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Home > Anti-aging Research > Antioxidants.

Antioxidants

Specific Recommendations:

• Anti-Oxidants at iHerb
• SODzyme products at iHerb

CME:

General Information:

• Antioxidants and Free Radicals - Vitacost Health Library
• Multiple Vitamin-Mineral Supplements - Vitacost Health Library
• Vitamin and Mineral Supplements for Healthy People - Vitacost Health Library
• Multiple Vitamin & Mineral Formulas - How to Select the Best - Dr. Murray (.pdf)
• What is an antioxidant and who should take one? - drugstore.com
• Antioxidants and Aging - Life Extension Magazine, 8/99
• Free Radial Theory of Aging - International Anti-Aging Systems
• Some Good Things to Say About Free Radicals - thenutritionreporter.com
• Books on antioxidants - Amazon.com

News & Research:

• Good News In Our DNA: Defects You Can Fix With Vitamins And Minerals - Science Daily, 6/2/08 - "He also is investigating how enzyme cofactors like vitamins and minerals fix defective enzymes. He suspects that supplements work by acting as chaperones to stabilize the proper folding of the enzyme, which is critical to its catalytic activity"
• How Antioxidant Therapy May Play A Role In The Treatment Of Type 2 Diabetes - Science Daily, 1/11/08 - "Mice fed a high-fat, high-sucrose diet (HFHSD) developed insulin resistance and type 2 diabetes ... mitochondrial defects were present in diabetic, but not pre-diabetic glucose intolerant, mice ... ROS production coincided with mitochondrial dysfunction, and antioxidant treatment blocked the mitochondrial alterations in muscle cells"
• Antioxidants may stop fat cells formation, says study - Nutra USA, 11/12/07 - "These results suggest that o-coumaric acid and rutin targeted for adipocyte functions could be effective in improving the symptoms of metabolic syndrome" - [Abstract]
• Antioxidants May Fight Fat - WebMD, 11/2/07 - "Those antioxidants didn't kill fat cells or slash the number of fat cells in the test tubes. Instead, they made fat cells cut their production of triglycerides, which are a heart hazard. The antioxidants did that by curbing an enzyme needed to make triglycerides ... That particular enzyme was most effectively reduced by the phenolic acid o-coumaric acid and the flavonoid rutin"
• Antioxidant To Retard Wrinkles Discovered - Science Daily, 8/30/07 - "Antioxidants operate against free radicals which cause a breakdown of many tissues in the body, including the skin. When found in small quantities in the body, free radicals are not harmful and are even involved in various physical processes. When there is an excess of free radicals, however, as occurs during normal aging or as a result of excessive exposure to ultra-violet radiation from the sun, the result, among other things, is a breakdown of the collagen and elastin fibers in the skin. When this happens, there is a loss of skin elasticity and the formation of wrinkles ... A problem with many of the commercial antioxidants found today in the market that are said to retard the aging process is that they oxidize quickly and therefore their efficiency declines with time"
• Chemists Discover New Way Antioxidants Fight Debilitating Diseases - Science Daily, 8/19/07 - "antioxidants even at low concentrations found in these foods bind to iron and copper and prevent DNA damage"
• Antioxidant Found In Many Foods And Red Wine Is Potent And Selective Killer Of Leukemia Cells - Science Daily, 4/23/07 - "anthocyanidins, a group of naturally occurring compounds widely available in fruits and vegetables as well as red wine, have chemopreventive properties ... the most common type of a naturally modified anthocyanidin, known as cyanidin-3-rutinoside, or C-3-R ... C-3-R caused about 50 percent of a human leukemia cell line known as HL-60 to undergo programmed cell death"
• Pros And Cons Of Antioxidants From Fruits And Vegetables - Science Daily, 4/18/07
• Nutrient Combo May Curb Hearing Loss - WebMD, 3/30/07 - "The guinea pigs that got the combination treatment of magnesium and vitamins A, C, and E had the least amount of noise-induced hearing loss and ear damage"
• Use of Some Antioxidant Supplements May Increase Mortality Risk - Doctor's Guide, 2/28/07 - "In an analysis that pooled all low-bias risk and high bias risk trials, there was no significant association between antioxidant use and mortality. In 47 low-bias trials involving 180,938 participants, the antioxidant supplements were associated with a 5% increased risk of mortality. Among low-bias trials, use of beta carotene, vitamin A, and vitamin E was associated with 7%, 16% and 4%, respectively, increased risk of mortality, whereas there was no increased mortality risk associated with vitamin C or selenium use" - [Abstract] - Note:  Beta-carotene is just one of over 600 carotenoids and taking just one may cause a deficiency of the others.  I had a couple articles on that but the links went dead.  Same with taking just the alpha tocopherol form (most common form) of vitamin E.  I've been saying for years that taking alpha tocopherol or beta-carotene alone causes more harm than good.  I get my beta-carotene from Dunaliella Salina Algae (Body Wise Brand), which contains the broad spectrum and vitamin E from Jarrow FamilE (contains all eight members of the vitamin E family) at iHerb.  See:
  • Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation - J Lipid Res. 1991 Aug;32(8):1325-32 - "gamma-Tocopherol significantly decreased in plasma and LDL during vitamin E (alpha-tocopherol) supplementation"
• Antioxidant Supplements Up Death Risk - WebMD, 2/27/07
• Replenishing The Aging Body’s Antioxidant Defenses - Life Extension Magazine, 1/07 - "Breakthroughs in nutritional science have led to the development of orally ingested, highly bioavailable forms of SOD. Combining orally available SOD with wolfberry offers a highly effective strategy to boost SOD levels and activity in the body. This novel combination protects against pain and inflammation, helps prevent a host of degenerative diseases, restores youthful energy and vitality, and promotes a long and healthy life span" - See SODzyme products at iHerb.
• Research Finds Antioxidant Therapies Do Not Interfere With Radiation Treatment - Science Daily, 11/12/06 - "Radiation Therapy for Prostate Cancer, was conducted by researchers ... Researchers found no difference between patients taking antioxidants and those who did not. Antioxidants used in the study included green tea extract, melatonin, high-potency multivitamins, vitamin C and vitamin E"
• Apple Juice May Boost Memory - WebMD, 8/4/06 - "consumption of antioxidant-rich foods such as apples and apple juice can help reduce problems associated with memory loss"
• Antioxidants May Slow Vision Loss - Science Daily, 7/20/06 - "Scientists at Johns Hopkins have successfully blocked the advance of retinal degeneration in mice with a form of retinitis pigmentosa (RP) by treating them with vitamin E, alpha-lipoic acid and other antioxidant chemicals"
• Mushrooms Full of Antioxidants - WebMD, 6/27/06 - "white button mushrooms -- the ones you might put on a nice, lean steak -- have more antioxidant capacity than tomatoes, green peppers, pumpkins, zucchini, carrots, or green beans"
• Healthy Antioxidants: How Much a Day? - WebMD, 5/11/06 - "They found the overall daily intake of anthocyanins was 12.5 milligrams per day, much less than estimates published in the 1970s that put average daily anthocyanin intake at 215 milligrams in summer and 180 milligrams in winter ... Incorporating frozen berries into the diet during the winter months or using nutritional supplements rich in anthocyanins may also help boost Americans' intake of these nutrients"
• Antioxidants, Mitochondrial Damage, and Human Aging - Life Extension Magazine, 2/06 - "some researchers believe that intramuscular mitochondrial DNA damage caused by free radicals may be a significant factor in the loss of muscle mass seen in the aged ... "
• Antioxidants Reduce Visual Acuity Loss in Patients with Advanced Age-Related Macular Degeneration - Doctor's Guide, 10/26/05 - "The high-dose formulation has been shown to have beneficial effects in reducing by 25% the risk of advanced AMD ... The first group received three antioxidant vitamins: vitamin C 500 mg, vitamin E 400 IU, and beta carotene 15 mg. Group two received zinc oxide 80 mg, plus cupric acid 2 mg. The third group received the antioxidant vitamins plus the zinc and cupric oxide"
• Antioxidants may not be answer to ageing - Nutra USA, 7/18/05
• Antioxidant-rich Diets Reduce Brain Damage From Stroke In Rats - Science Daily, 7/1/05 - "rats fed diets preventatively enriched with blueberries, spinach or an algae known as spirulina experienced less brain cell loss and improved recovery of movement following a stroke"
• Red Delicious apples pack most antioxidant punch - USATODAY.com, 6/5/05
• Oral antioxidants may be sun burn barrier - Nutra USA, 6/2/05
• Do Antioxidants Lengthen Life? - WebMD, 5/5/05 - "mice that made more of an antioxidant called catalase lived longer than normal ... How much extra time did the mice get? About five months, on average -- an 18.5% increase in life span for a mouse ... Heart disease, cataract development, and other signs of age-related damage were delayed or reduced"
• Antioxidants teach old dogs new tricks - Nutra USA, 1/18/05 - "old dogs that were on diet fortified with antioxidants such as vitamin E, vitamin C, and beta-carotene performed better on a variety of cognitive tests than dogs that were not on the diet"
• 'Purple Berries' Rank High In Antioxidants, USDA Study Says - Science Daily, 12/23/04
• Blueberries May Lower Blood Fat/Cholesterol - WebMD, 8/23/04 - "Pterostilbene -- the fat-fighting compound in blueberries -- has been found to have cancer-fighting and diabetes-fighting properties"
• Antioxidants During Pregnancy May Help Prevent Birth Defects Tied To Alcohol - Science Daily, 6/21/04
• Antioxidant Riches Found in Unexpected Foods - WebMD, 6/17/04
• Largest USDA Study Of Food Antioxidants Reveals Best Sources - Science Daily, 6/17/04 - "Cranberries, blueberries, and blackberries ranked highest among the fruits studied. Beans, artichokes and Russet potatoes were tops among the vegetables. Pecans, walnuts and hazelnuts ranked highest in the nut category"
• When Good Antioxidants Are Bad - WebMD, 6/14/04
• Do Antioxidants Contribute to Heart Disease? - WebMD, 5/3/04
• Honey Sweetens Your Health - WebMD, 3/29/04
• Diet May Improve Cognition, Slow Aging, And Help Protect Against Cosmic Radiation - Intelihealth, 11/10/03 - "The role of diet in cognitive function is one of the vastly understudied areas in the neurosciences ... old dogs that were on an antioxidant diet performed better on a variety of cognitive tests than dogs that were not on the diet ... aged rats on the blueberry-enriched diet had lower NF-kappaB levels than aged rats fed a control data ... among the aged rats, the higher the NF-kappaB levels, the poorer their memory scores"
• Antioxidants May Protect Women From Alzheimer's - Clinical Psychiatry News, 10/03 - "Compared with women in the lowest quartile of overall antioxidant consumption, those in the highest quartile had an OR of 0.39 for Alzheimer's disease ... When their diets were analyzed for specific antioxidants, women who consumed the most vitamin C and lycopene also had a significantly lower risk of cognitive decline"
• Can healthier living help your skin? - MSNBC, 9/5/03 - "Antioxidants are currently considered to be potent skin protectors. Normal body processes produce free radicals, highly reactive molecules that damage the DNA of our cells ... Ultraviolet light, smoking, alcohol and pollution increase free radical formation. Researchers say damage from free radicals leads to skin wrinkling, redness, brown “age spots” and increased risk of skin cancer. Antioxidants neutralize free radicals and even repair some of the damage done ... For now, scientists aren’t sure whether antioxidants are best applied in lotions or creams or consumed in foods or supplements"
• What do you think of the new study showing that antioxidants don’t cut the risk of heart disease - Dr. Weil, 7/14/03 - "If you want to supplement your diet, take a product that provides as many members of this family of protective pigments as possible: alpha-carotene, lutein, zeaxanthin, lycopene, etc. As for vitamin E, most studies use synthetic alpha-tocopherol. I recommend using natural vitamin E supplements that provide all four tocopherols and all four tocotrienols"
• Antioxidants May Protect Against Alcohol Damage - Intelihealth, 6/3/03 - "fed rats a liquid diet containing alcohol for six weeks ... They found a 66 percent decrease in the number of new cells in crucial parts of the brain and an increase in cell death of more than 227 percent ... But in rats that also received injections of the antioxidant ebselen, the damage to developing cells did not occur ... The antioxidant ebselen was used because it is known to have protective effects in the liver and digestive tract and has few side effects in humans"
• Three-year Follow-up Shows Antioxidant Treatment Improves Friedreich's Ataxia - Doctor's Guide, 11/15/02
• More Antioxidants, Less Fat May Reduce Alzheimer's Risk - Clinical Psychiatry News, 10/02 - "Data are now strong enough to recommend a dietary strategy for reducing Alzheimer's disease (AD) risk that includes low fat intake and high consumption of fish and antioxidants, along with vitamin E, folic acid, and vitamins B6 and B12 supplements"
• MEDLINE Abstracts: Antioxidants and the Aging Brain - Medscape, 9/27/02 - "Combinations of antioxidants might be of even greater potential benefit for AD, especially if the agents worked in different cellular compartments or had complementary activity (e.g. vitamins E, C and ubiquinone). Naturally-occurring compounds with antioxidant capacity are available and widely marketed (e.g. vitamin C, ubiquinone, lipoic acid, beta-carotene, creatine, melatonin, curcumin) and synthetic compounds are under development by industry" - Again, a broad spectrum of anti-oxidants, not just one or two.
• Antioxidant Reduces Stroke Damage - WebMD, 10/1/02 - "A new study shows the antioxidant, known as AEOL 10150, neutralized hazardous free radicals and prevented cell death in a mouse model of stroke. Researchers say the antioxidant is designed to mimic a natural antioxidant, but it works against a wider range of free radicals and also lasts longer in the body" - That last sentence is why I take as large a variety of anti-oxidants as possible though out the day.  I had a good article on my home page that explained why different anti-oxidants were required by various free radicals but the link went dead.
• Fat Abnormalities Hold Gehrig's Clue - Intelihealth, 9/16/02 - "Free radicals have long been thought to play a role in ALS, and some ALS specialists advise taking antioxidant vitamins in hopes of curbing them. In Mattson's experiment, published in this month's Annals of Neurology, free radicals caused ceramides to rise inside those crucial nerve cells ... Indeed, doctors like Newman expect medications, not diet, to ultimately hold the key. For now, Newman advises patients just to eat the moderate-fat diet the government already recommends for a healthy heart and take antioxidants such as vitamin E as a precaution"
• Antioxidants Fight Alzheimer's - WebMD, 6/25/02
• Your Health - Time Magazine, 6/24/02 - "High-fat, high-calorie fast-food meals don't just make you fat; they may also raise the level of free radicals in the blood, triggering inflammation that can damage the lining of blood vessels. That's the bad news. The good news is that taking a few antioxidant vitamins such as E and C with your fast food can nullify the inflammatory response"
• High Oxidative Stress, Low Antioxidant Status In Alzheimer Disease - Doctor's Guide, 6/3/02 - "Lymphocyte DNA 8-OHdG content in people AD may thus reflect a condition of increased oxidative stress related to a poor antioxidant status ... researchers also noted a significant inverse relationship between lymphocyte DNA 8-OHdG content [a marker of oxidative damage to DNA] and plasma levels of lycopene, lutein, a-carotene and b-carotene, respectively"
• Nutrition for the Skin - What You Should Know Before Undergoing a Surgical Procedure - Wellness Insider, 5/23/02 - "free radicals can accelerate the aging process of the skin, resulting in wrinkles and sunspots, not to mention an increased risk of skin cancer ... These antioxidants are important in protecting you from disease and can help shield you from skin cancer, maintain youthful, healthy skin, and even help to promote and expedite the healing process after a surgical procedure"
• Say Cheers: White Wine May Aid Lungs - Doctor's Guide, 5/21/02
• The Lungs Favor White Wine - WebMD, 5/20/02 - "those studies have shown that a daily dose of 1 to 3 glasses of red wine can improve cardiovascular health ... We found that white wine intake was strongly associated with better [lung] function ... One glass of wine per day equaled a 1.5% higher lung function, adding one or two more years to the person's lifetime; 3 glasses a day improved lung capacity by 3% ... He speculates that white wine drinkers have higher levels of vitamin antioxidants in their blood" - Also see grape seed extract/Pycnogenol and flavonoids.
• Black Raspberries Fight Cancer - WebMD, 5/3/02 - "Earlier studies have shown that blueberries and strawberries also have cancer-preventing properties. But black raspberries seem to work even better. Berries are chock full of antioxidants, chemicals that help block tumors from forming. Antioxidants sop up cancer-causing molecules called free radicals -- damaging substances produced from your body's everyday functions"
• Gene Scientists Find Clues To Why We Age - Intelihealth, 4/12/02
• Vitamin C And E Slow Arteriosclerosis After Heart Transplant - Doctor's Guide, 3/28/02
• Vitamins Help After Heart Transplant - WebMD, 3/28/02 - "The plaque-fighting benefits of the antioxidant supplements were even greater than those found using statin medications, which have already been shown to slow hardening of the arteries after transplants. Previous research has shown that antioxidants, such as vitamin C and E, can promote heart health by reducing blood clots and keeping the blood vessels flexible"
• Oxidative Stress Associated With Acute Abdominal Pain Severity - Doctor's Guide, 3/22/02 - "Compared to healthy controls, serum from patients presenting with acute abdominal pain showed lower total antioxidant capacity"
• The Cleveland Clinic: Eating to Prevent Cancer - WebMD - "Free radicals are one of the by-products of oxygen use by every cell in our body. These substances damage the body's cells through oxidation, the same process that rusts metal and turns butter rancid. Oxidation has also been shown to contribute to heart disease, cataracts, aging, and infections ... The body's cells have a natural defense strategy against free radicals and are able to repair the damage caused by them. However antioxidants, such as selenium and beta-carotene, help reinforce this protection"
• Antioxidants Shrink Cataract Risk By More Than Half - Intelihealth, 2/28/02
• Researchers Call Herbs Rich Source Of Healthy Antioxidants; Oregano Ranks Highest - Intelihealth, 1/7/02 - "Herbs have higher antioxidant activity than fruits, vegetables and some spices, including garlic ... Wang studied and compared the antioxidant activity of 39 commonly used herbs grown in the same location and conditions ... the herbs with the highest antioxidant activity belonged to the oregano family. In general, oregano had 3 to 20 times higher antioxidant activity than the other herbs studied ... Oregano has 42 times more antioxidant activity than apples, 30 times more than potatoes, 12 times more than oranges and 4 times more than blueberries ... herbs have emerged as a quick and easy way to get a concentrated source of antioxidants - without all the extra calories of whole foods"
• Intake Of Apples And Selenuim Affects Incidence Of Asthma - Intelihealth, 12/13/01 - "Eating at least two or more apples per week and a higher intake of the essential metal selenium can protect against asthma in adults, according to British researchers ... They reported on a population-based, case-control study to determine whether asthma is less common and less severe in adults who consume more dietary antioxidants"
• Antioxidants, At Certain Levels, May Reduce Blood Pressure - Doctor's Guide, 11/14/01 - "increasing levels of serum beta- carotene were associated with significant reductions in systolic blood pressure, while increasing levels of serum vitamin C were associated with significant reductions in diastolic pressure ... In contrast, serum levels of vitamin E were associated with significant increases in diastolic blood pressure"
• Antioxidants Like Vitamin C Soothe Damaging Effects of Pollution - WebMD, 9/27/01 - "antioxidant supplements can reduce the harmful effects of ozone gas on our lungs ... Ozone gas, the main chemical in smog, affects millions of Americans daily, and previous studies have shown that this highly active gas leads to decreases in lung function ... the group taking the antioxidant supplements had higher levels of both vitamins C and E in their blood, but they also saw that this group had a 25%-30% improvement in lung function tests compared to those taking placebo"
• An Apple a Day May Really Keep the Doctor Away, Apples, Tomatoes, and Other Fruits Offer Lung Protection - WebMD, 5/21/01 - "those who ate more apples and tomatoes had lungs that were, in effect, three years younger on average than those who ate less fruits and vegetables"
• Experiments Extend Life Of Nematode - Intelihealth, 9/1/00
• Smoking Takes the Power Out of Antioxidants - Nutrition Science News, 8/00
• Diets High in Antioxidants May Reduce Risk of Alzheimer's Disease - WebMD, 7/12/00
• Study Examines Red Wine Antioxidant - Intelihealth, 6/30/00
• Study Suggests Certain Vitamins Protect Against Deadly Lung Disease - WebMD, 6/5/00
• Chocolate: A heart-healthy confection? - CNN, 2/2/00
• Study Says Apples Help Breathing - Intelihealth, 1/20/00
• Science takes cellular approach to explore aging process - CNN, 1/4/00
• Antioxidants Extend Life - Life Enhancement Magazine, 8/99
• Antioxidants and Aging - Life Extension Magazine, 8/99
• Antioxidants Said Possible Fighter Of Killer Rare Disease - Intelihealth, 8/17/99
• Anti-aging nutrition secrets - CNN, 8/4/99
• Fountain of youth could be in the produce aisle - CNN, 4/5/99
• Study Finds Vitamin Supplements Could Reduce Hospital Costs By Nearly $20 Billion - Council for Responsible Nutrition
• Antioxidants May Reduce Harmful Complications Of Diabetes - Doctor's Guide, 4/20/98
• Free Radical Production Contributes to Cardiovscular Disease In African Americans - Doctor's Guide, 11/11/97
• Vitamin Supplements May Reduce Colon Cancer Risk - Doctor's Guide, 11/6/97
• Report: Only 1 percent of U.S. kids eat properly - CNN, 9/2/97
• Military Program Proposes Saving Money Through Vitamin Supplementation - Doctor's Guide, 5/22/97
• Vitamin Supplements May Help Asthmatics Cope With Air Pollution - Doctor's Guide, 5/20/97
• Top Ten Life Extension Drugs - Life Extension Magazine, 9/95

Abstracts:

• Comparison of Antioxidant Potency of Commonly Consumed Polyphenol-Rich Beverages in the United States - J Agric Food Chem. 2008 Jan 26 - "pomegranate juice (PJ) ... PJ had the greatest antioxidant potency composite index among the beverages tested and was at least 20% greater than any of the other beverages tested. Antioxidant potency, ability to inhibit LDL oxidation, and total polyphenol content were consistent in classifying the antioxidant capacity of the polyphenol-rich beverages in the following order: PJ > red wine > Concord grape juice > blueberry juice > black cherry juice, açaí juice, cranberry juice > orange juice, iced tea beverages, apple juice. Although in vitro antioxidant potency does not prove in vivo biological activity, there is also consistent clinical evidence of antioxidant potency for the most potent beverages including both PJ and red wine" - See Pomegranate Juice Extracts at iHerb.
• Effects of flavonoids and phenolic acids on the inhibition of adipogenesis in 3T3-L1 adipocytes - J Agric Food Chem. 2007 Oct 17;55(21):8404-10 - "These results suggest that o-coumaric acid and rutin targeted for adipocyte functions could be effective in improving the symptoms of metabolic syndrome"
• Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis - JAMA. 2007 Feb 28;297(8):842-57
• Lymphocyte Oxidative DNA Damage and Plasma Antioxidants in Alzheimer Disease - Archives of Neurology, 5/02 - "Markers of oxidative damage are increased in AD and correlate with decreased levels of plasma antioxidants. These findings suggest that lymphocyte DNA 8-OHdG content in patients with AD reflects a condition of increased oxidative stress related to a poor antioxidant status"
• Dietary intake of antioxidants and risk of age-related macular degeneration - JAMA. 2005 Dec 28;294(24):3101-7 - "In this study, a high dietary intake of beta carotene, vitamins C and E, and zinc was associated with a substantially reduced risk of AMD in elderly persons"

Where to purchase anti-oxidants separately:

Related Searches:

• Doctor's Guide search of antioxidants
• Doctor's Guide (2) search of antioxidant
• Intelihealth search of antioxidant
• Life Extension Foundation search
• Medline search of antioxidants
• Medscape search of antioxidant
• The Natural Pharmacist search of antioxidants
• Nutrition Science News search
• WebMD search of antioxidants

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