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Return to cortisol page

Effects of Remeron (mirtazapine) on cortisol

I went to the library and tracked down the data in the "Effects of mirtazapine on growth hormone, prolactin, and cortisol secretion in healthy male subjects" study.  In brief, they took 18 healthy 20 to 35 year old males.  They drew blood samples one hour prior.  At time zero, they took a blood sample and gave either 15 mg of mirtazapine or a placebo and took blood samples again every 30 minutes out to 240 minutes.  -60 was at 8 AM.  Below is the table and graph of the results.

I felt that cortisol of placebo patient #1 was out of the norm.  The yellow line on the graph represents the results not counting that patient.

  Time (minutes) - (-60 is 8 AM)
  -60 0 30 60 90 120 150 180 210 240

Patient
Number


Cortisol ug/100ml after mirtazapine (15 mg orally)

1 24.69 15.41 12.98 9.85 8.53 6.53 5.62 4.78 4.03 3.33
2 24.11 14.25 10.40 8.88 7.57 6.02 5.27 4.29 4.39 3.75
3 29.23 21.26 14.74 9.68 6.88 5.38 3.84 3.65 4.46 6.50
4 14.18 8.20 9.39 7.11 5.13 4.43 3.59 3.16 7.95 4.41
5 16.94 16.62 11.04 8.48 5.74 4.83 4.12 3.49 4.91 4.64
6 14.73 8.22 8.57 5.92 4.05 3.55 3.07 2.18 2.08 1.94
7 18.01 11.85 10.33 8.27 5.93 5.31 11.64 7.39 5.92 5.10
8 11.30 8.88 7.22 5.95 4.52 3.79 3.18 2.45 2.71 2.14
Mean 19.15 13.09 10.58 8.02 6.04 4.98 5.04 3.92 4.56 3.98
 


Cortisol ug/100ml after placebo

1 38.24 24.56 20.14 19.64 19.06 18.87 16.19 14.00 13.64 12.34
2 28.68 15.02 13.18 11.34 9.87 10.28 11.98 12.49 11.77 11.54
3 23.44 15.10 12.82 12.99 11.82 9.29 11.08 9.33 10.47 7.90
4 18.86 13.07 12.40 11.08 8.77 7.58 6.91 13.75 15.49 13.19
5 13.80 9.71 7.96 8.95 6.24 6.38 5.59 6.54 5.79 6.81
6 24.90 16.32 13.22 15.18 17.52 15.69 13.14 13.06 12.11 10.08
7 18.31 15.10 12.06 11.39 10.39 10.59 10.79 9.25 9.39 10.81
8 10.19 7.18 6.36 4.78 5.77 8.46 9.14 7.25 5.83 8.48
Mean 22.05 14.51 12.27 11.92 11.18 10.39 10.00 10.58 10.56 10.14

Cortisol ug/100ml after placebo not counting placebo patient #1
Mean 19.74 13.07 11.14 10.82 10.05 9.75 9.80 10.10 10.12 9.83

Related Study: