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Anti-aging Research > Alpha Lipoic Acid
Alpha Lipoic Acid
Specific Recommendations:
News & Research:
-
Alpha Lipoic Acid
- Vitacost Health Library - "Chronic
administration of alpha lipoic acid in animals has interfered with the
actions of the vitamin, biotin. Whether this has significance for humans
remains unknown"
- Alpha Lipoic Acid - The
Natural Pharmacist
- Lipoic
Acid, The Unique Antioxidant - Ray Sahelian, M.D.
- I
have noticed more and more articles on the benefits of lipoic acid. What is
your opinion of it? - Dr. Murray
-
Is there any advantage to taking a timed-release alpha-lipoic acid
supplement over an immediate release capsule? - Dr. Murray
-
Alpha-Lipoic
Acid - thenutritionreporter.com
-
New
Approach Discovered To Lowering Triglycerides - Science Daily, 3/30/09 -
"In the lab animals, supplements of lipoic acid lowered
triglyceride levels up to 60 percent ... supplements of lipoic acid appeared to
affect triglyceride levels through two pathways. After eating, lipoic acid
supplementation increased the rate of disappearance of triglycerides in the
bloodstream. And supplements also reduced the genetic expression of enzymes in
the liver that synthesize triglycerides ... Lipoic acid supplements have in
various studies been shown to be an appetite suppressant ... The amount of
lipoic acid supplementation used in these laboratory experiments would equate to
about two grams per day for a 150-pound person"
-
Lipoic acid and carnitine combo show diabetes potential - Nutra USA, 2/18/08
- [Abstract] -
"the combination of LA and LCAR increased the mass,
oxygen consumption, mitochondrial DNA expression, and fatty acid oxidation in
the fat cells ... However, the treatments with LA or ALC alone at the same
concentrations showed little effect on mitochondrial function and biogenesis ...
Lipoic acid and acetyl-L-carnitine have become very hot after our reports on the
complementary effects on improving memory and ambulatory activity in old rats"
-
Lipoic
Acid Could Reduce Atherosclerosis, Weight Gain - Science Daily, 1/14/08 -
"lipoic acid supplements reduced atherosclerotic lesion
formation in two types of mice that are widely used to study cardiovascular
disease, by 55 percent and 40 percent, respectively. The supplements were also
associated with almost 40 percent less body weight gain, and lower levels of
triglycerides in very low-density lipoproteins" - See
Doctor's Best, Best Stabilized R-Lipoic Acid Na-RALA
at iHerb
 .
-
Lipoic
Acid Explored As Anti-aging Compound - Science Daily, 5/17/07 -
"mice supplemented with lipoic acid have
a cognitive ability, behavior, and genetic expression of almost 100
detoxification and antioxidant genes that are comparable to that of young
animals"
-
Alpha-Lipoic Acid Supplements review - ConsumerLab.com, 5/16/07 -
"two alpha lipoic acid supplements
contained significantly less of this ingredient than promised on their
labels"
-
Four
powerhouse nutrients - Functional Foods and Nutraceuticals, 4/05 -
"L-carnitine shuttles fuel into
cells to be burned as energy; coenzyme Q10 sparks the energy within the
cells; ribose is a component of adenosine triphosphate (ATP); and
alpha-lipoic acid increases ATP levels"
-
R-Dihydro-Lipoic Acid - The Optimal Form of Lipoic Acid - Life Extension
Magazine, 2/05
-
Testing of Alpha-Lipoic Acid Supplements By Consumerlab.com Finds Most Meet
Label Claims :: Natural and Nutritional Products Industry Center :: News
- NPI Center, 12/21/04 -
"one of 21 alpha-lipoic acid
supplements recently tested contained only 15% of the alpha-lipoic acid that
it claimed ... There is fairly good evidence that alpha-lipoic acid can be
help people with diabetes"
- The Advantage of Single Daily Dosages of Herbal Medicines
- Dr. Murray's Natural Facts, 9/15/04 - "Based upon the clinical research over the last 30 years and the
pharmacokinetics of immediate-release alpha-lipoic acid, it appears to be
obviously superior to the timed-release product"
- Antioxidant [alpha]-Lipoic Acid Provides Relief for Diabetic Polyneuropathy
- Doctor's Guide, 6/20/03 - "After 3
weeks, alpha-lipoic acid had a 24.1% improvement over placebo ... for TSS
[Total Symptom Score] and 16.0% for NIS [Neuropathy
Impairment Score]"
- Alpha-Lipoic Acid Effective Against Burning Mouth Syndrome
- New Hope Natural Media, 5/15/03
- Alpha Lipoic Acid Helping the Fight against Diabetes
- Physician's Weekly, 5/12/03 - "the
over-the-counter antioxidant supplement alpha lipoic acid has been effective
against the burning, numbness and pain that often is associated with
diabetic neuropathy. The antioxidant
works mainly as a pain medication and was clinically shown to have few side
effects"
- Antioxidant Soothes Diabetic Neuropathy - WebMD,
4/11/03 - "Alpha
lipoic acid seems to actually change the metabolism of the nerve or
blood supply to the nerve ... It is a very strong antioxidant and it is
assumed that oxidation plays a role in the development of diabetes ... This
means the substance -- produced in very small amounts by the body and also
found in foods such as potatoes and red meat -- protects against damage by
cell-ravaging "free radicals." This oxidation process is implicated in
various diseases, including heart disease, cancer, and
neurologic conditions
including Parkinson's and Alzheimer's ... alpha lipoic acid improves the
function of cell "transporters" that carry and distribute glucose. "This
helps insulin do its role,"" - See
iHerb
or Vitacost
alpha lipoic acid products.
- Alpha-Lipoic Acid Helpful in Diabetic Neuropathy -
Medscape, 3/7/03 - "Alpha-lipoic
acid (ALA) rapidly and significantly reduces sensory symptoms and pain of
diabetic neuropathy"
- 12 Ways to Feel and Look Younger - WebMD, 10/25/02
- "In addition
to the effective antioxidant vitamin C, Morris says CoQ10, vitamin E, alpha
lipoic acid (another antioxidant), and perhaps some of those "mental acuity"
mixtures in the health-food store should be in your medicine cabinet"
-
ALC and Alpha-Lipoic Acid - Dr. Janson's Newsletter, 7/02 -
"The recent studies in rats show that ALC
(especially when combined with the antioxidant alpha-lipoic acid) can
protect the brain from the oxidative damage related to aging, and can
protect the mitochondrial membranes ... when older animals are supplemented
with ALC and lipoic acid they are more physically active, have better
short-term memory, and overall enhanced cognitive function. (They also have
better liver function because of the same protection of the mitochondria,
with increased mitochondrial metabolism and reduced oxidative damage.) ...
It appears that these nutrients also help the heart, especially when taken
together. While ALC helps restore cardiac carnitine levels, and improves
cardiac energy, the aging heart also becomes sensitive to oxidative stress.
For protection from such stress, you need to combine the ALC with
alpha-lipoic acid (LA) ... It is apparent that the accelerated aging that
results from lifestyle choices, stress, and oxidative exposures, can be
slowed or even reversed"
-
Do Anti-aging Supplements Really Work? - Life Extension Magazine, 6/02 -
"The National Academy of Sciences has published three new reports showing
that aging may be partially reversible with currently available supplements"
-
Putting Antioxidants To Use In Functional Formulas - Functional Foods &
Nutraceuticals, 5/02 - "Clinical
studies have found that it can improve insulin function, helping to improve
glucose tolerance in people with diabetes.15,16
Some researchers have suggested that long-term use of alpha-lipoic acid may
help prevent adult-onset diabetes"
-
The Wizard is Oz - Life Extension Magazine, 11/01 -
"Best-selling author and nutritional guru to the rich and famous, Oz Garcia
is singing the praises of the Life Extension Foundation and its products in
his newest book,
The
Healthy High Tech Body, published in September 2001 ... Supplements at
the top of Garcia's list of recommendations ...
DHA ... NADH ... Alpah Lipoic Acid ...
Acetyl-L-Carnitine ... An expanded list of his recommendations includes
lycopene, gamma tocopherol, vinpocetine,
SAMe, folic acid,
carnosine,
glutathione, DMAE, Huperzine A,
probiotics, MSM,
secretagogues, arginine pyroglutamate,
IP-6, bioflavonoid formulas and
grape skin/seed extracts"
- The Hard-Liver's Guide to the Liver - WebMD,
10/8/02
-
The Prediabetic Epidemic - Nutrition Science News, 3/01 -
"Supplements to Regulate Glucose and Insulin ... Alpha-Lipoic Acid ... Only
recently have researchers understood its antioxidant actions quench free
radicals responsible for many diabetic complications. It also lowers glucose
levels—by 10 to 30 percent—and improves insulin function ...
Vitamin E ... Vitamin C ...
Chromium ...
Silymarin"
-
Sustain the Brain - Nutrition Science News, 2/01 -
"ALA may protect the body from oxidative damage by enhancing detoxifying
agents such as glutathione, which occurs in the brain and serves as an
antioxidant in these tissues ... Results of animal studies demonstrate that
ALA can reduce damage to neurons caused by toxic substances that are
by-products of inflammatory processes.12 Another animal study
showed memory improvement in aged rats given ALA ... Clinical trials
conducted in Germany have shown ALA to be valuable for treating diabetic polyneuropathy, a disease involving the peripheral nerves. Supplementation
was shown to improve motor and sensory nerve conduction"
- ALA Eases Diabetic Neuropathy Symptoms - Nutrition
Science News, 11/00
- Some Diabetics Buck Tradition and Turn to Herbs -
WebMD, 10/9/00 - "Researchers have
submitted study results to the journal Diabetes Care for another natural
product -- alpha lipoic acid, known by the brand name Glucotize.
The product "lowers blood sugar levels, which is excellent," ... "Because
that's what causes a lot of diabetic complications.""
-
Lipoic Acid: The Universal Antioxidant - Nutrition Science News, 10/00
-
Staying Young Forever, Putting new research findings into practice -
Life Extension Foundation, 12/99 -
"lipoic acid is the only antioxidant that can boost the level of
intracellular glutathione, a cellular antioxidant of tremendous importance.
Besides being the body's primary water-soluble antioxidant and a major
detoxification agent, glutathione is absolutely essential for the
functioning of the immune system"
-
Alpha Lipoic Acid For Diabetes, Atherosclerosis And Aging - Life
Extension Magazine, 3/96
Abstracts:
-
Dietary
lipoic acid supplementation can mimic or block the effect of dietary restriction
on life span -Mech Ageing Dev. 2008 Apr 22;129(6):341-348 -
"Ad libitum feeding a diet supplemented with lipoic acid
can therefore act as mimetic of DR to extend survival"
-
Switching from pathogenetic treatment with alpha-lipoic acid to gabapentin and
other analgesics in painful diabetic neuropathy: a real-world study in
outpatients - J Diabetes Complications. 2008 Apr 8 - "The daily costs for alpha-lipoic acid were considerably lower than those for
gabapentin or several frequently used drug combinations. The frequency of
outpatient visits was 3.8 times per 3 months during the treatment period with
alpha-lipoic acid, while it increased to 7.9 per 3 months after switching to
gabapentin or the other pain medications. In conclusion, switching from
long-term treatment with alpha-lipoic acid to central analgesic drugs such as
gabapentin in painful diabetic neuropathy was associated with considerably
higher rates of side effects, frequencies of outpatient visits, and daily costs
of treatment. The pathogenic treatment option represents for the practicing
diabetologist an effective, safe, and cost-effective treatment option for the
majority of patients with diabetic polyneuropathy" - See alpha lipoic acid products at iHerb.
-
Lipoic acid supplementation and endothelial function - Br J Pharmacol.
2008 Mar 17 - "Endothelial dysfunction is caused by
all the recognized cardiovascular risk factors and has been implicated in
the complex processes leading to the initiation and progression of
atherosclerosis. Short-term treatment with lipoic acid is shown in the
current issue of the British Journal of Pharmacology to improve endothelial
function of aortic rings of old rats. The age-related decrease in
phosphorylation of nitric oxide synthase and Akt was improved by lipoic acid
supplementation. The improved phosphorylation status may have been due to
reduced activity of the phosphatase PPA2, associated with decreased levels
of endothelial ceramide induced by lipoic acid. Neutral sphingomyelinase
activity was also reduced by lipoic acid, which was due, at least in part,
to increased glutathione levels in endothelial cells"
-
Lipoic acid significantly restores, in rats, the age-related decline in
vasomotion - Br J Pharmacol. 2008 Feb 25 - "In
old animals, endothelium-dependent relaxation in aortic rings was decreased,
GSH levels and its redox state in aortic endothelia were over 30% lower and
nSMase activity and endothelial ceramide levels were three-fold increased,
relative to young (2-4 mo) rats. LA treatment of old animals improved
relaxation in aortic rings, reversed the changes in endothelial GSH, in
nSMase activities and in ceramide levels. Similar effects on GSH levels and
nSMase activity in old rats were also induced by treatment with GSH
monoethylester. Activation (by phosphorylation) of eNOS was decreased by
about 50% in old rats and this age-related decrease was partially reversed
by LA treatment" - See
Doctor's Best, Best Stabilized R-Lipoic Acid Na-RALA
at iHerb.
-
Effect of Co-enzyme Q10 and Alpha-Lipoic Acid on Response of Rabbit Urinary
Bladder to Repetitive Stimulation and In Vitro Ischemia - Urology. 2008
Feb 15 - "CoQ10 showed no protective effect.
alpha-LA resulted in increased contractile responses of the control bladder
and showed a moderate protective effect for all forms of stimulation. The
combination, however, showed a significantly greater increase in the
contraction of the control bladder and a greater protective effect than
alpha-LA alone"
-
R-alpha-Lipoic acid and acetyl-L: -carnitine complementarily promote
mitochondrial biogenesis in murine 3T3-L1 adipocytes - Diabetologia.
2008 Jan;51(1):165-74 - "Treatments with the
combination of LA and ALC at concentrations of 0.1, 1 and 10 mumol/l for 24
h significantly increased mitochondrial mass, expression of mitochondrial
DNA, mitochondrial complexes, oxygen consumption and fatty acid oxidation in
3T3L1 adipocytes. These changes were accompanied by an increase in
expression of Pparg, Ppara and Cpt1a mRNA, as well as increased expression
of peroxisome proliferator-activated receptor (PPAR) gamma coactivator 1
alpha (Ppargc1a), mitochondrial transcription factor A (Tfam) and nuclear
respiratory factors 1 and 2 (Nrf1 and Nrf2). However, the treatments with LA
or ALC alone at the same concentrations showed little effect on
mitochondrial function and biogenesis" - See
Doctor's Best, Best Stabilized R-Lipoic Acid Na-RALA
at iHerb
and
Doctor's Best acetyl-l-carnitine at iHerb.
-
The antioxidant alpha-lipoic acid improves endothelial dysfunction induced
by acute hyperglycaemia during OGTT in impaired glucose tolerance - Clin
Endocrinol (Oxf). 2007 Dec 7
-
Dietary lipoic acid-dependent changes in the activity and mRNA levels of
hepatic lipogenic enzymes in rats - Br J Nutr. 2007 Dec 7;:1-9 -
"Lipoic acid profoundly decreased serum and liver
concentrations of TAG, and also lowered serum concentrations of phospholipid
and NEFA, and the concentration of cholesterol in the liver. A hypoglycaemic
effect of this compound was also observed. Lipoic acid dose-dependently
decreased the activity and mRNA levels of fatty acid synthase, ATP-citrate
lyase, glucose 6-phosphate dehydrogenase, malic enzyme and pyruvate kinase
in the liver despite that reductions were considerably attenuated in the
NADPH-producing enzymes. This compound also dose-dependently lowered the
mRNA levels of spot 14, adiponutrin, stearoyl-CoA desaturase 1, and Delta5-
and Delta6-desaturases. In addition, lipoic acid dose-dependently lowered
serum concentrations of insulin and leptin, but increased those of
adiponectin. Lipoic acid appeared to reduce hepatic lipogenesis and hence
decreases serum and liver lipid levels. Alterations in serum concentrations
of insulin and (or) adiponectin may trigger this consequence" - See
Doctor's Best, Best Stabilized R-Lipoic Acid Na-RALA
at iHerb.
-
The effect of alpha-lipoic acid on symptoms and skin blood flow in diabetic
neuropathy - Diabet Med. 2007 May 8 - "study suggests that alpha-lipoic
acid, a potent antioxidant, improves symptoms of diabetic neuropathy"
-
Oral Treatment With {alpha}-Lipoic Acid Improves Symptomatic Diabetic
Polyneuropathy: The SYDNEY 2 trial - Diabetes Care. 2006
Nov;29(11):2365-2370 - "Oral
treatment with ALA for 5 weeks improved neuropathic symptoms and deficits in
patients with DSP. An oral dose of 600 mg once daily appears to provide the
optimum risk-to-benefit ratio"
-
Treatment for diabetic mononeuropathy with alpha-lipoic acid - Int J
Clin Pract. 2005 Jun;59(6):645-50 - "alpha-lipoic acid appears to be an effective drug in the treatment for not
only peripheral and autonomic diabetic neuropathy, but also diabetic
mononeuropathy of the cranial nerves leading to full recovery of the
patients" - See
iHerb
or Vitacost
alpha lipoic acid products.
-
Memory loss in old rats is associated with brain
mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding
acetyl-L-carnitine and/or R-alpha -lipoic acid
- Proc Natl Acad Sci U S A 2002 Feb 19;99(4):2356-2361 -
"Electron microscopic studies in the hippocampus showed that
ALCAR and/or LA reversed age-associated mitochondrial structural decay"
Other possible alpha lipoic acid
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