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Home > Anti-aging Research > Hawthorn

Hawthorn (Crataegus laevigata or Crataegus oxyacantha)

Specific Recommendations:

News & Research:

  • Benefit-Risk Assessment of Crataegus Extract WS 1442 - Medscape, 2/5/18 - "Preparations from Crataegus (hawthorn) have a long history in the treatment of heart failure ... Changes in heart failure-associated symptoms and health-related QoL during treatment with WS 1442 were assessed in several trials.[37,43,45,56,57] In two trials, the von Zerssen Complaints List,[61] a validated self-rating questionnaire assessing 24 general symptoms, some of which (e.g., shortness of breath, fatigue) are particularly important in heart failure, was used. In the study reported by Leuchtgens,[56] which included 30 patients (15 per group), those treated with WS 1442 for 8 weeks showed a significantly more pronounced decrease of the total score of the scale than those in the placebo group (mean value difference 7.3 points, 95% CI 0.9–13.7, according to[52]). In the study of Tauchert[37] in which 209 patients received 1800 or 900 mg/day WS 1442 or placebo for 16 weeks, both WS 1442 dosages showed a significantly more pronounced total score decrease compared to placebo" - See hawthorn betty extract at Amazon.com.
  • Herbal Remedy, Hawthorn Extract, Can Help The Heart, Review Finds - Science Daily, 1/22/08 - "The trials involved a total of 855 patients and the data indicated that hawthorn extract: ... improved maximal workload ... increased exercise tolerance ... reduced oxygen consumption by the heart ... reduced shortness of breath and fatigue"
  • Hawthorn Extract Helps People with Chronic Heart Failure - Doctor's Guide, 8/7/03
  • Hawthorn Extract Improves Exercise Tolerance in People with Congestive Heart Failure - New Hope Natural Media, 7/25/02 - "Hawthorn may be a safer substance to consider in cases of mild to moderate heart failure, as an alternative to, or in addition to, prescription medications ... German scientists studied the effect of 240 mg per day of a hawthorn extract or placebo for three months in 39 people with moderate heart failure ... In the group taking hawthorn, exercise tolerance on a stationary bicycle improved by almost 11%, but decreased by about 17% in those taking a placebo. Those taking hawthorn also reported feeling better overall"
  • Hawthorn: Old Reliable for the Heart - Nutrition Science News, 8/00
  • Does hawthorn cure congestive heart failure? - Nutrition Science News, 6/00
  • Sidestep Heart Disease - Nutrition Science News, 3/99

News & Research:

  • Hawthorn Fruit Attenuates Atherosclerosis by Improving the Hypolipidemic and Antioxidant Activities in Apolipoprotein E-Deficient Mice - J Atheroscler Thromb. 2013 Oct 11 - "ApoE-/- mice were divided into a control group (n=10) and hawthorn fruit group (n=10) ... The hawthorn fruit group mice developed significantly decreased (p<0.05) atherosclerotic lesions. The levels of serum lipids decreased significantly (p<0.05) and the levels of cholesterol/triglycerides, including very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), decreased in the hawthorn fruit group ... The hepatic fatty acid synthase (FAS) and sterol regulatory element binding protein-1c (SREBP-1c) mRNA levels were reduced by 42% (p<0.05) and 23% p<0.05) in the mice fed the hawthorn fruit diet compared with that observed in the mice fed a standard diet" - See hawthorn products at Amazon.com.
  • Immunomodulatory effect of Hawthorn extract in an experimental stroke model - J Neuroinflammation. 2010 Dec 30;7(1):97 - "middle cerebral artery occlusion-(MCAO) induced stroke ... In summary, Hawthorn extract helped alleviate pro-inflammatory immune responses associated with I/R-induced injury, boosted IL-10 levels, and increased Foxp3-positive Tregs in the brain, which may have aided in suppression of activated inflammatory cells. Such treatment also minimizes apoptotic cell death by influencing STAT-3 phosphorylation and Bcl-xL expression in the brain. Taken together, the immunomodulatory effect of Hawthorn extract may play a critical role in the neuroprotection observed in this MCAO-induced stroke model"
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