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Home > Anti-aging Research > Hesperidin


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  • Citrus extracts show energy burning potential, without side effects: Study - Nutra USA, 5/17/11 - "consumption of 100 mg hesperidin, 50 mg p-synephrine (from bitter orange), and 600 mg naringin increased the resting metabolic rate by about 18 percent ... If one assumes that the product was taken twice a day for one year, the theoretical increase in calorie consumption would amount to over 31 pounds ... None of the treatment groups exhibited changes in heart rate or blood pressure relative to the control group, nor there were no differences in self-reported ratings of 10 symptoms between the treatment groups and the control group ... the thermogenic effect of p-synephrine may be increased by naringin and hesperidin via an enhancement in the production of the expression of adiponectin, a hormone released from fat cells, which plays an important role in the regulation of insulin sensitivity and energy" - [Abstract]
  • Orange juice flavanone may benefit heart health: Study - Nutra USA, 12/17/10 - "The researchers reported that blood pressure was significantly lowered after 4 weeks consumption of orange juice or a hesperidin rich drink when compared to a placebo drink" - [Abstract]
  • Daily Glass of Orange Juice Is Heart Smart - WebMD, 7/20/09 - "An antioxidant in orange juice called hesperidin improves blood vessel function and helps lower a person’s risk of heart disease ... An antioxidant in orange juice called hesperidin improves blood vessel function and helps lower a person’s risk of heart disease"
  • Citrus flavanones show neuroprotection potential - Nutra USA, 1/21/08 - "These results first demonstrate that the citrus flavanones hesperidin, hesperetin, and neohesperidin, even at physiological concentrations, have neuroprotective effects against H2O2-induced cytotoxicity in PC12 cells ... These dietary antioxidants are potential candidates for use in the intervention for neurodegenerative diseases ... One such disease that is mentioned Alzheimer's disease" - [Abstract]
  • Citrus extracts get cholesterol-lowering boost - Nutra USA, 3/26/07
  • Men's Fitness: Boost your good cholesterol sky-high: want to live longer? Try raising this cholesterol with our 10 strategies - findarticles.com, 2/02 - "In a Canadian study, drinking a few glasses of orange juice every day for four weeks increased participants' HDL by 21 percent, possibly due to a flavonoid called hesperidin that appears extremely HDL-friendly"
  • High Levels of HDL Cholesterol Can Save Your Life - ABC News, 11/3/00 - "So how much HDL is enough? Current guidelines say 35 milligrams per deciliter of blood (mg/dl) is normal, but most cardiologists would prefer you to have an HDL count that’s twice that. “The higher the better,” says Gaziano. “Once you get over 60 mg/dl, it’s a strong positive factor in avoiding heart disease.” ... this will increase your HDL by 21 percent (or 10 to 20 points) within 4 weeks. “We’re not sure, but this effect may be due to a flavonoid in orange juice called hesperidin"
  • Herbal Treatment for Varicose Veins - Nutrition Science News, 7/00


  • Benefits of Hesperidin for Cutaneous Functions - Evid Based Complement Alternat Med. 2019 Apr 2;2019:2676307 - "Hesperidin is a bioflavonoid, with high concentration in citrus fruits. In addition to its well-known benefits for cardiovascular function, type II diabetes, and anti-inflammation, recent studies have demonstrated multiple benefits of hesperidin for cutaneous functions, including wound healing, UV protection, anti-inflammation, antimicrobial, antiskin cancer, and skin lightening. In addition, hesperidin enhances epidermal permeability barrier homeostasis in both normal young and aged skin. The mechanisms by which hesperidin benefits cutaneous functions are attributable to its antioxidant properties, inhibition of MAPK-dependent signaling pathways, and stimulation of epidermal proliferation, differentiation, and lipid production. Because of its low cost, wide availability, and superior safety, hesperidin could prove useful for the management of a variety of cutaneous conditions" - See hesperidin at Amazon.com.
  • Hesperidin Protects Against Intestinal Inflammation By Restoring Intestinal Barrier Function and Up Regulating Treg Cells - Mol Nutr Food Res. 2019 Feb 28 - "Hesperidin supplementation ameliorated DSS-induced colitis. Specifically, hesperidin ameliorates intestine inflammation through decreasing MDA activity and enhancing SOD and GSH activities. Hesperidin also obviously upregulation Nrf2 antioxidant pathway and increased the protein expression of HO-1 and NQO1. Additionally, hesperidin significantly reduced the levels of inflammatory factors and increased the levels of anti-inflammatory factors in the colon tissues. Further analysis showed that hesperidin could improve the expression of tight junction proteins and intestinal permeability, as well as increased the Treg population. In Caco-2 cells, we showed that hesperidin prevented TNF-α/IFN-γ-induced reduced in TEER and morphological disruption. Moreover, hesperidin also was shows decreased the epithelial permeability and suppress proinflammatory responses"
  • The citrus flavanone hesperetin preferentially inhibits slow-inactivating currents of an LQT3 syndrome Na+ channel mutation - Br J Pharmacol. 2019 Jan 16 - "lethal ventricular arrhythmias in the Long QT syndrome subtype 3 (LQT3) ... HSP preferentially inhibits the slow inactivation phase of INa , more markedly in the mutant R1623Q. HSP could be used as a template to develop drugs against lethal cardiac arrhythmias in LQT3"
  • Hesperidin Prevents Nitric Oxide Deficiency-Induced Cardiovascular Remodeling in Rats via Suppressing TGF-β1 and MMPs Protein Expression - Nutrients. 2018 Oct 19;10(10) - "n-nitro l-arginine methyl ester (l-NAME) ... Male Sprague-Dawley rats were treated with l-NAME (40 mg/kg), l-NAME plus hesperidin (15 mg/kg), hesperidin (30 mg/kg), or captopril (2.5 mg/kg) for five weeks (n = 8/group). Hesperidin or captopril significantly prevented the development of hypertension in l-NAME rats. l-NAME-induced cardiac remodeling, i.e., increases in wall thickness, cross-sectional area (CSA), and fibrosis in the left ventricular and vascular remodeling, i.e., increases in wall thickness, CSA, vascular smooth muscle cells, and collagen deposition in the aorta were attenuated by hesperidin or captopril. These were associated with reduced oxidative stress markers, tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta 1 (TGF-β1), and enhancing plasma nitric oxide metabolite (NOx) in l-NAME treated groups. Furthermore, up-regulation of tumor necrosis factor receptor type 1 (TNF-R1) and TGF- β1 protein expression and the overexpression of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) was suppressed in l-NAME rats treated with hesperidin or captopril. These data suggested that hesperidin had cardioprotective effects in l-NAME hypertensive rats"
  • Long-term Treatment with Hesperidin Improves Endothelium-dependent Vasodilation in Femoral Artery of Spontaneously Hypertensive Rats: The Involvement of NO-synthase and Kv Channels - Phytother Res. 2016 Jul 1 - "Hesperidin is the most common flavonoid found in citrus fruits and is expected to exert vasodilation action relevant to its health benefits ... The results of our experiment indicate that hesperidin might improve the endothelium-dependent vasodilation during hypertension, possibly through the enhancement of Kv channels function" - See hesperidin at Amazon.com.
  • Hesperidin ameliorates cognitive dysfunction, oxidative stress and apoptosis against aluminium chloride induced rat model of Alzheimer's disease - Nutr Neurosci. 2016 Feb 15 - "In our lab, we have previously reported that hesperidin, a citrus bioflavonoid reversed memory loss caused by aluminium intoxication through attenuating acetylcholine esterase activity and the expression of Amyloid β biosynthesis related markers ... Results of the present study demonstrated that hesperidin could be a potential therapeutic agent in the treatment of oxidative stress and apoptosis associated neurodegenerative diseases including AD"
  • Effect of Hesperidin with and without a Calcium (Calcilock®) Supplement on Bone Health in Postmenopausal Women - J Clin Endocrinol Metab. 2016 Jan 11 - "Citrus fruits contain unique flavanones. One of the most abundant of the flavanones, hesperidin, has been shown to prevent bone loss in ovariectomized rats ... Calcium plus hesperidin, but not hesperidin alone, improved bone calcium retention by 5.5%"
  • Hesperidin Supplementation Modulates Inflammatory Responses Following Myocardial Infarction - J Am Coll Nutr. 2015 Mar 11:1-7 - "Hesperidin supplementation could compensate for decreased levels of adiponectin and HDL-C and increased levels of E-selectin in patients with myocardial infarction. These results support the concept that certain flavonoids in the diet can be associated with significant health benefits, including heart health"
  • Hesperidin ameliorates behavioural impairments and neuropathology of transgenic APP/PS1 mice - Behav Brain Res. 2014 Dec 12 - "Our findings suggest that hesperidin might be a potential candidate for the treatment of AD or even other neurodegenerative diseases"
  • Hesperidin protects testicular and spermatological damages induced by cisplatin in rats - Andrologia. 2014 Sep 13 - "this study clearly demonstrated that hesperidin has protective effects on cisplatin-induced reproductive system toxicity depending on its antioxidant properties. Thus, it is thought that hesperidin may be useful against cisplatin toxicity in patients with cancer in terms of reproductive system"
  • Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats - J Diabetes Complications. 2012 Jul 16 - "Diabetes was induced by feeding rats with an HFD for 2weeks followed by an intraperitoneal injection of STZ (35mg/kg body weight). An oral dose of 50mg/kg hesperidin or naringin was daily given for 4weeks after diabetes induction ... At the end of the experimental period, blood was obtained from jugular vein and livers were rapidly excised and homogenized for biochemical assays. In the diabetic control group, levels of glucose, glycosylated hemoglobin (HbA1c%), MDA, NO, TNF-α and IL-6 were significantly increased, while serum insulin, GSH, vitamin C, and vitamin E levels were decreased. Both hesperidin and naringin administration significantly reversed these alterations. Moreover, supplementation with either compound significantly ameliorated serum and liver MDA, NO and glutathione, and liver antioxidant enzymes"
  • Citrus Polyphenol Hesperidin Stimulates Production of Nitric Oxide in Endothelial Cells while Improving Endothelial Function and Reducing Inflammatory Markers in Patients with Metabolic Syndrome - J Clin Endocrinol Metab. 2011 Feb 23 - "Hesperidin, a citrus flavonoid, and its metabolite hesperetin may have vascular actions relevant to their health benefits ... Treatment of BAEC with hesperetin acutely stimulated phosphorylation of Src, Akt, AMP kinase, and endothelial NO synthase to produce NO; this required generation of H(2)O(2). Increased adhesion of monocytes to BAEC and expression of vascular cell adhesion molecule-1 in response to TNF-α treatment was reduced by pretreatment with hesperetin. In the clinical study, when compared with placebo, hesperidin treatment increased flow-mediated dilation (10.26 +/- 1.19 vs. 7.78 +/- 0.76%; P = 0.02) and reduced concentrations of circulating inflammatory biomarkers (high-sensitivity C-reactive protein, serum amyloid A protein, soluble E-selectin). Conclusions: Novel mechanisms for hesperetin action in endothelial cells inform effects of oral hesperidin treatment to improve endothelial dysfunction and reduce circulating markers of inflammation in our exploratory clinical trial. Hesperetin has vasculoprotective actions that may explain beneficial cardiovascular effects of citrus consumption"
  • Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers - Am J Clin Nutr. 2010 Nov 10 - "Throughout the three 4-wk periods, volunteers consumed daily 500 mL orange juice, 500 mL control drink plus hesperidin (CDH), or 500 mL control drink plus placebo (CDP) ... Diastolic blood pressure (DBP) was significantly lower after 4 wk consumption of orange juice or CDH than after consumption of CDP (P = 0.02), whereas microvascular endothelium-related reactivity was not significantly affected when measured after an overnight fast. However, both orange juice and CDH ingestion significantly improved postprandial microvascular endothelial reactivity compared with CDP (P < 0.05) when measured at the peak of plasma hesperetin concentration"
  • Neuroprotective Effects of the Citrus Flavanones against H2O2-Induced Cytotoxicity in PC12 Cells - J Agric Food Chem. 2008 Jan 12 - "the citrus flavanones hesperidin, hesperetin, and neohesperidin, even at physiological concentrations, have neuroprotective effects against H 2O 2-induced cytotoxicity in PC12 cells. These dietary antioxidants are potential candidates for use in the intervention for neurodegenerative diseases" - See hesperidin at Amazon.com.
  • Hesperidin, a Citrus Flavonoid, Inhibits Bone Loss and Decreases Serum and Hepatic Lipids in Ovariectomized Mice - J. Nutr. 133:1892-1897, June 2003 - "These results suggest a possible role for citrus flavonoids in the prevention of lifestyle-related diseases because of their beneficial effects on bone and lipids"
  • Biological effects of hesperidin, a Citrus flavonoid. (note II): hypolipidemic activity on experimental hypercholesterolemia in rat - Farmaco. 1995 Sep;50(9):595-9 - "Hesperidin, the most important flavanone of Citrus sp., significantly increases HDL"