Wonder Drugs? - Dr. Weil, 6/21/04 -
"For moderately elevated cholesterol, I recommend non-prescription
red rice yeast, a natural source of statins
with fewer side effects" - See
red yeast rice products.
Policosonal: Nature's Cholesterol Balancer - Vitamin Research News, 2/04
- "Statin drugs are also known to
cause male impotence" - See
- Diet Can Be as Effective as Statin Therapy in Lowering Cholesterol
- Doctor's Guide, 7/25/03
- Low-Cholesterol Diet as Good as Drugs - WebMD,
7/22/03 - "a vegetarian diet
combining four types of cholesterol-lowering foods works as well as
cholesterol-lowering drugs known as statins ... It had four basic
components: plant sterols in the form of a cholesterol-lowering margarine;
soy proteins; sticky or soluble fibers such as fruits, vegetables, oats, and
legumes; and almonds"
- Policosanol more Effective than Lovastatin for Intermittent Claudication
- New Hope Natural Media, 5/29/03 -
"Those taking policosanol had a 34% increase
in pain-free walking distance, while no change was observed in those taking
lovastatin. Quality of life was also reported as being significantly better
in the policosanol group compared with the lovastatin group. Both treatment
groups had significant reductions in total cholesterol and LDL cholesterol.
However, participants taking policosanol had a significant 32% increase in
HDL cholesterol and a 6% decrease in fibrinogen, while these parameters
remained unchanged in those receiving lovastatin" - See
policosanol products. Claudication
gets my attention because my father has it and if there is a hereditary
factor, I want to prevent it. - Ben
- Ispaghula Husk [psyllium] Nearly As Effective As Simvastatin For
Hyperlipidemia - Doctor's Guide, 12/24/02 -
"One group received 3.5 grams of
ispaghula husk twice a day and the second group
received 20 milligrams of simvastatin each day ... total
cholesterol decreased by 15.8 percent and low-density lipoprotein (LDL)
cholesterol decreased by 22.97 percent among patients taking ispaghula husk
... Triglycerides decreased by 20.89
percent and high-density lipoprotein (HDL)
cholesterol increased by 10.69 percent in these patients ... Among patients
taking simvastatin, total cholesterol decreased by 24.15 percent, LDL
cholesterol decreased by 36.08 percent, triglycerides decreased by 20.47
percent and HDL cholesterol increased by 11.4 percent" - I've got
Drugstore.com psyllium products.
3.5 grams is about one wafer (3.4 grams psyllium/wafer). Plus 24
wafers runs about
for 30 of the 20 mg simvastatin.
Cholesterol Control? - Dr. Weil, 10/1/02 -
"And it contains seven different statins, not just lovastatin. In my
experience, the natural mixture of compounds is less toxic (to the liver and
muscles) than isolated lovastatin ... Other brands of
red rice yeast extract are still available in the U.S., although they
haven’t been clinically proven as was Cholestin, and may not be as
- Fish Oil May Augment Atorvastatin As Treatment For Dyslipidemia In Obese,
Insulin-Resistant Men - Doctor's Guide, 8/7/02 -
"fish oils significantly decreased plasma levels of
triglycerides and very low density lipoprotein-apoB, decreased the very
low density lipoprotein-apoB secretion rate ... combined treatment with
atorvastatin and fish oils decreased very
low density lipoprotein-apoB secretion and increased the fractional
catabolic rate of apoB in each lipoprotein fraction , as well as the percent
conversion of very low density lipoprotein to low density lipoprotein"
- See TwinLab Mega Twin EPA at
Dr. Julian M. Whitaker Petitions FDA to Include CoQ10 Use Recommendation in
All Statin Drug Labeling - Life Extension Magazine, 8/02 -
"On May 23, 2002, Dr. Julian M. Whitaker filed two citizens petitions with
the Food and Drug Administration. The petitions call on the Commissioner of
Food and Drugs to change the labeling of all
inhibitor drugs (the so-called statin drugs), and to issue a Medication
Guide, warning consumers of the need to take coenzyme
Q10 (CoQ10) whenever they take a statin drug"
- Vitamins Help After Heart Transplant - WebMD,
3/28/02 - "The plaque-fighting
benefits of the antioxidant supplements
were even greater than those found using statin medications, which have
already been shown to slow hardening of the arteries after transplants.
Previous research has shown that antioxidants, such as
vitamin C and E, can promote heart health
by reducing blood clots and keeping the blood vessels flexible"
Do Statins Protect
Against Glaucoma? - Medscape, 5/13/13 -
"open-angle glaucoma (OAG) ... used a nationwide healthcare claims database
containing detailed medical records for more than 500,000 patients with
hyperlipidemia to determine whether an association exists between statin use
and the development of OAG ... the risk for OAG decreased 0.3% (adjusted
hazard ratio [HR], 0.997; 95% confidence interval [CI], 0.994-0.999) for
every additional month of statin use. Individuals with hyperlipidemia who
took statins continuously for 2 years had an 8% (adjusted HR, 0.922; 95% CI,
0.870-0.976) lower OAG risk compared with those who received no statin
Cholesterol Drugs Might Boost Kidney Cancer Survival - WebMD, 5/7/13 -
"Over three years, 10 percent of the patients who
took statins died of their cancer, compared with 17 percent of those who did
not take this type of drug ... Last year in a study published in the New
England Journal of Medicine, Danish researchers studied 13 different cancers
and found that in all types, the use of statins was associated with longer
cancer specific survival"
Taking cholesterol-lowering drugs may also reduce the risk of dying from
prostate cancer - Science Daily, 5/2/13 - "After
a mean follow-up of almost eight years, the researchers found that the risk
of death from prostate cancer among statin users was 1 percent as compared
to 5 percent for nonusers"
Statins and Cancer
Mortality: Some Comfort - Medscape, 2/25/13 -
"They found that, overall, no matter what dose of statin patients were
taking, statins reduced cancer mortality by about 15%"
Statins and Colorectal
Cancer - Medscape, 2/18/13 - "In a retrospective
analysis conducted in more than 2500 veterans with a history of colonoscopic
polypectomy for adenomas, Siddiqui et al showed a 49% reduction in the
incidence of recurrent adenomas, and a 29% reduction in the incidence of
advanced adenomas, associated with continuous statin use over 3 to 5 years.
In a subsequent analysis of 231 individuals from the same population,
significantly fewer adenomas, of smaller size, were observed at follow-up
colonoscopy in individuals who had achieved 30% or more reduction in LDL
cholesterol level, compared with those who had not. This suggests that lipid
lowering, rather than statin use per se, may be partly responsible for the
effect of statins on adenoma development and progression. An independent
case-control study of 197 patients, also from a veterans population, found
no association between statin use and adenoma recurrence over a median of
3.4 years. Furthermore, a secondary analysis of data from 3 large
colorectal adenoma chemoprevention trials, with a combined total of 2915
subjects, failed to show any association between statin use and the
recurrence of any adenomas, multiple adenomas, or advanced adenomas. The
prevalence of self-reported statin use was, however, low (8.1%) across the 3
chemoprevention trials, limiting power for the post hoc analysis. Statin
users comprised a much larger proportion (37%) of participants in the
Adenoma Prevention With Celecoxib (APC) trial. However, in a secondary
analysis of APC trial data, Bertagnolli et al found no evidence to
support a chemopreventive effect of statin use over 5 years of follow-up. On
the contrary, statin use of more than 3 years was associated with a 39%
increased risk of adenoma recurrence. Although these data are derived from
an RCT, statin use was self-selected, and the patient population comprised
only high-risk patients with a history of multiple or large adenomas,
limiting the generalizability of the results. Nonetheless, this analysis
represents a large prospective study of statin use and incident adenomas.
Furthermore, assessment of the association between statin use and study end
points was a planned secondary analysis"
and colorectal cancer risk: a longitudinal study - Cancer Causes
Control. 2013 Jan 30 - "After multivariable
adjustment, initiators of statins had a lower incidence rate of CRC as
compared to initiators of glaucoma drugs [hazard ratio (HR) 0.79; 95 % CI
0.69-0.90]. In sex-stratified analyses we observed a protective effect in
men (HR 0.77; 95 % CI 0.67-0.88) but not in women (HR 0.96; 95 % CI
use and reduced cancer-related mortality - N Engl J Med. 2012 Nov 8 -
"Multivariable-adjusted hazard ratios for statin
users, as compared with patients who had never used statins, were 0.85 (95%
confidence interval [CI], 0.83 to 0.87) for death from any cause and 0.85
(95% CI, 0.82 to 0.87) for death from cancer"
Statins may reduce risk of esophageal cancer - Science Daily, 10/22/12 -
"Only 1 in 5 patients with this cancer will still be
alive five years after diagnosis ... The Mayo study combined data from 13
studies that included over 1.1 million patients, of which 9,285 had
esophageal cancer. The analysis found statins lowered cancer risk by nearly
one-third; the longer a patient was on statins, the greater the protective
effect ... When researchers looked specifically at Barrett's esophagus,
patients taking a statin and aspirin reduced their risk of esophageal cancer
by 72 percent"
Use As a Moderator of Metformin Effect on Risk for Prostate Cancer Among
Type 2 Diabetic Patients - Diabetes Care. 2012 Mar 28 -
"Mean follow-up was ∼5 years, and 7.5% had a PCa
diagnosis. Statin use modified the effect of metformin on PCa incidence (P <
0.0001). Metformin was associated with a significantly reduced PCa incidence
among patients on statins (HR 0.69 [95% CI 0.50-0.92]; 17 cases/533
metformin users vs. 135 cases/2,404 sulfonylureas users) and an increased
PCa incidence among patients not on statins (HR 2.15 [1.83-2.52]; 22
cases/175 metformin users vs. 186 cases/1,930 sulfonylureas users). The HR
of PCa incidence for those taking metformin and statins versus those taking
neither medication was 0.32"
Low Levels of LDL
Cholesterol Predate Cancer Cases - Medscape, 3/25/12 -
"there is nothing here to suggest that statins would
Statin Risks Outweighed by Statin Benefits - USA Today, 3/1/12 -
"Clinical trials show that all of these
cholesterol-lowering drugs cut the risk of heart disease by 25% to 30% ...
analyses of controlled trials show that those who cross the threshold into
diabetes had exactly the same benefits of the statin ... As for the memory
loss and confusion, Nissen says it is "rare and completely reversible.""
New Warnings on Cholesterol-Lowering Statins - WebMD, 2/28/12 -
"Memory loss, confusion, high blood sugar, and type
2 diabetes are possible side effects of the popular cholesterol-lowering
drugs known as statins ... Brand name and generic versions of statin drugs
must carry these warnings on their labels"
Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's
Health Initiative - Arch Intern Med. 2012 Jan 9 -
"The WHI recruited 161 808 postmenopausal women aged
50 to 79 years at 40 clinical centers across the United States from 1993 to
1998 with ongoing follow-up ... Statin use at baseline was associated with
an increased risk of DM (hazard ratio [HR], 1.71; 95% CI, 1.61-1.83). This
association remained after adjusting for other potential confounders
(multivariate-adjusted HR, 1.48; 95% CI, 1.38-1.59) and was observed for all
types of statin medications"
Statins linked to higher diabetes risk - USATODAY.com, 1/9/12 -
"Study authors advise patients not to stop taking
their medications without talking to a doctor, because statins' proven power
to prevent heart attacks and strokes outweighs any potential increase in
type 2 diabetes risk. But the results - a nearly 50% increase in diabetes
among longtime statin users - should throw cold water on the idea of
prescribing these drugs to healthy people, which some have recommended as a
way to prevent disease ... In the study, 6.4% of women who didn't use
statins developed diabetes during the eight to nine years of follow-up ...
That rate rose to 9.9% among statin users"
Prescriptions and Breast Cancer Recurrence Risk - Medscape, 12/22/11 -
"It is possible that some past incidence studies did
not observe an association because a high proportion of statin users took
hydrophilic drugs. For instance, Cauley et al. observed a lower risk of
breast cancer among lipophilic statin users, 82% of whom took either
simvastatin or lovastatin (HR = 0.82, 95% CI = 0.70 to 0.97); and Boudreau
et al. observed an inverse association with overall statin use, when
approximately 48% of the study participants were simvastatin or lovastatin
users (odds ratio = 0.7, 95% CI = 0.4 to 1.0). However, Woditschka et
al. observed no association between statin use and breast cancer
incidence in which most users were exposed to the lipophilic drugs
simvastatin and lovastatin (odds ratio = 1.02, 95% CI = 0.97 to 1.08);
and Friis et al. studied statin use and breast cancer incidence in a
Danish population that overlaps with the population analyzed in our study
(so simvastatin is expected to have accounted for a large proportion of the
overall statin exposure) and also observed no association; (relative risk =
1.02, 95% CI = 0.76 to 1.36). Although the apparent discordance between
the statin associations with breast cancer incidence and recurrence may be
explained by inadequate exposure characterization with respect to
solubility, it is also important to realize that factors which prevent
recurrence are not necessarily expected to also prevent incidence"
Study: Statins reduce flu death risk by half - USA Today, 12/14/11 -
"Patients on statins were 41 percent less likely to
die, the study found, even after adjusting for age, the presence of heart,
lung and/or kidney disease, whether or not they had had a flu shot, or
whether or not they had received antiviral medications such as Tamiflu ...
There's no question that these observations are striking in terms of death
from influenza but they can't say why"
of early statin therapy in patients with acute myocardial infarction who
have extremely low low-density lipoprotein cholesterol - J Am Coll
Cardiol. 2011 Oct 11;58(16):1664-71 - "Intensive
lipid-lowering therapy with a target LDL-C value <70 mg/dl is recommended in
patients with very high cardiovascular risk. However, whether to use statin
therapy in patients with baseline LDL-C levels below 70 mg/dl is
controversial ... Statin therapy significantly reduced the risk of the
composite primary endpoint (adjusted hazard ratio [HR]: 0.56; 95% confidence
interval [CI]: 0.34 to 0.89; p = 0.015). Statin therapy reduced the risk of
cardiac death (HR: 0.47; 95% CI: 0.23 to 0.93; p = 0.031) and coronary
revascularization (HR: 0.45, 95% CI: 0.24 to 0.85; p = 0.013). However,
there were no differences in the risk of the composite of all-cause death,
recurrent MI, and repeated percutaneous coronary intervention rate"
Evidence for Lowering LDL to Below 70 - Medscape, 10/4/11 -
"They compared outcomes among 1054 patients with LDL
levels below 70 mg/dL at the time of their MI as to whether they were
discharged on a statin or not ... Results showed that the rate of major
adverse cardiac events at one year was significantly lower in those patients
who were taking a statin, with the benefit mainly driven by the reduction of
cardiac death and coronary revascularization ... Dr Roger Blumenthal (Johns
Hopkins University, Baltimore, MD) suggested the study supported the
pleiotropic effects of statins and the idea that the ideal LDL-C is probably
closer to 50 than to 70 mg/dL ... levels of LDL below 70 are on a par with
those of nonhuman primates who don't develop atherosclerosis, adding that,
like these primates, humans were designed to be vegetarians ... Chimpanzees
don't eat meat; they eat very little fat. They have LDL levels in the range
of 40 to 70, and they don't get atherosclerosis. Maybe we wouldn't get
atherosclerosis either if we had levels this low"
mortality according to lipid-lowering drugs and lipoproteins in a general
population - Curr Med Res Opin. 2011 Sep 7 -
"The beneficial effect of lipid-lowering drugs (LLD) on cardiovascular risk
is established, but long term safety data remain scarce. Our aim was to
assess 10-year risk of cancer mortality according to blood lipoprotein
levels and LLD exposure, in a general population ... There were 3262
participants and 177 deaths were recorded over the 10-year period (78 due to
a cancer). The sample comprised 64% of normolipidaemic, 25% of untreated
dyslipidaemic and 11% of dyslipidaemic subjects treated with LLD (4%
statins, 6% fibrates and 1% other hypolipidaemic drugs). After adjustment
for centre, age, gender, smoking, gamma-glutamyl transpeptidase and mean
corpuscular volume, the hazard ratios (HR) for cancer mortality in subjects
with non-HDL cholesterol <3.5 mmol/L (135 mg/dL) and in those with HDL
cholesterol <0.90 mmol/L (35 mg/dL) were 2.74 (95% confidence interval:
1.66-4.52, p < 0.001) and 2.83 (1.62-4.96, p < 0.001), respectively. The
adjusted HR for cancer mortality was 0.31 (0.11-0.86, p = 0.025) in people
on LLD compared to untreated subjects. Conclusions: In the present study, we
confirm the significant association between low cholesterol and cancer
mortality without finding any harmful signal regarding cancer risk
associated with the use of LLD"
Intake of Cholesterol Is Positively and Use of Cholesterol-Lowering
Medication Is Negatively Associated with Prevalent Age-Related Hearing Loss
- J Nutr. 2011 May 25 - "After multivariable
adjustment, the likelihood of prevalent hearing loss increased from the
lowest (reference) to the highest quartile of dietary cholesterol intake
(P-trend = 0.04). Among persons self-reporting statin use (n = 274), a 48%
reduced odds of prevalent hearing loss was observed after multivariable
adjustment [OR = 0.52 (95% CI = 0.29-0.93)]. Participants in the second and
3rd quartiles of dietary monounsaturated fat intake compared with those in
the first quartile (reference) had a significantly reduced risk of hearing
loss progression 5 y later [multivariable-adjusted OR = 0.39 (95% CI =
0.21-0.71)] and [OR = 0.51 (95% CI = 0.29-0.91)], respectively. Our results
suggest that a diet high in cholesterol could have adverse influences on
hearing, whereas treatment with statins and consumption of monounsaturated
fats may have a beneficial influence"
and Prostate Cancer Diagnosis and Grade in a Veterans Population - J
Natl Cancer Inst. 2011 Apr 15 - "Compared with men
taking an antihypertensive medication, statin users were 31% less likely (HR
= 0.69, 95% CI = 0.52 to 0.90) to be diagnosed with prostate cancer.
Furthermore, statin users were 14% less likely (HR = 0.86, 95% CI = 0.62 to
1.20) to be diagnosed with low-grade prostate cancer and 60% less likely (HR
= 0.40, 95% CI = 0.24 to 0.65) to be diagnosed with high-grade prostate
cancer compared with antihypertensive medication users. Increased levels of
total cholesterol were also associated with both total (HR = 1.02, 95% CI =
1.00 to 1.05) and high-grade (HR = 1.06, 95% CI = 1.02 to 1.10) prostate
cancer incidence but not with low-grade prostate cancer incidence (HR =
1.01, 95% CI = 0.98 to 1.04)"
Statins make radiation more effective at curing prostate cancer, study
suggests - Science Daily, 3/23/11 - "the men
taking statins were less like to relapse than other patients. At five years,
11 percent of men taking statins saw their cancer return compared to 17
percent of patients not taking the medication. At eight years, 17 percent of
men on statins had a relapse compared to 26 percent not taking the drug"
may prevent diabetic-related blindness, study suggests - Science Daily,
2/17/11 - "oral treatment with the drug atorvastatin blocked the formation of
free radicals in the retina, which restored proper levels of nerve growth factor
and preserved neurons in the retina. "It removed the break on the pro-form nerve
growth factor to develop into its mature form," she said. The drug was orally
administered to rats in doses proportional to levels given to human patients
with cardiovascular problems ... In a related study, also in the March edition
of the journal Diabetologia, El-Remessy and her colleagues found that
epicathecin, a component of green tea, also prevented the adverse actions of
proNGF in the retina. It does not affect the maturation of proNGF into NGF,
explained El-Remessy, but regulated a receptor downstream that proNGF uses to
send a signal to kill the neuron. Epicathechin prevents the death by inhibiting
that receptor. "We are still getting the same result, that we are preventing
neuronal death and restoring neuronal function, but just in a different way,"" -
Jarrow Green Tea
extract at iHerb.
Statins Lower Cardiovascular Risk Regardless of Baseline LDL : Abstract and
Introduction - Medscape, 1/21/11 - "In the
placebo-controlled trials, statin recipients had a 41-mg/dL greater decline
in LDL-C and a significant 22% reduction in first major vascular events
(2.8% vs. 3.6% annually). In the high-dose versus low-dose trials, high-dose
patients had a 20-mg/dL greater decline in LDL-C and a significant 15%
reduction in first major vascular events (4.5% vs. 5.3% annually). Relative
risk reductions of about 20% per 40-mg/dL decline in LDL-C were seen in both
placebo-controlled and high- versus low-dose trials for all prespecified
patient subgroups, and at all baseline LDL-C levels (including <80 mg/dL)"
Statin risks may outweigh benefits for patients with a history of brain
hemorrhage - Science Daily, 1/10/11
Statin use associated with statistically significant reduction in colorectal
cancer - Science Daily, 10/18/10 - "The relative risk was 0.88 (95% CI
0.84-0.93; n=22) and represents a 12% reduction in the odds of colorectal cancer among statin users ... the most common category of statins, lipophilic (which
includes atorvastatin or Lipitor®), showed the greatest effect ... long-term use
of statins is associated with reduced risk of several cancers, including breast,
prostate, lung, pancreas and liver"
Regular statin use is associated with a reduced risk of developing
rheumatoid arthritis - Science Daily, 9/7/10 -
"After adjusting for other possible confounders, patients who persistently
took statins had a lower risk (risk ratio of 0.58) of developing rheumatoid
arthritis compared with patients who did not persistently take statins.
There was only a small short term decrease in risk ratio in patients taking
statins and the development of osteoarthritis. (hazard ratio of 0.85)"
Statins associated with lower cancer recurrence following prostatectomy
- Science Daily, 6/28/10 - "the data showed that
overall, statin use reduced the risk of biochemical recurrence by 30 percent
... Among men taking statins equivalent to 20 mg of simvastatin a day, the
risk of recurrence was reduced 43 percent and among the men taking the
equivalent of more than 20 mg of simvastatin a day, the risk of recurrence
was reduced 50 percent. Men who took a statin dose the equivalent of less
than 20 mg of simvastatin daily saw no benefit"
Statins May Lower Testosterone, Libido - WebMD, 4/16/10 -
"When they compared men on statins to those not, the
men on statins were twice as likely to have low testosterone, regardless of
which of three commonly used thresholds for low testosterone they looked at"
Statins May Be Linked to Diabetes Risk - WebMD, 2/17/10 -
"use of statins increased the risk of type 2
diabetes by 9%. This risk was found primarily among older people; there was
no additional diabetes risk among statin users 60 and under"
Common cholesterol drugs, statins, fight cataracts, too - Science Daily,
and Breast Cancer in Postmenopausal Women without Hormone Therapy -
Anticancer Res. 2009 Dec;29(12):5143-5148 -
"Overall, there was no association between the use of statins and breast
cancer risk odds ratio (OR)=1.3 (95% confidence interval (CI) 0.7-2.5).
However, risk varied by hormone receptor status. Compared to non-users,
obese women who used hydrophobic statins had an elevated risk of
progesterone receptor-negative (PR(-)) breast cancer OR=4.0 (95% CI
1.2-13.8), but not of tumors with other hormone receptor profiles. The risk
for breast cancer was also significantly increased among overweight women
who used hydrophobic statins for less than or equal to 4 years OR=4.1 (95%
CI 1.2-14.4). CONCLUSION: This observational study found an increased risk
of breast cancer related to duration of statins use and PR(-) among
Statins May Soon Be Given to Those With Excess Inflammation - U.S. News,
12/17/09 - "The Food and Drug Administration is
considering expanding the use of cholesterol-lowering statin Crestor to
those who have increased levels of inflammation—but not high cholesterol ...
2.8 percent of folks in the Crestor group developed diabetes compared with
2.3 percent of those who took placebos ... Experts still can't explain why
Crestor would increase the likelihood of diabetes, but other research
suggests that the entire class of statin drugs appears to have this downside
... found a 13 percent increased risk in diabetes in the statin users ...
1.5 percent of the placebo takers had a heart attack or stroke compared with
0.72 percent of the statin takers"
Statins Lower Mortality, but Not Health Services Use - Medscape,
12/10/09 - "After adjustment for clinical and
demographic variables, receipt of statins was associated with a 59%
reduction in mortality"
Long-term Statin Use Associated With Decreased Risk Of Gallstones Requiring
Surgery - Science Daily, 11/10/09 - "Use of the
cholesterol-lowering drugs statins for more than a year is associated with a
reduced risk of having gallstones requiring surgery"
Widely Used Cholesterol-lowering Drug May Prevent Progression Of Parkinson's
Disease - Science Daily, 11/9/09 - "Simvastatin,
a commonly used, cholesterol-lowering drug, may prevent Parkinson's disease
from progressing further"
Cholesterol-lowering Medicines May Be Effective Against Cancer - Science
Daily, 11/2/09 - "Our results support the idea that
statins can be used in more ways than just to lower cholesterol," says Pilon.
"Not least that they can prevent the growth of cancer cells caused by
lipid-modified proteins, but also that they can be effective in the
treatment of diabetes and neurological disorders such as Parkinson's."
Statins Show Dramatic Drug And Cell Dependent Effects In The Brain -
Science Daily, 10/28/09 - "Besides their tremendous
value in treating high cholesterol and lowering the risk of heart disease,
statins have also been reported to potentially lower the risks of other
diseases, such as dementia ... statin drugs can have profoundly different
effects on brain cells -both beneficial and detrimental ... simvastatin
reduced the expression of the cholesterol transporter ABCA1 by approximately
80% in astrocytes, while pravastatin lowered expression by only around 50%.
Another interesting difference was that while both statins decreased
expression of the Tau protein -associated with Alzheimer's disease -- in
astrocytes, they increased Tau expression in neurons; pravastatin also
increased the expression of another Alzheimer's hallmark, amyloid precursor
Statin Drugs May Cut Dementia Risk - WebMD, 7/14/09 -
"people who took statin drugs were 58% less likely
to develop dementia than those who did not ... So what is going on? A risk
factor for dementia is high insulin; one theory is that statins may lower
the high insulin levels in the brain. Statins have also been shown to reduce
levels of C-reactive protein (CRP), a marker of inflammation that has been
linked to the pathology that can lead to dementia"
Muscle Damage From Statins May Evade Blood Test - WebMD, 7/6/09 -
"Studies suggest that between 10% and 15% of
patients who take cholesterol-lowering statin drugs like Crestor, Lipitor,
Lescol, Mevacor, Zocor, and Pravachol experience muscle pain as a side
effect of treatment ... Most do not end up with muscle damage, and a simple
blood test is routinely performed to identify patients who do ... But the
new study suggests the test for elevated levels of an enzyme associated with
muscle injury, known as creatine phosphokinase or CPK, may be less accurate
than widely believed ... Our findings call into question whether normal or
mildly elevated levels of serum (CPK) can be used to exclude underlying and
possibly ongoing muscle injury"
Muscle Damage May Be Present In Some Patients Taking Statins - Science
Daily, 7/6/09 - "Although in clinical practice, the
majority of patients with muscle symptoms improve rapidly after cessation of
therapy, our findings support that a subgroup of patients appears to be more
susceptible to statin-associated myotoxicity, suffering persistent
Cholesterol OK? Statins Still Help Heart - WebMD, 7/1/09 -
"Combined data from 10 trials that included more
than 70,000 patients without cardiovascular disease, but with cardiovascular
risk factors, showed a 12% reduction in deaths among patients who took
statins ... The statin group also had 30% fewer heart attacks and 20% fewer
strokes over four years of follow-up"
Statins Can Protect Against Alzheimer’s Disease, According To New Study
- Science Daily, 6/22/09 - "They clearly
demonstrated that treatment with a statin called Lovastatin could prevent
the death of nerve cells under these conditions. The statins not only
prevented cells from dying but also prevented the loss of memory capacity
that normally occurs after such cell death. In a previous study Dolga had
showed that these statins stimulate the protective capacity of tumor
necrosis factor, which is a key player in the brain’s immune response"
- [Abstract] -
is in red yeast rice. See
red yeast rice products at iHerb.
Pretreatment with Lovastatin Prevents N-Methyl-D-Aspartate-Induced
Neurodegeneration in the Magnocellular Nucleus Basalis and Behavioral
Dysfunction - J Alzheimers Dis. 2009 Mar 6 -
"From these studies we conclude that treatment with lovastatin may provide
protection against neuronal injury in excitotoxic conditions associated with
neurodegenerative diseases including Alzheimer's disease" - Note:
Lovastatin (that's the
generic name and therefore shouldn't be capitalized) is in
red yeast rice. See
red yeast rice products at iHerb.
Statin Drugs May Protect Against Cancer And Also Result in Fewer Gallbladder
Removals - Science Daily, 5/5/09 - "The research
team found a significant inverse association between having statin
prescriptions filled and the risk of developing HCC. There was a trend
toward stronger risk reduction with longer and more frequent statin
Statins Alter Prostate Cancer Patients' PSA Levels - Science Daily,
4/28/09 - "We found that PSA levels are actually
significantly lower in prostate cancer patients on statins versus prostate
cancer patients not on statins"
Major Statin Study Reveals Several Important Findings For Reducing Prostate
Cancer And Disease - Science Daily, 4/26/09 -
"non-statin users were three times more likely to develop prostate cancer,
suggesting statin use may prevent development of prostate cancer ...
Overall, statin use was not significantly associated with a decreased risk
of developing ED. However, statins were associated with a decreased risk of
ED among older men (>60 years). Men in this age category who used statins
were less likely to develop ED, compared to older men who did not use
statins. Additionally, men who took statins for a longer time were more
protected against developing ED. For example, men who took statins for
nearly nine years or more were 64 percent less likely to develop ED, while
men who took statins for less than three years had about the same risk of
developing ED. compared to men who did not take statins" - See
Statins May Exert Influence On Prostate Cancer Growth By Reducing
Inflammation - Science Daily, 4/26/09 - "men who
were on statins had a 72 percent reduction in risk for tumor inflammation,
and we believe this might play a role in the connection between prostate
cancer and statin use" - See atorvastatin at
Statins May Lower Stroke Risk - Science Daily, 4/15/09 -
"strokes were 18% less likely among patients taking
statins than among those who didn't get statins ... For every drop of 39
mg/dL in LDL "bad" cholesterol, stroke risk dropped by 21%"
Statin study: Lower cholesterol, diminished joy of sex linked - USA
Today, 3/5/09 - "In the study, sexual pleasure sank
along with LDL levels ... Some studies have found that statins improve
sexual function, probably because the pills can improve blood flow to the
genital area, Golomb says. But she says the drugs also may reduce Coenzyme
Q10, a nutrient that helps cells convert oxygen, blood and glucose into
energy. "Orgasm is a high-energy activity," so losing the nutrient could
weaken sexual pleasure, she says" - See
Jarrow Ubiquinol at iHerb.
Aching Back? Cholesterol Medication Might Help - Science Daily, 3/3/09 -
"A new study finds that using statins may be useful
in treatment for degenerative discA new study finds that using statins may
be useful in treatment for degenerative disc ... Lovastatin increased the
synthesis of collagen II, a protein that makes up moveable joints, and
decreased the synthesis of collagen I, a protein that is related to fibrosis
(the formation or development of excess fibrous connective tissue)" -
Note: Lovastatin is the one that red yeast
rice is high in.
Statins Lower Stroke Severity, Improve Recovery - Science Daily, 2/27/09
- "patients who were taking statins before a stroke
experienced better outcomes and recovery than patients who weren't on the
drug — even when their cholesterol levels were ideal"
Statins Cut Deaths From Prostate Cancer - WebMD, 2/26/09 -
"men taking statins were 63% less likely to die from
the disease than men not taking statins ... The high-potency statins were
about 2.5 times more effective at preventing prostate cancer death than the
'Normal' levels of bad cholesterol may be too high - USA Today, 2/1/09 -
"Current guidelines recommend that doctors prescribe
a statin for anyone whose LDL is 100 milligrams per deciliter of blood or
higher ... half of all heart attacks are occurring below 100 (mg/dl) ... the
study supports the wisdom of a push to drive LDL even lower, in many cases
down to 70 mg/dl"
More May Benefit From Cholesterol Drugs - WebMD, 1/13/09 -
"Eight out of 10 middle-aged and older Americans may
benefit from treatment with cholesterol-lowering statin drugs ... All the
participants had elevated levels of high-sensitivity C-reactive protein (hsCRP)
... Over an average of two years of treatment, participants who took the
statin Crestor had half as many heart attacks, strokes, and deaths from
cardiovascular causes as participants randomly assigned to receive a
Disorders Linked To Statin Drug Use In Some Patients - Science Daily,
JUPITER hits New Orleans: Landmark study shows statins benefit healthy
individuals with high CRP levels - theheart.org, 11/9/08 -
"In a study of individuals with low LDL cholesterol
but elevated C-reactive-protein (CRP) levels, investigators showed that
rosuvastatin (Crestor, AstraZeneca) 20 mg significantly reduced the primary
end point—a composite of nonfatal MI, nonfatal stroke, hospitalization for
unstable angina, revascularization, and confirmed death from cardiovascular
causes—by 44% compared with individuals treated with placebo" - Note:
They seem to be attributing this to the reduction in CRP. At 12
months, the CRP of the 20 mg Crestor group was 2.2. The baseline
was 4.2. That's a (4.2 - 2.2)/4.2 = 47.6% reduction in CRP.
Another option to reduce CRP might be Periostat (low dose doxycycline for
periodontal disease). See my CRP
page for other ways to reduce it. See:
- Low-dose Periostat (Doxycycline) Shows Benefits in Patients with Heart Failure - Doctor's Guide, 11/20/02 -
"At six-month follow-up,
sub-antimicrobial dose doxycyline significantly reduced
CRP levels by 45.8 percent compared to baseline values (p<0.05). The drug was also associated with a 33.5 percent reduction in interleukin-6 and a 50 percent reduction in metalloproteinase ... The findings are
exciting, since research is now showing that CRP is both a key marker of inflammation leading to future acute coronary events, but also that CRP itself may contribute to the initiation and progression of atherosclerosis"
Study: Statins help people with normal cholesterol, too - USATODAY.com,
11/9/08 - "A study involving nearly 18,000 patients
has shown for the first time that giving a cholesterol-lowering statin drug
to seemingly healthy people with normal cholesterol can cut their risk of
heart attacks, stroke and death by nearly half"
Statins Lower Prostate Cancer Marker - WebMD, 10/28/08 -
"On average, PSA declined by 4.1% after starting a
statin ... a bigger decrease was seen in men who started out with the
highest PSA levels (2.5 ng/mL or more) -- but only among those who had the
greatest decrease in cholesterol. These men had a 17.4% drop in PSA"
Statins Reduce Dementia & Cognitive Impairment Risk - Physician's Weekly
Article, 10/13/08 - "Patients who had used statins
were about half as likely as those who did not use the drugs to develop
dementia or CIND"
Statins May Prevent Miscarriages, Study Suggests - Science Daily,
Top-selling Cholesterol Drug Does Little For Women, Study Suggests -
Science Daily, 9/17/08 - "Not one of the studies
that included women with a mixture of risk factors for heart attacks
provided statistically significant support for prescribing Lipitor or other
statins to protect against cardiovascular problems. Pfizer’s claims of
clinical proof that Lipitor reduces risk of heart attack in patients with
multiple risk factors for heart disease does not appear to be scientifically
supported for large segments of the female population ... Lipitor’s
advertising repeatedly fails to report that clinical trials were
statistically significant for men but not for women. Unqualified advertising
claims of protection against heart attacks may therefore be misleading"
Statins Lower Risk of Recurrent Stroke in Both Elderly, Younger Patients
- Doctor's Guide, 9/10/08 - "Within each group,
about half of the people received atorvastatin and about half received a
placebo. The participants were then followed for an average of 4.5 years ...
Low-density lipoprotein (LDL) cholesterol was lowered by an average of 61
points during the study for the elderly group, and by 59 points for the
younger group. Those in the younger group reduced their risk for another
stroke by 26% and the elderly group reduced their risk by 10%"
Cholesterol Drugs Lower Risk Of Stroke For Elderly, Too - Science Daily,
Lowering Cholesterol Early In Life Could Save Lives - Science Daily,
8/4/08 - "Our review of the literature convinces us
that more aggressive and earlier intervention will probably prevent
considerably more than 30% of coronary heart disease ... Studies show that
fatty streak lesions in the arteries that are a precursor to atherosclerosis
and heart disease begin in childhood, and advanced lesions are not uncommon
by age 30. Why not nip things in the bud?" Such early signs of heart disease
should be taken as seriously as early signs of cancer or diabetes"
Statins May Prevent Dementia in Older Adults - Doctor's Guide, 7/29/08 -
"People at high risk for dementia who took statins
were half as likely to develop dementia as those who do not take statins"
Can Statins Reduce Risk of Memory Loss? - WebMD, 7/28/08
Statins Have Unexpected Effect On Pool Of Powerful Brain Cells - Science
Statins Are "Remarkably Safe," Says New Review - Medscape, 6/10/08 -
"A new review of the safety of statins has concluded
that these drugs are well tolerated, with their main adverse effects — myopathy
and rhabdomyolysis — occurring very rarely at standard doses"
Cholesterol Leads To Lower PSA, Lower Prostate Cancer Risk, Study Suggests
- Science Daily, 5/15/08 - "PSA levels were reduced
after starting statin medications and that this decline was proportional to
the decline in LDL cholesterol"
Statins May Reduce Risk for Lung Cancer - Medscape, 5/8/08 -
"Statin use for more than 6 months was associated
with a reduced risk for lung cancer of 55%"
Reduction in Blood Pressure With Statins: Results From the UCSD Statin
Study, a Randomized Trial - Arch Intern Med. 2008 Apr 14;168(7):721-7 -
"Statins modestly but significantly reduced BP
relative to placebo,by 2.2 mm Hg for SBP (P = .02) and 2.4mm Hg for DBP"
Statins Cause Apoptosis
of Esophageal Cancer Cells - Medscape, 4/21/08
Statins Lower Blood Pressure - WebMD, 4/11/08 -
"We found that statins lower both systolic and diastolic blood pressure, and
that the effect extends to patients with pre-hypertension, with normal blood
pressure, and persons not on blood-pressure lowering medications"
Statins May Reduce Risk of Kidney Cancer - Medscape, 2/26/08 -
"Treatment with a statin was associated with a 48%
reduced risk of renal cell carcinoma"
Statins, NSAIDs vs. Prostate Cancer - WebMD, 2/18/08 -
"Men with prostate cancer who take
cholesterol-lowering statin drugs or anti-inflammatory drugs live longer
than those who don't take the drugs ... men who reported ever taking statins
were 41% to 65% less likely to die during the course of the study than men
who didn't. Men who took NSAIDs were 53% to 61% less likely to die than
those who didn't"
Why Patients Stop
Taking Statins and What Can Be Done About It - Medscape, 2/14/08 -
"Another reason why patients might stop taking
lipid-lowering therapy may be sleep disturbance, which has been associated with
statins" - That's something I didn't know. If you are taking
statins, you might want to take them in the morning instead of the evening.
Statins might reduce risk of renal cell carcinoma in humans: case-control
study of 500,000 veterans - Urology. 2008 Jan;71(1):118-22 -
"Statin use was significantly associated with a risk
reduction of renal cell carcinoma of 48% (adjusted odds ratio 0.52"
but Does It Prolong Life? - New York Times, 1/28/08 -
"High-risk groups have a lot to gain ... But
patients at low risk benefit very little if at all. We end up overtreating a
lot of patients ... This month, The Journal of the American College of
Cardiology published a report combining data from several studies of people
65 and older who had a prior heart attack or established heart disease. This
“meta-analysis” showed that 18.7 percent of the placebo users died during
the studies, compared with 15.6 percent of the statin users ... This
translates into a 22 percent lower mortality risk for high-risk patients
Association Between Statins and Cancer Incidence in a Veterans Population
- J Natl Cancer Inst. 2008 Jan 8 - "After
multivariable adjustment, a statistically significantly decreased risk of
all cancers was also associated with increasing statin use"
Statins for All Adults with Diabetes? - WebMD, 1/10/08 -
"One-third fewer people with type 1 or type 2
diabetes would suffer heart attacks or strokes if they took
cholesterol-lowering statin drugs"
Statin Drugs May Cut Cancer Risk - WebMD, 1/8/08 -
"The veterans were followed for five years, on
average. During that time, 9% of those taking statins were diagnosed with
cancer, compared with 13% of those not taking statins, VA records show"
Elderly CHD Patients and Statins - Medscape, 1/3/08 -
"the use of statins for secondary prevention in
elderly patients with documented CHD reduced all-cause mortality 22% and
reduced CHD mortality 30%. Nonfatal myocardial infarction was reduced 26%,
the need for revascularization 30%, and stroke 25%"
Statin Use Tied to Fewer Relapses in Prostate Cancer - oncologystat.com,
11/26/07 - "Men who happened to be on statins when
given radiotherapy for prostate cancer were significantly more likely to be
disease free 10 years later"
CORONA: Little Clinical Benefit Seen in First Major Statin Trial in HF -
Medscape, 11/6/07 - "Over a median follow-up of 33
months, there were no significant differences in the primary end point or in
all-cause mortality, the rate of coronary events (which included sudden
death, fatal or nonfatal MI, percutaneous coronary intervention [PCI] or
coronary arterial bypass graft [CABG], resuscitated cardiac arrest, and
hospitalization for unstable angina), effects on NYHA class, or the rate of
newly diagnosed diabetes ... Despite the lack of difference in the primary
end point, there were significant reductions in levels of CRP; however, they
were not decreased to what would be considered a low level ... This does
bring into question whether higher doses of rosuvastatin could have
additional clinical benefit" - Note: Statins do little to
increase HDL which some studies imply may be more important. Also,
statins have been shown to decrease co-enzyme Q10. I would have liked
to see the results if they had added niacin to increase HDL and co-enzyme
Statins May Fight Prostate Cancer - WebMD, 10/29/07 -
"Overall, 76% of men who took statins were alive and
without cancer 10 years after treatment vs. 66% of those who didn’t"
Cholesterol-lowering Medicine Make Radiation More Effective At Curing
Prostate Cancer? - Science Daily, 10/29/07 -
"Patients with prostate cancer who receive high-dose radiation treatment and
also take statin drugs commonly used to lower cholesterol have a 10 percent
higher chance of being cured of their cancer at 10 years after diagnosis (76
percent), compared to those who don't take these medications (66 percent)"
Statin Use Linked to Better Blood Pressure Control - Medscape, 10/23/07
- "After adjustment for demographics, body mass
index, diabetes, smoking, exercise, low-salt diet, and antihypertensive
medications, the odds ratio for having blood pressure under control was 1.46
for statin users compared with nonusers"
Statins Cut Gallstones Risk - WebMD, 10/16/07 -
"The study suggested that overall, current statin use slashed the risk of
having gallbladder removal surgery by 18% -- no matter how long a woman had
been taking the drug ... Women with diabetes who had been taking statins for
two or more years reduced their risk of surgery by 75% ... Statins improve
insulin resistance in people with diabetes but not in nondiabetics"
Cholesterol Drugs May Reduce Dementia & Parkinson's Risk - Physician's
Weekly Article, 10/15/07 - "there appears to be a
strong reduction in dementia and Parkinson’s disease incidence attributed to
the use of simvastatin, a cholesterol lowering drug. The researchers also
observed a moderate reduction in incidence of these conditions with
atorvastatin, another cholesterol-lowering drug"
Can Statins Benefit Patients With Low LDL-Cholesterol Levels? -
Physician's Weekly, 10/15/07 - "Investigators
reviewed more than 6,000 patients with LDL levels of less than 60 mg/dL.
After receiving a statin medication, patients with low LDL levels had better
survival rates than those who did not receive the agent"
Statins Reduce Loss Of Function, Keeping Old Lungs Young -- Even In Smokers
- Science Daily, 10/12/07 - "subjects taking statins
experienced a markedly slower annual decline in lung function. In FEV1,
statin users lost 10.9 ml on average, whereas nonusers lost an average of
23.9 ml each year--more than twice that of the statin group. Similarly,
statin users lost an average of 14 ml a year in FVC, whereas nonusers lost
an average of 36.2 ml ... the observed effect may be attributable to
statins' ability to reduce inflammation and smoking-induced injury in the
lung, as well as their capacity to reduce serum levels of C-reactive
protein, which relates to systemic inflammation, and to protect against
Statin Drugs: Heart Benefits Last Long - WebMD, 10/10/07 -
"Men who got inactive placebo pills during the study
had a 15.5% chance of heart attack or heart death 10 years after the study
ended. Those who got five years of statin treatment had only an 11.8% chance
of heart attack or heart death. They also had a lower risk of heart disease"
Low-Dose Aspirin Plus Statins Protects Against Colorectal Cancer -
Medscape, 10/4/07 - "Dr. Brenner's group observed a
modest risk reduction of colorectal cancer among regular users of low-dose
aspirin (adjusted odds ratio = 0.77). A stronger association was found with
regular use of statins (OR 0.65). The strongest risk reduction was seen in
subjects who used combination low-dose aspirin and statins (OR 0.63),
especially if both drugs were used for at least 5 years (OR 0.38)"
Statins May Help Alzheimer's Patients - washingtonpost.com, 9/11/07 -
"Those patients who had taken statins before they
died showed significantly lower levels of tangles in their brains ... Our
data says these drugs appear to be doing something in the human brain ...
Whether this will translate into behavioral changes, we can't say ...
subjects had taken statins for only five years or less. It may be that
longer use of statins would offer more protection"
Use of Statins and Blood Pressure - Am J Hypertens. 2007
Sep;20(9):937-941 - "Compared with people not using
statin medication, significantly more statin users had their blood pressure
under control (52.2% v 38.0%). After adjustment for demographic factors,
statin users were two times (95% confidence interval [CI], 1.46 to 2.72)
more likely to have their blood pressure under control (<140/90 mm Hg) than
nonusers. After further adjustment for body mass index, diabetes, smoking,
exercise, low-salt diet, and antihypertensive medications, the likelihood of
having blood pressure under control remained more likely among statin users
(odds ratio, 1.46; 95% CI, 1.05 to 2.05)"
Statins May Cut Alzheimer's Disease - WebMD, 8/27/07 -
"participants who had taken statins were 80% less
likely to have brain changes typical of Alzheimer's disease than those who
hadn't taken statins"
Statins May Cut Colon Cancer Recurrence - Medscape, 7/26/07 -
"Just 6 of 89 patients (6.7%) treated with any
statin relapsed, as opposed to 43 of 269 (16%) patients with no statin use"
Older Patients Reap Positive Benefits With High Dose Statins, Study Finds
- Science Daily, 7/3/07 - "The study participants
had a relative reduction in risk of 19 percent for a major cardiovascular
event with high-dose compared with low-dose atorvastatin. The important
feature is that this occurred without any evidence of increase in risk from
the high dose"
Common Drugs Cut Diabetes Nerve Damage - WebMD, 6/22/07 -
"protection was 35% for statins and 48% for fibrates --
statistically the same protection -- and these effects were independent of blood
sugar control, height, age, other things associated with neuropathy"
Statins May Cut Prostate Cancer Deaths - WebMD, 5/21/07 -
"the greater the men's cholesterol
decrease, the more their PSA levels dropped"
Treating the metabolic syndrome - Expert Rev Cardiovasc Ther. 2007
May;5(3):491-506 - "appropriate
treatment of MS components often requires pharmacologic intervention with
insulin-sensitizing agents, such as metformin and
statins and fibrates, or
angiotensin-converting enzyme inhibitors and
angiotensin II receptor blockers are
the first-line lipid-modifying or antihypertensive drugs"
Use Linked With Decreased Prostate Cancer Mortality Rates; Lower PSA Levels
- Science Daily, 5/20/07 - "PSA levels
declined by 1.1 percent for every 10 mg/dl decrease in LDL ... Reviewing PSA
levels among statin users screened in the Finnish Prostate Cancer Screening
Trial, researchers from Helsinki found a decrease in prostate cancer incidence
in this group ... A significant decrease was found in the incidence of T3
cancers ... Non-statin, lipid-lowering drugs were not associated with incidence,
stage or grade"
Cholesterol Drugs May Fight Lung Cancer - WebMD, 5/7/07 -
"People who take cholesterol-lowering
statin drugs for more than six months -- even smokers -- cut their lung cancer
risk by 55% ... Taking the drugs for four or more years cut lung cancer risk by
Drugs May Reduce Risk Of Heart Failure, Sudden Cardiac Death, New Study Suggests
- Science Daily, 5/1/07
Effects of Statin Use on Muscle Strength, Cognition, and Depression -
Medscape, 4/30/07 - "Statin nonusers
tended to perform worse on each outcome measure"
Statins Take on Advanced Prostate Cancer - Physician's Weekly, 4/2/07 -
"The use of statin drugs “was not
associated with risk of prostate cancer overall but was associated with a
reduced risk of advanced (especially metastatic or fatal) prostate cancer.” ...
The relative risk was 0.60 for less than five years of statin use and for 0.26
for five or more years of use"
Statins Protect Against Prostate Cancer - Doctor's Guide, 3/27/07 -
"Overall, prostate cancer incidence was
significantly lower for statin users than non-users (4.0% vs 8.0%,
respectively). A significant dose-response relationship was seen for the total
cumulative quantity of statin users and incidence of prostate cancer"
Cholesterol Busting Statins Also Reduce Blood Pressure - Science Daily,
3/8/07 - "the use of statins did produce
a drop in blood pressure. The overall effect of the use of statins was a 1.9
mmHg reduction in systolic blood pressure and 0.9 mmHg in diastolic blood
pressure. The effect was even more pronounced in patients with high blood
pressure (systolic over 130 mmHg) who showed an average drop of 4.0 mmHg if
treated with statins"
Everyone Be on a Statin? - Medscape, 3/6/07 -
"Patients without contraindications
should be considered for treatment with statins if their risk for cardiovascular
events exceeds 20% over a 10-year period. Patients with a 10-year risk for
cardiovascular events under 10% probably will not benefit from statin treatment.
The art of medicine applies to the large group of patients who fall between a
10% and 20% risk for events over 10 years. The current study suggests that a
significant reduction in morbidity may be achieved in these patients, but if a
reduction in mortality associated with statin therapy in this population exists,
many patients will require statin therapy over significant time periods to
achieve a benefit"
Statin Therapy Cuts Bad Cholesterol Unprecedented 70% - Doctor's Guide,
2/27/07 - "40 mg of rosuvastatin and 10
mg ezetimibe ... Crestor and Zetia reduced mean LDL-C by an unprecedented 70%"
Biological Aging Predicts Heart Attack - WebMD, 1/11/07 -
"People who age fast -- as measured by
DNA shortening -- have a higher heart disease risk. Statin drugs may help ...
Pravachol -- one of the "statin" family of cholesterol-lowering drugs --
dramatically lowered the heart disease risk of people with shorter telomeres.
But the drug seemed to have little effect on heart disease risk in people with
the longest telomeres"
statins have a beneficial effect on the kidney? - Medscape, 1/4/07 -
"Statins appear to have a small
beneficial effect on the rate of kidney function decline (particularly in
patients with cardiovascular disease), and proteinuria"
vs. Advanced Prostate Cancer - WebMD, 12/19/06 -
"Overall, statin use didn't appear to
sway the men's chances of being diagnosed with prostate cancer ... Men taking
statin drugs were about half as likely to have advanced prostate cancer as those
not taking statins"
Drugs May Help the Healthy - WebMD, 11/27/06 -
"people without heart disease or stroke
who took statins had a nearly 30% lower risk of coronary heart event, including
heart attack, and 14% lower risk of stroke compared with those who didn't"
People Could Benefit From Statins - WebMD, 11/9/06 -
"They found treatment with a generic
statin to be cost-effective, even for people as young as 35 or as old as 85,
whose annual risk of having a major heart or stroke event was as little as 1%
... generic statins could save patients in the U.S. as much as $1,800 per year"
Use Slows Lung Function Decline In Smokers And Former Smokers - Science
Study: Statins Increase Life Expectancy - Intelihealth, 10/10/06 -
"We were surprised to find that statin
users actually lived an average two years longer despite the patients having
more health risk factors and being older than non-statin users"
statin therapy reduces risk of CHD in Japanese subjects by 33% - Medscape,
9/28/06 - "the addition of pravastatin
10 mg to a low-fat diet rich in omega-3 fatty acids reduces the risk of CHD in
Japanese individuals with moderately elevated cholesterol levels by 33%,
approximately the same reduction observed in US and European primary-prevention
trials that have used larger statin dose"
Cholesterol Drugs Fight Hepatitis C - WebMD, 7/7/06
Cholesterol Drugs May Avert Cataracts - WebMD, 6/20/06 -
"Those who took Zocor had a 72% lower
risk of nuclear cataracts. Those who took Lipitor had a 27% lower risk. Those
who took Pravachol, Lescol, and Mevacor had a combined 33% lower risk"
Statin Use Associated With Marked Decrease in Kidney Cancer Among US Veterans
- Doctor's Guide, 5/25/06 - "statins are
associated with a 44% risk reduction of kidney cancer"
Statin Therapy Benefits Hypertensive and Non-Hypertensive Patients -
Doctor's Guide, 5/18/06 - "Overall,
pooled results showed that statin therapy reduced cardiac deaths by 24%"
Cholesterol-lowering Drugs Not Associated With Increased Breast Cancer Risk
- Science Daily, 5/18/06
Statins May Improve Circulation In The Retina
- Science Daily, 5/9/06 - "Among patients taking statins, intraocular pressure was reduced
90 minutes after taking the medication and at the seven-day mark. Blood
velocity (speed) and blood flow were significantly increased in patients who
had taken statins for seven days"
Erectile Dysfunction and Statin Treatment - Medscape, 3/21/06 -
"Simvastatin was found to cause
impotency in five men with coronary artery disease, and within 1 week of
discontinuing simvastatin, sexual function was restored. The Australian
Adverse Drug Reactions Committee reported 42 cases of ED associated with
simvastatin. In contrast, in one study in men aged 49.7 years and
isolated hypercholesterolaemia [low-density lipoprotein (LDL)-C 4.3 mmol/l]
as a risk factor which used penile Doppler ultrasound in a per protocol
analysis of 50% of the cohort of 18 patients (n = 9), atorvastatin therapy
was associated with improvement in erectile function"
Statin Withdrawal Hard on the Heart - WebMD, 3/14/06 -
"people who discontinued taking the
drugs experienced rapid rises in both C-reactive protein (CRP) and LDL
Of Statins Shows Improvement In Erectile Performance Of Some Men Who
Previously Did Not Respond Well To Viagra - Science Daily, 2/23/06 -
"There did seem to be some
improvement for those who received Lipitor versus the placebo ... We
theorized that if you could make the edothelium healthier through the use of
statins -- so that there is more nitric oxide available -- you would improve
the endothelial dysfunction and Viagra would work better for the patient"
Statins: Do They Lower Risk of Infections? - ABC News, 1/25/06
- Statins do
not protect against cancer - MSNBC, 1/4/06
Cholesterol Drugs May Slow Alzheimer's - WebMD, 11/17/05 -
"Those taking cholesterol drugs had
the smallest drop in test scores ... No one was assigned to take any drug.
The researchers just tracked the patients' medications and test scores"
Statin Drug Good Bet After Heart Attack - WebMD, 11/15/05
Scientists Use Statins To Overcome Learning Disabilities In Mice -
Science Daily, 11/11/05 - "UCLA
scientists used statins, a popular class of cholesterol drugs, to reverse
the attention deficits linked to the leading genetic cause of learning
Statins Reduce Risk of Stroke and Death after Carotid Artery Surgery -
Doctor's Guide, 11/10/05
Statins Use Associated with Lower Risk of Fractures - Doctor's Guide,
40-Point Cholesterol Drop=20% Lower Heart Risk - WebMD, 9/27/05 -
"for every 40-point drop in "bad"
LDL (low density lipoprotein) cholesterol sustained over a five-year period,
the use of statins reduced the risk of heart attack, stroke, and other
heart-related complications by nearly 20%"
- Cholesterol-Lowering Drugs Also Good for Bones -
Statin Treatment Within First 24 Hours After Heart Attack Cut Mortality By
Half - Doctor's Guide, 8/29/05 -
"early treatment with a statin drug within 24 hours of having a heart attack
reduced in-hospital mortality rates by over 50%"
Statins Don't Cut Dementia Risk - Clinical Psychiatry News, 8/05 -
"Initial analyses of the
investigators' data suggested that statin use lowered the risk of dementia.
But that link disappeared in further analyses that adjusted for covariates,
particularly subject age and sex"
Cholesterol Drugs May Help After Bleeding Stroke - WebMD, 7/28/05
Statin Therapy May Lower Mortality in Heart Failure Patients - Doctor's
Guide, 7/25/05 - "during the study
period, heart failure patients on statin therapy had a risk of death that
was 22% lower than the patients receiving the other drugs"
Cholesterol Drugs May Harm Ill Diabetics - Intelihealth, 7/21/05
Statins May Not Fight Dementia - WebMD, 7/11/05
Statins Not Associated with Reduced Dementia Risk - Doctor's Guide,
7/11/05 - "Participants were on
average 75 years of age, and statin use was assessed for a median of 5
years. Statin exposure may need to occur earlier in adulthood or for longer
periods to prevent dementia"
MRI Scan Reveals How Cholesterol Drugs Work - WebMD, 7/5/05 -
"20 milligrams or 80 milligrams of
Zocor daily ... After a year and a half of treatment, MRI scans showed that
both groups ended up with similar reductions in plaque size, regardless of
the strength of their statin dose ... Reduction in the size of blood vessel
wall plaque was greater in people whose LDL cholesterol dropped below 100
Large Study Shows Link Between Statin Use and Risk of Lymphoma: Presented at
ICML - Doctor's Guide, 6/9/05 -
"Use of statins is associated with a decrease in the risk of developing any
type of lymphoma"
The Role of Statins in Preventing Stroke - Medscape, 6/7/05 -
"statins reduce stroke through
cumulative improvements in a number of different components of
atherosclerosis including effects on the endothelium, thrombosis, plaque
stability, and through anti-inflammatory effects"
Cholesterol-Lowering Drugs Still Underused - WebMD, 5/31/05 -
"Only half of the people at moderate
or high risk for heart disease are getting the recommended
cholesterol-lowering drugs that can reduce their risk of a heart attack or
Cholesterol Drugs May Prevent Colon Cancer - WebMD, 5/25/05 [Abstract]
"people who took
cholesterol-lowering statin drugs for five years cut their colon cancer risk
Amlodipine and Atorvastatin Combination May Help Relax Arteries -
Doctor's Guide, 5/20/05 - "the
calcium channel blocker amlodipine (Norvasc) and the cholesterol-lowering
agent atorvastatin (Lipitor) both reduce arterial stiffness in the small
arteries ... Stiff arteries are old arteries ... Relaxing the arteries is
beneficial for cardiovascular health"
Statin Use Linked to 51% Reduction in Breast Cancer - Medscape, 5/20/05
"The beneficial effect is seen in
more than four years of statin use ... In both the prostate and lung cancer
studies, there was a 48% to 54% risk reduction in cancer associated with
Statin Use Associated with Lower Risk of Pancreatic and Esophageal Cancer
- Doctor's Guide, 5/19/05 - "The
odds ratio was 0.44 (95% confidence interval 0.36 – 0.53) for esophageal
cancer and 0.41 (95% confidence interval 0.31 – 0.51) for pancreatic cancer.
This translates into a reduction in cancer risk of 56% and 59%,
Statin Drugs Linked to Reduced Cancer Risk - WebMD, 5/16/05 -
"During a six-year period, women who
used statins reduced their risk of breast cancer by more than half (51%)
compared with nonusers ... Statin users were 48% less likely to develop lung
cancer than nonusers ... statin use reduces the rate of prostate cancer by
Next Alzheimer's Disease Drug: Lipitor? - WebMD, 5/9/05 -
"How could Lipitor help Alzheimer's
patients? Excess cholesterol in the brain seems to play a role in
Alzheimer's disease progression"
Combination Therapy The Next Wave For Diabetic Dyslipidemia - Doctor's
Guide, 5/2/05 - "Ezetimibe and
prolonged-release nicotinic acid show the most promise so far when combined
with a statin ... extended-release form of nicotinic acid (Niaspan) ...
taking 1000 mg or 1500 mg per day experienced increases in serum
high-density lipoprotein (HDL) cholesterol levels of 19% and 24%"
Statins Urged for Diabetic Patients - Doctor's Guide, 5/2/05 -
"diabetics who are older than 40
years of age whose total cholesterol exceeds 3.5 mmol/L (135 mg/dL) should
be placed on statin therapy to achieve a 30% to 40% reduction in LDL level,
regardless of their baseline LDL level and even if they do not have overt
Men Who Take Statins Slash Risk of Advanced Prostate Cancer - Doctor's
Statins Lower Prostate Cancer Risk - WebMD, 4/18/05 -
"Compared with men who didn't take
cholesterol-lowering drugs, those who did take them had nearly one-half the
risk of developing advanced prostate cancer. Risk decreased with increasing
duration of use"
Cholesterol Drugs Help Stroke Recovery - WebMD, 4/12/05 -
"Unless there are medical reasons
not to take the drugs, all patients who suffer a stroke should be put on
statins ... people started on statin drugs within a week of a stroke were
one-and-a-half to more than twice as likely to recover and go home within 45
days as those who were not given the drugs"
High Cholesterol May Speed Prostate Cancer - WebMD, 3/17/05 -
"Our data support the notion that
cholesterol-lowering drugs -- which are widely used and fairly safe -- might
be effective in prevention of prostate cancer, or as an adjunctive therapy
... elevated cholesterol levels did not stimulate new prostate cancers but
promoted tumor growth"
Cholesterol drugs fight heart disease - MSNBC, 3/8/05 -
"Taking very high doses of a drug to
push cholesterol to very low levels can help people with heart disease avoid
strokes and heart attacks, but also can cause liver problems that limit the
ability to tolerate such intensive treatment"
Statin Therapy Lessens Complications in Angioplasty Patients - Doctor's
Grapefruit Juice and Medication Can Be a Deadly Mix
- Doctor's Guide, 1/18/05 -
"reported on a man from a northern climate who moved to Florida for the
winter ... and began drinking two to three glasses of grapefruit juice each
day. Two months later the man died, the victim of a deadly interaction
between grapefruit juice and his cholesterol-lowering medication"
- Cholesterol Drugs May Lower Alzheimer's Risk -
WebMD, 1/10/05 -
"long-term use of the cholesterol-lowering drugs may help reduce risk of
memory-robbing deposits and Alzheimer's disease"
Bush Needs a Cholesterol Drug, Do You? - WebMD,
12/14/04 - "his total cholesterol
level was listed as 170 mg/dL,
which is considered within the normal range ... people with normal total
cholesterol but low HDL "good" cholesterol levels (below 40) had a 37%
reduction in heart attack risk over five years by taking a statin"
- Risk Of Muscle-damaging Disorder Low For Most Commonly Prescribed Statin
Drugs - Science Daily, 12/8/04
- FDA Expert Examines Cholesterol Drug Safety -
- Cholesterol-lowering Drug May Slow Alzheimer's Progression
- Science Daily, 11/17/04 -
"The cholesterol-lowering drug atorvastatin slowed down mental decline and
improved depressive symptoms in people with Alzheimer’s disease"
- Statins May Lower Blood Pressure - Doctor's Guide,
11/20/04 - "simvastatin
was associated with a 2.79-mm Hg decrease in systolic blood pressure and a
2.67-mm Hg drop in diastolic blood pressure, while pravastatin led to a
2.47-mm Hg decline in systolic blood pressure and a 2.47-drop in diastolic
- Cholesterol Medication: Are High Doses Better? -
WebMD, 11/1/04 -
"The high-dose cholesterol medication group appeared to fare better. Their
risk of heart disease events - including death, heart attack, and severe
chest pain -- was reduced by 17% compared with people receiving usual-care
- Experts: Fewer Take Statins Than Should -
Intelihealth, 10/18/04 -
"About 13 million Americans take statins -- roughly one-third of the number
for whom they're recommended ... Clinton's case shows the need for educating
more doctors to treat cholesterol more aggressively ... The president's
doctors didn't even know how to manage lipids"
- No Negative Effects on Bone Health Seen in Women Taking Statins
- Doctor's Guide, 10/5/04
- Statin Use Protects Heart Failure Patients Against Mortality Regardless of
Cholesterol Levels - Doctor's Guide, 9/16/04 -
"As possible mechanisms for this benefit, it has been suggested that statins
help improve endothelial function, including increasing endothelial nitric
oxide expression, they appear to improve autonomic nervous system function
and reduce cardiac hypertrophy and remodeling"
- Statins: The Emerging Indications -
Physician's Weekly, 9/13/04
- Study Supports Aggressive Treatment of Heart Patients with
Cholesterol-Lowering Medication - Doctor's Guide,
- Statins, But Not Cholesterol, Appears to Impact Morbidity in Heart Failure
- Doctor's Guide, 8/30/04 -
"Statin use is associated with improved outcomes"
- Cholesterol-Lowering Drugs Work for Years - WebMD,
"Overall, there was a 24% reduction in heart attack deaths and a 17%
reduction in deaths from other cardiovascular causes among patients taking
the cholesterol-lowering drug for 10 years compared with five years"
- Chest Pain? Statins May Save Heart - WebMD,
- HMG-CoA reductase inhibitors prevent bone loss in patients with Type 2
diabetes mellitus - Diabet Med. 2004
"there was a significantly smaller
annual decrease of the radial BMD in the
- Statin use in Type 2 diabetes mellitus is associated with a delay in
starting insulin - Diabet Med. 2004
"The use of statins is associated
with a delay in starting insulin treatment in patients with Type 2 diabetes
initially treated with oral
- Statin Drugs May Protect Children's Hearts -
- Statins May Provide Anti-Inflammatory Benefit in Patients with Rheumatoid
Arthritis - Doctor's Guide, 7/5/04 -
"Primary outcome measures were change in disease activity score (DAS28) ...
the DAS28 improved significantly in the group receiving atorvastatin
compared with placebo ... In addition, C-reactive protein declined by 50%"
Therapy: An Expert Interview With Eliot A. Brinton, MD - Medscape,
- Long-Term Use of Statins May Protect Against Glaucoma
- Doctor's Guide, 6/22/04
- Atorvastatin Reduces Blood CoQ10 Levels -
Medscape, 6/22/04 - "Even brief
exposure to atorvastatin causes a marked decrease in blood CoQ10
concentration ... Widespread inhibition of CoQ10 synthesis could explain the
most commonly reported adverse effects of statins, especially exercise
intolerance, myalgia, and
myoglobinuria" - See
coenzyme Q10 products.
- Cholesterol Drug May Help Rheumatoid Arthritis -
WebMD, 6/17/04 - "After six months,
the patients who took Lipitor did a bit better than the others. They had
lower scores on a medical index of rheumatoid arthritis activity ... In
addition, the Lipitor group had lower levels of two markers of inflammation
rate and C-reactive protein"
- Cholesterol Drugs May Fight Glaucoma - WebMD,
6/14/04 - "men
who had used statins for two or more years were 40% less likely to develop
glaucoma than the others ... Use of other, non-statin cholesterol-lowering
drugs was also associated with a 41% lower incidence of glaucoma ... use of
statins can also lower the risk of developing age-related macular
degeneration, the most common cause of blindness among people over 65"
- New Study Links Common Cholesterol-Lowering Drugs To Reduced Prostate Cancer
Risk - Science Daily, 6/8/04 -
"men who have taken any amount of these drugs, known as statins, have a 58
percent lower risk of prostate cancer than men who have taken none at all"
- Statin Drugs May Cut Colon Cancer Risk - WebMD,
6/7/04 - "When
they added in those factors, "use of statins was still associated with a 46%
reduction in risk.""
- Statins Effective for Treating Acute Ischemic Stroke
- Doctor's Guide, 5/18/04
- Cholesterol Drugs May Slow MS - WebMD, 5/13/04
- Cholesterol Drugs: Cancer Fighters? - WebMD,
"taking statins appeared to decrease the risk
breast cancer by 30% in postmenopausal women"
- Statin Prescriptions Consistently Low in Elderly Patients at Cardiovascular
Risk - Doctor's Guide, 4/21/04 -
"Our observed low prescription rate of statin therapy adds to a growing body
of literature demonstrating that statin therapy is substantially underused"
- Nearly All With Type 2 Diabetes Need Statins -
WebMD, 4/19/04 -
"no matter how low the cholesterol count, nearly all people with diabetes
should take these cholesterol-lowering drugs"
- Statins Fight Vision Loss - WebMD, 4/15/04
- Statins and Aspirin May Protect Against Severe Vision Loss in Elderly
- Doctor's Guide, 4/13/04 - "those
patients already taking statins were half as likely as those without statins
to develop the more severe wet AMD, caused by the growth of new blood
vessels underneath the retina"
- Inverse Relationship Observed Between Statin Treatment and Risk of Hip
Fracture - Doctor's Guide, 3/12/04 -
"The risk of hip fracture decreased as the number of statin prescriptions
increased ... 0.72 ... for subjects who redeemed more than 3 statin
- Statin Dosing Rarely Meets Recommended Therapeutic Goals
- Doctor's Guide, 3/9/04 - "in
clinical practice statins are routinely underdosed,
thus significant numbers of patients never receive the protective benefits
of these agents"
- High-Dose Statin Therapy Superior to Lower Dose Treatment, Reduces Mortality
- Doctor's Guide, 3/9/04
- Intensive Statin Therapy Resulted in Higher Risk Reduction of Major Cardiac
Events or Death Than Standard Statin Therapy in Patients with Acute Coronary
Syndromes - Doctor's Guide, 3/9/04
- Aggressive Lipid-Lowering Decreases All-Cause Mortality
- Medscape, 3/8/04 -
"Patients were randomized to 40 mg pravastatin (standard therapy) or 80 mg
atorvastatin (intensive therapy) ... All-cause mortality was reduced by 28%
in the aggressive-treatment arm ... At the time of randomization, the median
LDL cholesterol level in each group was 106 mg/dL"
- Preoperative Statin Therapy Benefits Patients Undergoing Vascular Surgery
- Doctor's Guide, 3/8/04 -
"preoperative treatment with statins appears to be associated with a shorter
hospital stay, improved long-term survival, and trends towards fewer
myocardial infarctions (MIs)
and combined cardiovascular end points"
Intensive versus moderate lipid lowering with statins after acute coronary
syndromes - NEJM, 3/8/04
- 'Statin' Cholesterol Drugs Lower Stroke Risk -
WebMD, 3/4/04 -
"Statin therapy should now be considered routinely for all patients at high
risk of stroke, irrespective of their initial cholesterol concentrations or
the presence of heart disease"
Effect of Intensive Compared With Moderate Lipid-Lowering Therapy on
Progression of Coronary Atherosclerosis - JAMA, 3/3/04
- Intensive Statin Therapy Stops Plaque Buildup -
WebMD, 3/2/04 - "compared the
effects of intensive statin therapy using 80 mg daily of Lipitor vs. a more
moderate approach using 40 mg of Pravachol ... the most significant finding
was that plaque buildup within the arteries stalled among the patients on
high-dose statin therapy and there was no progression of atherosclerosis in
- Statins May Help Heart Failure Patients Too -
- Statins May Protect against Cognitive Impairment after Stroke
- Doctor's Guide, 2/10/04
- Statins May Improve Neurologic Outcomes After Ischemic Stroke
- Doctor's Guide, 2/9/04
- Statins and ACE Inhibitors can Save Lives and Limbs for Leg-Bypass Patients
- Doctor's Guide, 1/27/04
- Statins May Help Prevent Bone Fractures - WebMD,
1/26/04 - "statin users had a
38%-81% lower risk of hip bone fractures and a 5%-51% lower risk of nonspinal
fractures ... statin use was associated with a 57% reduction in the number
of hip fractures reported and a 31% reduction in
- Statins: A New Therapy for Depression? -
Physician's Weekly, 12/8/03 -
"adult patients with underlying coronary artery disease (CAD) who
continuously used statins were 30% to 40% less likely to be at risk for
depression, anxiety, and hostility"
- Reason for concern? - Wellness Insider, 11/25/03 -
feels the potential side effects of statins, which include liver dysfunction,
muscle pain (rhabdomyolysis), and potentially, muscle breakdown, have been
significantly downplayed. She also feels that statins, especially at higher
doses, contribute to memory loss and to the depletion of coenzyme Q10, a
naturally occurring antioxidant-like nutrient vital to the production of
- Severe Hepatotoxicity Rare in Patients With Elevated Liver Enzymes on Statin
Therapy - Doctor's Guide, 10/31/03
- Rosuvastatin Improves Plasma Lipid Ratios -
Doctor's Guide, 10/1/03 - "Rosuvastatin
significantly more effective than atorvastatin, simvastatin, and pravastatin
in improving the ratios of total cholesterol to high-density lipoprotein
cholesterol" - See
- Rosuvastatin 10-40 mg Safe and Well Tolerated Compared to Other Statins
- Doctor's Guide, 10/1/03 - "Minor
adverse events associated with the use of rosuvastatin included myalgia in
2.1%, asthenia in 1.2%, nausea in 1.4%, dyspepsia in 0.6%, headache in 1.1%,
insomnia in 0.8%, abdominal pain in 1.2%,
in 1.1%, constipation in 1.1%, and flatulence in 0.9%"
- Rosuvastatin Improves Apolipoprotein Levels -
Doctor's Guide, 10/1/03
- Combined Fluvastatin-Fibrate Therapy Improves Lipid Profile of
Hypercholesterolaemic Patients - Doctor's Guide,
- Statins Used to Treat High Cholesterol and Osteoporosis
- Doctor's Guide, 9/30/03 -
"simvastatin acts as a double therapeutic weapon by blocking the conversion
Not only does this action increase new bone formation via the stimulation of osteoblasts,
but it also prevents the production of cholesterol" - See
- Fluvastatin Reduces Myocardial Ischemia in Patients With Coronary Heart
Disease - Doctor's Guide, 9/30/03
- Statins Decrease Aortic Stiffness in Hypertensives With High Cholesterol
- Doctor's Guide, 9/30/03 - "Most
significantly, while the PWV
remained unchanged in the pravastatin and non-statin group, it was
moderately decreased in the simvastatin group and remarkably reduced in the
fluvastatin group ... Dr.
theorized that lipophilic
statins, such as fluvastatin, reduce
aortic stiffness via three mechanisms -- decreasing serum total
cholesterol levels without reducing serum high-density lipoprotein levels,
providing powerful scavenging reactive oxygen species, as well as reducing
serum levels of low-density lipoprotein and C-reactive protein" - See
- Statins may play a role in the treatment of inflammatory rheumatic diseases
- Doctor's Guide, 9/28/03 - "the
administration of simvastatin for 8 days was associated with a rapid and
significant reduction in proteinuria levels in the three patients with
SLE, as well as in the 2 patients with systemic
vasculitis. In the five
RA, atorvastatin for 8 days was associated
with a reduction in C-reactive protein
levels and clinical improvement ... statins may have an important
therapeutic potential for different inflammatory diseases" - Note:
Red yeast rice is a non-prescription statin
but check with your doctor. See
red yeast rice products.
- Crestor (Rosuvastatin Calcium) Available in US For Treatment of Elevated
Cholesterol - Doctor's Guide, 9/16/03 -
"Crestor is available in 5 to 40 mg doses in pharmacies nationwide ... In
clinical trials, Crestor lowered LDL (low-density lipoprotein) cholesterol
or "bad" cholesterol by 45 to 63 percent (7 percent for placebo) and
increased HDL (high-density lipoprotein) cholesterol or "good" cholesterol
by 8 to 14 percent (3 percent for placebo)" - See
Crestor (rosuvastatin) at drugstore.com.
Heart Protection Study Implications for Lipid Management Guidelines and
Practices - Doctor's Guide, 9/16/03 -
"While Heart Protection Study (HPS) findings support aggressive lowering of
low-density lipoprotein (LDL) cholesterol levels and suggest optimal levels
well below current recommendations, failure to achieve current goals for LDL
cholesterol is common ... HPS findings demonstrated that a reduction of
major vascular events extended even to CAD patients with initial LDL
cholesterol levels <100 mg/dL using simvastatin 40 mg, suggesting that the
optimal LDL cholesterol level is below target levels established in current
guidelines ... rosuvastatin is more effective than other statins in
reducing LDL cholesterol" - See
- Cholesterol Drug May Ease Intermittent Claudication
- WebMD, 9/2/03 -
"Lipitor has the added benefit of improving walking ability in people with
intermittent claudication, a condition
caused by blocked leg arteries that leads to cramping and fatigue in the
legs and buttocks during exercise, such as walking"
Half of Patients Receiving Statins Achieve Maximum Benefit
- Medscape, 9/2/03 -
"less than than half of patients started on a statin are treated to
goal, and thus the promise of statins for cardiovascular disease prevention
may be largely unrealized ... the problem seems to be caused by poor
physician follow-up ... Compliance is another problem"
- Note: Red yeast rice is a
non-prescription statin. See
iHerb red yeast rice products.
- Statin, Atorvastatin, Increases Pain-Free Walking Distance In Patients With
Intermittent Claudication - Doctor's Guide, 9/2/03
- Statins Do Not Decrease Risk Of Clinical Fracture Or Bone Mineral Density In
Postmenopausal Women - Doctor's Guide, 8/19/03
- Cholesterol-Lowering Statin, Crestor (Rosuvastatin Calcium), Receives FDA
Approval - Doctor's Guide, 8/13/03
- Statins Benefit Diabetics, Regardless of Cholesterol Levels
- Medscape, 8/13/03 - "These results
show that simvastatin therapy leads to significant risk reductions for
vascular events in type 2 diabetic patients, even if they don't have
diagnosed coronary disease or high cholesterol levels. The authors estimate
that 5 years of treatment would prevent about 45 major vascular events per
1000 patients and suggest that statins should be offered to high-risk
diabetic patients regardless of their cholesterol levels"
- Heart Protection Study Supports Use of Statins In Elderly, Women, and Those
With Low LDL - Doctor's Guide, 8/1/03 -
"statin treatment significantly decreased the risk of cardiovascular
morbidity and mortality (primary endpoint) and "any major vascular event,"
including non-fatal myocardial infarction, stroke, and need for revascularisation procedures
... In older adults compared to younger adults, the
trial found similar statin benefits, with about a 25% reduction in major
vascular events regardless of age"
- Statins Help Ease Heart Failure - WebMD, 7/28/03 -
"People with heart failure may benefit from treatment with
cholesterol-lowering statin drugs even if their cholesterol levels are
normal ... One group took 5 mg of the statin Zocor for four weeks followed
by 10 mg for 10 weeks ... standard dose of Zocor in the U.S. to treat high
cholesterol is 40 mg ... researchers found significant improvements among
the patients taking the statin. Their average level of functional heart
impairment dropped from 2.39 to 2.04 on a scale of 1 to 4 ... left
ventricular ejection fraction, a measure of heart function, rose from 34% to
41%" - Note: Red yeast rice is a
non-prescription statin. See
red yeast rice products.
- FDA Advisory Committee Unanimously Recommends Approval of Lipid Lowering
Drug, Crestor (Rosuvastatin Calcium) - Doctor's
- Statins Significantly Reduce LDL levels, Ischaemic Heart Disease and Stroke
- Doctor's Guide, 7/7/03
- FDA Approves Pravigard PAC (Buffered Aspirin and Pravastatin Sodium) Tablets
For Those At Risk Of Heart Disease, Heart Attack, Or Stroke
- Doctor's Guide, 6/25/03
- Atorvastastin is Safe and Well Tolerated in Dyslipidaemic Patients
- Doctor's Guide, 6/16/03
- Statins Cut Diabetes Heart Risk - WebMD, 6/12/03
- Fluvastatin Improves Hyperlipidaemia in Nephrotic Syndrome
- Doctor's Guide, 6/11/03
- Physicians Not Aggressive Enough In The Prescribing and Monitoring of
Lipid-Lowering Agents - Doctor's Guide, 6/11/03 -
"Clearly physicians need to be more aggressive in putting patients with high
cholesterol on lipid-lowering agents, and there needs to be more vigilance
by physicians in monitoring compliance and effectiveness ... A great portion
of these patients were never adequately monitored with lab tests, so
[physicians] can't possibly know if the therapy is…effective if they don't
order lipid-monitoring tests"
- Study Compares Extended-Release Lovastatin and Atorvastatin
- Doctor's Guide, 6/10/03
- "Eye-Popping" Low-Density Lipoprotein Results from Statin Use Reported
- Doctor's Guide, 6/9/03 - "The
percent of patients achieving LDL goal was highest with atorvastatin and
lowest with lovastatin" - Yeah, but what about
HDL, which some feel is just as important if not more important.
- Statin Drugs Linked to Lower Prostate and Renal Cancer Risk
- Doctor's Guide, 6/4/03
- Cholesterol Drugs May Prevent Cancer - WebMD,
6/2/03 - "Overall, taking statins
reduces risk of developing cancer by 20%, but
that protection increases to 36% for people who take statins for four years
or more ... But the benefit stops about six months after the patient stops
taking the drug" - Note: Red yeast
rice is a non-prescription statin. See
red yeast rice products.
- Simvastatin May Retard Progression of Severe White Matter Changes
- Doctor's Guide, 5/26/03 -
"Simvastatin may slow down the progression of severe white matter changes in
the brain, and may therefore retard cognitive
decline ... The most common type of vascular dementia is due to the
hardening of the arteries deep inside the brain which causes white
matter changes... and its been shown that this can lead to executive
dysfunction" - Note: Red yeast rice
is a non-prescription statin. See
red yeast rice products.
- Previous Treatment with Statins Improves Outcome in Non-Lacunar Ischaemic
Stroke - Doctor's Guide, 5/22/03 -
"Taking statins for any reason seemed to improve the outcome of
NLIS as a whole, but especially in patients who had suffered
- Simvastatin Therapy Slows Coronary Disease Progression in Patients With and
Without Cardiovascular Risk Factors - Doctor's
Guide, 5/22/03 - "simvastatin/enalapril
therapy versus placebo resulted in decreases in mean coronary artery
diameters ... and minimum diameters ... study results support the contention
that the therapeutic effect of statin lipid lowering drugs on
seen coronary atherosclerosis is linked to the reduction of coronary events
without regard to the presence of known cardiovascular risk factors"
- Note: Red yeast rice is a
non-prescription statin. See
red yeast rice products.
- Statins Better than Antioxidants in Lowering Cholesterol in High Risk
Conditions - Doctor's Guide, 5/22/03
- Ezetimibe-Statin Combination Lowers Cholesterol Safely and Effectively in
the Elderly - Doctor's Guide, 5/17/03
- Statin Use Tied to Lower Risk for Choroidal Neovascularization with Macular
Degeneration - Doctor's Guide, 5/7/03
- Simvastatin Enhances Bone Formation And Augments Bone Mineral Density
- Doctor's Guide, 4/24/03 - "After a
year's treatment with simvastatin the increases in
bone mineral density at the lumbar spine, femoral neck and femur were
2.8, 1.0 and 0.8% respectively. In contrast, lumbar spine, femoral neck and
femur bone mineral density declined by 1.6, 1.4, and 1.2% in the control
- Niacin Extended-Release/ Lovastatin Combination Effective in Patients with
Multiple Lipid Disorders - Doctor's Guide, 4/23/03
- "Treatment by
niacin ER/lovastatin was found to be more
effective than each of its components, showing improved levels of
low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein
cholesterol (HDL-C) and triglycerides (TG)" - Note: Niacin
usually increases HDL (the good cholesterol) much more than statins.
From my own experience and from taking to others, it seems like many
physician's may ignore low HDL.
- Alzheimer's Disease: Statins May Be a New Treatment
- WebMD, 4/21/03
- Drug Combo Improves Cholesterol Levels - WebMD,
- Cholesterol Drugs: Breast Cancer Treatment? -
WebMD, 4/10/03 - "One reason cancer
cells grow so fast is that they lack biochemical brakes that slow cell
growth ... Mevacor
-- and, likely, other statins -- lets these growth-brakes build up inside
cancer cells -- making them a potentially useful
breast cancer treatment down the road"
- Rosuvastatin Improves Metabolic Syndrome Risk Factors
- Doctor's Guide, 4/9/03
- Taking Statins After Acute Ischemic Stroke Improves Outcome
- Doctor's Guide, 4/8/03
- Niacin Extended-Release Lovastatin Effective In Lowering Cholesterol
- Doctor's Guide, 4/7/03
- Ezetimibe Plus Simvastatin Reduces C-Reactive Protein in Patients with High
Cholesterol - Doctor's Guide, 4/4/03 -
"C-reactive protein is considered an
emerging risk factor and risk marker for coronary heart disease ... the
levels of C-reactive protein were about halved when the pooled
ezetimibe plus simvastatin results were compared with simvastatin alone.
The combination produced about a 34.8% reduction compared to an 18.2%
reduction if the statin was used as monotherapy"
- Atorvastatin Addition to High Blood Pressure Treatment Reduces Heart Events
- Doctor's Guide, 4/3/03
Appears Promising for MS - Medscape, 4/2/03
- Statins Have Dramatic Effect On Hypertensives With Normal Cholesterol
- Doctor's Guide, 4/2/03
- Zocor for Multiple Sclerosis Treatment - WebMD,
- Statins Have Heart Benefits in Patients With Normal Cholesterol Levels
- WebMD, 4/2/03
- Statins Appear To Have Favourable Impact On Psychological Conditions
- Doctor's Guide, 4/2/03 - "the
longer people are on the statins the more their symptoms of
depression, anxiety and hostility decrease
... When people stop taking statins or can not tolerate the medicine, their
depression, anxiety and hostility returns to pre-statin levels"
- Rosuvastatin Achieves LDL-C Goal When Other Statins Fall Short
- Doctor's Guide, 4/1/03
- Statin Treatment Lowers Risk Level Of Patients With Multi-Vessel Disease
- Doctor's Guide, 3/31/03
- Pravastatin Plays Significant Role in Preventing Progression of Coronary
Atherosclerosis - Doctor's Guide, 3/28/03
- Stroke Prevention: Statin Drugs Show Most Effect -
Statin Studies Show Mixed Results - Psychiatry News, 3/21/03
- Ezetimibe Plus Lovastatin Offers New Treatment Option For
Hypercholesterolemia - Doctor's Guide, 2/20/03
- Statins Improve Leg Functioning, Peripheral Arterial Disease Or Not
- Doctor's Guide, 2/20/03
- Statins May Have Different Effects on Platelet Function
- Doctor's Guide, 1/30/03
- Statins/Beta Blockers Impact On Certain C-Reactive Protein Levels
- Doctor's Guide, 1/29/03 - "Some
93% of the 89 patients who did not use
beta-blockers and were in
the highest CRP category and had
exercise-induced ischaemia, compared with 42%
among patients in the lower four categories. Similarly, 94% of the 67
patients who did not use
statins and were in the highest CRP category had
compared with 44% in the lower four categories"
Statin Therapy Does Not Slow Cognitive Decline - Clinical Psychiatry
News, 1/03 - "pravastatin showed no
effect at all on cognition in PROSPER. Similarly, simvastatin exerted no
impact upon cognitive decline in the earlier 20,536-patient randomized
double-blind Heart Protection Study ... It might be better to look at the
use of antihypertensives
in the elderly to prevent cognitive decline”
based upon accumulating extremely promising clinical trials data on that
score ... Prior statin trials in middle-aged patients have shown stroke
prevention but not until after 5-6 years of treatment"
- Ezetimibe Plus Simvastatin Safely Improves Lipid Profile
- Doctor's Guide, 1/17/03 -
"Ezetimibe and simvastatin given together reduced low-density lipoprotein
cholesterol by 44 to 57%, reduced
triglycerides by 20 to 28% and raised high-density
lipoprotein cholesterol by 8 to 11%, depending on the simvastatin dose"
- Ezetimibe is a
inhibitor, simvastatin is a statin.
- Bad Boy in the Blood: CRP - WebMD, 1/15/03 -
"CRP doesn't just mark risk. It contributes
to plaque formation in the blood-vessel wall. It promotes cholesterol uptake
... The most dazzling observation has been that in postmenopausal women,
even those with low cholesterol levels, CRP identifies a three-fold
increased risk for coronary artery
disease ... When they added CRP to these cells, they saw dramatic
effects. The cells began to secrete a substance called PAI-1. Increased
PAI-1 secretion predicts formation of blood clots and heart disease. It also
predicts diabetes and the pre-diabetes condition known as
metabolic disorder ... You can lower your CRP levels by doing the same
things you would do to lower your cholesterol levels: lose weight, eat fewer
calories and a very low fat diet, take the cholesterol-lowering drugs known
as statins, and the natural form of vitamin E"
- Intense Heart-Smart Program Pays Off - WebMD,
1/14/03 - "The
healthy benefits of a low-fat diet,
exercise, and cholesterol-lowering statin drugs
may be much greater in combination than alone in helping people with heart
disease prevent future heart attack,
stroke, and even death. New research shows following a strict program
that combines all three approaches can lower a person's chances of suffering
a major heart-related problem from one in three to one in 15"
- Hypercholesterolaemic Children Benefit From Early Statin Therapy
- Doctor's Guide, 1/9/03
- Atorvastatin, Simvastatin Effects Similar For Subclinical Atherosclerosis
- Doctor's Guide, 1/7/03
- Anti-Cholesterol Statins Do Not Reduce Reproductive Hormones in Women of
Child-Bearing Age - Doctor's Guide, 12/31/02
- Pravastatin Reduces Left Ventricular Mass Independently of Lipid Lowering
Effect - Doctor's Guide, 12/30/02
- Statin-Niacin Combination Counters Dyslipidaemic Cardiovascular Risk
- Doctor's Guide, 12/20/02 -
"Combined statin-niacin is a safe, tolerated therapy that lowers low density
lipoprotein cholesterol and raises high density
lipoprotein cholesterol ... At niacin doses
of at least 1000 (mean 1480) mg/day added to a constant statin regimen in 29
patients, high density lipoprotein cholesterol rose significantly (by 20
- Results in Hypertensives with Elevated Cholesterol Similar with Pravastatin,
Usual Care - Doctor's Guide, 12/18/02
- Statins Use Poor in Patients Requiring Cholesterol Management
- Doctor's Guide, 12/12/02
- Statins Raise Heart Transplant Survival - WebMD,
- Statins Favourably Affect Heat Release from Atherosclerotic Plaques
- Doctor's Guide, 11/25/02
- Statins Effective in Elderly, Too - WebMD,
11/18/02 - "Pravachol,
a statin, is an equal-opportunity drug: The elderly get the same benefit as
younger people ... patients who took 40 mg of
Pravachol every day had a 20%
reduction in heart disease death and non-fatal heart attacks. A reduction in
strokes was not seen in this study ... There were, however, two downsides to
the study: Patients taking
Pravachol were more likely to
develop new cancers during the study than patients taking dummy pills, and Pravachol
didn't protect against memory and thinking problems associated with aging"
More Evidence That Statins Cut Alzheimer's Risk - Clinical Psychiatry
- Statins May Increase Survival In Interstitial Pneumonitis
- Doctor's Guide, 11/7/02
- Atorvastatin Every Other Day as Effective as Daily Dose in Lowering
Cholesterol - Medscape, 10/25/02 -
"At 12 weeks, LDL-C levels decreased by 35% in the alternate-day and by 38%
in the daily group"
- Atorvastatin Shown to Decrease Heart Disease and Stroke in Patients with
Hypertension And Low Cholesterol - Doctor's Guide,
- Statins May Help MS Patients - WebMD, 10/7/02
- Researchers Halt Successful Study On Cholesterol, Blood Pressure
- Intelihealth, 10/11/02 -
"Researchers in the Anglo-Scandinavian Cardiac Outcomes trial were giving
the cholesterol-lowering drug atorvastatin to patients who have normal or
low levels of cholesterol but are at a risk
of a heart attack or
stroke because they have high blood pressure
or other risk factors ... patients taking the prescription drug had
significantly fewer strokes and heart attacks than those taking a placebo"
- Hearing Study Reveals Surprises - Intelihealth,
10/6/02 - "If preventing heart
disease also saves hearing, it might offer another reason to take
cholesterol-lowering drugs called statins"
- Cholesterol-Lowering Drugs Safe And Effective In Children
- Doctor's Guide, 10/1/02
- Statins Can Reverse Plaque Buildup - WebMD,
"Statin drugs can do more than just lower your LDL "bad" cholesterol. In
high enough doses, they may be able to reverse the accumulation of
artery-clogging plaques that lead to heart attack and stroke"
- FDA Looking for Grapefruit Interactions - Doctor's
Guide, 9/23/02 - "If a drug has a
large first pass effect, consuming grapefruit could cause a higher drug dose
to enter the bloodstream through any of these actions ... Two drugs Dr.
Piazza-Hepp cited as coming recently under suspicion are amlodipine, a
calcium channel blocker, and atorvastatin"
- See the
cytochrome P450 system - Ben
- Blood Test Doesn't Catch All Statin-Caused Muscle Problems
- Intelihealth, 9/20/02 -
"They have few serious side effects - many cardiologists tout them as being
safer than aspirin. But they can cause rare cases of muscle destruction,
some fatal ... a less severe form of statin-caused muscle toxicity weakens
muscle without damaging the membranes that release CK into blood ... doctors
should not dismiss statin users who have muscle pain despite a normal CK
- Rare Muscle Problem Linked to Statin Use - WebMD,
- Simvastatin Increases HDL and Apo-A1 Better Than Atorvastatin
- Doctor's Guide, 9/13/02
- Early Simvastatin Therapy Improves Endothelial Function
- Doctor's Guide, 9/13/02
- Simvastatin Protects against Endothelial Dysfunction in Type 2 Diabetes
- Doctor's Guide, 9/5/02
- Simvastatin Improves Cholesterol Profile more than Atorvastatin in the
Metabolic Syndrome - Doctor's Guide, 9/4/02
- Cholesterol drug cited in nerve study - USA Today,
8/21/02 - "The
drugs, called statins, raise a person's risk of nerve damage by nearly 15%,
or roughly one case for every 2,200 patients age 50 or older"
- Statin side effect rare, but be aware - USA Today,
- Statins Benefit Patients at Risk for Coronary Disease, Even When Cholesterol
Levels Are Normal - Medscape, 7/30/02 -
"20,536 British patients (75% male; age range, 40 to 80) with total
cholesterol levels of at least 135 mg/dL
were randomized to receive simvastatin (40 mg daily) or placebo for 5 years
... Five-year all-cause mortality was significantly lower in the simvastatin
group than in the placebo group (12.9% vs. 14.7%) -- a difference
attributable mainly to a significantly lower coronary death rate"
- Pravastatin Therapy May Help Protect Kidney Function In Patients With
Well-Controlled Hypertension - Doctor's Guide,
- Mayo Clinic Study Finds No Statistically Significant Benefit for Statins in
Reducing Risk of Alzheimer's Disease - Doctor's
- Statin Use Associated with 39 percent Reduction in Risk of Alzheimer's
Disease - Doctor's Guide, 7/23/02
- Relation of Statin Use and Bone Loss: A Prospective Population-Based Cohort
Study in Early Postmenopausal Women - Doctor's
- Alternatives to HRT - WebMD, 7/10/02 -
"A powerful class of drugs called statins reduce the amount of cholesterol
in the blood -- especially LDL, the so-called "bad" cholesterol. Statins
have also been found to reduce stroke, may
reduce osteoporosis, could be an adjunct treatment for cancer ."
- Cholesterol drugs may work on brain - USA Today,
7/9/02 - "too much cholesterol in
the blood can clog arteries in a process that can lead to a heart attack.
But many researchers now think that high blood cholesterol also affects the
brain ... Excess cholesterol may be instrumental in the formation of senile
plaque ... That plaque, the hallmark of
Alzheimer's, is an abnormal cluster of dead or dying brain cells and
toxic proteins that short-circuit memory and other crucial brain functions
... People taking statins reduced their risk of
developing Alzheimer's by nearly 80%"
- Wider Guidelines Urged for Statins - WebMD, 7/5/02
say prescribing statins to a wider range of people could reduce heart attack
and stroke rates by at least a third ... The clear message from this study
is: 'Treat risk -- not cholesterol level,' ... These findings should tear up
the rule book on statin prescribing"
- Zocor (Simvastatin) Saves Lives In High-Risk Patients, Regardless Of
Cholesterol Level, Study In Lancet Shows - Diabetics, Women, Elderly Benefit
In Largest Cholesterol Study Ever - Doctor's
Guide, 7/5/02 - "simvastatin given
daily at 40 mg reduced the risk of
heart attack and stroke by about one-fourth
over the treatment period, which averaged 5.3 years ... When adjusted for
non-compliance (inadvertent or deliberate failure to take medication) in the
trial, investigators estimate that the risk reduction among this broad
population is one-third ... Not only did we find that cholesterol-lowering
treatment can protect a far wider range of people than was previously
thought, but that the therapy we used in the study can prevent stroke as
well as heart attack, in patients at risk of
CHD even in people with
already moderate or low cholesterol levels ... Patients with average or low
cholesterol levels also achieved
CHD risk reductions of about
a quarter. When adjusted for non-compliance, Oxford researchers estimate
that the risk of heart attack and stroke in this group would be reduced by
- Statins Protection Much Wider Than Thought -
Doctor's Guide, 7/4/02
- Dutch Study Bolsters Evidence That Statins Help After Angioplasty
- Intelihealth, 6/26/02
Statins May Decrease Alzheimer's Risk by 79% - Clinical Psychiatry News,
- Vasoreactivity In Type 2 Diabetes Does Not Improve With Atorvastatin Therapy
- Doctor's Guide, 5/21/02
- Cholesterol Drugs Have Painful Problem - WebMD,
- Low-Dose Atorvastatin Safe and Effective in Children
- Doctor's Guide, 5/7/02
- Eight Year Follow-Up Shows Safety/Efficacy of Cholesterol-Lowering
Pravastatin - Doctor's Guide, 4/22/02
- Cholesterol-lowering drugs may avert Alzheimer's -
USA Today, 4/18/02
- Statins May Help Prevent Alzheimer's Disease -
Doctor's Guide, 4/16/02
- New Test Predicts Sudden Death Risk - WebMD,
4/15/02 - "those who suffered sudden
cardiac death had higher levels of a substance called C-reactive protein
(CRP) ... CRP is released when blood vessels are inflamed ... the findings
of this study show that the levels of CRP in the blood are even more telling
than once thought ... we can intervene with lifestyle counseling and drugs
like statins and aspirin"
- Statin Drugs May Fight Alzheimer's, Too - WebMD,
4/9/02 - "Statins
block the vasoconstrictive [blood-vessel narrowing] effect of the A-beta
protein -- a critical protein involved in
Alzheimer's disease ... These drugs appear to have
anti-inflammatory properties, independent of their benefit in lowering
cholesterol, that may help protect against dementia" - Note:
Red yeast rice is a non-prescription statin.
- Combining Statin With Estrogen May Maximise Post-Menopausal Cardiovascular
Benefits - Doctor's Guide, 4/5/02 -
estrogen alone increased the median level of
C-reactive protein from 0.27 to 0.46 mg/dL, equivalent to a 70 percent
rise. On the other hand, simvastatin decreased C-reactive protein levels
from 0.29 to 0.28 mg/dL. Oral estrogen combined with simvastatin increased
C-reactive protein levels by 29 percent from 0.28 to 0.36 mg/dL" -
Note: Red yeast rice is a
- Statins May Inhibit Calcium Growth on Aortic Valve in Elderly
- Doctor's Guide, 3/29/02 -
"People who take statins may have at least 60 percent less aortic valve
calcium than people who do not take statins"
- Lipitor (Atorvastatin Calcium) Reduces C-Reactive Protein In Acute Coronary
Syndrome - Doctor's Guide, 3/19/02
- Risk of Fracture Reduced in Women Using Statins -
Doctor's Guide, 3/19/02 - "Fracture
risk is reduced by 60 percent in women using 3-hydroxy-3-methylglutaryl
coenzyme A reductase
inhibitors (statins) ... This substantial risk reduction is greater than
might be anticipated from increases in bone mineral density (BMD)
- Statins May Preserve Brain Power - WebMD, 3/18/02
- "The study also found that statin
use was associated with a lower risk of memory problems or dementia,
regardless of total cholesterol level. The authors say more research is
needed to understand exactly how statins seem to protect the brain, but they
suspect that the drugs may work by improving muscle function and reducing
Statin Use, Bone Mineral Density, and Fracture Risk: Geelong Osteoporosis
Study - Archives of Internal Medicine, 3/11/02 -
"The substantial 60% reduction in fracture risk associated with statin use
is greater than would be expected from increases in
- Stopping Statins May Cause Rebound that Triples Risk of Death
- Doctor's Guide, 3/5/02
- Stopping Statins Can Be Deadly - WebMD, 3/4/02 -
"the study adds evidence that statins may do more than just lower
cholesterol, and that the drugs may protect the heart in other important
ways ... recent research has shown that statins can reduce harmful
inflammation in the arteries that can lead to blood clots ... also supports
the idea that statins increase the release of protective nitric oxide in the
inner walls of the heart. Animal research has shown that when the statins
are suddenly withdrawn, a rebound effect occurs, and the nitric oxide levels
drop below normal -- increasing the risk of heart attack or other cardiac
- Lipid-Lowering Agents Cut Dementia Risk With No Indication Bias
- Doctor's Guide, 2/22/02
- Beta-Blockade Adds Value For Hypercholesterolemics On Statins
- Doctor's Guide, 2/15/02
- Pravastatin Mortality Benefit In Patients With And Without Heart Disease
- Doctor's Guide, 2/14/02
- Rosuvastatin More Effective Than Atorvastatin In Hypercholesterolemic
Patients - Doctor's Guide, 2/13/02
- FDA Approves Pravachol (Pravastatin) 80 mg for Heart Disease
- Doctor's Guide, 2/11/02
- Diet, Cholesterol Drug Combo Works Best - WebMD,
2/5/02 - "Drugs usually can lower
cholesterol more than a healthy diet. But combining the two gives you the
best effect ... the drug [Zocor]
had some potentially harmful effects on antioxidant levels. Antioxidants
help get rid of toxic chemicals produced in the body that may increase the
risk of heart disease and even cancer. Zocor
decreased levels of the antioxidants vitamin E, beta-carotene and
ubiquinol-10 ... When the drug was taken alone, there also was another
concerning finding. It increased insulin levels and raised insulin
resistance ... The diet did not increase insulin levels or insulin
resistance. In fact, it lowered both of them. This suggests that the diet
may help prevent diabetes. Plus, the Mediterranean diet helped keep insulin
levels and insulin resistance normal in men taking
- Lescol/LescolXL (Fluvastatin) Maintains Favorable Efficacy/Safety Profile in
Lipid Management - Doctor's Guide, 1/18/02
(Colesevelam) Combination With Lipitor (atorvastatin) Cuts Cholesterol
Levels Significantly - Doctor's Guide, 12/27/01
Patients on Statins Experience Fewer Lower Extremity Infections
- Doctor's Guide, 12/19/01
Treatment In Coronary Heart Disease Lowers Levels Of Marker C-Reactive
Protein - Doctor's Guide, 11/29/01
- Cholesterol-Lowering Drugs Help - Intelihealth,
- Cholesterol Drugs Also May Work for Alzheimer's -
With Simvastatin Results In Artery Plaque Stabilization
- Doctor's Guide, 11/12/01
(Colesevelam) Effective in Reducing Low Density Lipoprotein Cholesterol
- Doctor's Guide, 10/22/01
- Hormone Therapy May Increase Risk of Gallstones -
WebMD, 10/1/01 -
"women taking statins -- the most popular type of cholesterol-lowering drug
-- had a 45% drop in the chance they would need gallbladder surgery"
Analysis Underscores Safety, Efficacy of Lescol (Fluvastatin)/Lescol XL For
Cholesterol Reduction - Doctor's Guide, 9/10/01
- Study Backs Cholesterol Drug Safety -
- International Lipid Information Bureau Stands Behind Statin Safety
- Doctor's Guide, 9/4/01
(Rosuvastatin) Superior Impact On Lipid Levels Confirmed
- Doctor's Guide, 9/3/01
College of Cardiology/Heart Association Reassure Statins Safe, Effective
- Doctor's Guide, 8/30/01
- Cholesterol-lowering drugs' safety defended - USA
- Cholesterol Drug Warnings Urged - Intelihealth,
8/21/01 - "For most of the 8 million
Americans taking a statin other than Baycol, the benefits still outweigh the
Group wants warning on cholesterol drugs - CNN, 8/10/01 -
"Washington D.C.-based Public Citizen says the class of drugs known as
statins are responsible for an additional 50 deaths in the United States and
should carry a more significant warning label ... Statins work by blocking a
liver enzyme that causes cholesterol. In very rare instances it has been
linked to a disease called Rhabdomyolysis, a potentially life threatening
disease in which muscle cells are destroyed and released into the blood
stream. In the worst-case scenario it causes patients to develop kidney
- Cholesterol-Lowering Drug Baycol Pulled Off the Market
- WebMD, 8/8/01
(Cerivastatin) Not To Be Used In Combination With Gemfibrozil, Says Bayer
- Doctor's Guide, 7/25/01 - "Statins
are known to cause a rare side effect of muscle breakdown ... In a very
small percentage of patients, there is a risk of muscle breakdown resulting
in kidney damage, which in rare instances can lead to life-threatening
kidney failure ... The risk of muscle breakdown is greater in patients
as well as other fibric
acid derivatives (a group of cholesterol-lowering drugs), cyclosporine (an
immunosuppressant), erythromycin (an antibiotic),
or lipid-lowering doses of niacin (nicotinic acid) together with statins
- Cholesterol drug has wider benefit - USA Today,
6/28/01 - [in addition to lowering
cholesterol] "Cholesterol-lowering drugs, called statins, apparently work by
reducing levels of a chemical known as C-reactive protein. This protein
causes inflammation, promotes blood clotting and weakens fat-encased
blockages inside arteries, causing them to burst"
- Blood Test Could Save More From Heart Attacks -
- Blood Test Could Indicate Who Might Benefit From Cholesterol-Lowering Drugs
- Intelihealth, 6/27/01 -
"Half of all heart attack patients have normal cholesterol levels. A blood
test can detect high levels of C-reactive protein - a sign of inflammation
... Statins block an enzyme needed to make cholesterol in the liver. They
also reduce levels of C-reactive protein"
(Atorvastatin) Lowers Levels of LDL-Cholesterol in Women
- Doctor's Guide, 6/21/01
- Statins May
Be Effective For Controlling Blood Pressure -
Doctor's Guide, 6/21/01 - "statin
treatment caused a significant (p<0.05) lowering of ambulatory systolic
blood pressure (SBP) on the 24-hour (-4 mm Hg), daytime (-5 mm Hg), and
nighttime (-3 mm Hg) measurements compared to baseline"
- Popular Drugs Called Statins Not Just for Cholesterol Anymore
- WebMD, 6/14/01 - "may
prevent yet another life threatening condition: deep vein thrombosis, or
Improves Graft And Patient Survival In Kidney Transplant
- Doctor's Guide, 5/28/01
Atorvastatin Lowers C-Reactive Protein In Mixed And Diabetic Dyslipidemia
- Doctor's Guide, 5/21/01
(colesevelam HCl)/Zocor (simvastatin) Combo Better Than Zocor Alone -
Doctor's Guide, 4/30/01 - "Treatment
with WelChol (3.8 grams daily) decreased LDL-cholesterol levels by 16
percent, and Zocor (10 milligrams daily) reduced mean LDL-cholesterol levels
by 26 percent; the combination appeared to be additive, with a 42 percent
Cholesterol drug may prevent Alzheimer's - CNN, 5/1/01 -
"What we found was that patients taking statins have a 60 to 70 percent
reduction in the risk of Alzheimer's disease"
Hit 'em Hard and Fast: Statins Early After Heart Attack Improve Outcomes,
Save Lives, Cholesterol-Lowering Drugs Work Even if Cholesterol Is Normal
- WebMD, 4/3/01 - "When given to
patients with mild heart attacks, the powerful cholesterol-lowering pill
Lipitor not only lowered their risk of dying from their disease, but also
significantly reduced the risk of future heart attacks and strokes"
New Drug [rosuvastatin] Takes a Sledgehammer to High Cholesterol -
Heart Attack Patients Should Start Statin Drugs Before Leaving Hospital
- WebMD, 1/23/01
Quick drug use improves heart-attack survival - USA Today, 1/23/01
Quick Drug Use Improves Heart Attack Survival Chances - Intelihealth,
1/23/01 - "In the study of 19,599
patients, those given statins at or before their release from the hospital
were about 25 percent less likely to die within a year than those who did
not receive the drugs."
One Tiny Pill Takes on Heart Attack, Stroke, and Diabetes, Are Statins the
Little Drugs That Can? - WebMD, 1/22/01
(Atorvastatin) Reduces Angina Recurrence, Urgent Re-admissions In Hospital
In-patients - Doctor's Guide, 11/16/00
Taking Statins Earlier May Reduce Risk of Heart Attack and Death -
- Statin Plus
Niacin Reduces Heart Attack Risk, Reverses Arterial Build-up
- Doctor's Guide, 11/13/01
Inflammation appears to do a number on human heart - CNN, 11/13/00 -
"For now, though, doctors at Mount Sinai Medical Center said they were
fairly certain that one cause of inflammation is high cholesterol -- and
that cholesterol-fighting drugs called 'statins' tend to help."
Taking Baycol (Cerivastatin) Reach Target Cholesterol Levels - Doctor's
Refutes Relationship Between Statins And Bone Mineral Density
- Doctor's Guide, 9/25/00
Cholesterol-Lowering Drugs May Boost Blood Vessel Growth - WebMD,
- Pravastatin Therapy Decreases the Risk of Stroke -
- Cholesterol-lowering Statins Linked To Lower Fracture Risk In Older Patients
- Doctor's Guide, 6/27/00
Cholesterol-Lowering Drug May Protect Women From Bone Fractures -
Lowering Drugs Seem to Have Benefits in Hypertension Control
- Doctor's Guide, 5/19/00 - "A
combination of lipid-lowering statins and an anti-hypertensive drug is more
effective than an anti-hypertensive drug alone in reducing blood pressure
among high-risk patients"
Atorvastatin Better than Simvastatin for Achieving Total Cholesterol Targets
- Doctor's Guide, 4/12/00
(Niacin/Lovastatin) Reduces Cholesterol, Triglyceride Levels - Doctor's
(Simvastatin) Increases HDL And apo A-I More Than Lipitor (Atorvastatin)
- Doctor's Guide, 3/15/00
Cholesterol-Lowering Drugs Prevent Deaths After Threatened Or Actual Heart
Attack - Doctor's Guide, 3/14/00
Cholesterol-lowering drugs may lead to osteoporosis treatments - CNN,
Appears To Reduce Incidence Of Stroke - Doctor's Guide, 11/9/99
Cholesterol-Lowering Drugs Provide Double Protection Against Heart Disease
- Doctor's Guide, 7/12/99
Cholesterol Lowering With Lipitor Reduces Cardiac Events - Doctor's
Cholesterol-lowering drugs may work as well as heart surgery - CNN,
Drugs, Soy Milk And Tomato Extract All Reduce Cancer Risk -
Doctor's Guide, 4/16/99
- Study Shows
Significant Difference Between Two Statins In Raising HDL
- Doctor's Guide, 8/25/98