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Home > Health Conditions > Inflammation

Inflammation

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  • Effect of magnesium supplementation on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials - Curr Pharm Des. 2017 May 25 - "Results of the present meta-analysis indicated that magnesium supplementation reduces CRP levels among individuals with inflammation (CRP levels > 3 mg/dL). This finding suggests that magnesium supplements may have a beneficial role as an adjuvant for the management of low-grade chronic systemic inflammation" - [Nutra USA] - See Magtein at Amazon.com.
  • Lutein exerts anti-inflammatory effects in patients with coronary artery disease - Atherosclerosis. 2017 May 6;262:87-93 - "stable angina (SA) ... peripheral blood mononuclear cells (PBMCs) ... Only lutein + zeaxanthin were inversely correlated with IL-6 in SA patients at baseline (r = -0.366, p < 0.001) and follow-up (r = -0.546, p < 0.001). Ex vivo, lutein was taken up by PBMCs from SA patients in a dose- and time-dependent manner. Pre-treatment with lutein dose-dependently lowered LPS-induced secretion of IL-6, IL-1β (p < 0.01) and TNF (p < 0.05), and also reduced IL-6, IL-1β and TNF mRNA expression (p < 0.05)" - See lutein at Amazon.com.
  • Curcumin Reduces Muscle Damage and Soreness Following Muscle-Damaging Exercise - FASEB Journal, Apr 2017 - "The antioxidant curcumin is able to counteract the two leading causes of muscle damage, oxidative stress and inflammation, as it interacts with multiple inflammatory pathways ... randomly assigned to ingest 50 mg Curcuminoids (in the form of 250 mg CurcuWIN®), 200 mg Curcuminoids (in the form of 1,000 mg CurcuWIN®), or placebo (PLA) for eight weeks ... These data demonstrate curcuminoids reduce muscle damage and improve muscle soreness in healthy young subjects following a bout of muscle damaging exercise. Faster recovery allows for consistent training at competition intensity and might lead to enhanced adaptation rate and performance" - [Nutra USA] - See CurcuWIN® at Amazon.com.
  • Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction - Cell Host Microbe. 2017 Apr 12 - "Levels of inflammatory mediators in circulation are known to increase with age, but the underlying cause of this age-associated inflammation is debated ... These data suggest that aging-associated microbiota promote inflammation and that reversing these age-related microbiota changes represents a potential strategy for reducing age-associated inflammation and the accompanying morbidity" - [Nutra USA] - See probiotic products at Amazon.com.
  • Analgesic and Anti-Inflammatory Activities of Resveratrol through Classic Models in Mice and Rats - Evid Based Complement Alternat Med. 2017;2017:519756 - "these results indicated that RSV had potent analgesic and anti-inflammatory activities and could be a potential new drug candidate for the treatment of inflammation and pain" - See Reserveage Nutrition - Resveratrol with Pterostilbene 500mg, Cellular Age-Defying Formula, 60 veg capsules at Amazon.com.
  • 'Inflamm-aging: ' Alcohol makes it even worse - Science Daily, 6/28/16 - "The immune system in the elderly is dysfunctional and infections are more prevalent, more severe, and harder to defeat. Drinking alcohol has a variety of damaging effects on the immune system and organs -- like the gut, liver and lung -- which can be worsened by pre-existing conditions as well as consumption of prescription and over-the-counter medications that aged individuals often take ... We know that even healthy elderly individuals have an elevated basal inflammatory state, known as 'inflamm-aging.' Advanced age alone is a risk factor for a poor prognosis after injury or infection. Adding alcohol to the fragile immune milieu of the aged reduces their ability to fight infections ... alcohol exposure makes macrophages less effective at clearing pathogens and releasing molecules important for recruiting other immune cells to the site of infection, and that this is worsened in the elderly ... Even short-term exposure of macrophages to alcohol reduces their ability to migrate to a site of infection as well as their ability to destroy the pathogen"
  • Anti-Inflammatory Effects of Spirulina platensis Extract via the Modulation of Histone Deacetylases - Nutrients. 2016 Jun 21;8(6) - "We previously demonstrated that the organic extract of Spirulina platensis (SPE), an edible blue-green alga, possesses potent anti-inflammatory effects ... Our results suggest that SPE increased global histone H3 acetylation by facilitating HDAC protein degradation, but decreases histone H3K9/K14 acetylation and p65 binding at the promoters of Il-1β and Tnfα to exert its anti-inflammatory effect" - See spirulina at Amazon.com.
  • The Effect of Coenzyme Q10 Supplementation on Pro-Inflammatory Factors and Adiponectin in Mildly Hypertensive Patients: A Randomized, Double-Blind, Placebo-Controlled Trial - Int J Vitam Nutr Res. 2015;85(3-4):156-64 - "Sixty mildly hypertensive patients were randomly divided into two groups: placebo (PG, n = 30) and coenzyme Q10 (QG, n = 30). The QG was given 1 capsule containing 100 mg Q10 per day ... The mean enhancement in adiponectin of QG was significantly higher than PG (from 21.1 ± 14.5 to 24.2 ± 15.5 ng/ml, P = 0.04). Significant declines in the median of IL6 (from 23 to 16 pg/ml, P = 0.001) and in the mean of hs-CRP were also observed in QG after intervention (from 3.53 ± 3.36 to 2.62 ± 2.51 mg/L, P = 0.03)" - See ubiquinol products at Amazon.com.
  • Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin - BBA Clinical Jun 16 - "The purpose of this study was to determine the effects of oral curcumin supplementation (Longvida® 400 mg/days) on muscle & ADL soreness, creatine kinase (CK), and inflammatory cytokines (TNF-α, IL-6, IL-8, IL-10) following EMID (eccentric-only dual-leg press exercise) ... Curcumin supplementation resulted in significantly smaller increases in CK (− 48%), TNF-α (− 25%), and IL-8 (− 21%) following EIMD compared to placebo ... The observed improvements in biological inflammation may translate to faster recovery and improved functional capacity during subsequent exercise sessions" - [NutraUSA] - See curcumin products at Amazon.com.
  • The Dietary Inflammatory Index Is Associated with Prostate Cancer Risk in French Middle-Aged Adults in a Prospective Study - J Nutr. 2016 Mar 9 - "Chronic inflammation is one of the mechanisms involved in carcinogenesis. Diet is a major source of pro- and anti-inflammatory compounds ... Consistent with mechanistic data, findings from this study indicated that proinflammatory diets are associated with increased prostate cancer risk and, in low-to-moderate alcohol drinkers, with increased overall and breast cancer risk"
  • Dairy Consumption Lowers Systemic Inflammation and Liver Enzymes in Typically Low-Dairy Consumers with Clinical Characteristics of Metabolic Syndrome - J Am Coll Nutr. 2015 Nov 23:1-7 - "This was a randomized study in which participants consumed low-fat dairy (LFD) (10 oz 1% milk, 6 oz nonfat yogurt, 4 oz 2% cheese) or a carbohydrate-based control (CNT) (1.5 oz granola bar and 12 oz 100% juice) for 6 weeks ... Participants had lower concentrations of both hepatic alanine aminotransferase (p < 0.05) and aspartate aminotransferase (p < 0.005) after the LFD period. No significant changes in any of the plasma inflammatory compounds were found when all data were analyzed together. In contrast, expression of IL-1b and IL-6 were reduced by 46% and 63%, respectively, compared to the control period ... We conclude that three dairy servings per day improved both liver function and systemic inflammation in subjects with MetS" - See my Greek yogurt recipe at the top of my yogurt page.
  • Low n-6/n-3 PUFA Ratio Improves Lipid Metabolism, Inflammation, Oxidative Stress and Endothelial Function in Rats Using Plant Oils as n-3 Fatty Acid Source - Lipids. 2015 Nov 2 - "The 1:1 and 5:1 ratio groups had significantly decreased serum levels of total cholesterol, low-density lipoprotein cholesterol, and proinflammatory cytokines compared with the 20:1 group ... The 1:1 group had a significantly decreased lipid peroxide level compared with the other groups ... We demonstrated that low n-6/n-3 PUFA ratio (1:1 and 5:1) had a beneficial effect on cardiovascular risk factors by enhancing favorable lipid profiles, having anti-inflammatory and anti-oxidative stress effects, and improving endothelial function. A high n-6/n-3 PUFA ratio (20:1) had adverse effects"
    • Omega-6 fatty acids - University of Maryland Medical Center - "The typical American diet tends to contain 14 - 25 times more omega-6 fatty acids than omega-3 fatty acids"
  • Using Antidiabetic Therapies to Treat Alzheimer Disease - Medscape, 8/27/15 - "Inflammatory molecules have a negative effect on the brain and also contribute to insulin resistance" - See metformin at IAS.
  • Probiotics Improve Inflammation-Associated Sickness Behavior by Altering Communication between the Peripheral Immune System and the Brain - J Neurosci. 2015 Jul 29 - "Patients with systemic inflammatory diseases (e.g., rheumatoid arthritis, inflammatory bowel disease, chronic liver disease) commonly develop debilitating symptoms (i.e., sickness behaviors) that arise from changes in brain function. The microbiota-gut-brain axis alters brain function and probiotic ingestion can influence behavior ... This research shows that probiotics, when eaten, can improve the abnormal behaviors (including social withdrawal and immobility) that are commonly associated with inflammation. Probiotics are able to cause this effect within the body by changing how the immune system signals the brain to alter brain function. These findings broaden our understanding of how probiotics may beneficially affect brain function in the context of inflammation occurring within the body and may open potential new therapeutic alternatives for the treatment of these alterations in behavior that can greatly affect patient quality of life" - See probiotic products at Amazon.com.
  • Increased Dietary Inflammatory Index (DII) Is Associated With Increased Risk of Prostate Cancer in Jamaican Men - Nutr Cancer. 2015 Jul 30 - "We examined the association between a newly developed dietary inflammatory index (DII) and prostate cancer in a case-control study of 40-80 yr old Jamaican males ... Men in the highest quartile of the DII were at higher risk of prostate cancer [odds ratio (OR) = 2.39; 95% confidence interval (CI) = 1.14-5.04; Ptrend = 0.08] compared to men in the lowest DII quartile"
  • Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players - Evid Based Complement Alternat Med. 2015;2015 - "The plasma muscle enzymes levels were reduced significantly by Asx supplementation and by regular training. The increase in neutrophil count and hs-CRP level was found only in placebo group, indicating a significant blunting of the systemic inflammatory response in the subjects taking Asx. This study indicates that Asx supplementation improves sIgA response and attenuates muscle damage, thus preventing inflammation induced by rigorous physical training. Our findings also point that Asx could show significant physiologic modulation in individuals with mucosal immunity impairment or under conditions of increased oxidative stress and inflammation" - See Puritan's Pride Lutein 20 mg with Zeaxanthin-120 Softgels at Amazon.com.
  • Higher dietary anthocyanin and flavonol intakes are associated with anti-inflammatory effects in a population of US adults - Am J Clin Nutr. 2015 May 27 - "calculated from validated food-frequency questionnaires ... an inverse association between higher anthocyanin and flavonol intakes and IS was observed with a mean ± SE difference between quintile categories 5 and 1 of -1.48" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com and Jarrow Formulas OPCs + 95 100mg, Grape Seed Extract, 100 Capsules at Amazon.com.
  • Lutein suppresses inflammatory responses through Nrf2 activation and NF-κB inactivation in lipopolysaccharide-stimulated BV-2 microglia - Mol Nutr Food Res. 2015 May 27 - "These results suggest that lutein attenuates neuroinflammation in LPS-activated BV-2 microglia partly through inhibiting p38-, JNK- and Akt-stimulated NF-κB activation and promoting ERK-induced Nrf2 activation, suggesting that lutein has great potential as a nutritional preventive strategy in inflammation-related neurodegenerative disorders" - See lutein at Amazon.com.
  • Component of red grapes, wine could help ease depression - Science Daily, 3/30/15 - "the bullied rats were given a daily dose of resveratrol roughly equivalent to the amount found in six glasses of wine. They found that resveratrol blocked the increased inflammation in the brain and also prevented the depressive-like behaviors in animals that would have normally developed those behaviors ... administering resveratrol blocks the inflammation we would normally see in animals undergoing the bullying stress and brings it to control levels. We saw that consistently with IL-1ß [a pro-inflammatory protein] and many of the other inflammatory markers that we analyzed ... resveratrol has anti-inflammatory potential in the brain, not just on levels of inflammation circulating in the body" - See ReserveAge Resveratrol Vegetarian Capsules, 500 Mg, 60-Count at Amazon.com.
  • Vitamin C supplementation in the critically ill patient - Curr Opin Clin Nutr Metab Care. 2015 Jan 29 - "Restoration of normal plasma levels in inflammatory patients requires the administration of 3 g/day for several days ... The recent research on the modulation of oxidative stress and endothelial protection offer interesting therapeutic perspectives, based on the biochemical evidence, with limited or even absent side-effects" - See American Health Products - Ester C W/Citrus Bioflavonoids, 1000 mg, 180 veg tablets at Amazon.com.
  • Chemical in coffee may help prevent obesity-related disease - Science Daily, 11/14/14 - "chlorogenic acid, or CGA, significantly reduced insulin resistance and accumulation of fat in the livers of mice who were fed a high-fat diet ... which is found in great abundance in coffee, but also in other fruits and vegetables like apples, pears, tomatoes and blueberries ... CGA was not only effective in preventing weight gain, but it also helped maintain normal blood sugar levels and healthy liver composition ... CGA is a powerful antioxidant that reduces inflammation" - See chlorogenic acid at Amazon.com.
  • Association between serum vitamin D concentrations and inflammatory markers in the general adult population - Metabolism. 2014 May 9 - "Our study confirms a potential role of 25(OH)D in chronic inflammation" - See vitamin D at Amazon.com.
  • Associations Between Glucosamine and Chondroitin Supplement Use and Biomarkers of Systemic Inflammation - J Altern Complement Med. 2014 Apr 16 - "high-sensitivity C-reactive protein (hsCRP) ... urinary prostaglandin E2-metabolite (PGE-M) ... High users (14 or more pills/week) of chondroitin had 36% lower hsCRP (ratio, 0.64; 95% confidence interval [CI], 0.39-1.04; p for trend=.03) and 27% lower PGE-M (ratio, 0.73; 95% CI, 0.5-0.98; p for trend=.07) than nonusers. Compared with nonusers, high users of glucosamine had 28% lower hsCRP (ratio, 0.72; 95% CI, 0.47-1.08; p for trend=.09) and 24% lower PGE-M (ratio, 0.76; 95% CI, 0.59-0.97; p for trend=0.10)" - See chondroitin sulfate at Amazon.com and glucosamine products at Amazon.com.
  • Lack of Vitamin D Linked to CVD Biomarkers, Inflammation - Medscape, 2/27/14 - "Compared with individuals with sufficient serum levels of vitamin D (>75 nmol/L), those who were deficient (<25 nmol/L) had significantly higher levels of the inflammatory biomarkers IL-6 and CRP, and they were more likely to have CRP:IL-10 and IL-6:IL-10 ratios above 2, where IL-10 is an anti-inflammatory biomarker ... I think all of us now think that inflammation is a critical factor in a lot of disease . . . so there's some rationale for thinking about trying to reduce chronic inflammation with something as simple as vitamin D, and it may have a further effect on atherosclerotic risk of cardiovascular disease" - See vitamin D at Amazon.com.
  • Ingredients in Chocolate, Tea, Berries Could Guard Against Diabetes - Science Daily, 1/20/14 - "We also found that those who ate the most anthocyanins were least likely to suffer chronic inflammation -- which is associated with many of today's most pressing health concerns including diabetes, obesity, cardiovascular disease, and cancer" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Anti-inflammatory effects of fish oil in ovaries of laying hens target prostaglandin pathways - Lipids Health Dis. 2013 Oct 24;12(1):152 - "The domestic hens spontaneously develop ovarian adenocarcinomas that share similar histological appearance and symptoms such as ascites and metastasis with humans. There is a link between chronic inflammation and cancer ... Our findings suggest that the lower doses of fish oil reduce inflammatory PG and may be an effective approach in preventing ovarian carcinogenesis. These findings may provide the basis for clinical trials utilizing fish oil as a dietary intervention targeting prostaglandin biosynthesis for the prevention and treatment of ovarian cancer" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Amino acid offers potential therapeutic alternative in psychiatric disorders - Science Daily, 10/8/13 - "drug discovery is at a near standstill for treating psychiatric disorders such as schizophrenia, bipolar disorder, depression and common forms of autism ... According to Professor Berk, there is now an incontrovertible evidence base that these disorders share inflammation and oxidative stress as part of their disease physiology ... The amino acid, NAC, seems to have multiple effects on all these pathways: it boosts glutathione, which is the body’s major antioxidant defence; has anti-inflammatory properties; enhances levels of nerve cell growth proteins and the growth of new neurons; and reduces cell death pathways. It also appears to reduce dysfunction of mitochondria ... NAC reduces the core symptoms of schizophrenia including negative symptoms such as improved apathy, social interaction and motivation. It also appears to reduce depression in people with bipolar disorder and at this meeting ... there is intriguing evidence that it reduces cravings in a number of addictions including cocaine, cannabis and cigarette smoking" - See n-acetyl cysteine at Amazon.com.
  • Taurine improves obesity-induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages - Mol Nutr Food Res. 2013 Aug 12 - "It is increasingly accepted that chronic inflammation is a feature of obesity. Obesity-induced inflammation triggers enhanced recruitment of macrophages into the adipose tissue. Depending on their phenotype, macrophages can be designated either as pro-inflammatory M1 macrophages or anti-inflammatory M2 macrophages ... Our findings indicate that taurine treatment attenuates the infiltration of adipose tissue by macrophages and modulates the phenotype of macrophages, which suggest that taurine is a valuable food constituent with a potential to attenuate chronic inflammation in adipose tissue and improve obesity-related insulin resistance" - See taurine at Amazon.com.
  • Are Curcuminoids Effective C-Reactive Protein-Lowering Agents in Clinical Practice? Evidence from a Meta-Analysis - Phytother Res. 2013 Aug 7 - "Inflammation plays a pivotal role in the pathogenesis of atherosclerosis and cardiovascular disease (CVD). In this context, C-reactive protein (CRP) has been identified as a strong predictor and independent risk factor of CVD. Curcuminoids are multifunctional natural product with promising cardioprotective and anti-inflammatory properties ... PubMed/MEDLINE and SCOPUS databases were searched ... Compared with placebo, supplementation with curcuminoids was associated with a significant reduction in circulating CRP levels (weighed mean difference: -6.44 mg/L; 95% CI: -10.77 - -2.11; p = 0.004). This significant effect was maintained in subgroups of trials that used bioavailability-improved preparations of curcuminoids and had supplementation duration of ≥4 weeks, but not in the subgroups without these characteristics ... effect appears to depend on the bioavailability of curcuminoids preparations and also duration of supplementation" - See curcumin products at Amazon.com.
  • Scientists show how DHA resolves inflammation - Science Daily, 7/1/13 - "Chronic inflammation is a major factor in a wide range of problems from arthritis to cardiovascular disease, and DHA (found in fish oil) is known to temper this problem ... researchers found that macrophages (a type of white blood cell) use DHA to produce "maresins," which serve as the "switch" that turns inflammation off and switches on resolution" - See Jarrow Max DHA at Amazon.com.
  • Could a Diet High in Fish and Flax Help Prevent Broken Hips? - Science Daily, 6/27/13 - "The study showed that higher levels of omega-3 fatty acids from both plant and fish sources in those blood cells were associated with a lower likelihood of having fractured a hip ... The study also showed that as the ratio of omega-6 fatty acids to omega-3s increased, so did the risk for hip fracture ... Inflammation is associated with an increased risk of bone loss and fractures, and omega-3 fatty acids are believed to reduce inflammation ... omega-3 fatty acids have anti-inflammatory properties and omega-6 fatty acids seem to have both anti- and pro-inflammatory effects ... women who had the highest ratio of omega-6 to omega-3 fatty acids had nearly twice the risk of hip fractures compared to women with the lowest ratios. The current typical American diet contains between 15 and 17 times more omega-6 than omega-3, a ratio that previous research has suggested should be lowered to 4-to-1, or even 2-to-1, by increasing omega-3s, to improve overall health. The primary omega-6 fatty acid in the diet is linoleic acid, which composes about 99 percent of Americans' omega-6 intake and is found in corn, soybean, safflower and sunflower oils" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Omega-3 fatty acids in cancer - Curr Opin Clin Nutr Metab Care. 2013 Jan 7 - "Inflammation dictates tumour initiation, progression and growth. Omega-3 fatty acids exert anti-inflammatory effects, and therefore recent studies investigated their role in cancer prevention, in cancer cachexia treatment and in enhancement of antitumour therapies. Limited evidence suggests a role for omega-3 fatty acid supplementation in cancer prevention, but they have been shown to preserve muscle mass and function in cancer patients even during active treatment. During chemotherapy, omega-3 fatty acids may contribute to a reduced inflammatory response, but whether cancer treatment toxicity can be prevented remains to be assessed. Finally, small studies showed that omega-3 fatty acids increase response rate to chemotherapy" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Glucosamine, Chondroitin, Fish Oil May Reduce Inflammation - Medscape, 11/27/12 - "Inflammation is now recognized as a factor in cancer and cardiovascular disease as well as many rheumatoid diseases ... the researchers found hs-CRP reductions of 17% (95% confidence interval [CI], 7% - 26%) with glucosamine, 22% (95% CI, 8% - 33%) with chondroitin, and 16% (95% CI, 0.3% - 29%) with fish oil compared with participants who did not take the supplements" - See glucosamine products at Amazon.com, chondroitin sulfate at Amazon.com, Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Omega-3 supplements may slow a biological effect of aging - Science Daily, 10/1/12 - "In the study, lengthening of telomeres in immune system cells was more prevalent in people who substantially improved the ratio of omega-3s to other fatty acids in their diet ... Omega-3 supplementation also reduced oxidative stress, caused by excessive free radicals in the blood, by about 15 percent compared to effects seen in the placebo group ... Study participants took either 2.5 grams or 1.25 grams of active omega-3 polyunsaturated fatty acids ... The supplements were calibrated to contain a ratio of the two cold-water fish oil fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), of seven to one ... the typical American diet tends to be heavy on omega-6 fatty acids and comparatively low in omega-3s that are naturally found in cold-water fish such as salmon and tuna. While the ratio of omega-6 to omega-3 fatty acids averages about 15-to-1, researchers tend to agree that for maximum benefit, this ratio should be lowered to 4-to-1, or even 2-to-1 ... when the researchers analyzed the participants' omega-6 to omega-3 ratio in relationship to telomere lengthening, a lower ratio was clearly associated with lengthened telomeres ... omega-3 supplements lowered IL-6 by 10 to 12 percent, depending on the dose. By comparison, those taking a placebo saw an overall 36 percent increase in IL-6 by the end of the study ... This finding strongly suggests that inflammation is what's driving the changes in the telomeres" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Omega-3 lowers inflammation in overweight older adults - Science Daily, 6/21/12 - "Chronic inflammation is linked to numerous conditions, including coronary heart disease, Type 2 diabetes, arthritis and Alzheimer's disease, as well as the frailty and functional decline that can accompany aging ... Participants received either a placebo or one of two different doses of omega-3 fatty acids -- either 2.5 grams or 1.25 grams per day ... After four months, participants who had taken the omega-3 supplements had significantly lower levels in their blood of two proteins that are markers of inflammation, also called pro-inflammatory cytokines. The low-dose group showed an average 10 percent decrease in the cytokine interleukin-6 (IL-6), and the high-dose group's overall IL-6 dropped by 12 percent. In comparison, those taking a placebo saw an overall 36 percent increase in IL-6 by the end of the study ... The current typical American diet contains between 15 and 17 times more omega-6 than omega-3, a ratio that researchers suggest should be lowered to 4-to-1, or even 2-to-1, to improve overall health" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Low Vitamin B6 Linked to Inflammation - WebMD, 6/19/12 - "people with the lowest levels of vitamin B6 in their blood had the highest levels of chronic inflammation, based on a wide variety of indicators. Those with the most vitamin B6 circulating in the bloodstream were also the least likely to have indicators of inflammation ... chronic inflammation is an emerging risk factor for a wide range of health problems, including heart disease, stroke, and type 2 diabetes" - See vitamin B6 at Amazon.com.
  • The effect of pioglitazone treatment on 15-epi-lipoxin A(4) levels in patients with type 2 diabetes - Atherosclerosis. 2012 May 7 - "Arachidonic acid-derived eicosanoids (lipoxins and 15-epilipoxins) have a major role in resolution of inflammation. 15-epi-lipoxin A(4) (15-epi-LXA(4)) is a lipid mediator with strong anti-inflammatory and inflammation-resolving effects ... PIO 15 increased plasma 15-epi-LXA(4) levels (0.63 +/- 0.06-1.05 +/- 0.08 ng/mL, p < 0.01) and adiponectin levels (6.4 +/- 0.3-10.1 +/- 0.7 μg/mL, p < 0.001) and decreased fasting plasma glucose (125 +/- 8-106 +/- 9 mg/dL, p < 0.05), free fatty acids (FFA) (414 +/- 46-320 +/- 38 μmol/l, p < 0.05) and HOMA-IR (5.3 +/- 0.4 to 4.0 +/- 0.4, p < 0.05). Body weight (Δ = 0.2 kg) and HbA1c (7.4 +/- 0.2-7.1 +/- 0.2%) did not change significantly. PIO 30 treated patients had similar increase in plasma 15-epi-LXA(4) (0.64 +/- 0.10-1.08 +/- 0.09 ng/mL, p < 0.01), and decrease in plasma FFA (423 +/- 42-317 +/- 40 μmol/l, p < 0.05) despite a greater increase in plasma adiponectin (6.5 +/- 0.4-15.5 +/- 0.7 ug/mL, p < 0.001) and a greater reduction in HbA1c (8.7 +/- 0.5-7.4 +/- 0.3%, p < 0.01), FPG (159 +/- 16-120 +/- 10 mg/dL, p < 0.01), and HOMA-IR (6.6 +/- 0.8-4.4 +/- 0.4, p < 0.005). Furthermore, PIO 30 treated patients had a significant increase in body weight (Δ = 1.7 kg, p < 0.02)" - See pioglitazone at OffshoreRx1.com.
  • Why omega-3 oils help at the cellular level - Science Daily, 5/15/12 - "The scientists fed mouse macrophages -- a kind of white blood cell -- three different kinds of fatty acid: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (AA). EPA and DHA are major polyunsaturated omega-3 fatty acids, essential to a broad range of cellular and bodily functions, and the primary ingredient in commercial fish oil dietary supplements. AA is a polyunsaturated omega-6 fatty acid prevalent in the human diet ... They discovered that omega-3 fatty acids inhibit an enzyme called cyclooxygenase (COX), which produces the prostaglandin hormones that spark inflammation. The action is similar to what happens when one takes an aspirin, which disrupts the COX-2 signaling pathway, thus reducing inflammation and pain ... On the other hand ... omega-3 oils do not inhibit another group of enzymes called lipoxygenases (LOX), which are also produced by stimulated macrophages. One type of generated LOX enzyme in turn produces fat-signaling molecules called leukotrienes, which are pro-inflammatory. But Norris noted that LOX enzymes may also generate anti-inflammatory compounds called resolvins from EPA and DHA" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • How vitamin D inhibits inflammation - Science Daily, 2/23/12 - "Patients with chronic inflammatory diseases, such as asthma, arthritis and prostate cancer, who are vitamin D deficient, may benefit from vitamin D supplementation to get their serum vitamin D levels above 30 nanograms/milliliter ... Cells incubated with no vitamin D and in solution containing 15 ng/ml of vitamin D produced high levels of cytokines IL-6 and TNF-alpha, major actors in the inflammatory response. Cells incubated in 30 ng/ml vitamin D and above showed significantly reduced response to the LPS. The highest levels of inflammatory inhibition occurred at 50 ng/ml" - See vitamin D at Amazon.com.
  • Vitamin D Status and Cytokine Levels in Patients with Crohns Disease - Int J Vitam Nutr Res. 2011 Jul;81(4):205-10 - "Results: IL-10 levels were significantly lower in patients with vitamin D insufficiency compared with the vitamin D replete group (mean and SE 2.48 +/- 0.51 v 6.77 +/- 2.49 pg/mL, p < 0.001). There were, however, no differences in serum TNF-alpha or CRP levels based on vitamin D status. The use of a vitamin D supplement at a low dose (200 IU) did not significantly influence IL-10 levels. Conclusion: Circulating levels of IL-10, but not TNF-alpha, were significantly lower in CD patients with inadequate serum 25(OH)D. This suggests that poor vitamin D status may be linked to reduced anti-inflammatory capacity in this group" - See vitamin D at Amazon.com.
  • A diet rich in slowly digested carbs reduces markers of inflammation in overweight and obese adults - Science Daily, 1/11/12 - "Among overweight and obese adults, a diet rich in slowly digested carbohydrates, such as whole grains, legumes and other high-fiber foods, significantly reduces markers of inflammation associated with chronic disease ... a low-glycemic-load diet reduced a biomarker of inflammation called C-reactive protein by about 22 percent ... C-reactive protein is associated with an increased risk for many cancers as well as cardiovascular disease ... a low-glycemic-load diet modestly increased -- by about 5 percent -- blood levels of a protein hormone called adiponectin ... a low-glycemic-load diet modestly increased -- by about 5 percent -- blood levels of a protein hormone called adiponectin. This hormone plays a key role in protecting against several cancers, including breast cancer, as well as metabolic disorders such as type-2 diabetes, nonalcoholic fatty liver disease and hardening of the arteries"
  • Feeding the flame - The Daily, 9/27/11 - "The physical symptoms of chronic inflammation are wide, ranging from joint pain, gastrointestinal problems like bloating and diarrhea, skin problems and lack of energy. Experts warn that over time, low-grade, chronic inflammation can lead to more serious problems, such as Alzheimer’s, fibromyalgia, colon cancer and heart disease ... now we know that heart attacks rarely happen simply due to the buildup, and that inflammation plays a key role in weakening the plaque in the arteries, resulting in heart attacks and strokes ... Omega-3 fatty acids, found in oily fish like salmon and mackerel, are considered key players in the fight against chronic inflammation ... a diet high in carbohydrates stimulates the genes that cause inflammation in the body ... Other factors important in fighting inflammation include exercise, getting enough sleep, and reducing stress"
  • Harvard study supports coffee’s anti-diabetes potential - Nutra USA, 9/21/11 - "Five cups of coffee per day for two months were associated with significant metabolic benefits and live function ... the metabolic benefits were more pronounced in caffeinated coffee, a result that supports the hypothesis that caffeine is responsible for some of the apparent benefits ... Coffee is also a rich source of polyphenols ... one cup of the stuff could provide 350 milligrams of phenolics ... Of these, the most abundant compounds in coffee are chlorogenic acids, making up to 12 per cent of the green coffee bean. The most abundant of these compounds is caffeic acid ... recruited 45 healthy, overweight coffee drinking 40 year olds ... volunteers were asked to drink five cups of coffee per day of instant caffeinated coffee, decaffeinated coffee, or water for eight weeks ... coffee consumption was associated with a 60% reduction in blood levels of a compound called interleukin-6, which can promote inflammation, compared with the water group ... In addition, levels of adiponectin – a hormone released from fat cells that plays an important role in the regulation of insulin sensitivity and energy – also decreased in the caffeinated, but not decaffeinated group" - [Abstract]
  • Olive extract shows benefits for inflammatory bowel disease - Nutra USA, 9/12/11 - "Olive oil and the hydroxytyrosol it contains may reduce inflammation linked with the development of colitis ... Hydroxytyrosol is thought to be the main antioxidant compound in olives, and believed to play a significant role in the many health benefits attributed to olive oil. Previous research has linked the compound to cardiovascular benefits, with reductions in LDL or 'bad' cholesterol. Data has also suggested the compound may boost eye health and reduce the risk of against macular degeneration ... the olive oil-fed animals had an attenuation of the colonic damage, as well as a 50% reduction in the mortality rate caused by DSS. The results were improved further by hydroxytyrosol supplement ... levels of the pro-inflammatory compound interleuking-10 (IL-10) were “significantly improved” in both olive oil-fed groups" - [Abstract] - See olive leaf extract at Amazon.com.
  • A multi-nutrient supplement reduced markers of inflammation and improved physical performance in active individuals of middle to older age: a randomized, double-blind, placebo-controlled study - Nutr J. 2011 Sep 7;10(1):90 - "While exercise acts to combat inflammation and aging, the ability to exercise may itself be compromised by inflammation and inflammation's impact on muscle recovery and joint inflammation. A number of nutritional supplements have been shown to reduce inflammation and improve recovery. The purpose of the current investigation was to examine the effect of a multi-nutrient supplement containing branched chain amino acids, taurine, anti-inflammatory plant extracts, and B vitamins on inflammatory status, endothelial function, physical function, and mood in middle-aged individuals ...Thirty-one healthy and active men (N=16, mean age 56+/-6.0 yrs) and women (N=15, mean age=52+/-7.5 yrs) participated in this investigation. Subjects completed one 28 day cycle of placebo supplementation and one 28 day cycle of multi-nutrient supplementation (separated by a one week washout period) in a balanced, randomized, double-blind, cross-over design ... IL-6 significantly decreased in both men (from 1.2 +/- 0.2 to 0.7+/-0.4 pg * mL-1) and women (from 1.16+/-0.04 to 0.7+/-0.4 pg * mL-1). Perceived energy also improved for both men (placebo: 1.8 +/- 0.7; supplement: 3.7+/-0.8 AUC) and women (placebo: 1.2 +/- 0.7; supplement: 2.8+/-0.8 AUC). Alpha-1-antichymotrypsin (from 108.9+/-38.6 to 55.5+/-22.2 ug * mL-1), Creatine Kinase (from 96+/-34 to 67+/-23 IU * L-1), general pain, and joint pain decreased in men only, while anxiety and balance (from 0.52+/-0.13 to 0.45+/-0.12 cm) improved in women only. Men showed increased performance in vertical jump power (from 2642+/-244 to 3134+/-282 W) and grip strength (from 42.1+/-5.9 to 48.5+/-4.9 kg)" - See taurine at Amazon.com and BCAA products at Amazon.com.
  • Hydroxytyrosol is key anti-inflammatory compound in olive: DSM study - Nutra USA, 8/25/11 - "Hydroxytyrosol, an ingredient to watch, has been identified as the main anti-inflammatory compound in olives ... hydroxytyrosol was found to inhibit both nitric oxide (NO) and prostaglandin E2 (PGE2), both are pro-inflammatory compounds ... The effects of hydroxytyrosol on NO and chemokine production point to their impact on chronic inflammatory processes in endothelium or arthritis ... Hydroxytyrosol is thought to be the main antioxidant compound in olives, and believed to play a significant role in the many health benefits attributed to olive oil ... Data has also suggested the compound may boost eye health and reduce the risk of against macular degeneration ... Several companies already offer the compound for nutraceutical applications ... Results showed that hydroxytyrosol inhibited the production of both NO and PGE2 in mouse cells, "reflecting strong anti-inflammatory activity"" - [Abstract] - Note:  Trouble is, you usually don't want to inhibit nitric oxide.
  • Curry spice could offer treatment hope for tendinitis - Science Daily, 8/9/11 - "Tendons, the tough cords of fibrous connective tissue that join muscles to bones, are essential for movement because they transfer the force of muscle contraction to bones. However, they are prone to injury, particularly in athletes who may overstretch themselves and overuse their joints. Tendinitis (or tendonitis) is a form of tendon inflammation, which causes pain and tenderness near to joints and is particularly common in shoulders, elbows, knees, hips, heels or wrists. Other examples of common tendon disease include tennis and golfer's elbow and Achilles tendinitis ... introducing curcumin in the culture system inhibits NF-kB and prevents it from switching on and promoting further inflammation ... The results follow on from another study by the Nottingham-Munich collaboration, published in the Journal of Biological Chemistry earlier this year, demonstrating that a compound found in red wine could have therapeutic potential for osteoporosis related bone loss in elderly patients, post-menopausal women and patients with rheumatoid arthritis ... The research found that resveratrol, a naturally occurring phytoestrogen found in the skin of red grapes, vines and various other fruits and nuts, inhibits inflammation in bone cells. Its effects extended to inhibiting the formation of osteoclasts, giant congregations of blood-derived cells responsible for bone degeneration, especially in osteoporosis in later life. Resveratrol prevented NF-kB from switching on to trigger inflammation" - See resveratrol products at Amazon.com and curcumin products at Amazon.com.
  • Omega-3 reduces anxiety and inflammation in healthy students, study suggests - Science Daily, 7/13/11 - "A new study gauging the impact of consuming more fish oil showed a marked reduction both in inflammation and, surprisingly, in anxiety among a cohort of healthy young people ... The supplement was probably about four or five times the amount of fish oil you'd get from a daily serving of salmon ... But the psychological surveys clearly showed an important change in anxiety among the students: Those receiving the omega-3 showed a 20 percent reduction in anxiety compared to the placebo group ... We saw a 14 percent reduction in the amounts of IL-6 among the students receiving the omega-3." Since the cytokines foster inflammation, "anything we can do to reduce cytokines is a big plus in dealing with the overall health of people at risk for many diseases,"" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models - Atherosclerosis. 2011 May 5 - "In cultured human endothelial cells, quercetin protected against H(2)O(2)-induced lipid peroxidation and reduced the cytokine-induced cell-surface expression of VCAM-1 and E-selectin. Quercetin also reduced the transcriptional activity of NFκB in human hepatocytes. In human CRP transgenic mice (quercetin plasma concentration: 12.9+/-1.3μM), quercetin quenched IL1β-induced CRP expression, as did sodium salicylate. In ApoE*3Leiden mice, quercetin (plasma concentration: 19.3+/-8.3μM) significantly attenuated atherosclerosis by 40% (sodium salicylate by 86%). Quercetin did not affect atherogenic plasma lipids or lipoproteins but it significantly lowered the circulating inflammatory risk factors SAA and fibrinogen. Combined histological and microarray analysis of aortas revealed that quercetin affected vascular cell proliferation thereby reducing atherosclerotic lesion growth. Quercetin also reduced the gene expression of specific factors implicated in local vascular inflammation including IL-1R, Ccl8, IKK, and STAT3 ...Quercetin reduces the expression of human CRP and cardiovascular risk factors (SAA, fibrinogen) in mice in vivo. These systemic effects together with local anti-proliferative and anti-inflammatory effects in the aorta may contribute to the attenuation of atherosclerosis" - See quercetin at Amazon.com.
  • Consumption of polyunsaturated fatty acids, fish, and nuts and risk of inflammatory disease mortality - Am J Clin Nutr. 2011 Mar 16 - "Women in the highest tertiles of total n-3 PUFA intake, compared with those in the lowest tertile of intake at baseline, had a 44% reduced risk of inflammatory disease mortality (P for trend = 0.03). This association was not observed in men" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • A Dietary Mixture Containing Fish Oil, Resveratrol, Lycopene, Catechins, and Vitamins E and C Reduces Atherosclerosis in Transgenic Mice - J Nutr. 2011 Mar 16 - "Chronic inflammation and proatherogenic lipids are important risk factors of cardiovascular disease (CVD). Specific dietary constituents such as polyphenols and fish oils may improve cardiovascular risk factors and may have a beneficial effect on disease outcomes ... AIDM was evaluated in an inflammation model, male human C-reactive protein (CRP) transgenic mice, and an atherosclerosis model, female ApoE*3Leiden transgenic mice. Two groups of male human-CRP transgenic mice were fed AIDM [0.567% (wt:wt) powder and 0.933% (wt:wt oil)] or placebo for 6 wk. The effects of AIDM on basal and IL-1β-stimulated CRP expression were investigated. AIDM reduced cytokine-induced human CRP and fibrinogen expression in human-CRP transgenic mice. In the atherosclerosis study, 2 groups of female ApoE*3Leiden transgenic mice were fed an atherogenic diet supplemented with AIDM [0.567% (wt:wt) powder and 0.933% (wt:wt oil)] or placebo for 16 wk. AIDM strongly reduced plasma cholesterol, TG, and serum amyloid A concentrations compared with placebo. Importantly, long-term treatment of ApoE*3Leiden mice with AIDM markedly reduced the development of atherosclerosis by 96% compared with placebo. The effect on atherosclerosis was paralleled by a reduced expression of the vascular inflammation markers and adhesion molecules inter-cellular adhesion molecule-1 and E-selectin. Dietary supplementation of AIDM improves lipid and inflammatory risk factors of CVD and strongly reduces atherosclerotic lesion development in female transgenic mice" - See resveratrol products at Amazon.com, Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com, Jarrow Formulas, CarotenALL at Amazon.com, green tea extract at Amazon.com and Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • The ethanolamide metabolite of DHA, docosahexaenoylethanolamine, shows immunomodulating effects in mouse peritoneal and RAW264.7 macrophages: evidence for a new link between fish oil and inflammation - Br J Nutr. 2011 Feb 4:1-10 - "Among the compounds tested, docosahexaenoylethanolamine (DHEA), the ethanolamide of DHA, was found to be the most potent inhibitor, inducing a dose-dependent inhibition of NO release. Immune-modulating properties of DHEA were further studied in the same cell line, demonstrating that DHEA significantly suppressed the production of monocyte chemotactic protein-1 (MCP-1), a cytokine playing a pivotal role in chronic inflammation. In LPS-stimulated mouse peritoneal macrophages, DHEA also reduced MCP-1 and NO production. Furthermore, inhibition was also found to take place at a transcriptional level, as gene expression of MCP-1 and inducible NO synthase was inhibited by DHEA. To summarise, in the present study, we showed that DHEA, a DHA-derived NAE metabolite, modulates inflammation by reducing MCP-1 and NO production and expression. These results provide new leads in molecular mechanisms by which DHA can modulate inflammatory processes" - See Jarrow Max DHA at Amazon.com.
  • Effects of green tea catechins on the pro-inflammatory response after haemorrhage/resuscitation in rats - Br J Nutr. 2011 Feb 4:1-7 - "Plant polyphenols, i.e. green tea extract (GTE), possess high antioxidative and anti-inflammatory capacity, thus being protective in various models of acute inflammation ... Compared with both sham groups, inflammatory markers (serum IL-6 and hepatic PMNL infiltration) were elevated after H/R (P < 0.05). Also, H/R increased IκBα phosphorylation. GTE administration markedly (P < 0.05) decreased serum ALT and IL-6 levels, hepatic necrosis as well as PMNL infiltration and the expression of ICAM-1 and phosphorylated IκBα compared with H/R. In conclusion, we observed that NF-κB activation plays an important role in the pathogenesis of liver injury after H/R through the up-regulation of hepatic ICAM-1 expression and subsequent PMNL infiltration. GTE pre-treatment prevents liver damage in this model of acute inflammation through a NF-κB-dependent mechanism" - See green tea extract at Amazon.com.
  • Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice - Lipids Health Dis. 2010 Dec 16;9(1):143 - "The present results clearly demonstrate that alpha-, gamma-, or delta-tocotrienol treatments inhibit the chymotrypsin-like activity of 20S rabbit muscle proteasomes ... These results represent a novel approach by using natural products, such as tocotrienols as proteasome modulators, which may lead to the development of new dietary supplements of tocotrienols for cardiovascular diseases as well as others that are based on inflammation" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-{alpha}-mediated inflammation and insulin resistance in primary human adipocytes - Am J Clin Nutr. 2010 Oct 13 - "These data suggest that quercetin is equally or more effective than trans-RSV in attenuating TNF-α-mediated inflammation and insulin resistance in primary human adipocytes" - See quercetin at Amazon.com.
  • Resveratrol shows metabolic benefits for obese: Study - Nutra USA, 10/11/10 - "When human fat cells were exposed to IL-1B, the researchers noted increases in the secretion of pro-inflammatory compounds, including IL6, IL8, MCP-1. However, when the cells were simultaneously exposed to resveratrol, a 16 to 36 percent reduction in the expression of these cytokines was observed" - [Abstract] - See resveratrol products at Amazon.com.
  • Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants - Int J Obes (Lond). 2010 Jun 8 - "This study is the first to show anti-inflammatory effects of RSV on adipokine expression and secretion in human adipose tissue in vitro through the SIRT1 pathway. Thus, RSV is hypothesized to possess beneficial effects and might improve the metabolic profile in human obesity" - See resveratrol products at Amazon.com.
  • Sulphoraphane inhibited the expressions of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 through MyD88-dependent toll-like receptor-4 pathway in cultured endothelial cells - Nutr Metab Cardiovasc Dis. 2010 Sep 27 - "Chronic inflammation plays pivotal roles in both cancer and cardiovascular diseases. A large body of evidence suggests that high intake of cruciferous vegetables is closely related with low risk of these disorders ... Taken all together, adhesion molecules are confirmed to be the novel targets of sulphoraphane in preventing inflammatory insult to endothelial cells. Sulphoraphane suppressed TLR-4 followed by MyD88 and downstream factors such as p38 MAPK and JNK, ultimately blocking NF-кB translocation and the subsequent expression of adhesion molecules. These data suggested a novel inflammatory pathway mediated by sulphoraphane" - See sulforaphane at Amazon.com.
  • Inhibition of microsomal prostaglandin E(2) synthase-1 as a molecular basis for the anti-inflammatory actions of boswellic acids from frankincense - Br J Pharmacol. 2010 Sep 14 - "BAs reversibly suppressed the transformation of prostaglandin (PG)H(2) to PGE(2) mediated by mPGES1 (IC(50) = 3-10 µM). Also in intact A549 cells, BAs selectively inhibited PGE(2) generation and, in human whole blood, β-BA reduced lipopolysaccharide-induced PGE(2) biosynthesis without affecting formation of the COX-derived metabolites 6-keto PGF(1α) and thromboxane B(2) . Intraperitoneal or oral administration of β-BA (1 mg kg(-1) ) suppressed rat pleurisy, accompanied by impaired levels of PGE(2) ,.and β-BA (1 mg kg(-1) , given i.p.) also reduced mouse paw oedema, both induced by carrageenan. Conclusions and implications: Suppression of PGE(2) formation by BAs via interference with mPGES1 contributed to the anti-inflammatory effectiveness of BAs and of frankincense, and may constitute a biochemical basis for their anti-inflammatory properties" - See boswellia at Amazon.com.
  • Why fish oils work swimmingly against inflammation and diabetes - Science Daily, 9/2/10 - "Researchers at the University of California, San Diego School of Medicine have identified the molecular mechanism that makes omega-3 fatty acids so effective in reducing chronic inflammation and insulin resistance ... omega-3 fatty acids activate this macrophage receptor, resulting in broad anti-inflammatory effects and improved systemic insulin sensitivity ... It's just an incredibly potent effect ... omega-3 fatty acids switch on the receptor, killing the inflammatory response" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Resveratrol differentially modulates inflammatory responses of microglia and astrocytes - J Neuroinflammation. 2010 Aug 17;7(1):46 - "These results suggest that murine microglia and astrocytes produce proinflammatory cytokines and NO in response to LPS in a similar pattern with some differences in signaling molecules involved, and further suggest that resveratrol exerts anti-inflammatory effects in microglia and astrocytes by inhibiting different proinflammatory cytokines and key signaling molecules" - See resveratrol products at Amazon.com.
  • Resveratrol’s anti-inflammatory power gets human data boost - Nutra USA, 8/3/10 - "The results demonstrated in the research are the first time that such findings have been seen in humans, but are consistent with potential antiatherogenic and antiaging effects of resvertatrol. Concluding that PCE “has a comprehensive suppressive effect on oxidative and inflammatory stress.”" -[Abstract] - See resveratrol products at Amazon.com.
  • An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol - J Clin Endocrinol Metab. 2010 Jun 9 - "The extract induced a significant reduction in reactive oxygen species generation, the expression of p47(phox), intranuclear nuclear factor-kappaB binding, and the expression of jun-N-terminal kinase-1, inhibitor of kappaB-kinase-beta, phosphotyrosine phosphatase-1B, and suppressor of cytokine signaling-3 in mononuclear cells when compared with the baseline and the placebo. PCE intake also suppressed plasma concentrations of TNF-alpha, IL-6, and C-reactive protein. There was no change in these indices in the control group given placebo. Conclusions: The PCE-containing resveratrol has a comprehensive suppressive effect on oxidative and inflammatory stress" - See resveratrol products at Amazon.com.
  • Plant compound resveratrol shown to suppresses inflammation, free radicals in humans - Science Daily, 7/29/10 - "Resveratrol, a popular plant extract shown to prolong life in yeast and lower animals due to its anti-inflammatory and antioxidant properties, appears also to suppress inflammation in humans ... resveratrol has been shown to prolong life and to reduce the rate of aging in yeast, roundworms and fruit flies, actions thought to be affected by increased expression of a particular gene associated with longevity ... The compound also is thought to play a role in insulin resistance as well, a condition related to oxidative stress, which has a significant detrimental effect on overall health ... resveratrol suppressed the generation of free radicals, or reactive oxygen species, unstable molecules known to cause oxidative stress and release proinflammatory factors into the blood stream, resulting in damage to the blood vessel lining ... Blood samples from persons taking resveratrol also showed suppression of the inflammatory protein tumor necrosis factor (TNF) and other similar compounds that increase inflammation in blood vessels and interfere with insulin action, causing insulin resistance and the risk of developing diabetes" - See resveratrol products at Amazon.com.
  • Cutting fat and calories can lower cancer risk in dogs and people - Science Daily, 7/22/10 - "As many as 1 out of 3 cancer deaths in both humans and dogs could be prevented by reducing Omega-6 fatty acids and cutting calories ... Omega-6, such as corn oil, vegetable oil and grain-fed red meat. Too much Omega-6 fatty acid can lead to inflammation, which creates an environment conducive to cancer in dogs and people ... obesity in both dogs and humans limits the production of adiponectin, a hormone that has been shown to inhibit cancer cell growth. He recommended reducing calories, particularly those from sugar, which has the additional danger of not only causing obesity, but also feeding cancer cells and encouraging their growth ... the ideal blend of fiber for dog food is about 75 to 80 percent insoluble and 20 to 25 percent soluble. In addition, adding quality prebiotics to pet foods can enhance their gut health"
  • Natural substance NT-020 aids aging brains in rats, study finds - Science Daily, 7/20/10 - "Aging has been linked to oxidative stress, and we have previously shown that natural compounds made from blueberries, green tea, and amino acids, such as carnosine, are high in antioxidants and have anti-inflammatory and anti-oxidative activity .... The combination of these nutrients, called NT-020, creates a synergistic effect that promotes the proliferation of stem cells in the aged animals ... NT-020 may have not only a positive effect on the stem cell niche ... NT-020 may have far-reaching effects on organ function beyond the replacement of injured cells, as demonstrated by cognitive improvement in the NT-020 group"
  • Progesterone Leads To Inflammation, Scientists Find - Science Daily, 8/19/09 - "Exposure to progesterone in normal amounts and in normal circumstances causes inflammation, which promotes breast development ... exposure to progesterone in menopausal hormone therapy is known to increase breast cancer risk"
  • Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity - Diabet Med. 2009 May;26(5):526-31 - "GSE significantly improved markers of inflammation and glycaemia and a sole marker of oxidative stress in obese Type 2 diabetic subjects at high risk of cardiovascular events over a 4-week period, which suggests it may have a therapeutic role in decreasing cardiovascular risk" - See grape seed extract at Amazon.com.
  • Scientists Uncork Potential Secret Of Red Wine's Health Benefits - Science Daily, 7/30/09 - "researchers administered an inflammatory agent to two groups of mice. One group was pretreated with resveratrol and the other group was not. The mice that were not pretreated with resveratrol experienced a strong inflammatory response, simulating disease in humans, while the group pretreated with resveratrol was protected from the inflammation. The scientists then examined the tissues of the mice to determine exactly how resveratrol was able to protect the mice from inflammation. They found that resveratrol used a one-two punch to stop inflammation in the mice by preventing the body from creating two different molecules known to trigger inflammation, sphingosine kinase and phospholipase D. This finding suggests that resveratrol may be harnessable as a treatment for inflammatory diseases and may also lead to entirely new resveratrol-based drugs that are even more effective" - See resveratrol products at Amazon.com.
  • Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity - Acta Cardiol. 2009 Jun;64(3):321-7 - "were given 1 gram of fish oil as a single capsule, containing 180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid daily for 6 months. Control subjects did not receive any supplementation over the same period. RESULTS: The study was completed by 47 subjects in the intervention group and 42 subjects in the control group. Treatment with omega 3 supplements was associated with a significant fall in body weight (P < 0.05), systolic blood pressures (P < 0.05), serum low density lipoprotein cholesterol (P < 0.05), and total cholesterol (P < 0.05), triglycerides (P < 0.05), high-sensitivity C-reactive protein (hs-CRP) (P < 0.01), and Hsp27 antibody titres (P < 0.05). No significant changes were observed in the control group. CONCLUSION: It appears that omega 3 improves the cardiovascular risk profile of subjects with metabolic syndrome, having effects on weight, systolic blood pressure, lipid profile and markers of inflammation and autoimmunity" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells - Am J Clin Nutr. 2009 Jun 10 - "A high EPA+DHA intake changed the expression of 1040 genes, whereas HOSF intake changed the expression of only 298 genes. EPA+DHA intake resulted in a decreased expression of genes involved in inflammatory- and atherogenic-related pathways, such as nuclear transcription factor kappaB signaling, eicosanoid synthesis, scavenger receptor activity, adipogenesis, and hypoxia signaling. CONCLUSION: These results are the first to show that intake of EPA+DHA for 26 wk can alter the gene expression profiles of PBMCs to a more antiinflammatory and antiatherogenic status" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Omega Fatty Acid Balance Can Alter Immunity And Gene Expression - Science Daily, 5/29/09 - "Anthropological evidence suggests that human ancestors maintained a 2:1 w6/w3 ratio for much of history, but in Western countries today the ratio has spiked to as high as 10:1. Since these omega fatty acids can be converted into inflammatory molecules, this dietary change is believed to also disrupt the proper balance of pro- and anti- inflammatory agents, resulting in increased systemic inflammation and a higher incidence of problems including asthma, allergies, diabetes, and arthritis ... many key signaling genes that promote inflammation were markedly reduced compared to a normal diet, including a signaling gene for a protein called PI3K, a critical early step in autoimmune and allergic inflammation responses" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Associations of dietary long-chain n-3 polyunsaturated fatty acids and fish with biomarkers of inflammation and endothelial activation (from the Multi-Ethnic Study of Atherosclerosis [MESA]) - Am J Cardiol. 2009 May 1;103(9):1238-43 - "Long-chain n-3 PUFA intake was inversely associated with plasma concentrations of interleukin-6 (p = 0.01) and matrix metalloproteinase-3 (p = 0.03) independent of age, body mass index, physical activity, smoking, alcohol consumption, and dietary variables. Nonfried fish consumption was inversely related to C-reactive protein (p = 0.045) and interleukin-6 (p <0.01) ... the results of this study suggest that the dietary intake of long-chain n-3 PUFAs and fish is inversely associated with concentrations of some biomarkers, reflecting lower levels of inflammation and endothelial activation. These results may partially explain the cardioprotective effects of fish consumption" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Vitamin D Deficiency Related To Increased Inflammation In Healthy Women - Science Daily, 4/8/09 - "75 percent of Americans do not get enough Vitamin D. Researchers have found that the deficiency may negatively impact immune function and cardiovascular health and increase cancer risk. Now, a University of Missouri nutritional sciences researcher has found that vitamin D deficiency is associated with inflammation, a negative response of the immune system, in healthy women ... This may explain the vitamin's role in the prevention and treatment of inflammatory diseases, including heart disease, multiple sclerosis and rheumatoid arthritis ... To improve vitamin D status and achieve its related health benefits, most people should get at least 1000 IU of vitamin D per day" - See vitamin D at Amazon.com.
  • New Therapy Protects Lungs From Runaway Inflammation - Science Daily, 3/11/09
  • DHA Supplementation Decreases Serum C-Reactive Protein and Other Markers of Inflammation in Hypertriglyceridemic Men - J Nutr. 2009 Jan 21 - "DHA supplementation for 45 and 91 d decreased the number of circulating neutrophils by 11.7 and 10.5%, respectively (P < 0.05). It did not alter the circulating concentrations of other inflammatory markers tested within 45 d, but at 91 d it reduced (P < 0.05) concentrations of C-reactive protein (CRP) by 15%, interleukin-6 by 23%, and granulocyte monocyte-colony stimulating factor by 21% and DHA increased the concentration of antiinflammatory matrix metalloproteinase-2 by 7%. The number of circulating neutrophils was positively associated with the weight percent (wt %) of 20:4(n-6) in RBC lipids, and negatively to the wt % of 20:5(n-3) and 22:6(n-3). Concentrations of CRP and serum amyloid A were positively associated with the sum of SFA and negatively with the wt % of 18:1(n-9) and 17:0 in RBC lipids; CRP was also positively associated with the wt % of 20:2(n-6). The mean size of VLDL particles was positively associated with plasma concentrations of neutrophils and CRP. In conclusion, DHA may lessen the inflammatory response by altering blood lipids and their fatty acid composition" - See Jarrow Max DHA at Amazon.com.
  • Pine bark extract may help joints and hearts: Study - Nutra USA, 12/11/08 - "The decrease of systemic inflammatory markers, particularly CRP, suggests Pycnogenol properties may be potent enough to arrest the spread of inflammation from osteoarthritic joints to the whole organisms ... subjects received either two daily doses of 50 mg Pycnogenol or placebo for three months ... people receiving the pine bark extract experienced significant reductions in CRP levels from an average of 3.9 mg/L at the start of the study to 1.1 mg/L after three months. This is equivalent to a 71 per cent reduction ... Moreover, a reduction in the blood levels of reactive oxygen species (ROS) of 30 per cent was recorded" - See Pycnogenol at Amazon.com.
  • Vitamin E Shows Possible Promise In Easing Chronic Inflammation - Science Daily, 12/4/08 - "the larger take-home message of the study, published in the December issue of the journal Experimental Physiology, is that Vitamin E “may be beneficial in individuals with chronic inflammation, such as the elderly or patients with type II diabetes or chronic heart failure" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals - Atherosclerosis. 2008 Sep 27 - "The combination of n-3 PUFA and plant sterols reduced several inflammatory markers. High sensitivity C-reactive protein (hs-CRP) was reduced by 39% (P=0.009), tumor necrosis factor-alpha (TNF-alpha) by 10% (P=0.02), interleukin-6 (IL-6) by 10.7% (P=0.009), leukotriene B(4) (LTB(4)) by 29.5% (P=0.01) and adiponectin was increased by 29.5% (P=0.05). Overall cardiovascular risk was reduced by 22.6% (P=0.006) in the combination group. CONCLUSION: We have demonstrated, for the first time that dietary intervention with n-3 PUFA and plant sterols reduces systemic inflammation in hyperlipidemic individuals. Furthermore, our results suggest that reducing inflammation provides a potential mechanism by which the combination of n-3 PUFA and plant sterols are cardioprotective" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Loss Of Sleep, Even For A Single Night, Increases Inflammation In The Body - Science Daily, 9/2/08 - "losing sleep for even part of one night can trigger the key cellular pathway that produces tissue-damaging inflammation. The findings suggest a good night’s sleep can ease the risk of both heart disease and autoimmune disorders such as rheumatoid arthritis"
  • Common Cooking Spice Found In Curry Shows Promise In Combating Diabetes And Obesity - Science Daily, 6/20/08 - "turmeric-treated mice were less susceptible to developing Type 2 diabetes, based on their blood glucose levels, and glucose and insulin tolerance tests. They also discovered that turmeric-fed obese mice showed significantly reduced inflammation in fat tissue and liver compared to controls. They speculate that curcumin, the anti-inflammatory, anti-oxidant ingredient in turmeric, lessens insulin resistance and prevents Type 2 diabetes in these mouse models by dampening the inflammatory response provoked by obesity" - See curcumin products at Amazon.com.
  • Failure To Bridle Inflammation Spurs Atherosclerosis - Science Daily, 6/18/08 - "When a person develops a sore or a boil, it erupts, drawing to it immune system cells that fight the infection. Then it resolves and flattens into the skin, often leaving behind a mark or a scar ... A similar scenario plays out in the blood vessels. However, when there is a defect in the resolution response -- the ability of blood vessels to recover from inflammation -- atherosclerosis or hardening of the arteries can result ... Some natural mediators that 'cool' this inflammation are derived from omega-3 polyunsaturated fatty acids" - See Mega Twin EPA at Amazon.com.
  • Pomegranate extract may stop inflammation, says Bugs - Nutra USA, 6/13/08 - "COX-1 and COX-2 activity was significantly reduced in the pomegranate-fed animals, compared to control, particularly for COX-2. Indeed, COX-1 activity was reduced by about seven per cent following ingestion of the extract, while COX-2 activity decreased by about 26 per cent" - [Science Daily] - See pomegranate at Amazon.com.
  • Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1 - Proc Natl Acad Sci U S A. 2008 May 19 - "Luteolin consumption reduced LPS-induced IL-6 in plasma 4 h after injection. Furthermore, luteolin decreased the induction of IL-6 mRNA by LPS in hippocampus but not in the cortex or cerebellum. Taken together, these data suggest luteolin inhibits LPS-induced IL-6 production in the brain by inhibiting the JNK signaling pathway and activation of AP-1 in microglia. Thus, luteolin may be useful for mitigating neuroinflammation" - See luteolin products at iHerb.
  • What Else May Probiotics Do In Adults? - Science Daily, 5/20/08 - "It was found that probiotics have an anti-inflammatory potential seen as a decrease in serum CRP levels and as a reduction in bacteria-induced production of proinflammatory cytokines in peripheral blood mononuclear cells"
  • Plant Flavonoid In Celery And Green Peppers Found To Reduce Inflammatory Response In The Brain - Science Daily, 5/20/08 - "The new study looked at luteolin (LOO-tee-OH-lin), a plant flavonoid known to impede the inflammatory response in several types of cells outside the central nervous system ... Those cells that were also exposed to luteolin showed a significantly diminished inflammatory response. Jang showed that luteolin was shutting down production of a key cytokine in the inflammatory pathway, interleukin-6 (IL-6). The effects of luteolin exposure were dramatic, resulting in as much as a 90 percent drop in IL-6 production in the LPS-treated cells ... Inflammatory cytokines such as interleukin-6 are very well known to inhibit certain types of learning and memory that are under the control of the hippocampus, and the hippocampus is also very vulnerable to the insults of aging ... If you had the potential to decrease the production of inflammatory cytokines in the brain you could potentially limit the cognitive deficits that result" - See luteolin at Amazon.com.
  • Diets With High Omega-6:Omega-3 Ratios Enhance Risk for Depression, Inflammatory Disease - Medscape, 4/25/08 - "Whereas the early hunter-gatherers had a dietary omega-6:omega-3 ratio of 2:1 to 3:1, this ratio is now 15:1 to 17:1 in North America today ... It is believed that these dietary changes might be related to increases in inflammatory-related diseases, including depression and cardiovascular disease ... at higher levels of depressive symptoms, as the omega-6:omega-3 ratio increased, there was a marked increase in proinflammatory cytokine levels ... compared with the study participants who did not have syndromal depression, the 6 participants who had depression had significantly higher omega-6:omega-3 ratios and higher levels of proinflammatory cytokines" - See Mega Twin EPA at Amazon.com.
  • "Anti-Inflammatory" Diet Improves Postprandial Glucose, CV Health - Medscape, 1/23/08 - "Specific recommendations to improve postprandial glucose and triglycerides are as follows: ... Select high-fiber carbohydrates with low glycemic index, including vegetables, fruits, whole grains, legumes, and nuts ... At all 3 meals, consume lean protein"
  • Coffee consumption is associated with higher plasma adiponectin concentrations in women with and without type 2 diabetes: a prospective cohort study - Diabetes Care. 2007 Dec 10 - "High consumption of caffeine-containing coffee is associated with higher adiponectin and lower inflammatory marker concentrations"
  • Study gives vitamin K anti-inflammation boost - Nutra USA, 12/3/07 - "Limited in vitro data support the inverse association between vitamin K and interleukin-6, and this may influence the association between vitamin K and other cytokines, such as osteoprotegerin" - [Abstract] - See vitamin K at Amazon.com.
  • Vitamin K and Vitamin D Status: Associations with Inflammatory Markers in the Framingham Offspring Study - Am J Epidemiol. 2007 Nov 15 - "Vitamin K status, measured by plasma phylloquinone concentration and phylloquinone intake, was inversely associated with circulating inflammatory markers as a group and with several individual inflammatory biomarkers" - See vitamin K at Amazon.com.
  • Exercise May Play Role In Reducing Inflammation In Damaged Skin Tissue - Science Daily, 11/28/07 - "moderate exercise sped up how fast wounds heal in old mice ... the improved healing response “may be the result of an exercise-induced anti-inflammatory response in the wound.” ... Cytokines are molecules that signal and direct immune cells, such as macrophages, to the site of an infection ..."
  • Fitness Reduces Inflammation, Study Suggests - Science Daily, 7/6/07 - "the research “certainly suggests that fitness may be associated with a decrease in inflammation even independent of body fat and several things, and the mechanism may involve a parasympathetic anti-inflammatory reflex"
  • Diets With High Omega-6:Omega-3 Ratios Enhance Risk for Depression, Inflammatory Disease - Medscape, 4/26/07 - "Whereas the early hunter-gatherers had a dietary omega-6:omega-3 ratio of 2:1 to 3:1, this ratio is now 15:1 to 17:1 in North America today ... compared with the study participants who did not have syndromal depression, the 6 participants who had depression had significantly higher omega-6:omega-3 ratios and higher levels of proinflammatory cytokines"
  • Depressive Symptoms, omega-6:omega-3 Fatty Acids, and Inflammation in Older Adults - Psychosom Med. 2007 Mar 30 - "Diets with high n-6:n-3 PUFA ratios may enhance the risk for both depression and inflammatory diseases"
  • Soy Consumption, Markers of Inflammation, and Endothelial Function: A cross-over study in postmenopausal women with the metabolic syndrome - Diabetes Care. 2007 Apr;30(4):967-73 - "Short-term soy nut consumption reduced some markers of inflammation and increased plasma nitric oxide levels in postmenopausal women with the metabolic syndrome"
  • Natural Solutions for Inflammation - Dr. Murray's Natural Living, 5/23/06
  • Does Inflammation Cause Heart Disease? - Dr. Weil, 5/18/06
  • How to fight inflammation - MSNBC, 5/12/06 - "The intensity of this general inflammation can be measured by blood tests for markers like C-reactive protein (CRP), which is produced by the liver during periods of inflammation ... People with increased levels of CRP seem to have a greater risk of heart disease from damage to their blood vessels ... Chronic inflammation may also be connected to cancers of the esophagus, stomach, colon and liver"
  • MIT Research Links Cancer, Inflammatory Disease - Science Daily, 4/5/06 - "The studies uncovered a surprising link between inflammatory diseases and cancer that may change how these diseases are treated in the future"
  • Reducing inflammation is the key to a stronger ticker. Six practical steps - deliciouslivingmag.com, 2/06
  • Supplements to decrease inflammation - deliciouslivingmag.com, 2/06
  • Influencing Inflammation? - Dr. Weil, 11/3/05
  • Fish Help the Heart by Fighting Inflammation - WebMD, 7/5/05 - "compared with those who said they didn't eat fish, those who ate at least 10.5 ounces of fish per week had 33% lower C-reactive protein and 33% lower tumor necrosis factor-alpha (another indicator of inflammation) levels as well as much lower levels of other signs of inflammation"
  • Healthy Gums May Help Fight Alzheimer's - WebMD, 6/20/05 - "Brushing your teeth may be one of many ways to help keep your mind healthy and lower the risk of Alzheimer's disease"
  • Eating Oily Fish May Reduce Inflammation - Science Daily, 3/24/05 - "This research group recently identified a new class of aspirin-triggered bioactive lipids, called resolvins, the activity of which may in part explain the beneficial effects of omega-3 fatty acids"
  • The dangers of inflammation - Functional Foods & Nutraceuticals, 2/05
  • Effect of CLA supplementation on immune function in young healthy volunteers - Eur J Clin Nutr. 2005 Jan 12 - "CLA supplementation also decreased the levels of the proinflammatory cytokines, TNF-alpha and IL-1beta (P<0.05), but increased the levels of the anti-inflammatory cytokine, IL-10 ... This is the first study to show that CLA, a fatty acid naturally found in dairy and meat products, can beneficially affect immune function in healthy human volunteers" - See conjugated linoleic acid at Amazon.com.
  • Ease inflammation - Delicious Living, 11/04
  • Inflammation Syndrome a Red-Hot Topic - Natural Foods Merchandiser, 9/03 - "What are some of the key anti-inflammatory supplements? ... At the top of the list are omega-3 fish oils, gamma-linolenic acid (GLA, an omega-6 fat that behaves more like an omega-3) and vitamin E. Several studies have shown that natural vitamin E supplements lower CRP levels by 30 percent to 50 percent"
  • Fish Oil Supplementation Reduces Severity of Exercise-Induced Bronchoconstriction in Elite Athletes - Am J Respir Crit Care Med. 2003 Aug 6 - "These data suggest that dietary fish oil supplementation has a markedly protective effect in suppressing EIB in elite athletes and this may be attributed to their anti-inflammatory properties"
  • Habitual Dietary Intake of n-3 and n-6 Fatty Acids in Relation to Inflammatory Markers Among US Men and Women - Circulation. 2003 Jun 23 - "These results suggest that n-6 fatty acids do not inhibit the antiinflammatory effects of n-3 fatty acids and that the combination of both types of fatty acids is associated with the lowest levels of inflammation. The inhibition of inflammatory cytokines may be one possible mechanism for the observed beneficial effects of these fatty acids on chronic inflammatory-related diseases" - See Mega Twin EPA at Amazon.com.
  • Eating to Ease Inflammation? - Dr. Weil, 5/7/03
  • Anti-Inflammatory Diet Plus Fish Oil Effective for Rheumatoid Arthritis - New Hope Natural Media, 5/1/03 - "An anti-inflammatory diet and fish oil supplements are both helpful for people with rheumatoid arthritis (RA), but combining them has an even greater effect ... The anti-inflammatory diet improved joint pain, swelling, and overall ability to function by 14%, while the Western diet did not improve symptoms or functioning. Benefits were observed with the addition of fish oil, bringing total improvement to 17% in those eating a Western diet and 37% in those eating the anti-inflammatory diet. Furthermore, the need for anti-inflammatory medications was significantly reduced for those receiving fish oil on both diets, although the group eating the anti-inflammatory diet had greater medication reduction. Medication usage increased for those on the Western diet plus placebo"
  • Protecting Blood Vessels From Stress - WebMD, 1/15/02 - "vitamins can improve blood flow and prevent the long-term development of atherosclerosis -- or hardening of the arteries -- when given in combination with an amino acid known as L-arginine ... antioxidants might work together with L-arginine to prevent inflammation in the branch areas of blood vessels ... although antioxidants may not reverse or repair pre-existing damage within blood vessels, they may slow the long-term progression of atherosclerosis" - See iHerb l-arginine products.
  • Can Herbs Combat Inflammation? - Dr. Weil, 12/3/02 - "Take 400 to 600 milligrams of turmeric extracts (available in tablets or capsules) three times per day or as directed on the product label. Whole turmeric is more effective than isolated curcumin, its major constituent. Look for products standardized for 95% curcuminoids. Be patient: the full benefit takes two months to develop. Don’t use turmeric if you have gallstones or bile duct dysfunction"
  • Scientists Say Inflammation Even Worse For Heart Than Cholesterol - Intelihealth, 8/6/02
  • A Message from Dr. Cooper - Wellness Insider, 5/22/02 - "the higher the pulse pressure, the greater the risk of having an elevated CRP ... "the findings suggest that a wide pulse pressure is associated with higher levels of inflammation," and that inflammation is increasingly "being seen as a risk factor for adverse cardiovascular events." ... Several things are known to lower CRP, including aspirin, vitamin E, and statins (cholesterol lowering drugs). Unpublished data from The Cooper Institute has also shown that exercise lowers CRP ... Early data from the double-blind, placebo-controlled clinical trial of Cooper Complete multivitamins is also showing a reduction of CRP"
  • Active Life Keeps Brain Healthy - WebMD, 5/21/02 - "An active lifestyle -- even if begun only in middle age -- spurs brain-cell growth and lowers risk of Alzheimer's disease ... In another study published in the same issue of the Annals of Neurology, researchers find that a particular chemical in the blood may be linked to Alzheimer's and other dementing diseases ... The chemical is called hs-CRP. It is a sign of inflammation -- the body's protective response to injury or infection"
  • Omega-3 Fatty Acid Reduces Pro-Inflammatory Cytokines In Heart Transplant Patients - Doctor's Guide, 4/11/02 - "gave 25 stable heart transplant patients two capsules of omega-3 fatty acid daily - each capsule contained 500 mg of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) ... The results suggest that omega-3 fatty acid supplementation increased concentrations of the anti-inflammatory interleukin (IL)-10, from 119 to 268 pg/mL (p=0.00008). There were reductions in systemic levels of pro-inflammatory IL-12, from 473 to 376 pg/mL (p=0.001), and IL-6, from 695 to 569 pg/mL (p<0.0001)"
  • Soy Fights Pain - WebMD, 3/15/02
  • Weight Loss Eases Harmful Inflammation - WebMD, 2/4/02 - "They measured levels of a blood chemical called "C-reactive protein," or CRP. This chemical goes up when inflammation in the body rises. Then, 25 of the women were put on a weight-loss program ... On average, CRP levels fell by 32% after a weight loss of about 33 pounds over 14 months"
  • Chronic Inflammation, The Epidemic Disease of Aging - Life Extension Magazine, 1/02 - "Chronic inflammation inflicts devastating effects, especially as humans grow older. The pathological consequences of inflammation are fully documented in the medical literature. Regrettably, the dangers of systemic inflammation continue to be ignored, even though proven ways exist to reverse this process"
  • Inflammation and Heart Disease - Life Extension Magazine, 1/01
  • Diet and Exercise Alone Shown to Lower C-Reactive Protein - Doctor's Guide, 11/14/01 - "Hs-CRP, a marker of low level inflammation, has been found to be a strong predictor of myocardial infarction and stroke in men and women, as well as subsequent clinical events in patients following major cardiac events ... a structured program involving a low-fat, Mediterranean diet and a supervised, three-times weekly exercise program for three months ... Values of hs-CRP dropped 31 percent after the three months ... body fat was reduced by 5 percent ... exercise capacity improved 36 percent"
  • Robert Culp spies arthritis relief - USA Today, 7/20/01 - "MSM — sometimes called DMSO2 — is similar, but has an additional oxygen molecule and a few advantages over DMSO ... Unlike its parent, MSM does not produce a sweet, garlic-like odor in the user. While DMSO was used primarily as a topical lotion, its ability to permeate tissue also brought contaminants with it. Impure industrial-grade DMSO, not of a pharmceutical quality, became common. Although MSM is available in lotion form, it is more commonly taken orally ... The most common theory is that MSM relieves arthritic pain through anti-inflammatory processes, perhaps through stimulating the circulation of oxygen-rich blood ... Other experts theorize that DMSO and MSM may both owe their efficacy to rich organic sulfur compounds"
  • Vitamin E Works As Anti-Inflammatory Agent In Type II Diabetes - Doctor's Guide, 7/10/00
  • Scientists Discover How Aspirin Reduces Inflammation - Doctor's Guide, 11/4/98
  • Drug therapy of activated arthrosis. On the effectiveness of an enzyme mixture versus diclofenac - Medline, 1996 (I thought this study was interesting because it showed that Wobenzym® was as effective as diclofenac.  In another study, diclofenac was show to be as effective as Vioxx.  That said, it would make sense that Wobenzym should be as effective as Vioxx.)

Other News:

  • The Dietary Inflammatory Index Is Associated with Colorectal Cancer Risk in the Multiethnic Cohort - J Nutr. 2017 Feb 8. pii: jn242529 - "Among all participants, more-proinflammatory diets (highest quartile compared with lowest quartile) were associated with an increased risk of CRC (HR: 1.21"
  • Increased Inflammatory Potential of Diet is Associated with Increased Risk of Prostate Cancer in Iranian Men - Int J Vitam Nutr Res. 2017 Jan 27:1-8 - "dietary inflammatory index (DII) ... Multivariable-adjusted analyses revealed that men with higher DII score (>0.23) to be at higher risk of prostate cancer [odds ratio (OR) = 3.96; 95% CI =1.29-12.16, p-value = 0.02)] compared to men with lower DII scores"
  • Inflammatory potential of diet and risk for hepatocellular cancer in a case-control study from Italy - Br J Nutr. 2015 Nov 11:1-8 - "dietary inflammatory index (DII). The DII was computed on the basis of dietary intake assessed 2 years before the date of interview ... Participants in the highest tertile of DII scores (i.e. with a more pro-inflammatory diet) had a higher risk for HCC (ORtertile 3 v, 1 2.43"
  • Testosterone and Mortality - Medscape, 10/2/14 - "The reason as to why testosterone is lower in these men at greater risk of earlier death may be that the degree of activation of pro-inflammatory cytokines reflects the severity of disease burden. There is clear evidence that testosterone levels are suppressed as a result of conditions which lead to the systemic production of inflammatory cytokines, be it as a result of low grade or more marked forms of chronic inflammation. Common clinical conditions which induce chronic inflammatory states are obesity, atherosclerosis, diabetes, chronic obstructive pulmonary disease and inflammatory arthritides. Acute illness as a result of infection, inflammation, infarction and trauma including surgery leads to severe suppression of the hypothalamic–pituitary–testicular axis resulting in levels of testosterone as low as 2 nmol/l. The majority of the studies described in this review especially in those which involve older men distinctly demonstrate that low testosterone is a biomarker disease severity and increased risk of mortality"
  • How 'good cholesterol' stops inflammation - Science Daily, 12/9/13 - "To put it simply, high HDL levels in blood are an important protective factor against sustained inflammation"
  • Controlling triggers of age-related inflammation could extend 'healthspan' - Science Daily, 10/21/13 - "Inflammation is the common denominator of many chronic age-related diseases such as arthritis, gout, Alzheimer's, and diabetes ... inflammation can lead to serious loss of function throughout the body, reducing healthspan -- that portion of our lives spent relatively free of serious illness and disability ... immune sensor Nlrp3 inflammasome is a common trigger of this inflammation-driven loss of function that manifests itself in insulin-resistance, bone loss, frailty, and cognitive decline in aging ... inflammation is causally linked to functional decline in aging ... we've pinpointed Nlrp3 as the specific sensor that activates inflammation with age ... animals with lower Nlrp3 activation were protected from many age-related disorders such as dementia, bone loss, glucose intolerance, cataracts, and thymus degeneration. Functionally, the mice also performed better, were less frail, and ran for longer durations ... One of our long-term goals is to develop therapies or specific diets that could dampen the excessive inflammation process as a means to prevent chronic diseases"
  • Chronic inflammation in the brain leads the way to Alzheimer's disease - Science Daily, 7/2/12
  • Diabetes linked to cognitive impairment in older adults, study suggests - Science Daily, 11/8/11 - "in older patients with diabetes, two adhesion molecules -- sVCAM and sICAM -- cause inflammation in the brain, triggering a series of events that affect blood vessels and, eventually, cause brain tissue to atrophy. Importantly, they found that the gray matter in the brain's frontal and temporal regions -- responsible for such critical functions as decision-making, language, verbal memory and complex tasks -- is the area most affected by these events ... at the age of 65, the average person's brain shrinks about one percent a year, but in a diabetic patient, brain volume can be lowered by as much as 15 percent ... Diabetes develops when glucose builds up in the blood instead of entering the body's cells to be used as energy. Known as hyperglycemia, this condition often goes hand-in-hand with inflammation ... Once chronic inflammation sets in, blood vessels constrict, blood flow is reduced, and brain tissue is damaged"
  • Immune mechanism blocks inflammation generated by oxidative stress - Science Daily, 10/5/11 - "Conditions like atherosclerosis and age-related macular degeneration (AMD) -- the most common cause of blindness among the elderly in western societies -- are strongly linked to increased oxidative stress, the process in which proteins, lipids and DNA damaged by oxygen free radicals and related cellular waste accumulate, prompting an inflammatory response from the body's innate immune system that results in chronic disease ... when lipids (fats) in cell membranes degrade through oxidative stress, they produce a number of reactive products, including a compound called malondialdehyde (MDA), which in turn modifies other molecules to create novel oxidation-specific epitopes, the part of antigens that draws the attention and inflammatory response of the innate immune system"
  • Endothelial Dysfunction and Low-Grade Inflammation Are Associated With Greater Arterial Stiffness Over a 6-Year Period - Hypertension. 2011 Aug 22 - "Biomarkers of endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness. This provides evidence that arterial stiffening may be a mechanism through which endothelial dysfunction and low-grade inflammation lead to cardiovascular disease"
  • How inflammation can lead to cancer - Science Daily, 4/19/11 - "inflammation stimulates a rise in levels of a molecule called microRNA-155 (miR-155) ... This, in turn, causes a drop in levels of proteins involved in DNA repair, resulting in a higher rate of spontaneous gene mutations, which can lead to cancer ... It is believed that cancer is caused by an accumulation of mutations in cells of the body ... Our study suggests that miR-155, which is associated with inflammation, increases the mutation rate and might be a key player in inflammation-induced cancers generally"
  • Biophysicist targeting IL-6 to halt breast, prostate cancer - Science Daily, 4/19/11 - "There is an inherent connection between inflammation and cancer ... In the case of breast cancers, a medical review systematically tabulated IL-6 levels in various categories of cancer patients, all showing that IL-6 levels elevated up to 40-fold, especially in later stages, metastatic cases and recurrent cases ... The current research offers us an exciting new therapeutic paradigm: targeting tumor microenvironment and inhibiting tumor stem cell renewal, leading to a really effective way to overcome breast tumor drug resistance, inhibiting tumor metastasis and stopping tumor recurrence" - Note:  See the "Alternative News" section of my IL-6 page for ways to reduce IL-6.
  • Study links inflammation in brain to some memory decline - Science Daily, 4/13/11 - "adults with measureable levels of C reactive protein recalled fewer words and had smaller medial temporal lobes ... Scientists don't know if the inflammation indicated by the C reactive protein is the cause of the memory loss, if it reflects a response to some other disease process or if the two factors are unrelated. But if inflammation causes the cognitive decline, relatively simple treatments could help"
  • Inflammation behind heart valve disease, research suggests - Science Daily, 3/15/11 - "immune cells and a group of inflammatory substances called leukotrienes can be found in calcified heart valves. The most significant inflammation was seen in patients with the narrowest valves on ultrasound examination. The researchers have also shown in cell cultures that leukotrienes stimulate the calcification of heart valve cells ... There are similarities between atherosclerosis (calcification of the arteries) and aortic stenosis. However, lipid-lowering medicines known as statins which are capable of preventing atherosclerosis have proved ineffective in preventing calcification of the aortic valve ... anti-inflammatory medication could be a future treatment for aortic stenosis, and it would mean a lot to these patients, most of whom are elderly, if we could slow the disease to the extent that they do not need surgery" - See the "Alternative News" sections of my Inflammation page and my C-Reactive Protein page for ways to reduce it.
  • Poor sleep quality increases inflammation, community study finds - Science Daily, 11/14/10
  • Inflammation is associated with lower intelligence and premature death - Science Daily, 9/6/10 - "with low-grade inflammation performed more poorly on standardised intelligence tests, even after excluding those with signs of current illness. Inflammation also predicted an increased risk of premature death ... This suggests that even low levels of inflammation can have detrimental consequences for health and brain function ... it is the largest study to date to show that low-grade inflammation in young adulthood is associated with intelligence and mortality"
  • New link found between inflammation and cancer - Science Daily, 8/16/10
  • Statins May Soon Be Given to Those With Excess Inflammation - U.S. News, 12/17/09 - "The Food and Drug Administration is considering expanding the use of cholesterol-lowering statin Crestor to those who have increased levels of inflammation—but not high cholesterol ... 2.8 percent of folks in the Crestor group developed diabetes compared with 2.3 percent of those who took placebos ... Experts still can't explain why Crestor would increase the likelihood of diabetes, but other research suggests that the entire class of statin drugs appears to have this downside ... found a 13 percent increased risk in diabetes in the statin users ... 1.5 percent of the placebo takers had a heart attack or stroke compared with 0.72 percent of the statin takers"
  • Inflammation May Trigger Alzheimer's Disease - Science Daily, 7/8/09 - "Inflammation, which is part of the body's natural immune response, occurs when the body activates white blood cells and produces chemicals to fight infection and invading foreign substances ... We induced inflammation in mice and found that it turned off the LRP pump that lets amyloid beta protein exit the brain into the bloodstream. It also revved up an entrance pump that transports amyloid beta into the brain. Both of these actions would increase the amount of amyloid beta protein in the brain"
  • How Inflammatory Disease Causes Fatigue - Science Daily, 2/28/09 - "Chronic inflammatory diseases like rheumatoid arthritis, inflammatory bowel disease, psoriasis, and liver disease cause "sickness behaviors," including fatigue, malaise, and loss of social interest ... These findings suggest that people with chronic inflammatory diseases may benefit from treatments that limit monocyte access to the brain"
  • How Inflammatory Disease Causes Fatigue - Science Daily, 2/17/09
  • Inflammation May Be Link Between Extreme Sleep Durations And Poor Health - Science Daily, 2/7/09
  • Inflammation Directly Linked To Colon Cancer; Potential New Drug Targets Revealed - Science Daily, 2/2/09
  • Inflammation Worsens Danger Due To Atherosclerosis - Science Daily, 1/23/09 - "inflammation increases the risk of plaque rupture in atherosclerosis"
  • Inflammation Contributes To Colon Cancer - Science Daily, 1/22/09
  • Novel Approaches To Heart Disease And Inflammation - Science Daily, 9/30/08 - "the immune system's role in heart disease is a relatively recent finding, with the first inklings of its importance discovered in the early 1980s. Prior to that time, scientists believed that atherosclerosis, a blockage in the arteries and the underlying cause of most heart problems, was due to plaque formation caused solely by cholesterol buildup ... inflammatory T cells not only contributed to plaque formation, but they also played a key role in the rupture of the artery wall, which produces a heart attack"
  • Inflammation, ageing and cancer - Mech Ageing Dev. 2008 Jul 10 - "Inflammation is necessary to manage with damaging agents and is crucial for survival. But, in our opinion, the pro-inflammatory status of ageing might be one of the mechanisms which relate cancer to ageing. The most appropriate inflammatory genes have been selected to survive and to reproduce. Paradoxically, inflammatory age-related diseases (including cancer) are the marks of the same evolutionistic trait. Centenarians are characterized by a higher frequency of genetic markers associated with better control of inflammation. The reduced capacity of centenarians to mount inflammatory responses appears to exert a protective effect towards the development of those age-related pathologies having a strong inflammatory pathogenetic component, including cancer. All in all, centenarians seem to carry a genetic background with a peculiar resistance to cancer which is also an anti-inflammatory profile"
  • Link Between Inflammation, Cancer Confirmed - Science Daily, 6/2/08 - "Chronic inflammation of the intestine or stomach can damage DNA, increasing the risk of cancer ... Researchers have long known that inflammation produces cytokines (immune response chemicals that encourage cell proliferation and suppress cell death), which can lead to cancer"
  • Inflammatory Markers and Albuminuria Independently Predict Heart Failure - Medscape, 5/2/08 - "Interleukin (IL)-6, C-reactive protein, and macroalbuminuria are significant predictors of congestive heart failure, independent of obesity and other established risk factors"
  • Role of Inflammation in Initiation and Perpetuation of Atrial Fibrillation - Medscape, 11/19/07
  • Salary, Schooling, Inflammation Linked - WebMD. 11/19/07
  • UCSD Researchers Discover Inflammation, Not Obesity, Cause of Insulin Resistance - Doctor's Guide, 11/6/07 - "The research also proved that obesity without inflammation does not result in insulin resistance ... when an animal or a human being becomes obese, they develop steatosis, or increased fat in the liver. The steatosis leads to liver inflammation and hepatic insulin resistance"
  • Inflammation, Metabolic Syndrome, Erectile Dysfunction, and Coronary Artery Disease: Common Links - Eur Urol. 2007 Aug 13 - "Increased circulating levels of inflammatory and endothelial-prothrombotic compounds are related to the presence and severity of ED"
  • Inflammation May Play Role In Metastasis Of Prostate Cancer - Science Daily, 3/18/07 - "inflammation associated with the progression of tumors actually plays a key role in the metastasis of prostate cancer"
  • Strong Link Seen Between Depression, Inflammation - Clinical Psychiatry News, 6/06 - "depressed patients have elevated inflammatory markers—such as interleukin-6 and C-reactive protein. In fact, the levels of proinflammatory cytokines correlate with the severity of depressive symptoms in studies. In addition, administration of cytokine antagonists can effectively reverse depressive symptoms in patients"
  • White Blood Cell Count, Inflammation Linked to Cancer Deaths - Doctor's Guide, 1/24/06 - "those with a higher white blood cell count, a sign of inflammation, were more likely to die of cancer ... The study also suggests that aspirin may have a greater protective effect against cancer for those with high WBC"
  • Inflammation Markers Tied to Narrow, Blocked Arteries - Doctor's Guide, 1/23/06 - "Hardening of the arteries in the legs is strongly associated with biological markers of inflammation, which may be a warning sign of heart trouble"
  • Caloric Restriction Appears to Prevent Primary Aging in the Heart - Doctor's Guide, 1/12/06 - "Our hypothesis is that low-grade, chronic inflammation is mediating primary aging"
  • Inflammation Linked To Chronic Pain: Study - Science Daily, 12/7/05
  • Extra Weight May Age You Faster - WebMD, 5/25/05 - "inflammation burns out white blood cells faster, and the effort of replacing them wears down the telomeres"
  • Simple Blood Test May Help To Predict Cardiovascular Risk In Older Women - Science Daily, 3/31/05 - "Increasing evidence supports a role for inflammation in the development of atherosclerosis, thickening and hardening of the arteries ... Women in the fourth quartile (highest WBC) had a doubled risk for coronary heart disease death compared with women in the first quartile (lowest WBC) ... the WBC count was an independent predictor of coronary heart disease risk, comparable in magnitude to C-reactive protein (CRP)"
  • Metabolic Syndrome Associated with Cognitive Decline in Elderly Persons - Doctor's Guide, 11/9/04 - "persons with the metabolic syndrome (n = 1016) were 20 percent more likely to develop cognitive impairment ... Those with both metabolic syndrome and high inflammation (n = 348) were 66 percent more likely to have cognitive impairment than those without the metabolic syndrome"
  • Aspirin May Delay Prostate Cancer, Extend Life - WebMD, 10/4/04 - "evidence is mounting that prostate cancer may develop in areas with chronic inflammation"
  • Longevity May Have Roots In Childhood - Science Daily, 9/20/04 - "Infectious diseases cause chronic inflammation in the blood that, decades later, leads to heart attacks, strokes and cancers – the classic killers of old age"
  • UCSD Researchers Are First To Demonstrate Molecular Link Between Inflammation And Cancer - Science Daily, 8/6/04
  • Missing Link Ties Cancer to Chronic Infection - WebMD, 8/5/04 - "Infections provoke an immune response from the body. Part of this response is inflammation. Inflamed tissues swell, redden, and leak fluids full of chemical signals to the immune system"
  • Fast Food Breakfast Triggers Inflammation - WebMD, 4/19/04
  • The Secret Killer - Time Magazine Cover Story, 2/23/04 - "Inflammation is the body's first defense against infection, but when it goes awry, it can lead to heart attacks, colon cancer, Alzheimer's and a host of other diseases ... exercise more, eat better and floss"
  • Examining Inflammation - Physician's Weekly, 2/2/04
  • Blood test can warn of heart attack - USA Today, 10/22/03
  • Hormone Replacement Therapy Beneficial in Post-Menopausal Women with Rheumatoid Arthritis - Doctor's Guide, 8/14/03 - "Women with rheumatoid arthritis (RA) who are receiving hormone replacement therapy (HRT) show greater improvements in disease activity, inflammation, bone mineral density, and radiological progression than women not receiving HRT ... Treatment with HRT also led to better control of inflammation"
  • Inflammation May Affect Osteoarthritis - WebMD, 8/1/03
  • Depression in Obese Men Associated with Increased C-Reactive Protein - Doctor's Guide, 7/15/03
  • When Diet Doesn't Lower Cholesterol - WebMD, 7/7/03 - "Study participants whose CRP levels were originally below average saw dramatic reductions in cholesterol after 12 weeks on the DASH diet. Total cholesterol dropped by almost 9% and LDL, or bad cholesterol, dropped by almost 12%. In participants with higher than average CRP levels, total and LDL cholesterol levels dropped by just 3% each ... This is the first study to suggest that inflammation impacts the response to a traditional cholesterol lowering diet ... Several recent studies have shown that people who lost weight on high-protein, relatively high-fat diets lowered their cholesterol, suggesting that weight loss alone, no matter how it is achieved, plays a significant role in lowering cholesterol"
  • Inflammation Linked to Age-Related Maculopathy - Doctor's Guide, 6/11/03 - "2 physiological signs of systemic inflammation, high white blood cell (WBC) count and low serum albumin levels, were associated with long term incidence of lesions characteristic of ARM ... Specifically, higher WBC count at baseline was linked to 2 early signs of ARM, an increase in large retinal drusen and RPE depigmentation, as well as progression of ARM. Lower serum albumin was associated with a late sign of ARM, exudative macular degeneration"
  • Infection, Autoimmune Reaction, Inflammation Trigger Heart Attack - WebMD, 5/12/03
  • Effect of metformin and sulfonylurea on C-reactive protein level in well-controlled type 2 diabetics with metabolic syndrome - Endocrine 2003 Apr;20(3):215-8 - "CRP level was significantly lower in patients using metformin for blood glucose control compared with those using glibenclamide, 5.56 and 8.3 mg/L, respectively ... The data showed that metformin decreases the level of circulating CRP, a marker of inflammation, more than glibenclamide"
  • C-reactive protein is independently associated with fasting insulin in nondiabetic women - Arterioscler Thromb Vasc Biol 2003 Apr 1;23(4):650-5 - "increasing levels of CRP were associated with a stepwise gradient in odds for elevated fasting insulin among both lean and overweight women"
  • Estrogen Patch More Heart-Friendly Than Pills - WebMD, 4/15/03 - "the C-reactive protein increased to an average of almost twice their baseline levels when the women took oral estrogen replacement, but not when they were on the estrogen patch"
  • Birth Control Pill Linked to Heart Disease Protein - WebMD, 4/11/03 - "young women who took birth control pills had twice as much C-reactive protein in their blood as a similar group of women who did not use birth control pills ... It is possible that oral contraceptive use promotes inflammation"
  • C-Reactive Protein Linked to Stroke Risk - WebMD, 4/7/03
  • Aspirin May Protect Against Parkinson's Disease - Doctor's Guide, 4/4/03 - "Dr. Ross hypothesized that since inflammation is thought to play a role in the neurodegenerative process leading to Parkinson's disease, anti-inflammatory drugs such as aspirin may help slow the progression of the disease ... The study showed that there were 17.7 cases of Parkinson's per 10,000 person-years in the patients who never took aspirin or were taking it on one occasion, compared with 6.8 cases per 10,000 person-years in the men who were taking aspirin on both assessments ... No conclusion could be drawn regarding the use of other NSAIDs and Parkinson's, he said, because too few of the men reported taking the drugs" - See drugstore.com aspirinicon products.
  • Ezetimibe Plus Simvastatin Reduces C-Reactive Protein in Patients with High Cholesterol - Doctor's Guide, 4/4/03 - "C-reactive protein is considered an emerging risk factor and risk marker for coronary heart disease ... the levels of C-reactive protein were about halved when the pooled ezetimibe plus simvastatin results were compared with simvastatin alone. The combination produced about a 34.8% reduction compared to an 18.2% reduction if the statin was used as monotherapy"
  • Level Of C-Reactive Protein Tied To Abdominal Aortic Aneurysm Size - Doctor's Guide, 3/13/03
  • Statins/Beta Blockers Impact On Certain C-Reactive Protein Levels - Doctor's Guide, 1/29/03 - "Some 93% of the 89 patients who did not use beta-blockers and were in the highest CRP category and had exercise-induced ischaemia, compared with 42% among patients in the lower four categories. Similarly, 94% of the 67 patients who did not use statins and were in the highest CRP category had exercise-induced ischaemia, compared with 44% in the lower four categories"
  • CRP improves cardiovascular risk prediction in metabolic syndrome - American Hearth Association, 1/28/03
  • New Heart Disease Blood Test Discouraged - WebMD, 1/27/03 - "hs-CRP is most useful when a doctor is "sitting on the fence" while determining the right treatment strategy for a person with intermediate risk of heart disease. In those cases -- meaning someone who, based on cholesterol, blood pressure, smoking history, and weight, is believed to have about 10% to 20% increased risk for heart attack over the next 10 years -- an elevated hs-CRP could tip the scale toward more aggressive treatment"
  • Bad Boy in the Blood: CRP - WebMD, 1/15/03 - "CRP doesn't just mark risk. It contributes to plaque formation in the blood-vessel wall. It promotes cholesterol uptake ... The most dazzling observation has been that in postmenopausal women, even those with low cholesterol levels, CRP identifies a three-fold increased risk for coronary artery disease ... When they added CRP to these cells, they saw dramatic effects. The cells began to secrete a substance called PAI-1. Increased PAI-1 secretion predicts formation of blood clots and heart disease. It also predicts diabetes and the pre-diabetes condition known as metabolic disorder ... You can lower your CRP levels by doing the same things you would do to lower your cholesterol levels: lose weight, eat fewer calories and a very low fat diet, take the cholesterol-lowering drugs known as statins, and the natural form of vitamin E"
  • Finger Arthritis Predicts Heart Disease - WebMD, 1/15/03 - "Men with osteoarthritis (OA) in any finger joint were 40% more likely to die of heart disease than their counterparts without finger OA. ... While "hardening of the arteries" was once thought to result from a buildup of cholesterol, increasing evidence indicates that it's the result of some type of inflammation of blood vessels"
  • C-Reactive Protein as a Predictor for Incident Diabetes Mellitus Among Middle-aged Men - Archives of Internal Medicine, 1/13/03 - "Low-grade systemic inflammation is associated with an increased risk of type 2 diabetes mellitus in middle-aged men. Inflammation could be one mechanism by which known risk factors for diabetes mellitus, such as obesity, smoking, and hypertension, promote the development of diabetes mellitus"
  • Rheumatoid Arthritis Linked With Other Inflammatory Diseases In Study - Doctor's Guide, 12/11/02
  • Low-dose Periostat (Doxycycline) Shows Benefits in Patients with Heart Failure - Doctor's Guide, 11/20/02 - "At six-month follow-up, sub-antimicrobial dose doxycyline significantly reduced CRP levels by 45.8 percent compared to baseline values (p<0.05). The drug was also associated with a 33.5 percent reduction in interleukin-6 and a 50 percent reduction in metalloproteinase ... The findings are exciting, since research is now showing that CRP is both a key marker of inflammation leading to future acute coronary events, but also that CRP itself may contribute to the initiation and progression of atherosclerosis"
  • Study finds alcohol may lessen inflammation - USA Today, 11/17/02 - "alcohol exerted the greatest benefit in those with the highest levels of a chemical called C-reactive protein, CRP, which builds up when arteries become inflamed. Some researchers now believe that CRP itself may be a previously unrecognized cause of heart disease ... Although LDL has long been considered the best measure of heart attack risk, about half of people who have heart attacks don't have high cholesterol ... "I think this is a fundamental shift in our thinking about (artery) disease""
  • Simple Blood Test Predicts Heart Disease - WebMD, 11/13/02
  • Inflammation Triggers Heart Attacks - Intelihealth, 11/14/02
  • Periodontal Diseases Increase C-Reactive Protein In Haemodialysis Patients - Doctor's Guide, 11/7/02
  • Inflammation May Increase Stroke Risk In Men With Hypertension - Doctor's Guide, 11/1/02 - "The study found that men with systolic blood pressure (the top number in a blood pressure reading) at or above 140 millimeters of mercury (mm Hg) and elevated levels of inflammation-sensitive plasma proteins (ISP) were four times as likely to have a stroke as were men who had normal blood pressure and normal ISP levels. Moreover, the inflammatory proteins predicted stroke risk for 10 or more years."
  • Pain Relievers May Prevent Alzheimer's - WebMD, 9/23/02 - "previous studies have suggested that aspirin and other NSAIDs might protect against Alzheimer's disease by reducing inflammation in the brain"
  • C-Reactive Protein, IL-6 Levels Tied to Heart Disease in Postmenopausal Women - Doctor's Guide, 8/28/02 - "Baseline levels of the inflammatory biomarkers C-reactive protein (CRP) and interleukin-6 (IL-6) are independently associated with a two-fold increase in risk of healthy postmenopausal women developing coronary heart disease (CHD)"
  • Antibiotics Aid Heart Patients - WebMD, 8/19/02 - "A year later, those who received an antibiotic were 36% less likely to be rehospitalized for a heart attack or chest pain than those who took a placebo ... The question, Mendall says, is whether the antibiotics are working by fighting infection or inflammation in these patients"
  • Increased Inflammation May Play A Role In Vascular Dysfunction In Type 2 Diabetes - Doctor's Guide, 8/1/02
  • Ulcer-Causing Bacteria Linked to Stroke - WebMD, 7/8/02 - "H. pylori causes ulcers in the stomach ... those who had suffered a stroke from a blocked large artery had significantly higher levels of the more potent strains of the bacteria ... The study also found that levels of a substance known as C-reactive protein (CRP) that indicates inflammation within the body were also higher in the stroke groups. But patients with the potent strains of H. pylori had the highest CRP levels ... treating patients with H. pylori infection may be an easy way to reduce the risk of stroke"
  • New Test Predicts Sudden Death Risk - WebMD, 4/15/02 - "those who suffered sudden cardiac death had higher levels of a substance called C-reactive protein (CRP) ... CRP is released when blood vessels are inflamed ... the findings of this study show that the levels of CRP in the blood are even more telling than once thought ... we can intervene with lifestyle counseling and drugs like statins and aspirin"
  • Statin Drugs May Fight Alzheimer's, Too - WebMD, 4/9/02 - "Statins block the vasoconstrictive [blood-vessel narrowing] effect of the A-beta protein -- a critical protein involved in Alzheimer's disease ... These drugs appear to have anti-inflammatory properties, independent of their benefit in lowering cholesterol, that may help protect against dementia" - Note:  Red yeast rice is a non-prescription statin.
  • Combining Statin With Estrogen May Maximise Post-Menopausal Cardiovascular Benefits - Doctor's Guide, 4/5/02 - "Oral estrogen alone increased the median level of C-reactive protein from 0.27 to 0.46 mg/dL, equivalent to a 70 percent rise. On the other hand, simvastatin decreased C-reactive protein levels from 0.29 to 0.28 mg/dL. Oral estrogen combined with simvastatin increased C-reactive protein levels by 29 percent from 0.28 to 0.36 mg/dL" - Note:  Red yeast rice is a non-prescription statin.
  • Lipitor (Atorvastatin Calcium) Reduces C-Reactive Protein In Acute Coronary Syndrome - Doctor's Guide, 3/19/02
  • Statins May Preserve Brain Power - WebMD, 3/18/02 - "The study also found that statin use was associated with a lower risk of memory problems or dementia, regardless of total cholesterol level. The authors say more research is needed to understand exactly how statins seem to protect the brain, but they suspect that the drugs may work by improving muscle function and reducing inflammation"
  • Scientists Examine Long-Term Risks And Gains Of Painkillers - Intelihealth, 1/22/02 - "The studies reflect scientists' growing interest in the idea that a common condition, inflammation, may underlie many chronic and debilitating diseases - like Alzheimer's, heart disease, osteoporosis and diabetes - and that drugs that fight inflammation may have a role in preventing or delaying those diseases, or at least slowing them down ... Originally, the effect was attributed to aspirin's ability to prevent blood clots, which can cause heart attacks or strokes. But now, researchers think part of the protective effect may come from aspirin's ability to quell inflammation in the arteries, helping to prevent blockages"
  • Statin Treatment In Coronary Heart Disease Lowers Levels Of Marker C-Reactive Protein - Doctor's Guide, 11/29/01
  • C-Reactive Protein Levels Indicative of Ischemic Risk in Some Men - Doctor's Guide, 11/12/01
  • Studies Bolster Inflammation-Heart Disease Link; May Prove Better Predictor Than Cholesterol - Intelihealth, 11/6/01
  • Inflammation May Contribute to Pre-eclampsia - Doctor's Guide, 10/3/01
  • Insulin Produces Anti-Inflammatory Effect On Vessel Walls - Doctor's Guide, 8/9/01
  • Another Study Suggests Inflammation May Trigger Diabetes - WebMD, 7/17/01 - "The immune system and inflammation may be factors causing type 2 diabetes ... women who had high levels of immune system substances called C-reactive protein or interleukin-6, or both, in their blood were more likely to develop type 2 diabetes ... Both C-reactive protein, called CRP, and interleukin-6, or IL-6, are considered indicators for inflammation"
  • Cholesterol drug has wider benefit - USA Today, 6/28/01 - [in addition to lowering cholesterol] "Cholesterol-lowering drugs, called statins, apparently work by reducing levels of a chemical known as C-reactive protein. This protein causes inflammation, promotes blood clotting and weakens fat-encased blockages inside arteries, causing them to burst"
  • Blood Test Could Indicate Who Might Benefit From Cholesterol-Lowering Drugs - Intelihealth, 6/27/01 - "Half of all heart attack patients have normal cholesterol levels. A blood test can detect high levels of C-reactive protein - a sign of inflammation"
  • Brushing your teeth may be good for your ticker - Scientific America, 5/01 - "Acute periodontitis may lead to heart disease because it might cause low-level inflammation in the whole body: chemicals produced by the immune reaction in the gum pockets probably spill over into the bloodstream and trigger the liver to make proteins that inflame arterial walls and clot blood. Atherosclerosis and, ultimately, heart attack may result. One such factor, C-reactive protein—a predictor of heart disease—is elevated in patients with periodontitis. Alternatively, the microbes themselves may travel from the mouth and affect blood vessels"
  • Antibiotics Reduce Inflammation In Heart Disease, Effect On Heart Attacks Unproven - Doctor's Guide, 3/29/99
  • New Agents May Provide Relief From Inflammation And Pain - Doctor's Guide, 3/4/98
  • Alzheimer's Disease Directly Linked To Inflammation -- Animal Study - Doctor's Guide, 7/22/97
  • Link Shown Between Inflammation and Heart Attack - Doctor's Guide, 4/2/97
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