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Home > Anti-aging Research > trehalose

Trehalose

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  • Natural sugar defends against metabolic syndrome, in mice - Science Daily, 8/23/18 - "a natural sugar called trehalose blocks glucose from the liver and activates a gene that boosts insulin sensitivity, reducing the chance of developing diabetes. Activating the gene also triggers an increase in calories burned, reduces fat accumulation and weight gain, and lessens measures of fats and cholesterol in the blood ... In mice, this gene is turned on as part of what seems to be the normal fasting response. Our data suggest that fasting -- or giving trehalose with a normal diet -- triggers the liver to change the way it processes nutrients, in a beneficial way. And if glucose can be blocked from the liver with a drug, it may be possible to reap the benefits of fasting without strictly limiting food ... Aloxe3 in the liver -- whether activated by fasting or trehalose -- leads the mice not only to make better use of insulin, but to increase calorie burning, raise body temperature, reduce weight gain and fat accumulation -- including fat deposits in the liver -- and lessen measures of fats and cholesterol in the blood. Further, they found that mice fed an obesity-inducing diet and mice that eat freely and are genetically prone to obesity are protected from metabolic disease if given trehalose in their drinking water ... activating Aloxe3 in the mice given trehalose improves insulin sensitivity in a way that is similar to how thiazolidinediones work" - See trehalose at Amazon.com.
  • Type of sugar may treat atherosclerosis, mouse study shows - Science Daily, 6/7/17 - "a natural sugar called trehalose revs up the immune system's cellular housekeeping abilities. These souped-up housecleaners then are able to reduce atherosclerotic plaque that has built up inside arteries. Such plaques are a hallmark of cardiovascular disease and lead to an increased risk of heart attack"
  • Natural sugar may treat fatty liver disease - Science Daily, 2/23/16 - "a natural sugar called trehalose prevents the sugar fructose -- thought to be a major contributor to nonalcoholic fatty liver disease -- from entering the liver and triggers a cellular housekeeping process that cleans up excess fat buildup inside liver cells ... In general, if you feed a mouse a high-sugar diet, it gets a fatty liver ... We found that if you feed a mouse a diet high in fructose plus provide drinking water that contains three percent trehalose, you completely block the development of a fatty liver. Those mice also had lower body weights at the end of the study and lower levels of circulating cholesterol, fatty acids and triglycerides ... Trehalose is a natural sugar found in plants and insects ... We know the mice that received drinking water with three percent trehalose lost weight, and we suspect that weight loss was due to loss of fat, but we can't be certain that's the only effect"