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Anti-aging Research > Taurine
News & Research:
Nutrient found in dark meat of poultry, some seafood, may have
cardiovascular benefits - Science Daily, 3/1/12 -
"funded by the American Heart Association ... The
comparison revealed serum taurine was not protective of CHD overall.
However, among women with high cholesterol, those with high levels of serum
taurine were 60 percent less likely to develop or die from CHD in the study,
compared to women with lower serum taurine levels. If future studies are
able to replicate the findings, taurine supplementation or dietary
recommendations may one day be considered for women with high cholesterol at
risk for CHD"
Taurine: Key To The Visual Toxicity Of An Anti-epileptic Drug For Children?
- Science Daily, 2/17/09 - "Vigabatrin (Sabril),
first intention molecule for the treatment of epilepsy in children, in many
cases produces secondary effects that lead to an irreversible loss of vision
... vigabatrin provokes a marked decrease in the blood level in an amino
acid, taurine, resulting in a degeneration of the retina cells induced by
light. The researchers therefore suggest that exposure to light should be
reduced and a taurine-rich diet introduced in order to curb immediately
these secondary effects in children undergoing treatment"
- Topping Off Energy with
Taurine? - Dr. Weil, 5/30/03
Taurine Be A Potent Antioxidant Drug In The Future? - Science Daily,
9/19/08 - "Taurine is a potent antioxidant with
hepatoprotective effects. Organelle based changes in hepatocytes after
taurine treatment in experimental liver fibrosis were searched
systematically and organelle injury scores decreased were found to decrease
Taurine reverses damage done by smoking and protects against heart disease
- Life Extension Magazine, 3/03
Vitamin C, Fish, And A Gout Drug Target Artery Damage From Smoking
- Intelihealth, 1/7/03 -
and taurine, an amino acid in fish, reversed abnormal blood vessel response
associated with cigarette smoking - a discovery that may provide insight
into how smoking contributes to "hardening
of the arteries,""
- Taurine Helps Correct
Iron-Deficiency Anemia - New Hope Natural Media, 12/19/02 -
"Half of the women were also given taurine (1,000 mg per day), while the
others received a placebo ... the group receiving taurine had a
significantly greater increase in blood count than did the placebo group.
The advantage of taurine over placebo was equivalent to the production of
more than three-quarters of a pint of additional blood"
Taurine and magnesium
supplementation enhances the function of endothelial progenitor cells through
antioxidation in healthy men and spontaneously hypertensive rats - Hypertens
Res. 2016 Jul 14 - "Endothelial damage is repaired by
endothelial progenitor cells (EPCs), which are pivotal in preventing
cardiovascular diseases and prolonging lifespan ... Taurine and Mg
supplementation increased EPC colony formation in healthy men and improved
impaired EPC function in SHRs through antioxidation, indicating that the dietary
intake of taurine and Mg may prolong lifespan by preventing the progression of
cardiovascular diseases" - See
Magtein at Amazon.com
taurine at Amazon.com.
The role of
taurine in improving neural stem cells proliferation and differentiation -
Nutr Neurosci. 2016 Feb 23 - "Taurine plays an important
role in brain development, including neuronal proliferation, stem cell
proliferation, and differentiation, via several mechanisms. Taurine can be
directly used in clinical applications to improve brain development because it
has no toxic effects on humans"
Supplementation Lowers Blood Pressure and Improves Vascular Function in
Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study -
Hypertension. 2016 Jan 18 - "We randomly assigned 120
eligible prehypertensive individuals to receive either taurine supplementation
(1.6 g per day) or a placebo for 12 weeks. Taurine supplementation significantly
decreased the clinic and 24-hour ambulatory BPs, especially in those with
high-normal BP. Mean clinic systolic BP reduction for taurine/placebo was
7.2/2.6 mm Hg, and diastolic BP was 4.7/1.3 mm Hg. Mean ambulatory systolic BP
reduction for taurine/placebo was 3.8/0.3 mm Hg, and diastolic BP was 3.5/0.6
mm Hg. In addition, taurine supplementation significantly improved
endothelium-dependent and endothelium-independent vasodilation and increased
plasma H2S and taurine concentrations"
taurine intake and taurine synthesis improves skeletal muscle function in the
mdx mouse model for Duchenne Muscular Dystrophy - J Physiol. 2015 Dec 12 -
"Duchenne Muscular Dystrophy (DMD) is a fatal muscle
wasting disease for which there is no widely available cure ... Increasing the
taurine content of mdx muscle improved both in vivo and ex vivo muscle strength
and function, potentially via anti-inflammatory and antioxidant effects of
taurine ... These data support continued research into the use of taurine as a
therapeutic intervention for DMD, and suggest that increasing dietary taurine is
the better strategy for increasing taurine content and decreasing severity of
The role of
taurine in the pathogenesis of obesity - Mol Nutr Food Res. 2015 Mar 19 -
"Ingestion of taurine has been shown to alleviate
metabolic diseases such as hyperlipidemia, diabetes, hypertension, and obesity
in animal models. A global epidemiological survey showed that 24-h urinary
taurine excretion, as a marker of dietary taurine intake, was inversely
associated with body mass index, blood pressure, and plasma cholesterol in
Antidepressant dose of taurine increases mRNA expression of GABAA receptor α2
subunit and BDNF in the hippocampus of diabetic rats - Behav Brain Res. 2015
Jan 19 - "Diabetes mellitus is a metabolic disorder
associated with higher risk for depression. Diabetic rats present
depressive-like behaviors and taurine, one of the most abundant free amino acids
in the brain, reverses this depressive behaviors ... Real-time quantitative PCR
(qPCR) showed that diabetic rats presented lower α2 GABAA subunit and BDNF mRNA
expression than non-diabetic rats and taurine increased both parameters in these
sick rats. Taurine also reversed the lower brain weight and improved the
short-term memory in diabetic rats. Thus, the taurine antidepressant effect may
be explained by interference with the GABA system, in line to its
neuroprotective effect showed here by preventing brain weight loss and improving
memory in diabetic rats"
attenuates amyloid β 1-42-induced mitochondrial dysfunction by activating of
SIRT1 in SK-N-SH cells - Biochem Biophys Res Commun. 2014 Apr 12 -
β (Aβ) plays a critical role in the pathogenesis of Alzheimer disease (AD) ...
Taurine, a naturally occurring β-amino acid in the brain, has been demonstrated
to have neuroprotective properties ... Our results suggest that taurine prevents
Aβ1-42-induced mitochondrial dysfunction by activation of SIRT1. This study
implies that taurine is a prospective additive for AD patients"
improves obesity-induced inflammatory responses and modulates the unbalanced
phenotype of adipose tissue macrophages - Mol Nutr Food Res. 2013 Aug 12 -
"It is increasingly accepted that chronic inflammation
is a feature of obesity. Obesity-induced inflammation triggers enhanced
recruitment of macrophages into the adipose tissue. Depending on their
phenotype, macrophages can be designated either as pro-inflammatory M1
macrophages or anti-inflammatory M2 macrophages ... Our findings indicate that
taurine treatment attenuates the infiltration of adipose tissue by macrophages
and modulates the phenotype of macrophages, which suggest that taurine is a
valuable food constituent with a potential to attenuate chronic inflammation in
adipose tissue and improve obesity-related insulin resistance"
supplementation restored the changes in pancreatic islet mitochondria in the
fetal protein-malnourished rat - Br J Nutr. 2011 May 31:1-9 -
"Intra-uterine growth retardation has been linked to the
development of type 2 diabetes in later life. Mitochondrial changes have been
suggested as a link between fetal malnutrition and adult insulin resistance.
Taurine has been implicated in this process ... Male offspring of rats fed a
control diet, a low-protein diet or a low-protein diet supplemented with taurine
during pregnancy and lactation were weaned onto the control diet. In each group,
at 20 weeks of age, intravenous glucose tolerance tests,
euglycaemic-hyperinsulinaemic clamp studies, morphometric analysis of the
pancreatic islets and ultra-structural analysis of the mitochondria of the
β-cells were performed. The expressions of cytochrome c oxidase (COX) I and
mitochondrial respiratory chain complex II were also measured. Fetal
protein-malnourished rats showed decreased pancreatic islet mass and reduced
insulin-secretory responses to a glucose load. These rats also showed reduced
mitochondrial DNA-encoded COX I gene expression in the islets. Electron
microscopic examination showed abnormal mitochondrial shapes in the β-cells of
fetal protein-malnourished rats. Taurine supplementation to the low-protein diet
restored all these changes. Our findings indicate that a maternal
protein-restriction diet causes long-lasting mitochondrial changes that may
contribute to the development of type 2 diabetes later in life. The lack of
taurine may be a key causative factor for these dysfunctional mitochondrial
effect of taurine on diabetic rat endothelial dysfunction - Biomed Res.
2011;32(3):187-93 - "Although taurine treatment failed
to decrease serum glucose levels, the increased serum malondialdehyde levels in
diabetic rats were significantly decreased after taurine treatment.
Norepinephrine-induced hyper-contractility as well as acetylcholine-induced,
endothelium-dependent hypo-relaxation in diabetes were significantly prevented
after taurine treatment. The differences in the expressions of muscarinic M(3)
receptor mRNAs were statistically non-significant between groups. Moreover,
diabetes-induced up-regulation of eNOS mRNAs was slightly prevented after
taurine treatment. These data suggest that taurine acts beneficially against the
diabetes-induced vascular dysfunction. Its potential action as a radical
scavenger ameliorates the vascular disorders in diabetes"
Prevents Hypertension and Increases Exercise Capacity in Rats With
Fructose-Induced Hypertension - Am J Hypertens. 2011 Feb 3 -
"Five groups of 15 Sprague-Dawley rats were allocated
and designated as control, high fructose-fed (fructose), high fructose-fed plus
exercise (FE), high fructose-fed plus 2% taurine supplement (FT) and high
fructose-fed plus 2% taurine supplement and exercise (FET) groups ...
Noninvasive SBP differed significantly (P < 0.001) from week 3, both noninvasive
and invasive ABP increased significantly (P < 0.001), and exercise capacity
significantly decreased (P < 0.001) in the fructose group compared with the
control group. The individual effects of swimming and taurine supplementation
were incapable of preventing the development of hypertension and SBP
significantly (P < 0.001) increased in the FE and FT groups; exercise capacity
in those groups remained similar to control. The combined effects of exercise
and taurine alleviated hypertension and significantly increased exercise
capacity in the FET group. Insulin resistance increased significantly and plasma
nitric oxide (NO) decreased significantly in the F, FE, and FT groups. Both
parameters remained similar to control values in the FET group with an
increasing antioxidant activity. Conclusion Taurine supplementation in
combination with exercise prevents hypertension and increases exercise capacity
by possibly antioxidation and maintaining NO concentrations"
Effects of Taurine on Development of Hepatic Steatosis Induced by a
High-Fat/Cholesterol Dietary Habit - J Agric Food Chem. 2010 Dec 2 -
"Nonalcoholic fatty liver (NAFL) is also called hepatic
steatosis and has become an emergent liver disease in developed and developing
nations ... taurine (Tau) ... Tau shows preventive effects on the development of
hepatic steatosis induced by a high-fat/cholesterol dietary habit"
prevents free fatty acid-induced hepatic insulin resistance in association with
inhibiting JNK1 activation and improving insulin signaling in vivo -
Diabetes Res Clin Pract. 2010 Sep 18 - "intralipid plus
heparin (IH) ... Taurine co-infusion with IH prevented the rise in
8-isoprostaglandin and MDA, inhibited the activation of JNK1, and improved
insulin signaling and insulin resistance in liver. The present study has
demonstrated that taurine, as an antioxidant, prevented hepatic oxidative stress
and ameliorated hepatic insulin resistance. And this effect may be associated
with the inhibition of JNK1 activation and the improvement of insulin signaling.
This study suggests the therapeutic value of taurine in protecting from hepatic
insulin resistance caused by elevated FFAs"
Beneficial Effects of Taurine on Cardiac Abnormality in NZB/W F1 Mice Fed
with a High-Cholesterol Diet J Agric Food Chem. 2009 Aug 14 -
"Improved cardiac histopathological changes were
observed in left ventricle tissues from the cholesterol/taurine group as
compared to the control or cholesterol group. Significant reductions of
TUNEL-positive cells, Fas death receptor-related components,
mitochondrial-dependent apoptosis, cardiac fibrosis, and fibrotic signaling
components were detected in the left ventricle tissues from the
cholesterol/taurine group as compared to the control or cholesterol group.
Additionally, cardiac IGR1R survival signaling components were significantly
increased in the left ventricle tissues from the cholesterol/taurine group
as compared to the control or cholesterol group. These findings revealed the
protective effects of taurine against the cardiac abnormalities in NZB/W F1
mice and may suggest the potential for clinical application of taurine in
treatment of CVD in SLE" - See
taurine at Amazon.com.
reduces the secretion of apolipoprotein B100 and lipids in HepG2 cells -
Lipids Health Dis. 2008 Oct 17;7(1):38 - "Higher
concentrations of serum lipids and apolipoprotein B100 (apoB) are major
individual risk factors of atherosclerosis and coronary heart disease ...
The results demonstrated that an addition of taurine to the culture media
reduces triacylglycerol (TG)-mass in the cells and the medium. Similarly,
cellular cholesterol-mass was decreased. Taurine inhibited the incorporation
of [14C] oleate into cellular and medium TG, suggesting the inhibition of TG
synthesis. In addition, taurine reduced the synthesis of cellular
cholesterol ester and its secretion, suggesting the inhibition of
acyl-coenzyme A:cholesterol acyltransferase activity. Furthermore, taurine
reduced the secretion of apoB, which is a major protein component of very
low-density lipoprotein ... This is a first report to demonstrate that
taurine inhibits the secretion of apoB from HepG2 cells"
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