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Home > Health Conditions > Hardening of the Arteries

Hardening or Stiffening of the Arteries

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  • Atherosclerosis - Life Extension Magazine
  • Atherosclerosisicon - Vitacost
  • Lycopene as effective as statins for artery health: rabbit study - Nutra USA, 7/3/08 - "The results of our experiment in the high-fat diet rabbit model showed that lycopene and fluvastatin lowered serum levels of total cholesterol and LDL-cholesterol, improved lipid metabolism, and reduced the amount of triacylglycerols ... Lycopene intervention reduced the increase in ox-LDL levels in rabbits on the high-fat diet, whereas fluvastatin did not show such an effect. The cause of this difference is at present not known, although the result speaks in favour of lycopene ... These findings provide a theoretical rationale for the use of lycopene as a preventive in atherosclerosis" - [Abstract] - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at iHerb.
  • Comparison of lycopene and fluvastatin effects on atherosclerosis induced by a high-fat diet in rabbits - Nutrition. 2008 Jun 26 - "Compared with the control, levels of total cholesterol, total triacylglycerol, low-density lipoprotein cholesterol, malonaldehyde, oxidized low-density lipoprotein, and interleukin-1 were increased and total antioxidant capacity and nitric oxide were decreased in the animals with a high-fat diet (P < 0.05). Intragastric administration of lycopene counteracted the change in these parameters (P < 0.05). In this case, the data showed that lycopene in the used dose was better than the fluvastatin intervention. Morphologic analysis revealed that lycopene and fluvastatin markedly reduced the formation of atherosclerotic plaques in the aorta compared with the situation in rabbits on a high-fat diet alone ... Lycopene, like fluvastatin, significantly attenuated atherogenesis in rabbits fed a high-fat diet" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at iHerb.
  • Failure To Bridle Inflammation Spurs Atherosclerosis - Science Daily, 6/18/08 - "When a person develops a sore or a boil, it erupts, drawing to it immune system cells that fight the infection. Then it resolves and flattens into the skin, often leaving behind a mark or a scar ... A similar scenario plays out in the blood vessels. However, when there is a defect in the resolution response -- the ability of blood vessels to recover from inflammation -- atherosclerosis or hardening of the arteries can result ... Some natural mediators that 'cool' this inflammation are derived from omega-3 polyunsaturated fatty acids" - See Mega Twin EPA at iHerb.
  • Serum DHEA-S Level Is Associated with the Presence of Atherosclerosis in Postmenopausal Women with Type 2 Diabetes Mellitus - Endocr J. 2008 May 21 - "intima-media thickness (IMT) ... Although simple regression analysis showed that log(DHEA-S) and IGF-I in men and log(DHEA-S) in women were significantly and inversely correlated with baPWV and IMT, only log(DHEA-S) in women was still significantly and inversely correlated with these atherosclerotic parameters after multiple regression analysis was adjusted for age, duration of diabetes, BMI, HbA(1C), systolic blood pressure, LDL-Cholesterol (C), serum creatinine, and smoking (Brinkman index). Serum DHEA-S level seemed to be associated with atherosclerosis in diabetic postmenopausal women independent of age, body stature, diabetic status, and other atherosclerotic risk factors, and might be a useful addition to other parameters for assessing the risk of atherosclerosis in this population" - See DHEA products at iHerb.
  • Vitamin C consumption is associated with less progression in carotid intima media thickness in elderly men: A 3-year intervention study - Nutr Metab Cardiovasc Dis. 2008 May 7 - "Vitamin C containing foods may protect against the progression of carotid atherosclerosis in elderly men"
  • Juicing may boost a fruit's antioxidant punch: study - Nutra USA, 5/2/08 - "The juices also outperformed the fruit for protecting against atherosclerosis, measured by the aortic fatty streak lesion area or AFSA. This value was reduced by 93 and 78 per cent for the purple grape juice and the fruit, respectively, and by 60 and 48 per cent for apple juice and apple, respectively ... The results show for the first time that long-term consumption of antioxidants supplied by apple and purple grape, especially phenolic compounds, prevents the development of atherosclerosis in hamsters, and that processing can have a major impact on the potential health benefits of a product"
  • Phenolics from purple grape, apple, purple grape juice and apple juice prevent early atherosclerosis induced by an atherogenic diet in hamsters - Mol Nutr Food Res. 2008 Apr;52(4):400-7 - "The results show for the first time that long-term consumption of antioxidants supplied by apple and purple grape, especially phenolic compounds, prevents the development of atherosclerosis in hamsters, and that processing can have a major impact on the potential health benefits of a product. The underlying mechanism is related mainly to increased antioxidant status and improved serum lipid profile"
  • Omega-3 may boost blood vessel elasticity - study - Nutra USA, 9/21/07 - "fish oil supplementation improved large artery elasticity, compared to placebo (15.51.5 versus 12.83.7 ml.mm.Hg-1 x 10, respectively)" - See Mega Twin EPA at iHerb.
  • Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells - Atherosclerosis. 2007 Sep 17 - "both quercetin and its metabolites, at physiological concentrations, can inhibit the expression of key molecules involved in monocyte recruitment during the early stages of atherosclerosis" - See quercetin products at iHerb.
  • Fish oil supplementation improves large arterial elasticity in overweight hypertensive patients - Eur J Clin Nutr. 2007 Sep 5 - "After 8 weeks follow-up, the large artery elasticity in the fish oil group, compared with its baseline, was significantly improved (C(1): 15.5+/-1.5 vs 12.8+/-3.7 ml mm Hg(-1) x 10), whereas no effects were found in the placebo group (C(1): 13.0+/-3.4 vs 13.4+/-3.8 ml mm Hg(-1) x 10), P=0.027, RM-ANOVA across the two groups" - See Mega Twin EPA at iHerb.
  • Vitamin K may reverse artery hardening, suggests study - Nutra USA, 12/11/06 - "A high-dose vitamin K supplement reduced calcium precipitates associated with hardening of the arteries by 37 per cent in rats"
  • l-Arginine, the substrate for NO synthesis: An alternative treatment for premature atherosclerosis? - Int J Cardiol. 2006 Jul 20 - "l-arginine administration may be useful in patients with premature atherosclerosis" - See iHerb or Vitacosticon l-arginine products.
  • Eat Your Veggies, Help Your Arteries - WebMD, 6/19/06 - "They found 38% less plaque in the arteries of mice that had eaten the vegetable-rich diet, compared with mice that had eaten no vegetables"
  • Veg 'prevents artery hardening' - BBC News, 6/18/06 - "US researchers found 38% less build up of fatty deposits in the arteries of mice who were fed a mixture of vegetables, including carrots and peas"
  • Combination Treatment Shown for First Time to Cause Regression of Atherosclerosis - Doctor's Guide, 11/16/05 - "reversal of atherosclerosis - a primary cause of stroke and heart attacks - can be achieved with a combination of Niaspan (prolonged-release nicotinic acid) and a statin ... ARBITER 2 clearly showed that statins alone are not enough to halt the progression of atherosclerosis even when the LDL-C target is met. However, the addition of Niaspan 1000 mg stopped the progression of atherosclerosis in 12 months ... a further 12 months of treatment with Niaspan and a statin actually achieves regression of atherosclerosis"
  • Why Our Arteries Become Clogged As We Age - Life Extension Magazine, 10/05 - "Two natural compounds—propionyl-l-carnitine (PLC) and PEAK ATP™—offer promise in restoring and maintaining healthy endothelial function while supporting cellular energy metabolism. PLC provides energy to the heart and vascular cells by promoting optimal energy metabolism in the mitochondria. PEAK ATP™ boosts energy levels and vascular health by restoring youthful levels of ATP in red blood cells, tissues, and organs" - See Ester Carnitine Propionyl at iHerb.
  • Grapeseed extract may stop arteries from hardening - Nutra USA, 6/23/05 - "grapeseed extract stopped cholesterol from building up in the arteries of guinea pigs, which in turn leads to the thickening and hardening of the vessels and the resulting condition, atherosclerosis" - See iHerb or Vitacosticon grapeseed extracts.
  • Too Little Magnesium Tied to Artery Troubles - HealthDay, 4/30/05 - "dietary magnesium intake was inversely related to coronary artery calcium levels ... Previous research found that changes in fat metabolism caused by magnesium deficiency are linked to the development of atherosclerosis and that magnesium intake is an important factor in controlling fat metabolism in the walls of arteries"
  • DHEA May Fight Heart Disease, But How? - WebMD, 7/23/03 - "Endothelial dysfunction is known to contribute to atherosclerosis or hardening of the arteries ... men who received 25 mg per day of DHEA supplements for 12 weeks experienced significant improvement in endothelial function as well as insulin sensitivity compared with those who took a placebo" - See iHerb or Vitacosticon DHEA products.
  • High Dietary Calcium Intake Associated with Lower Age-Related Hypertension - Doctor's Guide, 7/16/03 - "In industrialized nations, SBP increases with age, whereas diastolic blood pressure (DBP) tends to decrease with age, thereby increasing pulse pressure (defined as the difference between SBP and DBP) ... higher calcium intake was associated with lower rates of age-related increases of systolic blood pressure and pulse pressure ... If the calcium intake of the general population were to increase to above 1,200 mg, the incidence of isolated systolic hypertension in the elderly might be decreased" - See drugstore.com/GNC calcium supplementsicon.
  • A Drink a Day Keeps Arteries Healthy - WebMD, 5/15/03 - "moderate drinkers had increased elasticity in both small and large arteries as well as lower heart rates compared with nondrinkers ... Beer drinkers had the highest blood pressure levels, followed by liquor and wine drinkers"
  • One Glass of Wine Per Day Improves Arterial Elasticity - Doctor's Guide, 5/15/02 - "Modest alcohol intake was defined as no more than one glass of wine or beer, or less than 30 mL of hard alcohol daily ... All drinkers, particularly wine drinkers, demonstrated increased elasticity in both small and large arteries, as well as lower heart rates, compared with nondrinkers ... The only negative effect associated with moderate drinking was a slight increase in systolic and diastolic blood pressure. Beer drinkers showed the highest blood-pressure elevations ... moderate wine drinking is associated with higher arterial elasticity, lower pulse rate, and higher stroke volume"
  • Protecting Blood Vessels From Stress - WebMD, 1/15/02 - "vitamins can improve blood flow and prevent the long-term development of atherosclerosis -- or hardening of the arteries -- when given in combination with an amino acid known as L-arginine ... antioxidants might work together with L-arginine to prevent inflammation in the branch areas of blood vessels ... although antioxidants may not reverse or repair pre-existing damage within blood vessels, they may slow the long-term progression of atherosclerosis" - See iHerb and Vitacosticon l-arginine products.
  • Vitamin C, Fish, And A Gout Drug Target Artery Damage From Smoking - Intelihealth, 1/7/03 - "vitamin C and taurine, an amino acid in fish, reversed abnormal blood vessel response associated with cigarette smoking - a discovery that may provide insight into how smoking contributes to "hardening of the arteries,""
  • Evidence-based Products - Functional Foods & Nutraceuticals, 12/02 - "3g EPA/d and 3g DHA/d (ROPUFA) increased systemic arterial compliance in 38 dyslipidemic men and women, resulting in reduced pulse pressure and total vascular resistance ... Results showed that ROPUFA increased SAC—36 per cent with EPA and 27 per cent with DHA—compared with placebo" - See Mega Twin EPA at iHerb or Vitacosticon and Jarrow Max DHA at iHerb.
  • Pycnogenol Helps Hypertension - Nutrition Science News, Spring '02 - "A new study conducted at the University of Arizona Health Sciences Center in Tucson shows that pycnogenol, an extract of French maritime pine bark (Pinus maritima) may lower blood pressure in mildly hypertensive patients"

General Information:

  • Atherosclerosis - American Academy of Family Physicians
  • Atherosclerosis - emedicine.com
  • Atherosclerosis - FamilyDoctor.org
  • Erectile Dysfunction / Impotence - Prostate Health Guide - U. of Maryland Medicine - "There are 5 million adult men in the US with diabetes, and it is estimated that half are impotent and the other half will become impotent in time. The process involves premature and unusually severe hardening of the arteries. Peripheral neuropathy, with involvement of the nerves controlling erections, is commonly seen in persons with diabetes"

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