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Home > Health Conditions > Heart Disease

Heart Disease

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  • Healthy fats help diseased heart muscle process, use fuel - Science Daily, 9/29/14 - "Oleate, a common dietary fat found in olive oil, restored proper metabolism of fuel in an animal model of heart failure ... As the heart walls grow thick, the volume of blood pumped out diminishes and can no longer supply the body with enough nutrients ... Failing hearts are also unable to properly process or store the fats they use for fuel, which are contained within tiny droplets called lipid bodies in heart muscle cells. The inability to use fats, the heart's primary fuel source, causes the muscle to become starved for energy ... When the researchers perfused failing rat hearts with oleate, "we saw an immediate improvement in how the hearts contracted and pumped blood," ... oleate also restored the activation of several genes for enzymes that metabolize fat"
  • Iron Deficiency: Emerging Therapeutic Target in Heart Failure - Medscape, 9/23/14 - "In patients with heart failure, iron deficiency is frequent but overlooked, with a prevalence of 30%–50%. Since it contributes to cardiac and peripheral muscle dysfunction, iron deficiency is associated with poorer clinical outcomes and a greater risk of death, independent of haemoglobin level" - Note the phrase "independent of haemoglobin level".  I had a doctor look at my hemoglobin and say that I didn't need a blood test for iron.  I showed him about ten studies and he ordered the test and it turned out I was right about my iron being way low.  I think it was athletes anemia.  See Iron supplements at Amazon.com.
  • Low-carbohydrate diets and cardiovascular and total mortality in Japanese: a 29-year follow-up of NIPPON DATA80 - Br J Nutr. 2014 Sep;112(6):916-24 - "low-carbohydrate diets (LCD) ... The multivariable-adjusted hazard ratio (HR) for CVD mortality using the Cox model comparing the highest v. lowest deciles of LCD score was 0.60 (95 % CI 0.38, 0.94; P trend= 0.021) for women and 0.78 (95 % CI 0.58, 1.05; P trend= 0.079) for women and men combined; the HR for total mortality was 0.74 (95 % CI 0.57, 0.95; P trend= 0.029) for women and 0.87 (95 % CI 0.74, 1.02; P trend= 0.090) for women and men combined. None of the associations was statistically significant in men"
  • Drinking tea reduces non-CV mortality by 24 percent - Science Daily, 8/31/14 - "The study included 131,401 people aged 18 to 95 years who had a health check up at the Paris IPC Preventive Medicine Center between January 2001 and December 2008. During a mean 3.5 years follow up there were 95 deaths from CV and 632 deaths from non-CV causes ... Tea drinking lowered the risk of non-CV death by 24% and the trend towards lowering CV mortality was nearly significant. When we extended our analysis to 2011 we found that tea continued to reduce overall mortality during the 6 year period" - See green tea extract at Amazon.com.
  • Effects of L-carnitine supplementation on oxidative stress and antioxidant enzymes activities in patients with coronary artery disease: a randomized, placebo-controlled trial - Nutr J. 2014 Aug 4;13(1):79 - "LC supplementation at a dose of 1000 mg/d was associated with a significant reduction in oxidative stress and an increase in antioxidant enzymes activities in CAD patients. CAD patients might benefit from using LC supplements to increase their anti-oxidation capacity" - See l-carnitine at Amazon.com.
  • Serum magnesium, phosphorus, and calcium are associated with risk of incident heart failure: the Atherosclerosis Risk in Communities (ARIC) Study - Am J Clin Nutr. 2014 Jul 16 - "A total of 14,709 African Americans (27%) and whites from the ARIC cohort [aged 45-64 y at baseline (1987-1989)] were observed through 2009 ... A total of 2250 incident HF events accrued over a median follow-up of 20.6 y. Participants in the lowest (≤1.4 mEq/L) compared with the highest (≥1.8 mEq/L) category of magnesium were at greater HF risk (HR: 1.71; 95% CI: 1.46, 1.99). For phosphorus, there appeared to be a threshold whereby only those in the highest quintile were at greater HF risk [HR(Q5 vs Q1): 1.34; 95% CI: 1.16, 1.54]. Higher concentrations of calcium were also associated with greater risk of HF [HR(Q5 vs Q1): 1.24; 95% CI: 1.07, 1.43] ... Low serum magnesium and high serum phosphorus and calcium were independently associated with greater risk of incident HF in this population-based cohort" - See magnesium supplements at Amazon.com.
  • Vitamin D Promotes Vascular Regeneration - Circulation. 2014 Jul 11 - "VitD3 is a novel approach to promote vascular repair" - See vitamin D at Amazon.com.
  • Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: A systematic review and meta-analysis - Atherosclerosis. 2014 Jun 17;236(1):39-46 - "Meta-analysis demonstrated that the diagnosis of PD was associated with a mean increase in c-IMT of 0.08 mm (95% C.I. = 0.07-0.09) and a mean difference in FMD of 5.1% compared to controls (95% C.I. = 2.08-8.11%). A meta-analysis of the effects of periodontal treatment on FMD showed a mean improvement of 6.64% between test and control (95% C.I. = 2.83-10.44%)"
  • Hemoglobin a1c in nondiabetic patients: an independent predictor of coronary artery disease and its severity - Mayo Clin Proc. 2014 Jul;89(7):908-16 - "compared with patients with HbA1c levels less than 5.5%, the odds ratios of occurrence of CAD in the HbA1c quartiles of 5.5% to 5.7%, 5.8% to 6.1%, and greater than 6.1% were 1.8 (95% CI, 1.2-2.7), 3.5 (95% CI, 2.3-5.3), and 4.9 (95% CI, 3.0-8.1), respectively" - See metformin at IAS.
  • Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure - Eur Heart J. 2014 Jun 13 - "Iron is a key micronutrient for homoeostasis maintenance ... Iron deficiency defined as depleted body iron stores and unmet cellular iron requirements is common in AHF, and identifies those with the poor outcome. Its correction may be an attractive therapeutic approach" - See iron supplements at Amazon.com.
  • Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED study - Nutr Metab Cardiovasc Dis. 2014 Jan 22 - "The present work is an observational study within the PREDIMED trial. Over an average of 4.3 years of follow-up, there were 273 confirmed cases of CVD among the 7172 participants (96.3%) who completed a validated 137-item food frequency questionnaire (FFQ) at baseline ... a 46% reduction in risk of CVD risk was observed comparing Q5 vs. Q1 of total polyphenol intake (HR = 0.54; 95% confidence interval [CI] = 0.33-0.91; P-trend = 0.04). The polyphenols with the strongest inverse associations were flavanols (HR = 0.40; CI 0.23-0.72; P-trend = 0.003), lignans (HR = 0.51; CI 0.30-0.86; P-trend = 0.007), and hydroxybenzoic acids (HR = 0.47; CI 0.26-0.86; P-trend 0.02)" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • A Soda a Day Ups CVD Risk by 30%: NHANES Study - Medscape, 2/4/14 - "Yang et al inform this debate by showing that the risk of CVD mortality becomes elevated once added sugar intake surpasses 15% of daily calories—equivalent to drinking one 20-ounce Mountain Dew soda in a 2000-calorie daily diet ... The risk rises exponentially as sugar intake increases, peaking with a fourfold increased risk of CVD death for individuals who consume one-third or more of their daily calories in added sugar ... it is safest to consume less than 15% of their daily calories as added sugar"
  • Dietary Fiber Lowers Risk of CVD and CHD - Medscape, 12/27/13 - "For every 7 g of dietary fiber eaten daily—which can be achieved by eating two to four servings of fruits and vegetables, or a serving of whole grains plus a portion of beans or lentils—the risks of CVD and CHD were each lowered by 9%, according to a new meta-analysis published December 19, 2013 in BMJ" - See Garden of Life, RAW Fiber at Amazon.com.
  • Vitamin D Deficiency Linked to Fatal CVD - Medscape, 12/23/13 - "Even after adjustment for other potential confounders, including smoking and physical activity, vitamin D deficiency still conferred a significant 27% increased risk for total CVD, and a 62% increased risk for fatal CVD ... Individuals with low vitamin D levels also had a significant 36% increased risk of total CHD and a nonsignificant 33% increased risk of total stroke" - See vitamin D at Amazon.com.
  • Significance of Imbalance in the Ratio of Serum n-3 to n-6 Polyunsaturated Fatty Acids in Patients With Acute Coronary Syndrome - Am J Cardiol. 2013 Nov 7 - "We enrolled 1,119 patients who were treated and in whom serum PUFA level was evaluated in 5 divisions of cardiology in a metropolitan area in Japan ... eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA) ... According to multivariate logistic regression analysis, the group with the lowest EPA/AA (≤0.33) had a greater probability of ACS (odds ratio 3.14, 95% confidence interval 1.16 to 8.49), but this was not true for DHA/AA. In conclusion, an imbalance in the ratio of serum EPA to AA, but not in the ratio of DHA to AA, was significantly associated with ACS" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Associations of Dietary Fiber Intake With Long-Term Predicted Cardiovascular Disease Risk and C-Reactive Protein Levels (from the National Health and Nutrition Examination Survey Data [2005-2010]) - Am J Cardiol. 2013 Oct 3 - "A total of 11,113 subjects, aged 20 to 79 years with no history of CVD, from the 2005 to 2010 National Health and Nutrition Examination Survey were included in the present study to examine associations of dietary fiber intake with predicted lifetime CVD risk and C-reactive protein levels. Dietary fiber intake showed a significant gradient association with the likelihood of having a low or an intermediate predicted lifetime CVD risk among young and middle-age adults. In fully adjusted multinomial logistic models, dietary fiber intake was related to a low lifetime CVD risk with an odds ratio of 2.71 (95% confidence interval 2.05 to 3.59) in the young adults and 2.13 (95% confidence interval 1.42 to 3.20) in the middle-age adults and was related to an intermediate lifetime risk of 2.65 (95% confidence interval 1.79 to 3.92) in the young and 1.98 (95% confidence interval 1.32 to 2.98) in the middle-age adults compared with a high lifetime risk. A significant inverse linear association was seen between dietary fiber intake and log-transformed C-reactive protein levels with a regression coefficient +/- standard error of -0.18 +/- 0.04 in the highest quartile of fiber intake compared with the lowest fiber intake" - See Garden of Life, RAW Fiber at Amazon.com.
  • Oleic acid increases hepatic sex hormone binding globulin production in men - Mol Nutr Food Res. 2013 Oct 20 - "Low circulating sex hormone-binding globulin (SHBG) is an independent risk factor for cardiovascular disease ... A total of 315 men were included. In these patients, nutrition data and plasma samples for SHBG assessment were obtained. In vitro studies to examine the effects of oleic and linoleic acid on SHBG production using HepG2 cells were performed. We provided evidence that SHBG serum levels were significantly higher in subjects using olive oil for cooking in comparison with subjects using sunflower oil ... MUFA were independently associated with SHBG levels and accounted for the 20.4% of SHBG variance ... Olive oil consumption is associated with elevated SHBG serum levels"
  • Link Strengthened Between Low Fiber Intake, Increased Cardiovascular Risk - Science Daily, 10/21/13 - "shows a significant association between low dietary fiber intake and cardiometabolic risks including metabolic syndrome, cardiovascular inflammation, and obesity. Surveillance data from 23,168 subjects in the National Health and Nutrition Examination Survey (NHANES) 1999-2010 was used to examine the role dietary fiber plays in heart health ... recommended intake levels according to age and sex: 38g per day for men aged 19-50 years, 30g per day for men 50 and over, 25g for women aged 19-50 years, and 21g per day for women over 50. Using data from NHANES 1999-2010, the study reveals that the mean dietary fiber intake was only 16.2g per day across all demographics during that time period" - See Garden of Life, RAW Fiber at Amazon.com.
  • Silymarin Improves Vascular Function of Aged Ovariectomized Rats - Phytother Res. 2013 Sep 30 - "Both aging and estrogen depletion lead to endothelial dysfunction, which is the main reason of many cardiovascular diseases ... silymarin (SM) ... In spite of the presence of estrogen antagonist, immediate SM treatment restored the endothelial function and vascular tone better than estrogen replacement. Additionally, as a complementary and alternative medicine, it does not cause estrogenic side effects when taken acutely" - See silymarin at Amazon.com.
  • Eicosapentaenoic Acid (EPA) Reduces Cardiovascular Events: Relationship with the EPA/Arachidonic Acid Ratio - J Atheroscler Thromb. 2013 Sep 18 - "Fish oil contains saturated and monounsaturated fatty acids that have pharmacological effects opposite to those of ω3 fatty acids (ω3). Moreover, ω3, such as EPA and docosahexaenoic acid (DHA), do not necessarily have the same metabolic and biological actions ... Recently, the Japan EPA Lipid Intervention Study (JELIS) of hp-EPA-E established the clinical efficacy of EPA for CVD, and higher levels of blood EPA, not DHA, were found to be associated with a lower incidence of major coronary events. A significant reduction in the risk of coronary events was observed when the ratio of EPA to arachidonic acid (AA) (EPA/AA) was >0.75 ... Compared with DHA, EPA administration increases the EPA/AA ratio and the (PGI2+PGI3)/TXA2 balance to a state that inhibits the onset and/or progression of CVD" - See Mega Twin EPA at Amazon.com.
  • Flavonoid intake and risk of CVD: a systematic review and meta-analysis of prospective cohort studies - Br J Nutr. 2013 Aug 16:1-11 - "The summary RR for CVD for every 10 mg/d increment in flavonol intake was 0.95 (95 % CI 0.91, 0.99). The present systematic review suggests that the dietary intakes of six classes of flavonoids, namely flavonols, anthocyanidins, proanthocyanidins, flavones, flavanones and flavan-3-ols, significantly decrease the risk of CVD" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults - J Hypertens. 2013 Jun 5 - "We have previously demonstrated acute dose-dependent increases of flow-mediated dilatation (FMD) in the brachial artery after resveratrol consumption in mildly hypertensive, overweight/obese adults. Resveratrol supplementation has also been shown to increase cerebral blood flow acutely, without affecting cognition ... Twenty-eight obese but otherwise healthy adults (BMI: 33.3 +/- 0.6 kg/m) were randomized to take a single 75 mg capsule of trans-resveratrol (Resvida) or placebo daily for 6 weeks each in a double-blind crossover supplementation trial ... A single dose of resveratrol (75 mg) following chronic resveratrol supplementation resulted in a 35% greater acute FMD response than the equivalent placebo supplementation. These FMD improvements remained significant after adjusting for baseline FMD ... Daily resveratrol consumption was well tolerated and has the potential to maintain healthy circulatory function in obese adults" - See resveratrol products at Amazon.com and resvida at Amazon.com.
  • Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies - Am J Clin Nutr. 2013 May 29 - "systematic review and meta-analysis to investigate prospective associations of circulating and dietary magnesium with incidence of CVD, IHD, and fatal IHD ... Circulating magnesium (per 0.2 mmol/L increment) was associated with a 30% lower risk of CVD" - See magnesium supplements at Amazon.com.
  • First drug to significantly improve heart failure mortality in over a decade - Science Daily, 5/25/13 - "Coenzyme Q10 decreases all cause mortality by half ... is the first drug to improve heart failure mortality in over a decade and should be added to standard treatment ... Double blind controlled trials have shown that CoQ10 improves symptoms, functional capacity and quality of life in patients with heart failure with no side effects ... Other heart failure medications block rather than enhance cellular processes and may have side effects. Supplementation with CoQ10, which is a natural and safe substance, corrects a deficiency in the body and blocks the vicious metabolic cycle in chronic heart failure called the energy starved heart" - See Jarrow Formulas, Ubiquinol, QH-Absorb, 100 mg, 120 Softgels.
  • Mechanism for how grapes reduce heart failure associated with hypertension identified - Science Daily, 5/2/13 - "Grapes are a known natural source of antioxidants and other polyphenols ... grapes exert beneficial effects in the heart: influencing gene activities and metabolic pathways that improve the levels of glutathione, the most abundant cellular antioxidant in the heart" - See Jarrow Formulas, OPCs + 95 at Amazon.com.
  • L-Carnitine in the Secondary Prevention of Cardiovascular Disease: Systematic Review and Meta-analysis - Mayo Clin Proc. 2013 Apr 15 - "A systematic review and meta-analysis of 13 controlled trials (N=3629) was conducted to determine the effects of L-carnitine vs placebo or control on mortality, ventricular arrhythmias (VAs), angina, heart failure, and reinfarction ... Compared with placebo or control, L-carnitine is associated with a 27% reduction in all-cause mortality, a 65% reduction in VAs, and a 40% reduction in anginal symptoms in patients experiencing an acute myocardial infarction" - See GPLC at Amazon.com.
  • L-carnitine significantly improves patient outcomes following heart attack, study suggests - Science Daily, 4/12/13 - "This systematic review of the 13 controlled trials in 3,629 patients, involving 250 deaths, 220 cases of new heart failure, and 38 recurrent heart attacks, found that L-carnitine was associated with: ... Significant 27% reduction in all-cause mortality (number needed to treat 38) ... Highly significant 65% reduction in ventricular arrhythmias (number needed to treat 4) ... Significant 40% reduction in the development of angina (number needed to treat 3) ... Reduction in infarct size ... These findings may seem to contradict those reported in a study published earlier this month in Nature Medicine by Robert A. Koeth and others (link below), which demonstrated that metabolism by intestinal microbiota of dietary L-carnitine produced trimethylamine N-oxide (TMAO) and accelerated atherosclerosis in mice" - Note:  I read that Koeth study and wasn't buying it with all the previous studies I had read.  See l-carnitine at Amazon.com and acetyl l-carnitine products at Amazon.com.
  • High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women - Circulation. 2013 Jan 15 - "We followed up 93 600 women 25 to 42 years of age from the Nurses' Health Study (NHS) II who were healthy at baseline (1989) to examine the relationship between anthocyanins and other flavonoids and the risk of MI. Intake of flavonoid subclasses was calculated from validated food-frequency questionnaires ... An inverse association between higher intake of anthocyanins and risk of MI was observed (hazard ratio, 0.68; 95% confidence interval, 0.49-0.96; P=0.03, highest versus lowest quintiles) after multivariate adjustment ... Combined intake of 2 anthocyanin-rich foods, blueberries and strawberries, tended to be associated with a decreased risk of MI (hazard ratio, 0.66; 95% confidence interval, 0.40-1.08) in a comparison of those consuming >3 servings a week and those with lower intake. Intakes of other flavonoid subclasses were not significantly associated with MI risk" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Relationship of lycopene intake and consumption of tomato products to incident CVD - Br J Nutr. 2013 Jan 15:1-7 - "To address this potential misclassification, we used repeated measures of intake obtained over 10 years to characterise the relationship between lycopene intake and the incidence of CVD (n 314), CHD (n 171) and stroke (n 99) in the Framingham Offspring Study ... Using an average of three intake measures with a 9-year follow-up, lycopene intake was inversely associated with CVD incidence (HR 0.83, 95 % CI 0.70, 0.98). Using an average of two intake measures and 11 years of follow-up, lycopene intake was inversely associated with CHD incidence (HR 0.74, 95 % CI 0.58, 0.94). Lycopene intake was unrelated to stroke incidence" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Strawberries, blueberries may cut heart attack risk in women - Science Daily, 1/14/13 - "Blueberries and strawberries contain high levels of naturally occurring compounds called dietary flavonoids, also found in grapes and wine, blackberries, eggplant, and other fruits and vegetables. A specific sub-class of flavonoids, called anthocyanins, may help dilate arteries, counter the buildup of plaque and provide other cardiovascular benefits ... Nurses' Health Study II ... women completed questionnaires about their diet every four years for 18 years ... Women who ate the most blueberries and strawberries had a 32-percent reduction in their risk of heart attack compared to women who ate the berries once a month or less" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Largest Study to Date Links Low Vitamin D to CVD Risk - Medscape, 9/26/12 - "The scientists compared the 5% lowest levels of vitamin D (<5 nmol/L) with the 50% highest levels (>50 nmol/L). In Denmark--where foods are not fortified with vitamin D--it is currently recommended to have a vitamin-D status of at least 50 nmol/L, they note ... they found a stepwise increase in risk: those with the lowest levels of vitamin D had a 40% increased risk of ischemic heart disease, a 64% higher chance of an MI, a 57% increased risk of early death, and an 81% higher likelihood of fatal ischemic heart disease/MI" - See vitamin D at Amazon.com.
  • Olive oil intake and CHD in the European Prospective Investigation into Cancer and Nutrition Spanish cohort - Br J Nutr. 2012 Sep 25:1-8 - "we studied the association between olive oil and CHD in the European Prospective Investigation into Cancer and Nutrition (EPIC) Spanish cohort study. The analysis included 40,142 participants (38 % male), free of CHD events at baseline, recruited from five EPIC-Spain centres from 1992 to 1996 and followed up until 2004 ... Cox proportional regression models were used to assess the relationship between validated incident CHD events and olive oil intake (energy-adjusted quartiles and each 10 g/d per 8368 kJ (2000 kcal) increment), while adjusting for potential confounders. During a 10.4-year follow-up, 587 (79 % male) CHD events were recorded. Olive oil intake was negatively associated with CHD risk after excluding dietary mis-reporters (hazard ratio (HR) 0.93; 95 % CI 0.87, 1.00 for each 10 g/d per 8368 kJ (2000 kcal) and HR 0.78; 95 % CI 0.59, 1.03 for upper v. lower quartile). The inverse association between olive oil intake (per 10 g/d per 8368 kJ (2000 kcal)) and CHD was more pronounced in never smokers (11 % reduced CHD risk (P = 0.048)), in never/low alcohol drinkers (25 % reduced CHD risk (P < 0.001)) and in virgin olive oil consumers (14 % reduced CHD risk (P = 0.072)). In conclusion, olive oil consumption was related to a reduced risk of incident CHD events"
  • Nutraceutical pill containing berberine versus ezetimibe on plasma lipid pattern in hypercholesterolemic subjects and its additive effect in patients with familial hypercholesterolemia on stable cholesterol-lowering treatment - Lipids Health Dis. 2012 Sep 22;11(1):123 - "Although statins (STs) are drugs of first choice in hypercholesterolemic patients, especially in those at high cardiovascular risk, some of them are intolerant to STs or refuse treatment with these drugs. In view of this, we have evaluated the lipid-lowering effect of a nutraceutical pill containing berberine (BBR) and of ezetimibe, as alternative treatments, in monotherapy or in combination, in 228 subjects with primary hypercholesterolemia (HCH), with history of STs intolerance or refusing STs treatment ... In HCH subjects the nutraceutical pill resulted more effective than EZE in lowering LDL cholesterol (-31.7% vs -25.4%, P < 0.001) and better tolerated. On treatment, LDL-C level below 3.36 mmol/L (<=130 mg/dl) was observed in 28.9% of subjects treated with the nutraceutical pill and 11.8% of those treated with EZE (P <0.007). In the group treated with EZE the subjects carrying the G allele of the g.1679 C > G silent polymorphism of NPC1L1 gene showed a higher response to EZE than homozygous for the common allele (GG + CG: LDL-C -29.4+/-5.0%, CC -23.6+/-6.5%, P <0.001). Combined treatment with these drugs was as effective as STs in moderate doses (LDL cholesterol -37%, triglycerides -23%). In HeFH patients the addition of BBR resulted in LDL cholesterol reductions inversely related to those induced by the stable therapy (r = -0.617, P <0.0001), with mean 10.5% further decrease" - See berberine products at iHerb.
  • Plasma and dietary omega-3 fatty acids, fish intake, and heart failure risk in the Physicians' Health Study - Am J Clin Nutr. 2012 Sep 5 - "The mean age was 58.7 y at blood collection. In a multivariable model, plasma α-linolenic acid (ALA) was associated with a lower risk of HF in a nonlinear fashion (P-quadratic trend = 0.02), and the lowest OR was observed in quintile 4 (0.66; 95% CI: 0.47, 0.94). Plasma EPA and DHA were not associated with HF, whereas plasma docosapentaenoic acid (DPA) showed a nonlinear inverse relation with HF for quintile 2 (OR: 0.55; 95% CI: 0.39, 0.79). Dietary marine n-3 FAs showed a trend toward a lower risk of HF in quintile 4 (HR: 0.81; 95% CI: 0.64, 1.02) and a nonlinear pattern across quintiles. Fish intake was associated with a lower risk of HF, with RRs of ~0.70 for all categories of fish consumption greater than one serving per month" - Note:  alpha linolenic acid is the omega-3 in flaxseed oil.  See Jarrow Formulas, Flax Seed Oil, 32 fl oz (946 ml) or Flora, Flax-O-Mega, 180 Capsules.
  • Effects of Pycnogenol on Endothelial Function in Stable CAD - Medscape, 8/2/12 - "Recent studies suggested a blood pressure-lowering effect of Pycnogenol. In a double-blind, placebo-controlled cross-over study involving 11 patients, supplementation with Pycnogenol 200 mg q.d. significantly reduced systolic blood pressure of patients with mild-to-moderate hypertension from 139.9 +/- 3.3 to 132.7 +/- 4.18 mmHg (P < 0.05) after 8 weeks of therapy, while diastolic blood pressure remained stable (93.8 +/- 1.23 vs. 92 +/- 1.7 mmHg, P = NS) ... This study demonstrates for the first time an improvement of endothelial function after 8-week treatment with Pycnogenol at a dose of 200 mg q.d. in patients with stable CAD. Pycnogenol significantly reduced oxidative stress as assessed by plasma levels of 8-isoprostanes, but left ADMA and SDMA as well as plasma ET-1 levels unaffected" - See Pycnogenol at Amazon.com.
  • L-Carnitine prevents the development of ventricular fibrosis and heart failure with preserved ejection fraction in hypertensive heart disease - J Hypertens. 2012 Jul 12 - "Prognosis of heart failure with preserved ejection fraction (HFpEF) remains poor because of unknown pathophysiology and unestablished therapeutic strategy ... L-carnitine supplementation attenuates cardiac fibrosis by increasing prostacyclin production through arachidonic acid pathway, and may be a promising therapeutic option for HFpEF" - See l-carnitine at Amazon.com.
  • Lower DHEA in Elderly Linked to Cardiovascular Events - Medscape, 6/27/12 - "Elderly men with decreased levels of dehydroepiandrosterone (DHEA) show increased rates of major cardiovascular events, even after adjustment for other traditional cardiovascular risk factors ... The men were all were participants in the Osteoporotic Fractures in Men Sweden study, a long-term project that is evaluating risk factors for various diseases ... Those in the lowest quartile of both DHEA and DHEA-S, compared with men in quartiles 2 through 4 of both, showed a higher risk for any major cardiovascular events (HR, 1.34; 95% CI, 1.06 - 1.70), coronary heart disease (HR, 1.41; 95% CI, 1.05 - 1.89), and cerebrovascular events (HR, 1.41; 95% CI, 1.00 - 1.99)" - See DHEA at Amazon.com.
  • Glycemic load, glycemic index and risk of cardiovascular diseases: Meta-analyses of prospective studies - Atherosclerosis. 2012 Jun 6 - "Fourteen studies were identified, involving 229,213 participants and more than 11,363 cases. The pooled RRs of CVDs risk for the highest vs lowest categories of GL and GI were 1.23 (95% CI: 1.11-1.36) and 1.13 (95% CI: 1.04-1.22) respectively. Both the risk estimates of GL and GI for women (GL: RR = 1.35, 95% CI: 1.18-1.55; GI: RR = 1.19, 95% CI: 1.06-1.34) were higher than men (GL: RR = 1.10, 95% CI: 0.95-1.28; GI: RR = 1.05, 95% CI: 0.94-1.17) ... High GL and GI were associated with significant increased risk of CVDs, specifically for women"
  • Natural antioxidant can protect against cardiovascular disease - Science Daily, 6/16/12 - "The enzyme -- glutathione peroxidase, or GPx3 -- is a natural antioxidant that helps protect organisms from oxidant injury and helps the body naturally repair itself. Researchers have found that patients with high levels of good cholesterol, the GPx3 enzyme does not make a significant difference. However, those patients with low levels of good cholesterol, the GPx3 enzyme could potentially be a big benefit ... The new research, published June 16 by PLoS One, supports the view that natural antioxidants may offer the human body profound benefits ... people with high levels of the GPx3 enzyme and low levels of good cholesterol were six times less likely to develop cardiovascular disease than people with low levels of both"
    • Glutathione supplements pills benefit and side effects - raysahelian.com -  "This antioxidant, made from the combination of three amino acids cysteine, glutamate, and glycine, forms part of the powerful natural antioxidant glutathione peroxidase which is found in our cells ... Supplements that help make glutathione ... Acetylcysteine ... ALA ... Pycnogenol ... The frequent use of acetaminophen (Tylenol) depletes glutathione peroxidase levels" - See n-acetyl cysteine at Amazon.com.
  • Fish consumption, omega-3 fatty acids and risk of heart failure: A meta-analysis - Clin Nutr. 2012 Jun 6 - "Using random effect model, the pooled relative risk for heart failure comparing the highest to lowest category of fish intake was 0.85 (95% CI; 0.73-0.99), p = 0.04; corresponding value for marine omega-3 fatty acids was 0.86 (0.74-1.00), p = 0.05 ... there was no evidence for publication bias" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Serum 25-Hydroxyvitamin D Concentration and Mortality From Heart Failure and Cardiovascular Disease, and Premature Mortality from All-Cause in United States Adults - Am J Cardiol. 2012 Jun 1 - "the Third National Health and Nutrition Examination Survey, which included 13,131 participants (6,130 men, 7,001 women) ≥35 years old at baseline (1988 to 1994) and followed through December 2000 ... Multivariate-adjusted Cox model indicated that subjects with serum 25(OH)D levels <20 ng/ml had 2.06 times higher risk (95% confidence interval 1.01 to 4.25) of HF death than those with serum 25(OH)D levels ≥30 ng/ml (p <0.001). In addition, hazard ratios (95% confidence intervals) for premature death from all causes were 1.40 (1.17 to 1.68) in subjects with serum 25(OH)D levels <20 ng/ml and 1.11 (0.93 to 1.33) in those with serum 25(OH)D levels of 20 to 29 ng/ml compared to those with serum 25(OH)D levels ≥30 ng/ml (p <0.001, test for trend). In conclusion, adults with inadequate serum 25(OH)D levels have significantly higher risk of death from HF and all CVDs and all-cause premature death" - See vitamin D at Amazon.com.
  • One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease - Am J Cardiol. 2012 Apr 19 - "In contrast to placebo and conventional grape supplement, the resveratrol-rich grape supplement significantly decreased high-sensitivity C-reactive protein (-26%, p = 0.03), tumor necrosis factor-α (-19.8%, p = 0.01), plasminogen activator inhibitor type 1 (-16.8%, p = 0.03), and interleukin-6/interleukin-10 ratio (-24%, p = 0.04) and increased anti-inflammatory interleukin-10 (19.8%, p = 0.00). Adiponectin (6.5%, p = 0.07) and soluble intercellular adhesion molecule-1 (-5.7%, p = 0.06) tended to increase and decrease, respectively. No adverse effects were observed in any patient. In conclusion, 1-year consumption of a resveratrol-rich grape supplement improved the inflammatory and fibrinolytic status in patients who were on statins for primary prevention of CVD and at high CVD risk (i.e., with diabetes or hypercholesterolemia plus ≥1 other CV risk factor). Our results show for the first time that a dietary intervention with grape resveratrol could complement the gold standard therapy in the primary prevention of CVD" - See resveratrol products at Amazon.com.One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease - Am J Cardiol. 2012 Apr 19 - "In contrast to placebo and conventional grape supplement, the resveratrol-rich grape supplement significantly decreased high-sensitivity C-reactive protein (-26%, p = 0.03), tumor necrosis factor-α (-19.8%, p = 0.01), plasminogen activator inhibitor type 1 (-16.8%, p = 0.03), and interleukin-6/interleukin-10 ratio (-24%, p = 0.04) and increased anti-inflammatory interleukin-10 (19.8%, p = 0.00). Adiponectin (6.5%, p = 0.07) and soluble intercellular adhesion molecule-1 (-5.7%, p = 0.06) tended to increase and decrease, respectively. No adverse effects were observed in any patient. In conclusion, 1-year consumption of a resveratrol-rich grape supplement improved the inflammatory and fibrinolytic status in patients who were on statins for primary prevention of CVD and at high CVD risk (i.e., with diabetes or hypercholesterolemia plus ≥1 other CV risk factor). Our results show for the first time that a dietary intervention with grape resveratrol could complement the gold standard therapy in the primary prevention of CVD" - See resveratrol products at Amazon.com.
  • Low β-carotene concentrations increase the risk of cardiovascular disease mortality among Finnish men with risk factors - Nutr Metab Cardiovasc Dis. 2012 Apr 9 - "During the median 15.9-year follow-up, 122 deaths from CVDs, were identified among the cohort subjects. Low serum concentrations of β-carotene were strongly related to an increased CVD mortality risk after adjustment for confounders. For β-carotene, the hazard ratio (95% confidence interval) for the lowest versus highest quartile was 2.23 (1.26-3.93; P=0.006). However, the strongest risk of CVD mortality was observed among smokers with lowest levels of β-carotene (HR=3.15, 95%, CI: 1.19-8.33; P=0.020). Other carotenoids and the sum of carotenoids were not significantly related to increased risk of CVD mortality" - See Jarrow Formulas, CarotenALL at Amazon.com.
  • Evidence for a Protective Effect of Polyphenols-containing Foods on Cardiovascular Health - Medscape, 4/5/12 - "There is supportive clinical evidence for the beneficial effects of some flavonoids-rich foods or supplements on multiple endpoints of cardiovascular risk, the more convincing being reduction in BP and improvement in endothelial function ... In addition to their identified beneficial impact on BP and endothelial function, flavonoid-rich dietary sources might also favourably modulate arterial stiffness" - See Jarrow Formulas OPCs + 95 at Amazon.com.
  • Hot pepper compound could help hearts - Science Daily, 3/27/12 - "The team found, for instance, that capsaicin and a close chemical relative boost heart health in two ways. They lower cholesterol levels by reducing accumulation of cholesterol in the body and increasing its breakdown and excretion in the feces. They also block action of a gene that makes arteries contract, restricting the flow of blood to the heart and other organs. The blocking action allows more blood to flow through blood vessels" - See capsaicin supplements at Amazon.com.
  • Diabetes drug can prevent heart disease, new study suggests - Science Daily, 3/25/12 - "one of the most common diabetes drugs, metformin, also has a protective effect on the heart ... metformin helps increase pumping capacity, improve energy balance, reduce the accumulation of fat, and limit the loss of heart cells through programmed cell death" - See metformin at IAS.
  • Nutrient found in dark meat of poultry, some seafood, may have cardiovascular benefits - Science Daily, 3/1/12 - "funded by the American Heart Association ... The comparison revealed serum taurine was not protective of CHD overall. However, among women with high cholesterol, those with high levels of serum taurine were 60 percent less likely to develop or die from CHD in the study, compared to women with lower serum taurine levels. If future studies are able to replicate the findings, taurine supplementation or dietary recommendations may one day be considered for women with high cholesterol at risk for CHD" - See taurine at Amazon.com.
  • Associations of dietary magnesium intake with mortality from cardiovascular disease: The JACC study - Atherosclerosis. 2012 Jan 28 - "Dietary magnesium intake was assessed by a validated food frequency questionnaire administered between 1988 and 1990 ... median 14.7-year follow-up ... Dietary magnesium intake was inversely associated with mortality from hemorrhagic stroke in men and with mortality from total and ischemic strokes, coronary heart disease, heart failure and total cardiovascular disease in women. The multivariable hazard ratio (95% CI) for the highest vs. the lowest quintiles of magnesium intake after adjustment for cardiovascular risk factor and sodium intake was 0.49 (0.26-0.95), P for trend=0.074 for hemorrhagic stroke in men, 0.68 (0.48-0.96), P for trend=0.010 for total stroke, 0.47 (0.29-0.77), P for trend<0.001 for ischemic stroke, 0.50 (0.30-0.84), P for trend=0.005 for coronary heart disease, 0.50 (0.28-0.87), P for trend=0.002 for heart failure and 0.64 (0.51-0.80), P for trend<0.001 for total cardiovascular disease in women" - See Jarrow Formulas, Magnesium Optimizer Citrate, 100 Easy-Solv Tablets at iHerb.
  • Red wine polyphenols improve an established aging-related endothelial dysfunction in the mesenteric artery of middle-aged rats: Role of oxidative stress - Biochem Biophys Res Commun. 2012 Feb 13 - "The present findings indicate that aging is associated with blunted endothelium-dependent relaxations involving an increased oxidative stress, and that these responses are improved by the intake of RWPs or apocynin for 4weeks most likely by normalizing the expression of eNOS, arginase I, NADPH oxidase and angiotensin receptors" - See resveratrol products at Amazon.com and grape seed extract at Amazon.com.
  • Acetyl-l-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the l-carnitine content in the rat heart - Mech Ageing Dev. 2012 Feb 1 - "The aging heart displays a loss of bioenergetic reserve capacity partially mediated through lower fatty acid utilization. We investigated whether the age-related impairment of cardiac fatty acid catabolism occurs, at least partially, through diminished levels of l-carnitine, which would adversely affect carnitine palmitoyltransferase 1 (CPT1), the rate-limiting enzyme for fatty acyl-CoA uptake into mitochondria for β-oxidation. Old (24-28 mos) Fischer 344 rats were fed+/-acetyl-l-carnitine (ALCAR; 1.5% [w/v]) for up to four weeks prior to sacrifice and isolation of cardiac interfibrillar (IFM) and subsarcolemmal (SSM) mitochondria. IFM displayed a 28% (p<0.05) age-related loss of CPT1 activity, which correlated with a decline (41%, p<0.05) in palmitoyl-CoA-driven state 3 respiration. Interestingly, SSM had preserved enzyme function and efficiently utilized palmitate. Analysis of IFM CPT1 kinetics showed both diminished V(max) and K(m) (60% and 49% respectively, p<0.05) when palmitoyl-CoA was the substrate. However, no age-related changes in enzyme kinetics were evident with respect to l-carnitine. ALCAR supplementation restored CPT1 activity in heart IFM, but not apparently through remediation of l-carnitine levels. Rather, ALCAR influenced enzyme activity over time, potentially by modulating conditions in the aging heart that ultimately affect palmitoyl-CoA binding and CPT1 kinetics" - See propionyl-l-carnitine products at Amazon.com.
  • Effect of omega-3 fatty acids supplementation on endothelial function: A meta-analysis of randomized controlled trials - Atherosclerosis. 2012 Jan 20 - "Supplementation of omega-3 fatty acids significantly improves the endothelial function without affecting endothelium-independent dilation" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Effects of n-3 fatty acids on major cardiovascular events in statin users and non-users with a history of myocardial infarction - Eur Heart J. 2012 Feb 1 - "In statin users, an additional amount of n-3 fatty acids did not reduce cardiovascular events [HR(adj) 1.02; 95% confidence interval (CI): 0.80, 1.31; P = 0.88]. In statin non-users, however, only 9% of those who received EPA-DHA plus ALA experienced an event compared with 18% in the placebo group ... In patients with a history of MI who are not treated with statins, low-dose supplementation with n-3 fatty acids may reduce major cardiovascular events. This study suggests that statin treatment modifies the effects of n-3 fatty acids on the incidence of major cardiovascular events" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Inhibition of Na(+) -H(+) exchange as a mechanism of rapid cardioprotection by resveratrol - Br J Pharmacol. 2012 Jan 31 - "Resveratrol exerts cardioprotection by reducing ROS and preserving mitochondrial function. The PKC-α-dependent inhibition of NHE and subsequent attenuation of [Ca(2+) ](i) overload may be a cardioprotective mechanism" - See resveratrol products at Amazon.com.
  • Serum antioxidant vitamin levels in patients with coronary heart disease - Int J Vitam Nutr Res. 2011 Jul;81(4):211-7 - "Fat mass (FM) ... Based on the results of this study, we propose that high FM, low HDL-C, and low serum antioxidant vitamin levels could be important risk factors for CHD"
  • Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study - Eur Heart J. 2012 Jan 11 - "Patients received Pycnogenol (200 mg/day) for 8 weeks followed by placebo or vice versa on top of standard cardiovascular therapy ... In CAD patients, Pycnogenol treatment was associated with an improvement of FMD from 5.3 +/- 2.6 to 7.0 +/- 3.1 (P < 0.0001), while no change was observed with placebo (5.4 +/- 2.4 to 4.7 +/- 2.0; P = 0.051). This difference between study groups was significant [estimated treatment effect 2.75; 95% confidence interval (CI): 1.75, 3.75, P < 0.0001]. 15-F(2t)-Isoprostane, an index of oxidative stress, significantly decreased from 0.71 +/- 0.09 to 0.66 +/- 0.13 after Pycnogenol treatment, while no change was observed in the placebo group (mean difference 0.06 pg/mL with an associated 95% CI (0.01, 0.11), P = 0.012]. Inflammation markers, platelet adhesion, and blood pressure did not change after treatment with Pycnogenol or placebo. Conclusion This study provides the first evidence that the antioxidant Pycnogenol improves endothelial function in patients with CAD by reducing oxidative stress" - See Pycnogenol at Amazon.com.
  • Serum ferritin levels associated with increased risk for developing CHD in a low-income urban population - Public Health Nutr. 2012 Jan 10:1-8 - "For men, there was a 0.5 % increase in risk for every 10-unit rise in serum ferritin (pmol/l). Other significant predictors included increased BMI, white race, unemployment and C-reactive protein ≥9.5 mg/l. For women, there was a 5.1 % increase in risk per 10-unit rise in serum ferritin (pmol/l). Other significant predictors included increased BMI, lower education, unemployment and C-reactive protein ≥9.5 mg/l"
  • Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults - Am J Clin Nutr. 2012 Jan 4 - "Men and women with total flavonoid intakes in the top (compared with the bottom) quintile had a lower risk of fatal CVD (RR: 0.82; 95% CI: 0.73, 0.92; P-trend = 0.01). Five flavonoid classes-anthocyanidins, flavan-3-ols, flavones, flavonols, and proanthocyanidins-were individually associated with lower risk of fatal CVD (all P-trend < 0.05). In men, total flavonoid intakes were more strongly associated with stroke mortality (RR: 0.63; 95% CI: 0.44, 0.89; P-trend = 0.04) than with ischemic heart disease (RR: 0.90; 95% CI: 0.72, 1.13). Many associations appeared to be nonlinear, with lower risk at intakes above the referent category.Conclusions: Flavonoid consumption was associated with lower risk of death from CVD. Most inverse associations appeared with intermediate intakes, suggesting that even relatively small amounts of flavonoid-rich foods may be beneficial"
  • Young women may reduce heart disease risk eating fish with omega 3 fatty acids, study finds - Science Daily, 12/5/11 - "In the first population-based study in women of childbearing age, those who rarely or never ate fish had 50 percent more cardiovascular problems over eight years than those who ate fish regularly. Compared to women who ate fish high in omega-3 weekly, the risk was 90 percent higher for those who rarely or never ate fish ... Fish oil contains long chain omega-3 polyunsaturated fatty acids, which are believed to protect against heart and vascular disease. Few women in the study took fish oil supplements, so these were excluded from the analyses and the results were based on the dietary intake of omega-3 fatty acids, not intake from supplements" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Plasma retinol: A novel marker for cardiovascular disease mortality in Australian adults - Nutr Metab Cardiovasc Dis. 2011 Nov 25 - "Vitamin A affects inflammation and immune function and is thus a factor of interest in relation to cardiovascular disease (CVD). As vitamin A circulates in the plasma in the form of retinol, this study aims to describe the relationship between plasma retinol and the 5-year incidence of CVD mortality ... Community-dwelling adults (n = 441, 45% with type 2 diabetes) were recruited in Melbourne, assessed at baseline and followed for 5 years. At baseline, CVD risk factors were assessed by clinical evaluation, by personal lifestyle questionnaire and from biochemistry (plasma fasting glucose, lipids, total homocysteine, C-reactive protein, retinol and carotenoids plus the urinary albumin excretion rate over 24 h.). Dietary intake was assessed by a validated food frequency questionnaire. CVD mortality over 5-years was determined by consulting state or national registries. The majority of participants had adequate plasma retinol concentrations (≥30 μg/dL). The final Cox regression model indicated that those in the highest tertile of plasma retinol (mean +/- SD) 76 +/- 14 μg/dL) had a significantly lower risk of 5-year CVD mortality (hazard ratio 0.27 [95% confidence interval 0.11, 0.68], P = 0.005), an effect that was not readily explained in terms of traditional CVD risk factors or dietary intake"
  • Effects of coenzyme Q10 on vascular endothelial function in humans: A meta-analysis of randomized controlled trials - Atherosclerosis. 2011 Oct 25 - "Coenzyme Q10 supplementation is associated with significant improvement in endothelial function. The current study supports a role for CoQ10 supplementation in patients with endothelial dysfunction" - See ubiquinol products at Amazon.com.
  • Pomegranate Juice Lowers Cardiovascular Risk Factors - Medscape, 11/12/11 - "Hemodialysis patients were randomized to receive 100 mL of pomegranate juice (n = 66) or an equivalent-tasting placebo (n = 35) 3 times a week for 12 months ... At 12 months, all components of the lipid profile improved in the pomegranate juice group but not in the placebo group. In the juice group, there were statistically significant decreases in TGs from baseline to 12 months (P = .01), especially in patients with a baseline TG level of at least 200 mg/dL (P < .001). Over the same time period, HDL rose significantly (P = .005) in the juice group. There was no significant change in any of these parameters in the placebo group ... During the study period, there was a significant decrease in systolic blood pressure in the juice group overall (P < .006), especially in patients who had a baseline systolic pressure of at least 140 mm Hg (P < .005); this was not the case in the placebo group ... At 12 months, those in the juice group were taking significantly fewer antihypertensive drugs than those in the placebo group (P < .05). In the juice group, 22% of the subjects were taking fewer and 12.2% were taking more antihypertensive drugs; in the placebo group, 7.7% were taking fewer and 34.6% were taking more antihypertensive drugs" - See pomegranate at Amazon.com.
  • Vitamin D Deficiency and Supplementation and Relation to Cardiovascular Health - Am J Cardiol. 2011 Nov 7 - "Serum vitamin D measurements for 5 years and 8 months from a large academic institution were matched to patient demographic, physiologic, and disease variables. The vitamin D levels were analyzed as a continuous variable and as normal (≥30 ng/ml) or deficient (<30 ng/ml). Descriptive statistics, univariate analysis, multivariate analysis, survival analysis, and Cox proportional hazard modeling were performed. Of 10,899 patients, the mean age was 58 +/- 15 years, 71% were women (n = 7,758), and the average body mass index was 30 +/- 8 kg/m(2). The mean serum vitamin D level was 24.1 +/- 13.6 ng/ml. Of the 10,899 patients, 3,294 (29.7%) were in the normal vitamin D range and 7,665 (70.3%) were deficient. Vitamin D deficiency was associated with several cardiovascular-related diseases, including hypertension, coronary artery disease, cardiomyopathy, and diabetes (all p <0.05). Vitamin D deficiency was a strong independent predictor of all-cause death (odds ratios 2.64, 95% confidence interval 1.901 to 3.662, p <0.0001) after adjusting for multiple clinical variables. Vitamin D supplementation conferred substantial survival benefit (odds ratio for death 0.39, 95% confidence interval 0.277 to 0.534, p <0.0001)" - See vitamin D at Amazon.com.
  • Soy beats milk protein for cholesterol improvements: RCT - Nutra USA, 10/22/11 - "Results showed that, compared with carbohydrates, the soy protein was associated with a 3.97 mg/dl reduction in total cholesterol levels, and a 0.12 mg/dl reduction in the ratio of total:HDL cholesterol ... In addition, compared to milk protein, the soy protein was associated with a 1.54 mg/dl increase in HDL cholesterol levels and a 0.14 mg/dl decrease in the ratio of total:HDL cholesterol ... On the other hand, milk protein supplementation was significantly associated with a 1.13 mg/dL decrease in HDL levels, compared to carb supplement ... The effect of milk protein did not confer a significant favorable effect on any lipid measures compared with carbohydrate" - Note:  In addition to homemade yogurt, I been using Silk plus DHA Omega-3 on my cereal.  If you read the ingredients, it's probably not the best for you but it sure tastes good.  The soy adds variety over the milk used to make the yogurt.
  • Folate and risk of coronary heart disease: A meta-analysis of prospective studies - Nutr Metab Cardiovasc Dis. 2011 Sep 14 - "Data were independently abstracted by 2 investigators using a standardized protocol. Study-specific risk estimates were combined by using a random effects model. A total of 14 studies were included in the meta-analysis: 7 studies on dietary folate intake and 8 studies on blood folate levels. For dietary intake, the summary relative risk (RR) indicated a significant association between the highest folate intake and reduced risk of CHD (summary RR: 0.69; 95% CI: 0.60, 0.80). Furthermore, an increase in folate intake of 200 ug/day was associated with a 12% decrease in the risk of developing CHD (summary RR: 0.88; 95% CI: 0.82, 0.94). For blood folate levels, we also found a borderline inverse association of highest blood folate levels on CHD risk (summary RR: 0.74; 95% CI: 0.53, 1.02); our dose-response analysis indicated that an increment in blood folate levels of 5 mmol/l was associated with an 8% decrease in the risk of developing CHD (summary RR: 0.92; 95% CI: 0.84, 1.00)" - See folic acid products at Amazon.com.
  • Systematic review: Chocolate can reduce heart disease risk by a third - Nutra USA, 8/29/11 - "A Cambridge University-led systematic review published today in the British Medical Journal has concluded that polyphenol-rich consumption can reduce the risk of heart disease by a third ... The highest levels of chocolate consumption were associated with a 37% reduction in cardiovascular disease (relative risk 0.63 (95% confidence interval 0.44 to 0.90)) and a 29% reduction in stroke compared with the lowest levels ... These favourable effects seem mainly mediated by the high content of polyphenols present in cocoa products and probably accrued through increasing the bioavailability of nitric oxide, which subsequently might lead to improvements in endothelial function, reductions in platelet function, and additional beneficial effects on blood pressure, insulin resistance, and blood lipids ... But they noted none of the selected trials were controlled, randomised studies with six cohort studies and a cross sectional study, and therefore offered the caveat: "We expect further studies will be done to confirm or refute the results of our analyses""
  • Marine n-3 Polyunsaturated Fatty Acids in Adipose Tissue and the Risk of Acute Coronary Syndrome - Circulation. 2011 Aug 22 - "Comparing men in the highest and lowest quintiles gave a hazard ratio of 0.65 (95% confidence interval, 0.45 to 0.95) for total n-3 polyunsaturated fatty acids and 0.51 (95% confidence interval, 0.36 to 0.73) for docosahexaenoic acid. Nonfatal cases constituted >86% of cases, and the association was driven primarily by a reduction in the risk of nonfatal acute coronary syndrome. No consistent associations were found among women. Conclusion- Intake of marine n-3 polyunsaturated fatty acids may protect against acute coronary syndrome in men" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Some exercise is better than none: More is better to reduce heart disease risk - Science Daily, 8/1/11 - "150 minutes of exercise per week is beneficial, 300 minutes per week will give even more benefits ... researchers examined more than 3,000 studies of physical activity and heart disease, and included 33 of them in their analysis. Among those, nine measured leisure activity quantitatively"
  • Impact of low v. moderate intakes of long-chain n-3 fatty acids on risk of coronary heart disease - Br J Nutr. 2011 May 31:1-13 - "The objective of the present study was to determine whether the consumption of ≥ 250 v. < 250 mg of the long-chain n-3 fatty acids (n-3 LCFA) per d is associated with a reduction in the risk of fatal and non-fatal CHD in individuals with no prior history of CHD. A comprehensive and systematic review of the published scientific literature resulted in the identification of eight prospective studies (seven cohorts and one nested case-control study) that met predefined inclusion criteria. Relative to the consumption of < 250 mg n-3 LCFA per d, the consumption of ≥ 250 mg/d was associated with a significant 35.1 % reduction in the risk of sudden cardiac death and a near-significant 16.6 % reduction in the risk of total fatal coronary events, while the risk of non-fatal myocardial infarction was not significantly reduced. In several meta-analyses, which were based on US studies, risk of CHD death was found to be dose-dependently reduced by the n-3 LCFA, with further risk reductions observed with intakes in excess of 250 mg/d. Prospective observational and intervention data from Japan, where intake of fish is very high, suggest that n-3 LCFA intakes of 900 to 1000 mg/d and greater may confer protection against non-fatal myocardial infarction. Thus, the intake of 250 mg n-3 LCFA per d may, indeed, be a minimum target to be achieved by the general population for the promotion of cardiovascular health" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Adherence to the Mediterranean diet reduces mortality in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain) - Br J Nutr. 2011 May 17:1-11 - "A high compared with a low rMED score was associated with a significant reduction in mortality from all causes (hazard ratio (HR) 0.79; 95 % CI 0.69, 0.91), from CVD (HR 0.66; 95 % CI 0.49, 0.89)" - Click here for my olive oil mayonnaise recipe.
  • Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trials - Am J Clin Nutr. 2011 Jun 29 - "We performed a comprehensive literature search to identify relevant trials of green tea beverages and extracts on lipid profiles in adults ... The analysis of eligible studies showed that the administration of green tea beverages or extracts resulted in significant reductions in serum TC and LDL-cholesterol concentrations, but no effect on HDL cholesterol was observed" - See green tea extract at Amazon.com.
  • Low serum magnesium concentrations predict cardiovascular and all-cause mortality - Atherosclerosis. 2011 Jun 12 - "Low serum magnesium (Mg(++)) levels are associated with future development of left ventricular hypertrophy independently of common cardiovascular risk factors, as recently demonstrated in the five-year follow-up of the population-based Study of Health in Pomerania (SHIP). As left ventricular hypertrophy has significant prognostic implications, we hypothesized that serum Mg(++) levels are associated with cardiovascular mortality ... median duration of mortality follow-up was 10.1 years ... During the follow-up, 417 deaths occurred. Mortality in subjects with Mg(++)≤0.73mmol/l was significantly higher for all-cause deaths (10.95 death per 1000 person years), and cardiovascular deaths (3.44 deaths per 1000 person years) in comparison to higher Mg(++) concentrations (1.45 deaths from all-cause per 1000 person years, 1.53 deaths from cardiovascular cause per 1000 person years). This association remained statistically significant after adjustment for multiple cardiovascular risk factors, including arterial hypertension, and antihypertensive therapy including diuretics (log-rank-test p=0.0001 for all-cause mortality, and p=0.0174 for cardiovascular mortality)" - See Jarrow Formulas, Magnesium Optimizer Citrate, 100 Easy-Solv Tablets at iHerb.
  • Vitamin E tocotrienols show cholesterol benefits for healthy adults: Study - Nutra USA, 6/29/11 - "Daily supplements of a palm oil-based tocotrienol-rich product increased the ratio of HDL cholesterol to total cholesterol – reported to be the most specific lipid risk factor for cardiovascular disease (CVD) – by 14 percent in people over 50, compared to a decrease of about 5 percent in the placebo group ... HDL cholesterol increases of the magnitude observed in this study have been associated with a 22.5 percent reduced risk of cardiovascular events" - [Abstract] - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Pine bark extract plus CoQ10 shows benefits for heart failure patients - Nutra USA, 6/23/11 - "12 weeks of daily supplementation with 350 milligrams of CoQ10 (Kaneka) and 105 milligrams of the branded pine bark extract Pycnogenol ... recruited 53 heart failure patients aged between 54 and 68 were randomly assigned to receive either the PycnoQ10 supplement or placebo for 12 weeks ... systolic and diastolic blood pressure decreased following the CoQ10-pine bark combination, from 139.2 to 133.2 mmHg and 82.3 to 77.3 mmHg, respectively. Systolic and diastolic blood pressure decreased from 140.3 to 139.5 mmHg and 83.4 to 81.2 mmHg, respectively, in the placebo group ... In addition to increases in the amount of blood pumped by the heart, the researchers also reported improvements in heart rate were also observed in the PycnoQ10 supplement group from 78.4 to 74.2 beats per minute, compared with a decrease from 79.1 to 78.4 in the placebo group" - [Abstract] - See Pycnogenol at Amazon.com and ubiquinol products at Amazon.com.
  • Impact of omega-3 polyunsaturated fatty acids on coronary plaque instability: An integrated backscatter intravascular ultrasound study - Atherosclerosis. 2011 Jun 1 - "Patients with acute coronary syndrome had significantly lower levels of ω3 PUFAs (especially of EPA and DPA) than those without it. IB-IVUS analyses showed that ω3 PUFAs correlated inversely with % lipid volume and positively with % fibrous volume. Patients with low EPA levels, low DPA levels, and low DHA levels had a significantly higher % lipid volume (p=0.048, p=0.008, and p=0.036, respectively) and a significantly lower % fibrous volume (p=0.035, p=0.008, and p=0.034, respectively) than those with high levels of these fatty acids. Even after adjustment for confounders, the presence of both low EPA and low DPA levels proved to be an independent predictor for lipid-rich plaques in any of the two categories ... A lower serum content of ω3 PUFAs (especially of EPA and DPA) was significantly associated with lipid-rich plaques, suggesting the contribution to the incidence of acute coronary syndrome" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Colours of fruit and vegetables and 10-year incidence of CHD - Br J Nutr. 2011 Jun 8:1-8 - "For each 25 g/d increase in the intake of the sum of all four colours of fruit and vegetables, a borderline significant association with incident CHD was found (HR 0.98; 95 % CI 0.97, 1.01). No clear associations were found for the colour groups separately. However, each 25 g/d increase in the intake of deep orange fruit and vegetables was inversely associated with CHD (HR 0.74; 95 % CI 0.55, 1.00). Carrots, their largest contributor (60 %), were associated with a 32 % lower risk of CHD (HR 0.68; 95 % CI 0.48, 0.98). In conclusion, though no clear associations were found for the four colour groups with CHD, a higher intake of deep orange fruit and vegetables and especially carrots may protect against CHD"
  • Associations between vitamin D and cardiovascular outcomes; Tehran Lipid and Glucose Study - Atherosclerosis. 2011 May 23 - "The mean age of participants was 56.84+/-11.17 years and 244 (48.6%) were women. The median (IQ: 25-75) of serum 25-OH-D was 14.1ng/ml (9.6-29ng/ml) and 306 (61%) of participants had serum 25-OH-D<15g/ml. Median serum 25-OH-D was lower in cases (12.5 vs. 18.1, P<0.001). After adjustment for potential confounders, the odds ratio of serum 25-OH-D<10ng/ml for having CVD outcomes was 2.90 compared with 25-OH-D≥15 (95% confidence interval" - See vitamin D at Amazon.com.
  • Dietary fiber intake and risk of cardiovascular disease in the Japanese population: the Japan Public Health Center-based study cohort - Eur J Clin Nutr. 2011 Jun 8 - "Multivariable-adjusted hazard ratios (95% confidence intervals (CIs)) of CVD for the third to fifth quintiles of total fiber were 0.79 (0.63-0.99), 0.70 (0.54-0.89) and 0.65 (0.48-0.87) in women, respectively, compared with the lowest quintile. Total fiber intake was inversely associated with the incidence of stroke, either cerebral infarction or intracerebral hemorrhage in women. The results for insoluble fiber in women were similar to those for total fiber, whereas those for soluble fiber were weak. An inverse association of total fiber with CVD was observed primarily in non-smokers (P for trend=0.045 and 0.001) and not in smokers (probability values for interaction between total fiber and smoking were 0.06 and 0.01 in men and women, respectively).Conclusions:Higher total dietary fiber was associated with reduced risk of CVD in Japanese non-smokers"
  • Vitamin D intake and risk of cardiovascular disease in US men and women - Am J Clin Nutr. 2011 Jun 8 - "After multivariate adjustment for age and other CVD risk factors, a higher total vitamin D intake (from foods and supplements) was associated with a decreased risk of CVD in men but not in women; the relative risks (95% CIs) for a comparison of participants who met the Dietary Reference Intake of vitamin D (≥600 IU/d) with participants whose vitamin D intake was <100 IU/d were 0.84 (0.72, 0.97; P for trend = 0.009) for men and 1.02 (0.89, 1.17; P for trend = 0.12) for women" - See vitamin D at Amazon.com.
  • Link between phosphate intake and heart disease demonstrated in new study - Science Daily, 6/7/11 - "cholesterol deposits in the wall of arteries are increased following a higher phosphate diet. This leads to narrowing of the arteries, which is the cause of most heart attacks and strokes ... Food high in phosphate includes biscuits, cakes, sweets, dairy products and meats such as offal and veal" - Note:  They left out soda which is high in phosphate.
  • Effect of a traditional Mediterranean diet on apolipoproteins B, A-I, and their ratio: A randomized, controlled trial - Atherosclerosis. 2011 May 6 - "Apolipoprotein (Apo)B, ApoA-I, and their ratio could predict coronary heart disease (CHD) risk more accurately than conventional lipid measurements. Our aim was to assess the effect of a traditional Mediterranean diet (TMD) on apolipoproteins ... Participants assigned to a low-fat diet (control) (n=177), or TMDs (TMD+virgin olive oil (VOO), n=181 or TMD+nuts, n=193) received nutritional education and either free VOO (ad libitum) or nuts (dose: 30g/day). A 3-month evaluation was performed ... Both TMDs promoted beneficial changes on classical cardiovascular risk factors. ApoA-I increased, and ApoB and ApoB/ApoA-I ratio decreased after TMD+VOO, the changes promoting a lower cardiometabolic risk. Changes in TMD+VOO versus low-fat diet were -2.9mg/dL (95% CI, -5.6 to -0.08), 3.3mg/dL (95% CI, 0.84 to 5.8), and -0.03mg/dL (-0.05 to -0.01) for ApoB, ApoA-I, and ApoB/ApoA-I ratio, respectively ... Individuals at high-cardiovascular risk who improved their diet toward a TMD pattern rich in virgin olive oil, reduced their Apo B and ApoB/ApoA-I ratio and improved ApoA-I concentrations" - The question is; is it the polyphenols or the omega-9 or both in the virgin olive oil responsible for the benefit? See olive leaf extract at Amazon.com.
  • Heart failure risk lower in women who often eat baked/broiled fish - Science Daily, 5/24/11 - "In a large-scale analysis, women who ate the most baked/broiled fish (five or more servings/week) had a 30 percent lower risk of heart failure compared to women who seldom ate it (less than one serving/month) ... dark fish (salmon, mackerel and bluefish) were associated with a significantly greater risk reduction than either tuna or white fish (sole, snapper and cod) ... eating fried fish was associated with increased heart failure risk. Even one serving a week was associated with a 48 percent higher heart failure risk"
  • Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models - Atherosclerosis. 2011 May 5 - "In cultured human endothelial cells, quercetin protected against H(2)O(2)-induced lipid peroxidation and reduced the cytokine-induced cell-surface expression of VCAM-1 and E-selectin. Quercetin also reduced the transcriptional activity of NFκB in human hepatocytes. In human CRP transgenic mice (quercetin plasma concentration: 12.9+/-1.3μM), quercetin quenched IL1β-induced CRP expression, as did sodium salicylate. In ApoE*3Leiden mice, quercetin (plasma concentration: 19.3+/-8.3μM) significantly attenuated atherosclerosis by 40% (sodium salicylate by 86%). Quercetin did not affect atherogenic plasma lipids or lipoproteins but it significantly lowered the circulating inflammatory risk factors SAA and fibrinogen. Combined histological and microarray analysis of aortas revealed that quercetin affected vascular cell proliferation thereby reducing atherosclerotic lesion growth. Quercetin also reduced the gene expression of specific factors implicated in local vascular inflammation including IL-1R, Ccl8, IKK, and STAT3 ...Quercetin reduces the expression of human CRP and cardiovascular risk factors (SAA, fibrinogen) in mice in vivo. These systemic effects together with local anti-proliferative and anti-inflammatory effects in the aorta may contribute to the attenuation of atherosclerosis" - See quercetin at Amazon.com.
  • Cruciferous vegetable consumption is associated with a reduced risk of total and cardiovascular disease mortality - Am J Clin Nutr. 2011 May 18 - "Overall, fruit and vegetable intake was inversely associated with risk of total mortality in both women and men, and a dose-response pattern was particularly evident for cruciferous vegetable intake. The pooled multivariate hazard ratios (95% CIs) for total mortality across increasing quintiles of intake were 1 (reference), 0.91 (0.84, 0.98), 0.88 (0.77, 1.00), 0.85 (0.76, 0.96), and 0.78 (0.71, 0.85) for cruciferous vegetables (P < 0.0001 for trend) and 0.88 (0.79, 0.97), 0.88 (0.79, 0.98), 0.76 (0.62, 0.92), and 0.84 (0.69, 1.00) for total vegetables (P = 0.03 for trend). The inverse associations were primarily related to cardiovascular disease mortality but not to cancer mortality"
  • Damaged hearts pump better when fueled with fats, study suggests - Science Daily, 5/4/11 - "for a damaged heart, a balanced diet that includes mono- and polyunsaturated fats, and which replaces simple sugars (sucrose and fructose) with complex carbohydrates, may be beneficial ... researchers previously thought a high-fat diet fed to animal models that have suffered a heart attack, would overload their tissues with fat, which in turn would have a toxic effect on their hearts. Surprisingly, the heart's pump function improved on the high-fat diet. Through further testing, the researchers found that animal models suffering from heart failure and receiving a low fat diet were able to produce insulin and take up glucose from the blood, just as healthy hearts do. However, the biological models with heart failure that were fed high-fat diets showed signs of insulin resistance, exhibited by a decreased amount of glucose taken up by the heart, as might be expected in a diabetic patient ... One of the main implications of these findings is that contrary to previously held beliefs, a state of insulin-resistance might actually be beneficial to a failing heart"
  • Load up on fiber now, avoid heart disease later - Science Daily, 3/22/11 - "adults between 20 and 59 years old with the highest fiber intake had a significantly lower estimated lifetime risk for cardiovascular disease compared to those with the lowest fiber intake ... It's long been known that high-fiber diets can help people lose weight, lower cholesterol and improve hypertension ... In adults 60 to 79 years, dietary fiber intake was not significantly associated with a reduction in lifetime risk of cardiovascular disease. It's possible that the beneficial effect of dietary fiber may require a long period of time to achieve, and older adults may have already developed significant risk for heart disease before starting a high-fiber diet"
  • A Dietary Mixture Containing Fish Oil, Resveratrol, Lycopene, Catechins, and Vitamins E and C Reduces Atherosclerosis in Transgenic Mice - J Nutr. 2011 Mar 16 - "Chronic inflammation and proatherogenic lipids are important risk factors of cardiovascular disease (CVD). Specific dietary constituents such as polyphenols and fish oils may improve cardiovascular risk factors and may have a beneficial effect on disease outcomes ... AIDM was evaluated in an inflammation model, male human C-reactive protein (CRP) transgenic mice, and an atherosclerosis model, female ApoE*3Leiden transgenic mice. Two groups of male human-CRP transgenic mice were fed AIDM [0.567% (wt:wt) powder and 0.933% (wt:wt oil)] or placebo for 6 wk. The effects of AIDM on basal and IL-1β-stimulated CRP expression were investigated. AIDM reduced cytokine-induced human CRP and fibrinogen expression in human-CRP transgenic mice. In the atherosclerosis study, 2 groups of female ApoE*3Leiden transgenic mice were fed an atherogenic diet supplemented with AIDM [0.567% (wt:wt) powder and 0.933% (wt:wt oil)] or placebo for 16 wk. AIDM strongly reduced plasma cholesterol, TG, and serum amyloid A concentrations compared with placebo. Importantly, long-term treatment of ApoE*3Leiden mice with AIDM markedly reduced the development of atherosclerosis by 96% compared with placebo. The effect on atherosclerosis was paralleled by a reduced expression of the vascular inflammation markers and adhesion molecules inter-cellular adhesion molecule-1 and E-selectin. Dietary supplementation of AIDM improves lipid and inflammatory risk factors of CVD and strongly reduces atherosclerotic lesion development in female transgenic mice" - See resveratrol products at Amazon.com, Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com, Jarrow Formulas, CarotenALL at Amazon.com, green tea extract at Amazon.com and Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: A randomized controlled trial - Atherosclerosis. 2011 Feb 17 - "Coronary artery disease (CAD) is associated with endothelial dysfunction and mitochondrial dysfunction (MD) ... brachial flow-mediated dilation (FMD) in patients with ischaemic LVSD (left ventricular ejection fraction <45%) ... In patients with ischaemic LVSD, 8weeks supplement of CoQ improved mitochondrial function and FMD; and the improvement of FMD correlated with the change in mitochondrial function, suggesting that CoQ improved endothelial function via reversal of mitochondrial dysfunction in patients with ischaemic LVSD" - See ubiquinol products at Amazon.com.
  • Young rats given polyphenols show less endothelial function deterioration with aging - Science Daily, 1/31/11 - "The endothelium is the inner lining of our blood vessels and normal functions of endothelial cells include enabling coagulation, platelet adhesion and immune function. Endothelial dysfunction is associated with reduced anticoagulant properties and the inability of arteries and arterioles to dilate fully ... The gradual decrease in endothelial function over time is a key factor in the development of diseases associated with ageing, especially cardiovascular disease (CVD).  Many epidemiologic studies suggest protection against CVD from moderate intake of alcoholic beverages, especially those rich in antioxidants, such as red wine, which is high in polyphenols (RWPs) ... RWPs and apocynin improved the endothelial dysfunction, normalized oxidative stress and the expression of the different proteins. RWPs also improved ageing-related decline in physical exercise. Thus, intake of RWPs protects against ageing-induced endothelial dysfunction and decline in physical performance ... RWPs intake had also a physiological beneficial effect since it improved the physical exercise capacity of old rats" - See grape seed extract at Amazon.com and resveratrol products at Amazon.com.
  • α-Lipoic acid can improve endothelial dysfunction in subjects with impaired fasting glucose - Metabolism. 2011 Jan 19 - "Our data showed that IFG subjects have impaired endothelial function and that antioxidant α-lipoic acid can improve endothelial function through a decrease of oxygen-derived free radicals" - See alpha lipoic acid at Amazon.com.
  • HEPA filters reduce cardiovascular health risks associated with air pollution, study finds - Science Daily, 1/12/11 - "portable HEPA filters reduced the average concentrations of fine particulates inside homes by 60% and woodsmoke by 75%, and their use was associated with improved endothelial function (a 9.4% increase in reactive hyperemia index) and decreased inflammation (a 32.6% decrease in C-reactive protein)"
  • Tomatoes found to contain nutrient which prevents vascular diseases - Science Daily, 1/6/11 - "Tomatoes are already known to contain many compounds beneficial to health. In this study the team analyzed 9-oxo-octadecadienoic acid, to test its potential anti-dyslipidemia properties ... The compound was found to enhance fatty acid oxidation and contributed to the regulation of hepatic lipid metabolism. These findings suggest that 9-oxo-octadecadienoic acid has anti-dyslipidemia affects and can therefore help prevent vascular diseases" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men - Atherosclerosis. 2010 Dec 9 - "An increase in serum lycopene after supplementation can reduce oxidative stress which may play a role in endothelial function" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Three Whole-Grain Portions Daily May Lower Cardiovascular Risk - Medscape, 1/4/11 - "Daily consumption of 3 portions of whole-grain foods (WGF) is linked to lower cardiovascular disease (CVD) risk in healthy, middle-aged people mainly by lowering blood pressure (BP) ... assigned to continue the refined diet (control) or to switch to a whole-wheat diet or to a whole-wheat plus oat diet, for 12 weeks ... Compared with the control group, the WGF groups had a significant reduction in systolic BP (6 mm Hg) and a significant reduction (3 mm Hg) in pulse pressure ... The observed decrease in systolic blood pressure could decrease the incidence of coronary artery disease and stroke by ≥ 15% and 25%, respectively"
  • Fruit, vegetables, and olive oil and risk of coronary heart disease in Italian women: the EPICOR Study - Am J Clin Nutr. 2010 Dec 22 - "aimed to investigate the association between consumption of fruit, vegetables, and olive oil and the incidence of coronary heart disease (CHD) in 29,689 women enrolled between 1993 and 1998 ... A strong reduction in CHD risk among women in the highest quartile of consumption of leafy vegetables (hazard ratio: 0.54; 95% CI: 0.33, 0.90; P for trend = 0.03) and olive oil (hazard ratio: 0.56; 95% CI: 0.31, 0.99; P for trend = 0.04) was found. In contrast, no association emerged between fruit consumption and CHD risk"
  • Protective effect of lycopene on serum cholesterol and blood pressure: Meta-analyses of intervention trials - Maturitas. 2010 Dec 14 - "Lycopene, a carotenoid found in tomatoes ... Meta-analysis of the effect of lycopene on systolic blood pressure of all trials suggested a significant blood pressure reducing effect (mean systolic blood pressure change+/-SE: -5.60+/-5.26mm Hg, p=0.04) ... Our meta-analysis suggests that lycopene taken in doses ≥25mg daily is effective in reducing LDL cholesterol by about 10% which is comparable to the effect of low doses of statins in patient with slightly elevated cholesterol levels" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
  • Whey supplements lower blood pressure: Low-cost protein gets big results in people with elevated blood pressure - Science Daily, 12/8/10 - "Beverages supplemented by whey-based protein can significantly reduce elevated blood pressure, reducing the risk of stroke and heart disease ... daily doses of commonly available whey brought a more than six-point reduction in the average blood pressure of men and women with elevated systolic and diastolic blood pressures ... blood-pressure reductions like those seen by Fluegel can reduce cardiovascular disease and bring a 35 to 40 percent reduction in fatal strokes" - See whey protein at Amazon.com.
  • Chronic high cholesterol diet produces brain damage - Science Daily, 11/24/10 - "chronic high fat cholesterol diet in rats exhibited pathologies similar to Alzheimer's disease ... A third hypothesis suggests that chronic long-lasting mild cerebrovascular damage, including inflammatory processes and oxidative stress, may cause Alzheimer's disease ... chronic hypercholesterolemia [in rats] caused memory impairment, cholinergic dysfunction, inflammation, enhanced cortical beta-amyloid and tau and induced microbleedings, all indications, which resemble an Alzheimer's disease-like pathology"
  • Fish consumption and myocardial infarction: a second prospective biomarker study from northern Sweden - Am J Clin Nutr. 2010 Nov 3 - "fish also contains methylmercury, which may increase the risk of MI ... mercury (Ery-Hg) ... selenium (Ery-Se) ... (eicosapentaenoic and docosahexaenoic acids) in plasma phospholipids (P-EPA+DHA) ... sudden cardiac deaths (SCDs) ... Odds ratios for the third compared with the first tertile were 0.65 (95% CI: 0.46, 0.91) for Ery-Hg, 0.75 (95% CI: 0.53, 1.06) for Ery-Se, and 0.78 (95% CI: 0.54, 1.11) for P-EPA+DHA. Ery-Hg and P-EPA+DHA were intercorrelated (Spearman's R = 0.34). No association was seen for reported fish consumption ... High concentrations of Ery-Se were associated with an increased risk of SCD" - Note:  See my Toxins in Fish/Fish oil page.  Mercury has not been a problem in brand name supplements.  See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Chocolate eaters may have healthier hearts: study - MSNBC, 11/8/10 - "The authors found that women older than 70 who ate chocolate at least once per week were 35 percent less likely to be hospitalized or die from heart disease over the course of the study, and nearly 60 percent less likely to be hospitalized or die from heart failure ... The danger is that many people will start eating more of it than is necessary, without cutting back in calories from other snacks, which will result in weight gain and will counteract any beneficial effects of chocolate ... Flavonoids are thought to reduce the risk of heart disease, the leading cause of death in many industrialized countries, by helping to increase nitric oxide, which in turn helps boost the functioning of blood vessels and lower blood pressure"
  • Eating mostly whole grains, few refined grains linked to lower body fat - Science Daily, 10/20/10 - "People who consume several servings of whole grains per day while limiting daily intake of refined grains appear to have less of a type of fat tissue thought to play a key role in triggering cardiovascular disease and type 2 diabetes ... Visceral Adipose Tissue ... VAT volume was approximately 10 % lower in adults who reported eating three or more daily servings of whole grains and who limited their intake of refined grains to less than one serving per day ... Visceral fat surrounds the intra-abdominal organs while subcutaneous fat is found just beneath the skin ... visceral fat is more closely tied to the development of metabolic syndrome ... participants who consumed, on average, three daily servings of whole grains but continued to eat many refined grains did not demonstrate lower VAT volume"
  • Serum Magnesium and Risk of Sudden Cardiac Death in the Atherosclerosis Risk in Communities (ARIC) Study - Medscape, 10/19/10 - "sudden cardiac death (SCD) ... SCD was inversely associated with serum Mg (P for linear trend < .0001). Compared with the lowest quartile of Mg, the risk of SCD was 55% lower (HR 0.45, 95% CI 0.31–0.67) in the highest Mg quartile and 47% lower in the second highest quartile (HR 0.53, 95% CI 0.38–0.74)" - See Jarrow Formulas, Magnesium Optimizer Citrate at Amazon.com.
  • Association of Japanese dietary pattern with serum adiponectin concentration in Japanese adult men - Nutr Metab Cardiovasc Dis. 2010 Sep 27 - "Although previous studies suggest that the traditional Japanese dietary pattern is independently associated with a low cardiovascular disease mortality risk, the mechanisms mediating or linking this association are not well understood. Adiponectin has emerged as a valuable biomarker for cardiovascular diseases ... Greater adherence to the "Japanese" dietary pattern was independently associated to a higher serum adiponectin concentration in Japanese adult men. This finding supports the hypothesis that the traditional Japanese diet may have a potentially beneficial effect on adiponectin concentrations"
  • Sulphoraphane inhibited the expressions of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 through MyD88-dependent toll-like receptor-4 pathway in cultured endothelial cells - Nutr Metab Cardiovasc Dis. 2010 Sep 27 - "Chronic inflammation plays pivotal roles in both cancer and cardiovascular diseases. A large body of evidence suggests that high intake of cruciferous vegetables is closely related with low risk of these disorders ... Taken all together, adhesion molecules are confirmed to be the novel targets of sulphoraphane in preventing inflammatory insult to endothelial cells. Sulphoraphane suppressed TLR-4 followed by MyD88 and downstream factors such as p38 MAPK and JNK, ultimately blocking NF-кB translocation and the subsequent expression of adhesion molecules. These data suggested a novel inflammatory pathway mediated by sulphoraphane" - See sulforaphane at Amazon.com.
  • Garlic oil may reverse diabetes linked heart disease - Nutra USA, 9/30/10 - "garlic oil supplementation for diabetic rats leads to several alterations at multiple levels in hearts including cardiac contractile functions and structures, myosin chain gene expressions, oxidative stress, and apoptosis and related signaling activities" - [Abstract]
  • Cardiac Contractile Dysfunction and Apoptosis in Streptozotocin-Induced Diabetic Rats Are Ameliorated by Garlic Oil Supplementation - J Agric Food Chem. 2010 Sep 13 - "these diabetes-related cardiac dysfunctions were almost dose-dependently ameliorated by garlic oil administration. In conclusion, garlic oil possesses significant potential for protecting hearts from diabetes-induced cardiomyopathy" - See garlic oil products at iHerb.
  • Garlic oil shows protective effect against heart disease in diabetes - Science Daily, 9/29/10 - "Garlic has "significant" potential for preventing cardiomyopathy, a form of heart disease that is a leading cause of death in people with diabetes ... people with diabetes have at least twice the risk of death from heart disease as others ... The scientists fed either garlic oil or corn oil to laboratory rats with diabetes. Animals given garlic oil experienced beneficial changes associated with protection against heart damage" - See garlic supplements at Amazon.com.
  • Low serum magnesium concentrations predict increase in left ventricular mass over 5 years independently of common cardiovascular risk factors - Atherosclerosis. 2010 Sep 21 - "Mg(2+) at baseline (0.790+/-0.003mmol/l, mean+/-SEM) inversely correlated with the difference in LVM over 5 years (p<0.0001, females: p<0.002, males: p<0.024). In the lowest Mg(2+)-quintile (Mg(2+)<=0.73mmol/l), LVM (187.4+/-3.1g at baseline) increased by 14.9+/-1.2g, while in the highest Mg(2+)-quintile (Mg(2+)>=0.85mmol/l) LVM (186.7+/-3.4g at baseline) decreased by -0.5+/-2.8g (p<0.0001 between quintiles). By multivariable analysis including several cardiovascular risk factors and antihypertensive treatment, serum Mg(2+) was associated with the increase in LVM at a statistically high significant level (p<0.0001). LVM after 5 years was significantly higher in subjects within the lower Mg(2+)-quintiles. This association remained highly significant after adjustment for several cardiovascular risk factors including arterial hypertension and diabetes mellitus" - See magnesium supplements at Amazon.com.
  • Chocolate consumption is inversely associated with prevalent coronary heart disease: The National Heart, Lung, and Blood Institute Family Heart Study - Clin Nutr. 2010 Sep 19 - "Compared to subjects who did not report any chocolate intake, odds ratios (95% CI) for CHD were 1.01 (0.76-1.37), 0.74 (0.56-0.98), and 0.43 (0.28-0.67) for subjects consuming 1-3 times/month, 1-4 times/week, and 5+ times/week, respectively (p for trend <0.0001) adjusting for age, sex, family CHD risk group, energy intake, education, non-chocolate candy intake, linolenic acid intake, smoking, alcohol intake, exercise, and fruit and vegetables. Consumption of non-chocolate candy was associated with a 49% higher prevalence of CHD comparing 5+/week vs. 0/week [OR = 1.49 (0.96-2.32)]"
  • Frequent chocolate consumption could reduce CHD risk, US study - Nutra USA, 9/21/10 - "dark chocolate intake was associated with a 39 per cent lower risk of myocardial infarction and stroke combined ... In the fully adjusted model, consumption of chocolate more than five times a week was associated with 57 per cent lower prevalent CHD compared with subjects who did not consume chocolate ... Exclusion of subjects with prevalent diabetes and those who were on a weight loss diet made the association stronger ... the inability to distinguish the different types of chocolate might have led to an underestimation of the true association between cocoa/chocolate polyphenol consumption and CHD in the study"
  • Dietary polyphenols: Focus on resveratrol, a promising agent in the prevention of cardiovascular diseases and control of glucose homeostasis - Nutr Metab Cardiovasc Dis. 2010 Oct;20(8):618-25 - "Plants continuously produce an extraordinary variety of biologically active low-molecular-mass compounds. Among them, resveratrol (3,5,4'-trihydroxystilbene) is endowed with significant positive activities by protecting against cardiovascular diseases and preventing the development and progression of atherosclerosis. Furthermore, the molecule significantly ameliorates glucose homeostasis in obese mice. These beneficial effects have driven considerable interest towards resveratrol molecular activities, and intensive efforts for the identification of the stilbene targets have been made. The molecule shows a pleiotropic mode of action. Particularly, its cellular targets are crucial for cell proliferation and differentiation, apoptosis, antioxidant defence and mitochondrial energy production. The complexity of resveratrol activities might account for its effectiveness in ameliorating multifactorial processes, including the onset and/or progression of several degenerative diseases such as myocardial infarction, atherosclerosis and type 2 diabetes" - See resveratrol products at Amazon.com.
  • Resveratrol improves myocardial perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemia - Circulation. 2010 Sep 14;122(11 Suppl):S142-9 - "hypercholesterolemic diet with supplemental resveratrol (100 mg/kg/d orally, HCRV ... Total cholesterol was lowered about 30% in HCRV animals (P<0.001). Regional wall motion analysis demonstrated a significant decrease in inferolateral function from baseline to 7 weeks in HCC swine (P=0.04). There was no significant change in regional function in HCRV swine from baseline to 7 weeks (P=0.32). Tissue blood flow during stress was 2.8-fold greater in HCRV swine when compared with HCC swine (P=0.04). Endothelium-dependent microvascular relaxation response to Substance P was diminished in HCC swine, which was rescued by resveratrol treatment (P=0.004). Capillary density (PECAM-1 staining) demonstrated fewer capillaries in both HCC and HCRV swine versus control swine (P=0.02). Immunoblot analysis demonstrated significantly greater expression in HCRV versus HCC swine of the following markers of angiogenesis: VEGF (P=0.002), peNOS (ser1177) (P=0.04), NFkB (P=0.004), and pAkt (thr308) (P=0.001) ... Supplemental resveratrol attenuates regional wall motion abnormalities, improves myocardial perfusion in the collateral dependent region, preserves endothelium-dependent coronary vessel function, and upregulates markers of angiogenesis associated with the VEGF signaling pathway" - See resveratrol products at Amazon.com.
  • Cardiac hypertrophy and remodelling: pathophysiological consequences and protective effects of melatonin - J Hypertens. 2010 Sep;28 Suppl 1:S7-12 - "Whereas melatonin did not reduce left ventricular hypertrophy in spontaneously hypertensive rats or in nitric oxide-deficient hypertension, it did have other beneficial effects, e.g. it curtailed oxidative damage to the heart that resulted in an attenuation of left ventricular fibrosis. In contrast to the findings in hypertensive rats, melatonin administration was effective in overcoming cardiac enlargement resulting from induced hyperthyroidism or chronic hypoxia exposure. In addition, in these situations, melatonin also conferred protection against free radical-mediated damage at the level of cardiomyocytes. Collectively, the results of the publications summarized herein along with numerous other published reports on other aspects of cardiovascular physiology indicate that, when damage to the heart is a result of free radicals, melatonin is clearly protective. This is not unexpected considering the now well documented potent antioxidative actions of both melatonin and its metabolites. In general, melatonin improves cardiovascular physiology and heart function" - See my favorite Source Naturals, Melatonin, Peppermint Flavored Sublingual, 1 mg, 300 Tablets at iHerb.
  • Melatonin improves the restoration of endothelium-derived constricting factor signalling and inner diameter in the rat femoral artery after cessation of L-NAME treatment - J Hypertens. 2010 Sep;28 Suppl 1:S19-2 - "Although melatonin did not accelerate blood pressure reduction, it attenuated EDCF-contractions and oxidative load and enlarged arterial diameter. These effects may be beneficial for cardiovascular protection" - See melatonin at Amazon.com.
  • Continuous light and L-NAME-induced left ventricular remodelling: different protection with melatonin and captopril - J Hypertens. 2010 Sep;28 Suppl 1:S13-8 - "In hypertension induced by a combination of continuous light and L-NAME treatment, melatonin and captopril protect the heart against pathological left ventricular remodelling differently" - See melatonin at Amazon.com.
  • Serum magnesium and risk of sudden cardiac death in the Atherosclerosis Risk in Communities (ARIC) Study - Am Heart J. 2010 Sep;160(3):464-70 - "sudden cardiac death (SCD) ... Individuals in the highest quartile of serum Mg were at significantly lower risk of SCD in all models. This association persisted after adjustment for potential confounding variables, with an almost 40% reduced risk of SCD (hazard ratio 0.62, 95% CI 0.42-0.93) in quartile 4 versus 1 of serum Mg observed in the fully adjusted model ... This study suggests that low levels of serum Mg may be an important predictor of SCD" - See magnesium supplements at Amazon.com.
  • 'Jailbreak' bacteria can trigger heart disease - Science Daily, 9/5/10 - "Poor dental hygiene can lead to bleeding gums, providing bacteria with an escape route into the bloodstream, where they can initiate blood clots leading to heart disease"
  • Vitamin D is a prognostic marker in heart failure, study finds - Science Daily, 8/31/10 - "Survival rates in heart failure patients with reduced levels of vitamin D are lower than in patients with normal levels ... Results also suggest that low levels of vitamin D are associated with activation of the Renin Angiotensin System (RAS -- a pivotal regulatory system in heart failure) and an altered cytokine profile" - See vitamin D at Amazon.com.
  • Iron deficiency in heart failure - Science Daily, 8/31/10 - "Iron deficiency is a relatively common nutritional disorder that affects more than one third of the general population, and is often associated with chronic diseases such as inflammatory bowel disease, Parkinson's disease, rheumatoid diseases and renal failure ... iron deficiency must be viewed in a much broader clinical context, as it also affects at least one-third of non-anaemic CHF patients ... Iron deficiency appears to be independent of the severity of CHF symptoms, and occurs irrespective of anaemia. It also seems to be associated with exercise intolerance and leads to a reduced quality of life. Our research shows that it probably constitutes an ominous sign of a poor outcome, independently of the other well-established prognosticators. In light of its high prevalence and clinical consequences, iron deficiency may well be perceived as an attractive therapeutic target in CHF" - See Slow Fe Slow Release Iron Tablets 90-Count Box at Amazon.com.
  • DHEA-S Levels and Cardiovascular Disease Mortality in Postmenopausal Women - J Clin Endocrinol Metab. 2010 Aug 25 - "Women in the lowest DHEA-S tertile had higher CVD mortality (17% 6-yr mortality rate vs. 8%; log-rank P = 0.011), and all-cause mortality (21 vs. 10%; P = 0.011) compared with women with higher DHEA-S levels. The increased CVD mortality risk [hazard ratio (HR) = 2.55; 95% confidence interval (CI) = 1.19-5.45] remained unchanged after adjustment for multiple CVD risk factors (HR = 2.43; 95% CI = 1.06-5.56) but became nonsignificant when further adjusting for the presence or severity of angiographic obstructive CAD (HR = 1.99; 95% CI = 0.87-4.59). Results were similar for all-cause mortality. Lower DHEA-S levels were only marginally but not independently associated with obstructive CAD" - See DHEA at Amazon.com.
  • Major Dietary Protein Sources and Risk of Coronary Heart Disease in Women - Circulation. 2010 Aug 16 - "26 years of follow-up ... higher intakes of red meat, red meat excluding processed meat, and high-fat dairy were significantly associated with elevated risk of CHD. Higher intakes of poultry, fish, and nuts were significantly associated with lower risk. In a model controlling statistically for energy intake, 1 serving per day of nuts was associated with a 30% (95% confidence interval, 17% to 42%) lower risk of CHD compared with 1 serving per day of red meat. Similarly, compared with 1 serving per day of red meat, a lower risk was associated with 1 serving per day of low-fat dairy (13%; 95% confidence interval, 6% to 19%), poultry (19%; 95% confidence interval, 3% to 33%), and fish (24%; 95% confidence interval, 6% to 39%). Conclusions-These data suggest that high red meat intake increases risk of CHD and that CHD risk may be reduced importantly by shifting sources of protein in the US diet"
  • N-3 polyunsaturated fatty acids early supplementation improves ultrasound indices of endothelial function, but not through NO inhibitors in patients with acute myocardial infarction N-3 PUFA supplementation in acute myocardial infarction - Clin Nutr. 2010 Aug 11 - "the study group (group P; n = 20; standard therapy + n-3 PUFA 1g daily) or the control group (group C; n = 20; standard therapy) ... There was a significant difference between both groups in mean delta (baseline/after one month) FMD (P: 8.1 +/- 12.6% vs C: -2.2 +/- 11.8%; p = 0.02) with no difference in mean delta NMD (P: 3.3 +/- 11.9% vs 0.66 +/- 14.3%; p = 0.53). We found also a significant increase in mean FMD (7.4 +/- 6.4 to 15.5 +/- 10.5%; p = 0.02) with a nonsignificant change in mean NMD values (26.9 +/- 12.1 to 30.2 +/- 14.0%; p = 0.24) after 1-month therapy with n-3 PUFA. FMD and NMD mean values did not change in control patients (FMD: 11.6 +/- 6.1% to 9.4 +/- 8.0%; p = 0.5 NMD: 25.1 +/- 11.4% to 25.8 +/- 14.0%; p = 0.84). The comparison of mean delta ADMA values for both groups revealed no differences (P: 6.2 +/- 9.7 mumol/l vs C: 3.6 +/- 9.5 mumol/l; p = 0.43). Mean serum ADMA concentrations were significantly increased after 1-month therapy in the group P (P: 2.1 +/- 1.8 to 8.3 +/- 9.7 mumol/l; p = 0.001; C: 4.5 +/- 7.1 to 8.1 +/- 9.5 mumol/l; p = 0.09). However, there was a nonsignificant difference in mean baseline serum ADMA levels between both groups (P: 2.1 +/- 1.8 mumol/l vs C: 4.5 +/- 7.1 mumol/l; p = 0.32). There were no significant correlations between FMD, NMD, ADMA levels and demographic, clinical or biochemical parameters. CONCLUSIONS: Early and short-term n-3 PUFA supplementation improved ultrasound indices of endothelial function without affecting serum ADMA levels in patients with AMI and successful primary PCI" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Bilberry anthocyanin-rich extract alters expression of genes related to atherosclerosis development in aorta of apo E-deficient mice - Nutr Metab Cardiovasc Dis. 2010 Jul 31 - "bilberry anthocyanin-rich extract (BE) ... BE supplementation significantly improved hypercholesterolemia whereas the plasmatic antioxidant status remained unchanged. Nutrigenomic analysis identified 1261 genes which expression was modulated by BE in the aorta. Bioinformatic analysis revealed that these genes are implicated in different cellular processes such as oxidative stress, inflammation, transendothelial migration and angiogenesis, processes associated with atherosclerosis development/protection. Some of the most significantly down-regulated genes included genes coding for AOX1, CYP2E1 or TXNIP implicated in the regulation of oxidative stress, JAM-A coding for adhesion molecules or VEGFR2 implicate in regulation of angiogenesis. Other genes were up-regulated, such as CRB3, CLDN14 or CDH4 potentially associated with increased cell-cell adhesion and decreased paracellular permeability. These results provide a global integrated view of the mechanisms involved in the preventive action of bilberry anthocyanin-rich extract against atherosclerosis" - See bilberry at Amazon.com.
  • Red meat consumption and risk of heart failure in male physicians - Nutr Metab Cardiovasc Dis. 2010 Jul 30 - "there was a positive and graded relation between red meat consumption and HF [hazard ratio (95% CI) of 1.0 (reference), 1.02 (0.85-1.22), 1.08 (0.90-1.30), 1.17 (0.97-1.41), and 1.24 (1.03-1.48) from the lowest to the highest quintile of red meat, respectively"
  • Industry : Calcium research “cherry picked” results - Nutra USA, 7/30/10
  • Calcium supplements linked to increased risk of heart attack, study finds - Science Daily, 7/29/10 - "calcium supplements were associated with about a 30% increased risk of heart attack and smaller, non-significant, increases in the risk of stroke and mortality"
  • Calcium supplements play an important role in maintaining bone health, experts say - Science Daily, 7/29/10 - "The authors of the meta-analysis examined the effects of calcium supplements on the risk of cardiovascular events, concluding there is an increased risk, and calling for a reassessment of the role of calcium supplements for osteoporosis. According to CRN, these conclusions are dramatically overstated, considering the limitations of meta-analysis, in general, and this meta-analysis, specifically ... The authors characterize these findings as though all of the selected studies suggest increased risk. In fact, the opposite is true: most of the studies do not suggest increased risk ... these researchers are making sweeping judgments about the value of calcium supplements by only assessing a handful of handpicked studies ..."
  • Vitamin D levels and mortality in type 2 diabetes - Diabetes Care. 2010 Jul 6 - "All-cause mortality was increased in patients with severe vitamin D deficiency; HR [95% CI] 1.96 [1.29-2.98] ... Severe vitamin D deficiency was associated with increased cardiovascular mortality; HR 1.95 [1.11-3.44]" - See vitamin D at Amazon.com.
  • Dietary Fiber Intake Is Associated with Reduced Risk of Mortality from Cardiovascular Disease among Japanese Men and Women - J Nutr. 2010 Jun 23 - "Total, insoluble, and soluble dietary fiber intakes were inversely associated with risk of mortality from CHD and total CVD for both men and women. For men, the multivariable HR (95% CI) for CHD in the highest vs. the lowest quintiles were 0.81 [(95% CI, 0.61-1.09); P-trend = 0.02], 0.48 [(95% CI, 0.27-0.84); P-trend < 0.001], and 0.71 [(95% CI, 0.41-0.97); P-trend = 0.04] for total, insoluble, and soluble fiber, respectively. The respective HR (95% CI) for women were 0.80 [(95% CI, 0.57-0.97); P-trend = 0.01], 0.49 [(95% CI, 0.27-0.86); P-trend = 0.004], and 0.72 [(95% CI, 0.34-0.99); P-trend = 0.03], respectively. For fiber sources, intakes of fruit and cereal fibers but not vegetable fiber were inversely associated with risk of mortality from CHD. In conclusion, dietary intakes of fiber, both insoluble and soluble fibers, and especially fruit and cereal fibers, may reduce risk of mortality from CHD"
  • Effect of Long-Term L-Arginine Supplementation on Arterial Compliance and Metabolic Parameters in Patients with Multiple Cardiovascular risk Factors: Randomized, Placebo-Controlled Study - J Cardiovasc Pharmacol. 2010 Jun 7 - "large artery elasticity index (LAEI) ... Although large artery elasticity index (LAEI) did not differ significantly between the groups at baseline (10.64.3 vs.11.64.5 ml/mm HgX100, p=0.346), at the end of the study LAEI was significantly greater in patients treated with L-arginine than in the placebo group (12.73.4 vs. 8.02.8 ml/mm HgX10, p<0.0001). Systemic vascular resistance was significantly lower in patients treated with L-arginine than in the placebo group after 6 months. Small artery elasticity index (SAEI) did not differ significantly between the groups at baseline or at the end of the study. Serum aldosterone decreased significantly in Group 1 from 10.76.3 to 8.45.0 ng/ml (p=0.008), but did not change in the placebo group. CONCLUSION:: L-arginine supplementation improves LAEI in patients with multiple cardiovascular risk factors. This improvement was associated with a decrease in systolic blood pressure, peripheral vascular resistance as well as a decrease in aldosterone levels. The results suggest that long term L-arginine supplementation has beneficial vascular effects in pathologic disease states associated with endothelial dysfunction" - See L-arginine products at Amazon.com.
  • Mediterranean-style diet improves heart function, twin study shows - Science Daily, 6/15/10 - "heart rate variability (HRV) ... Eating a Mediterranean-style diet -- one characterized by low saturated fats and high in fish, fruits, vegetables, legumes, nuts, olive oil, cereals and moderate alcohol consumption -- reduces a person's heart disease risk ... the higher a person's diet score, the more variable the heart beat-to-beat time interval -- 10 percent to 58 percent (depending on the HRV measure considered) for men in the top Mediterranean diet score quarter compared to those in the lowest quarter; this equates to a 9 percent to 14 percent reduction in heart-related death"
  • Plasma Matrix Metalloproteinase (MMP)-9 Levels Are Reduced following Low-Calorie Cranberry Juice Supplementation in Men - J Am Coll Nutr. 2009 Dec;28(6):694-701 - "Matrix metalloproteinase (MMP)-9, also known as gelatinase B, is implicated in the development of hypertension and atherosclerotic plaque vulnerability to rupture, an important step in the etiology of cardiovascular diseases ... cranberry juice cocktail (CJC) ... We found that CJC supplementation significantly decreased plasma MMP-9 concentrations (mean +/- SEM: -36% +/- 9%, p < 0.0005; week 12 vs. baseline) while baseline plasma MMP-9 concentrations strongly correlated with the changes noted over the entire intervention (r = -0.71, p < 0.0001). We also show that the reduction in plasma MMP-9 levels was associated with a change in plasma nitrites/nitrates (NOx) concentration over the entire intervention (r = -0.38, p < 0.05; week 12 vs. baseline). Significant correlations were also noted between changes in plasma MMP-9 levels and those of systolic (r = 0.39, p < 0.05) and diastolic (r = 0.60, p < 0.001) blood pressure during the course of the study (week 12 vs. baseline). CONCLUSIONS: Our results show that daily CJC consumption is associated with a decrease in plasma MMP-9 concentrations in abdominally obese men. We hypothesize that polyphenolic compounds from cranberries may be responsible for this effect, supporting the notion that the consumption of flavonoid-rich foods can exert cardioprotective effects" - See cranberry extract at Amazon.com.
  • Brushing Teeth May Keep Away Heart Disease - WebMD, 5/27/10 - "people who admitted to brushing their teeth less frequently had a 70% extra risk of heart disease ... People who reported poor oral hygiene also tested positive for bloodstream inflammatory markers such as fibrinogen and C-reactive protein"
  • Anti-atherogenic effects of resveratrol - Eur J Clin Nutr. 2010 May 19 - "RS exerts several health benefits including anti-atherogenic, anti-inflammatory and anti-cancer effects. RS may also prevent lipid oxidation, platelet aggregation, arterial vasodilation and modulates the levels of lipids and lipoproteins. As a potent, anti-oxidant RS reduces oxidative stress and regenerates alpha-tocopherol, which further strengthens the anti-oxidant defense mechanism. RS has been considered safe as no significant toxic effects have been identified, even when consumed at higher concentrations. This evidence identified RS as an effective anti-atherogenic agent, which could be used in the prevention and treatment of CVD" - See resveratrol products at Amazon.com.
  • Bran Reduces Heart Disease Deaths - WebMD, 5/10/10 - "women who ate the most bran had a 35% lower risk of death from heart disease and a 28% lower risk of death from all causes than women who ate the least"
  • Couple of Coffees May Help Some Heart Patients - Medscape, 5/7/10 - "A study of 374 patients who had a heart attack or other acute coronary event found those with normal blood pressure drinking one or two coffees a day were 88% less likely than non-coffee drinkers to develop left ventricular systolic dysfunction (LVSD)"
  • Grapes reduce risk factors for heart disease and diabetes, animal study shows - Science Daily, 5/10/10 - "After three months, the rats that received the grape-enriched diet had lower blood pressure, better heart function, and reduced indicators of inflammation in the heart and the blood than rats who received no grape powder. Rats also had lower triglycerides and improved glucose tolerance" - See Jarrow Formulas, OPCs + 95, 100 mg, 100 Capsules.
  • Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression - Lipids Health Dis. 2010 Apr 19;9(1):40 - "Curcumin inhibits cholesterol uptake through suppression of NPC1L1 expression in the intestinal cells"
  • Diet high in B vitamins lowers heart risks in Japanese study - Science Daily, 4/15/10 - "The findings on the value of B vitamins were consistent with studies in Europe and North America, although the dietary consumption of vitamin B-6 is generally lower in Japan than in the United States ... Comparing those with the diets lowest and highest for each nutrient, they found that higher consumption of folate and vitamin B-6 was associated with significantly fewer deaths from heart failure in men, and significantly fewer deaths from stroke, heart disease and total cardiovascular diseases in women"
  • Coffee Consumption and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Japanese Women - J Nutr. 2010 Mar 24 - "In women, the multivariate hazard ratios (HR) (95% CI) for all-cause mortality in participants who drank coffee never, occasionally, 1-2 cups (150-300 mL)/d, and >/=3 cups/d were 1.00, 0.88 (0.73-1.06), 0.82 (0.66-1.02), and 0.75 (0.53-1.05), respectively (P-trend = 0.04). For CVD mortality in women, the multivariate HR (95% CI) were 1.00, 0.56 (0.36-0.86), 0.48 (0.29-0.80), and 0.45 (0.20-1.03), respectively (P-trend = 0.006). Of the specific CVD diseases, there was a strong inverse association between coffee consumption and mortality due to coronary heart disease (CHD) in women (P-trend = 0.02) but not in men. Death due to cancer was not associated with coffee consumption in either men or women, except for colorectal cancer in women. Our results suggest that coffee may have favorable effects on morality due to all causes and to CVD, especially CHD, in women"
  • Marine (n-3) Fatty Acids, Fish Consumption, and the 10-Year Risk of Fatal and Nonfatal Coronary Heart Disease in a Large Population of Dutch Adults with a Low Fish Intake - J Nutr. 2010 Mar 24 - "Compared with the lowest quartile of EPA+DHA, participants in the top quartile had a 49% lower risk of fatal CHD (95% CI: 6-73%) and a 62% lower risk of fatal MI (95% CI: 23-81%). We observed inverse dose-response relations for EPA+DHA intake and fatal CHD (P-trend = 0.05) and fatal MI (P-trend = 0.01)" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Treating vitamin D deficiency significantly reduces heart disease risk, studies find - Science Daily, 3/15/10 - "Preventing and treating heart disease in some patients could be as simple as supplementing their diet with extra vitamin D ... For the first study ... 47 percent of the patients who increased their levels of vitamin D between the two visits showed a reduced risk for cardiovascular disease ... In the second study ... The patients in each category who increased their vitamin D levels to 43 nanograms per milliliter of blood or higher had lower rates of death, diabetes, cardiovascular disease, myocardial infarction, heart failure, high blood pressure, depression, and kidney failure. Currently, a level of 30 nanograms per milliliter is considered "normal" ... Increasing vitamin D intake by 1000 to 5000 international units (IU) a day may be appropriate" - See vitamin D at Amazon.com.
  • Effect of Niacin Therapy on Cardiovascular Outcomes in Patients With Coronary Artery Disease - J Cardiovasc Pharmacol Ther. 2010 Mar 5 - "Compared to placebo group, niacin therapy significantly reduced coronary artery revascularization (RR [relative risk]: 0.307 with 95% CI: 0.150-0.628; P = .001), nonfatal myocardial infarction ([MI]; RR: 0.719; 95% CI: 0.603-0.856; P = .000), stroke, and TIA ([transient ischemic attack] RR: 0.759; 95%CI: 0.613-0.940; P = .012), as well as a possible but nonsignificant decrease in cardiac mortality (RR: 0.883: 95% CI: 0.773-1.008; p= 0.066). CONCLUSIONS: In a meta-analysis of seven trials of secondary prevention, niacin was associated with a significant reduction in cardiovascular events and possible small but non-significant decreases in coronary and cardiovascular mortality" - See niacin at Amazon.com.
  • Risks from low potassium in heart failure patients with chronic kidney disease - Science Daily, 2/22/10 - "In findings reported in January in Circulation: Heart Failure, a journal of the American Heart Association, the researchers say that even a mild decrease in serum potassium level increased the risk of death in this patient group ... Hypokalemia, or low potassium, is common in heart-failure patients and is associated with poor outcomes, as is chronic kidney disease ... Death occurred in 48 percent of the patients with hypokalemia during the 57-month follow-up period, compared with only 36 percent of patients with normal potassium. The vast majority of subjects, 87 percent, had mild hypokalemia" - See potassium citrate at Amazon.com.
  • High levels of vitamin D in older people can reduce heart disease and diabetes - Science Daily, 2/16/10 - "Researchers looked at 28 studies including 99,745 participants across a variety of ethnic groups including men and women. The studies revealed a significant association between high levels of vitamin D and a decreased risk of developing cardiovascular disease (33% compared to low levels of vitamin D), type 2 diabetes (55% reduction) and metabolic syndrome (51% reduction)" - See vitamin D at Amazon.com.
  • Red clover extract: a source for substances that activate peroxisome proliferator-activated receptor alpha and ameliorate the cytokine secretion profile of lipopolysaccharide-stimulated macrophages - Menopause. 2010 Feb 5 - "In lipopolysaccharide-stimulated macrophages, red clover extract and its compounds reduced the secretion of proinflammatory cytokines, interleukin-6 and tumor necrosis factor alpha, increased the secretion of the anti-inflammatory interleukin-10, and/or reduced the expression of nuclear factor-kappaB, inducible nitric oxide synthase, and/or cyclooxygenase 2. Tumor necrosis factor alpha production was most efficiently reduced by biochanin A and genistein. Interleukin-6 levels were most efficiently reduced by genistein and equol. CONCLUSIONS:: Owing to its PPARalpha activation and modulation of the secreted cytokine profile, red clover extract is a putative candidate for preventing atherosclerosis and, thus, cardiovascular disease" - See Trinovin at Amazon.com.
  • OPCs come out tops for heart health beverages - Nutra USA, 2/5/10 - "Cranberry juice rich in antioxidant procyanidins is effective at boosting the health of blood vessels ... oligomeric procyanidins (OPC) had “by far the most potent effects” on the function of the endothelium (the cells lining blood vessels)" - [Abstract] - See cranberry extract at Amazon.comand grape seed extract at Amazon.com.
  • Regulation of Vascular Endothelial Function by Procyanidin-Rich Foods and Beverages (dagger) - J Agric Food Chem. 2010 Jan 28 - "Evaluation of the relative effects of extracts of cranberry juice compared to apple, cocoa, red wine, and green tea showed inhibition of ET-1 synthesis was dependent primarily on their oligomeric procyanidin content. Procyanidin-rich extracts of cranberry juice triggered morphological changes in endothelial cells with reorganization of the actin cytoskeleton and increased immunostaining for phosphotyrosine residues ... procyanidin tetramer, pentamer, hexamer, and heptamer produced concentration-dependent decreases with IC(50) values of 5.4, 1.6, 0.9, and 0.7 muM, respectively. Levels of ET-1 mRNA showed a similar pattern of decreases, which were inversely correlated with increased expression of Kruppel-like factor 2 (KLF2), a key endothelial transcription factor with a broad range of antiatherosclerotic actions including suppression of ET-1 synthesis" - See cranberry extract at Amazon.comand grape seed extract at Amazon.com.
  • High Omega-3 Levels May Slow Aging in Heart Patients - WebMD, 1/19/10 - "Heart disease patients with the highest blood levels of omega-3 fatty acids appear to age more slowly than those with the lowest blood levels ... Farzaneh-Far and his colleagues looked at a marker of biological age -- the rate of shortening of telomeres, structures at the end of a chromosome involved in its replication and stability. As the telomeres shorten over time, the eventual result is cell death, scientists believe ... In the new study, the higher the blood levels of omega-3 fatty acids in the patients evaluated, the slower the rate of telomere shortening ... patients with the lowest blood levels of omega-3 fatty acids exhibited a rate of telomere shortening 2.6 times faster than patients with the highest levels of omega-3 fatty acids" - [Science Daily] - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Low Vitamin D Has a Role in Heart Risk - WebMD, 1/7/10 - "Darker-skinned people produce less vitamin D from the sun than those with lighter skin, and studies show that blacks are far more likely to have lower levels of the vitamin than whites ... Several recent studies also suggest that low levels of vitamin D are associated with an increased risk for heart attack and stroke ... Compared to everyone else in the study, the quarter with the lowest vitamin D levels had a 40% higher risk of dying from heart attacks, strokes, and other heart-related events ... Blacks were 38% more likely to die of cardiovascular causes than non-Hispanic whites, and the researchers concluded that most of this excess was related to their lower vitamin D levels" - See vitamin D at Amazon.com.
  • Moderate Fish Consumption May Lower Risk in Patients with a History of Heart Failure - Science Daily, 12/18/09 - "Including fish in a balanced diet has long been associated with the prevention of heart disease, and scientists now believe that it can help preserve heart function in patients who have experienced heart failure. A new study in the Journal of Food Science reports that moderate fish consumption can help reduce the risk of left ventricular systolic dysfunction (LVSD) in post acute coronary syndrome (ACS) patients" - See Jarrow Max DHA at Amazon.com.
  • Sea of science deepens for fish heart benefits - Nutra USA, 12/16/09 - "left ventricular systolic dysfunction (LVSD) ... moderate fish consumption, defined as , was associated with 53 per cent reduction in the risk of developing LVSD compared to no/rare consumption of fish ... In addition, moderate fish consumption was associated with a lower inhibition of the nitric oxide synthase, an enzyme which produces nitric oxide – a potent vasodilator that relaxes blood vessels and improves blood flow" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com and glucosamine products at Amazon.com.
  • Vitamin D May Reduce Cardiac Work - Medscape, 12/10/09 - "Low serum levels of 25-hydroxyvitamin D are linked with increased heart rate and systolic blood pressure and with the rate-pressure product (RPP) ... The inverse association between vitamin D status and the rate-pressure product suggests that people with high vitamin D levels have hearts that work more efficiently" - See vitamin D at Amazon.com.
  • Continuous Aspirin May Lower Mortality Despite Increased Risk for Recurrent Peptic Ulcer Bleeding - Medscape, 12/1/09 - "Continuous low-dose aspirin therapy may increase the risk for recurrent peptic ulcer bleeding but potentially lowers mortality rates ... Compared with patients who received placebo, patients who received aspirin had lower all-cause mortality rates (1.3% vs 12.9%; difference, 11.6 percentage points; 95% CI, 3.7 - 19.5 percentage points). In addition, patients in the aspirin group had lower mortality rates resulting from cardiovascular, cerebrovascular, or gastrointestinal tract complications vs patients in the placebo group (1.3% vs 10.3%; difference, 9 percentage points; 95% CI, 1.7 - 16.3 percentage points)"
  • Alcohol May Reduce Men's Heart Risk - WebMD, 11/18/09 - "Drinking any type of alcohol lowered the risk of serious heart disease in men, with the amount of risk reduction associated with the amount of alcohol: ... Light drinking reduced risk by 35% ... Moderate drinking reduced risk by 51% ... High and very high levels of drinking reduced risk by 54% and 50% ... Light drinking was up to 5 grams a day -- or about one glass of wine, one and one-half beers, or less than a half glass of hard liquor ... Moderate drinking was 5 to 30 grams a day, or about two glasses of wine, two or three beers, or a half to one glass of hard liquor ... High and very high levels of drinking were 30 to 90 grams a day, or about five or more glasses of wine, seven or more beers, and one to one and a half glasses or more of hard liquor"
  • Inadequate levels of vitamin D may significantly increase risk of stroke, heart disease and death - Science Daily, 11/16/09 - "a new study by researchers at the Heart Institute at Intermountain Medical Center in Salt Lake City suggests that Vitamin D contributes to a strong and healthy heart as well -- and that inadequate levels of the vitamin may significantly increase a person's risk of stroke, heart disease, and death, even among people who've never had heart disease ... patients with very low levels of Vitamin D were 77 percent more likely to die, 45 percent more likely to develop coronary artery disease, and 78 percent were more likely to have a stroke than patients with normal levels. Patients with very low levels of Vitamin D were also twice as likely to develop heart failure than those with normal Vitamin D levels ... Recently, studies have also linked Vitamin D to the regulation of many other bodily functions including blood pressure, glucose control, and inflammation, all of which are important risk factors related to heart disease" - See vitamin D at Amazon.com.
  • Niacin Tops Zetia in Cutting Artery Plaque - WebMD, 11/16/09 - "The question is whether ezetimibe works at all ... Niacin has been around for 50 years. It's a well-understood drug, and in this trial it was clearly superior ... Ultrasound images of neck arteries showed that Niaspan reduced artery plaque by about 2%. Zetia did not slow plaque buildup, although it did lower cholesterol" - See niacin at Amazon.com.
  • Low HDL Levels as the Most Common Metabolic Syndrome Risk Factor in Heart Failure - Int Heart J. 2009 Sep;50(5):571-80 - "The most prevalent parameters were low HDL-C (69%) and hypertension (69%) in all participants" -  Note:  The best way to raise HDL is with niacin.  The no flush form doesn't work and the slow release may cause liver damage.  People complain about the flush but I've been taking it for years and the longer you take it the less flush.  After a while, there is no flush at all but be sure to take it with food.  http://www.lipidsonline.org/slides/slide01.cfm?tk=25&dpg=34 shows that with extended release niacin, HDL peaks out at 2,500 mg.  http://www.lipidsonline.org/slides/slide01.cfm?q=effect+of+niacin&dpg=4 shows immediate release crystalline niacin compared to Niaspan.  The numbers are basically the same.  I don't see any point in the prescription other than that it might have less flushing when you first start taking it.  See niacin at Amazon.com.
  • Insufficient Levels Of Vitamin D Puts Elderly At Increased Risk Of Dying From Heart Disease - Science Daily, 9/21/09 - "Compared to those with optimal vitamin D status, those with low vitamin D levels were 3 times more likely to die from heart disease and 2.5 times more likely to die from any cause ... Dr. Ginde says the findings suggest that current daily recommendations of vitamin D may not be enough for older adults to maintain optimal health" - See vitamin D at Amazon.com.
  • Green tea slashes heart disease death - Nutra USA, 9/8/09 - "Compared to people who drank less than one cup a day, seven or more cups of green tea a day may reduce the risk of dying from heart disease by a whopping 75 per cent ... Additionally, a reduction in the risk of colorectal cancer mortality of 31 per cent was observed for people who drank more than seven cups of green a day, compared to people who frank less than three cups a day" - [Abstract] - See green tea extract at Amazon.com.
  • Green Tea Consumption and Mortality among Japanese Elderly People: The Prospective Shizuoka Elderly Cohort - Ann Epidemiol. 2009 Oct;19(10):732-739 - "The multivariate HRs and 95% confidence intervals (CIs) for CVD mortality compared those who consumed seven or more cups per day with those who consumed less than one cup per day, were 0.24 (0.14-0.40), 0.30 (0.15-0.61), and 0.18 (0.08-0.40) for total participants, men, and women, respectively. Although green tea consumption was not inversely associated with cancer mortality, green tea consumption and colorectal cancer mortality were inversely associated with a moderate dose-response relationship" - See green tea extract at Amazon.com.
  • How Much Omega-3 Fatty Acid Do We Need To Prevent Cardiovascular Disease? - Science Daily, 9/1/09 - "a 200 mg dose of DHA per day is enough to affect biochemical markers that reliably predict cardiovascular problems, such as those related to aging, atherosclerosis, and diabetes. This study is the first to identify how much DHA is necessary to promote optimal heart health" - See Jarrow Max DHA at Amazon.com.
  • Why Low Vitamin D Raises Heart Disease Risks In Diabetics - Science Daily, 8/21/09 - "Low levels of vitamin D are known to nearly double the risk of cardiovascular disease in patients with diabetes ... When people are deficient in vitamin D, the macrophage cells eat more cholesterol, and they can't get rid of it. The macrophages get clogged with cholesterol and become what scientists call foam cells, which are one of the earliest markers of atherosclerosis" - See vitamin D at Amazon.com.
  • Resveratrol prevents hyperglycemia-induced endothelial dysfunction via activation of adenosine monophosphate-activated protein kinase - Biochem Biophys Res Commun. 2009 Aug 7 - "Endothelial dysfunction secondary to persistent hyperglycemia plays a key role in the development of type 2 diabetic vascular disease ... These results provide new insight into the protective properties of resveratrol against endothelial dysfunction caused by high glucose, which is attributed to the AMPK mediated reduction of superoxide level" - Click here for a definition of endothelial dysfunction.  See resveratrol products at Amazon.com.
  • Omega-3 polyunsaturated fatty acids and cardiovascular diseases - J Am Coll Cardiol. 2009 Aug 11;54(7):585-94 - "The most compelling evidence for CV benefits of omega-3 PUFA comes from 4 controlled trials of nearly 40,000 participants randomized to receive eicosapentaenoic acid (EPA) with or without docosahexaenoic acid (DHA) in studies of patients in primary prevention, after myocardial infarction, and most recently, with heart failure (HF) ... The target EPA + DHA consumption should be at least 500 mg/day for individuals without underlying overt CV disease and at least 800 to 1,000 mg/day for individuals with known coronary heart disease and HF" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity - Diabet Med. 2009 May;26(5):526-31 - "GSE significantly improved markers of inflammation and glycaemia and a sole marker of oxidative stress in obese Type 2 diabetic subjects at high risk of cardiovascular events over a 4-week period, which suggests it may have a therapeutic role in decreasing cardiovascular risk" - See grape seed extract at Amazon.com.
  • Daily Omega-3s Recommended for Heart - WebMD, 8/3/09 - "omega-3 fatty acids' strongest protective effect appears to be in people with established heart disease after a heart attack. In these people, a daily dose of DHA and EPA is associated with a 30% reduction in the risk of heart-related death ... But researchers say healthy people can also benefit from including omega-3s in their diet. Research shows a diet rich in omega-3s can also reduce the risk of hardening of the arteries (atherosclerosis), irregular heartbeat (arrhythmia), heart attack, sudden cardiac death, and heart failure" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects - Am J Clin Nutr. 2009 Jul 29 - "Anthocyanin consumption increased HDL-cholesterol concentrations (13.7% and 2.8% in the anthocyanin and placebo groups, respectively; P < 0.001) and decreased LDL-cholesterol concentrations (13.6% and -0.6% in the anthocyanin and placebo groups, respectively; P < 0.001). The cellular cholesterol efflux to serum increased more in the anthocyanin group than in the placebo group (20.0% and 0.2%, respectively; P < 0.001). Anthocyanin supplementation decreased the mass and activity of plasma cholesteryl ester transfer protein (CETP) (10.4% and 6.3% in the anthocyanin group and -3.5% and 1.1% in the placebo group, respectively; P < 0.001)" - See blueberry extract at Amazon.com and bilberry at Amazon.com.
  • Influence of conjugated linoleic acids on functional properties of vascular cells - Br J Nutr. 2009 Jul 22:1-18 - "Based on these studies, it can be concluded that CLA exert several beneficial actions in cells of the vascular wall through the activation of nuclear PPAR. These actions of CLA, which may, at least partially, explain the inhibition of atherogenesis by dietary CLA, include modulation of vasoactive mediator release from endothelial cells, inhibition of inflammatory and fibrotic processes in activated smooth muscle cells, abrogation of inflammatory responses in activated macrophages, and reduction of cholesterol accumulation in macrophage-derived foam cells" - See conjugated linoleic acid at Amazon.com.
  • Ameliorating Hypertension and Insulin Resistance in Subjects at Increased Cardiovascular Risk. Effects of Acetyl-L-Carnitine Therapy - Hypertension. 2009 Jul 20 - "glucose disposal rate (GDR) ... Systolic blood pressure decreased from 144.0+/-13.6 to 135.1+/-8.4 mm Hg and from 130.8+/-12.4 to 123.8+/-10.8 mm Hg in the lower and higher GDR groups, respectively (P<0.05 for both; P<0.001 overall) and progressively recovered toward baseline over 8 weeks posttreatment. Total and high molecular weight adiponectin levels followed specular trends. Diastolic blood pressure significantly decreased only in those with higher GDRs. Treatment was well tolerated in all of the patients. Acetyl-L-carnitine safely ameliorated arterial hypertension, insulin resistance, impaired glucose tolerance, and hypoadiponectinemia in subjects at increased cardiovascular risk" - See acetyl l-carnitine products at Amazon.com.
  • Daily Glass of Orange Juice Is Heart Smart - WebMD, 7/20/09 - "An antioxidant in orange juice called hesperidin improves blood vessel function and helps lower a person’s risk of heart disease ... An antioxidant in orange juice called hesperidin improves blood vessel function and helps lower a person’s risk of heart disease" - See hesperidin at Amazon.com or Natural Balance, Great Legs, 60 Capsules at iHerb.
  • Curcumin May Prevent Clogged Arteries - WebMD, 7/20/09 - "The current study suggests curcumin may thwart the development of atherosclerosis, or clogged arteries, a key risk factor for heart attacks and strokes ... Researchers in France fed 20 mice a diet supplemented with curcumin or a comparison diet not supplemented with curcumin. After 16 weeks, mice fed on the curcumin-based diet had a 26% reduction in fatty deposits in their arteries compared to mice on the comparison diet ... In addition, curcumin appeared to alter the genetic signaling involved in plaque buildup at the molecular level" - See curcumin products at Amazon.com.
  • Fish Oil and Heart Health - J Cardiovasc Pharmacol. 2009 Jun 26 - "Large controlled trials have shown that intake of fish oil (marine n-3 fatty acids, eicosapentaenoic acid, and docosahexaenoic acid), whether from dietary sources or fish oil supplements, may exhibit beneficial effects on total and cardiovascular disease mortality. Stabilization of cell membranes and suppression of cardiac arrhythmias have been identified as possible mechanisms. Moreover, n-3 fatty acids have anti-inflammatory effects, reduce blood pressure, and may also be antiatherogenic. Finally, high doses of n-3 fatty acids can lower elevated serum triglyceride levels. The n-3 index (erythrocyte eicosapentaenoic acid plus docosahexaenoic acid) may be considered as a potential risk marker for coronary heart disease mortality, especially sudden cardiac death. The balance of n-6 to n-3 fatty acids is an important determinant in decreasing the risk for coronary heart disease, both in the primary and in the secondary prevention of coronary heart disease. Patients with known coronary heart disease should be recommended to consume n-3 fatty acid supplements at 1 g per day, without raising concerns for interactions with other medications or side effects. On the other hand, fish in the diet (preferably oily fish, 1-2 meals/week) should be considered as part of a healthy diet low in saturated fat"
  • A new insight into resveratrol as an atheroprotective compound: Inhibition of lipid peroxidation and enhancement of cholesterol efflux - Atherosclerosis. 2009 May 22 - "Resveratrol thus appears to be a natural antioxidant that enhances cholesterol efflux. These properties make it a potential natural antioxidant that could be used to prevent and treat CVD" - See resveratrol products at Amazon.com.
  • Prospective Study of Serum 25-Hydroxyvitamin D Level, Cardiovascular Disease Mortality, and All-Cause Mortality in Older U.S. Adults - J Am Geriatr Soc. 2009 Jun 22 - "In noninstitutionalized older adults, a group at high risk for all-cause mortality, serum 25(OH)D levels had an independent, inverse association with CVD and all-cause mortality" - See vitamin D at Amazon.com.
  • High Carbohydrate Foods Can Cause Heart Attacks - Science Daily, 6/25/09 - "Doctors have known for decades that foods like white bread and corn flakes aren't good for cardiac health ... foods with a high glycemic index distended brachial arteries for several hours ... Enormous peaks indicating arterial stress were found in the high glycemic index groups: the cornflakes and sugar group ... During the consumption of foods high in sugar, there appears to be a temporary and sudden dysfunction in the endothelial walls of the arteries ... Endothelial health can be traced back to almost every disorder and disease in the body. It is "the riskiest of the risk factors,""
  • Low HDL-cholesterol is associated with the risk of stroke in elderly diabetic individuals: Changes in the risk for atherosclerotic diseases at various ages - Diabetes Care. 2009 Jun 9 - "IHD and CVD occurred in 1.59% and 1.43% of participants over 2-year period. The relation of lower HDL-cholesterol and/or higher LDL-cholesterol to occurrence of IHD in subjects<65 y.o. was significant. Lower HDL-cholesterol was also significantly related to CVD in subjects >=65y.o. and especially those>=75 y.o. (n=1016; odds ratio, 0.511*; 95%CI, 0.239- 0.918, *P<0.05). Stepwise multiple regression analysis with onset of CVD as a dependent variable showed same result. Conclusion: Lower HDL-cholesterol is an important risk factor for not only IHD but also CVD, especially in the diabetic elderly" - See niacin at Amazon.com (niacin increases HDL).
  • Red-wine Polyphenol Called Resveratrol Demonstrates Significant Health Benefits - Science Daily, 6/11/09 - "The breadth of benefits is remarkable – cancer prevention, protection of the heart and brain from damage, reducing age-related diseases such as inflammation, reversing diabetes and obesity, and many more ... Resveratrol exhibits therapeutic potential for cancer chemoprevention as well as cardioprotection ... The simplest explanation is that resveratrol turns on the cell's own survival pathways, preventing damage to individual cells ... Further mechanisms help, including removing very reactive oxidants in the body and improving blood supply to cells ... Low doses of resveratrol improve cell survival as a mechanism of cardio- and neuro-protection, while high doses increase cell death" - See resveratrol products at Amazon.com.
  • Can Omega-3 Fatty Acids Prevent Depression In Coronary Heart Disease? - Science Daily, 6/9/09 - "The prevalence of depression ranged from 23% in participants in the lowest tertile of omega –3 fatty acids (< 3.1% of total blood fatty acids) to 13% in participants in the highest tertile ( >4.3% of total blood fatty acids; p for trend = 0.004). Each unit decrease in EPA + DHA was inversely associated with depressive symptoms as a continuous variable, and these associations persisted after adjustment for age, sex and race. Similarly, each SD decrease in EPA + DHA was associated with significantly greater odds of depression as a dichotomous variable (Patient Health Questionnaire score >10)" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Ignored cholesterol blamed for heart attacks - MSNBC, 6/9/09 - "Statins — taken by millions to cut heart attack and stroke risk — do not affect lipoprotein (a) ... people with the highest liporotein (a) levels were two to three times more likely to have a heart attack than those with the lowest levels ... Niacin, a vitamin often prescribed generically to lower cholesterol, also lowers lipoprotein (a) levels. It can cause uncomfortable flushing, however. Aspirin can also lower lipoprotein (a) levels" - [WebMD]
  • CoQ10 Improves Endothelial Dysfunction in Statin-Treated Type 2 Diabetics - Medscape, 5/29/09 - "Study subjects were randomized to receive either 200 mg/day of oral CoQ10 or placebo for 12 weeks ... Our absolute improvement in FMD of 1% with CoQ10 supplementation may potentially translate to a 10-25% reduction in residual cardiovascular risk in these patients" - See ubiquinol products at Amazon.com.
  • Suppressive effect of EPA on the incidence of coronary events in hypercholesterolemia with impaired glucose metabolism: Sub-analysis of the Japan EPA Lipid Intervention Study (JELIS) - Atherosclerosis. 2009 Apr 5 - "investigated the effects of eicosapentaenoic acid (EPA) on coronary artery disease (CAD) ... impaired glucose metabolism (IGM) and normoglycemic (NG) patients ... Compared to NG patients, IGM patients had a significantly higher CAD hazard ratio (1.71 in the non-EPA group and 1.63 in the EPA group). The treatment with EPA resulted in a 22% decrease in the CAD incidence (P=0.048) in IGM patients and an 18% decrease (P=0.062) in NG patients" - See Mega Twin EPA at Amazon.com.
  • Eating Fatty Fish And Marine Omega-3 Fatty Acids May Reduce Risk Of Heart Failure - Science Daily, 4/28/09 - "men who consumed approximately 0.36 grams a day were 33% less likely to develop heart failure than men who consumed little or no marine omega-3 fatty acids"
  • Vitamin K supplementation and progression of coronary artery calcium in older men and women - Am J Clin Nutr. 2009 Apr 22 - "those who received phylloquinone supplements had 6% less progression than did those who received the multivitamin alone ... Phylloquinone supplementation slows the progression of CAC in healthy older adults with preexisting CAC, independent of its effect on total MGP concentrations"
  • Benefit Of Grapes May Be More Than Skin Deep: Lower Blood Pressure, Reduced Heart Damage - Science Daily, 4/22/09 - "After 18 weeks, the rats that received the grape-enriched diet powder had lower blood pressure, better heart function, and fewer signs of heart muscle damage than the rats that ate the same salty diet but didn't receive grapes ... Rats that received the blood pressure medicine, hydrazine, along with a salty diet also had lower blood pressure, but their hearts were not protected from damage as they were in the grape-fed group" - See grape seed extract at Amazon.com.
  • Fatty Fish May Lower Heart Failure Risk - WebMD, 4/22/09 - "Study participants who got the equivalent of 0.36 grams of omega-3 a day from fish had a 33% reduction in heart failure risk"
  • Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis - Hypertens Res. 2009 Apr 17 - "Resveratrol significantly attenuated Ang II-induced IL-6 mRNA expression and IL-6 protein in the supernatant of VSMC in a dose-dependent manner. Resveratrol suppressed the IL-6 gene promoter activity. Resveratrol inhibited the Ang II-induced cAMP-response element-binding protein and nuclear factor-kappa B activity, which are critical for Ang II-induced IL-6 gene activation. An increase in the serum concentration of IL-6 induced by Ang II infusion was attenuated by an oral administration of resveratrol. Resveratrol also inhibited Ang II-induced hypertension and perivascular fibrosis of the heart. Although hydralazine reduced blood pressure level equal to resveratrol, it did not reduce the Ang II-induced IL-6 production and perivascular fibrosis. These data suggest that the inhibition of Ang II-induced vascular inflammation and high blood pressure by resveratrol may contribute, at least in part, to the anti-atherogenic effects of resveratrol" - See resveratrol products at Amazon.com.
  • The More Oral Bacteria, The Higher The Risk Of Heart Attack, Study Shows - Science Daily, 4/1/09 - "two oral pathogens in the mouth were associated with an increased risk of having a heart attack, but that the total number of germs, regardless of type, was more important to heart health"
  • Late Bedtimes Linked to Heart Disease - WebMD, 3/30/09 - "The fewer hours a man slept each night, the higher his BMI, blood pressure, and triglyceride levels"
  • Red blood cell membrane alpha-linolenic acid and the risk of sudden cardiac arrest - Metabolism. 2009 Apr;58(4):534-40 - "Higher levels of long-chain n-3 polyunsaturated fatty acids in red blood cell membranes are associated with lower risk of sudden cardiac arrest. Whether membrane levels of alpha-linolenic acid, a medium-chain n-3 polyunsaturated fatty acid, show a similar association is unclear ... Higher membrane alpha-linolenic acid was associated with a higher risk of sudden cardiac arrest: after adjustment for matching factors and smoking, diabetes, hypertension, education, physical activity, weight, height, and total fat intake, the odds ratios corresponding to increasing quartiles of alpha-linolenic acid were 1.7 (95% confidence interval [CI], 1.0-3.0), 1.9 (95% CI, 1.1-3.3), and 2.5 (95% CI, 1.3-4.8) compared with the lowest quartile. The association was independent of red blood cell levels of long-chain n-3 fatty acids, trans-fatty acids, and linoleic acid. Higher membrane levels of alpha-linolenic acid are associated with higher risk of sudden cardiac arrest" - Note:  Alpha-linolenic acid (a medium-chain n-3 polyunsaturated fatty acid) is the omega-3 found in vegetable sources such as flaxseed as opposed to the eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) forms (long-chain n-3 polyunsaturated fatty acids) found in fish oils.
  • The response of gamma vitamin E to varying dosages of alpha vitamin E plus vitamin C - Metabolism. 2009 Apr;58(4):469-78 - "vitamin E has several isomers, with the alpha form being available via dietary supplements and the gamma form being available via dietary foodstuffs. The gamma form of vitamin E demonstrates several superior properties (such as trapping reactive nitrogen species and detoxifying nitrogen dioxide) compared with alpha vitamin E. All clinical trials have used the alpha isomer, with little concern that this isomer of vitamin E may actually suppress the gamma isomer of vitamin E ... The results demonstrate that alpha vitamin E levels increased in proportion to the dose administered. However, at every dose of alpha vitamin E, gamma vitamin E concentration was significantly suppressed ... Our results suggest that all prospective cardiovascular clinical trials that used vitamin E supplementation actually suppressed the beneficial antioxidant gamma isomer of vitamin E" - Dah!!  I've been saying that for years.  They're finally catching on.  See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Fruit and vegetable consumption and risk factors for cardiovascular disease - Metabolism. 2009 Apr;58(4):460-8 - "Consumption of fruits and vegetables is associated with lower concentrations of total and low-density lipoprotein cholesterol and with the risk of CVD per se in a dose-response manner"
  • Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1 - Circulation. 2009 Mar 16 - "Our data identify a molecular mechanism in the cardiomyocyte involving the oxidative stress-derived lipid peroxidation byproduct HNE and the LKB1/AMPK signaling pathway that contributes to the development of left ventricular hypertrophy. We also suggest that resveratrol may be a potential therapy for patients at risk for developing pathological cardiac hypertrophy by preventing this prohypertrophic process" - See resveratrol products at Amazon.com.
  • Consuming A Little Less Salt Could Mean Fewer Deaths - Science Daily, 3/11/09 - "A 3-gram–a-day reduction in salt intake (about 1200 mg of sodium) would result in 6 percent fewer cases of new heart disease, 8 percent fewer heart attacks, and 3 percent fewer deaths ... Currently, Americans eat 9-12 grams of salt per day"
  • Catechin prevents endothelial dysfunction in the prediabetic stage of OLETF rats by reducing vascular NADPH oxidase activity and expression - Atherosclerosis. 2009 Feb 3 - "studies have indicated that regular intake of green tea reduces the risk of cardiovascular diseases. This study examined whether catechin prevents endothelial dysfunction and hyperglycemia in the prediabetic stage of a type 2 diabetic (T2D) rat ... Catechin significantly reduced blood pressure (OLETF vs. Catechin-OLETF; 138+/-16mmHg vs. 126+/-16mmHg, p=0.013), fasting sugar (129+/-11mg/dL vs. 118+/-9mg/dL, p=0.02) and the insulin level (2.13+/-1.29ng/mL vs. 0.53+/-0.27ng/mL, p=0.004). In the aorta of Catechin-OLETF at 25 weeks, endothelium-dependent relaxations were significantly improved and NADPH oxidase activity in aortic rings was markedly decreased compared with those of OLETF. Catechin reduced vascular reactive oxygen species formation in the aorta and suppressed the expression of p22phox and p47phox NADPH oxidase subunits" - See green tea extract at Amazon.com.
  • Coffee consumption and mortality after acute myocardial infarction: The Stockholm Heart Epidemiology Program - Am Heart J. 2009 Mar;157(3):495-501 - "Self-reported coffee consumption at the time of hospitalization for myocardial infarction was inversely associated with subsequent postinfarction mortality in this population with broad coffee intake"
  • Sweetened beverage consumption and risk of coronary heart disease in women - Am J Clin Nutr. 2009 Feb 11 - "sugar-sweetened beverages (SSBs) ... After standard and dietary risk factors were adjusted for, the RRs (and 95% CIs) of CHD according to categories of cumulative average of SSB consumption (<1/mo, 1-4/mo, 2-6/wk, 1/d, and >/=2 servings/d) were 1.0, 0.96 (0.87, 1.06), 1.04 (0.95, 1.14), 1.23 (1.06, 1.43), and 1.35 (1.07, 1.69)"
  • Vitamin K2, but not K1, effective for heart health benefits: Study - Nutra USA, 2/12/09 - "This study confirms our findings in the Rotterdam study, showing that increased vitamin K2 intake strongly reduces the risk of coronary heart disease" - [Abstract] - See vitamin K at Amazon.com.
  • A high menaquinone reduces the incidence of coronary heart disease in women - Nutr Metab Cardiovasc Dis. 2009 Jan 27 - "A high intake of menoquinones, especially MK-7, MK-8 and MK-9, could protect against CHD" - See vitamin K at Amazon.com.
  • Novel Benefits Of Fatty Acids In Arteries Shown - Science Daily, 2/11/09 - "a diet rich in fish oils can prevent the accumulation of fat in the aorta, the main artery leaving the heart. The beneficial actions of fish oil that block cholesterol buildup in arteries are even found at high fat intakes ... the fatty acids contained in fish oil markedly inhibit the entry of "bad," or LDL, cholesterol into arteries and, as a result, much less cholesterol collects in these vessels ... Dr. Deckelbaum advises those interested in increasing omega-3 intakes do so by either increasing fish intake or by using supplements that contain the "long-chain" fatty acids, EPA and DHA, which are found in cold water fish" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Novel Benefits Of Fatty Acids In Arteries Shown - Science Daily, 2/5/09 - "Now, a CUMC research team led by Richard J. Deckelbaum, M.D., Director of the Columbia Institute of Human Nutrition, has found that a diet rich in fish oils can prevent the accumulation of fat in the aorta, the main artery leaving the heart. The beneficial actions of fish oil that block cholesterol buildup in arteries are even found at high fat intakes" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Salt May Restrict Blood Flow to Heart - WebMD, 1/22/09 - "Overweight and obese study participants with normal blood pressure who restricted the sodium in their diets showed evidence of improved endothelial function compared to participants who did not restrict salt ... The improvement appeared to be unrelated to the impact on blood pressure, suggesting that salt restriction is independently protective of blood vessel function"
  • Red Rice Yeast for Cholesterol Control? - Dr. Weil, 1/22/09 - "Of all the natural supplements available to help lower cholesterol, red rice yeast extracts are by far the most effective" - See red yeast rice at Amazon.com.
  • High-Dose B Vitamin Supplementation and Progression of Subclinical Atherosclerosis. A Randomized Controlled Trial - Stroke. 2008 Dec 31 - "high-dose B vitamin supplementation (5 mg folic acid+0.4 mg vitamin B12+50 mg vitamin B6) or matching placebo for 3.1 years ... High-dose B vitamin supplementation significantly reduces progression of early-stage subclinical atherosclerosis (carotid artery intima media thickness) in well-nourished healthy B vitamin "replete" individuals at low risk for cardiovascular disease with a fasting tHcy >/=9.1 micromol/L"
  • Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells - Atherosclerosis. 2008 Nov 24 - "Smooth muscle cell (SMC) proliferation is a major feature in atherosclerosis, since it contributes to the formation of the fibrous cap, thus to plaque stability, but also to arterial stenosis and post-angioplasty restenosis ... These data indicate that the mTOR pathway is activated by oxLDL via PI3K/PDK1/Akt, and is required for SMC proliferation. Resveratrol blocks specifically this pathway, thereby inhibiting oxLDL-induced SMC proliferation. These data highlight a new property for resveratrol that could contribute to the general anti-atherogenic properties of this polyphenol" - See resveratrol products at Amazon.com.
  • Go ahead, sleep in — it’s good for the heart - msnbc.com, 12/23/08 - "About 12 percent of the people in the study developed artery calcification during the five-year study period. Among those who had slept less than five hours a night, 27 percent had developed artery calcification ... That dropped to 11 percent among those who slept five to seven hours, and to 6 percent among those who slept more than seven hours a night"
  • Inflamed Gums Linked To Heart Disease - Science Daily, 12/20/08 - "a protein associated with inflammation (called CRP) is elevated in people who are at risk for heart disease. But where's the inflammation coming from? ... infected gums may be one place ... something as simple as taking good care of your teeth and gums can greatly reduce your risk of developing serious diseases"
  • Vitamin D Deficiency Increases Risk of Cardiovascular Disease - Doctor's Guide, 12/10/08 - "a review article published in the December 9 issue of the Journal of the American College of Cardiology ... patients with vitamin D levels below 15 ng/mL were twice as likely to experience a heart attack, stroke, or other CV event within the next 5 years compared with those with higher levels" - See vitamin D at Amazon.com.
  • Fish consumption and risk of major chronic disease in men - Am J Clin Nutr. 2008 Dec;88(6):1618-1625 - "Compared with fish consumption of <1 serving/mo, consumption of 1 serving/wk and of 2-4 servings/wk was associated with a lower risk of total cardiovascular disease of approximately 15%" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1-FoxO1 pathway - Biochem Biophys Res Commun. 2008 Dec 3 - "Loss of cardiomyocytes through apoptosis has been proposed as a cause of ventricular remodeling and heart failure. Ischemia- and hypoxia-induced apoptosis of cardiomyocytes reportedly plays an important role in many cardiac pathologies. We investigated whether resveratrol (Res) has direct cytoprotective effects against ischemia/hypoxia for cardiomyocytes. Exposure of H9c2 embryonic rat heart-derived cells to hypoxia for 24h caused a significant increase in apoptosis, as evaluated by TUNEL and flow cytometry, while treatment with 20muM Res greatly decreased hypoxia-induced apoptosis in these cells. Exposure of the cells to Res (20muM) caused rapid activation of SIRT1, which had a dual effect on FoxO1 function: SIRT1 increased FoxO1's ability to induce cell cycle arrest, but inhibited FoxO1's ability to induce cell death. This effect could be reversed by SIRT1 inhibition. Results of our study indicate that Res inhibits hypoxia-induced apoptosis via the SIRT1-FoxO1 pathway in H9c2 cells. This polyphenol may have potential in preventing cardiovascular disease, especially in coronary artery disease (CAD) patients" - See resveratrol products at Amazon.com.
  • Vitamin D Deficiency An Important, Common, and Easily Treatable Cardiovascular Risk Factor? - J Am Coll Cardiol. 2008 Dec 9;52(24):1949-1956 - "Vitamin D deficiency is a highly prevalent condition, present in approximately 30% to 50% of the general population. A growing body of data suggests that low 25-hydroxyvitamin D levels may adversely affect cardiovascular health. Vitamin D deficiency activates the renin-angiotensin-aldosterone system and can predispose to hypertension and left ventricular hypertrophy. Additionally, vitamin D deficiency causes an increase in parathyroid hormone, which increases insulin resistance and is associated with diabetes, hypertension, inflammation, and increased cardiovascular risk. Epidemiologic studies have associated low 25-hydroxyvitamin D levels with coronary risk factors and adverse cardiovascular outcomes. Vitamin D supplementation is simple, safe, and inexpensive. Large randomized controlled trials are needed to firmly establish the relevance of vitamin D status to cardiovascular health. In the meanwhile, monitoring serum 25-hydroxyvitamin D levels and correction of vitamin D deficiency is indicated for optimization of musculoskeletal and general health" - See vitamin D at Amazon.com.
  • Effect of cranberry extracts on lipid profiles in subjects with Type 2 diabetes - Diabet Med. 2008 Dec;25(12):1473-7 - "Changes in lipid profiles, oxidized low-density lipoprotein (ox-LDL), glycaemic control, components of the metabolic syndrome, C-reactive protein (CRP) and urinary albumin excretion (UAE) were assessed after cranberry or placebo treatment for 12 weeks ... Low-density lipoprotein (LDL) cholesterol decreased significantly in the cranberry group (from 3.3 +/- 0.2 to 2.9 +/- 0.2 mmol/l, P = 0.005) and the decrease was significantly greater than that in the placebo group (-0.4 +/- 0.1 vs. 0.2 +/- 0.1 mmol/l, P < 0.001). Total cholesterol and total : high-density lipoprotein (HDL) cholesterol ratio also decreased significantly (P = 0.020 and 0.044, respectively) in the cranberry group and the reductions were significantly different from those in the placebo group (P < 0.001 and P = 0.032, respectively) ... Cranberry supplements are effective in reducing atherosclerotic cholesterol profiles, including LDL cholesterol and total cholesterol levels, as well as total : HDL cholesterol ratio, and have a neutral effect on glycaemic control in Type 2 diabetic subjects taking oral glucose-lowering agents" - See cranberry extract at Amazon.com.
  • Vitamin E Shows Possible Promise In Easing Chronic Inflammation - Science Daily, 12/4/08 - "the larger take-home message of the study, published in the December issue of the journal Experimental Physiology, is that Vitamin E “may be beneficial in individuals with chronic inflammation, such as the elderly or patients with type II diabetes or chronic heart failure" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Too Little Vitamin D Puts Heart at Risk - WebMD, 12/1/08 - "people with low vitamin D levels were twice as likely to have a heart attack, stroke, or other heart-related event during follow-up, compared with those with higher vitamin D levels ... Sunscreen with a sun protection factor (SPF) of 15 blocks approximately 99% of vitamin D synthesis by the skin ... The safe upper limit of vitamin D consumption is 10,000 IU per day ... Vitamin D supplements are available in two different forms: Vitamin D2 and Vitamin D3. Although both appear effective in raising vitamin D blood levels, Vitamin D3 supplements appear to result in a longer-lasting boost" - See vitamin D at Amazon.com.
  • Caffeinated Coffee Consumption, Cardiovascular Disease, and Heart Valve Disease in the Elderly (from the Framingham Study) - Am J Cardiol. 2008 Dec 1;102(11):1502-8. Epub 2008 Sep 11 - "A significant negative association between caffeinated coffee consumption and CHD mortality was observed for subjects with systolic blood pressure (BP) <160 mm Hg and diastolic BP <100 mm Hg. The decrease in risk of CHD mortality for any caffeinated coffee versus none was 43% (95% confidence interval 9 to 64). This decreased risk appeared to be caused primarily by an inverse prospective relation between caffeinated coffee consumption and the development or progression of heart valve disease. The decrease in risk of heart valve disease for subjects with systolic BP <160 mm Hg and diastolic BP <100 mm Hg for any caffeinated coffee versus none was 43%"
  • Higher Blood Phosphorus and Calcium Levels in Coronary Arteries - Science Daily, 11/26/08 - "Higher serum phosphorus levels, even within the normal range, may be a risk factor for coronary artery atherosclerosis in healthy young adults"
  • Coenzyme Q(10) An Independent Predictor of Mortality in Chronic Heart Failure - J Am Coll Cardiol. 2008 Oct 28;52(18):1435-1441 - "Plasma CoQ(10) concentration was an independent predictor of mortality in this cohort. The CoQ(10) deficiency might be detrimental to the long-term prognosis of CHF, and there is a rationale for controlled intervention studies with CoQ(10)" - See ubiquinol products at Amazon.com.
  • Grapes May Aid A Bunch Of Heart Risk Factors, Animal Study Finds - Science Daily, 10/29/08 - "Could eating grapes help fight high blood pressure related to a salty diet? And could grapes calm other factors that are also related to heart diseases such as heart failure? A new University of Michigan Cardiovascular Center study suggests so" - See grape seed extract at Amazon.com.
  • Grapes And Grape Extracts May Lower Cardiovascular Disease Risk, Review Article Suggests - Science Daily, 10/28/08 - "grape polyphenols work in many different ways to prevent cardiovascular and other "inflammatory-mediated" diseases. Polyphenols are natural antioxidants found in grapes and some other plant foods. Their types and actions vary, depending on where in the grape they are found. Grape seeds, grape skin, and grape juice contain several types of polyphenols, including resveratrol, phenolic acids, anthocyanins, and flavonoids" - See grape seed extract at Amazon.com.
  • Eating Whole Grains Lowers Heart Failure Risk, According To New Study - Science Daily, 10/27/08 - "whole grain consumption lowered HF risk, while egg and high-fat dairy consumption raised risk. Other food groups did not directly affect HF risk"
  • Coenzyme Q-10 Depletion Linked to Worse Heart Failure Outcomes - Medscape, 10/22/08 - "Low plasma concentration of coenzyme Q-10 is an independent predictor of reduced survival in patients with chronic heart failure" - See ubiquinol products at Amazon.com.
  • Flavonoids’ heart health benefits in the blood vessels: Study - Nutra USA, 10/10/08 - "A daily dose of quercetin or (-)-epicatechin led to improvements in endothelial function, a key marker of cardiovascular health" - [Abstract]
  • Dietary fiber intake in relation to coronary heart disease and all-cause mortality over 40 y: the Zutphen Study -  Am J Clin Nutr. 2008 Oct;88(4):1119-25 - "Every additional 10 g of recent dietary fiber intake per day reduced coronary heart disease mortality by 17% (95% CI: 2%, 30%) and all-cause mortality by 9% (0%, 18%). The strength of the association between long-term dietary fiber intake and all-cause mortality decreased from age 50 y (hazard ratio: 0.71; 95% CI: 0.55, 0.93) until age 80 y (0.99; 0.87, 1.12). We observed no clear associations for different types of dietary fiber. CONCLUSIONS: A higher recent dietary fiber intake was associated with a lower risk of both coronary heart disease and all-cause mortality. For long-term intake, the strength of the association between dietary fiber and all-cause mortality decreased with increasing age"
  • Intakes of long-chain n-3 polyunsaturated fatty acids and fish in relation to measurements of subclinical atherosclerosis - Am J Clin Nutr. 2008 Oct;88(4):1111-8 - "After adjustment for potential confounders, intakes of long-chain n-3 PUFAs and nonfried (broiled, steamed, baked, or raw) fish were inversely related to subclinical atherosclerosis determined by cCIMT but not by iCIMT, CAC score, or ABI. The multivariate odds ratio comparing the highest to the lowest quartile of dietary exposures in relation to subclinical atherosclerosis determined by cCIMT was 0.69 (95% CI: 0.55, 0.86; P for trend < 0.01) for n-3 PUFA intake; 0.80 (95% CI: 0.64, 1.01; P = 0.054) for nonfried fish consumption; and 0.90 (95% CI: 0.73, 1.11; P = 0.38) for fried fish consumption" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Pure dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men - Am J Clin Nutr. 2008 Oct;88(4):1018-25 - "Dietary flavonoids, such as quercetin and (-)-epicatechin, can augment nitric oxide status and reduce endothelin-1 concentrations and may thereby improve endothelial function"
  • Increasing dietary fish intake has contributed to decreasing mortality from CHD among the older population in Hong Kong - Public Health Nutr. 2008 Oct 7:1-6 - "The time trend of CHD mortality was inversely related to the trend of fish intake. The frequency of fish intake may have a substantial impact on the population for the prevention of CHD deaths in Hong Kong" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Green tea and cardiovascular disease: from molecular targets towards human health - Curr Opin Clin Nutr Metab Care. 2008 Nov;11(6):758-65 - "Consumption of green tea has been inversely associated with the development and progression of cardiovascular diseases and cardiovascular risk factors. Mechanisms that have been suggested as being involved in the antiatherosclerotic effects of green tea consumption primarily entail antioxidative, antiinflammatory, antiproliferative, and antithrombotic properties, as well as beneficial effects on endothelial function. Moreover, evidence exists for myocardial effects of tea constituents, including positive inotropic and antihypertrophic effects, and beneficial impact in myocardial ischaemia-reperfusion injury" - See green tea extract at Amazon.com.
  • Fish, omega-3 Polyunsaturated Fatty Acids, and Mortality From Cardiovascular Diseases in a Nationwide Community-Based Cohort of Japanese Men and Women The JACC (Japan Collaborative Cohort Study for Evaluation of Cancer Risk) Study - J Am Coll Cardiol. 2008 Sep 16;52(12):988-996 - "For mortality from total cardiovascular disease, intakes of fish and omega-3 PUFA were associated with 18% to 19% lower risk ... We found an inverse association between fish and omega-3 PUFA dietary intakes and cardiovascular mortality, especially for heart failure, suggesting a protective effect of fish intake on cardiovascular diseases" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals - Atherosclerosis. 2008 Sep 27 - "The combination of n-3 PUFA and plant sterols reduced several inflammatory markers. High sensitivity C-reactive protein (hs-CRP) was reduced by 39% (P=0.009), tumor necrosis factor-alpha (TNF-alpha) by 10% (P=0.02), interleukin-6 (IL-6) by 10.7% (P=0.009), leukotriene B(4) (LTB(4)) by 29.5% (P=0.01) and adiponectin was increased by 29.5% (P=0.05). Overall cardiovascular risk was reduced by 22.6% (P=0.006) in the combination group. CONCLUSION: We have demonstrated, for the first time that dietary intervention with n-3 PUFA and plant sterols reduces systemic inflammation in hyperlipidemic individuals. Furthermore, our results suggest that reducing inflammation provides a potential mechanism by which the combination of n-3 PUFA and plant sterols are cardioprotective" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Bleeding Gums Linked To Heart Disease - Science Daily, 9/10/08 - "People with poor dental hygiene and those who don't brush their teeth regularly end up with bleeding gums, which provide an entry to the bloodstream for up to 700 different types of bacteria found in our mouths. This increases the risk of having a heart attack"
  • Vitamin K2 linked to better heart health - NutraUSA, 9/10/08 - "When the intakes of K1 and K2 were divided into four groups from the lowest to highest, no association was found between K1 intakes and calcification. However, high consumption of K2 (about 45 micrograms per day) was associated with 20 per cent decreased coronary calcification, compared with low consumption of K2 (about 18micrograms per day)" - See Vitamin K products at iHerb.
  • Omega-3 Fatty Acids, but Not Statin Therapy, Cuts Mortality and Hospitalizations in Heart Failure - Medscape, 9/3/08 - "Speaking to the media, Tavazzi said the advantage of n-3 PUFA, as documented by the primary end points, is that they appear to have a beneficial effect on the mechanisms leading to the progression of heart failure. Although the exact reasons are unknown, omega-3 fatty acids could possibly exert favorable effects on inflammatory processes, such as reductions in endothelial activation and cytokine production, as well as influence platelet aggregation, blood pressure, heart rate, ventricular function, and autonomic tone" - See Mega Twin EPA at Amazon.com.
  • Effects Of N-3 PUFA In Patients With Symptomatic Chronic Heart Failure: The GISSI-HF Results - Science Daily, 8/31/08 - "undertook a randomised, double blind, placebo controlled trial in 357 cardiology sites in Italy. They enrolled 6 975 patients with chronic heart failure of New York Heart Association class II-IV, assigned to n-3 PUFA 1 g daily or placebo. Patients were followed up for a median of 3•9 years ... In a per-protocol analysis performed in about 5000 full complier patients, the relative risk of death was reduced by 14% (p 0.004). Safety was excellent" - See Mega Twin EPA at Amazon.com.
  • Fish oil helps patients with chronic heart failure - MSNBC, 8/31/08 - "Comparing the results from both studies, the researchers concluded that fish oil is slightly more effective than the drug because the oil performed better against a placebo than did Crestor ... Both studies were paid for by an Italian group of pharmaceuticals including Pfizer Inc., Sigma Tau SpA and AstraZeneca PLC" - See Mega Twin EPA at Amazon.com.
  • Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide production - J Nutr. 2008 Sep;138(9):1602-8 - "resveratrol, at concentrations attainable after moderate wine intake, activates platelet eNOS and in this way blunts the proinflammatory pathway linked to p38MAPK, thus inhibiting ROS production and ultimately platelet function. This activity may contribute to the beneficial effects of moderate wine intake on ischemic cardiovascular disease" - See resveratrol products at Amazon.com.
  • Coffee consumption and risk of coronary heart diseases: A meta-analysis of 21 prospective cohort studies - Int J Cardiol. 2008 Aug 14 - "Our findings do not support the hypothesis that coffee consumption increases the long-term risk of coronary heart disease. Habitual moderate coffee drinking was associated with a lower risk of CHD in women"
  • Green tea reduces LDL oxidability and improves vascular function - J Am Coll Nutr. 2008 Apr;27(2):209-13 - "The mean diameter of the brachial artery following the post-compression hyperaemia phase rose significantly (p < 0.0001) after treatment with green tea extract. Flow-mediated brachial artery vasodilation ranged from 5.68% for the placebo phase to 11.98% after the green tea extract (p = 0.02). The consumption of green tea extract was associated with a significant 37.4% reduction in the concentration of oxidized LDL (TBARS) (p = 0.017). The levels of anti-oxidized LDL IgM antibodies fell significantly after treatment (p = 0.002) ... This study found that consumption of green tea extract by women for five weeks produced modifications in vascular function and an important decrease in serum oxidizability" - See green tea extract at Amazon.com.
  • Low Vitamin D Levels Pose Large Threat To Health; Overall 26 Percent Increased Risk Of Death - Science Daily, 8/12/08 - "This translates overall to an estimated 26 percent increased risk of any death, though the number of deaths from heart disease alone was not large enough to meet scientific criteria to resolve that it was due to low vitamin D levels ... Previous results from the same nationwide survey showed that 41 percent of men and 53 percent of women are technically deficient in the nutrient, with vitamin D levels below 28 nanograms per milliliter" - See vitamin D at Amazon.com.
  • Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography - J Clin Endocrinol Metab. 2008 Aug 5 - "sudden cardiac death (SCD) ... Low levels of 25(OH)D and 1,25(OH)2D are associated with prevalent myocardial dysfunction, deaths due to heart failure and SCD" - See vitamin D at Amazon.com.
  • Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: Sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS) - Atherosclerosis. 2008 Jun 19 - "Multiple risk factors besides cholesterol are associated with markedly increased incidence of CAD. High TG with low HDL-C represents a particularly potent risk factor. EPA was effective in reducing the incidence of CAD events for patients with this dyslipidemic pattern, suggesting that EPA may be especially beneficial in patients who with abnormal TG and HDL-C levels" - See Mega Twin EPA at Amazon.com.
  • Exercise Could Be The Heart's Fountain Of Youth - Science Daily, 7/23/08 - "Absence may make the heart grow fonder, but endurance exercise seems to make it younger ... older people who did endurance exercise training for about a year ended up with metabolically much younger hearts ... after endurance exercise training -- which involved walking, running or cycling exercises three to five days a week for about an hour per session -- the participants' hearts doubled their glucose uptake during high-energy demand"
  • Long-term fish consumption and n-3 fatty acid intake in relation to (sudden) coronary heart disease death: the Zutphen study - Eur Heart J. 2008 Jul 18 - "long-term fatty-fish consumption lowered the risk of sudden coronary death [HR: 0.46" - See Mega Twin EPA at Amazon.com.
  • Alpha-linolenic acid reduces risk of nonfatal MI - theheart.org, 7/9/08 - "ALA is an intermediate-chain n-3 polyunsaturated fatty acid that is often overshadowed by the more famous long-chain members of the n-3 family, namely EPA and DHA acids that are found in fish oils ... ALA intake, g/day ... 1.79 ... Relative risk of MI ... 0.43 ... The relationship between ALA and myocardial infarction was nonlinear ... We see a dose effect, but only up to about 0.7% of adipose tissue, which corresponds to about 1.8 g/day. Increasing intake further was not associated with increased protection" - See flax seed at Amazon.com.
  • Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice - Biochem Biophys Res Commun. 2008 Jul 5 - "The concentration of total-cholesterol (total-C) and LDL-cholesterol (LDL-C) in plasma was significantly lower in the resveratrol-supplemented groups compare to the control group over the entire experimental period. The plasma HDL-C concentration was significantly elevated, and the ratio of HDL-C/total-C was significantly higher in the CF and RV groups than in the control group. Plasma paraoxonase (PON) activity was significantly higher in the 0.06% resveratrol group. The hepatic HMG-CoA reductase (HMGR) activity was significantly lower in the clofibrate and resveratrol groups than in the control group. Resveratrol supplements attenuated the presence of atherosclerotic lesions and periarterial fat deposition in the apo E(-/-) mice. The presence of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in atherosclerotic vessels was diminished in the resveratrol-supplemented apo E(-/-) mice. These results provide new insight into the anti-atherogenic and hypocholesterolemic properties of resveratrol in apo E(-/-) mice that were fed a normal diet" - See resveratrol products at Amazon.com.
  • Green tea's heart benefits gain support - Nutra USA, 7/7/08 - "Regular consumption of green tea may improve the function of endothelial cells - cells lining the walls of blood vessels - and boost cardiovascular health, according to new research from Greece" - [Abstract] - See green tea extract at Amazon.com.
  • The acute effect of green tea consumption on endothelial function in healthy individuals - Eur J Cardiovasc Prev Rehabil. 2008 Jun;15(3):300-5 - "Flow-mediated dilatation (FMD) ... FMD increased significantly with tea (by 3.69%, peak at 30 min, P<0.02), whereas it did not change significantly with caffeine (increase by 1.72%, peak at 30 min, P=NS) ... Green tea consumption has an acute beneficial effect on endothelial function, assessed with FMD of the brachial artery, in healthy individuals. This may be involved in the beneficial effect of tea on cardiovascular risk" - See green tea extract at Amazon.com.
  • Benefits Of Green Tea In Reducing An Important Risk Factor For Heart Disease - [WebMD] - Science Daily, 7/2/08 - "More evidence for the beneficial effect of green tea on risk factors for heart disease has emerged in a new study. The study found that the consumption of green tea rapidly improves the function of (endothelial) cells lining the circulatory system; endothelial dysfunction is a key event in the progression of atherosclerosis" - See green tea extract at Amazon.com.
  • Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt - J Biol Chem. 2008 Jun 18 - "Taken together, our data suggest that resveratrol exerts anti-hypertrophic effects by activating AMPK via LKB1 and inhibiting Akt, thus suppressing protein synthesis and gene transcription" - See resveratrol products at Amazon.com.
  • Drinking Large Amounts Of Coffee May Actually Extend One's Lifespan, Study Suggests - Science Daily, 6/16/08 - "Women consuming two to three cups of caffeinated coffee per day had a 25 percent lower risk of death from heart disease during the follow-up period (which lasted from 1980 to 2004 and involved 84,214 women) as compared with non-consumers, and an 18 percent lower risk of death caused by something other than cancer or heart disease as compared with non-consumers during follow-up. For men, this level of consumption was associated with neither a higher nor a lower risk of death during the follow-up period"
  • Vitamin D: New Way To Treat Heart Failure? - Science Daily, 6/11/08 - "treatments with activated vitamin D prevented heart muscle cells from growing bigger – the condition, called hypertrophy, in which the heart becomes enlarged and overworked in people with heart failure. The treatments prevented heart muscle cells from the over-stimulation and increased contractions associated with the progression of heart failure" - See vitamin D at Amazon.com.
  • Low Vitamin D Ups Heart Risk in Men - WebMD, 6/9/08 - "men who had vitamin D levels of 15 ng/mL or less in their blood samples -- an indication of vitamin D deficiency -- had an increased risk for heart attack compared to those whose vitamin D level was considered sufficient (30 ng/mL). The twofold increased risk remained significant even when adjusting for other factors known to contribute to heart disease, such as high cholesterol, diabetes, high blood pressure, or a family history of heart disease" - See vitamin D at Amazon.com.
  • Chinese Red Yeast Rice Is Good For Your Heart, Study Suggests - Science Daily, 6/9/08 - "a partially purified extract of Chinese red yeast rice, Xuezhikang (XZK), reduced the risk of repeat heart attacks by 45%, revascularization (bypass surgery/angioplasty), cardiovascular mortality and total mortality by one-third and cancer mortality by two-thirds" - See red yeast rice at Amazon.com.
  • Low-dose resveratrol may slow ageing: for mice at least - Nutra USA, 6/4/08 - "animals in the calorie-restriction and low-dose resveratrol groups had altered gene expression profiles in 90 and 92 per cent, respectively, in the heart ... In short, a glass of wine or food or supplements that contain even small doses of resveratrol are likely to represent "a robust intervention in the retardation of cardiac ageing,"" - See resveratrol products at Amazon.com.
  • Substance In Red Wine, Resveratrol, Found To Keep Hearts Young - Science Daily, 6/4/08 - "Resveratrol is active in much lower doses than previously thought and mimics a significant fraction of the profile of caloric restriction at the gene expression level ... In animals on a restricted diet, 90 percent of those heart genes experienced altered gene expression profiles, while low doses of resveratrol thwarted age-related change in 92 percent. The new findings, say the study's authors, were associated with prevention of the decline in heart function associated with aging" - See resveratrol products at Amazon.com.
  • Cocoa for Diabetes? - WebMD, 5/27/08 - "Researchers caution that the high-dose flavonol cocoa used in their study greatly exceeds the typical U.S. dietary intake of 20 to 100 milligrams daily, and you can't buy the extra-strength version in stores. Rather, they are optimistic that flavonol-containing diets offer an innovative approach to preventing heart disease"
  • Reducing Salt Intake Can Lower the Long-Term Risk for Cardiovascular Events - Medscape, 4/24/08 - "Cutting back on salt intake, while known to lower blood pressure, also appears to significantly reduce the long-term risk of cardiovascular events. Observational follow-up from the Trials of Hypertension Prevention (TOHP) showed that a reduction in salt intake could reduce the risk of cardiovascular disease outcomes by 25%"
  • Dietary Fish Oil Has Antiarrhythmic Effects in Ischemic Heart Disease - Medscape, 4/22/08 - "This stabilizing effect may be one way in which fish oil reduces mortality in patients with coronary artery disease" - See Mega Twin EPA at Amazon.com.
  • DASH Diet Improves Women's Heart Health - WebMD, 4/14/08 - "The women who had the highest DASH scores had the lowest risk for heart disease and stroke. Closely following a DASH diet resulted in a 24% reduction in heart disease risk and 18% lower risk of stroke when compared to those with the lowest DASH scores"
  • The glycemic index and cardiovascular disease risk - Curr Atheroscler Rep. 2007 Dec;9(6):479-85 - "dietary GI and/or glycemic load independently predict cardiovascular disease, with relative risk ratios of 1.2 to 1.7 comparing highest and lowest quintiles. In randomized controlled trials in overweight subjects, diets based on low-GI carbohydrates have produced better cardiovascular-related outcomes than conventional low-fat diets. Taken together, the findings suggest that health professionals may be able to improve cardiovascular outcomes by recommending the judicious use of low- GI/glycemic load foods"
  • New evidence for the cardiovascular benefits of long chain omega-3 Fatty acids - Curr Atheroscler Rep. 2007 Dec;9(6):434-40 - "The role of long chain omega-3 fatty acids (LC n-3 FAs) as cardioprotective agents has become even clearer with the recent publication of the Japan EPA Lipid Intervention Study. This was the largest randomized controlled trial in the field, and it demonstrated that even in a population with one of the highest LC n-3 FA intakes in the world, the addition of eicosapentaenoic acid could reduce cardiac events" - See Mega Twin EPA at Amazon.com.
  • Flavonoid intake and the risk of ischaemic stroke and CVD mortality in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study - Br J Nutr. 2008 Apr 1;:1-6 - "men in the highest quartile of flavonol and flavan-3-ol intakes had a relative risk of 0.55 (95 % CI 0.31, 0.99) and 0.59 (95 % CI 0.30, 1.14) for ischaemic stroke, respectively, as compared with the lowest quartile. After multivariate adjustment, the relative risk for CVD death in the highest quartile of flavanone and flavone intakes were 0.54 (95 % CI 0.32, 0.92) and 0.65 (95 % CI 0.40, 1.05), respectively"
  • Brief, High Doses Of Folate -- B Vitamin -- Blunt Damage From Heart Attack - Science Daily, 3/27/08 - "Long known for its role in preventing anemia in expectant mothers and spinal birth defects in newborns, the B vitamin folate, found in leafy green vegetables, beans and nuts has now been shown to blunt the damaging effects of heart attack when given in short-term, high doses to test animals ... a high dose of folic acid for humans comparable to that given the rats would require an average-size adult to swallow more than 200 one-milligram pills per day, "an impractical and unrealistic regimen, even if the body excretes the excess."" - I debated whether to publish this.  It is a ridiculous amount.
  • Omega-3 Fatty Acids May Be Useful for Cardioprotection - Medscape, 3/18/08 - "To date, the strongest evidence showing a CV benefit from omega-3 fatty acid intake derives from 3 large controlled trials in which a total of 32,000 participants were randomized to a control group or to receive omega-3 fatty acid supplements containing DHA and EPA. In these trials, the supplemented group had a 19% to 45% reduction in CV events vs the control group ... Patients with hypertriglyceridemia should consume 3 to 4 g/day of DHA and EPA, which can lower triglyceride levels by 20% to 50%" - See Mega Twin EPA at Amazon.com.
  • Fish Diet May Cut Sudden Coronary Death - WebMD, 3/12/08 - "Men who reported eating an average of 6 grams of fatty fish daily -- that's two servings, according to the U.S. Department of Agriculture's serving-size guidelines -- were 55% less likely than men who ate no fatty fish to die of sudden coronary death ... The researchers chalk up the results to the omega-3 fatty acids EPA and DHA" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Resveratrol protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivo - Br J Pharmacol. 2008 Mar 10 - "The clinical use of arsenic trioxide (As(2)O(3)), a potent antineoplastic agent, is limited by its severe cardiotoxic effects ... resveratrol significantly attenuated As(2)O(3)-induced QT prolongation, structural abnormalities and oxidative damage in the heart. In H9c2 cardiomyocytes, resveratrol also decreased apoptosis, production of ROS and intracellular calcium mobilization induced by treatment with As(2)O(3). These observations suggested that resveratrol has the potential to protect against cardiotoxicity in As(2)O(3)-exposed patients" - See resveratrol products at Amazon.com.
  • Cardiovascular Benefits Of Omega-3 Fatty Acids Reviewed - Science Daily, 3/12/08 - "The most compelling evidence for the cardiovascular benefit provided by omega-3 fatty acids comes from three large controlled trials of 32,000 participants randomized to receive omega-3 fatty acid supplements containing DHA and EPA or to act as controls ... These trials showed reductions in cardiovascular events of 19 percent to 45 percent ... keeping fish oil capsules in the freezer ... may help reduce burping and upset stomach symptoms" - I've always done the freezer thing and haven't had any problem with the burp even on an empty stomach.  Also note that it's the DHA and EPA that count.  I have friends that buy cheap fish oil capsules that have very low DHA and EPA (omega-3) and they think they are getting a great deal.  I take Jarrow Max DHA at Amazon.com and Jarrow Max DHA at Amazon.com.  They've got the highest percentage of omega-3 that I've found.
  • Omega3 Fatty acids for cardioprotection - Mayo Clin Proc. 2008 Mar;83(3):324-32 - "The most compelling evidence for the cardiovascular benefit provided by omega-3 fatty acids comes from 3 large controlled trials of 32,000 participants randomized to receive omega-3 fatty acid supplements containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) or to act as controls. These trials showed reductions in cardiovascular events of 19% to 45%. These findings suggest that intake of omega-3 fatty acids, whether from dietary sources or fish oil supplements, should be increased, especially in those with or at risk for coronary artery disease. Patients should consume both DHA and EPA. The target DHA and EPA consumption levels are about 1 g/d for those with known coronary artery disease and at least 500 mg/d for those without disease. Patients with hypertriglyceridemia benefit from treatment with 3 to 4 g/d of DHA and EPA, a dosage that lowers triglyceride levels by 20% to 50%. Although 2 meals of oily fish per week can provide 400 to 500 mg/d of DHA and EPA, secondary prevention patients and those with hypertriglyceridemia must use fish oil supplements if they are to reach 1 g/d and 3 to 4 g/d of DHA and EPA, respectively" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.  I take both because the percentage of omega-3 (EPA and DHA) is very low in other supplements.  I don't know what the rest of that oil is but your not saving anything by getting supplements with a low percentage.  Just do the math plus if the rest of the oil is an omega-6 you're not helping the omega-6/omega-3 ratio.
  • Ingredient In Yellow Curry Can Reduce Heart Enlargement And May Prevent Heart Failure - Science Daily, 2/21/08 - "Eating curcumin, a natural ingredient in the spice turmeric, may dramatically reduce the chance of developing heart failure" - See curcumin products at Amazon.com.
  • Long Term N-Acetylcysteine and L-Arginine Administration Reduces Endothelial Activation and Systolic Blood Pressure in Hypertensive Patients with Type 2 Diabetes Mellitus - Diabetes Care. 2008 Feb 11 - "The NAC+ARG administration seems to be a potential well-tolerated antiatherogenic therapy since it improves the endothelial function in hypertensive patients with type 2 diabetes by improving NO bioavailability via reduction of the oxidative stress and increase of NO production. Our study's results give prominence to its potential use in the primary and secondary cardiovascular prevention in these patients"
  • Herbal Remedy, Hawthorn Extract, Can Help The Heart, Review Finds - Science Daily, 1/22/08 - "The trials involved a total of 855 patients and the data indicated that hawthorn extract: ... improved maximal workload ... increased exercise tolerance ... reduced oxygen consumption by the heart ... reduced shortness of breath and fatigue" - See hawthorn products at Amazon.com.
  • Broccoli Good for the Heart - WebMD, 1/18/08 - "The rats that had eaten the broccoli extract had three heart advantages over the other rats: ... Better blood-pumping ability ... Less heart damage during oxygen deprivation ... Higher levels of heart-health chemicals during oxygen deprivation ... Broccoli's key nutrients include selenium and sulforaphane, which may also curb cancer" - See indole-3-carbinol at Amazon.com.
  • Calcium: Heart Risk for Older Women? - WebMD, 1/15/08 - "The women in the supplement group got 861 milligrams of calcium from diet per day, on average, boosting their total daily intake to 1,861. The placebo group averaged about 853 milligrams of calcium daily from their diet ... The risk of a heart attack was about 1.5 times greater for those in the supplement group, but the link did not reach statistical significance ... the calcium supplements may elevate blood calcium levels and possibly speed calcification in blood vessels"
  • Lipoic Acid Could Reduce Atherosclerosis, Weight Gain - Science Daily, 1/14/08 - "lipoic acid supplements reduced atherosclerotic lesion formation in two types of mice that are widely used to study cardiovascular disease, by 55 percent and 40 percent, respectively. The supplements were also associated with almost 40 percent less body weight gain, and lower levels of triglycerides in very low-density lipoproteins" - See alpha lipoic acid at Amazon.com.
  • Staying Active And Drinking Moderately Is The Key To A Long Life, Study Suggests - Science Daily, 1/9/08 - "ischaemic heart disease ... People who drank at least one drink a week and were physically active had a 44-50 per cent lower risk of IHD compared to physically inactive non-drinkers"
  • The effects of a whole grain enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome - J Clin Nutr. 2008 Jan;87(1):79-90 - "Both hypocaloric diets were effective means of improving CVD risk factors with moderate weight loss. There were significantly (P < 0.05) greater decreases in CRP and percentage body fat in the abdominal region in participants consuming whole grains than in those consuming refined grains"
  • Lack Of Vitamin D May Increase Heart Disease Risk - Science Daily, 1/7/08 - "those with blood levels of vitamin D below15 nanograms per milliliter (ng/mL) had twice the risk of a cardiovascular event such as a heart attack, heart failure or stroke in the next five years compared to those with higher levels of vitamin D ... Overall, 28 percent of individuals had levels of vitamin D below15 ng/mL and 9 percent had levels below10 ng/mL. Although levels above 30 ng/mL are considered optimal for bone metabolism, only 10 percent of the study sample had levels in this range" - See vitamin D at Amazon.com.
  • Vitamin D and cardiovascular disease risk - Curr Opin Clin Nutr Metab Care. 2008 Jan;11(1):7-12 - "vitamin D deficiency may be a contributor to the development of cardiovascular disease potentially through associations with diabetes or hypertension"
  • Dietary fiber intake and retinal vascular caliber in the Atherosclerosis Risk in Communities Study - Am J Clin Nutr. 2007 Dec;86(6):1626-1632 - "Dietary fiber was related to wider retinal arteriolar caliber and narrower venular caliber, which are associated with a lower risk of cardiovascular disease. These data add to the growing evidence of the benefits of fiber intake on various aspects of cardiovascular pathogenesis"
  • Prevention of hypertension, cardiovascular damage and endothelial dysfunction with green tea extracts - Am J Hypertens. 2007 Dec;20(12):1321-8 - "green tea extract (GTE) ... The GTE prevented hypertension and target organ damage induced by a high Ang II dose, likely by prevention or scavenging of superoxide anion generation" - See green tea extract at Amazon.com.
  • Modest Gain In Visceral Fat Causes Dysfunction Of Blood Vessel Lining In Lean, Healthy Humans - Science Daily, 11/5/07 - "There are three parts to the take-home message here: One is that in healthy people, modest weight gain results in impaired endothelial function -- even in the absence of changes in blood pressure. The second is the encouraging news: endothelial function recovers after weight loss. The third point is that it is visceral fat -- the abdominal fat that surrounds internal organs -- rather than fat deposited as subcutaneous fat, just under the skin, that predicts endothelial dysfunction"
  • Resveratrol inhibits TNF-alpha-induced changes of adipokines in 3T3-L1 adipocytes  - Biochem Biophys Res Commun. 2007 Oct 26 - "resveratrol may improve obesity-induced cardiovascular disease, particularly atherosclerosis, by attenuating the TNF-alpha-induced changes of adipokines" - See my favorite resveratrol products at Amazon.com.
  • Whole Grains Cut Heart Failure Risk - WebMD, 10/22/07 - "the risk of heart failure among those who ate breakfast cereal at least seven times a week was 29% lower than that the risk among those who never ate cereal, after adjusting for other heart disease risk factors ... When researchers further analyzed the results they found this healthy effect was associated with whole-grain cereals only, not with refined breakfast cereals"
  • Why Garlic Is Good for You - WebMD, 10/15/07 - "red blood cells process compounds from digested garlic and turn them into the cell messenger hydrogen sulfide (H2S), which relaxes blood vessels and increases blood flow. Therefore, eating garlic may increase our natural supply of this vital chemical and play a role in reducing the risk of heart disease" - See garlic supplements at Amazon.com.
  • Beyond lipids: the role of omega-3 Fatty acids from fish oil in the prevention of coronary heart disease - Curr Atheroscler Rep. 2007 Aug;9(2):145-53 - "Results of the recent JELIS trial in a Japanese population already consuming a high intake of omega-3 fatty acids showed a 19% risk reduction in major coronary events" - See Mega Twin EPA at Amazon.com.
  • Statins' Effect on Endothelial Function Enhanced by L-arginine in Some Patients - Doctor's Guide, 6/11/07 - "endothelium-dependent dilation (EDD) ... simvastatin had no appreciable effect on EDD (6.2+/-1.2% vs. 6.1+/-0.9%) in subjects with elevated ADMA. However, the addition of L-arginine to simvastatin significantly improved EDD (9.8+/-1.5% vs. 5.3+/-0.8%; P <.01). There were also significant improvements in EDD in response to L-arginine alone" - See L-arginine products at Amazon.com.
  • Pine extract prevents heart failure damage in mice - Reuters, 5/22/07 - "The effectiveness of Pycnogenol supplementation is a great option for many people who want an alternative to prescription medications such as beta-blockers or ACE inhibitors" - See Pine Bark/Pycnogenol products at iHerb.
  • Health Benefits Of Whole Grains Confirmed - Science Daily, 5/9/07 - "Consuming an average of 2.5 servings of whole grains each day is associated with a 21 percent lower risk of cardiovascular disease compared to consuming only 0.2 servings"
  • Cut Heart Risk by Eating Less Salt - WebMD, 4/19/07 - "people who reduced their dietary sodium while participating in the studies saw 25% reductions in heart disease and stroke risk 10 to 15 years later, compared with people who ate their usual diets"
  • Fish Oil: Getting to the Heart of It - Medscape, 4/12/07 - "A food-based approach to increasing intake of omega-3 fatty acids is preferable. However, for those with known CHD, the increased dose required to lower triglycerides could be as much as 4 g/day. Consuming fish 2.5 to 3 times a week would provide a combined intake of about 500 mg EPA and DHA/day.[21] It is unrealistic to think that these high daily doses could be achieved through diet alone, resulting in a requirement for supplementation" - See Mega Twin EPA at Amazon.com.
  • The impact of olive oil consumption pattern on the risk of acute coronary syndromes: the cardio2000 case-control study - Clin Cardiol. 2007 Mar;30(3):125-9 - "Exclusive use of olive oil during food preparation seems to offer significant protection against CHD, irrespective of various clinical, lifestyle and other characteristics of the participants"
  • Omega-3 Fatty Acid May Protect Heart - WebMD, 3/29/07 - "2.8% of those taking EPA along with statins experienced a major coronary event, compared with 3.5% of those only taking statins ... That's a 19% difference" - See Mega Twin EPA at Amazon.com.
  • Use Folic Acid To Cut Heart Disease, Say Experts - Science Daily, 11/28/06 - "The scientific evidence is strong enough to justify using folic acid as a cheap and simple way of reducing heart disease and strokes"
  • Folic Acid Modestly Protects Against Cardiovascular Events - Medscape, 11/27/06 - "the combined evidence from cohort, genetic, and randomized controlled studies is indeed strong enough to support a modest protective effect of this nutrient"
  • Flavonoid-Rich Grapeseed Extracts: for Cardiovascular Patients - Medscape, 11/9/06 - "The antioxidant and vascular protective aspects of flavonoid-rich products such as GSE, when combined with the potential hypolipidaemic and anti-platelet effects make a strong case for its potential in preventing and treating diseases associated with endothelial injury, oxidative damage and inflammation; chief among which are type 2 DM and atherosclerotic vascular disease ... the use of GSE in such patients may demonstrate concomitant improvements in insulin resistance, endothelial function, inflammation in high-risk patient groups and ultimately cardiovascular outcome" - See grape seed extract at Amazon.com.
  • Moderate Drinking May Help Male Heart - WebMD, 10/23/06 - "men who reported drinking half a drink to two drinks daily were least likely to have had heart attacks"
  • Fish Oils Produce Anti-inflammatory Effects and Improve Body Weight in Severe Heart Failure - J Heart Lung Transplant. 2006 Jul;25(7):834-8. Epub 2006 May 24 - "Fish oils decrease TNF-alpha production in heart failure and improve body weight. Fish oil therapy may represent a novel therapeutic approach in late-stage heart failure characterized by cardiac cachexia"
  • 5 Superfoods for Your Heart - WebMD, 5/31/06 - "Blueberries ... Salmon ... Soy Protein ... Oatmeal ... Spinach"
  • Coffee May Help Postmenopausal Heart - WebMD, 5/30/06 - "Women who reported drinking one to three daily cups of coffee at the study's start were 24% less likely to die of heart disease during the study"
  • Hearty Drinkers Have Healthy Hearts - WebMD, 5/25/06 - "Over nearly six years, men who drank every day cut their risk of heart disease by 41%. Women who drank at least once a week cut their risk of heart disease by 36% or more ... Women who drank the most -- 14 or more drinks per week -- generally had the lowest risk of heart disease: as much as a 73% decrease in risk"
  • Intake of Fish and n3 Fatty Acids and Risk of Coronary Heart Disease Among Japanese. The Japan Public Health Center-Based (JPHC) Study Cohort I - Circulation. 2006 Jan 9 - "Compared with a modest fish intake of once a week or approximately 20 g/d, a higher intake was associated with substantially reduced risk of coronary heart disease, primarily nonfatal cardiac events, among middle-aged persons" - See Mega Twin EPA at Amazon.com.
  • Thiamin Deficiency Common in Hospitalized Heart Failure Patients - Doctor's Guide, 1/13/06 - "Among patients hospitalized with heart failure, about one in three has deficient levels of thiamin ... a relatively small dose of thiamin from a multi-vitamin was protective against developing thiamin deficiency"
  • Usefulness of omega-3 Fatty acids and the prevention of coronary heart disease - Am J Cardiol. 2005 Dec 1;96(11):1521-9 - "the evidence suggests a role for fish oil (eicosapentaenoic acid, docosahexaenoic acid) or fish in secondary prevention because recent clinical trial data have demonstrated a significant reduction in total mortality, coronary heart disease death, and sudden death. The data on ALA have been limited by studies of smaller sample size and limited quality"
  • Green tea 'may protect the heart' - BBC News, 2/28/05 - "a major chemical component of green tea known as epigallocatechin-3-gallate (EGCG) can reduce cell death after a heart attack or stroke ... EGCG also appears to speed up the recovery of heart cells" - See green tea extract at Amazon.com.
  • Columbia Study Suggests Brushing Your Teeth May Reduce Risk Of Stroke And Heart Attack - Science Daily, 2/17/05 - "people with gum disease are more likely to suffer from atherosclerosis – a narrowing of blood vessels that can lead to stroke or heart attack ... one possible explanation for the link is that the bacteria that cause the gum disease may migrate throughout the body via the bloodstream and stimulate the immune system, causing inflammation that results in the clogging of arteries"
  • Whole Grains Help Your Heart - WebMD, 12/29/04 - "Eating just 25 grams of whole grains a day reduces the risk of heart disease by about 15%"
  • Scientists Discover Recipe For Life: Eating The 'Polymeal' Cuts Heart Disease By 76% - Science Daily, 12/17/04 [Abstract] - "Results of dining on the Polymeal were most dramatic for men, who were projected to live on average 6.6 years longer in total than those not eating the meal ... The Polymeal includes wine, fish, dark chocolate, fruits and vegetables, almonds and garlic, eaten on a daily basis (but four times a week for fish). Scientists reviewed the medical literature on how much each ingredient cuts heart disease, blood pressure or cholesterol levels by varying amounts, (150ml wine daily for instance reduces heart disease by 32%) and worked out the combined effect of the ingredients"
  • Nutrition Advice You Can Take to Heart - WebMD, 9/22/04 - "we could cut our rate of heart disease by one-half if we took more magnesium ... the way to combat high homocysteine is to take folic acid ... Niacin (also known as vitamin B-3) helps increase HDL ... Potassium helps regulate blood pressure levels ... A lot of people think of calcium as for the bones, but it's also good for the heart"
  • Exercise Stalls Effects of Aging on the Heart - WebMD, 9/16/04
  • Prolonged, Sustained Exercise Prevents Precursor To Heart Failure - Science Daily, 9/14/04 - "We found that the older, sedentary individuals' hearts were 50 percent stiffer than the Masters athletes, which we expected ... what we didn't expect was that the hearts of these senior athletes were indistinguishable from those of the healthy younger participants"
  • Omega-3 Fatty Acids Get New Health Claim - WebMD, 9/8/04 - "The FDA now says it will allow foods and supplements containing eiscosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) omega-3 fatty acids to carry a qualified health claim that says eating the product may reduce the risk of heart disease"
  • Low Chromium Linked to Heart Disease Risk in Patients With Diabetes - Medscape, 9/3/04 - "Our results suggest that diabetic men with CVD have lower toenail chromium than healthy control subjects"
  • Fish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease - Am J Clin Nutr. 2004 Sep;80(3):626-32 - "Consumption of fish is associated with a significantly reduced progression of coronary artery atherosclerosis in women with coronary artery disease" - See Mega Twin EPA at Amazon.com.
  • Tomato Juice for Cardiovascular Health? - WebMD, 8/17/04 - "Half the group drank 1 cup of clarified tomato juice daily for three weeks; the rest took a tomato-flavored placebo ... the juice drinkers had a reduction in platelet clumping or aggregation, one of several steps thought to be important in the formation of blood clots that may lead to heart attacks and strokes"
  • Aspirin Lowers Risk of a First Heart Attack by One-Third - Doctor's Guide, 9/23/03 - "Aspirin reduces the risk of a first heart attack by 32 percent, according to a report published in the current issue of Archives of Internal Medicine" - See aspirin at Amazon.com.
  • DHEA May Fight Heart Disease, But How? - WebMD, 7/23/03 - "taking small doses of DHEA improved insulin sensitivity and endothelial function -- two factors that contribute to the development of heart disease -- in 24 middle-aged men with high cholesterol" - See DHEA at Amazon.com.
  • Researchers Devise a Single-Pill Drug Strategy for Targeting Cardiovascular Risk Factors - Doctor's Guide, 7/10/03 - "the Polypill would reduce IHD events by 88%"
  • Manage Heart Failure With Lifestyle - WebMD, 5/6/03
  • Improve Your Sex Life And Protect Against Heart Attack - Life Extension Magazine, 5/03 - "low testosterone levels were associated with several risk factors for heart attack such as high insulin levels, abnormal glucose metabolism, low levels of HDL cholesterol and high blood pressure. Moreover, he further proposed that the converse was also true: testosterone protects against heart disease in men"
  • Walking Won't Prevent Heart Disease - WebMD, 4/15/03 - "only more strenuous exercise and physical activity, such as jogging, swimming, and climbing stairs, on a regular basis can significantly reduce the risk of early death due to heart disease"
  • Whole-Grain Cereal Lengthens Lives - thesandiegochannel.com, 3/28/03 - "men who ate one serving of whole-grain, high-fiber cereal every day were nearly 30 percent less likely to die from heart disease or other diet-related diseases ... the more whole-grain cereal the men ate, the lower their risk of death from heart disease ... Whole-grain cereals contain the kind of fiber that helps lower cholesterol and blood pressure and improves how the body processes insulin and glucose. Whole grains also have more vitamins, minerals and antioxidants than refined cereal ... To make sure a cereal contains whole grains, check the ingredient list. Whole grain or bran should be listed as the first ingredient ... To be a whole-grain cereal, it must contain at least 2 grams of fiber per serving, preferably more"
  • Sleep, Less and More, Linked to Heart Disease - WebMD, 1/24/03
  • More Booze, Fewer Heart Attacks? - WebMD, 1/8/02 - "men who drank alcohol three to four times or more per week were about 30-40% less likely to have a heart attack during the 12-year period, compared with men who drank less than once a week ... the type of alcohol beverage didn't matter -- beer, wine, or liquor -- they all provided some protection against heart disease, although the strongest association for the reduced risk was with beer and liquor"
  • Three Diet Strategies Help Prevent Coronary Heart Disease - Doctor's Guide, 11/27/02 - "Evidence is now clear that diets including non-hydrogenated unsaturated fats as the predominant form of dietary fat, whole grains as the main form of carbohydrate, an abundance of fruit and vegetables and adequate omega-3 fatty acids can offer significant protection against CHD"
  • Folic Acid for Your Heart - WebMD, 11/22/02 - "By increasing folic acid intake and thus decreasing homocysteine, the researchers say the risk of heart disease would drop by 16%, blood clots in the legs by 25%, and stroke by 24%" - See folic acid at Amazon.com.
  • Argument Strengthens For Folic Acid To Reduce Homocysteine Level - Doctor's Guide, 11/26/02 - "A decrease in serum homocysteine of 3 micromol/l, which can be achieved by a daily intake of about 0.8 mg folic acid, should reduce the risk of ischaemic heart disease by 16 percent, deep vein thrombosis by 25 percent, and stroke by 24 percent" - See folic acid at Amazon.com.
  • Fatty acids from fish can ward off heart attacks - Intelihealth, 11/19/02 - "Studies now suggest that components of fish oil, called omega-3 fatty acids, can save the lives of people with heart disease ... The heart association also cited recent research indicating that even people with healthy hearts can benefit from a diet rich in such fish as salmon, bluefish, Arctic char, mackerel and swordfish ... fish can reduce a man's risk of dying from a heart attack by 80% ... omega-3 fatty acids can cut a woman's risk of death by heart attack by 33% ... Fatty fish can contain significant levels of mercury" - Omega-3 is the sum of the EPA and DHA not the total oil.  See Mega Twin EPA at iHerb.
  • Daily Exercise Training As Effective As Stent Angioplasty In Stable Coronary Artery Disease - Doctor's Guide, 11/19/02
  • Coronary Artery Disease Risk Among Asians Cut By Adopting Indo-Mediterranean Diet - Doctor's Guide, 11/7/02
  • Dose-Response Relationship Between Exercise, Heart Disease In Men - Doctor's Guide, 10/23/02 - "There is a significant inverse, dose-response relationship between total physical activity and risk of myocardial infarction (MI), and coronary heart disease (CHD) in men"
  • Weight Training May Help Heart - Intelihealth, 10/23/02
  • Acetylcysteine Can Reduce Cardiovascular Events in Patients with Endstage Renal Disease - Doctor's Guide, 10/1/02 - "therapy with acetylcysteine appears to significantly reduce cardiovascular events among haemodialysis patients" - See iHerb acetyl-l-cysteine products.
  • More Good News on Tea - WebMD, 9/27/02 - "The latest studies suggest tea might lower cholesterol, improve heart health, prevent rectal cancer in women, and reduce cell damage in smokers" - See green tea extract at Amazon.com.
  • Alcohol Can Help Women's Hearts Too - WebMD, 9/16/02 - "10 men aged 45-64 and nine women aged 49-62 drank either regular beer or non-alcoholic beer for three weeks ... After 10 days of drinking alcohol, HDL cholesterol levels rose by an average of nearly 7% for both men and women ... Previous research suggests that a 1% increase in HDL cholesterol is linked to a 2% reduction in the risk of heart disease"
  • Eat Nuts For A Healthy Heart - New Hope Natural Media, 8/1/02
  • Novel Method of Enhancing Anti-Fat Effects of CLA - Life Extension Magazine, 8/02 - "CLA is not just for fat-loss. Studies show it may help protect against many diseases including atherosclerosis and cancer" - See conjugated linoleic acid at Amazon.com.
  • Negative Results in Antioxidant-Heart Study Challenged: A Healthnotes Newswire Opinion - New Hope Natural Media, 7/11/02 - "Nutrients work in the body as a team, and all of them must be present in adequate amounts in order to promote good health. If magnesium, for example, were the weakest link in the nutritional chain, one would not expect antioxidants to do much good until the magnesium deficiency was corrected ... Rather than testing only one or a few nutrients at a time, researchers should use a supplement that contains all of the nutrients known to promote heart health" - Some of my concerns:  All the vitamin E studies I've read have only used the alpha tocopherol and taking only the alpha has been shown to significantly lower the gamma tocopherol.  I also feel that the studies using only beta carotene are pointless.  Beta carotene is just one of over 600 carotenoids and many researchers believe that taking mega doses of just one carotenoid can cause of deficiency of the others.
  • Vitamin C May Prevent Platelet Aggregation - Doctor's Guide, 5/28/02 - "Vitamin C may inhibit collagen-induced platelet aggregation. This may add to the protection that vitamin C is already known to give against coronary heart disease ... In smokers who received vitamin C, there were significant decreases in platelet aggregation after six hours with both collagen concentrations compared to placebo. In non-smokers, there were significant decreases of platelet aggregation after three and six hours for both collagen concentrations"
  • Vitamin C Beneficial In Heart Disease - Doctor's Guide, 5/27/02 - "These two groups were split into subgroups: those who received 2 g of vitamin C and those who did not after eating high-fat meal ... Although the postprandial flow-mediated dilatation was significantly aggravated in people not taking vitamin C (both with and without heart disease), this parameter in patients and subjects taking vitamin C showed no significant change"
  • Physical Training Benefits Heart-failure Patients - Doctor's Guide, 5/15/02
  • Take Aspirin at Night for Heart Benefits - WebMD, 5/15/02 - "Aspirin didn't affect blood pressure if given in the morning. But when given at night, it had a significant effect: a 7.0 mmHg decrease in systolic blood pressure (the top number in a blood-pressure reading) and a 4.8 mmHg decrease in diastolic blood pressure (the bottom number)."
  • Tea Prolongs Survival After Heart Attack - WebMD, 5/6/02 - "Researchers say the findings add to a growing notion that the antioxidant-rich flavonoids found in black and green teas prevent heart disease. But this is the first study to suggest that drinking tea can actually protect the heart after damage has already occurred"
  • Folate Fights Stroke and Heart Disease - WebMD, 5/2/02 - "people who consumed at least 300 mcg of folate every day had a 20% lower risk of stroke and a 13% lower risk of cardiovascular disease than those consuming less than 136 mcg of folate per day ... Folate is also thought to offset risk of cardiovascular disease, by reducing levels of homocysteine in the blood. Homocysteine is linked with higher risk of atherosclerosis because it damages arteries, but vitamins B-6 and B-12, as well as folic acid, have been found to prevent that damage from occurring"
  • What's Wrong With Vitamin E? - Life Extension Magazine, 5/02 - "Tocotrienols and cardiovascular disease ..."
  • Tea Drinking Good for the Heart - WebMD, 4/25/02
  • Four New Studies Strongly Suggest That Components From Three Types [elderberry, chokeberry and bilberry]  Of Red Berry Fruits Help Arteries - Intelihealth, 4/22/02
  • A Popular Japanese Plum [umeboshi], Now Available In The US, May Help Prevent The Onset Of Cardiac Disease - Intelihealth, 4/22/02
  • Regular Walking Aids Older Arteries - WebMD, 4/22/02 - "The 12-week study involved a group of 14 women, all about age 60, who didn't exercise but were otherwise healthy ... At the end of the study, they all had nearly 50% improvement in elasticity of arteries ... The exercise schedule: the women walked just five days a week for 40 to 45 minutes"
  • Fish Oil Supplements Protect Heart - WebMD, 4/8/02 - "A daily fish oil supplement may help heart attack survivors reduce their risk of sudden death by as much as 42% ... taking one gram daily of omega-3 fatty acids significantly reduced the risk of death in people who had heart attacks ... the researchers found these benefits were not related to common explanations such as lowering cholesterol levels or reducing blood clots ... fatty acids may play a part in regulating the electrical activity of heart muscle cells -- a process responsible for the heart rhythm"
  • Saunas Improve Heart Failure - WebMD, 3/15/02
  • Researchers Find Wine-Heart Link - Intelihealth, 12/20/01
  • Legumes Reduce Risk Of Heart Disease - Intelihealth, 11/29/01 - "participants who consumed legumes at least four times per week had a 22% lower risk of coronary heart disease and an 11% lower risk of cardiovascular disease compared to those who consumed legumes less than once a week"
  • Folate Cost-Effective For Prevention Of Coronary Artery Reblockage - Intelihealth, 11/29/01 - "The vitamin therapy included a combination of folic acid (also known as folate or vitamin B9), vitamin B12, and vitamin B6. Patients who received the vitamins had significantly lower levels of homocysteine, and lower rates of restenosis and cardiac complications"
  • Vitamin C Inhibits Cell Death In Congestive Heart Failure Patients - Intelihealth, 10/30/01
  • Dry Sauna Heat Helps the Heart - WebMD, 10/1/01 - "Two weeks of daily sauna treatment didn't change the blood vessel function of the normal men -- but it helped most of the at-risk men ... only two weeks of repeated once-a-day sauna treatment significantly improved [the blood vessel] function -- about 40% -- of patients with coronary risk factors"
  • After Heart Attack, Lifting Weights Lifts Mood - WebMD, 9/19/01 - "lifting a few light weights on a regular basis actually can lift a guy's spirits, plus it can reduce the risk of another bad heart episode"
  • Folic Acid/Vitamin B12 Show Potential as Heart Disease Treatments - Doctor's Guide, 8/22/01
  • High Fatty Acid Levels May Mean Sudden Death For Middle-Aged Men - Intelihealth, 8/14/01 - "The editorial suggests that increasing omega-3 fatty acids in the diet, which come from fatty fish or canola oil, and decreasing the intake of omega-6 fatty acids, found in plant seed oils (corn, safflower, sunflower), is a way to reduce the risk of sudden death"
  • Free Fatty Acids May Be Linked to Sudden Cardiac Death in Healthy Men - WebMD, 8/14/01 - "Very high levels of free fatty acids were associated with "2.5 to three times the risk for sudden cardiac death" ... Several factors, including cigarette smoking, fasting, hyperthyroidism, or heart attack, can trigger the release of free fatty acids ... The real risk, says Leaf, who is professor of clinical medicine at Harvard Medical School, comes from omega-6 fatty acids, which are found in foods fried in corn, safflower, or sunflower oils ... By contrast omega-3 fatty acids, which are found in fatty fish and canola oil are actually heart healthy"
  • Newly Hip Nutrient May Stave Off Heart Disease - WebMD, 6/21/01 - "the team gave lutein supplements to two types of heart-disease prone mice. These treated mice had significantly less atherosclerosis than did similar mice that hadn't received the supplemental lutein"
  • Arterial Disease Depletes Body of Vitamin C - WebMD, 4/9/01 - "In atherosclerosis, arteries and other blood vessels are lined with fat deposits and buildup of cellular materials, including inflammatory cells, which release unstable molecules called free radicals. The free radicals do additional damage to the delicate vessels, says Langlois. Antioxidants such as vitamin C seek out and destroy free radicals, but in the process the antioxidants are themselves destroyed ... PAD appears to kick the body's inflammatory process into high gear, which then releases a free radical bombardment, that can "deplete the supply of vitamin C""
  • Fatty Fish -- Not Fried -- Reduces Heart Attack Deaths in Older Adults - WebMD, 2/28/01 - "Those who ate at least one serving of fatty fish every week were 35% less likely to die of a heart attack."
  • Folic Acid and Vitamin B-12 May Help Prevent Heart Disease - WebMD, 12/11/00
  • Tea May Be Heart-Healthy - Intelihealth, 11/14/00
  • Got Magnesium? Those With Heart Disease Should - WebMD, 11/9/00 - "Similar magnesium supplements are available over-the-counter in the U.S., but they might not provide similar benefits. "The product we used is from Germany, where supplements of this kind are regulated and quality is monitored," Merz says. "Because that is not the case in the U.S., it is impossible to know what you are getting in a supplement, or even whether it contains any magnesium at all.""
  • Orange Juice Improves Hypercholesterolemic Blood Lipids - Doctor's Guide, 11/9/00
  • Study Says Vitamin C Helps Prevent Strokes - Intelihealth, 10/27/00
  • Vitamin E Reduces Levels Of Protein That Predicts Heart Disease - Doctor's Guide, 10/24/00
  • Folic Acid and the Heart Turning Into Fast Friends - WebMD, 8/31/00
  • Hawthorn: Old Reliable for the Heart - Nutrition Science News, 8/00
  • For Reducing Heart Disease Risk, Fish Oil Isn't Snake Oil - WebMD, 8/8/00
  • 3 B's Block Cardiovascular Disease - Nutrition Science News, 7/00
  • How CoQ10 Protects Your Cardiovascular System - Life Extension Magazine, 4/00
  • Hearts & Bones: Calcium's Many Applications - Nutrition Science News, 2/00
  • Chocolate: A heart-healthy confection? - CNN, 2/2/00
  • Ginkgo biloba, a potential to treat heart disease - CNN, 8/6/99
  • Fiber may reduce women's risk of heart disease - CNN, 6/1/99
  • Low-fat diet, not wine, fights heart disease in France - CNN, 5/28/99
  • Sidestep Heart Disease - Nutrition Science News, 3/99
  • Prolonged treatment with slow release nicotinic acid in patients with type II hyperlipidemia - Pol Arch Med Wewn. 1997 Nov;98(11):391-9
  • The effect of long-term Enduracin monotherapy on the clinical and biochemical status of patients with ischemic heart disease - Ter Arkh. 1997;69(9):41-5
  • A comparison of the efficacy and toxic effects of sustained- vs immediate-release niacin in hypercholesterolemic patients - JAMA. 1994 Mar 2;271(9):672-7

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