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Home > Health Conditions > Hypertension > Calcium Channel Blockers.
Calcium Channel Blockers
Click here for why I feel
that Micardis® (telmisartan) should be the first
line treatment for hypertension.
Related Topics:
News & Research:
-
Telmisartan, an Angiotensin II Type 1 Receptor Blocker, Improves Coronary
Microcirculation and Insulin Resistance among Essential Hypertensive Patients
without Left Ventricular Hypertrophy - Hypertens Res. 2008 Apr;31(4):615-22
- "Coronary flow velocity reserve (CFVR) ... CFVR was
improved in the telmisartan group (2.4+/-0.4 to 2.9+/-0.4; p<0.01), but there
was no difference in the nifedipine group (2.5+/-0.3 to 2.5+/-0.3; n.s.).
HOMA-IR was improved in the telmisartan group (3.1+/-1.1 to 1.6+/-0.7; p<0.01),
but there was no difference in the nifedipine group (2.8+/-1.1 to 2.4+/-0.7; n.s.).
In conclusion, this study demonstrates that antihypertensive therapy with
telmisartan, but not nifedipine, has a beneficial effect on coronary
microcirculation and insulin resistance among essential hypertensive patients"
-
2-drug
Blood Pressure Therapy Dramatically Lowers Cardiovascular Risk - Science
Daily, 3/31/08 - "One group received a tablet containing
benazepril, which is a type of drug called an ACE inhibitor, and amlodipine,
which belongs to a class of drugs known as calcium channel blockers or CCBs. The
other pill combined benazepril and hydrochloro-thiazide, a type of diuretic or
"water pill." The 20 percent reduction in cardiovascular events was observed
with the ACE/CCB combination tablet"
-
Reduced
incidence of new-onset atrial fibrillation with angiotensin II receptor
blockade: the VALUE trial - J Hypertens. 2008 Mar;26(3):403-411 -
"These findings suggest that angiotensin II receptor
blockers may result in greater benefits than calcium antagonists in hypertensive
patients at risk of new-onset AF"
-
The development of new-onset type 2 diabetes associated with choosing a calcium
channel blocker compared to a diuretic or beta-blocker - Curr Med Res Opin.
2007 Apr 23 - "Calcium channel blockers may be
associated with reduced odds of developing new-onset type 2 diabetes compared to
diuretics and beta-blockers" - Yeah but the odds are even less with ACE
inhibitors or ARBs than with calcium channel blockers.
-
One Pill
May Be Better Than Two For Treating Patients With High Blood Pressure -
Science Daily, 5/11/07 - "Adults with
high blood pressure and additional risk factors for heart disease may benefit
more from taking one tablet rather than two, if their current treatment combines
the lipid-lowering medication atorvastatin with the blood pressure-lowering
medication amlodipine"
-
Fasting
Glucose Increases in Older Adults With Hypertension Regardless of Treatment Type
- Medscape, 11/16/06 - "randomized to
receive treatment with chlorthalidone, amlodipine, or lisinopril to reduce blood
pressure to less than 140/90 mm Hg ... During the first 2 years, the mean
increase is serum glucose levels was 8.5, 5.5, and 3.5 mg/dL among the
chlorthalidone, amlodipine, and lisinopril groups, respectively"
-
Fasting glucose levels and incident diabetes mellitus in older nondiabetic
adults randomized to receive 3 different classes of antihypertensive
treatment: a report from the Antihypertensive and Lipid-Lowering Treatment
to Prevent Heart Attack Trial (ALLHAT) - Arch Intern Med. 2006 Nov
13;166(20):2191-201 - "Mean FG
levels increased during follow-up in all treatment groups. At year 2, those
randomized to the chlorthalidone group had the greatest increase (+8.5 mg/dL
[0.47 mmol/L] vs +5.5 mg/dL [0.31 mmol/L] for amlodipine and +3.5 mg/dL
[0.19 mmol/L] for lisinopril)"
-
Reduced Diabetes Likelihood in Hypertensives Starting Valsartan Treatment
- Doctor's Guide, 5/18/06 - "Over a
mean follow-up of 4.2 years, the risk of diabetes was 11.5% for valsartan
versus 14.5% for amlodipine; the odds ratio was 0.77 in favor of valsartan"
-
Diabetic Hypertensives Improve with Addition of Dihydropyridine Calcium
Channel Blocker - Doctor's Guide, 5/17/06
-
Effects of Valsartan Compared to Amlodipine in Prevention of Type 2 Diabetes
in High-Risk Hypertensive Patients: Presented at EMH - Doctor's Guide,
6/24/05 - "Valsartan is
significantly superior to amlodipine for prevention of new-onset type-2
diabetes in high-risk patients with hypertension"
-
Valsartan Significant Better Than Amlodipine for Improving Long-term
Heart-rate Variability in Patients With LVH: Presented at EMH - Doctor's
Guide, 6/20/05
-
Amlodipine and Atorvastatin Combination May Help Relax Arteries -
Doctor's Guide, 5/20/05 - "the
calcium channel blocker amlodipine (Norvasc) and the cholesterol-lowering
agent atorvastatin (Lipitor) both reduce arterial stiffness in the small
arteries ... Stiff arteries are old arteries ... Relaxing the arteries is
beneficial for cardiovascular health"
-
Blood Pressure
Linked to Erectile Dysfunction - WebMD, 5/16/05 -
"Men on older high blood pressure
medications (diuretics, beta-blockers) had higher rates and more severe
erectile dysfunction than men on newer medications (calcium antagonists, ACE
inhibitors, angiotensin II receptor blockers)"
- Do Some Blood Pressure Drugs Up Heart Risk? - WebMD, 12/14/04 -
"We found that [high-blood-pressure] therapy combinations that contain the calcium channel
blockers were associated with a higher risk of death from heart disease than were other combinations"
- Amlodipine More Effective for Blood Pressure Reduction but Confers Similar Cardiac Outcomes to Valsartan Therapy - Doctor's Guide, 6/18/04
- Significant Reduction in Left Ventricular Mass Index, Reactive Oxygen Species Formation and C-Reactive Protein With Valsartan Treatment - Doctor's Guide, 6/18/04 -
"Despite very similar effects on BP, there was a significantly higher reduction in LVMI with valsartan compared with amlodipine ... In
the valsartan group, CRP levels were significantly reduced"
- Newer Drug Helps Prevent Heart Attack - HealthDay, 6/17/04 -
"people taking valsartan had much lower rates of admission to hospital
for heart failure. And fewer people in the valsartan group (13 percent) developed type 2 diabetes than those in the amlodipine group (16 percent)"
- Norvasc (Amlodipine Besylate) Appears to Achieve Superior Blood Pressure Control with Fewer Heart Attacks - Doctor's Guide, 6/16/04
- Verapamil SR Has More Favorable Impact on Mood Than Atenolol in Hypertensive Patients - Doctor's Guide, 5/25/04
- Valsartan May Produce Lower Ambulatory Heart Rate, Greater Lowering of Daytime Systolic Blood Pressure than Amlodipine in Elderly Patients with Systolic Hypertension - Doctor's Guide,
5/6/04
- Irbesartan More Effective Than Amlodipine in Reducing Left Ventricular Mass Index - Doctor's Guide, 11/4/03 -
"Several studies have established
that LVH is a powerful BP-independent cardiovascular risk factor; however, not all antihypertensive drugs can reverse LVH ...
After 3 months, echocardiographically estimated LVMI decreased by 23.2% in the
irbesartan-treated patients and 11.4% in the amlodipine-treated patients"
- Amlodipine Besylate/Benazepril HCl Combination Works Best for Lowering Blood Pressure - Doctor's Guide, 10/12/03
- Nilvadipine Lowers Low-Density Lipoprotein in Hypertensive Patients - Doctor's Guide, 10/1/03
- Eplerenone Better Tolerated and as Effective in Reducing Systolic BP Than Amlodipine - Doctor's Guide, 8/7/03
- Intranasal Nifedipine Safe in Patients With Hypertension Prior To Surgery - Doctor's Guide, 7/4/03
- Calcium Channel Blockers May Not Add to ACE Inhibition in Nondiabetic Nephropathy - Doctor's Guide, 6/12/03
- Periodic Limb Movements Increase with Isradipine, Decrease with Atenolol - Doctor's Guide, 5/21/03
- Lercandipine Effective in Treating Hypertension in Patients with Chronic Kidney Failure - Doctor's Guide, 5/21/03
- Angiotensin II Receptor Blockers Effective, Better Tolerated than Calcium Channel Blockers in Elderly Patients - Doctor's Guide, 5/21/03 -
"Valsartan
and amlodipine are both highly effective in controlling blood pressure in patients with isolated systolic hypertension ... However, valsartan offers a significant tolerability advantage as it shows a reduced risk of developing adverse events"
- Amlodipine Alone or in Combination with other Drugs Reduces Systolic Blood Pressure - Doctor's Guide, 5/21/03 -
"The mean
reduction in systolic blood pressure was approximately 17 mm Hg, while diastolic blood pressure decreased an average of 8 mm Hg, irrespective of regimen"
- Sustained-Release Isradipine Superior to Sustained-Release Amlodipine for Round-the-Clock Blood Pressure Control - Doctors' Guide, 5/20/03
- Nocturnal Dosing of Graded-Release Diltiazem Tops Nocturnal Ramipril for Blood Pressure Control - Doctor's Guide, 5/20/03
- Calcium Blockers Not Better Than Other Drug Classes - Doctor's Guide, 5/12/03
- Drugs Cut Heart Risk in Bypass Patients - HealthDay, 5/9/03
- Eplerenone As Effective As Amlodipine For Systolic Hypertension, Widened Pulse Pressure - Doctor's Guide, 4/28/03
- Once Daily Coat-Core Nifedipine Has The Advantage Over Amlodipine In Essential Hypertension - Doctor's Guide, 4/16/03
- No Differences Seen Between Calcium Channel Blocker and Beta Blocker in INVEST Trial - Doctor's Guide, 4/3/03
- Lisinopril/Nifedipine GITS Combination More Effective Than Either Drug Alone In Reducing Blood Pressure - Doctor's Guide, 4/1/03
- Nifedipine Could Be First-Line Therapy For Hypertensive Diabetics - Doctor's Guide, 3/25/03
- Cardizem LA for Hypertension - Physician's Weekly, 2/24/03
- Nisoldipine-Extended Release, Amlodipine Comparable In Safety, Efficacy For Hypertensive And Angina Therapy - Doctor's Guide, 2/20/03
- Amlodipine Appears To Provide Greater Reduction In Blood Pressure Than Does Losartan - Doctor's Guide, 2/6/03 -
"Diastolic blood pressure equal
to or below 90 mm Hg was achieved by 43.6% of the amlodipine patients and 42.3% of the losartan patients. Seventy-one percent of the amlodipine
and 81% of the losartan patients who continued treatment with the original dose reached blood pressure goals ... However, among those patients who required dosage adjustments, a significantly higher number of amlodipine
patients reached blood pressure goals. Fifty-nine percent of the amlodipine patients compared with 42%"
- Amlodipine's Antihypertensive Effect Persists Longer Than Nifedipine Gastrointestinal Therapeutic System After Missed Doses - Doctor's Guide, 2/3/03
- Blood Pressure Control -- Timing Matters - WebMD, 1/24/03 -
"Researchers found that the diuretic and calcium-channel
blocker were effective around the clock. The beta-blocker was the least effective of the four drugs overall and it had no effect on blood pressure during the night or in the early morning hours. ACE inhibitors actually worked best while the study
participants were sleeping, but had little effect on blood pressure during the day"
- Bedtime Graded-Release Diltiazem More Effective Than Morning Administration - Doctor's Guide, 1/13/03
- Calcium Channel Blockers Differ in Long-Term Tolerability - Doctor's Guide, 12/2/02
- Diltiazem Prevents Death and Myocardial Infarction during Non-cardiac Surgery - Doctor's Guide, 11/26/02
- Incidence of Cardiac Events Similar Between Amlodipine And Irbesartan in Diabetic Patients with Overt Nephropathy - Doctor's Guide, 11/1/02
- Controlled Onset Extended Release Verapamil At Bedtime May Better Control Morning Blood Pressure, Heart Rate - Doctor's Guide, 10/9/02
- FDA Looking for Grapefruit Interactions - Doctor's Guide, 9/23/02 -
"If a drug has a large first pass effect, consuming grapefruit could cause a
higher drug dose to enter the bloodstream through any of these actions ... Two drugs Dr. Piazza-Hepp cited as coming recently under suspicion are amlodipine, a calcium channel blocker, and atorvastatin"
- Calcium Channel Blockers May Have Neuroprotective Effect - Doctor's Guide, 7/24/02
- Use of a Calcium Channel Blocker in Depressed Patients - Medscape, 9/18/02
-
Patient Compliance with Antihypertensive Therapy Appears Longer
for Those Taking Angiotensin II Antagonists - Doctor's
Guide, 7/18/02 - "The researchers found that the
class of drug had a statistically significant effect on the patients'
persistence of compliance. Angiotensin II antagonists had the highest rate
of persistence followed by ACE inhibitors, calcium channel blockers,
beta-blockers, and diuretics"
- New Formulation Of Lotrel (Amlodipine/Benazepril), 10/20 mg, Now Available - Doctor's Guide, 7/15/02
- Olmesartan Medoxomil and Amlodipine Equally Effective for Mild to Moderate Hypertension - Doctor's Guide, 5/19/02
- Controlled Release Extended Release Verapamil Fails to Meet Goal in CONVINCE Trial - Doctor's Guide, 5/19/02
- Nighttime Dosing with Extended Release Diltiazem Controls Blood Pressure - Doctor's Guide, 5/19/02
- Useful Role of Chronotherapeutic Verelan PM (Verapamil) Confirmed in Multiple Subgroups - Doctor's Guide, 5/19/02
- Combination of Amlodipine/Benazepril Reduces Edema, Controls Blood Pressure After Monotherapy Failure - Doctor's Guide, 5/19/02
- Commonly Available Drugs Might Slow Progress of Age-related Dementia - Doctor's Guide, 10/8/01
- Long-term Irbesartan, Amlodipine Normalizes Resistance Artery Structure and Endothelial Function - Doctor's Guide, 9/25/01
- Scientists Find Drug [Isradipine] Helps Stop Strokes - Intelihealth, 8/20/01
- Amlodipine, Fosinopril have Equivalent Effects on Left Ventricular Hypertrophy and Urinary Albumin Excretion - Doctor's Guide, 6/20/01
- Calcium Antagonist, Lacipidine, Reduces Plaque Progression Compared To Atenolol - Doctor's Guide, 6/19/01
- Norvasc (Amlodipine Besylate) Valuable For Treating High Blood Pressure in Diabetics - Doctor's Guide, 5/22/01
- Nitrendipine Antihypertensive Does Not Negatively Affect Renal Function - Doctor's Guide, 4/3/01
- Extended Release Felodipine "Drug Holiday" Undermines Blood Pressure Control - Doctor's Guide, 4/2/01
- Nifedipine And Verapamil Differ Pharmacologically But Are Equally Effective - Doctor's Guide, 3/19/01
- Diuretics And Calcium Antagonists Best Reduce Systolic Pressure In Untreated Elderly Hypertensives - Doctor's Guide, 3/19/01 -
"Initial treatment of elderly people
with essential hypertension should consist of thiazide diuretics or calcium-antagonists ... These are more effective than other agents at lowering systolic blood pressure"
- Nifedipine Might Interfere With Exercise-Induced Blood Pressure Changes - Doctor's Guide, 1/30/01
-
Nifedipine Linked To Male Infertility - Doctor's Guide, 9/21/99
- Major Studies Support Safety of Calcium Channel Blockers - Doctor's Guide, 11/13/96
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