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News & Research:
High-Dose Statins Reduce Gum Inflammation in Heart Disease Patients -
Science Daily, 10/2/13 - "Periodontitis and
atherosclerosis are both primarily driven by inflammation. These inflammatory
conditions tend to co-exist within individuals and their biologies may be
intertwined ... patients with heart disease or a high heart disease risk were
assigned to take either an 80 mg statin or a 10 mg statin daily for 12 weeks ...
The 59 patients included in the final analysis showed a significant reduction in
gum inflammation after as few as four weeks of treatment with the high-dose
statin. Interestingly, the improvement in gum inflammation tracked closely with
improvement in atherosclerotic disease"
use of statins reduces the risk of hospitalization for dementia -
Atherosclerosis. 2013 Oct;230(2):171-6 - "A
population-based, nested case-control study was carried out by including the
cohort of 152,729 patients from Lombardy (Italy) aged 40 years or older who were
newly treated with statins between 2003 and 2004. Cases were the 1380 patients
who experienced hospitalization for dementia disease from initial prescription
until 2010 ... Compared with patients who had very short statins coverage (less
than 6 months), those on 7-24, 25-48, and >48 months of coverage respectively
had risk reductions of 15% (OR: 0.85; 95% CI: 0.74 to 0.98), 28% (OR: 0.72; 95%
CI: 0.61 to 0.85), and 25% (OR: 0.75; 95% CI: 0.61 to 0.94). Simvastatin and
atorvastatin were both associated with a reduced risk of dementia, while no
similar evidence was observed for fluvastatin and pravastatin"
Atorvastatin Reduces Periodontal Inflammation: A Novel Pleiotropic Effect of
Statins - J Am Coll Cardiol. 2013 Sep 23 -
"Eighty-three adults with risk factors or with established atherosclerosis, who
were not taking high-dose statins, were randomized to atorvastatin 80 mg vs.
10mg in a multicenter, double-blind trial to evaluate the impact of atorvastatin
on arterial inflammation ... After 12 weeks, there was a significant reduction
in periodontal inflammation in patients randomized to atorvastatin 80 vs. 10 mg
(ΔTBR mean [95 CI], 80mg vs. 10mg group = -0.43 [-0.83, -0.02], p=0.04).
Between-group differences were greater in patients with higher periodontal
inflammation at baseline (-0.74 [-1.29, -0.19], p=0.01) and in patients with
severe bone loss at baseline (-0.61 [-1.16, -0.054], p=0.03). Furthermore, the
changes in periodontal inflammation correlated with changes in carotid
dose statins prevents dementia, study suggests - Science Daily, 8/31/13 -
"the current study examined whether statin use was
associated with new diagnoses of dementia. The researchers used a random sample
of 1 million patients covered by Taiwan's National Health Insurance ... The
adjusted hazard ratios (HRs) for dementia were significantly inversely
associated with increased daily or total equivalent statin dosage. The HRs for
the three tertiles of mean equivalent daily dosage (lowest to highest) were
0.622, 0.697 and 0.419 vs control ... Patients who received the highest total
equivalent doses of statins had a 3-fold decrease in the risk of developing
dementia ... Almost all the statins (except lovastatin) decreased the risk for
new onset dementia when taken at higher daily doses. A high mean daily dosage of
lovastatin was positively associated with the development of dementia, possibly
because lovastatin is a lipophilic statin while the anti-inflammatory
cholesterol lowering effect of lovastatin is not comparable to that of
atorvastatin and simvastatin" - Note: The brand names are Mevacor
(lovastatin), Lipitor (atorvastatin calcium), Zocor (simvastatin), etc.
Low-Dose Atorvastatin on Arterial Stiffness and Central Aortic Pressure
Augmentation in Patients With Hypertension and Hypercholesterolemia - Am J
Hypertens. 2013 Feb 28 - "50 hypertensive and
hypercholesterolemic patients were allocated to receive 10mg of atorvastatin or
placebo for 26 weeks ... At study end, aortic PWV (9.0+/-1.5 vs. 10.9+/-2.6
m/sec; P<0.001) and AIx(75) (24.9% +/- 9.7% vs 28.8% +/- 11.8%; P < 0.001) were
significantly lower in the atorvastatin group than that placebo group.
Furthermore, decreases in central aortic systolic blood pressure and pulse
pressure were evident at study-end with atorvastatin but not with placebo
(130+/-8 vs. 138+/-6mm Hg, P < 0.001; 48+/-7 vs. 53+/-6mm Hg, P < 0.05,
respectively). Atorvastatin-induced reductions in aortic PWV during follow-up
showed significant associations with changes in AIx(75) and central aortic
systolic blood pressure and pulse pressure"
Lipitor Goes Generic: What Consumers Can Expect - ABC News, 11/29/11 -
"On Wednesday, the drug's patent expires, opening
the market for cheaper, generic versions of Lipitor, which should lower costs
for consumers by about 50 percent"
Business Digest - The Daily, 9/3/11 - See the lower right corner.
Generic Lipitor is supposed to be available on November 30th. Also it
mentions a new study that questions whether Crestor beats Lipitor.
Anglo-Scandinavian Cardiac Outcomes Trial: 11-year mortality follow-up of
the lipid-lowering arm in the UK - Eur Heart J. 2011 Aug 28 -
"ASCOT-LLA was stopped prematurely after a median
3.3-year follow-up because of a 36% relative risk reduction (RRR) in
non-fatal myocardial infarction and fatal coronary heart disease (CHD) (the
primary outcome) in favour of atorvastatin and a non-significant reduction
in CV deaths (16%) and all-cause mortality (13%). After a further 2.2 years
at the end of ASCOT-BPLA, despite extensive crossovers from and to statin
usage, the RRR in all endpoints remained essentially unchanged. A median 11
years after initial randomization and years after closure of LLA, all-cause
mortality (n= 520 and 460 in placebo and atorvastatin, respectively)
remained significantly lower in those originally assigned atorvastatin (HR
0.86, CI 0.76-0.98, P= 0.02). CV deaths were fewer, but not significant (HR
0.89, CI 0.72-1.11, P= 0.32) and non-CV deaths were significantly lower (HR
0.85, CI 0.73-0.99, P= 0.03) in those formerly assigned atorvastatin
attributed to a reduction in deaths due to infection and respiratory
Rosuvastatin combined with regular exercise preserves coenzyme Q10 levels
associated with a significant increase in high-density lipoprotein
cholesterol in patients with coronary artery disease - Atherosclerosis.
2011 Mar 31 - "Atorvastatin significantly decreased
serum ubiquinol (731+/-238 to 547+/-219nmol/L, p=0.001), but rosuvastatin
(680+/-233 to 668+/-299nmol/L, p=0.834) did not" - See
Formulas, Ubiquinol QH-Absorb, 100 mg, 60 Softgels at iHerb.
Statins may prevent diabetic-related blindness, study suggests - Science
Daily, 2/17/11 - "oral treatment with the drug
atorvastatin blocked the formation of free radicals in the retina, which
restored proper levels of nerve growth factor and preserved neurons in the
retina. "It removed the break on the pro-form nerve growth factor to develop
into its mature form," she said. The drug was orally administered to rats in
doses proportional to levels given to human patients with cardiovascular
problems ... In a related study, also in the March edition of the journal
Diabetologia, El-Remessy and her colleagues found that epicathecin, a
component of green tea, also prevented the adverse actions of proNGF in the
retina. It does not affect the maturation of proNGF into NGF, explained
El-Remessy, but regulated a receptor downstream that proNGF uses to send a
signal to kill the neuron. Epicathechin prevents the death by inhibiting
that receptor. "We are still getting the same result, that we are preventing
neuronal death and restoring neuronal function, but just in a different
way,"" - See
green tea extract at Amazon.com.
Top-selling Cholesterol Drug Does Little For Women, Study Suggests -
Science Daily, 9/17/08 - "Not one of the studies
that included women with a mixture of risk factors for heart attacks
provided statistically significant support for prescribing Lipitor or other
statins to protect against cardiovascular problems. Pfizer’s claims of
clinical proof that Lipitor reduces risk of heart attack in patients with
multiple risk factors for heart disease does not appear to be scientifically
supported for large segments of the female population ... Lipitor’s
advertising repeatedly fails to report that clinical trials were
statistically significant for men but not for women. Unqualified advertising
claims of protection against heart attacks may therefore be misleading"
Statins Lower Risk of Recurrent Stroke in Both Elderly, Younger Patients
- Doctor's Guide, 9/10/08 - "Within each group,
about half of the people received atorvastatin and about half received a
placebo. The participants were then followed for an average of 4.5 years ...
Low-density lipoprotein (LDL) cholesterol was lowered by an average of 61
points during the study for the elderly group, and by 59 points for the
younger group. Those in the younger group reduced their risk for another
stroke by 26% and the elderly group reduced their risk by 10%"
Prostate Cancer Can Be Halted With Anti-inflammatory And Statin Used In
Tandem, Study Suggests - Science Daily, 4/14/08 -
"A combination of low doses of Lipitor and Celebrex
had a more potent inhibiting effect on the formation of later stage tumors
than a higher dose of either agent alone ... The results from our study
indicate that a combination of Lipitor and Celebrex may be an effective
strategy for the prevention of prostate cancer progression from the first to
the second stage"
Lipitor Linked to Bleeding After Stroke - WebMD, 12/12/07
Atorvastatin Helps Protect Kidneys in SPARCL Patients - Doctor's Guide,
11/12/07 - "Treatment of stroke patients with
atorvastatin can preserve kidney function in patients with or without
chronic kidney disease, metabolic syndrome or type 2 diabetes"
Cholesterol Drugs May Reduce Dementia & Parkinson's Risk - Physician's
Weekly Article, 10/15/07 - "there appears to be a
strong reduction in dementia and Parkinson’s disease incidence attributed to
the use of simvastatin, a cholesterol lowering drug. The researchers also
observed a moderate reduction in incidence of these conditions with
atorvastatin, another cholesterol-lowering drug"
Cholesterol Drug Change May Be Risky - WebMD, 9/5/07 -
"Compared with the patients who remained on Lipitor,
those who switched to simvastatin were 43% more likely to suffer from a
major cardiovascular event such as heart attack or stroke. They were twice
as likely to suffer strokes, and 36% more likely to have heart attacks"
Zocor vs. Alzheimer's and Parkinson's - WebMD, 7/18/07 -
"In patients over age 64, those who took Zocor were
54% less likely to get Alzheimer's disease and 49% less likely to get
Parkinson's disease than were matched patients not taking statin drugs ...
Those who took Lipitor were 9% less likely to get Alzheimer's disease"
- See simvastatin at
Older Patients Reap Positive Benefits With High Dose Statins, Study Finds
- Science Daily, 7/3/07 - "The study participants
had a relative reduction in risk of 19 percent for a major cardiovascular
event with high-dose compared with low-dose atorvastatin. The important
feature is that this occurred without any evidence of increase in risk from
the high dose"
Pill May Be Better Than Two For Treating Patients With High Blood Pressure
- Science Daily, 5/11/07 - "Adults with high blood
pressure and additional risk factors for heart disease may benefit more from
taking one tablet rather than two, if their current treatment combines the
lipid-lowering medication atorvastatin with the blood pressure-lowering
Atorvastatin Confirmed as Safe in Older Patients at Increased Cardiovascular
Risk - Doctor's Guide, 5/1/07
Atorvastatin Improves Endothelial Function, May Prevent Vascular Damage in
Patients With Type 2 Diabetes - Doctor's Guide, 9/7/06
Atorvastatin More Effective Than Simvastatin in Cutting Risk of Additional
Heart Attacks in Patients Who Had a Recent Heart Attack, New Data Suggests
- Doctor's Guide, 9/6/06
Effect of Lowering LDL Cholesterol Substantially Below Currently Recommended
Levels in Patients With Coronary Heart Disease and Diabetes - Medscape,
6/14/06 - "lowering LDL cholesterol to values well
below currently recommended levels with more intensive statin therapy is
associated with additional cardiovascular benefit ... Among patients with
clinically evident CHD and diabetes, intensive therapy with atorvastatin 80
mg significantly reduced the rate of major cardiovascular events by 25%
compared with a more moderate regimen of atorvastatin 10 mg"
Lipitor Safety Questioned in Lawsuit - WebMD, 6/9/06 -
"The two lawsuits claim that Lipitor caused lasting,
debilitating muscle and nerve problems -- including memory loss"
Atorvastatin Effective for Stroke Prevention - Doctor's Guide, 5/18/06 -
"the atorvastatin arm (265 events) showed a
significant 16% risk reduction over placebo (311 events)"
Atorvastatin Well Tolerated in Older Patients - Doctor's Guide, 4/5/06
Erectile Dysfunction and Statin Treatment - Medscape, 3/21/06 -
"Simvastatin was found to cause impotency in five
men with coronary artery disease, and within 1 week of discontinuing
simvastatin, sexual function was restored. The Australian Adverse Drug
Reactions Committee reported 42 cases of ED associated with simvastatin.
In contrast, in one study in men aged 49.7 years and isolated
hypercholesterolaemia [low-density lipoprotein (LDL)-C 4.3 mmol/l] as a risk
factor which used penile Doppler ultrasound in a per protocol analysis of
50% of the cohort of 18 patients (n = 9), atorvastatin therapy was
associated with improvement in erectile function"
Of Statins Shows Improvement In Erectile Performance Of Some Men Who
Previously Did Not Respond Well To Viagra - Science Daily, 2/23/06 -
"There did seem to be some improvement for those who
received Lipitor versus the placebo ... We theorized that if you could make
the edothelium healthier through the use of statins -- so that there is more
nitric oxide available -- you would improve the endothelial dysfunction
and Viagra would work better for the patient"
Impact of Atorvastatin on Cardiovascular Events on Older Patients Not as
Great as Benefit in Younger Patients - Doctor's Guide, 2/21/06
Atorvastatin Improves Inflammatory State of Patients with Chronic Kidney
Disease - Doctor's Guide, 11/14/05
Administration Time-Dependent Efficacy of Valsartan-Atorvastatin Combination
in Hyperlipidaemic Patients With Essential Hypertension: Presented at EMH
- Doctor's Guide, 6/22/05 -
"160-mg/day dose of valsartan ... 10 mg/day of
atorvastatin ... combination treatment significantly improved
systolic/diastolic blood pressure levels (SBP/DBP) compared to monotherapy
(17.1/10.7 vs. 13.9/9.6 mm Hg; P = .027). The same benefit was seen in terms
of pulse pressure (6.4 vs. 4.3 mm Hg ... there were large significant
increases in efficacy seen with the valsartan/atorvastatin combination dosed
at night versus morning (SBP, 23.5 vs. 11.0 mm Hg; DBP, 15.9 vs. 6.8 mm Hg;
pulse pressure, 7.8 vs. 4.1 mm Hg"
Bedtime Dosing of Atorvastatin and Valsartan Together Improves Overall
Anti-Hypertensive Effects - Doctor's Guide, 5/17/05 -
"When valsartan was dosed by itself during the day,
patients averaged a 9 mmHg fall in systolic blood pressure; daytime dosing
of both valsartan and atorvastatin resulted in a 17 mmHg reduction in the
24-hour mean of systolic and diastolic BP"
Vytorin Slashes Bad Cholesterol to Lower Levels Than Atorvastatin -
Doctor's Guide, 3/9/05
Cholesterol-lowering Drug May Slow Alzheimer's Progression - Science
Daily, 11/17/04 -
"The cholesterol-lowering drug atorvastatin slowed
down mental decline and improved depressive symptoms in people with
High-Dose Atorvastatin Associated with Worsening Glycemic Control -
Doctor's Guide, 11/10/04 -
"Atorvastatin was associated with a statistically
significant increased risk of developing an HbA1c greater than 6 -- both in
non-diabetics and in diabetics"
Atorvastatin Slows Alzheimer's Disease Progression in Pilot Study -
Doctor's Guide, 11/10/04
Drug May Slow Alzheimer's Disease - WebMD, 11/9/04
Lipitor May Aid Memory in Alzheimer's - HealthDay, 11/9/04 -
"Removing cholesterol either through the diet or
with cholesterol-lowering drugs reversed the Alzheimer's path in animals ...
80 milligrams of Lipitor ... at one year, 53 percent of the Lipitor group
had improved or stabilized vs. 28 percent of those in the placebo group.
There was also a significant improvement in depressive symptoms at the end
of the year"
No Muscle-Related Adverse Effects Seen With High-Dose Atorvastatin -
Doctor's Guide, 10/27/04
Atorvastatin Shows Preventive Effect Against Cardiovascular Events in
Diabetics - Doctor's Guide, 10/25/04
Rosuvastatin May Be Better Than Atorvastatin in Patients With Metabolic
Syndrome - Doctor's Guide, 10/25/04 -
"The benefits of
rosuvastatin were seen in levels of
low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein
cholesterol (HDL-C), apoprotein (apo) A-I and apo B, total cholesterol and
- Is Lower
Really Better for Cholesterol? - WebMD, 9/14/04 -
"high-dose Lipitor decreased
CRP by 38%, while high-dose
Zocor reduced CRP by just 17% in the current study"
Why Some Statins Work Better - Time Magazine, 9/13/04 -
"patients taking high doses of Zocor fared no better
than a low-dose group in terms of heart-attack risk, despite low LDL levels.
Why? Perhaps because Lipitor works not just by lowering cholesterol but also
by reducing inflammation, something Zocor can't do as well"
Statins May Provide Anti-Inflammatory Benefit in Patients with Rheumatoid
Arthritis - Doctor's Guide, 7/5/04 -
"Primary outcome measures were change in disease
activity score (DAS28) ... the DAS28 improved significantly in the group
receiving atorvastatin compared with placebo ... In addition, C-reactive
protein declined by 50%"
- Atorvastatin Reduces
Blood CoQ10 Levels - Medscape, 6/22/04 -
"Even brief exposure to atorvastatin causes a marked
decrease in blood CoQ10 concentration ... Widespread inhibition of CoQ10
synthesis could explain the most commonly reported adverse effects of
statins, especially exercise intolerance, myalgia, and myoglobinuria"
coenzyme Q10 products.
Atorvastatin Therapy Mediated Some Aspects of Disease Activity in Patients
with Rheumatoid Arthritis - Doctor's Guide, 6/18/04
- Statins Effectively
Lower Cholesterol, But Experts Debate First Choice - Medscape, 3/15/04 -
"HDL cholesterol levels were increased more than 10%
rosuvastatin 40 mg, nearly 5% with
atorvastatin 80 mg, 10% with 40 mg
simvastatin, and 6.4% with 40 mg
Combination May Be More Effective Than High-Dose Atorvastatin -
Medscape, 3/12/04 -
"The coadministration of
ezetimibe plus simvastatin provided
additional improvements in lipid profiles across a wide range of doses
compared with titration of atorvastatin monotherapy"
Simvastatin/Ezetimibe Combination Outperforms High Dose Atorvastatin in
Lowering Cholesterol - Doctor's Guide, 3/9/04
Atorvastatin May Improve Endothelial Function In Patients with Diabetes and
in Healthy Persons At Risk for Type 2 Diabetes - Doctor's Guide, 2/17/04
Atorvastatin Therapy May Cause Increased Lipid Peroxidation in Patients with
Type 1 Diabetes - Doctor's Guide, 12/15/03
Treatment with Lipitor Reduces LDL-C, Halving Mortality in Patients with
Diabetes and Coronary Heart Disease - Doctor's Guide, 11/14/03
High Dose Atorvastatin Stops Progression of Disease in Patients With
Symptomatic Coronary Artery Disease - Doctor's Guide, 11/12/03 -
"After 18 months of treatment, intravascular
ultrasound analysis found zero progression in the group treated with
atorvastatin, compared with 2.7% progression in the group treated with
pravastatin ... atorvastatin stopped plaque progression in each of 22
pre-determined subgroups, while "we were unable to stop progression in any
of the subgroups in the pravastatin
arm" - Yeah but the way I read the following, Zocor (simvastatin) not
only stopped but reversed progression:
Simvastatin Increases HDL-C And Apo A-I More Than Atorvastatin in Patients
With Hypercholesterolemia - Doctor's Guide, 11/10/03 -
appears to increase high-density lipoprotein cholesterol (HDL-C) and
apolipoprotein (apo) A-I significantly more than does atorvastatin in
patients with hypercholesterolaemia ... Liver toxicity occurred in
significantly fewer patients treated with simvastatin compared to
Atorvastatin Has No Clinical Effect on Gonadal or Adrenal Steroid Hormones
- Doctor's Guide, 11/3/03
Atorvastatin Appears to Reduce Arterial Stiffness in Rheumatoid Arthritis
Patients - Doctor's Guide, 10/31/03 -
"They concluded that treatment with atorvastatin
significantly reduced arterial stiffness in patients with RA but did not
reduce serum CRP"
Flexible Dosing Plan for Atorvastatin Allows Patients to Achieve Target LDL
- Doctor's Guide, 10/6/03
High-Fat Meals Reduce Rate of Atorvastatin Absorption - Doctor's Guide,
Rosuvastatin Improves Plasma Lipid Ratios - Doctor's Guide, 10/1/03 -
significantly more effective than
atorvastatin, simvastatin, and
pravastatin in improving the ratios of total cholesterol to high-density
Drug May Ease Intermittent Claudication - WebMD, 9/2/03 -
"Lipitor has the added benefit of improving walking
ability in people with intermittent
claudication, a condition caused by blocked leg arteries that leads to
cramping and fatigue in the legs and buttocks during exercise, such as
Statin, Atorvastatin, Increases Pain-Free Walking Distance In Patients With
Intermittent Claudication - Doctor's Guide, 9/2/03
Atorvastastin is Safe and Well Tolerated in Dyslipidaemic Patients -
Doctor's Guide, 6/16/03
Study Compares Extended-Release Lovastatin and Atorvastatin - Doctor's
"Eye-Popping" Low-Density Lipoprotein Results from Statin Use Reported -
Doctor's Guide, 6/9/03 -
"The percent of patients achieving LDL goal was
highest with atorvastatin and lowest with lovastatin"
Atorvastatin Addition to High Blood Pressure Treatment Reduces Heart Events
- Doctor's Guide, 4/3/03
Atorvastatin, Simvastatin Effects Similar For Subclinical Atherosclerosis
- Doctor's Guide, 1/7/03
- Atorvastatin Every
Other Day as Effective as Daily Dose in Lowering Cholesterol - Medscape,
"At 12 weeks, LDL-C levels decreased by 35% in the
alternate-day and by 38% in the daily group"
Atorvastatin Shown to Decrease Heart Disease and Stroke in Patients with
Hypertension And Low Cholesterol - Doctor's Guide, 10/11/02
Simvastatin Increases HDL and Apo-A1 Better Than Atorvastatin - Doctor's
Vasoreactivity In Type 2 Diabetes Does Not Improve With Atorvastatin Therapy
- Doctor's Guide, 5/21/02
Low-Dose Atorvastatin Safe and Effective in Children - Doctor's Guide,
Lipitor (Atorvastatin Calcium) Reduces C-Reactive Protein In Acute Coronary
Syndrome - Doctor's Guide, 3/19/02
Rosuvastatin More Effective Than Atorvastatin In Hypercholesterolemic
Patients - Doctor's Guide, 2/13/02
- WelChol (Colesevelam)
Combination With Lipitor (atorvastatin) Cuts Cholesterol Levels
Significantly - Doctor's Guide, 12/27/01
- Treatment With Simvastatin
Results In Artery Plaque Stabilization - Doctor's Guide, 11/12/01
- Atorvastatin Lowers
C-Reactive Protein In Mixed And Diabetic Dyslipidemia - Doctor's Guide,
- Lipitor (Atorvastatin)
Reduces Angina Recurrence, Urgent Re-admissions In Hospital In-patients
- Doctor's Guide, 11/16/00
- Atorvastatin Better than
Simvastatin for Achieving Total Cholesterol Targets - Doctor's Guide,
- Zocor (Simvastatin)
Increases HDL And apo A-I More Than Lipitor (Atorvastatin) - Doctor's
- Study Shows Significant
Difference Between Two Statins In Raising HDL - Doctor's Guide, 8/25/98
erectile function in a rat model of high cholesterol diet-induced
atherosclerosis by atorvastatin in a manner that is independent of its
lipid-lowering property - Andrologia. 2017 Mar 10 -
"This effect on erectile function preservation of
atorvastatin was attributed to its preservation of endothelial function,
possibly through amelioration of oxidative stress and improvement in eNOS
Atorvastatin prevents advanced glycation end products (AGEs)-induced cardiac
fibrosis via activating peroxisome proliferator-activated receptor gamma
(PPAR-γ) - Metabolism. 2016 Apr;65(4):441-53 -
"Compared with the control group, in vivo treatment with Ator significantly
retarded the AGEs-induced diastolic function and attenuated cardiac
fibrosis, α-SMA, and RAGE over expression induced by AGEs ... In this study,
we demonstrated that AGEs-induced fibroblast proliferation and
differentiation were dependent on AGEs-RAGE-ERK1/2 pathway and that
atorvastatin could block this pathway via activating PPAR-γ"
Atorvastatin ameliorates cardiac fibrosis and improves left ventricular
diastolic function in hypertensive diastolic heart failure model rats -
J Hypertens. 2014 Apr 22 - "Atorvastatin
administration ameliorates cardiac fibrosis and improves left ventricular
diastolic function in Dahl salt-sensitive rats. Lowering HSP47 by
atorvastatin via inhibition of Rho-Rho kinase pathway is suggested as a
Atorvastatin plus omega-3 fatty acid ethyl ester decreases very-low-density
lipoprotein triglyceride production in insulin resistant obese men -
Diabetes Obes Metab. 2013 Dec 3 - "In insulin
resistant, dyslipidemic, obese men, atorvastatin improves VLDL-TG metabolism
by increasing VLDL-TG FCR. The addition of 4 g/day ω-3 FAEE to statin
therapy provides further TG-lowering by lowering VLDL-TG PR" -
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
Atorvastatin improves erectile dysfunction in patients initially
irresponsive to Sildenafil by the activation of endothelial nitric oxide
synthase - Int J Impot Res. 2013 Jan 17 - "This
study aimed at comparing the effects of atorvastatin and vitamin E on
erectile dysfunction in patients initially irresponsive to sildenafil, with
investigation into the underlying possible mechanisms. Sixty patients were
randomly divided into three groups: the atorvastatin group received 80 mg
daily, the vitamin E group received 400 IU daily and the control group
received placebo capsules ... glutathione peroxidase (GPO) ... nitric oxide
(NO) ... Both atorvastatin and vitamin E showed a statistically significant
GPO increase (P<0.05) and a statistically significant IL-6 decrease
(P<0.05). Only atorvastatin showed a statistically significant increase in
NO (15.19%, P<0.05), eNOS (20.58%, P<0.01), IIEF-5 score (53.1%, P<0.001)
and Rigiscan rigidity parameters (P<0.01), in addition to a statistically
significant decrease in CRP (57.9%, P<0.01). However, SOD showed a
statistically significant increase only after vitamin E intake (23.1%,
P<0.05). Both atorvatstain and vitamin E had antioxidant and
anti-inflammatory activities. Although activating eNOS by atorvastatin was
the real difference, and expected to be the main mechanism for NO increase
and for improving erectile dysfunction" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
Atorvastatin increases exercise leg blood flow in healthy adults -
Atherosclerosis. 2011 Oct 4 - "High-dose
atorvastatin augments exercising leg hyperemia. Statins may mitigate
reductions in the exercise vasodilatory response in humans that are
associated with aging and disease"
high-intensity statin therapy with simvastatin 80 mg and atorvastatin 80 mg
in primary care - Int J Clin Pract. 2011 Feb;65(2):120-6 -
"The present study suggests that atorvastatin 80 mg
compares favourably to simvastatin in terms of efficacy and has a similar
tolerability profile. Conclusion: This retrospective observational study
suggests that despite national guidelines, atorvastatin 80 mg is used in
clinical practice and is more effective and at least as well tolerated as
simvastatin 80 mg"
Comparison of Effectiveness of Rosuvastatin Versus Atorvastatin on the
Achievement of Combined C-Reactive Protein (<2 mg/L) and Low-Density
Lipoprotein Cholesterol (<70 mg/dl) Targets in Patients With Type 2 Diabetes
Mellitus (from the ANDROMEDA Study) - Am J Cardiol. 2007 Oct
15;100(8):1245-1248 - "CRP was effectively decreased
in patients with type 2 diabetes receiving rosuvastatin or atorvastatin,
whereas rosuvastatin decreased LDL cholesterol significantly more than
Effects of Atorvastatin on vitamin D levels in patients with acute ischemic
heart disease - Am J Cardiol. 2007 Apr 1;99(7):903-5 -
"atorvastatin increases vitamin D levels. This
increase could explain some of the beneficial effects of atorvastatin at the
cardiovascular level that are unrelated to cholesterol levels"
The effects of quinapril and atorvastatin on the responsiveness to
sildenafil in men with erectile dysfunction - Vasc Med. 2006
Nov;11(4):251-7 - "International Index of Erectile
Function (IIEF) questionnaire ... Compared to placebo, quinapril (p < 0.01)
significantly improved symptoms of ED as measured by the IIEF-5
questionnaire. There was a trend toward a significant improvement in IIEF-5
Influences of statins on glucose tolerance in patients with type 2 diabetes
mellitus - J Atheroscler Thromb. 2006 Apr;13(2):95-100 -
"atorvastatin-treated group (Group A ... arbitrary
blood glucose levels increased from 147 +/- 50 (mean +/- SD) mg/dL to 177
+/- 70 mg/dL in Group A"
Effect of Atorvastatin (10 mg/day) on Glucose Metabolism in Patients With
the Metabolic Syndrome - Am J Cardiol. 2006 Jul 1;98(1):66-9 -
"in insulin-resistant, nondiabetic subjects, 6 weeks of atorvastatin (10
mg/day) resulted in significant improvement in insulin sensitivity"
Influences of statins on glucose tolerance in patients with type 2 diabetes
mellitus - J Atheroscler Thromb. 2006 Apr;13(2):95-100 -
"compared an atorvastatin-treated group (Group A, n
= 76) with a pravastatin-treated group (Group P, n = 78) ... blood glucose
levels increased from 147 +/- 50 (mean +/- SD) mg/dL to 177 +/- 70 mg/dL in
Group A ... These results suggest a predisposition to a deterioration of
glycemic control in type 2 diabetic patients treated with atorvastatin"
High-Dose Atorvastatin vs Usual-Dose Simvastatin for Secondary Prevention
After Myocardial Infarction - JAMA. 2005;294:2437-2445
Effect of atorvastatin on regional arterial stiffness in patients with type
2 diabetes mellitus - J Atheroscler Thromb. 2005;12(4):205-10 -
"Atorvastatin treatment was associated with an
improvement in the stiffness of leg arteries in type 2 diabetes mellitus.
This may partly explain the statin-mediated improvement of walking
performance in those with PAD"
Atorvastatin Decreases the Coenzyme Q10 Level in the Blood of Patients at
Risk for Cardiovascular Disease and Stroke - Arch Neurol.
"Even brief exposure to atorvastatin causes a marked
decrease in blood CoQ10 concentration.
Widespread inhibition of CoQ10 synthesis could explain the most commonly
reported adverse effects of statins, especially exercise intolerance,
myalgia, and myoglobinuria" - See
coenzyme Q10 products.
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