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Home > Health Conditions > Di-indolylmethane
Di-indolylmethane
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News & Research:
- DIM and Cancer -
natmedonline.com
-
Compound In Broccoli Could Boost Immune System, Says Study - Science
Daily, 8/20/07 - "This study shows that there is a
whole new universe of cancer regulation related to DIM ... There are
virtually no other agents known that can both directly shut down the growth
of cancer cells and enhance the function of the immune system at the same
time"
-
Broccoli, soy anti-cancer benefits suggested - Nutra USA, 4/16/07 -
"this attraction between CXCR4 and
CXCL12 draws cancer cells to the organs they spread to ... exposure with
either DIM or genistein cut movement by 80 per cent"
-
I3C & DIM - Natural, Dual-Action Protection Against Deadly Cancers
- Life Extension Magazine, 1/06 - "Mounting preclinical and clinical evidence indicate[s] that indole-3-carbinol
(I3C), a key bio-active food component in cruciferous vegetables, has multiple
anticarcinogenic and antitumorigenic properties" - See
I3C products at iHerb
 .
-
I
have read that Indole-3-Carbinol (I3C) actually increases the activity of aromatase enzyme and that DIM does not - Life Extension Magazine, 3/01 -
"In one study, men received I3C for one week; a profile of 13 estrogens was
measured. The results were that I3C significantly increased the urinary excretion of C-2 estrogens. The urinary concentrations of nearly all other estrogen metabolites, including levels of estradiol, estrone, estriol and 16 alpha-hydroxyestrone, were lower after I3C treatment [J Natl Cancer Inst 1997 May
21;89(10):718-23]. On the other hand, studies have shown that DIM can actually induce aromatase activity with a two-fold increase [Toxicol Sci 2001 May;61(1):40-8]" - The following are the two
references for that statement:
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Diindolylmethanes Differentially Induce Cytochrome P450 1A1, 1B1, and 19 in H295R Human Adrenocortical Carcinoma Cells - Toxicol Sci 2001
May;61(1):40-8 - "DIM, but not TCDD, induced aromatase activity with an apparently maximal 2-fold increase at 10 µM; higher concentrations of DIM and many of its analogs were cytotoxic"
- Changes in levels of urinary estrogen metabolites after oral indole-3- carbinol treatment in humans - J Natl Cancer Inst 1997 May 21;89(10):718-23 -
"In both men and women, I3C significantly increased the urinary excretion of C-2 estrogens. The urinary concentrations of nearly all other estrogen metabolites, including levels of estradiol, estrone, estriol, and 16alpha- hydroxyestrone, were lower after I3C treatment"
- So if C-2 estrogens are increased, is that bad in men? I don't know. The following are all I could find:
- Estrogen Metabolism - immunacare.com -
"C-2 metabolites are essentially devoid of peripheral biological activity, as shown in studies on uterine weight, gonadotrophin
secretion, and cell proliferation {1}. 2-Hydroxyestrogen has even been found to exert a modest anti-estrogenic effect {2,3}, and has been called "the good estrogen" {4}. The 16a-hydroxylated metabolites, 16a-hydroxyestrone (16OHE1) and estriol
(E3), are estrogen agonists {5}."
- Effects of Pesticides on the Ratio of 16/2-Hydroxyestrone: A Biologic Marker of Breast Cancer Risk - Environmental Health Perspectives 103, Supplement 7, October 1995 -"Estradiol
metabolism proceeds by hydroxylation at one of two mutually exclusive sites at C-2 and C-16. The catechol pathway yields the weakly estrogenic 2-hydroxyestrone (2-OHE1), which inhibits breast cell
proliferation" - If that means, and I think it does, that the C-2 metabolites inhibit breast cell growth, that would definitely be a good thing for men.
-
I3C
vs DIM - Life Extension Foundation, 1/02
- Natural estrogen replacement article by Jonathan Wright MD. - IAS -
"DIM may reduce prostate cancer incidence
as it has been shown to stop human cancer cells from growing by (54-61%) and provoking the cells to self-destruct (apoptosis). DIM also improves prostate function, enhances insulin sensitivity and increases abdominal fat loss."
- I3C and DIM: Keys to Cancer Prevention? - Nutrition Science News, 4/01 -
"Increased 16-alpha-hydroxyestrone production has been
linked to an increase in breast cancer. Based on estrogen metabolism's influence on breast-cancer risk, researchers speculate that reducing hydroxylation of estrone's 16th carbon and increasing hydroxylation of the second carbon would be a wise, protective measure ... The minimum effective dose to increase the ratio
of 2-hydroxyestrone to 16-alpha-hydroxyestrone was 300 mg/day ... Most of the research thus far has focused on I3C, a phytonutrient converted by stomach acid to DIM, indolylcarbazole, and other metabolites ... A 350500 mg dose of I3C is roughly equal to 300500 mg of raw cabbage or brussels sprouts or about 3 cups
of broccoli"
- I've heard quite a bit about a broccoli extract called indole-3-carbinol (I3C). What is the difference between it and the other broccoli extract called diindolylmethane (DIM)? - Nutrition Science News, 2/01 -
"Certainly DIM by itself has an effect, but these other products may also be important for the overall cancer-inhibiting action. As most of the research to date has focused on I3C, it seems prudent at this time to use supplements containing I3C instead
of DIM"
- The Cruciferous Choice: DIM or I3C? - Michael A. Zeligs, M.D. -
"It is well documented that estrogen accumulates in the prostate gland starting at age 50 (42) and that estrogen
is associated with the degree of prostate enlargement ... Using DIM in men avoids accelerating testosterone metabolism, especially regarding unwanted conversion of testosterone into estrogen. In the safety study reported (11), I3C and not DIM increased activity of "aromatase" (CYP19), the enzyme responsible for
converting testosterone into estrogen"
- DIM FAQ - "DIM helps to eliminate active estrogen from the male body by promoting its conversion into the "good" metabolites. These metabolites then free up testosterone by bumping it off the testosterone-binding proteins.
The end result is a healthier balance of testosterone to estrogen and more free testosterone circulating in the body. In scientific studies, high levels of testosterone and low levels of estrogen have been linked to lean body mass, an efficient fat-burning metabolism, and low abdominal obesity. Other benefits from
testosterone are improved mood, more interest in sex, and better physical conditioning. In this chapter, we'll explore these issues in more detail."
- Di-indolylmethane - Jonathan Wright MD's, International Anti-aging Systems
- Reducing the Hormone Related Cancer Risk (Or cabbages, sex hormones and their metabolites) - Jonathan Wright M.D., International Anti-aging Systems -
"Among other things, estradiol is
metabolized into estrone, which in turn can be metabolized into either 2-hydroxyestrone or 16 alpha-hydroxyestrone. Importantly, there's an “inverse” relationship here: if more 2-hydroxyestrone is made, less 16 alpha-hydroxyestrone is usually made, and vice-versa. In at least one of his publications, Dr. Bradlow has
termed 2-hydroxyestrone “good estrogen”, and has given us evidence that 16 alpha hydroxyestrone is “bad estrogen”. He writes: “Evidence from a long series of studies has demonstrated a specific role for 16a-hydroxyestrone as a transforming estrogen, which is more potent than estradiol itself.” (“Transforming” refers
to the tendency of 16a-hydroxyestrone to increase cellular growth and proliferation, and even cancerous transformation in estrogen-responsive tissues). He goes on to note that the preponderance of evidence shows that, by contrast, 2-hydroxyestrone is non-carcinogenic or even anti-carcinogenic. He also notes that
treatment which reduces the 2/16a hydroxyestrone ratio has been shown to reverse the growth of human larygneal papillomas, caused by the same family of viruses (HPV) implicated in cervical cancers. Other researchers hypothesize that cancer in other tissues, including uterus, prostate, liver and kidney, may be
affected by the 2/16a hydroxyestrone ratio as well as other estrogen metabolites"
- Estrogen Levels Linked To Head And Neck Cancers - Doctor's Guide, 9/28/99 -
"Similar effects (to alter estrogen metabolic pathways) could be exerted by vegetables including broccoli and cauliflower, which
contain the phytochemical compound indole-3-carbinol."
- I3C/DIM - Recurrent Respiratory Papillomatosis Foundation
Abstracts:
-
B-DIM Impairs Radiation-Induced Survival Pathways Independently of
Androgen Receptor Expression and Augments Radiation Efficacy in
Prostate Cancer - Cancer Lett. 2011 Dec 9 -
"Increased consumption of cruciferous
vegetables is associated with decreased risk in prostate cancer (PCa).
The active compound in cruciferous vegetables appears to be the self
dimerized product [3,3'-diindolylmethane (DIM)] of indole-3-carbinol
(I3C). Nutritional grade B-DIM (absorption-enhanced) has proven safe
in a Phase I trial in PCa ... B-DIM inhibited cell growth in a
dose-dependent manner in both PC-3 (AR-) and C4-2B (AR+) cell lines.
B-DIM was effective at increasing radiation-induced cell killing in
both cell lines, independently of AR expression. B-DIM inhibited
NF-κB and HIF-1α DNA activities and blocked radiation-induced
activation of these transcription factors in both PC-3 and C4-2B
cells. In C4-2B (AR+) cells, AR expression and nuclear localization
were significantly increased by radiation. However, B-DIM abrogated
the radiation-induced AR increased expression and trafficking to the
nucleus, which was consistent with decreased PSA secretion. In vivo,
treatment of PC-3 prostate tumors in nude mice with B-DIM and
radiation resulted in significant primary tumor growth inhibition
and control of metastasis to para-aortic lymph nodes. These studies
demonstrate that B-DIM augments radiation-induced cell killing and
tumor growth inhibition. B-DIM impairs critical survival signaling
pathways activated by radiation, leading to enhanced cell killing.
These novel observations suggest that B-DIM could be used as a safe
compound to enhance the efficacy of radiotherapy for
castrate-resistant PCa"
-
CXCR4 and
CXCL12 down-regulation: A novel mechanism for the chemoprotection of
3,3'-diindolylmethane for breast and ovarian cancers - Cancer
Lett. 2008 Mar 28 - "Our data suggest that
one mechanism whereby DIM protects against breast, ovarian, and
possibly other cancers is through the repression of CXCR4 and/or
CXCL12, thereby lowering the invasive and metastatic potential of
these cells"
-
Indole-3-carbinol as a chemopreventive and anti-cancer agent -
Cancer Lett. 2008 Feb 29 -
"Indole-3-carbinol and its metabolite 3,3'-diindoylmethane (DIM)
target multiple aspects of cancer cell-cycle regulation and survival
including Akt-NFkappaB signaling, caspase activation, cyclin-dependent
kinase activities, estrogen metabolism, estrogen receptor signaling,
endoplasmic reticulum stress, and BRCA gene expression. This broad
spectrum of anti-tumor activities in conjunction with low toxicity
underscores the translational value of indole-3-carbinol and its
metabolites in cancer prevention/therapy. Furthermore, novel
anti-tumor agents with overlapping underlying mechanisms have
emerged via structural optimization of indole-3-carbinol and DIM,
which may provide considerable therapeutic advantages over the
parental compounds with respect to chemical stability and anti-tumor
potency. Together, these agents might foster new strategies for
cancer prevention and therapy"
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