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Anti-aging Research > Guggul
Guggul (Commiphora mukul)
News & Research:
Guggulipid Use in Hyperlipidemia - Medscape, 9/1/05 -
"Current data in the clinical literature do not
support the claims of guggulipid's efficacy in the treatment of
hyperlipidemia in a western population. Clinicians should advise their
patients with hyperlipidemia to avoid the use of guggulipid"
Guggul for Hypercholesterolemia - Medscape, 6/7/05 -
"Studies of the efficacy of guggul for
hypercholesterolemia have produced conflicting results. Information
currently available indicates that guggul may be effective for lowering
total cholesterol and triglycerides in patients on a non-Western diet. The
one study involving a typical American diet did not show any benefits; in
fact, patients taking guggul had slight increases in LDL cholesterol"
- Downside to
Cholesterol-Cutting Herbal Drug - WebMD, 9/24/04 -
"guggulsterone stimulates a cell's drug metabolism
machinery -- enzymes that break down prescription medicines. This action of
the herbal supplement would affect medications such as the AIDS drug AZT,
anticancer agents, and cholesterol-lowering statins"
- Guggulipid Does Not
Reduce Cholesterol Levels - Healthwell Exchange Daily News, 9/25/03
Herbal Extract, Guggulipid, Does Not Effectively Treat Hypercholesterolaemia
Among Western Population - Doctor's Guide, 8/13/03
- Popular Herb
Doesn't Help Bad Cholesterol - WebMD, 8/12/03 -
"In this study, 103 men and women -- all with high
cholesterol -- were separated into three groups. One group took three, 1,000
mg doses of guggulipid daily -- a standard dose; the second group got a
2,000 mg dose of guggulipid -- a high dose, and the third group got placebo
pills ... Those taking the placebo had 5% lower LDL cholesterol, whereas the
guggulipid group had higher LDL levels. Those taking the standard dose had
4% higher LDL levels, and the high-dose group had 5% higher LDLs"
Controlling Cholesterol Naturally - Natural Foods Merchandiser, 8/03
Ancient Folk Remedy [guggul] Points Toward Possible New Way To Control
Cholesterol - Intelihealth, 5/2/02 -
"The sap from a tree known in India as guggul
contains a compound that blocks the action of a cell receptor, called FXR,
that helps regulate the level of cholesterol in the body ... This mechanism
is completely different from the action of statin drugs ... finding a new
way to reduce cholesterol could be very important for patients who cannot
tolerate the side effects that some people experience with statin drugs"
- Natural Product
Lowers Cholesterol - WebMD, 5/2/02
Research: Use of Guggul Extract for the Treatment of Hypercholesterolemia
- Medscape, 4/02 -
"treatment with Gugulipid did not reduce serum
cholesterol, and may actually increase LDL"
Question regarding your new cholesterol-lowering supplement, Policosanol
- Life Extension Magazine, 11/01 -
"Studies show that niacin
(B3) in doses of 1.5 grams to 3 grams lower
triglycerides levels and raise
HDL concentrations. Those who tolerated higher doses
of niacin (nicotinic acid) showed even more improvement in lipid levels.
Some people taking just 1000 mg of
flush-free niacin see an elevation in beneficial HDL. Green tea also has
been shown to elevate levels of HDL while lowering serum triglyceride
levels. In the Journal of Molecular Cell Biochemistry,
curcumin has been demonstrated, in vivo, to decrease triglycerides and
increase HDL. In a study published in 1989 by the Journal of Associated
Physicians-India, 125 patients receiving gugulipid showed a drop of 16.8% in
triglycerides, and a 60% increase in HDL cholesterol within three to four
weeks. Make sure you are taking at least six
Mega EPA fish oil capsules daily, as low dose fish oil may not
adequately suppress triglycerides. Finally, there are some lifestyle changes
you may wish to consider. If you are overweight, weight loss would be
recommended, as it would help to lower triglycerides and raise HDL. Also,
try reducing carbohydrates, which can raise triglycerides"
- Evaluation of
the Antihyperlipidemic Properties of Dietary Supplements - Medscape,
"After 24 weeks of gugulipid treatment, total
cholesterol levels decreased by 25.2 mg/dl, compared with a 7.6 mg/dl
increase in the placebo group (p<0.01). The LDL was 16.9 mg/dl lower and 4.0
mg/dl higher, respectively ... In addition, a significant reduction in
triglycerides was seen in the gugulipid-treated arm compared with placebo
(-18 vs +5.5 mg/dl"
Tropical Remedies - Nutrition Science News, 5/00
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