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Anti-aging Research > L-Arginine
News & Research:
Naturally occurring amino acid could improve oral health - Science
Daily, 5/7/15 - "in the lab L-arginine -- found in
red meat, poultry, fish and dairy products, and is already used in dental
products for tooth sensitivity--stopped the formation of dental plaque ...
nearly 24 percent of adults in the United States have untreated dental
caries, and about 39 percent have moderate-to-severe periodontitis, a number
that rises to 64 percent for those over age 65 ... It appears arginine can
change how cells stick together, and can trigger bacteria within biofilms to
alter how they behave so that they no longer stick to surfaces" - See
L-arginine products at Amazon.com.
Chowing down on watermelon could lower blood pressure, study suggests -
Science Daily, 4/3/14 - "the group was divided into
two. For the first six weeks, one group was given four grams of the amino
acid L-citrulline and two grams of L-arginine per day, both from watermelon
extract. The other group was given a placebo for 6 weeks ... consuming
watermelon had a positive impact on aortic blood pressure and other vascular
parameters" - See
L-citrulline at Amazon.com
L-arginine products at Amazon.com.
Arginine Therapy Shows Promise for Sickle Cell Pain - Science Daily,
9/16/13 - "A deficiency of nitric oxide, a potent
vasodilator, has been identified in sickle cell disease and may contribute
to episodes of blocked vessels and pain. Since arginine is a building block
of nitric oxide, researchers hypothesized that arginine could be a
beneficial treatment for pain related to sickle cell disease ... a
randomized, double blind placebo control clinical trial of 38 children with
sickle cell disease hospitalized for 56 episodes of pain. The research team
discovered a 54 percent reduction in the use of opioid pain medication and
significantly lower pain scores at hospital discharge in those treated with
arginine over those receiving placebo"
Amino Acid With Promising Anti-Diabetic Effects - Science Daily, 9/9/13
- "the amino acid is just as effective as several
well-established drugs for type 2 diabetics ... researchers subjected lean
and obese animal models to a so-called glucose tolerance test, which
measures the body's ability to remove glucose from the blood over time ...
both lean and fat laboratory mice benefit considerably from arginine
supplements. In fact, we improved glucose metabolism by as much as 40% in
both groups. We can also see that arginine increases the body's production
of glucagon-like peptide-1 (GLP-1), an intestinal hormone which plays an
important role in regulating appetite and glucose metabolism, and which is
therefore used in numerous drugs for treating type 2 diabetes"
Arginine and proline enriched diet may speed wound healing in diabetes -
Science Daily, 11/15/12 - "Researchers divided 18
rats into three groups that were either fed a standard diet, a high-protein
diet, or a high protein diet supplemented with arginine and proline
(ARG+PRO) ... Rats on both high protein diets had better nitrogen balance
than those on the standard diet. However, the wounds of the rats on the
ARG+PRO diet showed more new blood vessel growth on day 5. New blood vessel
growth is an essential part of wound healing as the blood vessels supply
nutrition and oxygen to growing tissue ... arginine and proline
supplementation could offer new hope for effective treatment in diabetic
patients with chronic wounds" - See
L-arginine products at Amazon.com and
L-proline products at Amazon.com.
- Effect of
Oral L-Arginine Supplementation on Blood Pressure - Medscape, 12/30/11 -
"This meta-analysis of randomized, double-blind,
placebo-controlled trials brought evidence that oral L-arginine
supplementation, compared with placebo, significantly lowered systolic BP by
5.39 mm Hg (95% CI −8.54 to −2.25) and diastolic BP by 2.66 mm Hg (95% CI
−3.77 to −1.54)"
Dietary Supplement May Help Prevent Preeclampsia - WebMD, 5/19/11 -
"women who ate daily food bars containing the amino
acid L-arginine and antioxidant vitamins during pregnancy had a much lower
incidence of preeclampsia than women who ate bars containing the antioxidant
vitamins alone or bars containing neither supplement ... far fewer of the
women in the L-arginine plus vitamin group developed preeclampsia (12.7%)
than women in the vitamin-alone (22.5%) group and no-supplement (30.2%)
- The Effects of
L-Arginine and Yohimbine on Sexual Arousal in Postmenopausal Women with FSAD
- University of Texas at Austin Dept. of Psychiatry
Research identifies the herbal supplements that are effective in treating
anxiety - Science Daily, 10/6/10 - "A systematic
review of research into the use of nutritional supplements for the treatment
of anxiety disorders has found strong evidence for the use of extracts of
passionflower or kava and combinations of L-lysine and L-arginine ... We
found mixed results -- while passionflower or kava and L-lysine and
L-arginine appeared to be effective, St John's Wort and magnesium
supplements were not"
Nutritional and herbal supplements for anxiety and anxiety-related
disorders: systematic review - Nutr J. 2010 Oct 7;9(1):42 -
"based on this systematic review, strong evidence
exists for the use of herbal supplements containing extracts of
passionflower or kava and combinations of L-lysine and L-arginine as
treatments for anxiety symptoms and disorders. Magnesium-containing
supplements and other herbal combinations may hold promise, but more
research is needed before these products can be recommended to patients. St.
John's wort monotherapy has insufficient evidence for use as an effective
Arginine Discovery Could Help Fight Human Obesity - Science Daily,
2/12/09 - "arginine, an amino acid, reduces fat mass
in diet-induced obese rats and could help fight human obesity ... dietary
arginine supplementation shifts nutrient partitioning to promote
skeletal-muscle gain ... The findings were published recently in the Journal
of Nutrition ... arginine supplementation for a 12-week period decreased the
body fat gains of low-fat and high-fat fed rats by 65 percent and 63
percent, respectively. The long-term arginine treatment did not have any
adverse effects on either group ... funded by the American Heart
Pine bark extract boost for blood flow and heart health - Nutra USA,
10/18/07 - "Acetylcholine stimulates the cells of
arteries to produce NO from L-arginine faster ... In turn, the NO causes the
muscle surrounding arteries to relax, which results in an increase of blood
vessel diameters. When subjects had taken Pycnogenol the relaxation of
arteries was increased by 42 per cent as compared to the group taking
placebo tablets" - See
Pycnogenol at Amazon.com
citicholine at Amazon.com.
Statins' Effect on Endothelial Function Enhanced by L-arginine in Some
Patients - Doctor's Guide, 6/11/07 -
"endothelium-dependent dilation (EDD) ...
simvastatin had no appreciable effect on EDD (6.2+/-1.2% vs. 6.1+/-0.9%) in
subjects with elevated ADMA. However, the addition of L-arginine to
simvastatin significantly improved EDD (9.8+/-1.5% vs. 5.3+/-0.8%; P <.01).
There were also significant improvements in EDD in response to L-arginine
Restoring Sexual Potency? - Dr. Weil, 5/4/06 -
"Arginine ... Ginkgo biloba ... Ashwaganda"
L-Arginine for Heart Attack - WebMD, 1/3/06 -
"All six deaths were among the 78 heart attack
patients who added L-arginine to their normal medical treatment regimen.
There were no deaths among the 75 heart attack patients who did not receive
The high five for hypertension - Functional Foods & Nutraceuticals,
12/04 - "Co-enzyme Q10 ...
Omega-3 fatty acids ...
Garlic ... L-arginine ... Calcium"
- OTC Cream
Improves Blood Flow in Feet - WebMD, 1/8/04 -
"arginine does increase blood flow, but it is not yet clear if this
translates into fewer foot ulcers or better healing of ulcers"
Nitric Oxide Now -- Ask Me How - WashingtonPost.com, 10/6/03 -
"In the arteries, the innermost layer of cells releases
nitric oxide to signal smooth muscle cells to dilate (increase the
diameter of) the arteries. This allows blood to flow more freely,
particularly during exercise ... By the 1990s, many scientists saw nitric
oxide as the next great weapon for treating heart disease, impotence and
even bacterial infections ... Niteworks has L-arginine and also
L-citrulline, which recycles spent L-arginine by resupplying it with
atoms it lost producing nitric oxide ... "Ninety dollars a month? That's
obscene," Murad said. "You can probably get [vitamin] C and E for pennies a
day. You can probably get arginine for about a dollar a day"" - See
L-citrulline at Amazon.com.
- Arginine Supplements
May Help Treat Pulmonary Hypertension in Sickle Cell
- Medscape, 6/30/03
Blood Vessels From Stress - WebMD, 1/15/03 -
"vitamins can improve blood flow and prevent the long-term development of
atherosclerosis -- or
hardening of the arteries -- when
given in combination with an amino acid known as L-arginine ... antioxidants
might work together with L-arginine to prevent
inflammation in the branch areas of blood vessels ... although
antioxidants may not reverse or repair pre-existing damage within blood
vessels, they may slow the long-term progression of atherosclerosis"
L-Arginine Minimises Stroke Damage in Mitochondrial Encephalomyopathy with
Lactic Acidosis and Stroke-like Episodes - Doctor's Guide, 10/16/02
- Natural Remedy for
Erectile Dysfunction - New Hope Natural Media, 9/5/02 -
"received three separate treatments for two weeks each, in random order: (1)
3.25 grams of arginine plus 6 mg of
yohimbine alone and (3) placebo ... Combination treatment was considered
successful by 40% of the participants, compared with 28.9% with yohimbine
alone and 17.8% with placebo ... Arginine is available in health food stores
without a prescription, but yohimbine can be obtained only with a doctor's
prescription. Although the herb yohimbe is sold in health food stores, it
contains much less yohimbine than the amount used in the new study" -
l-arginine at Amazon.com.
Yohimbine Plus L-Arginine Potential Therapy For Mild To Moderate Erectile
Dysfunction - Doctor's Guide, 7/31/02 -
"randomly assigned 45 men with
erectile dysfunction to treatment with 6 mg of
L-arginine glutamate combined with 6 mg of
hydrochloride, to 6 mg of yohimbine hydrochloride alone, or to placebo ...
They took the drugs orally one to two hours before intended sexual
intercourse ... Changes in this score [Index of Erectile Function (IIEF)]
were significantly greater among patients taking yohimbine plus L-arginine
compared to those taking placebo" - Note: That "6 mg of L-arginine
glutamate" has to be a misprint. It probably should have been 6 grams as in
U. of Texas study on
Arginine and Fish Oil May Help Cancer Patients Undergoing Chemotherapy -
Life Extension Magazine, 7/02
L-Arginine Application Speeds Healing of Anal Fissure
- Doctor's Guide, 6/10/02
- Concepts and
Controversies in Nutrition, Immune-Enhancing Formulas
- Medscape, 3/21/02 -
"Immune-enhancing formulas (IEFs), also known as
immune-modulating formulas, include arginine,
glutamine, nucleic acids, and omega-3
The Wizard is Oz - Life Extension Magazine, 11/01 -
"Best-selling author and nutritional guru to the
rich and famous, Oz Garcia is singing the praises of the Life Extension
Foundation and its products in his newest book,
Healthy High Tech Body, published in September 2001 ... Supplements at
the top of Garcia's list of recommendations ...
DHA ... NADH ...
Alpah Lipoic Acid
... Acetyl-L-Carnitine ... An expanded list of his
recommendations includes lycopene,
gamma tocopherol, vinpocetine, SAMe,
folic acid, carnosine,
glutathione, DMAE, Huperzine A,
arginine pyroglutamate, IP-6,
bioflavonoid formulas and
grape skin/seed extracts"
Nutritional Supplement Boosts Immune Function In Surgery Patients
- Intelihealth, 9/13/01 - "A new study published in
the journal Lancet suggests that people who are at high risk of infection
after heart surgery may benefit from taking a nutritional supplement
containing L-arginine and omega-3 fatty acids"
- Quinopril and L-Arginine
Improves Endothelial Function In Hypertensive Patients
- Doctor's Guide, 6/21/01
Study: Supplement Can Help Take the 'Dys' Out of Female Sexual Dysfunction,
Researchers Promote Idea of 'Sexual Wellness' - WebMD, 6/5/01 -
"ArginMax -- a dietary
cocktail consisting of ginseng, ginkgo, B vitamins, calcium, folic acid, and
other vitamins and minerals -- is being heralded as one component of a
lifestyle that improves sexual performance and helps prevent problems
associated with intimacy"
Want a love potion? What to know before you try - CNN, 6/15/00 -
"a study of 21 men with "mild to moderate" impotence
taking a supplement called
ArginMax (3,000 milligrams per day) found big
improvements in erection and sexual satisfaction."
Immune-Enhancing Therapy Shortens Hospital Stays By Three Days -
Doctor's Guide, 12/23/99 - "The trials, conducted at
medical centers in the U.S. and Europe, compared patients receiving standard
enteral nutrition with patients who received commercially available
immune-enhancing therapies containing arginine and
glutamine (naturally occurring amino acids), nucleotides (found in
yeast), and omega-3 fatty acids (found in
fish oil) ... Our study shows that immunonutrition can make a significant
contribution to reducing the number of infections and length of hospital
stay in critically ill patients"
Women and Sex Drive - Life Enhancement Magazine, 12/99 -
"Because the amino acid arginine is the precursor to
nitric oxide, its ingestion and concomitant elevation in the serum
accomplish much the same goal as Viagra, as several studies have borne out"
Arginine for Muscles, Memory, Sex and More - Life Enhancement Magazine,
12/99 - "Arginine is the primary source of the
nitrogen that results in production of the important biomolecule
nitric oxide (NO) ... NO helps defend the
body against invading bacteria2 and parasites. In the brain, where it is
formed in nerve cells, it diffuses in all directions, activating all cells
in the vicinity, thus modulating many functions, including behavior and
gastrointestinal transit flow. The release of NO is absolutely essential for
motor learning in the cerebellum (coordination), and it also appears to be
necessary for long-term potentiation in the brain, which is the mechanism
involved in long-term memory. NO is now also thought to be important in our
olfactory (smelling) sensations and our capacity to identify different
scents ... Free arginine has been shown to help prevent a destructive
process known as
cross-linking, which is associated with accelerated aging. Excessive
cross-linking reactions inevitably damage the kidneys, necessitating
dialysis in advanced age"
Study finds new therapy for impotence - CNN, 10/27/99 -
"Nitric oxide is the messenger, if you will, the
signaling molecule, and without that signal you can't get that signal from
the brain to the penis for the erectile process ... An amino acid call
L-argenine produces nitric oxide in the body"
Be All That You Can Be - Life Enhancement Magazine, 7/99 -
"the erections were harder and longer-lasting and so
forth when they were using L-arginine. The two studies I have in mind used
2,800 mg and 2,500 mg of arginine, respectively"
Viagra anniversary sees herbal competitors by the dozens - CNN, 3/26/99
- "Since the main problem in impotence is actually a
problem with circulation of the blood vessels in the penis, l-arginine holds
great promise for men with physical impotence"
Enhancement - Life Enhancement Magazine, 3/97 -
"According to numerous anecdotal reports from highly
satisfied arginine users since the early 1980s, dietary L-arginine can give
men erections that are bigger, harder, more frequent, and longer lasting.
Some men also report that L-arginine gives them greater endurance. In women,
L-arginine has been reported to increase the intensity of sensation during
sex. One highly athletic 30-something woman tells about the time she told
her doctor about her L-arginine use. "My doctor almost fell off his chair
when I told him how many times a night I do it - six-times," she said. "He's
definitely taking arginine now, too.""
Is More Efficient than Arginine in Increasing Systemic Arginine Availability in
Mice - J Nutr. 2017 Feb 8 - "Arginine is considered
to be an essential amino acid in various (patho)physiologic conditions of high
demand. However, dietary arginine supplementation suffers from various
drawbacks, including extensive first-pass extraction. Citrulline supplementation
may be a better alternative than arginine, because its only fate in vivo is
conversion into arginine ... Citrulline supplementation is more efficient at
increasing arginine availability than is arginine supplementation itself in
mice" - See BulkSupplements Pure
L-Citrulline DL-Malate 2:1 Powder at Amazon.com and
BulkSupplements Pure L-Arginine HCL Powder at
The effect of l-arginine
supplementation on body composition and performance in male athletes: a
double-blinded randomized clinical trial - Eur J Clin Nutr. 2017 Jan 25 -
"Athletes received daily either 2 g per day l-arginine
supplement or the same amount of placebo (maltodextrin) for 45 days ... Sport
performance (VO2 max) significantly increased in l-arginine supplementation
group (4.12±6.07) compared with placebo group (1.23±3.36) (P=0.03). This
increase remained significant even after adjustment of baseline values, physical
activity and usual dietary intake of subjects throughout the study. No
significant effect of l-arginine supplementation was found on weight, BMI, BFM
The effects on plasma
L-arginine levels of combined oral L-citrulline and L-arginine supplementation
in healthy males - Biosci Biotechnol Biochem. 2017 Feb;81(2):372-375 -
"Oral l-citrulline plus l-arginine supplementation more
efficiently increased plasma l-arginine levels than 2 g of l-citrulline or
l-arginine, suggesting that oral l-citrulline and l-arginine increase plasma
l-arginine levels more effectively in humans when combined" - [Nutra
USA] - See
BulkSupplements Pure L-Arginine HCL Powder
at Amazon.com and
BulkSupplements Pure L-Citrulline Powder at
Double-Blind Studies to Evaluate the Cognitive Effects of Inositol-Stabilized
Arginine Silicate in Healthy Physically Active Adults - Nutrients. 2016 Nov
18;8(11) - "Inositol-stabilized arginine silicate (ASI;
Nitrosigine®) has been validated to increase levels of arginine, silicon and
nitric oxide production. To evaluate potential enhancement of mental focus and
clarity, ASI (1500 mg/day) was tested in two double-blind placebo-controlled
crossover (DBPC-X) studies using the Trail Making Test (TMT, Parts A and B) ...
These findings show that ASI significantly improved the ability to perform
complex cognitive tests requiring mental flexibility, processing speed and
executive functioning" - See Nitrosigine®
L-citrulline supplementation enhances cycling time trial performance in healthy
trained men: Double-blind randomized placebo-controlled 2-way crossover study
- Journal of the International Society of Sports Nutrition 201613:6 -
"L-Citrulline supplementation significantly increased
plasma L-arginine levels and reduced completion time by 1.5 % (p < 0.05)
compared with placebo. Moreover, L-citrulline significantly improved subjective
feelings of muscle fatigue and concentration immediately after exercise"
promotes gut hormone release and reduces food intake in rodents - Diabetes
Obes Metab. 2016 Feb 11 - "L-Arg reduced food intake and
stimulated gut hormone release in rodents" - See
L-arginine products at Amazon.com.
behaviour after arginine or citrulline administration in older subjects - Br
J Nutr. 2015 Dec 1:1-6 - "Arginine (ARG) and its
precursor citrulline (CIT) are popular dietary supplements, especially for the
elderly. However, age-related reductions in lean body mass and alterations in
organ functions could change their bioavailability ... In conclusion, a single
CIT administration in the elderly is safe and well tolerated, and CIT proves to
be a better in vivo ARG precursor than ARG itself in healthy elderly subjects"
citrulline at Amazon.com.
The Role of
CD36 in the Effect of Arginine in Atherosclerotic Rats - Med Sci Monit. 2015
May 24 - "The addition of arginine has a significant
effect on reducing rat atherosclerosis development, which may be attributed to
both the down-regulation of CD36 expression in rat aortic endothelial and blood
mononuclear cells and the NO pathway"
But Not l-Arginine, Prevents Diabetes Mellitus-Induced Glomerular
Hyperfiltration and Proteinuria in Rat - Hypertension. 2014 May 27 -
"l-citrulline administered to diabetic rats increases
plasma l-arginine concentration, which prevents the diabetes mellitus-induced
glomerular hyperfiltration, filtration fraction, and proteinuria, possibly by a
vascular effect" - See
l-citrulline at Amazon.com.
arginine-enriched enteral formulas in the reduction of surgical complications in
head and neck cancer: A systematic review and meta-analysis - Clin Nutr.
2014 May 4 - "Arginine improves healing and modulates
inflammation and the immune response. A systematic review and meta-analysis were
conducted to assess whether arginine-enriched enteral formulas reduce
complications (fistulas, wound infections, other infections) and hospital length
of stay (LoS) in patients undergoing surgery for head and neck cancer ... The
administration of arginine-enriched enteral nutrition led to a significant
reduction in fistulas and hospital stay in patients undergoing surgery for head
and neck cancer"
Supplementation Prevents Increases in Intestinal Permeability and Bacterial
Translocation in Male Swiss Mice Subjected to Physical Exercise under
Environmental Heat Stress - J Nutr. 2013 Nov 20 -
"core body temperature (Tcore) ... Our results indicate that dietary l-arginine
supplementation preserves the integrity of the intestinal epithelium during
exercise under heat stress, acting through mechanisms that are independent of
watermelon supplementation on arterial stiffness and wave reflection amplitude
in postmenopausal women - Menopause. 2013 May;20(5):573-7 -
"In a randomized cross-over study, 12 postmenopausal
women (mean [SE] age, 57  y; mean [SE] body mass index, 38.1 [2.1] kg/m; mean
[SE] SBP, 153  mm Hg) were assigned to watermelon supplementation
(L-citrulline/L-arginine 6 g/d) or placebo supplementation for 6 weeks ... baPWV
(-1.2 [0.3] m/s, P < 0.001), aortic SBP (-10  mm Hg, P < 0.01), and aortic
diastolic blood pressure (-7  mm Hg, P < 0.001) decreased after watermelon
supplementation compared with placebo ... Watermelon supplementation reduces
arterial stiffness and aortic SBP by reducing pressure wave reflection amplitude
in obese postmenopausal women with hypertension" - Note: A -10 on the
systolic is about what you'd get with prescription medications. - See
Stimulin at Amazon.com
(1,875 mg of L-citrulline) and
L-arginine products at Amazon.com.
of brown adipose tissue development and white fat reduction by L-arginine -
Curr Opin Clin Nutr Metab Care. 2012 Nov;15(6):529-38 -
"Brown adipose tissue (BAT), which is present in humans, plays an important role
in oxidation of fatty acids and glucose ... L-arginine increases mammalian BAT
growth and development via mechanisms involving gene expression, nitric oxide
signaling, and protein synthesis. This enhances the oxidation of energy
substrates and, thus, reduces white fat accretion in the body. L-arginine holds
great promise in preventing and treating obesity in humans"
enhances glucose and lipid metabolism in rat L6 myotubes via the NO/ c-GMP
pathway - Metabolism. 2012 Aug 10 - "The amino acid
Arginine (Arg) is the main biological precursor of nitric oxide (NO) and has
been described to improve insulin sensitivity in diabetes and obesity. We
investigated the molecular mechanisms involved in the long-term effects of Arg
on glucose and lipid metabolism ... We provide evidence that Arg improves
glucose and lipid metabolism in skeletal muscle, in parallel with increased
phosphorylation of Akt and AMPK-α. These effects were mediated by the NO/c-GMP
pathway. Thus, arginine treatment enhances signal transduction and has a
beneficial effect of metabolism in skeletal muscle through direct activation of
Akt and AMPK pathways"
administered L-arginine and glycine are highly effective against acid reflux
esophagitis in rats - Med Sci Monit. 2011 Dec 22;18(1):BR9-15 -
"L-alanine and L-glutamine exert a deleterious effect on
the esophagitis, while L-arginine and glycine are highly protective" -
L-arginine products at Amazon.com
L-glycine at Amazon.com.
oral l-arginine supplementation on blood pressure: A meta-analysis of
randomized, double-blind, placebo-controlled trials - Am Heart J. 2011
Dec;162(6):959-65 - "We included 11 randomized,
double-blind, placebo-controlled trials involving 387 participants with oral
l-arginine intervention ranging from 4 to 24 g/d. Compared with placebo,
l-arginine intervention significantly lowered systolic BP by 5.39 mm Hg (95% CI
-8.54 to -2.25, P = .001) and diastolic BP by 2.66 mm Hg (95% CI -3.77 to -1.54,
P < .001). Sensitivity analyses restricted to trials with a duration of 4 weeks
or longer and to trials in which participants did not use antihypertensive
medications yielded similar results. Meta-regression analysis suggested an
inverse, though insignificant (P = .13), relation between baseline systolic BP
and net change in systolic BP"
Propionyl-L-carnitine, L-arginine and niacin in sexual medicine: a nutraceutical
approach for erectile dysfunction - Andrologia. 2011 Oct 4 -
"In a group of 54 unselected men (35-75 years), consecutively presenting to our
ED clinic and naive to other ED treatments, we carried out a single-blind,
one-arm study to evaluate the effects of a 3-month supplementation with
propionyl-L-carnitine, L-arginine and niacin on their sexual performance ...
Analyses on GAQs revealed that treatment improved erections in 40% of cases,
with a partial response occurring in up to 77% of enrolled subjects. These
preliminary findings indicate that the favourable cardiovascular effects of
nutraceuticals might also reflect on male sexual function with possible
implication in the treatment and prevention of ED. This study documents a
considerable patients' interest toward nutritional supplementation - as
first-line or adjunctive treatment to PDE5 inhibitors - that goes beyond the
measurable increment in penile rigidity" - See
propionyl-l-carnitine products at Amazon.com,
niacin at Amazon.com
L-arginine products at Amazon.com.
Assessment of a Supplement of Pycnogenol® and l-arginine in Japanese Patients
with Mild to Moderate Erectile Dysfunction - Phytother Res. 2011 May 27 -
"Subjects were instructed to take a supplement
(Pycnogenol® 60 mg/day, l-arginine 690 mg/day and aspartic acid 552 mg/day) or
an identical placebo for 8 weeks, and the results were assessed using the
five-item erectile domain (IIEF-5) of the International Index of Erectile
Function. Additionally, blood biochemistry, urinalysis and salivary testosterone
were measured. Eight weeks of supplement intake improved the total score of the
IIEF-5. In particular, a marked improvement was observed in 'hardness of
erection' and 'satisfaction with sexual intercourse'. A decrease in blood
pressure, aspartate transaminase and γ-glutamyl transpeptidase (γ-GTP), and a
slight increase in salivary testosterone were observed in the supplement group.
No adverse reactions were observed during the study period. In conclusion,
Pycnogenol® in combination with l-arginine as a dietary supplement is effective
and safe in Japanese patients with mild to moderate erectile dysfunction"
Pycnogenol at Amazon.com,
L-arginine products at Amazon.com
l-aspartic acid at Amazon.com.
L-citrulline supplementation improves erection hardness in men with mild
erectile dysfunction - Urology. 2011 Jan;77(1):119-22 -
"L-arginine supplementation improves nitric
oxide-mediated vasodilation and endothelial function; however, oral
administration has been hampered by extensive presystemic metabolism. In
contrast, L-citrulline escapes presystemic metabolism and is converted to
L-arginine, thus setting the rationale for oral L-citrulline supplementation as
a donor for the L-arginine/nitric oxide pathway of penile erection ... A total
of 24 patients, mean age 56.5 +/- 9.8 years, were entered and concluded the
study without adverse events. The improvement in the erection hardness score
from 3 (mild ED) to 4 (normal erectile function) occurred in 2 (8.3%) of the 24
men when taking placebo and 12 (50%) of the 24 men when taking L-citrulline (P <
.01). The mean number of intercourses per month increased from 1.37 +/- 0.93 at
baseline to 1.53 +/- 1.00 at the end of the placebo phase (P = .57) and 2.3 +/-
1.37 at the end of the treatment phase (P < .01). All patients reporting an
erection hardness score improvement from 3 to 4 reported being very satisfied"
citrulline malate at Amazon.com.
Perioperative arginine-supplemented nutrition in malnourished patients with head
and neck cancer improves long-term survival - Am J Clin Nutr. 2010 Sep 29 -
"Plasma arginine concentrations are lower in patients
with cancer, which indicates that arginine metabolism may be disturbed in these
patients. Arginine supplementation has been associated with positive effects on
antitumor mechanisms and has been shown to reduce tumor growth and to prolong
survival. Furthermore, the prognosis of patients with head and neck cancer
remains disappointing. Insufficient intake frequently leads to malnutrition,
which contributes to high morbidity and mortality rates ... The group receiving
arginine-enriched nutrition had a significantly better overall survival (P =
0.019) and better disease-specific survival (P = 0.022). Furthermore, the
arginine-supplemented group had a significantly better locoregional
recurrence-free survival (P = 0.027). No significant difference in the
occurrence of distant metastases or occurrence of a second primary tumor was
observed between the groups"
Long-Term L-Arginine Supplementation on Arterial Compliance and Metabolic
Parameters in Patients with Multiple Cardiovascular risk Factors: Randomized,
Placebo-Controlled Study - J Cardiovasc Pharmacol. 2010 Jun 7 -
"large artery elasticity index (LAEI) ... Although large
artery elasticity index (LAEI) did not differ significantly between the groups
at baseline (10.64.3 vs.11.64.5 ml/mm HgX100, p=0.346), at the end of the study
LAEI was significantly greater in patients treated with L-arginine than in the
placebo group (12.73.4 vs. 8.02.8 ml/mm HgX10, p<0.0001). Systemic vascular
resistance was significantly lower in patients treated with L-arginine than in
the placebo group after 6 months. Small artery elasticity index (SAEI) did not
differ significantly between the groups at baseline or at the end of the study.
Serum aldosterone decreased significantly in Group 1 from 10.76.3 to 8.45.0
ng/ml (p=0.008), but did not change in the placebo group. CONCLUSION::
L-arginine supplementation improves LAEI in patients with multiple
cardiovascular risk factors. This improvement was associated with a decrease in
systolic blood pressure, peripheral vascular resistance as well as a decrease in
aldosterone levels. The results suggest that long term L-arginine
supplementation has beneficial vascular effects in pathologic disease states
associated with endothelial dysfunction"
effects of resveratrol in mice with indomethacin-induced gastric ulcers are
reversed by l-arginine - Br J Pharmacol. 2010 Jan 8 -
"Although resveratrol is currently being evaluated in
pre-clinical studies as a potential cancer chemopreventive agent and
cardiovascular stress-releasing compound, treatment with resveratrol severely
delays healing of pre-existing gastric ulcers. Resveratrol treatment can also
induce endothelial NOS (eNOS) expression ... Resveratrol significantly
aggravated damage from indomethacin-induced gastric ulcers, and delayed healing,
as shown by increased DS and MPO activity. The mRNA for cyclooxygenase (COX)-1,
but not that for COX-2, was inhibited by resveratrol treatment, with reduced
synthesis of PGE(2) by gastric tissue. However, resveratrol treatment induced
eNOS gene expression and shifted the eNOS/iNOS balance. l-Arginine given before
resveratrol in mice with indomethacin-induced ulcers significantly increased
tissue NO synthesis and improved ulcer healing" - See
L-arginine products at Amazon.com.
of nitric oxide production in health and disease Curr Opin Clin Nutr Metab
Care. 2009 Oct 16 - "The role of the cofactor
tetrahydrobiopterin in nitric oxide production and its relation with arginine
availability is indicated as an important explanation for the arginine paradox.
This offers potential for nitric oxide regulation by dietary factors such as
arginine or its precursors and vitamin C. Because diets with a high saturated
fat content induce high plasma fatty acid levels, endothelial nitric oxide
production is often impaired due to a reduction in nitric oxide synthase 3
phosphorylation. Increasing the arginine availability by arginine therapy or
arginase inhibition was, therefore, proposed as a potential therapy to treat
hypertension. Recent studies in septic patients and transgenic mice models found
that inadequate de-novo arginine production from citrulline reduces nitric oxide
production. Citrulline supplementation may, therefore, be a novel therapeutic
approach in conditions of arginine deficiency" - See
L-arginine products at Amazon.com
l-citrulline at Amazon.com.
Supplementation of L-Arginine and Conjugated Linoleic Acid Reduces
Retroperitoneal Fat Mass and Increases Lean Body Mass in Rats - J Nutr. 2009
May 13 - "We conclude that CLA and arginine modulated
adipose tissue metabolism by separate, but not additive, effects. Also, CLA and
arginine may have depressed muscle protein turnover" - See
conjugated linoleic acid at Amazon.com
l-arginine products at Amazon.com.
L-Arginine Supplementation Reduces White Fat Gain and Enhances Skeletal Muscle
and Brown Fat Masses in Diet-Induced Obese Rats - J Nutr. 2008 Dec 23 -
"l-arginine-HCl ... Despite similar energy intake,
absolute weights of white fat pads increased by 98% in control rats over a 12-wk
period but only by 35% in arginine-supplemented rats. The arginine treatment
reduced the relative weights of white fat pads by 30% and enhanced those of
soleus muscle by 13%, extensor digitorum longus muscle by 11%, and brown fat by
34% compared with control rats ... arginine treatment resulted in lower serum
concentrations of leptin, glucose, triglycerides, urea, glutamine, and
branched-chain amino acids, higher serum concentrations of nitric-oxide
metabolites, and improvement in glucose tolerance. Thus, dietary arginine
supplementation shifts nutrient partitioning to promote muscle over fat gain and
may provide a useful treatment for improving the metabolic profile and reducing
body white fat in diet-induced obese rats" - See
arginine products at Amazon.com.
Addition of 2.5g l-arginine in a fatty meal prevents the lipemia-induced
endothelial dysfunction in healthy volunteers - Atherosclerosis. 2008
Nov 6 - "2.5g l-arginine, but not phenyalanine or
leucine, is able to prevent the lipemic dysfunction of the endothelium"
Kidney damage after renal ablation is worsened in endothelial nitric oxide
synthase (-/-) mice and improved by combined administration of L-arginine
and antioxidants - Nephrology (Carlton). 2008 Jun;13(3):218-27 -
"A combination of L-arginine and antioxidant
ameliorated renal damage"
Long Term N-Acetylcysteine and L-Arginine Administration Reduces Endothelial
Activation and Systolic Blood Pressure in Hypertensive Patients with Type 2
Diabetes Mellitus - Diabetes Care. 2008 Feb 11 -
"The NAC+ARG administration seems to be a potential well-tolerated
antiatherogenic therapy since it improves the endothelial function in
hypertensive patients with type 2 diabetes by improving NO bioavailability
via reduction of the oxidative stress and increase of NO production. Our
study's results give prominence to its potential use in the primary and
secondary cardiovascular prevention in these patients"
Pharmacokinetics of arginine and related amino acids - J Nutr. 2007
Biomarkers of arginine and lysine excess - J Nutr. 2007
Jun;137(6):1662S-8S - "Arginine supplementation is
used in several disease states. In arginine-deficient states,
supplementation is a logical choice of therapy. However, the definition of
an arginine-deficient state is complex. For example, plasma arginine levels
could be within normal range but intracellular arginine levels could be
reduced because of membrane transport problems. Lysine competes with
arginine for transport into the cell. In these situations, arginine
supplementation of higher than required levels is proposed. Arginine has
several important functions in metabolism as it is a precursor of
metabolically active components such as nitric oxide (NO), ornithine,
creatine, and polyamines"
Oral treatment with L-lysine and L-arginine reduces anxiety and basal
cortisol levels in healthy humans - Biomed Res. 2007 Apr;28(2):85-90 -
"the treatment with L-lysine and L-arginine
decreased the basal levels of salivary cortisol and chromogranin-A (a
salivary marker of the sympatho-adrenal system) in male subjects"
l-Arginine, the substrate for NO synthesis: An alternative treatment for
premature atherosclerosis? - Int J Cardiol. 2006 Jul 20 -
"l-arginine administration may be useful in patients
with premature atherosclerosis"
Treatment with supplementary arginine, vitamin C and zinc in patients with
pressure ulcers: A randomised controlled trial
- Clin Nutr. 2005 Nov 14;24(6):979-987 - "In this
small set of patients, supplementary arginine, vitamin C and zinc
significantly improved the rate of pressure ulcer healing"
Effects of vitamin C on intracoronary L-arginine dependent coronary
vasodilatation in patients with stable angina - Heart. 2005
Oct;91(10):1319-23 - "L-arginine dependent coronary
segment vasodilatation was augmented by the antioxidant vitamin C in
patients with coronary artery disease. Thus, vitamin C may have beneficial
effects on nitric oxide bioavailability induced by L-arginine"
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