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Anti-aging Research > TMG
Trimethylglycine or Dimethylglycine
News & Research:
Performance Enhancer Discovered in the Nutrient Betaine - Science Daily,
7/5/13 - "betaine -- a nutrient found in shellfish and
beets -- boosts athletic performance by nearly six percent when added to a
sports drink ... Betaine may contribute to creatine synthesis, which improves,
strength, power and short-term performance ... researchers suggest: Dissolve 2.5
grams of betaine (either powder or tablet form) in a 20-ounce sports drink, and
drink half in the morning and half in the afternoon" - See
trimethylglycine at Amazon.com.
Danisco extends betaine’s sport science - Nutra USA, 8/13/09 -
"During various power, muscle endurance and
anaerobic power exercise tests over a two week period, subjects given
BetaPower showed a significant improvement in lower body muscle endurance
and quality of the workout compared to those participants that were not
given supplementation" - [Abstract]
New Findings About Homocysteine - Life Extension Magazine, 11/03 -
"a startling 100% of French elderly hospitalized
patients showed higher than desired
homocysteine levels, with 45% suffering from severe hyperhomocysteinemia
... Administration of vitamins B6 and B12, and folate, causes a significant
decrease of elevated serum homocysteine concentrations in older persons ...
More recent studies not only confirm the cardiovascular dangers of
homocysteine, but also its toxic effect on the brain. It turns out that high
blood levels of homocysteine increase the incidence of depression, memory
impairment, and even Alzheimer’s disease"
The Benefits of
CLA Too Good To Be True? - Life Extension Magazine, 6/99 -
"TMG may be one of the most important nutrients to
prevent heart disease, stroke, liver disease, slow aging and treat
depression. TMG is also called glycine betaine, but the name
"trimethylglycine" signifies that it has three methyl groups attached to
each molecule of glycine. In the body, TMG donates one of its methyl groups
to cellular DNA, which may help protect DNA against damage and its
consequences, cancer and premature aging. When a TMG methyl group is donated
to a molecule of homocysteine, it is converted first to methionine then to
s-adenosyl-methionine (SAM). No "safe" level of homocysteine has been
established, suggesting that taking nutrients like TMG could lower
everyone's risk of heart attack and stroke, in addition to protecting DNA."
SAMe Needs The B's - Nutrition Science News, 7/00 -
"users of this wonder pill should be aware that
through the natural metabolism of SAMe, the amino acid homocysteine is
created--a situation that can lead to artery damage and even heart disease.
. . . .others have demonstrated that by simply upping one's intake of the
vitamins B6, B12 and folic acid, this potential hazard can be avoided."
(Note: TMG is a precursor to SAM-e and lowers homocysteine instead of
Supplements, Exercise and Sauna - Life Extension Magazine, 9/99 -
"TMG, on the other hand, is very effective at
raising the levels of SAMe and lowering homocysteine."
- Dimethylglycine ,
dimethylglycine research, dimethylglycine benefits - Dr. Sahelian
Effects of betaine on body composition, performance, and homocysteine
thiolactone - J Int Soc Sports Nutr. 2013 Aug 22;10(1):39 -
"Twenty-three subjects were matched for training
experience (4.8 +/- 2.3 years) and body fat percentage (BF%: 16.9 +/- 8.0%),
randomly assigned to either a placebo (PL; n = 12) or betaine group (BET; n
= 11; 2.5 g/day), and completed a 6 week periodized training program
consisting of 3 two-week micro-cycles ... Six-weeks of betaine
supplementation improved body composition, arm size, bench press work
capacity, attenuated the rise in urinary HCTL, and tended to improve power
(p = .07) but not strength" - See
trimethylglycine at Amazon.com.
Betaine supplement alleviates hepatic triglyceride accumulation of
apolipoprotein E deficient mice via reducing methylation of peroxisomal
proliferator-activated receptor alpha promoter - Lipids Health Dis. 2013
Mar 13;12(1):34 - "Our findings indicate that
betaine supplement could alleviate hepatic triglyceride accumulation and
improve antioxidant capacity by decreasing PPAR alpha promoter methylation
and upregulating PPAR alpha and its target genes mRNA expression"
Effect of betaine supplementation on power performance and fatigue - J
Int Soc Sports Nutr. 2009 Feb 27;6:7 - "Subjects
were tested prior to the onset of supplementation (T1) and 7 (T2) and 14
days (T3) following supplementation ... No differences were seen at T2 or T3
in the repetitions performed to exhaustion or in the number of repetitions
performed at 90% of both peak and mean power between the groups in the bench
press exercise. The number of repetitions performed in the squat exercise
for BET was significantly greater (p < 0.05) than that seen for PL at T2.
The number of repetitions performed at 90% or greater of peak power in the
squat exercise was significantly greater for BET at both T2 and T3 than PL"
The association between betaine and choline intakes and the plasma
concentrations of homocysteine in women - Am J Clin Nutr. 2007
Oct;86(4):1073-1081 - "Total choline + betaine
intake was inversely associated with tHcy, as was choline from 2
water-soluble choline-containing compounds. Remethylation of tHcy may be
more dependent on the betaine pathway when methyl sources are low as a
result of either inadequate folate intake or heavier alcohol consumption"
The effect of low doses of betaine on plasma homocysteine in healthy
volunteers - Br J Nutr. 2004 Oct;92(4):665-9 -
tHcy is lowered
rapidly and significantly by 3 or 6 g betaine/d in healthy men and women"
Betaine in human nutrition - Am J Clin Nutr. 2004 Sep;80(3):539-549 -
"The growing body of evidence shows that betaine is
an important nutrient for the prevention of chronic disease"
Low Dose Betaine Supplementation Leads to Immediate and Long Term Lowering
of Plasma Homocysteine in Healthy Men and Women - J. Nutr.
133:4135-4138, December 2003 -
"doses of betaine in the range of dietary intake
reduce fasting and postmethionine loading plasma
homocysteine concentrations. A betaine-rich diet might therefore lower
cardiovascular disease risk"
Betaine Supplementation Lowers Plasma Homocysteine in Healthy Men and Women
- J. Nutr. 133:1291-1295, May 2003 -
"Groups of twelve subjects ingested 6 g betaine, 800
µg folic acid with 6 g placebo or 6 g placebo
each day for 6 wk ... Fasting plasma
homocysteine decreased by 1.8 µmol/L ... in the betaine group and by 2.7
µmol/L ... in the folic acid group ... betaine suppressed the total area
under the plasma homocysteine-time curve after methionine loading by 221
µmol . 24 h/L ... compared with placebo, whereas folic acid had no effect"
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