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Home > Anti-aging Research > Nitric Oxide

Nitric Oxide

Specific Recommendations:

• Pinnacle NoX2 at iHerb

Alternative News:

• Pycnogenol((R)), French maritime pine bark extract, augments endothelium-dependent vasodilation in humans - Hypertens Res. 2007 Sep;30(9):775-80 - "These findings suggest that Pycnogenol((R)) augments endothelium-dependent vasodilation by increasing in NO production. Pycnogenol((R)) would be useful for treating various diseases whose pathogeneses involve endothelial dysfunction" - Some say that grape seed extract is the same as Pycnogenol((R)) without the patent markup.  See Pine Bark/Pycnogenol products at iHerb and Grape seed products at iHerb.
• Pine bark extract boost for blood flow and heart health - Nutra USA, 10/18/07 - "Acetylcholine stimulates the cells of arteries to produce NO from L-arginine faster ... In turn, the NO causes the muscle surrounding arteries to relax, which results in an increase of blood vessel diameters. When subjects had taken Pycnogenol the relaxation of arteries was increased by 42 per cent as compared to the group taking placebo tablets" - See pine bark/Pycnogenol products at iHerb and Citi Choline products at iHerb.
• Why Cocoa May Help Heart Health - WebMD, 1/18/06 - "cocoa's antioxidants -- called flavonoids -- coax the body into making more nitric oxide, which relaxes the blood vessels"
• Jarrow Formulas’, Inc. Introduces ALCA 500(TM) (Acetyl-L-Carnitine Arginate Dihydrochloride) - NPI Center, 3/8/05 - "Acetyl-l-carnitine arginate (ALCA) represents an advancement in the carnitine and arginine fields as this new dietary supplement offers potential benefits in affecting levels of nitric oxide over and above the traditional benefits of carnitine" - See Jarrow Acetyl L Carnitine Arginate.
• Vitamins enhance benefits of exercise for heart - Nutra USA, 5/25/04 - "Exercise alone has been shown to increase nitric oxide in the body ... But adding the amino acid L-arginine and the antioxidants vitamins C and E to the mix significantly magnified the effect" [WebMD]
• Nitric Oxide Now -- Ask Me How -  WashingtonPost.com, 10/6/03 - "In the arteries, the innermost layer of cells releases nitric oxide to signal smooth muscle cells to dilate (increase the diameter of) the arteries. This allows blood to flow more freely, particularly during exercise ... By the 1990s, many scientists saw nitric oxide as the next great weapon for treating heart disease, impotence and even bacterial infections ... Niteworks has L-arginine and also L-citrulline, which recycles spent L-arginine by resupplying it with atoms it lost producing nitric oxide ... "Ninety dollars a month? That's obscene," Murad said. "You can probably get [vitamin] C and E for pennies a day. You can probably get arginine for about a dollar a day"" - See L-citrulline products at iHerb.
• N-acetylcysteine Improves Blood Vessels - Nutrition Science News, 5/01 - "Researchers suspect this is because NAC enhances the bioavailability of the relaxing substance nitric oxide, but because nitric oxide has a short half-life and cannot be measured by current methodology, they were unable to determine this directly. In addition, NAC may act as an antioxidant that protects nitric oxide destruction"
• A Fish Story - Nutrition Science News, 4/01 - "daily consumption of very low daily doses of EPA/DHA (120 mg/180 mg, about one standard fish oil capsule) in an enriched milk led to a 19 percent decrease in blood triglycerides and a 19 percent increase in HDL cholesterol after six weeks ... It is unclear whether EPA is superior to DHA, although EPA has proven more potent in relaxing cow coronary arteries and producing the vasodilator gas, nitric oxide, in vitro"
• Want a love potion? What to know before you try - CNN, 6/15/00 - "Tissue and animal studies of one form of ginseng, called panax, give some credence to the root's sexy reputation. A study published in the May 1995 issue of the journal British Pharmacology, for instance, concluded that substances in ginseng extract known as ginsenosides may work in a similar way to Viagra. Viagra enhances the effects of nitric oxide, which helps relax artery walls, allowing more blood flow into the penis. Ginsenosides may encourage the release of more nitric oxide."

News & Research:

• Effects of Angiotensin Converting Enzyme Inhibitor and Angiotensin II Receptor Antagonist Combination on Nitric Oxide Bioavailability and Atherosclerotic Change in Watanabe Heritable Hyperlipidemic Rabbits - Hypertens Res. 2008 Mar;31(3):575-84 - "1) vehicle (control), 2) the ACEI enalapril (E: 3 mg/kg/day), 3) the ARB losartan (L: 30 mg/kg/day) and 4) enalapril (1.5 mg/kg/day) + losartan (15 mg/kg/day) (E+L). Intra-aortic infusion of ACh produced an increase in plasma NO concentration, which was significantly greater with all the drug treatments than with the control. E increased ACh-induced NO significantly more than L (by 6.9 nmol/L, and 4.7 nmol/L, respectively). E+L increased ACh-induced NO by 9.5 nmol/L, significantly more than either E or L ... the combined treatment with an ACEI and an ARB may have additive protective effects on endothelial function as well as atherosclerotic change"
• New NO Measuring Device Deemed Useful in Clinical Practice - Medscape, 10/30/07
• Elevated Nitric Oxide In Blood Is Key To High Altitude Function For Tibetans - Science Daily, 10/30/07
• Nitric Oxide: Key To Cardiovascular And Pulmonary Function And Drug Effectiveness - Science Daily, 5/3/07 - "Nitric oxide is a molecule produced by the body that controls many functions, including the contraction or dilation of blood vessels ... Almost half of all drugs on the market today, as well as many hormone and neurotransmitters, target a specific family of cell surface receptors known as G-protein coupled receptors. The researchers believe that the presence or absence of nitric oxide or SNOs determines whether these receptors continue to function properly"
• Study Links High Levels Of Nitric Oxide To Infertility And Sperm DNA Damage - Science Daily, 6/20/06
• Hypertension Drug May Restore Cardiovascular Function In African Americans - Science Daily, 3/11/06 - "The drug [nebivolol] restores correct balance between good nitric oxide and damaging oxidative stress"
• Use Of Statins Shows Improvement In Erectile Performance Of Some Men Who Previously Did Not Respond Well To Viagra - Science Daily, 2/23/06 - "We theorized that if you could make the edothelium healthier through the use of statins -- so that there is more nitric oxide available -- you would improve the endothelial dysfunction and Viagra would work better for the patient"
• Is Trouble in Bed an Indication of Future Heart Disease? - ABC News, 10/12/05 - "In men with erectile dysfunction, nitric oxide levels are low, so blood vessels cannot expand to allow the additional blood to reach the penis"
• How Cutting Calories May Increase Longevity - WebMD, 10/13/05 - "mice that were fed 30% to 40% fewer calories produced more nitric oxide than those who followed an unrestricted diet"
• Nitric Oxide Could Extend Fertility - Science Daily, 9/8/05
• Impotence: A Red Flag for Heart Disease - HealthDay, 9/27/04 - "Nitric oxide is very important for normal erectile function ... We do know that statins improve the function of the enzyme, nitric oxide synthase, that produces nitric oxide inside the blood vessels"
• Homocysteine: How Important? - Intelihealth - "One theory is that homocysteine somehow interferes with the ability of the lining of blood vessels - called the endothelium - to secrete nitric oxide, which helps regulate blood pressure by relaxing and expanding blood vessels when blood flow increases"
• Basal Nitric Oxide Production, Release Improved By AT(1) Receptor Blockade With Valsartan - Doctor's Guide, 2/19/03
• Nitric Oxide Donor Curbs Asymptomatic Embolisation After Carotid Angioplasty - Doctor's Guide, 12/24/02
• Altered Metabolic Fate Of Nitric Oxide In Type 1 Diabetes Mellitus - Doctor's Guide, 12/3/02
• Spray [ISDN] Eases Diabetic Foot Pain - WebMD, 10/3/02 - "Although the exact cause of diabetic neuropathy is unknown, researchers believe the nerve damage is related to an impaired ability to generate nitric oxide (NO). NO is used by the body to encourage healthy blood flow and oxygen circulation"
• Four New Studies Strongly Suggest That Components From Three Types [elderberry, chokeberry and bilberry]  Of Red Berry Fruits Help Arteries - Intelihealth, 4/22/02
• Cocoa: The Next Health Drink? - WebMD, 2/15/02
• Tibetans and Viagra - the missing link? - CNN, 11/23/01
• Exercise Chemical May Cause Migraines - Intelihealth, 7/16/01 - "What seemed to trigger the headache was a spike in nitric oxide, a chemical that has been implicated before in migraine"
• Possible Cause of Preeclampsia Uncovered, Likely Linked to Low Nitric Oxide Levels in Blood - WebMD, 6/7/01

Abstracts:

• Biomarkers of arginine and lysine excess - J Nutr. 2007 Jun;137(6):1662S-8S - "Arginine supplementation is used in several disease states. In arginine-deficient states, supplementation is a logical choice of therapy. However, the definition of an arginine-deficient state is complex. For example, plasma arginine levels could be within normal range but intracellular arginine levels could be reduced because of membrane transport problems. Lysine competes with arginine for transport into the cell. In these situations, arginine supplementation of higher than required levels is proposed. Arginine has several important functions in metabolism as it is a precursor of metabolically active components such as nitric oxide (NO), ornithine, creatine, and polyamines"
• Soy Consumption, Markers of Inflammation, and Endothelial Function: A cross-over study in postmenopausal women with the metabolic syndrome - Diabetes Care. 2007 Apr;30(4):967-73 - "Short-term soy nut consumption reduced some markers of inflammation and increased plasma nitric oxide levels in postmenopausal women with the metabolic syndrome"
• The role of nitric oxide in erectile dysfunction: implications for medical therapy - J Clin Hypertens (Greenwich). 2006 Dec;8(12 Suppl 4):53-62 - "Impaired NO bioactivity is a major pathogenic mechanism of erectile dysfunction"
• Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina - Heart. 2005 Oct;91(10):1319-23 - "L-arginine dependent coronary segment vasodilatation was augmented by the antioxidant vitamin C in patients with coronary artery disease. Thus, vitamin C may have beneficial effects on nitric oxide bioavailability induced by L-arginine"
• Simvastatin not low-cholesterol diet lowers the elevated plasma nitric oxide level in hyperlipidemic patients - Asia Pac J Clin Nutr. 2004;13(Suppl):S98

Related Searches:

• Doctor's Guide search of nitric
• Doctor's Guide (2) search of nitric
• Intelihealth search of nitric
• Life Extension Foundation search
• Medline search of nitric oxide
• Medscape search of nitric
• The Natural Pharmacist search of nitric
• Nutrition Science News search
• WebMD search of nitric

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