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Anti-aging Research > Flavonoids
Flavonoids
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Specific Recommendation:
News & Research:
- Bioflavonoids - Compiled by Chad Bradshaw, Pharm.D
- Bioflavonoids
- The Natural Pharmacist
-
Flavonoids Are
Good For You - thenutritionreporter.com
-
A
Critical Look at the Flavonoids - thenutritionreporter.com
-
Chemopreventive Agents In Black Raspberries Identified - Science Daily,
1/8/09 - "anthocyanins, a class of flavonoids in
black raspberries, inhibited growth and stimulated apoptosis in the
esophagus of rats treated with an esophageal carcinogen" - [Nutra
USA]
-
Flavonoids’ heart health benefits in the blood vessels: Study - Nutra USA,
10/10/08 - "A daily dose of quercetin or (-)-epicatechin
led to improvements in endothelial function, a key marker of cardiovascular
health" - [Abstract]
-
Isoflavones and Flavonols Reduce Ovarian Cancer Risk - oncologystat.com,
8/22/08 - "Women with the highest flavonoid intake
had a 37% lower risk of ovarian cancer than those with the lowest intake. A
high intake of isoflavones, in particular, was associated with a 49%
decreased ovarian cancer risk"
-
Cocoa
for Diabetes? - WebMD, 5/27/08 - "Researchers
caution that the high-dose flavonol cocoa used in their study greatly
exceeds the typical U.S. dietary intake of 20 to 100 milligrams daily, and
you can't buy the extra-strength version in stores. Rather, they are
optimistic that flavonol-containing diets offer an innovative approach to
preventing heart disease"
-
Plant
Flavonoid In Celery And Green Peppers Found To Reduce Inflammatory Response In
The Brain - Science Daily, 5/20/08 - "The new study looked at luteolin
(LOO-tee-OH-lin), a plant flavonoid known to impede the inflammatory response in
several types of cells outside the central nervous system ... Those cells that
were also exposed to luteolin showed a significantly diminished inflammatory
response. Jang showed that luteolin was shutting down production of a key
cytokine in the inflammatory pathway, interleukin-6 (IL-6). The effects of
luteolin exposure were dramatic, resulting in as much as a 90 percent drop in
IL-6 production in the LPS-treated cells ... Inflammatory cytokines such as
interleukin-6 are very well known to inhibit certain types of learning and
memory that are under the control of the hippocampus, and the hippocampus is
also very vulnerable to the insults of aging ... If you had the potential to
decrease the production of inflammatory cytokines in the brain you could
potentially limit the cognitive deficits that result" - See
luteolin products at iHerb
 .
-
Plants' Flavonoids Have Beneficial Effect On Alzheimer's Disease, Study In
Mice Suggests - Science Daily, 5/7/08 -
"Researchers administered molecules called flavonoids, which are found in
certain fruits and vegetables, to a mouse model genetically programmed to
develop Alzheimer's disease. Using two of these molecules, luteolin and
diosmin, they were able to reduce the levels of a protein called amyloid-beta,
which forms the sticky deposits that build up in the brains of patients with
Alzheimer's"
-
Flavonoid intake and the risk of ischaemic stroke and CVD mortality in
middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor
Study - Br J Nutr. 2008 Apr 1;:1-6 - "men in the
highest quartile of flavonol and flavan-3-ol intakes had a relative risk of
0.55 (95 % CI 0.31, 0.99) and 0.59 (95 % CI 0.30, 1.14) for ischaemic
stroke, respectively, as compared with the lowest quartile. After
multivariate adjustment, the relative risk for CVD death in the highest
quartile of flavanone and flavone intakes were 0.54 (95 % CI 0.32, 0.92) and
0.65 (95 % CI 0.40, 1.05), respectively"
-
Flavonoid intake and liver cancer: a case-control study in Greece -
Cancer Causes Control. 2008 Mar 19 - "hepatocellular
carcinoma (HCC) ... Flavone intake, mostly derived from spinach and peppers,
was inversely associated with both virus positive (P-trend, 0.049) and virus
negative (P-trend, 0.084) HCC"
-
Could
foods prevent ovarian cancer? - MSNBC, 3/14/08 -
"Kaempferol — a flavonoid found in tea, broccoli, kale and spinach — and
luteolin — which is provided by peppers, carrots, cabbage and celery — were
both identified as cancer protective. Women who consumed the most of these
two flavonoids were 40 percent and 34 percent less likely, respectively, to
develop ovarian cancer compared to women who consumed the least ... A 2007
study published in the British Journal of Nutrition linked greater
consumption of carotenoid phytochemicals with a 67 percent lower risk of
ovarian cancer. This included not only beta-carotene, the oft-cited
carotenoid in deep-orange vegetables and fruits, but also alpha-carotene,
beta-cryptoxanthin, lutein and zeaxanthin — carotenoids found in a wide
range of red, orange, yellow and green vegetables" - See
Nature's Way, Multi-Carotene Anti-oxidant at iHerb.
-
Citrus flavanones show neuroprotection potential - Nutra USA, 1/21/08 -
"These results first demonstrate that the citrus
flavanones hesperidin, hesperetin, and neohesperidin, even at physiological
concentrations, have neuroprotective effects against H2O2-induced
cytotoxicity in PC12 cells ... These dietary antioxidants are potential
candidates for use in the intervention for neurodegenerative diseases ...
One such disease that is mentioned Alzheimer's disease" - [Abstract]
- See
hesperidin products at iHerb.
-
Chemical In Red Wine, Fruits And Vegetables Counters Unhealthy Effects Of
High-fat Foods - Science Daily, 1/2/08 -
"consuming polyphenols (natural compounds in red wine, fruits, and
vegetables) simultaneously with high-fat foods may reduce health risks
associated with these foods"
-
Flavonoid-rich Diet Helps Women Decrease Risk Of Ovarian Cancer -
Science Daily, 11/19/07 - "the researchers found a
40 percent reduction in ovarian cancer risk among the women with the highest
kaempferol intake, compared with women with the lowest intake. They also
found a 34 percent reduction in the risk of ovarian cancer among women with
the highest intake of luteolin, compared with women with the lowest intake"
-
Antioxidants may stop fat cells formation, says study - Nutra USA,
11/12/07 - "These results suggest that o-coumaric
acid and rutin targeted for adipocyte functions could be effective in
improving the symptoms of metabolic syndrome" - [Abstract]
-
Dark Chocolate Fights Heart Woes - WebMD, 11/5/07 -
"After two weeks, coronary circulation significantly
improved in participants who ate dark chocolate. There was no change among
those who ate white chocolate ... Cacao polyphenol contains four times as
many disease-fighting flavonoids per serving than red wine or tea"
-
Antioxidants May Fight Fat - WebMD, 11/2/07 -
"Those antioxidants didn't kill fat cells or slash the number of fat cells
in the test tubes. Instead, they made fat cells cut their production of
triglycerides, which are a heart hazard. The antioxidants did that by
curbing an enzyme needed to make triglycerides ... That particular enzyme
was most effectively reduced by the phenolic acid o-coumaric acid and the
flavonoid rutin"
-
Flavonoids Govern Cell Processes, Enhance Health - Science Daily,
10/11/07
-
Apples and onions may slash pancreatic cancer risk - Nutra USA, 10/1/07
- "Of the three individual flavonols, they report
that kaempferol was associated with the largest risk reduction (22 per cent)
across all participants"
-
Flavonoids In Orange Juice Make It A Healthy Drink, Despite The Sugar -
Science Daily, 7/18/07
-
Flavonoids in Orange Juice Make It a Healthy Drink, Despite the Sugar -
Doctor's Guide, 7/17/07 - "the two types of
flavonoids in orange juice -- hesperetin and naringenin -- inhibited ROS
generation by 52% and 77%, respectively ... Our data are relevant to
patients with diabetes ... because stress from ROS and inflammation are
increased significantly in this population and may contribute to development
of atherosclerosis"
-
Tea, Chocolate Chemical May Boost Memory - WebMD, 5/30/07 -
"studied epicatechin, which is a
type of antioxidant called a flavonol, in female mice ... The mice that
consumed epicatechin did better at memorizing the maze than the mice that
got no epicatechin. The mice that consumed epicatechin and also ran on their
running wheels had the best results of all"
-
Red
Wine Protects The Prostate - Science Daily, 5/25/07 -
"men who drink an average of four to
seven glasses of red wine per week are only 52% as
likely to be diagnosed with prostate cancer as
those who do not drink red wine ... when white wine was compared with red,
red had the most benefit ... But much of the speculation focuses on
chemicals—including various flavonoids and
resveratrol—missing from other alcoholic beverages"
-
Flavonol-rich diet may slash pancreatic cancer risk - Nutra USA, 4/16/07
-
Science stacks up for flavonoids for heart health - Nutra USA, 3/12/07
-
Studies Force New View On Biology Of Flavonoids - Science Daily, 3/5/07
-
Flavonoids linked to colorectal cancer protection - Nutra USA, 8/9/06 -
"A diet rich in certain flavonoids,
from eating plenty of fruit and vegetables, could reduce the risk of
colorectal cancer by over 40 per cent, says a large observational study from
Italy"
-
Researchers Reveal Apples' Protective Ways: Molecular Mechanism Of
Flavonoid-rich Fruit Discovered - Science Daily, 5/18/06 -
"the flavonoids in apples and apple
juice can inhibit signals in this pathway that would otherwise damage or
kill cells in the body"
-
Food Antioxidants, Vitamin D Fight Breast Cancer - HealthDay, 4/7/06 -
"postmenopausal women who consumed high
levels of flavonoids, a class of antioxidants found in plants, had a 45
percent lower risk of breast cancer ... Those who had the highest levels of
intake of kaempferol had a 38 percent decrease in the incidence of ovarian
cancer compared to women with the lowest levels of this flavonoid ... those
with the highest blood levels of a vitamin D metabolite known as
25-hydroxyvitamin D had a 50 percent reduced risk of breast cancer" -
[Science
Daily]
-
Grapefruit flavonoid could repair DNA, may protect against cancer -
Nutra USA, 2/15/06 - "Naringenin, a
flavonoid found in grapefruit and oranges, helped to repair damaged DNA in
cancer cells"
-
Flavonoids reduce exercise-induced oxidative stress - Nutra USA, 1/30/06
-
Heart-healthy Compound In Chocolate Identified - Science Daily, 1/20/06
- "epicatechin, one of a group of
chemicals known as flavanols, was directly linked to improved circulation
and other hallmarks of cardiovascular health"
-
Why Cocoa May Help
Heart Health - WebMD, 1/18/06 -
"cocoa's antioxidants -- called flavonoids -- coax the body into making more
nitric oxide, which relaxes the blood vessels"
-
Anticancer Agent in Veggies Shows Promise - WebMD, 10/21/05
-
Flavonoids May Inhibit Prostate Cancer - Science Daily, 10/21/05 -
"Our findings suggest that apigenin
could be developed as a promising agent against prostate cancer"
-
Chocolate May Help Smokers' Blood Vessels - WebMD, 9/29/05
-
Flavanols Key To Potential Chocolate Benefits - Science Daily, 9/29/05
-
Cocoa Is The New Red Wine: Shows Benefits For Coronary Heart Disease -
Science Daily, 8/12/05
-
Dark Chocolate May Cut High Blood Pressure - WebMD, 7/18/05 -
"With dark chocolate, 24-hour
systolic blood pressure dropped 12 points; diastolic blood pressure dipped
8.5 points ... Insulin sensitivity and LDL cholesterol also improved with
dark chocolate ... the dark chocolate we used had a high level of
flavonoids"
-
In
Chocolate, More Cocoa Means Higher Antioxidant Capacity - Science Daily,
4/23/05
-
Chocolate compound stops cancer cell cycle in lab - Nutra USA, 4/18/05 -
"the breast cancer cells stopped
dividing when treated with pentamer and that all four proteins were
inactivated ... the novel aspect here is that a pattern of several
regulatory proteins are jointly deactivated, probably greatly enhancing the
inhibitory effect compared to targeting any one of the proteins singly"
- Is
chocolate good for you? - MSNBC, 4/1/05 -
"One study that compared the total
antioxidant activity in single servings of cocoa, green tea, black tea and
red wine scored cocoa markedly higher than the rest"
-
Grapes May Stop Cancer Cells - WebMD, 3/31/05 -
"grapes (and lots of other fruits
and vegetables) are rich in antioxidant compounds called flavonoids ... We
are getting direct evidence that these components in grapes work
synergistically in fighting cancer"
-
Flavonoids work together to inhibit cancer cells - Nutra USA, 3/30/05 -
"Components in grapes, including
some newly identified ones, work together to dramatically inhibit an enzyme
crucial to the proliferation of cancer cells"
- Cocoa,
Flavanols and Cardiovascular Risk - Medscape, 11/29/04
-
Chocolate Said To Help Blood Vessels - Intelihealth, 8/30/04
- A Dark Chocolate a Day Keeps the Doctor Away -
WebMD, 6/1/04
- Chocolate - Food of the Gods? - Dr. Murray's
Natural Facts, 3/31/04
- Hot Cocoa May Prevent Heart Disease - WebMD,
11/6/03 - "Hot cocoa has more
disease-fighting antioxidants than tea or red wine ... black tea, green tea,
red wine, and cocoa are "major" sources of antioxidants called phenols and
flavonoids -- antioxidant chemicals found naturally in foods that can help
prevent chronic diseases such as heart disease and cancer" - Yeah,
but what about the sugar and calories. See
iHerb
or
Vitacost
green tea products. - Ben
- Disease-Fighting Benefits of Organic Foods -
WebMD, 3/6/03 -
"Recent evidence suggests that these micronutrients play important roles in
preventing cancer and heart disease ...
organic berries and corn had significantly more flavonoids than those
grown by conventional methods. And a third method -- called sustainable
farming -- yielded even higher flavonoid levels"
-
Plant Compound May Prevent Lung Cancer - WebMD, 2/19/03 -
"deguelin is found in several different types of plant species and is part
of a class of compounds in the flavonoid family ... deguelin appeared to
target the cancerous and precancerous cells, stopping their growth, while
having minimal effects on the normal, healthy cells ... deguelin is highly
specific and seems to work by zeroing in on a particular molecular pathway
associated with lung cancer
... the findings are especially interesting because there have been so few
agents that have shown potential to stop the progression of lung cancer"
-
Flavonoids found in chocolate may help reduce risk of heart disease -
HealthScout, 2/13/03 - "the main
flavonoids in cocoa -- flavan-3-ols -- are associated with a decreased risk
of cardiovascular disease ... Also,
a third of the fat in chocolate is made up of
oleic acid. That's a monosaturated fat, also found in olive oil, that's
been shown to benefit heart health"
- Which Chocolate Is Healthiest for Heart? - WebMD,
1/31/03
- Some Chocolate a Treat for the Heart - WebMD,
11/20/02
- Garlic, Chives Reduce Prostate Cancer - WebMD,
11/5/02 - "filling your diet with
garlic and scallions can help reduce the chance of this potentially
deadly cancer ... Garlic and scallions, along with onions, leeks, chives,
and shallots, are rich in flavonols, substances in plants that have been
shown to have antitumor
effects. All of these vegetables have previously been linked to lower risks
of cancers of the stomach, colon, esophagus, and perhaps breast ... although
fruits and vegetables slightly reduced prostate
cancer, the lower risk associated with
allium
vegetables was much more pronounced"
- Apple a Day Gets Rid of Doctor and More - WebMD,
9/13/02 -
"People eating foods rich in a variety of flavonoids -- plant products that
act like antioxidants -- were less likely to have heart disease, stroke, and
asthma. Type 2 diabetes also appeared to be less common in this group. Plus,
men that ate flavonoids had less lung and prostate cancers"
- Say Cheers: White Wine May Aid Lungs - Doctor's
Guide, 5/21/02
- The Lungs Favor White Wine - WebMD, 5/20/02 -
"those studies have shown that a daily dose of 1 to 3 glasses of red wine
can improve
cardiovascular health ... We found that white wine intake was strongly
associated with better [lung] function ... One glass of wine per day equaled
a 1.5% higher lung function, adding one or two more years to the person's
lifetime; 3 glasses a day improved lung capacity by 3% ... He speculates
that white wine drinkers have higher levels of vitamin
antioxidants in their blood" - Also see
grape seed extract/Pycnogenol.
- Drinking Tea May Help Prevent Heart Attacks -
Doctor's Guide, 5/9/02 - "Drinking
more tea and increasing flavonoid intake may
help primary prevention of
ischaemic heart disease ...
The intake of the dietary flavonoids quercetin,
kaempferol
and myricetin
was significantly associated inversely with fatal myocardial infarction only
in upper tertiles
of intake"
- Tea Prolongs Survival After Heart Attack - WebMD,
5/6/02 - "Researchers say the
findings add to a growing notion that the antioxidant-rich flavonoids found
in black and
green teas prevent
heart disease. But this is the first study to suggest that drinking tea
can actually protect the heart after damage has already occurred"
- Cocoa: The Next Health Drink? - WebMD, 2/15/02
- Got Anthocyanins? - Nutrition Science News, 12/01
-
The Wizard is Oz - Life Extension Magazine, 11/01 -
"Best-selling author and nutritional guru to the rich and famous, Oz Garcia
is singing the praises of the Life Extension Foundation and its products in
his newest book,
The
Healthy High Tech Body, published in September 2001 ... Supplements at
the top of Garcia's list of recommendations ...
DHA ... NADH ...
Alpah
Lipoic Acid
... Acetyl-L-Carnitine ... An expanded list of his
recommendations includes lycopene,
gamma tocopherol, vinpocetine, SAMe,
folic acid, carnosine,
glutathione, DMAE, Huperzine A,
probiotics, MSM,
secretagogues, arginine pyroglutamate,
IP-6, bioflavonoid formulas and
grape skin/seed extracts"
- Chocolate Boosts 'Good' Cholesterol And Protects Against Heart Disease
- Intelihealth, 10/25/01
- Chocolate Is Good for the Heart - WebMD, 10/23/01
- "chocolate ... has loads of
antioxidants in the form of flavonoids, which are known to reduce
cardiovascular risk ... certain cocoas and chocolates -- taken in small,
regular doses -- seem to raise HDL, or the "good" cholesterol, while
lowering the "bad" variety called
LDL, which can clog the
arteries ... half the group ate a "typical American diet" that was purposely
low in flavonoids. The other half ate the "experimental diet," which
essentially was the typical American diet plus cocoa powder (3/4 of an
ounce) and dark chocolate (half an ounce) ... They found that
LDL
cholesterol was oxidized 8% more slowly -- and that HDL cholesterol increased
by 4% -- after the people ate chocolate"
-
Pomegranates a Top Antioxidant - Nutrition Science News, 3/01 -
"pomegranate juice exhibits three times greater antioxidant activity than
other bioflavonoids such as red wine or green tea"
-
Dieticians get sweet words on chocolate - CNN, 10/17/00
-
Natural COX-2 Inhibitors The Future of Pain Relief - Nutrition Science
News, 8/00
-
Good News For Chocoholics - WebMD, 7/17/00
-
Researchers Suggest Daily Tea May Fortify Bones Of Elderly Women -
Intelihealth, 4/7/00
-
Wine or Welch's? Grape juice provides health benefits without alcohol -
CNN, 3/31/00
-
Flavonoids may help fight cancer, study finds - CNN, 3/30/00
-
Cancer Prevention Diet - Nutrition Science News, 8/99
-
Will wine help your heart? - CNN, 7/6/99
-
Second Sight - Nutrition Science News,
4/99
- Scientists
See Anti-Aging, Cancer-Fighting Properties In Wild Blueberries
- Doctor's Guide, 9/23/97
- Orange,
Grapefruit Juice A Powerful Anti-Cancer Tool? -
Doctor's Guide, 7/28/97
- Study
Reveals New Antioxidant; More Potent than C, E and Beta-Carotene
- Doctor's Guide, 4/8/97
Abstracts:
-
Pure
dietary flavonoids quercetin and (-)-epicatechin augment nitric oxide
products and reduce endothelin-1 acutely in healthy men - Am J Clin Nutr.
2008 Oct;88(4):1018-25 - "Dietary flavonoids, such
as quercetin and (-)-epicatechin, can augment nitric oxide status and reduce
endothelin-1 concentrations and may thereby improve endothelial function"
-
Luteolin reduces IL-6 production in microglia by inhibiting JNK
phosphorylation and activation of AP-1 - Proc Natl Acad Sci U S A. 2008
May 19 - "Luteolin consumption reduced LPS-induced
IL-6 in plasma 4 h after injection. Furthermore, luteolin decreased the
induction of IL-6 mRNA by LPS in hippocampus but not in the cortex or
cerebellum. Taken together, these data suggest luteolin inhibits LPS-induced
IL-6 production in the brain by inhibiting the JNK signaling pathway and
activation of AP-1 in microglia. Thus, luteolin may be useful for mitigating
neuroinflammation"
-
Dietary flavonoid intake and risk of cancer in postmenopausal women: The
Iowa Women's Health Study - Int J Cancer. 2008 May 19 -
"After multivariable adjustment, lung cancer
incidence was inversely associated with intakes of flavanones (HR = 0.68;
95% CI: 0.53-0.86, all results highest vs. lowest quintile) and
proanthocyanidins (HR = 0.75; 95% CI: 0.57-0.97). Among current and past
smokers, those with intakes in the highest quintile for flavanones (HR =
0.66; 95% CI: 0.50-0.86), and proanthocyanidins (HR = 0.66; 95% CI;
0.49-0.89) had significantly lower lung cancer incidence than those in the
lowest quintile. Similar associations were not seen in never smokers.
Isoflavone intake was inversely associated with overall cancer incidence (HR
= 0.93, 95% CI: 0.86-1.00). This study provides further support for a
beneficial effect of flavonoid intake on lung cancer risk, especially among
current and past smokers"
-
Flavonoids and ovarian cancer risk: A case-control study in Italy - Int
J Cancer. 2008 May 19 - "In logistic regression
models including study center, education, year of interview, parity, oral
contraceptive use and family history of ovarian or breast cancer or both, an
inverse relation with significant trend in risk was found between ovarian
cancer and flavonols [odds ratio (OR), 0.63; 95% confidence intervals (CI)
0.47-0.84] as well as isoflavones (OR, 0.51; 95% CI, 0.37-0.69), comparing
the highest versus the lowest quintile. Further adjustment for fruit and
vegetable intake did not modify these associations, suggesting that
isoflavones and flavonols may have a distinct role in explaining the effect
of fruit and vegetable against ovarian cancer. On the basis of our findings
and the relevant literature, we infer that isoflavones, and perhaps
flavonols, may have favorable effects with respect to ovarian cancer risk"
-
Serum C-reactive protein concentrations are inversely associated with
dietary flavonoid intake in u.s. Adults - J Nutr. 2008 Apr;138(4):753-60
- "Among the flavonoid compounds investigated,
quercetin, kaempferol, malvidin, peonidin, daidzein, and genistein had
inverse associations with serum CRP concentration"
-
Neuroprotective Effects of the Citrus Flavanones against H2O2-Induced
Cytotoxicity in PC12 Cells - J Agric Food Chem. 2008 Jan 12 -
"the citrus flavanones hesperidin, hesperetin, and
neohesperidin, even at physiological concentrations, have neuroprotective
effects against H 2O 2-induced cytotoxicity in PC12 cells. These dietary
antioxidants are potential candidates for use in the intervention for
neurodegenerative diseases" - See
Hesperidin products at iHerb.
-
Effects of flavonoids and phenolic acids on the inhibition of adipogenesis
in 3T3-L1 adipocytes - J Agric Food Chem. 2007 Oct 17;55(21):8404-10 -
"These results suggest that o-coumaric acid and
rutin targeted for adipocyte functions could be effective in improving the
symptoms of metabolic syndrome"
-
Flavonoids and the risk of renal cell carcinoma - Cancer Epidemiol
Biomarkers Prev. 2007 Jan;16(1):98-101 - "After
adjustment for major recognized confounding factors and total energy intake,
the odds ratios for subjects in the highest versus the lowest quintile of
intake were 0.80 [95% confidence interval (95% CI), 0.58-1.11] for total
flavonoids, 0.76 (95% CI, 0.56-1.03) for isoflavones, 0.94 (95% CI,
0.60-1.47) for anthocyanidins, 0.77 (95% CI, 0.56-1.06) for flavan-3-ols,
0.90 (95% CI, 0.67-1.21) for flavanones, 0.68 (95% CI, 0.50-0.93) for
flavones, and 0.69 (95% CI, 0.50-0.95) for flavonols"
-
Flavonoids and laryngeal cancer risk in Italy - Ann Oncol. 2007 Mar 19 -
"Significant inverse relations were
found for the highest versus the lowest quintile of intake for flavan-3-ols
(OR = 0.64), flavanones (OR = 0.60), flavonols (OR = 0.32) and total
flavonoids (OR = 0.60)"
-
Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin,
and diosmin - J Agric Food Chem. 2005 Aug 24;53(17):6791-7 -
"The greatest reduction in the
number of metastatic nodules (52%) was obtained with diosmin"
-
Flavonoid-rich dark chocolate improves endothelial function and increases
plasma epicatechin concentrations in healthy adults - J Am Coll Nutr.
2004 Jun;23(3):197-204 - "Flavonoid-rich dark chocolate
improves endothelial function"
-
Grape juice, but not orange juice or grapefruit juice, inhibits human
platelet aggregation - J Nutr. 2000 Jan;130(1):53-6
-
Inhibition of aromatase activity by flavonoids - Arch Pharm Res. 1999
Jun;22(3):309-12
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