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Anti-aging Research > Statins >
News & Research:
dose statins prevents dementia, study suggests - Science Daily, 8/31/13
- "the current study examined whether statin use was
associated with new diagnoses of dementia. The researchers used a random
sample of 1 million patients covered by Taiwan's National Health Insurance
... The adjusted hazard ratios (HRs) for dementia were significantly
inversely associated with increased daily or total equivalent statin dosage.
The HRs for the three tertiles of mean equivalent daily dosage (lowest to
highest) were 0.622, 0.697 and 0.419 vs control ... Patients who received
the highest total equivalent doses of statins had a 3-fold decrease in the
risk of developing dementia ... Almost all the statins (except lovastatin)
decreased the risk for new onset dementia when taken at higher daily doses.
A high mean daily dosage of lovastatin was positively associated with the
development of dementia, possibly because lovastatin is a lipophilic statin
while the anti-inflammatory cholesterol lowering effect of lovastatin is not
comparable to that of atorvastatin and simvastatin" - Note: The brand
names are Mevacor (lovastatin), Lipitor (atorvastatin calcium), Zocor
Statins Can Protect Against Alzheimer’s Disease, According To New Study
- Science Daily, 6/22/09 - "They clearly
demonstrated that treatment with a statin called Lovastatin could prevent
the death of nerve cells under these conditions. The statins not only
prevented cells from dying but also prevented the loss of memory capacity
that normally occurs after such cell death. In a previous study Dolga had
showed that these statins stimulate the protective capacity of tumor
necrosis factor, which is a key player in the brain’s immune response"
- [Abstract] -
Note: Lovastatin is in red yeast rice.
red yeast rice at Amazon.com.
Aching Back? Cholesterol Medication Might Help - Science Daily, 3/3/09 -
"A new study finds that using statins may be useful
in treatment for degenerative discA new study finds that using statins may
be useful in treatment for degenerative disc ... Lovastatin increased the
synthesis of collagen II, a protein that makes up moveable joints, and
decreased the synthesis of collagen I, a protein that is related to fibrosis
(the formation or development of excess fibrous connective tissue)" -
Note: Lovastatin is the one that red yeast
rice is high in.
Lovastatin Not Harmful to Patients With Liver Disease - Doctor's Guide,
Adding Niacin to Lovastatin Therapy Might Improve Efficacy for Dyslipidemia
- Doctor's Guide, 10/5/05 - "Niacin has been shown
to be one of the most effective drugs for improving levels of high-density
lipoprotein (HDL) cholesterol, or good cholesterol ... Combining the best
LDL lowering and best HDL raising drugs makes sense"
Study Compares Extended-Release Lovastatin and Atorvastatin - Doctor's
"Eye-Popping" Low-Density Lipoprotein Results from Statin Use Reported -
Doctor's Guide, 6/9/03 -
"The percent of patients achieving LDL goal was
highest with atorvastatin and lowest with lovastatin"
Niacin Extended-Release/ Lovastatin Combination Effective in Patients with
Multiple Lipid Disorders - Doctor's Guide, 4/23/03 -
niacin ER/lovastatin was found to be more
effective than each of its components, showing improved levels of
low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein
cholesterol (HDL-C) and triglycerides (TG)"
Niacin Extended-Release Lovastatin Effective In Lowering Cholesterol -
Doctor's Guide, 4/7/03
Ezetimibe Plus Lovastatin Offers New Treatment Option For
Hypercholesterolemia - Doctor's Guide, 2/20/03
(Niacin/Lovastatin) Reduces Cholesterol, Triglyceride Levels - Doctor's
- Effects of
tocotrienol and lovastatin combination on osteoblast and osteoclast activity
in estrogen-deficient osteoporosis - Evid Based Complement Alternat Med.
2012;2012:960742 - "48 Sprague Dawley female rats
were randomly divided into 6 groups ... Delta-tocotrienol plus lovastatin
treatment significantly increased bone formation and reduced bone resorption
compared to the other groups. Therefore, the combined treatment may have
synergistic or additive effects and have the potential to be used as an
antiosteoporotic agent in patients who are at risk of both osteoporosis and
hypercholesterolemia, especially in postmenopausal women" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
Pretreatment with Lovastatin Prevents N-Methyl-D-Aspartate-Induced
Neurodegeneration in the Magnocellular Nucleus Basalis and Behavioral
Dysfunction - J Alzheimers Dis. 2009 Mar 6 -
"From these studies we conclude that treatment with lovastatin may provide
protection against neuronal injury in excitotoxic conditions associated with
neurodegenerative diseases including Alzheimer's disease" - Note:
Lovastatin (that's the generic name and therefore shouldn't be capitalized)
is in red yeast rice. See
red yeast rice at Amazon.com.
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