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Anti-aging Research >
Antidepressants > SAM-e
News & Research:
Nutrient supplements can give antidepressants a boost - Science Daily,
4/26/16 - "Omega 3 fish oils, S-adenosylmethionine (SAMe),
methylfolate (bioactive form of folate) and Vitamin D, were all found to
boost the effects of medication ... They reported mixed results for zinc,
vitamin C and tryptophan (an amino acid). Folic acid didn't work
particularly well, nor did inositol" - Note: For people who want an
increase in energy and mood with anti-aging effects to boot, I’d skip the
antidepressants and go with a combination of
deprenyl, lithium (the over-the-counter
supplement form), GH-3 and
beta-arginine. On the beta-arginine, it will weird
you out if you don’t start slow and take it with food if possible. Build
yourself up to 3200 mg per day. Don’t take more than 800 mg per three
or four hour period. Check with a doctor first on all of that.
Also, see methylfolate at Amazon.com.
Adding Nutritional Supplement to Antidepressant Therapy May Boost Response
in Refractory Depression - Medscape, 8/18/10 -
"significantly more SAMe-treated than placebo-treated patients (36.1% vs
17.6%) experienced a clinical response on the 17-item Hamilton Depression
Rating Scale (HAM-D), which was the primary study outcome. Remission rates
(ie, HAM-D score of ≤7) were also higher with SAMe than with placebo (25.8%
Nutritional Supplement, SAMe, Effective In Preventing Formation Of Primary
Liver Cancer In Rats - Science Daily, 7/30/09 -
"A new study investigated the effectiveness of S-adenosylmethionine (SAMe)
in the prevention and treatment of hepatocellular carcinoma (HCC) or primary
liver cancer. SAMe, a widely available nutritional supplement, with little
known side effects, was found to be effective in preventing the formation of
HCC in rats" - [Abstract]
Can SAM-e Hurt My Heart? - Dr. Weil, 10/10/08 -
"Since SAM-e is ultimately converted in the body to homocysteine, it is
theoretically possible that taking it could elevate homocysteine levels. But
that doesn't happen. In fact, SAM-e actually appears to lower homocysteine
by helping the body metabolize it"
SAMe review - ConsumerLab.com, 4/26/07
Report: Same - Life Extension Magazine, 4/07
Improvement of aggressive behavior and quality of life impairment following
S-Adenosyl-Methionine (SAM-e) augmentation in schizophrenia - Eur
Neuropsychopharmacol. 2008 Sep 26 - "Eighteen
patients with chronic schizophrenia were randomly assigned to receive either
SAM-e (800 mg) or placebo for 8 weeks in double-blind fashion. Results
indicated some reduction in aggressive behavior and improved quality of life
following SAM-e administration. Female patients showed improvement of
natural pain relievers - MSNBC, 9/14/08 -
"Capsaicin: For arthritis, shingles, or neuropathy ... InflaThera or
Zyflamend: For arthritis ... Aquamin: For osteoarthritis ... SAM-e (S
adenosylmethionine): For osteoarthritis ... Fish oil: For joint pain from
arthritis or autoimmune disorders ... Methylsulfonyl-methane (MSM): For
Patients Seek Natural Alternatives to NSAIDs - Clinical Psychiatry News,
7/05 - "SAMe appeared to be as effective as NSAIDs
in reducing pain and improving functionality with fewer adverse effects than
SAMe - A Natural Compound that Offers Safe, Effective Relief from
Depression, Osteoarthritis, and Liver Disease - Life Extension Magazine,
1/05 - "SAMe offers arthritis relief without the
side effects associated with NSAIDs. Given its safety and tolerability
record, SAMe supplementation is recommended for anyone interested in
maintaining optimal liver function. Finally, SAMe is a valuable and
effective tool for managing depression, offering a safe, effective
alternative to prescription medications"
- SAMe Bioavailability
and Lack of Toxicity in Humans - Medscape, 12/16/04
Small Study Shows SAMe May Improve Treatment Of Depression - Science
- Dietary Supplement
Ups Antidepressant Effect - WebMD, 12/2/04 -
"Half the patients in the study reported significant improvement in symptoms
when they took SAMe along with their prescription antidepressant for six
weeks. Forty-three percent reported having no depression symptoms at all six
weeks after adding the dietary supplement to their treatment"
S-Adenosylmethionine (SAMe) - A Very Important Natural Product
- Dr. Murray's Natural Facts, 6/2/04 -
"SAMe is perhaps the most effective natural
antidepressant (although a strong argument could be made for the extract of
St. John's wort standardized to contain 0.3% hypericin)" - See
SAM-e Helps Beat Depression - WebMD, 5/5/04 -
"When SAM-e was added to their usual medication, half of the patients
improved and 43% went into remission, Alpert reports. "These are quite
strong responses and remission rates for a population that failed
S-Adenosyl Methionine May Be As Efficacious As Celecoxib in Management of
Knee Osteoarthritis, But Onset of Action Is Slower
- Doctor's Guide, 5/4/04 -
"During the first month of phase 1, celecoxib was
significantly more effective in reducing pain than was SAMe (P= .024);
however, by the second month of phase 1, patients in both groups had
significant pain improvement from baseline (PS</i>] < .01), and no
significant difference in pain was observed between groups"
A New Era for SAMe - Life Extension Magazine, 6/03
Cirque choreographer promotes new twist on joint health
- USA Today, 9/9/03
S-Adenosyl-L-Methionine Results Similar to Imipramine in Major Depression
- Doctor's Guide, 12/30/02 - "A total of 146
patients received 400 milligrams per day of intramuscular
SAMe and 147 received 150 mg/d of oral
SAMe and imipramine did not differ significantly on any efficacy measure,
either main or secondary ... Adverse events were significantly less in
patients treated with SAMe compared to those treated with imipramine"
- Note: There seems to be conflicting studies on whether oral SAMe is
poorly absorbed. I've added absorption studies near the bottom of my SAMe
page. Maybe the difference is "Enteric coating" tablets.
- SAMe Beneficial in
Treating Osteoarthritis, Depression, and Liver Disease
- New Hope Natural Media, 12/12/02 -
"More than 100 human studies have been published in
medical journals showing that SAMe is a safe, effective treatment and, in
the cases of
depression and osteoarthritis, works as
well as conventional medications"
SAM-e Same As Drugs - Functional Foods & Nutraceuticals, 12/02
Supplement [SAM-e] Found Effective As Antidepressant
- Intelihealth, 11/6/02 - "The dietary supplement
SAMe is about as effective as older, conventional
antidepressants in treating
depression, a preliminary, government-funded study says. It also finds
SAMe to be comparable to non-steroidal anti-inflammatory medications in
treating the pain of osteoarthritis. Such drugs include aspirin, ibuprofen
- Expert Panel
Finds SAMe Promising - WebMD, 10/10/02 - "As a
depression, SAMe was shown to be as effective as
antidepressants, and more effective
than placebo. SAMe also had fewer side effects when compared with standard
antidepressants ... As a treatment for
osteoarthritis, SAMe had fewer digestive side effects than
anti-inflammatory drugs like ibuprofen, yet was effective in relieving pain
... SAMe is a natural substance for the body, it's not a designer drug, and
therefore can be carried in, absorbed into pathways," ... The L-dopa
medication that patients take for Parkinson's makes them unusually
SAMe-deficient "because L-dopa consumes vast quantities of SAMe, like a
sponge, it mops up all the SAMe in the body." - See
SAMe aids arthritis without side effects - Life Extension Magazine,
The Wizard is Oz - Life Extension Magazine, 11/01 -
"Best-selling author and nutritional guru to the
rich and famous, Oz Garcia is singing the praises of the Life Extension
Foundation and its products in his newest book,
Healthy High Tech Body, published in September 2001 ... Supplements at
the top of Garcia's list of recommendations ...
DHA ... NADH ...
Alpah Lipoic Acid
... Acetyl-L-Carnitine ... An expanded list of his
recommendations includes lycopene,
gamma tocopherol, vinpocetine, SAMe, folic
glutathione, DMAE, Huperzine A,
IP-6, bioflavonoid formulas and
grape skin/seed extracts"
Some SAMe Supplements Found Lacking, About Half Had Less of the Active
Ingredient Than Labels Implied - WebMD. 5/29/01 -
"ConsumerLab.com found that about half the 13
products it tested were accurately labeled as to their SAMe content. Some
brands alleged to contain 200 mg actually had about half that, because
manufacturers factored in not just the weight of "free" SAMe -- the
"therapeutic" portion -- but also an inactive SAMe ingredient"
Caution in Treating PD Depression - Nutrition Science News, 5/01 -
"SAMe depletes dopamine and can produce PD-like changes in animals, causing
cell degeneration in the nigra and striatum areas of the brain"
Diet, Supplements, Exercise and Sauna - Life Extension Magazine, 9/99 -
"TMG, on the other hand, is very effective at
raising the levels of SAMe and lowering homocysteine."
SAMe Needs The B's - Nutrition Science News, 7/00 -
"users of this wonder pill should be aware that
through the natural metabolism of SAMe, the amino acid homocysteine is
created--a situation that can lead to artery damage and even heart disease.
. . . .others have demonstrated that by simply upping one's intake of the
vitamins B6, B12 and folic acid, this potential hazard can be avoided."
TMG is a precursor to SAM-e and lowers homocysteine instead of raising
Depression Protocol - Life Extension Foundation
Newsweek magazine, 3/22/99
"...SAM-e appears comparable to state-of-the-art
treatments for both conditions [arthritis and depression]. And unlike the
leading drug therapies, it lacks significant side effects. Dr. Richard Brown
[co-author of "Stop Depression Now"] a Columbia University Psychiatrist
describes it as the 'best anti-depressant I've ever prescribed." "...it's
cheaper than many prescription remedies. And if it lives up to its promise,
it may be more valuable."
Methionine (SAMe) Augmentation of Serotonin Reuptake Inhibitors for
Antidepressant Nonresponders With Major Depressive Disorder: A Double-Blind,
Randomized Clinical Trial - Am J Psychiatry. 2010 Jul 1 -
"These preliminary results suggest that SAMe can be
an effective, well-tolerated, and safe adjunctive treatment strategy for SRI
nonresponders with major depressive disorder and warrant replication"
S-adenosylmethionine in the chemoprevention and treatment of hepatocellular
carcinoma in a rat model - Hepatology. 2009 Apr 6 -
"SAMe is effective in preventing HCC establishment but ineffective in
treating established HCC because of induction of hepatic methyltransferases,
which prevents SAMe level to reach high enough to kill liver cancer cells.
SAMe's chemopreventive effect may be related to its proapoptotic action and
its ability to inhibit angiogenes"
Supplement S-Adenosyl-l-Methionine (AdoMet) Effects on Plasma Homocysteine
Levels in Healthy Human Subjects: A Double-Blind, Placebo-Controlled,
Randomized Clinical Trial - J Altern Complement Med. 2009 May 7 -
"S-adenosyl-l-methionine (AdoMet), a commonly used
nutritional supplement ... AdoMet at a daily dose of 800 mg for 4 weeks does
not appear to significantly affect Hcy levels in the blood"
of a Vitamin/Nutriceutical Formulation for Early-stage Alzheimer's Disease:
A 1-Year, Open-Label Pilot Study With an 16-Month Caregiver Extension -
Am J Alzheimers Dis Other Demen. 2008 Dec 1 - "We
examined the efficacy of a vitamin/nutriceutical formulation (folate,
vitamin B6, alpha-tocopherol, S-adenosyl methionine, N-acetyl cysteine, and
acetyl-L-carnitine) in a 12-month, open-label trial with 14
community-dwelling individuals with early-stage Alzheimer's disease.
Participants improved in the Dementia Rating Scale and Clock-drawing tests
(Clox 1 and 2). Family caregivers reported improvement in multiple domains
of the Neuropsychiatric Inventory (NPI) and maintenance of performance in
the Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADL).
Sustained performance was reported by caregivers for those participants who
continued in an 16-month extension. Performance on the NPI was equivalent to
published findings at 3 to 6 months for donepezil and exceeded that of
galantamine and their historical placebos. Participants demonstrated
superior performance for more than 12 months in NPI and ADL versus those
receiving naproxen and rofecoxib or their placebo group. This formulation
holds promise for treatment of early-stage Alzheimer's disease prior to
and/or as a supplement for pharmacological approaches"
S-adenosylmethionine blood levels in major depression: changes with drug
treatment - Acta Neurol Scand Suppl. 1994;154:15-8
S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical
studies - Acta Neurol Scand Suppl. 1994;154:7-14
Oral S-adenosylmethionine in depression: a randomized, double-blind,
placebo-controlled trial - Am J Psychiatry. 1990 May;147(5):591-5
The antidepressant potential of oral S-adenosyl-l-methionine
- Acta Psychiatr Scand. 1990 May;81(5):432-6
Intestinal absorption of S-adenosyl-L-methionine - J Pharmacol Exp Ther
(S-Adenosylmethionine) - James South -
"Because SAMe tablets are enterically coated, they
should NOT be cut in half to achieve a lower dose- the SAMe may then break
down before absorption"
Note: There seems to be conflicting studies on whether
oral SAMe is poorly absorbed. Maybe the difference is "Enteric coating"
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