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> C-Reactive Protein
of Coenzyme Q10 Supplementation on Pro-Inflammatory Factors and Adiponectin in
Mildly Hypertensive Patients: A Randomized, Double-Blind, Placebo-Controlled
Trial - Int J Vitam Nutr Res. 2015;85(3-4):156-64 -
"Sixty mildly hypertensive patients were randomly divided into two groups:
placebo (PG, n = 30) and coenzyme Q10 (QG, n = 30). The QG was given 1 capsule
containing 100 mg Q10 per day ... The mean enhancement in adiponectin of QG was
significantly higher than PG (from 21.1 ± 14.5 to 24.2 ± 15.5 ng/ml, P = 0.04).
Significant declines in the median of IL6 (from 23 to 16 pg/ml, P = 0.001) and
in the mean of hs-CRP were also observed in QG after intervention (from 3.53 ±
3.36 to 2.62 ± 2.51 mg/L, P = 0.03)" - See
ubiquinol products at Amazon.com.
and anti-inflammatory effects of curcuminoid-piperine combination in subjects
with metabolic syndrome: A randomized controlled trial and an updated
meta-analysis - Clin Nutr. 2015 Jan 7 -
"Supplementation with curcuminoid-piperine combination significantly improved
serum SOD activities (p < 0.001) and reduced MDA (p < 0.001) and CRP (p < 0.001)
concentrations compared with placebo. Quantitative data synthesis revealed a
significant effect of curcuminoids vs. placebo in reducing circulating CRP
concentrations (weighed mean difference: -2.20 mg/L; 95% confidence interval
[CI]: -3.96, -0.44; p = 0.01). This effect was robust in sensitivity analysis"
curcumin products at Amazon.com
piperine extract at Amazon.com.
lowering of low grade systemic inflammation and insulin resistance in metabolic
syndrome patients treated with Ginkgo biloba - Atherosclerosis. 2014 Oct 18
- "In a clinical pilot study with eleven metabolic
syndrome patients, a simultaneous decrease in hs-CRP from 8.85 ± 4.09 to 4.92 ±
2.51 mg/L (-44.4%) (p < 0.0436) and HOMA-IR from 3.07 ± 0.63 to 2.60 ± 0.51mU/L
× mg/dL (-15.3%) (p < 0.0120) as well as a beneficial change of
arteriosclerotic, inflammatory and oxidative stress biomarkers were detected
after 2-month treatment with Ginkgo biloba. Furthermore, both IL-6 (-12.9%, p <
0.0407) and nanoplaque formation (-14.3%, p < 0.0077) were additionally reduced"
Ginkgo biloba at Amazon.com.
Calcium Intake and CVD
Risks in Older Patients With T2DM - Medscape, 10/20/14 -
"Our data indicated that 60.9% and 87.3% of our patients
were Ca and Mg intakes below RDA, respectively. Patients whose Ca intake was
high or low (81.2%) had significantly higher C-reactive protein (CRP) than those
whose Ca intake was moderate (p = 0.043). Furthermore, patients whose Mg intake
was low (87.3%) had significantly higher CRP than that of those who took
adequate Mg (p = 0.025). The dietary Ca:Mg intake ratios were highly correlated
with CRP, platelet counts, and red blood cell distribution (p < 0.05). A dietary
Ca:Mg intake ratio of 2.0–2.5 was significantly correlated to lower CRP levels
(p = 0.013)" - See
Magtein at Amazon.com.
Between Glucosamine and Chondroitin Supplement Use and Biomarkers of Systemic
Inflammation - J Altern Complement Med. 2014 Apr 16 -
"high-sensitivity C-reactive protein (hsCRP) ... urinary
prostaglandin E2-metabolite (PGE-M) ... High users (14 or more pills/week) of
chondroitin had 36% lower hsCRP (ratio, 0.64; 95% confidence interval [CI],
0.39-1.04; p for trend=.03) and 27% lower PGE-M (ratio, 0.73; 95% CI, 0.5-0.98;
p for trend=.07) than nonusers. Compared with nonusers, high users of
glucosamine had 28% lower hsCRP (ratio, 0.72; 95% CI, 0.47-1.08; p for
trend=.09) and 24% lower PGE-M (ratio, 0.76; 95% CI, 0.59-0.97; p for
trend=0.10)" - See
chondroitin sulfate at Amazon.com
glucosamine products at Amazon.com.
magnesium intake is inversely associated with serum C-reactive protein levels:
meta-analysis and systematic review - Eur J Clin Nutr. 2014 Feb 12 -
"This meta-analysis and systematic review indicates that
dietary Mg intake is significantly and inversely associated with serum CRP
levels. The potential beneficial effect of Mg intake on chronic diseases may be,
at least in part, explained by inhibiting inflammation"
Magtein at Amazon.com.
of Dietary Fiber Intake With Long-Term Predicted Cardiovascular Disease Risk and
C-Reactive Protein Levels (from the National Health and Nutrition Examination
Survey Data [2005-2010]) - Am J Cardiol. 2013 Oct 3 -
"A total of 11,113 subjects, aged 20 to 79 years with no
history of CVD, from the 2005 to 2010 National Health and Nutrition Examination
Survey were included in the present study to examine associations of dietary
fiber intake with predicted lifetime CVD risk and C-reactive protein levels.
Dietary fiber intake showed a significant gradient association with the
likelihood of having a low or an intermediate predicted lifetime CVD risk among
young and middle-age adults. In fully adjusted multinomial logistic models,
dietary fiber intake was related to a low lifetime CVD risk with an odds ratio
of 2.71 (95% confidence interval 2.05 to 3.59) in the young adults and 2.13 (95%
confidence interval 1.42 to 3.20) in the middle-age adults and was related to an
intermediate lifetime risk of 2.65 (95% confidence interval 1.79 to 3.92) in the
young and 1.98 (95% confidence interval 1.32 to 2.98) in the middle-age adults
compared with a high lifetime risk. A significant inverse linear association was
seen between dietary fiber intake and log-transformed C-reactive protein levels
with a regression coefficient +/- standard error of -0.18 +/- 0.04 in the
highest quartile of fiber intake compared with the lowest fiber intake" -
Garden of Life, RAW Fiber at Amazon.com.
Curcuminoids Effective C-Reactive Protein-Lowering Agents in Clinical Practice?
Evidence from a Meta-Analysis - Phytother Res. 2013 Aug 7 -
"Inflammation plays a pivotal role in the pathogenesis
of atherosclerosis and cardiovascular disease (CVD). In this context, C-reactive
protein (CRP) has been identified as a strong predictor and independent risk
factor of CVD. Curcuminoids are multifunctional natural product with promising
cardioprotective and anti-inflammatory properties ... PubMed/MEDLINE and SCOPUS
databases were searched ... Compared with placebo, supplementation with
curcuminoids was associated with a significant reduction in circulating CRP
levels (weighed mean difference: -6.44 mg/L; 95% CI: -10.77 - -2.11; p = 0.004).
This significant effect was maintained in subgroups of trials that used
bioavailability-improved preparations of curcuminoids and had supplementation
duration of ≥4 weeks, but not in the subgroups without these characteristics ...
effect appears to depend on the bioavailability of curcuminoids preparations and
also duration of supplementation" - See
curcumin products at Amazon.com.
Dietary Isoflavone Intake Is Associated with Decreased C-Reactive Protein
Concentrations among Healthy Premenopausal Women - J Nutr. 2013 Apr 24 -
"Between 2005 and 2007, 259 healthy, regularly
menstruating women were enrolled in the BioCycle Study, and followed for up to 2
menstrual cycles ... Diet was assessed up to 4 times per cycle by using 24-h
recalls ... Compared with the lowest quartile of total isoflavone intake, women
in the highest quartile had, on average, 27% lower serum CRP concentrations"
supplementation reduces plasma lipid peroxidation and C-reactive protein in
healthy nonsmokers - Atherosclerosis. 2013 Jan 29 -
"117 eligible subjects were randomly assigned to receive 10 or 20 mg/d of lutein
or placebo for 12 weeks ... total antioxidant capacity (TAOC) ... A significant
reduction was found in malondialdehyde in the 20 mg lutein group. CRP
concentration decreased in a dose-dependent manner for lutein supplementation,
and there was a significant between-group difference in CRP between the 20 mg
lutein and the placebo group. Serum CRP was directly related to the change in
plasma lutein and TAOC for both active treatment groups" - See
Jarrow Formulas, CarotenALL at Amazon.com.
use of Specialty Dietary Supplements and C-Reactive Protein Concentrations -
Medscape, 12/28/12 - "In summary, this study adds
support to laboratory research and to some human studies which suggest that
glucosamine, chondroitin, and fish oil may reduce systemic inflammation. In
doing so, this study adds biologic plausibility to previous studies which have
shown beneficial effects of these supplements on chronic diseases. Given the
number of diseases with which inflammation is associated, such as cancer and
cardiovascular disease, there is a need to find safe and effective ways to
reduce inflammation. Research suggests that these 3 supplements have excellent
safety profiles, [88–92] supporting their potential role in disease prevention"
glucosamine products at Amazon.com,
chondroitin sulfate at Amazon.com,
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
Chondroitin, Fish Oil May Reduce Inflammation - Medscape, 11/27/12 -
"Inflammation is now recognized as a factor in cancer
and cardiovascular disease as well as many rheumatoid diseases ... the
researchers found hs-CRP reductions of 17% (95% confidence interval [CI], 7% -
26%) with glucosamine, 22% (95% CI, 8% - 33%) with chondroitin, and 16% (95% CI,
0.3% - 29%) with fish oil compared with participants who did not take the
Consumption of a Grape Nutraceutical Containing Resveratrol Improves the
Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of
Cardiovascular Disease - Am J Cardiol. 2012 Apr 19 -
"In contrast to placebo and conventional grape supplement, the resveratrol-rich
grape supplement significantly decreased high-sensitivity C-reactive protein
(-26%, p = 0.03), tumor necrosis factor-α (-19.8%, p = 0.01), plasminogen
activator inhibitor type 1 (-16.8%, p = 0.03), and interleukin-6/interleukin-10
ratio (-24%, p = 0.04) and increased anti-inflammatory interleukin-10 (19.8%, p
= 0.00). Adiponectin (6.5%, p = 0.07) and soluble intercellular adhesion
molecule-1 (-5.7%, p = 0.06) tended to increase and decrease, respectively. No
adverse effects were observed in any patient. In conclusion, 1-year consumption
of a resveratrol-rich grape supplement improved the inflammatory and
fibrinolytic status in patients who were on statins for primary prevention of
CVD and at high CVD risk (i.e., with diabetes or hypercholesterolemia plus ≥1
other CV risk factor). Our results show for the first time that a dietary
intervention with grape resveratrol could complement the gold standard therapy
in the primary prevention of CVD" - See
resveratrol products at Amazon.com.
Supplement Alters Markers of Inflammatory and Nutritional Status in Colorectal
Cancer Patients - Nutr Cancer. 2012 Feb 1 - "The
supplemented group (SG) consumed 2 g of fish oil containing 600 milligrams of
eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) for 9 wk ... Patients
supplemented with fish oil (SG) showed a clinically relevant decrease in the
C-reactive protein/albumin relation (P = 0.005). Low doses of fish oil
supplement can positively modulate the nutritional status and the C-reative
protein/albumin ratio" - See
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
rich in slowly digested carbs reduces markers of inflammation in overweight and
obese adults - Science Daily, 1/11/12 - "Among
overweight and obese adults, a diet rich in slowly digested carbohydrates, such
as whole grains, legumes and other high-fiber foods, significantly reduces
markers of inflammation associated with chronic disease ... a low-glycemic-load
diet reduced a biomarker of inflammation called C-reactive protein by about 22
percent ... C-reactive protein is associated with an increased risk for many
cancers as well as cardiovascular disease ... a low-glycemic-load diet modestly
increased -- by about 5 percent -- blood levels of a protein hormone called
adiponectin ... a low-glycemic-load diet modestly increased -- by about 5
percent -- blood levels of a protein hormone called adiponectin. This hormone
plays a key role in protecting against several cancers, including breast cancer,
as well as metabolic disorders such as type-2 diabetes, nonalcoholic fatty liver
disease and hardening of the arteries"
Omega-3 again linked to lower inflammation: Study - Nutra USA, 11/28/11 -
"the researchers analyzed blood levels of omega-3 fatty
acids, CRP, as well as methylmercury levels in the hair of Finnish men aged
between 42 and 60 ... Results showed that as omega-3 levels increased, CRP
levels decreased, with “statistically significant inverse associations were also
observed with the total serum long-chain n-3 PUFA concentration and with the
individual long-chain n-3 PUFAs docosapentaenoic acid and docosahexaenoic acid,
but not with eicosapentaenoic acid or with the intermediate-chain n-3 PUFA
alpha-linolenic acid” ... the anti-inflammatory properties of omega-3 may be
linked to the compounds' unsaturated double bonds" - [Abstract]
Jarrow Max DHA at Amazon.com.
Omega-3 Fatty Acid, Ratio of Omega-6 to Omega-3 Intake, Inflammation, and
Survival in Long-term Hemodialysis Patients - Am J Kidney Dis. 2011 Jun 7 -
"each 1-unit higher ratio of omega-6 to omega-3 intake
was associated with a 0.55-mg/L increase in serum CRP level (P = 0.03). In the
fully adjusted model, death HRs for the first (1.7-<7.6), second (7.6-<9.3),
third (9.3-<11.3), and fourth (11.3-17.4) quartiles of dietary omega-6 to
omega-3 ratio were 0.39 (95% CI, 0.14-1.18), 0.30 (95% CI, 0.09-0.99), 0.67 (95%
CI, 0.25-1.79), and 1.00 (reference), respectively (P for trend = 0.06) ...
Higher dietary omega-6 to omega-3 ratio appears to be associated with both
worsening inflammation over time and a trend toward higher death risk in
Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of
quercetin in human in vitro and in vivo models - Atherosclerosis. 2011 May 5
- "In cultured human endothelial cells, quercetin
protected against H(2)O(2)-induced lipid peroxidation and reduced the
cytokine-induced cell-surface expression of VCAM-1 and E-selectin. Quercetin
also reduced the transcriptional activity of NFκB in human hepatocytes. In human
CRP transgenic mice (quercetin plasma concentration: 12.9+/-1.3μM), quercetin
quenched IL1β-induced CRP expression, as did sodium salicylate. In ApoE*3Leiden
mice, quercetin (plasma concentration: 19.3+/-8.3μM) significantly attenuated
atherosclerosis by 40% (sodium salicylate by 86%). Quercetin did not affect
atherogenic plasma lipids or lipoproteins but it significantly lowered the
circulating inflammatory risk factors SAA and fibrinogen. Combined histological
and microarray analysis of aortas revealed that quercetin affected vascular cell
proliferation thereby reducing atherosclerotic lesion growth. Quercetin also
reduced the gene expression of specific factors implicated in local vascular
inflammation including IL-1R, Ccl8, IKK, and STAT3 ...Quercetin reduces the
expression of human CRP and cardiovascular risk factors (SAA, fibrinogen) in
mice in vivo. These systemic effects together with local anti-proliferative and
anti-inflammatory effects in the aorta may contribute to the attenuation of
atherosclerosis" - See
quercetin at Amazon.com.
Supplementation of Grape Skin Extract Improves Glycemia and Inflammation in
Diet-Induced Obese Mice Fed a Western High Fat Diet - J Agric Food Chem.
2011 Mar 9 - "Dietary antioxidants may provide a
cost-effective strategy to promote health in obesity by targeting oxidative
stress and inflammation. We recently found that the antioxidant-rich grape skin
extract (GSE) also exerts a novel anti-hyperglycemic activity. This study
investigated whether 3-month GSE supplementation can improve oxidative stress,
inflammation, and hyperglycemia associated with a Western diet-induced obesity.
Young diet-induced obese (DIO) mice were randomly divided to three treatment
groups (n = 12): a standard diet (S group), a Western high fat diet (W group),
and the Western diet plus GSE (2.4 g GSE/kg diet, WGSE group). By week 12, DIO
mice in the WGSE group gained significantly more weight (24.6 g) than the W
(20.2 g) and S groups (11.2 g); the high fat diet groups gained 80% more weight
than the standard diet group. Eight of 12 mice in the W group, compared to only
1 of 12 mice in the WGSE group, had fasting blood glucose levels above 140
mg/dL. Mice in the WGSE group also had 21% lower fasting blood glucose and 17.1%
lower C-reactive protein levels than mice in the W group (P < 0.05). However,
the GSE supplementation did not affect oxidative stress in diet-induced obesity
as determined by plasma oxygen radical absorbance capacity, glutathione
peroxidase, and liver lipid peroxidation. Collectively, the results indicated a
beneficial role of GSE supplementation for improving glycemic control and
inflammation in diet-induced obesity" - See
grape seed extract at Amazon.com.
Are Associated with Serum Concentrations of High Sensitivity C-Reactive Protein
among Premenopausal Women - J Nutr. 2010 Jul 28 -
"Whole grain intake was inversely associated with hs-CRP concentrations after
adjusting for age, race, BMI, illness, and antiinflammatory drug use. Consumers
of between 0 and 1 serving/d of whole grains had, on average, 11.5% lower hs-CRP
concentrations (P = 0.02) and consumers of >/=1 serving/d had 12.3% lower hs-CRP
concentrations (P = 0.02) compared with nonconsumers"
Brushing Teeth May Keep Away Heart Disease - WebMD, 5/27/10 -
"people who admitted to brushing their teeth less
frequently had a 70% extra risk of heart disease ... People who reported poor
oral hygiene also tested positive for bloodstream inflammatory markers such as
fibrinogen and C-reactive protein"
decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in
elderly subjects: a potential implication of zinc as an atheroprotective agent
- Am J Clin Nutr. 2010 Apr 28 - "One group was given an
oral dose of 45 mg zinc/d as a gluconate for 6 mo ... These findings suggest
that zinc may have a protective effect in atherosclerosis because of its
antiinflammatory and antioxidant functions" - See
Jarrow Zinc Balance at Amazon.com
(zinc decreases copper).
Kidney flow and function in hypertension: protective effects of pycnogenol in
hypertensive participants--a controlled study - J Cardiovasc Pharmacol Ther.
2010 Mar;15(1):41-6 - "evaluated the effects of
Pycnogenol as an adjunct to angiotensin-converting enzyme (ACE)-inhibitor
ramipril treatment of hypertensive patients presenting with early signs of renal
function problems. One group of 26 patients was medicated with 10 mg ramipril
per day only; a second group of 29 patients took Pycnogenol in addition to the
ACE inhibitor over a period of 6 months ... In both groups, CRP levels decreased
from 2.1 to 1.8 with ramipril and from 2.2 to 1.1 with the ramipril-Pycnogenol
combination; the latter reached statistical significance" - See
Pycnogenol at Amazon.com.
vitamin C concentration and hs-CRP level in middle-aged Japanese men and
women - Atherosclerosis. 2009 Aug 7 - "Inverse
associations between serum vitamin C concentrations and hs-CRP levels were
established for both men and women. Multivariable-adjusted mean values of
hs-CRP for the lowest to highest quintiles of vitamin C levels were 0.75,
0.65, 0.61, 0.61 and 0.47mg/L (P for trend <0.001) for men, and 0.56, 0.51,
0.49, 0.41 and 0.41mg/L (P for trend <0.001) for women. The inverse
association between vitamin C and hs-CRP was stronger for non-smoking men
and women, non-overweight women and postmenopausal women ... Serum vitamin C
concentrations were found to be inversely associated with hs-CRP levels in
both men and women, primarily among non-smokers, non-overweight women and
fatty acid supplements improve the cardiovascular risk profile of subjects
with metabolic syndrome, including markers of inflammation and auto-immunity
- Acta Cardiol. 2009 Jun;64(3):321-7 - "were given 1
gram of fish oil as a single capsule, containing 180 mg eicosapentaenoic
acid and 120 mg docosahexaenoic acid daily for 6 months. Control subjects
did not receive any supplementation over the same period. RESULTS: The study
was completed by 47 subjects in the intervention group and 42 subjects in
the control group. Treatment with omega 3 supplements was associated with a
significant fall in body weight (P < 0.05), systolic blood pressures (P <
0.05), serum low density lipoprotein cholesterol (P < 0.05), and total
cholesterol (P < 0.05), triglycerides (P < 0.05), high-sensitivity
C-reactive protein (hs-CRP) (P < 0.01), and Hsp27 antibody titres (P <
0.05). No significant changes were observed in the control group.
CONCLUSION: It appears that omega 3 improves the cardiovascular risk profile
of subjects with metabolic syndrome, having effects on weight, systolic
blood pressure, lipid profile and markers of inflammation and autoimmunity"
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
inverse relationship between plasma n-3 fatty acids and C-reactive protein
in healthy individuals - Eur J Clin Nutr. 2009 Apr 8 -
"The highest hs-CRP tertile (>3.0 mg/l) had
significantly lower concentrations of total n-3 fatty acids, EPA and DPA,
when compared with the other tertiles (P<0.05). This study provides evidence
that in healthy individuals, plasma n-3 fatty acid concentration is
inversely related to hs-CRP concentration, a surrogate marker of CVD risk"
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
Omega-3 DHA boost for heart health in high-risk men: Study - Nutra USA,
3/6/09 - "supplementation with DHA for 45 days
resulted in decreased levels of the number of circulating white blood cells
(neutrophils) by 11.7 per cent, and these reductions were maintained until
the end of the 90-day study (10.5 per cent reduction) ... levels of
C-reactive protein (CRP) had decreased by 15 per cent, and IL-6 had
decreased by 23 per cent ... Furthermore, levels of the anti-inflammatory
matrix metalloproteinase-2 rose by 7 per cent ... In conclusion, DHA may
lessen the inflammatory response by altering blood lipids and their fatty
acid composition" - [Abstract]
Jarrow Max DHA at Amazon.com.
Supplementation Decreases Serum C-Reactive Protein and Other Markers of
Inflammation in Hypertriglyceridemic Men - J Nutr. 2009 Jan 21 -
"DHA supplementation for 45 and 91 d decreased the
number of circulating neutrophils by 11.7 and 10.5%, respectively (P <
0.05). It did not alter the circulating concentrations of other inflammatory
markers tested within 45 d, but at 91 d it reduced (P < 0.05) concentrations
of C-reactive protein (CRP) by 15%, interleukin-6 by 23%, and granulocyte
monocyte-colony stimulating factor by 21% and DHA increased the
concentration of antiinflammatory matrix metalloproteinase-2 by 7%. The
number of circulating neutrophils was positively associated with the weight
percent (wt %) of 20:4(n-6) in RBC lipids, and negatively to the wt % of
20:5(n-3) and 22:6(n-3). Concentrations of CRP and serum amyloid A were
positively associated with the sum of SFA and negatively with the wt % of
18:1(n-9) and 17:0 in RBC lipids; CRP was also positively associated with
the wt % of 20:2(n-6). The mean size of VLDL particles was positively
associated with plasma concentrations of neutrophils and CRP. In conclusion,
DHA may lessen the inflammatory response by altering blood lipids and their
fatty acid composition" - See
Jarrow Max DHA at Amazon.com.
Inflamed Gums Linked To Heart Disease - Science Daily, 12/20/08 -
"a protein associated with inflammation (called CRP)
is elevated in people who are at risk for heart disease. But where's the
inflammation coming from? ... infected gums may be one place ... something
as simple as taking good care of your teeth and gums can greatly reduce your
risk of developing serious diseases"
Pine bark extract may help joints and hearts: Study - Nutra USA,
12/11/08 - "The decrease of systemic inflammatory
markers, particularly CRP, suggests Pycnogenol properties may be potent
enough to arrest the spread of inflammation from osteoarthritic joints to
the whole organisms ... subjects received either two daily doses of 50 mg
Pycnogenol or placebo for three months ... people receiving the pine bark
extract experienced significant reductions in CRP levels from an average of
3.9 mg/L at the start of the study to 1.1 mg/L after three months. This is
equivalent to a 71 per cent reduction ... Moreover, a reduction in the blood
levels of reactive oxygen species (ROS) of 30 per cent was recorded"
Pycnogenol at Amazon.com.
Vitamin C Lowers Levels Of Inflammation Biomarker Considered Predictor Of
Heart Disease - Science Daily, 11/14/08 - "for
people with elevated CRP levels, the amount of CRP reduction achieved by
taking vitamin C supplements in this study is comparable to that in many
other studies of cholesterol-lowering drugs called statins. They noted that
several larger statin trials lowered CRP levels by about 0.2 milligrams per
liter; in this latest study, vitamin C lowered CRP by 0.25 milligrams per
liter" - See
vitamin C products at Amazon.com.
C-lipid metabolites: Uptake and retention and effect on plasma C-reactive
protein and oxidized LDL levels in healthy volunteers - Med Sci Monit.
2008 Nov;14(11):CR547-551 - "ascorbic acid (AA),
calcium ascorbate (CaA) ... PureWay-C(R) supplementation leads to the
highest absolute serum vitamin C levels when compared to AA, CaA and
Ester-C(R). PureWay-C(R) provides a statistically significant greater serum
level than calcium ascorbate at 1, 2, 4, and 6 hours post oral
supplementation whereas Ester-C(R) shows a less but slightly statistically
significant increase at only 1 and 4 hours. Oral supplementation with
PureWay-C(R) also led to a greater reduction in plasma C-reactive protein
and oxidized LDL levels compared to the other vitamin C formulations.
Conclusions: PureWay-C(R) is more rapidly absorbed and leads to higher serum
vitamin C levels and greater reduction of plasma levels of inflammatory and
oxidative stress markers than other forms of vitamin C, including
Ester-C(R)" - See
vitamin C products at Amazon.com.
Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty
acids and plant sterols in hyperlipidemic individuals - Atherosclerosis.
2008 Sep 27 - "The combination of n-3 PUFA and plant
sterols reduced several inflammatory markers. High sensitivity C-reactive
protein (hs-CRP) was reduced by 39% (P=0.009), tumor necrosis factor-alpha
(TNF-alpha) by 10% (P=0.02), interleukin-6 (IL-6) by 10.7% (P=0.009),
leukotriene B(4) (LTB(4)) by 29.5% (P=0.01) and adiponectin was increased by
29.5% (P=0.05). Overall cardiovascular risk was reduced by 22.6% (P=0.006)
in the combination group. CONCLUSION: We have demonstrated, for the first
time that dietary intervention with n-3 PUFA and plant sterols reduces
systemic inflammation in hyperlipidemic individuals. Furthermore, our
results suggest that reducing inflammation provides a potential mechanism by
which the combination of n-3 PUFA and plant sterols are cardioprotective"
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
Else May Probiotics Do In Adults? - Science Daily, 5/20/08 -
"It was found that probiotics have an
anti-inflammatory potential seen as a decrease in serum CRP levels and as a
reduction in bacteria-induced production of proinflammatory cytokines in
peripheral blood mononuclear cells"
Whole Grains Shrink Belly Fat? - Dr. Weil, 3/31/08 -
"the whole grains may have helped by stabilizing the
dieters' blood sugar, which in turn may have had a beneficial effect on CRP
Serum C-reactive protein concentrations are inversely associated with
dietary flavonoid intake in u.s. Adults - J Nutr. 2008 Apr;138(4):753-60
- "Among the flavonoid compounds investigated,
quercetin, kaempferol, malvidin, peonidin, daidzein, and genistein had
inverse associations with serum CRP concentration"
Dietary intake of n-3 polyunsaturated fatty acids is inversely associated
with CRP levels, especially among male smokers - Atherosclerosis. 2008
Mar 14 - "Sufficient dietary intake of n-3PUFA may
attenuate inflammatory reaction and this effect is more evident among
high-risk populations such as male smokers although the small numbers of
female ex-smokers and nonsmokers limited statistical power to draw strong
conclusions about these groups" - See
Mega Twin EPA at Amazon.com.
Dietary choline and betaine intakes in relation to concentrations of
inflammatory markers in healthy adults: the ATTICA study - Am J Clin
Nutr. 2008 Feb;87(2):424-30 - "Compared with the
lowest tertile of choline intake (<250 mg/d), participants who consumed >310
mg/d had, on average, 22% lower concentrations of C-reactive protein (P <
0.05), 26% lower concentrations of interleukin-6 (P < 0.05), and 6% lower
concentrations of tumor necrosis factor-alpha" - See
citicholine at Amazon.com.
The effects of a whole grain enriched hypocaloric diet on cardiovascular
disease risk factors in men and women with metabolic syndrome - J Clin
Nutr. 2008 Jan;87(1):79-90 - "Both hypocaloric diets
were effective means of improving CVD risk factors with moderate weight
loss. There were significantly (P < 0.05) greater decreases in CRP and
percentage body fat in the abdominal region in participants consuming whole
grains than in those consuming refined grains"
More support for whole grains for healthy hearts - Nutra USA< 1/7/08 -
"25 women and 25 men (average age 46, average BMI
35.8 kg per sq. m) were assigned to consume a reduced calorie diet (reduced
by 500 kcal/d) with half of the subjects then randomly assigned to obtain
all of their grain servings from whole grains or to avoid wholegrain foods
for 12 weeks ... CRP levels fell by 38 per cent in the whole-grain"
The effects of extended-release niacin on carotid intimal media thickness,
endothelial function and inflammatory markers in patients with the metabolic
syndrome - Int J Clin Pract. 2007 Nov;61(11):1942-8 - "After
52 weeks of treatment, there was a change of carotid IMT of +0.009 +/- 0.003
mm in the placebo group and -0.005 +/- 0.002 mm in the niacin group (p =
0.021 between groups). Endothelial function improved by 22% in the group
treated with niacin (p < 0.001), whereas no significant changes were seen in
the placebo group. High sensitivity C-reactive protein decreased by 20% in
the group treated with niacin for 52 weeks (p = 0.013). Niacin increased
HDL-C (p < 0.001) and decreased low-density lipoprotein cholesterol and
triglycerides (p < 0.001) significantly, and there were no adverse effects
on fasting glucose levels after 52 weeks of treatment" - See
niacin at Amazon.com
niacin at Amazon.com.
Effects of folic acid and vitamin B complex on serum C-reactive protein and
albumin levels in stable hemodialysis patients - Curr Med Res Opin. 2007
Jun 29 - "Folic acid and vitamin B complex
co-administration effectively lowers tHcy and hs-CRP levels and increases
albumin levels in stable hemodialysis subjects, underscoring their potential
benefit to attenuate the state of inflammation and possibly improve the
nutritional status in patients on hemodialysis"
Effect of a High-Fiber Diet vs a Fiber-Supplemented Diet on C-Reactive
Protein Level - Arch Intern Med. 2007 Mar 12;167(5):502-6 -
"Overall, the mean C-reactive protein (CRP) level
changed from 4.4 to 3.8 mg/L (-13.7%; P = .046) in the high-fiber DASH diet
group and to 3.6 mg/L (-18.1%) in the fiber-supplemented diet group ...
fiber intake of about 30 g/d) from a diet naturally rich in fiber or from a
supplement can reduce levels of CRP"
High-Fiber Diets, Fiber Supplements Reduce CRP Levels - Medscape,
"The participants were then randomized to either the
DASH (Dietary Approaches to Stop Hypertension), high-fiber diet (mean
intake, nearly 28 g of fiber per day), or to a fiber supplement (psyllium)
on top of their regular diet (mean intake, totaling 27 g/day). After 3 weeks
on one diet, participants crossed over to the other fiber diet ... Overall,
the mean CRP level changed from 4.4 to 3.8 mg/L (-13.7%; P = .046) in the
high-fiber DASH diet group and to 3.6 mg/L (-18.1%) in the
fiber-supplemented diet group (P = .02)"
Dietary long-chain n-3 fatty acids of marine origin and serum C-reactive
protein concentrations are associated in a population with a diet rich in
marine products - Am J Clin Nutr. 2006 Jul;84(1):223-9 -
"Greater intake of n-3 PUFAs derived from marine
products, as measured with a self-administered questionnaire, was
independently related to a lower prevalence of high CRP concentrations in
this older Japanese population with a diet rich in marine products. Our
findings suggest that even very high intakes of n-3 PUFAs may lower serum
Fiber Good, and Not Just for Your Gut - WebMD, 4/13/06 -
"Compared with those who ate the least fiber, those
who ate the most were 63% less likely to have high levels of C-reactive
Vitamin C could reduce inflammation - Nutra USA, 3/8/06 -
"High blood levels of vitamin C were associated with
a 45 per cent reduced risk of inflammation (with respect to CRP levels)"
Fish Help the Heart by Fighting Inflammation - WebMD, 7/5/05 -
"compared with those who said they didn't eat fish,
those who ate at least 10.5 ounces of fish per week had 33% lower C-reactive
protein and 33% lower tumor necrosis factor-alpha (another indicator of
inflammation) levels as well as much lower levels of other signs of
Total antioxidant capacity of the diet is inversely and independently
related to plasma concentration of high-sensitivity C-reactive protein in
adult Italian subjects - Br J Nutr. 2005 May;93(5):619-25 -
"dietary TAC is inversely and independently
correlated with plasma concentrations of hs-CRP and this could be one of the
mechanisms explaining the protective effects against CVD of antioxidant-rich
foods such as fruits, whole cereals and red wine"
- Study links good carbs to
healthier hearts - MSNBC, 5/2/05 -
"the CRP levels of women whose diets consisted
primarily of refined grains were 10 percent higher than women who consumed a
lot of good carbs such as fiber-rich whole grains, fruits and vegetables"
Exercise May Reduce Metabolic Syndrome Risks - WebMD, 11/15/04 -
"physical fitness was associated with lower levels
of an inflammation marker associated with heart disease, known as C-reactive
- New Research: What is
Your Optimal TSH Level? - About.com, 9/30/04 -
"normalizing the TSH with a target TSH level of less
than 2 mIU/mL is advisable to lower CRP levels and homocysteine levels, and
possibly the cholesterol levels"
- Red Wine Beats
Gin for Heart Health - WebMD, 8/13/04 -
"those who drunk red wine also had lower levels of
C-reactive protein and two other inflammatory markers"
Low plasma vitamin B-6 concentrations and modulation of coronary artery
disease risk - Am J Clin Nutr. 2004 Jun;79(6):992-8 -
"Low concentrations of pyridoxal-5'-phosphate (PLP),
the active metabolite of vitamin B-6, are associated with high C-reactive
protein (CRP) concentrations"
Vitamin C supplement to beat diabetes and heart disease - Nutra USA,
"Researchers at the University of California say
that participants who took about 500 milligrams of vitamin C supplements per
day saw a 24 per cent drop in plasma C-reactive protein (CRP) levels after
two months" - See
vitamin C products.
Reduction of C-reactive protein levels through use of a multivitamin -
Am J Med. 2003 Dec 15;115(9):702-7 -
"multivitamin use was associated with lower
C-reactive protein levels"
- Mediterranean Diet
Lowers C-reactive Protein Levels - Medscape, 11/11/03 -
"For each 10-point increase in diet score, there was
a corresponding 0.22 mg/dL reduction in C-reactive protein levels, a 0.21
pg/ml reduction in interleukin-6, a
12.5 mg/dL decrease in fibrinogen, and a 0.87 mmol/L decrease in
homocysteine levels (P < .05), he said. Also, white blood cell count
- Dietary Changes Can
Reduce Cholesterol and C-Reactive Protein as Much as Medication - New
Hope Natural Media, 9/18/03 -
"One group was treated with a
statin medication (20 mg of lovastatin per day)
and another received placebo. A third group ate a modified daily diet that
included an additional 2 grams of plant sterols provided in a margarine, 20
grams of insoluble fiber from psyllium, oats and barley, 43 grams of soy
protein from soy milk and soy meat-substitutes, and 1 ounce of whole
almonds. At the end of the study, total
cholesterol levels had decreased 6% in the placebo group, 23% in the
statin group and 22% in the modified-diet group. Levels of LDL-cholesterol
dropped 8% in the placebo group, 31% in the statin group and 29% in the
modified-diet group. CRP levels decreased 10% in the placebo group, 33% in
the statin group and 28% in the modified-diet group"
Inflammation Syndrome a Red-Hot Topic - Natural Foods Merchandiser, 9/03
"What are some of the key anti-inflammatory
supplements? ... At the top of the list are
omega-3 fish oils, gamma-linolenic acid (GLA,
an omega-6 fat that behaves more like an omega-3) and
vitamin E. Several studies have shown that natural vitamin E supplements
lower CRP levels by 30 percent to 50 percent"
- Weight Loss Eases
Harmful Inflammation - WebMD, 2/4/02 -
"They measured levels of a blood chemical called
"C-reactive protein," or CRP. This chemical goes up when inflammation in the
body rises. Then, 25 of the women were put on a weight-loss program ... On
average, CRP levels fell by 32% after a weight loss of about 33 pounds over
- Diet and Exercise Alone
Shown to Lower C-Reactive Protein - Doctor's Guide, 11/14/01 -
"Hs-CRP, a marker of low level inflammation, has
been found to be a strong predictor of myocardial infarction and stroke in
men and women, as well as subsequent clinical events in patients following
major cardiac events ... a structured program involving a low-fat,
Mediterranean diet and a supervised, three-times weekly exercise program for
three months ... Values of hs-CRP dropped 31 percent after the three months
... body fat was reduced by 5 percent ... exercise capacity improved 36
A Prescription for Alarm - Nutrition Science News, 9/01 -
"Taking natural vitamin E supplements to reduce
levels of C-reactive protein, an inflammatory compound that increases the
risk of heart disease by 4.5 times. Heart disease is increasingly viewed as
a disease of blood-vessel inflammation"
Enzymes Can Hasten Pain Relief - Nutrition Science News, 2/01 -
"Enzymes work not by
stopping or blocking inflammation, but by supporting and quickening the
process . . . By the third day after the operation, levels of C-reactive
protein—a measure of inflammation - were threefold higher in the control
High CRP Linked to
Late-Onset Schizophrenia - Medscape, 5/22/13 -
"CRP has previously been linked to increased risk for cardiovascular
disease, and more recently, in a study by these same researchers, with risk
for depression ... We had up to 19 years of follow-up, and after adjusting
for all the other factors that would also increase CRP ... we still saw
significantly increased risk of schizophrenia; for those who had even very
small elevations of CRP, they still have a 6-times increased risk for
C-Reactive Protein, Lipid-soluble Micronutrients, and Survival in Colorectal
Cancer Patients - Cancer Epidemiol Biomarkers Prev. 2013 May 15 -
"A positive association with overall risk of death
was observed for CRP (HR for highest vs. lowest quintile: 1.80; 95% CI:
1.07-3.04; Ptrend=0.01) whereas, inverse associations were generally
observed for retinol and carotenoids (HRs for overall risk of death for the
highest quintile ranging from 0.5-0.8) ... These observations are consistent
with a direct relationship between circulating CRP and overall survival
among colorectal cancer patients ... These results, if reproduced, suggest
that reduction of inflammation should be explored as a potential
complementary treatment strategy"
Linked to Depression, Psychological Distress - Medscape, 12/27/12 -
"those who had the highest levels of CRP were more
than twice as likely to have psychological distress and depression than
those with normal levels of CRP ... more research is now needed "to
establish the direction of the association between CRP and depression" —
especially because these studies were primarily cross-sectional ...
evaluated data from 73,131 adults between the ages of 20 and 100 years from
the Copenhagen General Population study and the Copenhagen City Heart study
... the age- and sex-adjusted odds ratio (OR) was 1.11 when CRP levels were
between 1.01 and 3.00 mg/L compared with the lowest levels of 0.01 to 1.00
mg/L. The ORs increased to 1.80 for CRP levels of 3.01 to 10.00 mg/L and to
2.61 for levels greater than 10.00 mg/L"
C-reactive protein levels predict breast cancer survival rates, study finds
- Science Daily, 6/1/11 - "The five-year survival
decreased from 90% for low CRP to 74% for high levels of CRP, disease-free
survival reduced from 87% to 74%, and deaths from breast cancer increased
from 11% to 20% ... The five-year survival decreased from 90% for low CRP to
74% for high levels of CRP, disease-free survival reduced from 87% to 74%,
and deaths from breast cancer increased from 11% to 20% ... While measuring
CRP levels gives a general indication of health and longevity, measuring CRP
levels for breast cancer patients seems to be an easy way to predict the
severity of the patient's disease. This may allow clinicians to alter their
treatment tactics and improve cancer survival rates"
Study links inflammation in brain to some memory decline - Science
Daily, 4/13/11 - "adults with measureable levels of
C reactive protein recalled fewer words and had smaller medial temporal
lobes ... Scientists don't know if the inflammation indicated by the C
reactive protein is the cause of the memory loss, if it reflects a response
to some other disease process or if the two factors are unrelated. But if
inflammation causes the cognitive decline, relatively simple treatments
Inflammation behind heart valve disease, research suggests - Science
Daily, 3/15/11 - "immune cells and a group of
inflammatory substances called leukotrienes can be found in calcified heart
valves. The most significant inflammation was seen in patients with the
narrowest valves on ultrasound examination. The researchers have also shown
in cell cultures that leukotrienes stimulate the calcification of heart
valve cells ... There are similarities between atherosclerosis
(calcification of the arteries) and aortic stenosis. However, lipid-lowering
medicines known as statins which are capable of preventing atherosclerosis
have proved ineffective in preventing calcification of the aortic valve ...
anti-inflammatory medication could be a future treatment for aortic
stenosis, and it would mean a lot to these patients, most of whom are
elderly, if we could slow the disease to the extent that they do not need
surgery" - See the "Alternative News" sections of my
Inflammation page and my C-Reactive
Protein page for ways to reduce it.
Sex Hormones, and Inflammatory Markers in Older Women - J Clin
Endocrinol Metab. 2011 Jan 14 - "In premenopausal
and older women, high testosterone and estradiol (E2) and low SHBG levels
are associated with insulin resistance and diabetes, conditions
characterized by low-grade inflammation ... SHBG was negatively associated
with CRP (P = 0.007), IL-6 (P = 0.008), and sIL-6r (P = 0.02). In addition,
testosterone was positively associated with CRP (P = 0.006), IL-6 (P =
0.001), and TNF-α (P = 0.0002). The negative relationship between
testosterone and sIL-6r in an age-adjusted model (P = 0.02) was no longer
significant in a fully adjusted model (P = 0.12). E2 was positively
associated with CRP (P = 0.002) but not with IL-6 in fully adjusted models.
In a final model including E2, testosterone, and SHBG, and all the
confounders previously considered, SHBG (0.23 +/- 0.08; P = 0.006) and E2
(0.21 +/- 0.08; P = 0.007), but not testosterone (P = 0.21), were still
significantly associated with CRP. Conclusion: In late postmenopausal women
not on hormone replacement therapy, SHBG and E2 are, respectively, negative
and positive, independent and significant correlates of a proinflammatory
'good' cholesterol is not always good for your health - Science Daily,
5/25/10 - "Patients in the high-risk subgroup were
characterized as having high levels of C-reactive protein (CRP), a
well-known marker of inflammation, in addition to high HDL cholesterol.
Study authors believe genetics and environmental factors, particularly
inflammation, influence whether high levels of HDL cholesterol are
protective or if they increase cardiovascular risk in individual patients.
Given an inflammatory environment, an individual's unique set of genes helps
determine whether HDL cholesterol transforms from a good actor to a bad
actor in the heart disease process"
Elevated CRP Level Linked to Decline in Executive Function and Frontal Lobe
Damage - Medscape, 4/1/10 - "They found that
higher levels of hs-CRP were associated with worse performance on tests of
executive function, even after adjustment for age, sex, education, and
cardiovascular risk factors. "It's not like these people are really
cognitively impaired," Dr. Wersching emphasized, "but it's just they do
worse than people who have a lower CRP.""
redistribution preferentially reflects the anti-inflammatory benefits of
pioglitazone treatment - Metabolism. 2010 Jan 19 -
"high-sensitivity C-reactive protein (hsCRP) ...
Pioglitazone treatment for 12 weeks decreased serum hsCRP levels (0.83
[1.14] to 0.52 [0.82] mg/L, P < .001) and improved glycemic control (fasting
glucose, P < .001; glycosylated hemoglobin, P < .001) and lipid profiles
(triglyceride, P = .016; high-density lipoprotein cholesterol, P < .001).
Between responders and nonresponders to the hsCRP-lowering effect of
pioglitazone, there were significant differences in baseline hsCRP levels
and changes in the postprandial glucose and the ratio of visceral fat
thickness (VFT) to subcutaneous fat thickness (SFT) (P = .004, .011, and
.001, respectively). The percentage change in hsCRP levels after treatment
was inversely correlated with baseline hsCRP levels (r = -0.497, P < .001)
and directly correlated with the change in postprandial glucose (r = 0.251,
P = .021), VFT (r = 0.246, P = .030), and VFT/SFT ratio (r = 0.276, P =
.015). Logistic regression analysis revealed that the hsCRP-lowering effect
of pioglitazone was affected by baseline hsCRP levels (odds ratio [OR] =
7.929, P = .007) as well as changes in postprandial 2-hour glucose (OR =
0.716, P = .025) and VFT/SFT ratio (OR = 0.055, P = .009). In conclusion,
treatment with pioglitazone produced an anti-inflammatory effect, decreasing
serum hsCRP levels; and a decrease in the VFT/SFT ratio was independently
and most strongly associated with the hsCRP-decreasing effect. These results
suggest that abdominal fat redistribution preferentially reflects the
anti-inflammatory benefits of pioglitazone treatment"
Association of sex hormones and C-reactive protein levels in men - Clin
Endocrinol (Oxf). 2009 Sep 21 - "A robust, inverse
dose-response correlation between testosterone and SHBG levels with CRP
levels provides further evidence of a potential role of androgens in
coffee consumption and CRP levels in postmenopausal overweight/obese women:
importance of hormone replacement therapy use - Eur J Clin Nutr. 2009
Sep 16 - "Plasma CRP was positively associated with
BMI (P<0.001) and negatively associated with coffee consumption (P</=0.05).
In women using HRT, plasma CRP was positively associated with BMI in women
consuming less than one cup of coffee per month (r (2)=0.15 (P<0.001)), one
cup per day (0.14 (P=0.02)) and more than one cup per day (0.12 (P=0.03)).
In women who did not use HRT, CRP was associated with BMI only in women
consuming less than one cup of coffee per day (r (2)=0.16 (P<0.001)) but not
in women consuming one cup per day (0.06 (P=0.10)) or more than one daily
cup of coffee"
Levels of Serum C-Reactive Protein Are Associated with Greater Risk of
All-Cause Mortality, but Not Dementia, in the Oldest-Old: Results from The
90+ Study - J Am Geriatr Soc. 2009 Feb 23 -
"Subjects with detectable CRP levels had significantly greater risk of
mortality (HR=1.7, 95% CI=1.0-2.9), but not dementia (HR=1.2, 95%
CI=0.6-2.1), 0.4 to 4.5 years later than subjects with undetectable CRP"
Rosuvastatin Nearly Cuts in Half Risk of Stroke - Doctor's Guide,
2/20/09 - "A refined analysis of a major clinical
trial indicates that treating patients with the cholesterol-lowering agent
rosuvastatin dramatically reduces the incidence of stroke among patients
with high levels of C-reactive protein when compared with patients taking
placebo ... Patients in the study were randomised to rosuvastatin 20 mg
daily or placebo"
More May Benefit From Cholesterol Drugs - WebMD, 1/13/09 -
"Eight out of 10 middle-aged and older Americans may
benefit from treatment with cholesterol-lowering statin drugs ... All the
participants had elevated levels of high-sensitivity C-reactive protein
(hsCRP) ... Over an average of two years of treatment, participants who took
the statin Crestor had half as many heart attacks, strokes, and deaths from
cardiovascular causes as participants randomly assigned to receive a
C-reactive protein levels and ageing male symptoms in hypogonadal men
treated with testosterone supplementation - Andrologia. 2008
Dec;40(6):398-400 - "Aging Male Symptom (AMS) ...
Testosterone administration resulted in a profound decline in CRP levels and
JUPITER hits New Orleans: Landmark study shows statins benefit healthy
individuals with high CRP levels - theheart.org, 11/9/08 -
"In a study of individuals with low LDL cholesterol
but elevated C-reactive-protein (CRP) levels, investigators showed that
rosuvastatin (Crestor, AstraZeneca) 20 mg significantly reduced the primary
end point—a composite of nonfatal MI, nonfatal stroke, hospitalization for
unstable angina, revascularization, and confirmed death from cardiovascular
causes—by 44% compared with individuals treated with placebo" -
Note: They seem to be attributing this to the reduction in CRP. At 12
months, the CRP of the 20 mg Crestor group was 2.2. The baseline was 4.2.
That's a (4.2 - 2.2)/4.2 = 47.6% reduction in CRP. Another option to reduce
CRP might be Periostat (low dose doxycycline for periodontal disease). See:
Low-dose Periostat (Doxycycline) Shows Benefits in Patients with Heart
Failure - Doctor's Guide, 11/20/02 -
"At six-month follow-up, sub-antimicrobial dose
doxycyline significantly reduced
levels by 45.8 percent compared to baseline values (p<0.05). The drug
was also associated with a 33.5 percent reduction in interleukin-6 and a
50 percent reduction in metalloproteinase ... The findings are exciting,
since research is now showing that CRP is both a key marker of
inflammation leading to future acute coronary events, but also that CRP
itself may contribute to the initiation and progression of
Levels Of C-reactive Protein In The Blood Do Not Cause Diabetes -
Science Daily, 8/11/08
Adiponectin, but not leptin or high-sensitivity C-reactive protein, is
associated with blood pressure independently of general and abdominal
adiposity - Hypertens Res. 2008 Apr;31(4):633-40 -
"all three markers were significantly correlated
with systolic blood pressure (negative correlation for adiponectin and
positive correlations for leptin and hs-CRP)"
Inflammatory Markers and Albuminuria Independently Predict Heart Failure
- Medscape, 5/2/08 - "Interleukin (IL)-6, C-reactive
protein, and macroalbuminuria are significant predictors of congestive heart
failure, independent of obesity and other established risk factors" -
Also see my inflammation page for ways to
Low Vitamin D, High CRP Linked to Poorer Function in Heart Failure Patients
- Medscape, 4/28/08 - "Lower vitamin D levels and
higher C-reactive protein levels are associated with poor aerobic capacity
and greater frailty in elderly patients with heart failure"
CRP Levels Predict Death in Patients With Chronic Heart Disease -
Medscape, 1/8/08 - "Elevated baseline CRP levels
raised the risk (per unit of log-transformed CRP level change) of the
primary endpoint by 19%, MI by 17%, total death by 19%, and cardiac death by
Comparison of Effectiveness of Rosuvastatin Versus Atorvastatin on the
Achievement of Combined C-Reactive Protein (<2 mg/L) and Low-Density
Lipoprotein Cholesterol (<70 mg/dl) Targets in Patients With Type 2 Diabetes
Mellitus (from the ANDROMEDA Study) - Am J Cardiol. 2007 Oct
15;100(8):1245-1248 - "CRP was effectively decreased
in patients with type 2 diabetes receiving rosuvastatin or atorvastatin,
whereas rosuvastatin decreased LDL cholesterol significantly more than
Inflammation Linked to Eye Disease - WebMD, 10/8/07 -
"participants with the highest CRP levels at the
study's start were 40% more likely to develop early-stage AMD during the
study, compared to those with the lowest initial CRP levels"
Human C-reactive Protein Regulates Myeloma Tumor Cell Growth And Survival
- Science Daily, 9/15/07 - "CRP protects myeloma
cells from apoptosis induced by chemotherapy drugs and stimulates myeloma
cells to secrets more IL-6, which in turn provides additional protection to
myeloma from apoptosis and stimulates liver cells to secrete more CRP. Thus,
CRP could be a therapeutic target for breaking the vicious circle of myeloma
to improve the therapeutic efficacy of currently available treatments"
The Differential Effects of Angiotensin II Type 1 Receptor Blockers on
Microalbuminuria in Relation to Low-Grade Inflammation in Metabolic
Hypertensive Patients - Am J Hypertens. 2007 May;20(5):565-72 -
"There was a significant increase in high molecular
weight adiponectin in the telmisartan group ... The reductions of
microalbuminuria and high-sensitivity C-reactive protein (hs-CRP) were
significant in the telmisartan group"
Valsartan Cuts C-Reactive Protein Levels in Prediabetics - Doctor's
Guide, 5/22/07 - "In diabetic patients with
abdominal obesity, after 16 weeks of hydrochlorothiazide therapy, median
hsCRP values were increased 16% (4.9 vs 3.7 mg/L at baseline, P <.05) but
decreased 9% in patients on valsartan (3.7 vs 4.1 mg/L at baseline, P <.05)
and 5% in patients on combination therapy"
A randomized trial of the effects of rosiglitazone and metformin on
inflammation and subclinical atherosclerosis in patients with type 2
diabetes - Am Heart J. 2007 Mar;153(3):445.e1-6 -
treatment led to similar significant improvements in glycemic control
(HbA(1c) -1.08% in the rosiglitazone group and -1.18% in the metformin
group, P = nonsignificant). High-sensitivity C-reactive protein levels
decreased by an average of 68% in the rosiglitazone group (5.99 +/- 0.88 to
1.91 +/- 0.28 mg/L, P < .001), compared with a nonsignificant 4% reduction
in hsCRP with metformin"
Anti-Inflammatory Effects of Pioglitazone and/or Simvastatin in High
Cardiovascular-Risk Patients With Elevated High Sensitivity C-Reactive
Protein: The PIOSTAT Study - Medscape, 1/9/07 -
"After 12 weeks of treatment, hs-CRP levels were
reduced from 3.64 +/-2.42 mg/l to 2.48 +/-1.77 mg/l with pioglitazone
monotherapy and from 3.26 +/-2.02 mg/l to 2.81 +/-2.11 mg/l with simvastatin
monotherapy (as illustrated in Fig. 1). Combination treatment with
pioglitazone and simvastatin resulted in an additive decrease in hs-CRP
levels from 3.49 +/-1.97 mg/l to 2.06 +/-1.42 mg/l after 12 weeks" -
See pioglitazone and simvastatin at
Markers Strongly Linked To Prostate Cancer Incidence And Mortality Almost A
Decade Prior To Diagnosis - Science Daily, 11/14/06 -
"Increased levels of two markers of inflammation,
interleukin-6 (IL-6) and C-reactive protein (CRP), are significantly
associated with prostate cancer incidence and mortality almost a decade
prior to diagnosis"
Researchers Find Added Benefit of Statins in Those at High Risk for Heart
Disease, Diabetes - Doctor's Guide, 9/13/06 -
"found marked reductions in two pivotal biomarkers
of inflammation: C-reactive protein (CRP) and interleukin-6. While these
markers are typically elevated in insulin resistance, a condition that
precedes the development of diabetes, statin therapy reduced these levels by
36% and 44%, respectively"
CRP Test: Identify
Heart Risk? - WebMD, 7/0/06
Valsartan the First Blood Pressure Medication in a Large-Scale Clinical
Trial to Lower C-Reactive Protein, an Important Marker of Inflammation -
Doctor's Guide, 5/26/06 - "The median change in
hsCRP from baseline after six weeks in the Diovan group was -0.12 mg/L
compared to +0.05 mg/L in the Diovan HCT group, representing a difference
between the treatment groups of 13.3%"
Valsartan Lowers C-reactive Protein Levels; Combination Doesn't -
Doctor's Guide, 5/19/06 -
"Paradoxically, adding a diuretic to valsartan
(Diovan) allows even more patients to reach blood pressure goals -- but
appears to raise levels of C-reactive protein ... the monotherapy patients
achieved an 8.9% reduction while the combination patients experienced a 4.4%
Rosiglitazone reduces insulin requirement and C-reactive protein levels in
type 2 diabetic patients receiving peritoneal dialysis
- Am J Kidney Dis. 2005 Oct;46(4):713-9 - "the
RSG group also had
significantly lower CRP levels than the control group (2.21 versus 8.59
First Link Found Between Obesity, Inflammation and Vascular Disease -
Doctor's Guide, 9/16/05 -
"Researchers find human fat cells produce C-reactive
protein ... aspirin and statin drugs, now commonly used to treat heart
diseases, effectively damp down production of CRP from fat cells"
Study Reaffirms Importance of C-Reactive Protein Testing in Predicting Heart
Attack Risk - Doctor's Guide, 8/17/05 -
"women with the highest levels of total cholesterol
had twice the risk of future heart disease compared to women with the lowest
levels. The research also demonstrated that women with the highest levels of
hs-CRP had a three-fold increase in risk ... increased hs-CRP levels are
associated with the development of atherosclerosis, independent of
Diabetes Drug Actos (pioglitazone HCl) Showed Anti-Inflammatory Effects in
Patients with Type 2 Diabetes in a Clinical Study - Doctor's Guide,
6/16/05 - "CRP decreased by 6.98 mg/L compared to
1.55 mg/L for placebo (p= 0.001). IL-6 decreased by 0.78 pg/mL compared to
0.22 pg/ml for placebo"
Comparison of the effects of ramipril versus telmisartan in reducing serum
levels of high-sensitivity C-reactive protein and oxidized low-density
lipoprotein cholesterol in patients with type 2 diabetes mellitus - Am J
Cardiol. 2005 Jun 1;95(11):1386-8 - "All regimens
were associated with a significant reduction of C-reactive protein and
oxidized low-density lipoprotein cholesterol serum levels"
Insulin Resistance Correlates With Rises in C-Reactive Protein -
Doctor's Guide, 5/23/05 - "As C-reactive protein
rises, so does insulin resistance ... Increased C-reactive protein levels
may also predispose to accelerated or premature atherosclerotic disease ...
Maybe someday we'll have therapy to lower C-reactive protein levels"
Intensive Lifestyle Intervention or Metformin on Inflammation and
Coagulation in Participants With Impaired Glucose Tolerance - Diabetes.
2005 May;54(5):1566-1572 - "In men, the median
changes in CRP from baseline to 1 year were -33% in the lifestyle group, -7%
in the metformin group, and +5% in the placebo group. In women, the changes
in CRP from baseline to follow-up were -29% in the lifestyle group, -14% in
the metformin group, and 0% in the placebo group"
Evolution of C-Reactive Protein as a Cardiac Risk Factor - Medscape,
Davis Researchers Discover New Link Between C-reactive Protein, And Heart
Disease And Stroke - Science Daily, 3/30/05 -
"The cells that line the arteries are able to
produce C-reactive protein ... The good news is that reducing the
concentration of C-reactive protein with targeted drugs, such as statins,
has been shown to reduce cardiovascular events"
C-reactive protein levels and outcomes after statin therapy - N Engl J
Med. 2005 Jan 6;352(1):20-8 -
"Strategies to lower cardiovascular risk with
statins should include monitoring CRP as well as cholesterol"
Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery
disease - N Engl J Med. 2005 Jan 6;352(1):29-38 -
"For patients with coronary artery disease, the
reduced rate of progression of atherosclerosis associated with intensive
statin treatment, as compared with moderate statin treatment, is
significantly related to greater reductions in the levels of both
atherogenic lipoproteins and CRP"
Reduction of Both C-Reactive Protein and Cholesterol Required to Control
Heart Disease - Doctor's Guide, 1/6/05 -
"intensive therapy with atorvastatin reduced CRP
levels 36 percent, while the more moderate pravastatin regimen reduced CRP
by 5 percent"
- Blood Test Could
Help Prevent Heart Deaths - WebMD, 1/5/05 -
"We now know that it is not just cholesterol that
drives the plaque buildup in the arteries. It is also C-reactive protein"
- Blood Test May
Predict Heart Disease - WebMD, 12/15/04 -
"Researchers at Harvard investigated the role of CRP
in association with three other markers of inflammation and found that "the
level of C-reactive protein is a significant marker of the risk of coronary
heart disease," ... blood cholesterol levels were more strongly associated
with an increased heart disease risk than CRP or other inflammatory markers"
Common Blood Test May Predict Carotid Artery Disease - Doctor's Guide,
"When the researchers adjusted for other
carotid stenosis risk factors, such as age, history of smoking,
diabetes, hypertension, and coronary artery disease, CRP was independently
associated with stenosis, while LDL was not"
Anger, Hostility And Depressive Symptoms Linked To High C-reactive Protein
Levels - Science Daily, 9/23/04
- Anger Linked
to Heart Disease - WebMD, 9/22/04 -
"healthy adults who had mild to moderate symptoms of
depression, anger, or hostility had levels of CRP, a marker of inflammation
in the blood, that were two to three times higher than those of their calmer
counterparts. And the more negative their moods, the higher their CRP levels
C-Reactive Protein Levels May Signal Fast-Moving Heart Disease - WebMD,
"Researchers found four markers of inflammation,
including C-reactive protein, neopterin, MMP-9, and sICAM, predicted rapid
artery blockage ... People who had C-reactive protein levels in the middle
range had three times the risk of progression than those with the lowest
- Is Lower
Really Better for Cholesterol? - WebMD, 9/14/04 -
"The National Cholesterol Education Program (NCEP)
reduced target LDL levels from 100 mg/dL to 70 mg/dL for those at the very
highest risk of heart disease ... high-dose
Lipitor decreased CRP by 38%, while high-dose
Zocor reduced CRP by just 17% in the current study"
Study Shows Increased Levels of Blood Markers Years Before Onset of
Rheumatoid Arthritis Symptoms - Doctor's Guide, 8/5/04 -
"RA patients had consistently higher levels of CRP
than the healthy controls throughout the 15 years preceding outward disease
Statins May Provide Anti-Inflammatory Benefit in Patients with Rheumatoid
Arthritis - Doctor's Guide, 7/5/04 -
"C-reactive protein declined by 50%"
Significant Reduction in Left Ventricular Mass Index, Reactive Oxygen
Species Formation and C-Reactive Protein With Valsartan Treatment -
Doctor's Guide, 6/18/04 -
"Despite very similar effects on BP, there was a
significantly higher reduction in LVMI with
valsartan compared with
amlodipine ... In the valsartan group, CRP levels were significantly
Repeated Treatment Of Gum Disease Reduces Levels Of Inflammatory Factors
Known To Increase Heart Disease Risk - Science Daily, 4/8/04 -
"in people who had elevated levels of CRP at
baseline, removal of dental plaque bacteria by scaling or scaling combined
with topical antibiotics produced a statistically significant reduction,
bringing CRP levels close to the low-risk level. Both treatments also
significantly reduced levels of fibrinogen in patients with elevated
- CRP Test Little
Help in Predicting Heart Risk - WebMD, 3/31/04 -
"Now a much larger study shows that these studies
overestimated the value of CRP tests .... The newer test adds little to what
doctors already know about a person's heart-disease risk from blood
cholesterol levels and smoking status"
CRP: Identifying Colon Cancer Risk - Physician's Weekly, 3/22/04 -
"the likelihood of developing colorectal cancers
increased progressively with higher concentrations of CRP"
C-Reactive Protein as Independent Predictor of Type 2 Diabetes in Women
- Doctor's Guide, 3/8/04 -
"Elevated plasma C-reactive protein (CRP), an
inflammatory biomarker, is an independent risk factor for type 2 diabetes in
females ... C-reactive protein is a sensitive and stable marker for systemic
inflammation, and may be a potential target for intervention in healthy
High C-Reactive Protein Levels Associated with Increased Risk of Age-Related
Macular Degeneration - Doctor's Guide, 2/13/04 -
"CRP levels were significantly higher among
individuals with intermediate and advanced stages of AMD compared with
Link Found Between High C-Reactive Protein Levels and Subsequent Colon
Cancer Development - Doctor's Guide, 2/3/04 -
"Elevated plasma concentrations of C-reactive protein
(CRP) appear to increase the risk of developing colon
cancer" - [WebMD]
Higher C-Reactive Protein Levels Appear Associated with Increased Risk of
Incident Hypertension - Doctor's Guide, 12/11/03
Diabetes, Are You at Risk? - Time Magazine Cover Story, 12/8/03 -
"Now there are half a dozen studies confirming that
if you measure markers of inflammation, and CRP in particular, you can do a
good job of predicting who's going to get diabetes"
Elevated Systolic Blood Pressure And C-Reactive Protein Linked In Ischemic
Stroke - Doctor's Guide, 12/1/03 -
"increase of SBP, diastolic BP (DBP), mean arterial
pressure (MAP), or pulse pressure (PP) was significantly associated with an
increased odds of elevated CRP level ... Moreover, for each 10 mm Hg
increase in SBP, DBP, MAP, or PP, the odds of having a high CRP level
increased by 72%"
Adds to Blood Pressure Risks - WebMD, 11/24/03 -
"when both blood pressure and CRP levels are
elevated, the risk of heart attack and stroke may be as much as eight times
Ezetimibe Plus Simvastatin Reduces C-Reactive Protein Levels - Doctor's
- Can C-Reactive
Protein Make You Older? - WebMD, 11/13/03 -
"Every 1 mg/L increase in C-reactive protein was
equivalent to the effect [on exercise duration] of being approximately two
years older ... At this point, we're not sure if poor fitness level causes
the increase in C-reactive protein or vice versa"
Zetia (Ezetimibe) Plus Simvastatin Provided More than Twice the Reduction of
C-reactive protein in Patients with High Cholesterol Compared to Simvastatin
Alone - Doctor's Guide, 11/13/03 - "CRP is
considered an emerging risk marker for CHD ...
simvastatin reduced levels of the marker CRP by 33.3 percent compared to
simvastatin administered alone (14.3 percent ... In addition, patients
taking Zetia co-administered with simvastatin experienced an LDL cholesterol
(LDL-C) reduction of 45 to 60 percent across the dosage range, compared to a
reduction of 31 to 44 percent in patients taking simvastatin alone"
Metformin Decreases Serum C-Reactive Protein in Women With Polycystic
Ovarian Syndrome - Doctor's Guide, 10/28/03 -
"During metformin treatment, serum CRP levels
decreased significantly at 6 months overall"
- Heart Risk
Factor Shows Up in Kids - WebMD, 8/18/03 -
"The factor is CRP -- C-reactive protein. In adults,
high CRP levels mean a person is at high risk of serious heart disease. It's
a sign that blood vessels are showing signs of inflammation ... high CRP
levels were linked to being fat but not to other heart-disease risk factors"
Glycaemic Control Important in Controlling Cardiovascular Disease, Diabetes
Risk - Doctor's Guide, 8/14/03 -
"insulin resistance in
the pre-diabetic state is associated with the presence of additional
cardiovascular risk factors and increased incidence of CVD ... chronic
sub-clinical inflammation as measured by C-reactive protein (CRP) and other
markers is associated with insulin resistance, increased risk of type 2
diabetes, and cardiovascular events ... insulin-sensitising agents such as
glitazones may be useful in decreasing sub-clinical inflammation, and statin
therapy may lower both cholesterol and CRP"
New Definition For Metabolic Syndrome Predicts Coronary Heart Disease And
Type 2 Diabetes - Doctor's Guide, 8/11/03 -
"C-reactive protein (CRP) level was significantly
elevated in those with metabolic syndrome ...
minor modifications of the current definition as achieved by adding CRP or
lowering the glucose cut-off may enhance prediction of CHD and diabetes"
Influence of depressive mood on the association of CRP and obesity in 3205
middle aged healthy men - Brain Behav Immun. 2003 Aug;17(4):268-75 -
"Stratification of the sample into three levels of
depressive mood revealed a significant association between increased CRP in
the obese sample with highest level of depression in comparison to the low
level obese depression group"
Oral but not Transdermal Estrogen Replacement Therapy may Increase CRP
Levels - Doctor's Guide, 8/11/03 -
appears to have no effect on C-reactive
protein (CRP) levels after 6 months. In contrast, oral oestrogen may
significantly increase CRP concentrations ... CRP is thought to promote the
inflammatory component of atherosclerosis, and increased levels may be a
strong predictor of cardiovascular events"
C-Reactive Protein Plus Established And Haematological Cardiovascular Risk
Factors Substantially Linked To C-Reactive Protein And Cardiovascular
Disease - Doctor's Guide, 7/10/03
- When Diet
Doesn't Lower Cholesterol - WebMD, 7/7/03 -
"Study participants whose CRP levels were originally
below average saw dramatic reductions in cholesterol after 12 weeks on the
DASH diet. Total cholesterol dropped by almost 9% and LDL, or bad
cholesterol, dropped by almost 12%. In participants with higher than average
CRP levels, total and LDL cholesterol levels dropped by just 3% each ...
This is the first study to suggest that
inflammation impacts the response to a traditional cholesterol lowering
diet ... Several recent studies have shown that people who lost weight on
high-protein, relatively high-fat diets lowered their cholesterol,
suggesting that weight loss alone, no matter how it is achieved, plays a
significant role in lowering cholesterol"
Low-dose Periostat (Doxycycline) Shows Benefits in Patients with Heart
Failure - Doctor's Guide, 11/20/02 -
"At six-month follow-up, sub-antimicrobial dose
doxycyline significantly reduced CRP levels
by 45.8 percent compared to baseline values (p<0.05). The drug was also
associated with a 33.5 percent reduction in interleukin-6 and a 50 percent
reduction in metalloproteinase ... The findings are exciting, since research
is now showing that CRP is both a key marker of inflammation leading to
future acute coronary events, but also that CRP itself may contribute to the
initiation and progression of atherosclerosis"
Effect of metformin and sulfonylurea on C-reactive protein level in
well-controlled type 2 diabetics with metabolic syndrome - Endocrine
2003 Apr;20(3):215-8 -
"CRP level was significantly lower in patients using
metformin for blood glucose control compared with those using
glibenclamide, 5.56 and 8.3 mg/L, respectively ... The data showed that
metformin decreases the level of circulating CRP, a marker of inflammation,
more than glibenclamide"
C-reactive protein is independently associated with fasting insulin in
nondiabetic women - Arterioscler Thromb Vasc Biol 2003 Apr 1;23(4):650-5
"increasing levels of CRP were associated with a
stepwise gradient in odds for elevated fasting
insulin among both lean and overweight women"
- Estrogen Patch
More Heart-Friendly Than Pills - WebMD, 4/15/03 -
"the C-reactive protein increased to an average of
almost twice their baseline levels when the women took oral estrogen
replacement, but not when they were on the
- Birth Control
Pill Linked to Heart Disease Protein - WebMD, 4/11/03 -
"young women who took birth control pills had twice
as much C-reactive protein in their blood as a similar group of women who
did not use birth control pills ... It is
possible that oral contraceptive use promotes inflammation"
Protein Linked to Stroke Risk - WebMD, 4/7/03
Ezetimibe Plus Simvastatin Reduces C-Reactive Protein in Patients with High
Cholesterol - Doctor's Guide, 4/4/03 -
"C-reactive protein is considered an emerging risk
factor and risk marker for coronary heart disease ... the levels of
C-reactive protein were about halved when the pooled
ezetimibe plus simvastatin results were
compared with simvastatin alone. The combination produced about a 34.8%
reduction compared to an 18.2% reduction if the statin was used as
Statins/Beta Blockers Impact On Certain C-Reactive Protein Levels -
Doctor's Guide, 1/29/03 -
"Some 93% of the 89 patients who did not use
beta-blockers and were in
the highest CRP category and had exercise-induced
compared with 42% among patients in the lower four categories. Similarly,
94% of the 67 patients who did not use statins
and were in the highest CRP category had exercise-induced ischaemia, compared
with 44% in the lower four categories"
- New Heart
Disease Blood Test Discouraged - WebMD, 1/27/03 -
"hs-CRP is most useful when a doctor is "sitting on
the fence" while determining the right treatment strategy for a person with
intermediate risk of heart disease. In those cases -- meaning someone who,
based on cholesterol, blood pressure, smoking history, and weight, is
believed to have about 10% to 20% increased risk for heart attack over the
next 10 years -- an elevated hs-CRP could tip the scale toward more
- Bad Boy in the
Blood: CRP - WebMD, 1/15/03 -
"CRP doesn't just mark risk. It contributes to
plaque formation in the blood-vessel wall. It promotes cholesterol uptake
... The most dazzling observation has been that in postmenopausal women,
even those with low cholesterol levels, CRP identifies a three-fold
increased risk for coronary artery
disease ... When they added CRP to these cells, they saw dramatic
effects. The cells began to secrete a substance called PAI-1. Increased
PAI-1 secretion predicts formation of blood clots and heart disease. It also
predicts diabetes and the pre-diabetes condition known as
metabolic disorder ... You can lower your CRP levels by doing the same
things you would do to lower your cholesterol levels: lose weight, eat fewer
calories and a very low fat diet, take the cholesterol-lowering drugs known
as statins, and the natural form of
Low-dose Periostat (Doxycycline) Shows Benefits in Patients with Heart
Failure - Doctor's Guide, 11/20/02 -
"At six-month follow-up, sub-antimicrobial dose
doxycyline significantly reduced CRP levels by 45.8 percent compared to
baseline values (p<0.05). The drug was also associated with a 33.5 percent
reduction in interleukin-6 and a 50 percent reduction in metalloproteinase
... The findings are exciting, since research is now showing that CRP is
both a key marker of inflammation leading to future acute coronary events,
but also that CRP itself may contribute to the initiation and progression of
Study finds alcohol may lessen inflammation - USA Today, 11/17/02 -
"alcohol exerted the
greatest benefit in those with the highest levels of a chemical called
C-reactive protein, CRP, which builds up when arteries become inflamed. Some
researchers now believe that CRP itself may be a previously unrecognized
cause of heart disease ... Although LDL has long been considered the best
measure of heart attack risk, about half of people who have heart attacks
don't have high cholesterol ... "I think this is a fundamental shift in our
thinking about (artery) disease""
C-Reactive Protein, IL-6 Levels Tied to Heart Disease in Postmenopausal
Women - Doctor's Guide, 8/28/02 -
"Baseline levels of the inflammatory biomarkers
C-reactive protein (CRP) and interleukin-6 (IL-6) are independently
associated with a two-fold increase in risk of healthy postmenopausal women
developing coronary heart disease (CHD)"
Bacteria Linked to Stroke - WebMD, 7/8/02 -
"H. pylori causes ulcers
in the stomach ... those who had suffered a
stroke from a blocked large artery had
significantly higher levels of the more potent strains of the bacteria ...
The study also found that levels of a substance known as C-reactive protein
(CRP) that indicates inflammation within the body were also higher in the
stroke groups. But patients with the potent strains of H. pylori had the
highest CRP levels ... treating patients with H. pylori infection may be an
easy way to reduce the risk of stroke"
Avandia (Rosiglitazone) Lowers Markers for Cardiovascular Inflammation in
Diabetic Patients - Doctor's Guide, 6/17/02 -
"Rosiglitazone treatment also reduced plasma MCP-1 (75 percent of the basal
level; p<0.05) and CRP (70 percent of basal; p<0.05)"
- New Test Predicts
Sudden Death Risk - WebMD, 4/15/02 -
"those who suffered sudden cardiac death had higher
levels of a substance called C-reactive protein (CRP) ... CRP is released
when blood vessels are inflamed ... the findings of this study show that the
levels of CRP in the blood are even more telling than once thought ... we
can intervene with lifestyle counseling and drugs like
statins and aspirin"
Combining Statin With Estrogen May Maximise Post-Menopausal Cardiovascular
Benefits - Doctor's Guide, 4/5/02 -
estrogen alone increased the median level of C-reactive protein from 0.27
to 0.46 mg/dL, equivalent to a 70 percent rise. On the other hand,
simvastatin decreased C-reactive protein levels from 0.29 to 0.28 mg/dL.
Oral estrogen combined with simvastatin increased C-reactive protein levels
by 29 percent from 0.28 to 0.36 mg/dL" - Note:
Red yeast rice is a non-prescription statin.
- Another Study
Suggests Inflammation May Trigger Diabetes - WebMD, 7/17/01 -
"The immune system and inflammation may be factors
causing type 2 diabetes ... women who had high levels of immune system
substances called C-reactive protein or interleukin-6, or both, in their
blood were more likely to develop type 2 diabetes ... Both C-reactive
protein, called CRP, and interleukin-6, or IL-6, are considered indicators
Cholesterol drug has wider benefit - USA Today, 6/28/01 - [in addition
to lowering cholesterol]
"Cholesterol-lowering drugs, called statins,
apparently work by reducing levels of a chemical known as C-reactive
protein. This protein causes inflammation, promotes blood clotting and
weakens fat-encased blockages inside arteries, causing them to burst"
Blood Test Could Indicate Who Might Benefit From Cholesterol-Lowering Drugs
- Intelihealth, 6/27/01 -
"Half of all heart attack patients have normal
cholesterol levels. A blood test can detect high levels of C-reactive
protein - a sign of inflammation"
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