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Home > Anti-aging Research > Prolactin
Prolactin
Specific Recommendations (to lower prolactin):
Alternative News:
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Acute effects of LI 160 (extract of Hypericum perforatum, St John's wort) and two of its constituents on neuroendocrine responses in the rat -
J Psychopharmacol. 2000;14(4):360-3 - "LI 160 also lowered plasma prolactin and prevented the increase in plasma prolactin following haloperidol administration"
- Saving Yourself from AGE - Life Enhancement Magazine, 8/00 - with American Ginseng,
"The researchers found a reduction in plasma prolactin, a hormone connected with passive "nesting"
behavior, suggesting that this may play a role in the ability of American ginseng to stimulate sexual activity in the male rat."
- Make Spring Come Sooner - Life Enhancement Magazine, 4/98 -
"After administration of 5-HTP, the cortisol level significantly increased and the prolactin level significantly decreased. High
levels of prolactin have been shown to reflect many depressive states."
-
5-HTP SeroTonic™ & 5-HTP Slim™ May Help Make Spring Come Sooner - Life Enhancement Magazine, 4/98 -
"High levels of prolactin
have been shown to reflect many depressive states ... 5-HTP reduces prolactin"
- Study 20 - The Hypericum Homepage - "Both serum-cortisol and serum-prolactin were lowered significantly after three weeks of treatment with hypericum extract in male rats."
- Pyridoxine (Vit. B6) decreases opioids-induced hyperprolactinemia -
Horm Metab Res. 1985 Jan;17(1):46-7
- Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise -
N Engl J Med. 1982 Aug 12;307(7):444-5
- Inhibition of prolactin by pyridoxine -
Am J Obstet Gynecol. 1979 Sep 15;135(2):280-1
- Effects of pyridoxine hydrochloride (vitamin B6) on chlorpromazine-induced serum prolactin rise in male rats - J Pharm Sci. 1979 Sep;68(9):1179-81 -
"Pyridoxine hydrochloride significantly suppressed the chlorpromazine-induced prolactin rise"
CME:
General Information:
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Hyperprolactinemia - American Academy of Family Physicians
- Hyperprolactinemia - emedicine.com
-
Hyperprolactinemia - FamilyDoctor.org
- Prolactin - colostate.edu -
"Excessive secretion of prolactin - hyperprolactinemia
- is a relative common disorder in humans ... Common manifestations of
hyperprolactinemia in women include amenorrhea (lack of menstrural cycles)
and galactorrhea (excessive or spontaneous secretion of milk). Men with
hyperprolactinemia typically show hypogonadism, with decreased sex drive,
decreased sperm production and impotence. Such men also often show breast
enlargement (gynecomastia), but very rarely produce milk."
-
American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Evaluation and Treatment of Male Sexual Dysfunction - aace.com -
"Libido problems may be related to hypogonadism, hyperprolactinemia, depression, fear of sexual failure, certain medications, or systemic illness ... increased prolactin levels may also result in erectile problems, even in the presence of a normal testosterone level ... Excessive consumption of
alcohol or use of other recreational drugs may cause sexual dysfunction, either by causing increased prolactin or decreased testosterone production (or both) ... Psychotropic agents may raise prolactin levels"
- Prolactin Excess - asrm.org -
"Bromocriptine
(Parlodel®) is the main drug used to treat prolactin excess. I works by suppressing prolactin production. The starting dosage is usually 1.25 to 2.5
mg nightly, with the dosage slowly increased until prolactin level return to the normal range"
- Patient's Fact Sheet: Prolactin Excess (.pdf format) - American Society for Reproductive Medicine -
"In men, hyperprolactinemia may be associated with impotence and can affect
fertility."
- Treatments for hyperprolactinemia
 - Medifocus.com
Other Information:
-
Bromocriptine (Parlodel®) - International Anti-aging Systems
-
Evaluation and Treatment of Male Sexual Dysfunction - American Association of Clinical Endocrinologists and The American College of Endocrinology -
"increased prolactin levels may also
cause erectile problems, even in the presence of a normal testosterone level."
- Erectile Dysfunction / Impotence - Prostate Health Guide - U. of Maryland Medicine -
"Hormonal abnormalities such as increased prolactin (a hormone produced by the anterior pituitary
gland), steroid abuse by body-builders, too much or too little thyroid hormone, and hormones administered for prostate cancer may cause impotence. Rarely is low testosterone responsible for impotence"
-
Hormone Prolactin Reduces Fat Metabolism - Science Daily, 4/2/09
-
Aripiprazole Reverses
Antipsychotic-Induced Hyperprolactinemia - Medscape, 10/1/07
-
Antipsychotic Treatment: When to Measure Prolactin - Clinical Psychiatry
News, 5/05
-
Antipsychotic Medications Vary In Effect On Plasma Prolactin Levels - Doctor's Guide, 2/10/04
-
Cabergoline May Be Safely Withdrawn From Select Patients With Hyperprolactinomas - Doctor's Guide, 11/21/03
-
Aripiprazole Benefits Are Sustained Over Time - Clinical Psychiatry News, 5/03 -
"Its principal
advantage over other atypical agents remains a superior side effect profile; no apparent difference in efficacy exists ... It's not the new clozapine (Clozaril) ... it seems clearly superior in areas that have been problematic, notably weight gain, effects on blood lipids and glucose, and prolactin elevation ... in
fact, they lost weight overall, with the heaviest patients losing most ... Pooled data from short-term clinical studies showed a mean decline of 57% in serum prolactin"
-
Prolactin Not A Pro-Inflammatory In Polymyalgia Rheumatica - Doctor's Guide, 4/26/02
- Antipsychotic-Induced Hyperprolactinemia May Have Reproductive And Other Clinical Morbidities - Doctor's Guide, 8/8/01
-
Elevated
Prolactin Linked To Breast Cancer - Life Extension Magazine, 6/99
- Laboratory Investigations of Erectile Dysfunction - WebMD
- Dostinex Launched for Pituitary Gland Disorders - Doctor's Guide, 3/18/97
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