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Home > Anti-aging Research > Triglycerides

Triglycerides

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Note:  See my recommendation, Mega Twin EPA at iHerb or Vitacosticon or Jarrow Max DHA at iHerb.  Also my page on Essential Fatty Acids.

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  • Triglycerides - Life Extension Magazine
  • High Triglyceridesicon - Vitacost Health Library
  • Triglycerides Too High? - Dr. Weil, 5/30/07
  • Omega-3 fatty acid concentrates in the treatment of moderate hypertriglyceridemia - Expert Opin Pharmacother. 2008 May;9(7):1237-48 - "Prescription omega-3 fatty acid concentrates (P-OM3) are indicated for use in people with very high triglycerides ... P-OM3 are effective in reducing triglycerides by approximately 30% in this population" - See Mega Twin EPA at iHerb.
  • Omega-3 fatty acid containing diets decrease plasma triglyceride concentrations in mice by reducing endogenous triglyceride synthesis and enhancing the blood clearance of triglyceride-rich particles - Clin Nutr. 2008 Mar 22 - "Levels of hepatic TG and apoB synthesis were 30-50% and 42% lower in mice fed with the fish oil diet compared to the other three diets. In addition, compared to soy oil diet, fish oil feeding significantly increased blood clearance of chylomicron-like lipid emulsions by 21-26%" - See Mega Twin EPA at iHerb.
  • Omega-3 Fatty Acids May Be Useful for Cardioprotection - Medscape, 3/18/08 - "To date, the strongest evidence showing a CV benefit from omega-3 fatty acid intake derives from 3 large controlled trials in which a total of 32,000 participants were randomized to a control group or to receive omega-3 fatty acid supplements containing DHA and EPA. In these trials, the supplemented group had a 19% to 45% reduction in CV events vs the control group ... Patients with hypertriglyceridemia should consume 3 to 4 g/day of DHA and EPA, which can lower triglyceride levels by 20% to 50%" - See Mega Twin EPA at iHerb.
  • Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications - Expert Rev Cardiovasc Ther. 2008 Mar;6(3):391-409 - "Hypertriglyceridemia is a risk factor for atherosclerotic coronary heart disease. Very high triglyceride (TG) levels (>/=500 mg/dl [5.65 mmol/l]) increase the risk of pancreatitis. One therapeutic option to lower TG levels is omega-3 fatty acids, which are derived from the oil of fish and other seafood. The American Heart Association has acknowledged that fish oils may decrease dysrhythmias, decrease sudden death, decrease the rate of atherosclerosis and slightly lower blood pressure, and has recommended fish consumption or fish oil supplementation as a therapeutic strategy to reduce cardiovascular disease. A prescription omega-3-acid ethyl esters (P-OM3) preparation has been available in many European nations for at least a decade, and was approved by the US FDA in 2004 to reduce very high TG levels (>/=500 mg/dl [5.65 mmol/l]). Mechanistically, most evidence suggests that omega-3 fatty acids reduce the synthesis and secretion of very-low-density lipoprotein (VLDL) particles, and increase TG removal from VLDL and chylomicron particles through the upregulation of enzymes, such as lipoprotein lipase. Omega-3 fatty acids differ mechanistically from other lipid-altering drugs, which helps to explain why therapies such as P-OM3 have complementary mechanisms of action and, thus, complementary lipid benefits when administered with statins" - See Mega Twin EPA at iHerb.
  • Omega3 Fatty acids for cardioprotection - Mayo Clin Proc. 2008 Mar;83(3):324-32 - "The most compelling evidence for the cardiovascular benefit provided by omega-3 fatty acids comes from 3 large controlled trials of 32,000 participants randomized to receive omega-3 fatty acid supplements containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) or to act as controls. These trials showed reductions in cardiovascular events of 19% to 45%. These findings suggest that intake of omega-3 fatty acids, whether from dietary sources or fish oil supplements, should be increased, especially in those with or at risk for coronary artery disease. Patients should consume both DHA and EPA. The target DHA and EPA consumption levels are about 1 g/d for those with known coronary artery disease and at least 500 mg/d for those without disease. Patients with hypertriglyceridemia benefit from treatment with 3 to 4 g/d of DHA and EPA, a dosage that lowers triglyceride levels by 20% to 50%. Although 2 meals of oily fish per week can provide 400 to 500 mg/d of DHA and EPA, secondary prevention patients and those with hypertriglyceridemia must use fish oil supplements if they are to reach 1 g/d and 3 to 4 g/d of DHA and EPA, respectively" - See Mega Twin EPA at iHerb and Jarrow Max DHA at iHerb.  I take both because the percentage of omega-3 (EPA and DHA) is very low in other supplements.  I don't know what the rest of that oil is but your not saving anything by getting supplements with a low percentage.  Just do the math plus if the rest of the oil is an omega-6 you're not helping the omega-6/omega-3 ratio.
  • Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters - Biochem Biophys Res Commun. 2007 Dec 28 - "The concentrations of serum total cholesterol and triglyceride were significantly lower in the resveratrol-fed group than in the control group. The resveratrol contained diet significantly decreased Apo B, Lp(a), and cholesterol-ester-transport protein (CETP) concentrations, but increased Apo A-I levels and the Apo A-I/Apo B ratio. The contents of cholesterol and triglyceride in hepatic tissue were significantly lower in the resveratrol group than in the control group. Real-time PCR analysis revealed that HMGR mRNA expression was significantly lower in the resveratrol group than in the control group" - See Jarrow Resveratrol 100 at iHerb.
  • Combination Niacin-Laropiprant Plus Simvastatin Reduces Cholesterol by Almost 50% - Doctor's Guide, 11/6/07 - "When patients with dyslipidemia added simvastatin to their experimental combination of extended-release niacin and laropiprant -- a novel anti-flushing agent -- they reported reductions in low density lipoprotein cholesterol (LDL-C) of as much as 48% from baseline ... high density liopoprotein cholesterol (HDL-C) was increased by 28% and triglycerides decreased by 33%"
  • Role of prescription omega-3 Fatty acids in the treatment of hypertriglyceridemia - Pharmacotherapy. 2007 May;27(5):715-28 - "In patients with triglyceride levels above 500 mg/dl, approximately 4 g/day of EPA and DHA reduces triglyceride levels 45% and very low-density lipoprotein cholesterol levels by more than 50%" - See Mega Twin EPA at iHerb or Vitacosticon or Jarrow Max DHA at iHerb.
  • Effect of omega-3 Fatty Acid supplementation on the arachidonic Acid:eicosapentaenoic Acid ratio - Pharmacotherapy. 2007 May;27(5):633-8 - "Triglyceride levels were not reduced in patients with CAD but were significantly decreased in healthy subjects (by 20% decrease with omega-3 fatty acids 1.5 g/day and by 32% decrease with 3 g/day)"
  • Effect of combination lipid-modifying therapy on the triglyceride lowering effect of fish oil - Am J Med Sci. 2007 Mar;333(3):168-72 - "Fish oil effectively reduces plasma triglyceride levels when administered with concomitant lipid medications"
  • DHA alone can lower triglycerides, says study - Nutra USA, 2/7/07 - "Subjects were randomized to either 1000mg of DHA or 1252 mg of DHA + EPA for eight weeks ... triglycerides were lowered an average of 21.8 per cent in the DHA group and 18.3 per cent in the DHA + EPA group" - See Jarrow Max DHA at iHerb.
  • The triglyceride-lowering effects of a modest dose of docosahexaenoic acid alone versus in combination with low dose eicosapentaenoic acid in patients with coronary artery disease and elevated triglycerides - J Am Coll Nutr. 2006 Dec;25(6):480-5 - "randomized to either 1000 mg of DHA or 1252 mg of DHA + EPA for eight weeks ... Triglycerides decreased by an average of 21.8% in the DHA group (p < 0.001) and 18.3% in the DHA + EPA group (p < 0.001). The difference between groups was not significant. A greater proportion of subjects in the DHA group achieved triglyceride goal (less than 150 mg/dL) compared to the DHA + EPA group (24.6% versus 10.2%, p < 0.05)" - See Jarrow Max DHA at iHerb or Mega Twin EPA at iHerb.
  • Hypertriglyceridemia - Medscape, 6/1/06 - "Omega-3 fatty acids (4 g per day) will reduce triglyceride levels by 30% ... ER niacin has been shown to lower the triglyceride level by ~25% and raise the HDL level by almost 30%"
  • In search of those omega-3 fatty acids -  San Diego Union-Tribune, 3/7/06 - "Fish oils from supplements or dietary sources can reduce triglycerides by 20 percent to 50 percent ... Studies have used triglyceride-lowering doses of 1 to 4 grams (1,000 mg to 4,000 mg) daily"
  • Omega-3 Fatty Acids in the Management of Hypertriglyceridemia: New Findings and Formulations - Continuing Medical Education (CME):Princeton Media Associates, exp. 10/29/06 - "To lower TG levels, the dose of omega-3 therapy is ~4 g of EPA + DHA per day" - See Mega Twin EPA at iHerb or Vitacosticon.
  • Fish Oil Supplements Improve Lipid Risk Factors in Obese Children - Medscape, 11/14/05 - "given 3 g of a daily fish oil supplement ... After 12 weeks, the researchers found that triglyceride levels in the control group did not significantly differ from baseline. In contrast, triglyceride levels in children treated with fish oil significantly decreased. However, differences in other lipid measures were not statistically significant" - See Mega Twin EPA at iHerb or Vitacosticon.
  • Omega-3 Fatty Acids: Recommendations for Therapeutics and Prevention - Medscape, 10/19/05 - "Supplementation of 4 g EPA/DHA per day for 6 weeks resulted in a 20% TG decline in mildly hyperlipidemic middle-aged men"  - See Mega Twin EPA at iHerb or Vitacosticon.
  • Plasma Triglyceride and the Risk for Vascular Disease - Medscape, 9/19/05 - "omega-3 fatty acid therapy, particularly when administered in moderate doses[42] on a scale matching natural fish consumption, significantly reduces plasma triglyceride"
  • Women and Omega-3 Fatty Acids - Obstet Gynecol Surv. 2004 Oct;59(10):722-730 - "because elevated triglyceride levels are associated with cardiovascular disease, especially in women; and because omega-3 FA have powerful effects on triglycerides, women in particular gain from an increased intake of these fatty acids. This is especially important in women receiving hormone therapy, which can increase triglyceride levels." - See Mega Twin EPA at iHerb or Vitacosticon.
  • Increased n-6 polyunsaturated fatty acids do not attenuate the effects of long-chain n-3 polyunsaturated fatty acids on insulin sensitivity or triacylglycerol reduction in Indian Asians - Am J Clin Nutr. 2004 Jun;79(6):983-991 - "were supplemented with 4.0 g fish oil/d (2.5 g eicosapentaenoic acid + docosahexaenoic acid) ... After the 6-wk period of fish oil supplementation, fasting and postprandial plasma triacylglycerol concentrations decreased significantly" - See Mega Twin EPA at iHerb or Vitacosticon.
  • Soy protein reduces triglyceride levels and triglyceride fatty acid fractional synthesis rate in hypercholesterolemic subjects - Atherosclerosis. 2004 Apr;173(2):269-75 - "Soy protein reduced TG by 12.4% ( [Formula: see text] ) ... compared to animal protein"
  • Dietary linolenic acid is inversely associated with plasma triacylglycerol: the National Heart, Lung, and Blood Institute Family Heart Study - Am J of Clin Nutr, Vol. 78, No. 6, 1098-1102, 12/03 - "We used generalized linear models to estimate adjusted mean triacylglycerol concentrations according to categories of total dietary linolenic acid (alpha- and gamma-linolenic acid) intake ... Consumption of total linolenic acid is inversely related to plasma triacylglycerol concentrations in both white men and white women. This suggests a pathway by which dietary linolenic acid might reduce cardiovascular disease risk" - The way I understand it, by linolenic acid they are talking about alpha (omega-3) and gamma (GLA, an omega-6). - Ben
  • Eating Fish Lowers Heart Disease Risk in Women With Diabetes - WebMD, 3/31/03 - "It is believed that omega-3 fatty acids abundant in the fat of many fish reduces the risk of heart disease by lowering triglyceride levels, improving blood vessel function, and reducing blood-clot formation"
  • Lipid Benefits With Monounsaturated-Fatty-Acids Diet In Healthy People - Doctor's Guide, 3/14/03 - "A moderate supplementation of long-chain n-3 fatty acids in healthy individuals reduces both fasting and post-prandial triacylglycerol concentrations but increases LDL cholesterol, irrespective of the type of diet"
  • Differential effects of saturated and monounsaturated fats on postprandial lipemia and glucagon-like peptide 1 responses in patients with type 2 diabetes - Am J Clin Nutr 2003 Mar;77(3):605-11 - "Olive oil induced lower triacylglycerol concentrations and higher HDL-cholesterol concentrations than did butter, without eliciting significant changes in glucose, insulin, or fatty acids" - Olive oil is 76% omega-9.
  • I take Lopid (gemfibrozil) to lower my blood triglyceride and cholesterol levels, but I am concerned about the side effects. Is there anything natural that I can take instead? - Dr. Murray - "Pantethine has been shown to significantly reduce serum triglyceride (-32%), total cholesterol (-19%), and LDL-cholesterol (-21%) levels while increasing HDL-cholesterol (+23%) levels in several clinical trials"
  • Randomized controlled trial of the effect of n–3 fatty acid supplementation on the metabolism of apolipoprotein B-100 and chylomicron remnants in men with visceral obesity1 - Am. J. of Clin. Nutr., 2/03 - "randomly assigned to receive either fish oil capsules (4 g/d, consisting of 45% eicosapentaenoic acid and 39% docosahexaenoic acid as ethyl esters) or matching placebo ... Fish oil supplementation significantly (P < 0.05) lowered plasma concentrations of triacylglycerols (-18%) and VLDL apo B (-20%) and the hepatic secretion of VLDL apo B (-29%) compared with placebo" - Doing the math, 45% of 4 grams equals 1,800 mg of EPA,  39% of 4 grams equals 1,560 mg of DHA.  Three Mega Twin EPA at iHerb or Vitacosticon plus three Jarrow Max DHA at iHerb (the two strongest formulas I know) would be 2,100 mg EPA and 1,570 mg DHA.
  • Chromium For Insulin Function - Functional Foods & Nutraceuticals, 1/03 - "28 patients received 200mcg/day chromium picolinate for two months. Although there was no change seen in HDL or LDL cholesterol, triglyceride levels dropped 17.4 per cent"
  • Ispaghula Husk [psyllium] Nearly As Effective As Simvastatin For Hyperlipidemia - Doctor's Guide, 12/24/02 - "One group received 3.5 grams of ispaghula husk twice a day and the second group received 20 milligrams of simvastatin each day ... total cholesterol decreased by 15.8 percent and low-density lipoprotein (LDL) cholesterol decreased by 22.97 percent among patients taking ispaghula husk ... Triglycerides decreased by 20.89 percent and high-density lipoprotein (HDL) cholesterol increased by 10.69 percent in these patients ... Among patients taking simvastatin, total cholesterol decreased by 24.15 percent, LDL cholesterol decreased by 36.08 percent, triglycerides decreased by 20.47 percent and HDL cholesterol increased by 11.4 percent" - I've got that. See Drugstore.com psyllium productsicon.  3.5 grams is about one wafer (3.4 grams psyllium/wafer).  Plus 24 wafers runs about $4.49icon versus about $116icon for 30 of the 20 mg simvastatin.
  • Atkins diet good for cholesterol - USA Today, 11/18/02 - "After six months, the people on the Atkins diet had lost an average of 31 pounds, compared with 20 pounds on the AHA diet, and more people stuck with the Atkins regimen ... Total cholesterol fell slightly in both groups. However, those on the Atkins diet had an 11% increase in HDL, the good cholesterol, and a 49% drop in triglycerides. On the AHA diet, HDL was unchanged, and triglycerides dropped 22%. High triglycerides may raise the risk of heart disease" - That may be true but what about a diet devoid of anti-oxidants making you old before your time.  Plus, how much of that extra 11 pounds was water loss? - Ben
  • Silybin-Beta-Cyclodextrin Reduces Glucose, Triglyceride Levels In Diabetes With Liver Disease - Doctor's Guide, 11/12/02 - "Fasting blood glucose levels decreased by 14.7 percent from baseline in patients receiving silybin-beta-cyclodextrin ... Plasma triglycerides concentrations dropped from a mean 186 to 111 mg/dl at six months in those that received silybin-beta-cyclodextrin" - See iHerb and Vitacosticon silymarin products.
  • Fish Oil May Augment Atorvastatin As Treatment For Dyslipidemia In Obese, Insulin-Resistant Men - Doctor's Guide, 8/7/02 - "fish oils significantly decreased plasma levels of triglycerides and very low density lipoprotein-apoB, decreased the very low density lipoprotein-apoB secretion rate" - See Mega Twin EPA at iHerb or Vitacosticon.
  • Omega-3 Fatty Acids May Prevent Heart Disease By Improving Arterial Elasticity - Intelihealth, 7/25/02 - "Both omega-3 fatty acid supplement groups experienced significant declines in plasma total triacylglycerol concentrations"
  • Omega 3: Implications in human health and disease - PowerPak (39 page CME course for Registered Dietitians), exp. 8/1/03 - "A substantial body of evidence supports the use of fish oil in the treatment of hypertriglyceridemia.130 In normolipidemic subjects, daily dosages of 2-25 g of omega 3 fatty acids produced decreases in triglyceride concentrations of 20-60%. In patients with hypertriglyceridemia, decreases of up to 81% have been reported" - See Mega Twin EPA at iHerb or Vitacosticon.
  • Rice Bran Lowers Diabetic Blood Sugar - WebMD, 4/10/02 - "Rice bran was able to lower blood glucose by up to 30% in a small group of patients with type 1 or 2 diabetes ... also found that patients with elevated cholesterol who consumed 20 grams per day of stabilized rice bran lowered their total serum cholesterol and triglyceride levels between 5% and 15%"
  • question regarding your new cholesterol-lowering supplement, Policosanol - Life Extension Magazine, 11/01 - "Studies show that niacin (B3) in doses of 1.5 grams to 3 grams lower triglycerides levels and raise HDL concentrations. Those who tolerated higher doses of niacin (nicotinic acid) showed even more improvement in lipid levels. Some people taking just 1000 mg of flush-free niacin see an elevation in beneficial HDL. Green tea also has been shown to elevate levels of HDL while lowering serum triglyceride levels. In the Journal of Molecular Cell Biochemistry, curcumin has been demonstrated, in vivo, to decrease triglycerides and increase HDL. In a study published in 1989 by the Journal of Associated Physicians-India, 125 patients receiving gugulipid showed a drop of 16.8% in triglycerides, and a 60% increase in HDL cholesterol within three to four weeks. Make sure you are taking at least six Mega EPA fish oil capsules daily, as low dose fish oil may not adequately suppress triglycerides. Finally, there are some lifestyle changes you may wish to consider. If you are overweight, weight loss would be recommended, as it would help to lower triglycerides and raise HDL. Also, try reducing carbohydrates, which can raise triglycerides"
  • Product Review: Omega-3 Fatty Acids (EPA and DHA) from Fish/Marine Oils - ConsumerLabs.com, 11/20/01 - "It's been discovered that EPA and DHA may help prevent heart disease and atherosclerosis by lowering triglyceride levels, raising HDL ("good") cholesterol and, possibly "thinning" the blood ... By decreasing inflammation, EPA and DHA can also reduce the pain of rheumatoid arthritis ... Fish oils may also be useful in treating a host of conditions including bipolar (manic-depressive) disorder, Raynaud's phenomenon (abnormal sensitivity of hands and feet to cold), lupus, IgA nephropathy, kidney stones, chronic fatigue syndrome, Crohn's disease, cystic fibrosis, and ulcerative colitis ... EPA specifically may be helpful for schizophrenia, while DHA may be more helpful in reducing high blood pressure ... DHA may be helpful in the treatment of disorders such as attention deficit disorders, dyslexia, and cognitive impairment and dementia ... experts now believe that the American diet contains too little omega-3 fatty acids and too much omega-6 fatty acids"
  • A Fish Story - Nutrition Science News, 4/01 - "daily consumption of very low daily doses of EPA/DHA (120 mg/180 mg, about one standard fish oil capsule) in an enriched milk led to a 19 percent decrease in blood triglycerides and a 19 percent increase in HDL cholesterol after six weeks ... It is unclear whether EPA is superior to DHA, although EPA has proven more potent in relaxing cow coronary arteries and producing the vasodilator gas, nitric oxide, in vitro"
  • Fish Oil - The Natural Pharmacist - "Subsequent investigation found that the omega-3 fatty acids found in fish oil can lower blood triglyceride levels, "thin" the blood, and also decrease inflammation in various parts of the body."
  • Niacin Reduces Triglycerides, Increases Good Cholesterol In Diabetics - Doctor's Guide, 3/20/01 - "There had been concern that niacin use in diabetic patients might increase blood sugar levels ... but we didn't see that in our study ... Patients were randomised to receive placebo, 1,000 mg of niacin or 1,500 mg of prescription niacin ... Patients taking the active agent increased high-density lipoprotein (HDL) cholesterol by 20 to 24 percent compared with a 4 percent increase among the placebo patients. At the same time, triglycerides were reduced 15 to 29 percent in the patients on niacin compared with a 5 percent reduction among patients taking placebo"
  • Evaluation of the Antihyperlipidemic Properties of Dietary Supplements - Medscape, 4/1/01 - "[omega]-3 Fatty Acids ... Triglyceride concentrations decreased by 25% in subjects with normal triglyceride concentrations (< 177 mg/dl) and by 34% in those with elevated concentrations"
  • Evaluation of the Antihyperlipidemic Properties of Dietary Supplements - Medscape, 4/1/01 - "After 24 weeks of gugulipid treatment, total cholesterol levels decreased by 25.2 mg/dl, compared with a 7.6 mg/dl increase in the placebo group (p<0.01). The LDL was 16.9 mg/dl lower and 4.0 mg/dl higher, respectively ... In addition, a significant reduction in triglycerides was seen in the gugulipid-treated arm compared with placebo (-18 vs +5.5 mg/dl"
  • Using Creatine For More Than Muscles - Nutrition Science News, 10/99 - "A variety of published and unpublished research shows creatine may decrease tumor growth, increase body mass, decrease blood glucose, reduce triglycerides and cholesterol, extend exercise endurance in congestive heart failure patients, and even alter metabolism in people with neurodegenerative diseases such as Alzheimer's and Lou Gehrig's diseases"
  • Green Tea Lowers Cholesterol - Nutrition Science News, 10/99
  • Chromium Steels the Body Against Diabetes - Nutrition Science News, 2/99 - "The chromium treatment significantly lowered triglycerides"

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