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Home > Anti-aging Research > Bilberry (Vaccinium myrtillus).
Bilberry (Vaccinium myrtillus)
Specific Recommendations:
News & Research:
- Bilberry - Compiled by Chad Bradshaw, Pharm.D
- Bilberry - The Natural Pharmacist
-
Bilberry-pine bark mix shows eye health benefits - Nutra USA, 5/24/10 -
"One group received daily Mirtogenol supplements (40 mg
Pycnogenol, 80 mg Mirtoselect), one group received Latanoprost eye drops, and
the third group received a combination of both ... After 24 weeks of
intervention, the researchers noted a reduction of blood pressure in the eye
from an average of 38.1 to 29.0 mmHg in the Mirtogenol group, from 37.7 to 27.2
mmHg in the Latanoprost group, and from 38.0 to 23.0 mmHg in the combined group.
Normal eye pressure is reported to range from 10 to 21 mmHg"
-
Bilberry extract shows anti-diabetes benefits: Mouse study - Nutra USA,
2/17/10 - "At the end of the study, the results showed that consumption of the
bilberry extract was associated with lower blood glucose levels and increased
insulin sensitivity. This was linked to an activation of a protein which
stimulates lipid breakdown in liver and muscle and modulates insulin secretion
by the pancreas called AMP-activated protein kinase (AMPK)" - [Abstract]
-
Dietary
Anthocyanin-Rich Bilberry Extract Ameliorates Hyperglycemia and Insulin
Sensitivity via Activation of AMP-Activated Protein Kinase in Diabetic Mice
- J Nutr. 2010 Jan 20 - "Blueberries or bilberries
contain large amounts of anthocyanins, making them one of the richest
sources of dietary anthocyanin ... bilberry extract (BBE) ... Dietary BBE
significantly reduced the blood glucose concentration and enhanced insulin
sensitivity ... These findings provide a biochemical basis for the use of
bilberry fruits and have important implications for the prevention and
treatment of type 2 diabetes via activation of AMPK"
-
Bilberries may prevent artery hardening, boost heart health - Nutra USA,
11/9/09
-
Bilberry extract may ease the damages of stress: study - Nutra USA,
10/28/08 - "Mice supplemented with an anthocyanin-rich
bilberry extract (Mirtoselect, Indena) at doses of 50, 100, and 200
milligrams per kilograms per day experienced lower ALT levels than
non-supplemented restrained animals (17.23 versus 107.68 units per litre,
respectively)"
-
Bilberry and pine bark combo wards off glaucoma: study - Nutra USA,
7/24/08 - "intra-ocular hypertension (IOP) ... The
bilberry and pine bark product was Mirtogenol, a combination of Indena's
Mirtoselect standardised bilberry extract and Horphag's Pycnogenol pine bark
extract ... IOP was also seen to be lowered in 19 of the 20 intervention
patients, from an average of 25.2mmHg to 22.0mmHG. Only one of the control
patients saw a drop in IOP" - [Abstract]
- See
bilberry products at iHerb
and
pine bark/Pycnogenol products at iHerb.
-
Effects of Mirtogenol on ocular blood flow and intraocular hypertension in
asymptomatic subjects - Mol Vis. 2008 Jul 10;14:1288-92 -
"intraocular pressure (IOP) ... After two months of
supplementation with Mirtogenol, the mean IOP decreased from a baseline of
25.2 mmHg to 22.2 mmHg. After three months of treatment with Mirtogenol, the
IOP was significantly lowered compared to that of untreated controls
(p<0.05) to 22.0 mmHg" - [Nutra
USA] - See
bilberry products at iHerb
and
pine bark/Pycnogenol products at iHerb.
-
Four New Studies Strongly Suggest That Components From Three Types [elderberry, chokeberry and bilberry] Of Red Berry Fruits Help Arteries - Intelihealth, 4/22/02 -
"Extracts from chokeberry and bilberry, but not elderberry, produce a direct dose-dependent relaxation of porcine coronary arteries, with chokeberry extract being the most potent. This relaxation was totally dependent on the vascular endothelium because the
extracts did not significantly contract or relax arteries in which the endothelium was removed"
- Got Anthocyanins? - Nutrition Science News, 12/01
- Phytochemicals: The Ties That Bind - Nutrition Science News, 7/01 -
"Bilberry has become popular for its ability to help correct vision
disorders associated with retina degeneration, including macular degeneration, retinitis pigmentosa, poor night vision, and diabetic retinopathy. It also improves or prevents glaucoma and cataracts"
- Second Sight - Nutrition Science News, 4/99Protective
Effects of Bilberry (Vaccinium myrtillus L.) Extract on Restraint
Stress-Induced Liver Damage in Mice - J Agric Food Chem. 2008
Aug 9 - "Bilberry extract (containing 42.04%
anthocyanins) was oral administrated to mice at 50, 100, and 200
mg/(kg.day) for five days, which remarkably decreased plasma ALT
level to 17.23 +/- 2.49 U/L at the dose of 200 mg/(kg.day) and thus
alleviated stress-induced liver damage. In addition, bilberry
extracts increased glutathione (GSH) and vitamin C levels and
significantly decreased MDA and nitric oxide (NO) levels in the
liver tissues. These results suggest that bilberry extract plays an
important role in protecting against restraint stress-induced liver
damage by both scavenging free radicals activity and lipid
peroxidation inhibitory effect. This study showed the beneficial
health effects of bilberry extract through its antioxidative action"
-
Protective Effects of Bilberry (Vaccinium myrtillus L.) Extract on
KBrO3-Induced Kidney Damage in Mice - J Agric Food Chem. 2007
Dec 20 - "bilberry extract reduced the
degree of oxidative stress and kidney damage induced by KBrO 3.
These findings demonstrate that the protective effect of bilberry
extract is attributed to its free radical scavenging activity and
lipid peroxidation inhibitory effect"
Abstracts:
-
Bilberry
anthocyanin-rich extract alters expression of genes related to atherosclerosis
development in aorta of apo E-deficient mice - Nutr Metab Cardiovasc Dis.
2010 Jul 31 - "bilberry anthocyanin-rich extract (BE) ... BE supplementation
significantly improved hypercholesterolemia whereas the plasmatic antioxidant
status remained unchanged. Nutrigenomic analysis identified 1261 genes which
expression was modulated by BE in the aorta. Bioinformatic analysis revealed
that these genes are implicated in different cellular processes such as
oxidative stress, inflammation, transendothelial migration and angiogenesis,
processes associated with atherosclerosis development/protection. Some of the
most significantly down-regulated genes included genes coding for AOX1, CYP2E1
or TXNIP implicated in the regulation of oxidative stress, JAM-A coding for
adhesion molecules or VEGFR2 implicate in regulation of angiogenesis. Other
genes were up-regulated, such as CRB3, CLDN14 or CDH4 potentially associated
with increased cell-cell adhesion and decreased paracellular permeability. These
results provide a global integrated view of the mechanisms involved in the
preventive action of bilberry anthocyanin-rich extract against atherosclerosis"
-
Dietary
Anthocyanin-Rich Bilberry Extract Ameliorates Hyperglycemia and Insulin
Sensitivity via Activation of AMP-Activated Protein Kinase in Diabetic Mice
- J Nutr. 2010 Jan 20 - "We found that dietary BBE
ameliorates hyperglycemia and insulin sensitivity via activation of
AMP-activated protein kinase (AMPK). Dietary BBE significantly reduced the blood
glucose concentration and enhanced insulin sensitivity. AMPK was activated in
white adipose tissue (WAT), skeletal muscle, and the liver of diabetic mice fed
BBE. This activation was accompanied by upregulation of glucose transporter 4 in
WAT and skeletal muscle and suppression of glucose production and lipid content
in the liver. At the same time, acetyl-CoA carboxylase was inactivated and
PPARalpha, acyl-CoA oxidase, and carnitine palmitoyltransferase-1A were
upregulated in the liver. These changes resulted in improved hyperglycemia and
insulin sensitivity in type 2 diabetes. These findings provide a biochemical
basis for the use of bilberry fruits and have important implications for the
prevention and treatment of type 2 diabetes via activation of AMPK"
-
Anthocyanin supplementation improves serum LDL- and HDL-cholesterol
concentrations associated with the inhibition of cholesteryl ester transfer
protein in dyslipidemic subjects - Am J Clin Nutr. 2009 Jul 29 -
"Anthocyanin consumption increased HDL-cholesterol
concentrations (13.7% and 2.8% in the anthocyanin and placebo groups,
respectively; P < 0.001) and decreased LDL-cholesterol concentrations (13.6%
and -0.6% in the anthocyanin and placebo groups, respectively; P < 0.001).
The cellular cholesterol efflux to serum increased more in the anthocyanin
group than in the placebo group (20.0% and 0.2%, respectively; P < 0.001).
Anthocyanin supplementation decreased the mass and activity of plasma
cholesteryl ester transfer protein (CETP) (10.4% and 6.3% in the anthocyanin
group and -3.5% and 1.1% in the placebo group, respectively; P < 0.001)"
- See
blueberry extracts at iHerb
and
bilberry products at iHerb.
Where to purchase bilberry separately:
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