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Home > Anti-aging research > Phenylalanine


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News & Research:

  • Drug May Obviate Dietary Restriction for Hyperphenylalaninemia - Medscape, 12/26/02
  • I have had lower back pain since 1973. Do you have any suggestions? - Life Extension Magazine, 3/02
  • Exercise Levels Of Phenylethylamine May Damp Depression - Doctor's Guide, 9/27/01 - "Administration of phenylethylamine or its precursor L-phenylalanine, in conjunction with selegiline, a selective monoamine oxidase B inhibitor, has been reported to alleviate depression and to produce improvements in mood. The effects are sustained and also apparent in some patients who are insensitive to conventional treatment"
  • Amino Acids anyone? - DrBob.org - "L-phenylalanine can also be converted (through a separate pathway) to phenylethylamine, a substance that occurs naturally in the brain and appears to elevate mood." See my phenylethylamine page.
  • When It Comes to Love, the Nose Knows - WebMD, 2/14/01- "I believe that PEA (phenylethylamine) may be the hormone of libido"
  • Catecholamines Kick Out the Demons of Depression - Life Enhancement Magazine, 7/99
  • Natural Remedies for Depression - Nutrition Science News, 2/99 - "D-phenylalanine, which does not normally occur in the body or in food, is metabolized to phenylethylamine (PEA), an amphetaminelike compound that occurs normally in the human brain and has been shown to have mood-elevating effects. Decreased urinary levels of PEA (suggesting a deficiency) have been found in some depressed patients. Although PEA can be synthesized from L-phenylalanine, a large proportion of this amino acid is preferentially converted to L-tyrosine. D-phenylalanine is therefore the preferred substrate for increasing the synthesis of PEA--although L-phenylalanine would also have a mild antidepressant effect because of its conversion to L-tyrosine and its partial conversion to PEA. Because D-phenylalanine is not widely available, the mixture D,L-phenylalanine is often used when an antidepressant effect is desired"


  • Reduction of Brain Dopamine Concentration With Dietary Tyrosine Plus Phenylalanine Depletion - Am J Psychiatry. 2003 Oct;160(10):1887-9 - "Healthy male subjects were scanned on two occasions: once after receiving a balanced amino acid drink and once after receiving a drink mixture from which tyrosine and phenylalanine were omitted ... Dietary tyrosine and phenylalanine depletion increased [11C]raclopride binding in the striatum by a mean of 6%. The change in [11C]raclopride binding correlated significantly with the fall in the ratio of tyrosine and phenylalanine to large neutral amino acids"

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