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Anti-aging Research > Longevity
News & Research:
An Hour of Running May Add 7 Hours to Your Life - NYT, 4/12/17 -
"In concrete terms, an hour of running statistically
lengthens life expectancy by seven hours"
Astaxanthin compound found to switch on the FOX03 'Longevity Gene' in mice -
Science Daily, 3/28/17 -"The Astaxanthin compound
CDX-085 (developed by Cardax) showed the ability to significantly increase the
expression of the FOXO3 gene, which plays a proven role in longevity ... We
found a nearly 90% increase in the activation of the FOXO3 "Longevity Gene" in
the mice fed the higher dose of the Astaxanthin compound CDX-085" - See BioAstin at Amazon.com
Anti-Aging Effect of
Riboflavin Via Endogenous Antioxidant in Fruit fly Drosophila Melanogaster -
J Nutr Health Aging. 2017;21(3):314-31 - "Riboflavin
prolonged the lifespan and increased the reproduction of fruit flies through
anti-oxidative stress pathway involving enhancing the activity of SOD1 and CAT
and inhibiting LF accumulation. Riboflavin deserves more attention for slowing
human aging" - See riboflavin at
High-sugar diet programs a short lifespan in flies - Science Daily, 1/11/17
- "Flies with a history of eating a high sugar diet live
shorter lives, even after their diet improves. This is because the unhealthy
diet drives long-term reprogramming of gene expression ... The FOXO gene is
important for longevity in a wide variety of species, including yeast, flies,
worms and humans, so the team say the findings may have broad implications"
compound reduces signs of aging in healthy mice - Science Daily, 10/27/16 -
"With age, the body loses its capacity to make a key
element of energy production called NAD (nicotinamide adenine dinucleotide) ...
Past research also has shown that NAD is not effective when given directly to
mice so the researchers sought an indirect method to boost its levels. To do so,
they only had to look one step earlier in the NAD supply chain to a compound
called NMN (nicotinamide mononucleotide) ... NMN can be given safely to mice and
is found naturally in a number of foods, including broccoli, cabbage, cucumber,
edamame and avocado. The new study shows that when NMN is dissolved in drinking
water and given to mice, it appears in the bloodstream in less than three
minutes. Importantly, the researchers also found that NMN in the blood is
quickly converted to NAD in multiple tissues ... The researchers found a variety
of beneficial effects of NMN supplementation, including in skeletal muscle,
liver function, bone density, eye function, insulin sensitivity, immune
function, body weight and physical activity levels" - See
NMN (nicotinamide mononucleotide) at Amazon.com.
Activation of the
AMPK/Sirt1 pathway by a leucine-metformin combination increases insulin
sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism and
increases life span in Caenorhabditis elegans - Metabolism. 2016 Jul 9 -
"We have previously shown leucine (Leu) to activate
Sirt1 by lowering its KM for NAD+, thereby amplifying the effects of other
sirtuin activators and improving insulin sensitivity. Metformin (Met) converges
on this pathway both indirectly (via AMPK) and by direct activation of Sirt1 ...
Leu and Met synergize to enable Sirt1 activation at low NAD+ concentrations
(typical of energy replete states). Sirt1 and AMPK activations are required for
Met-Leu's full action, which result in improvements in energy metabolism and
insulin sensitivity" - See BulkSupplements Pure L-Leucine Powder (1 Kilogram)
Metformin at IAS.
Pomegranate finally reveals its powerful anti-aging secret - Science Daily,
7/11/16 - "The team started out by testing their hypothesis on the usual
suspect: the nematode C. elegans. It's a favorite test subject among aging
experts, because after just 8-10 days it's already considered elderly. The
lifespan of worms exposed to urolithin A increased by more than 45% compared
with the control group ...
These initial encouraging results led the team to test the molecule on animals
that have more in common with humans. In the rodent studies, like with C.
elegans, a significant reduction in the number of mitochondria was observed,
indicating that a robust cellular recycling process was taking place. Older
mice, around two years of age, showed 42% better endurance while running than
equally old mice in the control group" - See
pomegranate extract at Amazon.com.
Chlorogenic Acid Extends
the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway -
J Gerontol A Biol Sci Med Sci. 2016 Jul 4 - "Coffee and
tea, two of the most popular drinks around the world, share many in common from
chemical components to beneficial effects on human health. One of their shared
components, the polyphenols, most notably chlorogenic acid (CGA), was supposed
to account for many of the beneficial effects on ameliorating diseases occurred
accompanying people aging, such as the antioxidant effect and against diabetes
and cardiovascular disease ... We found that CGA could extend the lifespan of C.
elegans by up to 20.1%, delay the age-related decline of body movement, and
improve stress resistance" - See
chlorogenic acid at Amazon.com.
Fountain of youth? Dietary supplement may prevent and reverse severe damage to
aging brain, research suggests - Science Daily, 6/2/16 -
ingredients such as vitamins B, C and D, folic acid, green tea extract, cod
liver oil and other nutraceuticals ... The mice used in this study had
widespread loss of more than half of their brain cells, severely impacting
multiple regions of the brain by one year of age, the human equivalent of severe
Alzheimer's disease ... they also discovered that the mice on the supplements
experienced enhancement in vision and most remarkably in the sense of smell --
the loss of which is often associated with neurological disease -- improved
balance and motor activity" - See
Garden of Life Vitamin Code 50 & Wiser Men's Multi, 240 Capsules and
Garden of Life Vitamin Code 50 & Wiser Women's
Multi, 240 Capsules.
stops the aging process of organs - Science Daily, 4/28/16 -
"As mice, like all mammals, age, the regenerative
capacity of certain organs (such as the liver and kidneys) and muscles
(including the heart) diminishes. Their ability to repair them following an
injury is also affected. This leads to many of the disorders typical of aging
... We gave nicotinamide riboside to 2-year-old mice, which is an advanced age
for them ... This substance, which is close to vitamin B3, is a precursor of
NAD+, a molecule that plays a key role in mitochondrial activity. And our
results are extremely promising: muscular regeneration is much better in mice
that received NR, and they lived longer than the mice that didn't get it ...
Parallel studies have revealed a comparable effect on stem cells of the brain
and skin ... So far, no negative side effects have been observed following the
use of NR, even at high doses" - See
nicotinamide riboside at Amazon.com.
helps scientists unlock ageing puzzle - BBC News, 4/7/16 -
"fruit flies lived 16% longer than average when given
low doses of lithium ... At high doses, lithium reduced their lifespan ... We
found low doses not only prolong life but also shield the body from stress and
block fat production for flies on a high sugar diet" - See
lithium supplements at Amazon.com.
Scientific secrets for successful aging? - Science Daily, 3/29/16 -
"Now that these age-related metabolites have been
identified, the decline in antioxidants and muscle strength suggest that it is
important for individuals to consume foods high in antioxidants and to continue
exercising, especially after the age of 65. This could help increase the levels
of the related metabolites in the body and improve body conditions"
cream ingredient found to mimic life-extending effects of a calorie restriction
diet - Science Daily, 12/16/15 - "scientists have shown for the first time
that allantoin, which is found in botanical extracts of the comfrey plant and is
an ingredient of many anti-ageing creams, can mimic the effect of calorie
restriction and increase lifespan in worms by more than 20% ... worms treated
with allantoin, rapamycin, trichostatin A and LY-294002 not only lived longer,
but also stayed healthier longer. Additionally, when the same compounds were
tested in mutant worms they extended lifespan in a way expected from calorie
restriction" - See allantoin products at Amazon.com.
drug protects stem cells from aging - Science Daily, 12/17/15 -
"the drug zoledronate is able to extend the lifespan of
mesenchymal stem cells by reducing DNA damage ... DNA damage is one of the most
important mechanisms of aging where stem cells lose their ability to maintain
and repair the tissues in which they live and keep it working correctly"
acid activates daf-16 to increase lifespan in C.elegans - Biochem Biophys
Res Commun. 2015 Nov 16 - "We investigate here whether OA has an impact on
longevity in vivo, and more specifically, we have examined effects of OA on the
lifespan and stress tolerance in Caenorhabditis elegans (C.elegans). Our results
showed that OA could extend the lifespan, increase its stress resistance and
reduce the intracellular reactive oxygen species (ROS) in wild-type worms.
Moreover, we have found that OA-induced longevity may not be associated with the
calorie restriction (CR) mechanism" - See oleanolic acid at Amazon.com.
- Oleanolic acid
- wikipedia.org - "Oleanolic acid can be found in
olive oil, Phytolacca americana (American pokeweed), and Syzygium spp,
supplementation at lower doses increases oxidative stress resistance and
longevity in Caenorhabditis elegans - Age (Dordr). 2015 Dec;37(6):113 -
"Here, we show for first time that FA extends organism
life span and causes a delay in aging. We observed that FA inhibits mechanistic
target of rapamycin (mTOR) and insulin/insulin growth factor 1 (IGF-1) signaling
pathways to control both oxidative stress levels and life span. The expression
levels of stress- and life span-relevant gerontogenes, viz. daf-16, skn-1, and
sir. 2.1, and oxidative enzymes, such as glutathione S-transferase 4 (GST-4) and
superoxide dismutase 3 (SOD-3), were also found to be highly enhanced to
attenuate the intracellular reactive oxygen species (ROS) damage and to delay
the aging process. Our study promotes the use of FA to mitigate abiotic stresses
and other aging-related ailments" - See
folic acid products at Amazon.com.
Nutraceutical intervention reverses the negative effects of blood from aged rats
on stem cells - Age (Dordr). 2015 Oct - "Aging is
associated with a decline in function in many of the stem cell niches of the
body. An emerging body of literature suggests that one of the reasons for this
decline in function is due to cell non-autonomous influences on the niche from
the body ... We examined if we could reverse this effect of aged serum on stem
cell proliferation by treating aged rats with NT-020, a dietary supplement
containing blueberry, green tea, vitamin D3, and carnosine that has been shown
to increase neurogenesis in aged rats. Young and aged rats were administered
either control NIH-31 diet or one supplemented with NT-020 for 28 days, and
serum was collected upon euthanasia ... Serum from aged rats significantly
reduced cell proliferation as measured by the
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and
5-bromo-2'-deoxyuridine (BrdU) assays in both NPCs and MSCs. Serum from aged
rats treated with NT-020 was not different from serum from young rats.
Therefore, NT-020 rescued the effect of serum from aged rats to reduce stem cell
Are You Aging Faster Than Everyone Else? - NBC News, 7/7/15 -
"as early as age 38, some people are biologically much
older. In fact, some look like they're in their 60s, while others still look
like 20-somethings ... Some of the people in our cohort had aged physiologically
not at all between 26 and 38 ... At the other end of the extreme there were
folks aging two to three times as much ... Their scores on the tests looked like
people who are in their 50s and 60s ... The study members who appeared to be
aging faster in their physiologies were also doing less well on the physical
function ... We saw that already by age 38, study members whose physiologies
were aging faster were showing signs of cognitive decline ... Perhaps most
stunning, the aging-related changes showed up in people's faces"
improves putative longevity effectors in peripheral mononuclear cells from
subjects with prediabetes. A randomized controlled trial - Nutr Metab
Cardiovasc Dis. 2015 Mar 24 - "Compared to baseline,
metformin significantly improved metabolic parameters and insulin sensitivity,
increased SIRT1 gene/protein expression and SIRT1 promoter chromatin
accessibility, elevated mTOR gene expression with concomitant reduction in
p70S6K phosphorylation in subjects' PBMCs, and modified the plasma N-glycan
profile. Compared to placebo, metformin increased SIRT1 protein expression and
reduced p70S6K phosphorylation (a proxy of mTOR activity). Plasma N-glycans were
also favourably modified by metformin compared to placebo" - See
metformin at IAS.
replacement therapy and longevity - Andrologia. 2015 Apr 19 -
"It was found that testosterone replacement therapy of
men suffering from late onset hypogonadism increased survival rate by 9-10% in 5
years, similar to that of eugonadal, non-LOH men with normal endogenous
testosterone secretion. Oestrogen replacement therapy resulted in increased
survival by 2.6% in 5 years. It is concluded that hormone replacement therapy
metformin and aspirin on life history features and longevity of crickets:
trade-offs versus cost-free life extension? - Age (Dordr). 2015
Apr;37(2):9769 - "Both drugs significantly increased
survivorship and maximal life span. Maximal longevity was 136 days for controls,
188 days (138 % of controls) for metformin, and 194 days (143 % of controls) for
aspirin. Metformin and aspirin in combination extended longevity to a lesser
degree (163 days, 120 % of controls)" - See
metformin at IAS.
class of drugs dramatically increases healthy lifespan, mouse study suggests
- Science Daily, 3/9/15 - "like cancer cells, senescent
cells have increased expression of "pro-survival networks" that help them resist
apoptosis or programmed cell death. This finding provided key criteria to search
for potential drug candidates ... Using these criteria, the team homed in on two
available compounds -- the cancer drug dasatinib (sold under the trade name
Sprycel®) and quercetin, a natural compound sold as a supplement that acts as an
antihistamine and anti-inflammatory ... The two compounds had different strong
points. Dasatinib eliminated senescent human fat cell progenitors, while
quercetin was more effective against senescent human endothelial cells and mouse
bone marrow stem cells. A combination of the two was most effective overall ...
In animal models, the compounds improved cardiovascular function and exercise
endurance, reduced osteoporosis and frailty, and extended healthspan" -
quercetin at Amazon.com.
Ibuprofen Extends Life In Lab Species, Study Finds (Humans, Too?) - NBC
News.com, 12/18/14 - "The ibuprofen administered to test
subjects was comparable to recommended amounts for humans ... The treatments
gave the organisms roughly 15 percent more life — equal to about 12 human years"
ibuprofen at Amazon.com.
soda consumption, cell aging associated in new study - Science Daily,
10/16/14 - "Regular consumption of sugar-sweetened sodas
might influence disease development, not only by straining the body's metabolic
control of sugars, but also through accelerated cellular aging of tissues ...
Based on the way telomere length shortens on average with chronological age, the
UCSF researchers calculated that daily consumption of a 20-ounce soda was
associated with 4.6 years of additional biological aging. This effect on
telomere length is comparable to the effect of smoking, or to the effect of
regular exercise in the opposite, anti-aging direction"
Sense of Smell May Predict Longevity - NYTimes.com, 10/1/14 -
"people who could not detect the odors were more than
three times as likely to die within five years as those who could. The lower
their scores on the odor test, the more likely they were to die. Only severe
liver damage was a better predictor of death ... The researchers believe that
the decline in the ability to smell is an indicator of some other age-related
degeneration, and is not itself a cause of death"
enhances parental reproductive lifespan and progeny viability in Drosophila
melanogaster - Age (Dordr). 2014 Oct;36(5):9702 -
"We have used the well-established model organism, Drosophila melanogaster, and
ascertained the consequence of diet supplementation with curcumin. Flies reared
on curcumin-supplemented diet had significantly higher lifespan. The progeny of
flies reared on curcumin had a higher viability. The activity of a key
mitochondrial enzyme-aconitase was significantly higher in flies reared on
curcumin-supplemented diet. The results suggest that curcumin can not only
correct a key step in the citric acid cycle and help in the release of
additional energy but also permanently correct developmental and morphogenetic
processes" - See
curcumin products at Amazon.com.
Vitamin D: A Key to a Longer Life? - WebMD, 6/17/14 -
"The researchers examined eight studies from Europe and
the United States that together tracked more than 26,000 nonsmoking men and
women ... Those with the lowest levels of vitamin D were about 1.5 times more
likely than those with the highest levels to die from any cause and from heart
disease during the periods of the studies. Those with low levels of vitamin D
and a history of cancer were 1.7 times more likely to die of the disease ...
It's not clear how vitamin D could help people live longer, but it might have
something to do with the way it acts like a hormone" - See
vitamin D at Amazon.com.
Anti-diabetic drug slows aging and lengthens lifespan, animal study suggests
- Science Daily, 6/2/14 - "Metformin causes a slight
increase in the number of harmful oxygen molecules. We found that this makes
cells stronger and extends their healthy lifespan ... Other studies in humans
have shown that metformin suppresses some cancers and heart disease. Metformin
could even be an effective drug for counteracting the general effects of aging,
say the researchers" - [Abstract]
metformin at IAS.
to measure the speed of aging: Your handshake - Science Daily, 5/8/14 -
"hand grip corresponds to other markers of aging such as
people's future mortality, disability, cognitive decline and ability to recover
from hospital stays"
Top 3 Foods for a Longer Life - ABC News, 4/21/14 -
"resveratrol increases the activity of specific genes called sirtuins that
protect against diseases of aging by revving up the mitochondria, the little
batteries inside our cells ... mice fed the bacterial strain Bifidobacterium
animalis lactis lived longer and were healthier than mice that did not receive
the probiotic ... people who consume 650 mg a day of polyphenols live longer
than those who get less then that" - See
resveratrol products at Amazon.com
Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
adults: Build muscle and you'll live longer - Science Daily, 3/14/14 -
"The researchers analyzed data collected by the National
Health and Nutrition Examination Survey (NHANES) III, conducted between 1988 and
1994. They focused on a group of 3,659 individuals that included men who were 55
or older and women who were 65 or older at the time of the survey. The authors
then determined how many of those individuals had died from natural causes based
on a follow-up survey done in 2004 ... They found that all-cause mortality was
significantly lower in the fourth quartile of muscle mass index compared with
the first quartile"
Supplement added to standard diet improves health, prolongs life in mice -
Science Daily, 2/27/14 - "Activating a protein
called sirtuin 1 extends lifespan, delays the onset of age-related metabolic
diseases, and improves general health in mice ... tested the effects of a
small molecule that activates SIRT1, called SIRT1720, on the health and
lifespan of mice. The animals were fed a standard diet supplemented with 100
mg/kg SRT1720 beginning at 6 months of age for the remainder of their lives
... SRT1720 significantly extended the average lifespan of mice by 8.8%.
Supplementation also reduced body weight and body fat percentage, and it
improved muscle function and motor coordination throughout the animals'
- SRT1720 -
Wikipedia - "SRT1720 is a drug developed by Sirtris Pharmaceuticals
intended as a small-molecule activator of the sirtuin subtype SIRT1.
It has similar activity in the body to the known SIRT1 activator
resveratrol, but is 1000x more potent"
High Dietary Intake of Polyphenols Are Associated With Longevity -
Science Daily, 10/9/13 - "the first to evaluate the
total dietary polyphenol intake by using a nutritional biomarker and not
only a food frequency questionnaire ... Polyphenols have antioxidant,
antiinflammatory, anticarcinogenic, etc. effects ... based on a 12-year
follow-up of a population sample composed by 807 men and women aged 65 or
over from Greve and Bagno (Tuscany, Italy) ... the research proves that
overall mortality was reduced by 30% in participants who had rich-polyphenol
diets (>650 mg/day) in comparison with the participants who had
low-polyphenol intakes (<500 mg/day)" - See
Jarrow Formulas, OPCs + 95, 100 mg, 100 Capsules at iHerb.
- Pill linked to long
life in mice - BBC News, 7/31/13 - "Scientists
believe the drug, metformin, may mimic the effects of extreme calorie
restriction ... Metformin is one of the most widely prescribed treatments
for type-2 diabetes, which occurs mainly in people above the age of 40. It
is also used to treat metabolic syndrome, a combination of diabetes, high
blood pressure and obesity ... The scientists gave one of two different
doses of metformin to middle-aged male mice and found that lower doses
increased lifespan by about 5%, and also delayed the onset of age-associated
diseases" - Note: I've been taking it in low doses for years to help
combat aging. See
metformin at IAS.
Rate of aging may be determined in the womb and linked to birthweight, study
reveals - Science Daily, 7/9/13 - "a person's
weight at the time of birth is an important determinant of health in middle
and old age, and that people with low birth weight are more susceptible to
age related diseases"
Decreased Micronucleus Frequency in Human Lymphocytes after Folate and
Vitamin B12 Intervention: a Preliminary Study in a Yunnan Population -
Int J Vitam Nutr Res. 2012 Dec 1;82(6):374-382 -
"Micronucleus (MN) is a validated biomarker for DNA damage in peripheral
blood lymphocytes (PBL) and is a reflection of the changes of human
nutritional status. Folate (FA) and vitamin B12 are one-carbon
metabolism-related micronutrients, which play important roles in maintaining
genomic stability ... Dietary supplement intake of FA and B12 based on MTHFR
genotypes could protect the genome from damage and benefit genome health"
folic acid products at Amazon.com
vitamin B12 at Amazon.com.
Concentrations of a Urinary Biomarker of Polyphenol Intake Are Associated
with Decreased Mortality in Older Adults - J Nutr. 2013 Jun 26 -
"Polyphenols might have a role in the prevention of
several chronic diseases, but evaluating total dietary polyphenol (TDP)
intake from self-reported questionnaires is inaccurate and unreliable. A
promising alternative is to use total urinary polyphenol (TUP) concentration
as a proxy measure of intake. The current study evaluated the relationship
between TUPs and TDPs and all-cause mortality during a 12-y period among
older adult participants ... In the multivariable Cox model, participants in
the highest tertile of TUP at enrolment had a lower mortality rate than
those in the lowest tertile [HR = 0.70 (95% CI: 0.49-0.99); P-trend =
0.045], whereas no significant associations were found between TDP and
overall mortality. TUP is an independent risk factor for mortality among
community-dwelling older adults, suggesting that high dietary intake of
polyphenols may be associated with longevity" - See
Jarrow Formulas, OPCs + 95, 100 mg, 100 Capsules.
Herbal Extract Boosts Fruit Fly Lifespan by Nearly 25 Percent - Science
Daily, 6/18/13 - "Rhodiola works in a manner
completely unrelated to dietary restriction and affects different molecular
pathways ... Rhodiola can act even in individuals who are already long-lived
and healthy. This is quite unlike resveratrol, which appears to only act in
overfed or unhealthy individuals ... Not only did Rhodiola improve lifespan
an average of 24 percent in both sexes and multiple strains of flies, but it
also delayed the loss of physical performance in flies as they aged and even
extended the lives of old flies ... Rhodiola has already shown possible
health benefits in humans, such as decreasing fatigue, anxiety and
depression; boosting mood, memory and stamina; and preventing altitude
sickness" - See
Rhodiola rosea at Amazon.com.
Calcium Supplements Linked to Longer Lifespans in Women - Science Daily,
5/22/13 - "Researchers analyzing data from the
large-scale Canadian Multicentre Osteoporosis Study (CaMos) sought to
clarify this issue and found moderate doses of calcium supplements had a
beneficial effect in women ... The benefit was seen for women who took doses
of up to 1,000 mg per day, regardless of whether the supplement contained
vitamin D ... there was no statistical benefit for men ... the same benefits
were seen when the calcium came from dairy foods, non-dairy foods or
How diabetes drug delays aging in worms - Science Daily, 3/28/13 -
"Following a calorie-restricted diet has been shown
to improve health in later life and extend lifespan in a number of animals,
ranging from the simple worm to rhesus monkeys. The type 2 diabetes drug
metformin has been found to have similar effects in animals ... Overall,
treatment with metformin adds up to 6 days of life for the worm which is
equivalent to around a third of its normal lifespan. It seems to work by
altering metabolism in the bacteria that live in the worm, which in turn
limits the nutrients that are available to the worm host and has a similar
effect to restricting the diet ... However, when they added an excess of
sugar to the diet, the team found that the life-extending effects of
metformin were cancelled out" - See
metformin at IAS.
Anti-aging drug breakthrough - Science Daily, 3/8/13 -
"Drugs that combat aging may be available within
five years ... The target enzyme, SIRT1, is switched on naturally by calorie
restriction and exercise, but it can also be enhanced through activators.
The most common naturally-occurring activator is resveratrol, which is found
in small quantities in red wine, but synthetic activators with much stronger
activity are already being developed ... While any drug would be strictly
prescribed for certain conditions, Professor Sinclair suggests that one day,
they could be taken orally as a preventative ... overweight mice given
synthetic resveratrol were able to run twice as far as slim mice and they
lived 15 per cent longer" - Note: They've been saying that five year
thing ever since I've been reading health articles. In the mean time, see
resveratrol products at Amazon.com.
Boomers' Overall Health Worse Than Their Parents - Medscape, 2/4/13 -
"Despite their longer life expectancy over previous
generations, US baby boomers have higher rates of chronic disease, more
disability, and lower self-rated health than members of the previous
generation at the same age ... As to comparative disability, more than twice
as many baby boomers used walking assist devices (6.9% vs 3.3%), more were
limited in their work by disability (13.8% vs 10.1%), and 13.5% vs 8.8% were
coping with some type of functional limitation ... In addition, more baby
boomers are obese compared with the previous generation (38.7% vs 29.4%),
and they reported exercising significantly less often (35.0% vs 49.9%
exercised >12 times per month) ... Moderate drinking was more common among
the boomers compared with the previous generation (67.3% vs 37.2%) ...
Hypertension, too, was more common (43.0% vs 36.4%) ... the present study
demonstrates a clear need for policies that expand efforts at prevention and
healthy lifestyle promotion in the baby boomer generation"
Hydrogen sulfide: The next anti-aging agent? - Science Daily, 1/29/13 -
"Hydrogen sulfide* (H2S) may play a wide-ranging
role in staving off aging ... Hydrogen sulfide is produced within the human
body, and has a variety of important physiological effects. For example, it
relaxes the vascular endothelium and smooth muscle cells, which is important
to maintaining clean arteries as one ages ... It functions as an
antioxidant. And it inhibits expression of pro-inflammatory factors, all of
which "imply an important role in aging and age-associated diseases," ...
Produced in the kidneys, it has direct angiotensin-converting enzyme (ACE)
inhibiting activity; that is, it's an ACE inhibitor, just like certain drugs
that mitigate high blood pressure. Not surprisingly, plasma H2S declines
with age, and is lower in spontaneously hypertensive rats than in those with
normal blood pressure. More generally, a lack of H2S is implicated in
Healthy living adds fourteen years to your life, study suggests -
Science Daily, 11/5/12 - "researchers pulled data
from five different cohorts included in the Cardiovascular Lifetime Risk
Pooling Project and looked at the participants' risk of all forms of fatal
and nonfatal cardiovascular disease from ages 45, 55 and 65 through 95 years
of age ... Individuals with optimal risk factor profiles lived up to 14
years longer free of total CVD than individuals with at least two risk
factors ... Men in middle age had lifetime risks of approximately 60 percent
for developing cardiovascular disease ... Women in middle age had lifetime
risks of approximately 56 percent for developing cardiovascular disease ...
Lifetime risks for cardiovascular disease were strongly associated with risk
factor burden in middle age"
Acai counteracts oxidative stress, lengthens lifespan in fruit flies -
Science Daily, 8/21/12 - "a commercially available
acai berry product can lengthen the lives of fruit flies, when the flies'
lives are made short through additional oxidative stress. Under certain
conditions (a simple sugar diet) acai supplementation could triple flies'
lifespans, from eight to 24 days. Acai could also counteract the neurotoxic
effects of the herbicide paraquat on the flies ... Acai berries contain a
variety of antioxidant and anti-inflammatory compounds, such as
anthocyanins" - See
acai berry products at Amazon.com.
Regular jogging shows dramatic increase in life expectancy - Science
Daily, 5/3/12 - "Results show that in the follow-up
period involving a maximum of 35 years, 10,158 deaths were registered among
the non-joggers and 122 deaths among the joggers. Analysis showed that risk
of death was reduced by 44% for male joggers (age-adjusted hazard ratio
0.56) and 44% for female joggers (age-adjusted hazard ratio 0.56) ...
Furthermore the data showed jogging produced an age adjusted survival
benefit of 6.2 years in men and 5.6 years in women. Further analysis
exploring the amounts of exercise undertaken by joggers in the study has
revealed a U-shaped curve for the relationship between the time spent
exercising and mortality. The investigators found that between one hour and
two and a half hours a week, undertaken over two to three sessions,
delivered the optimum benefits, especially when performed at a slow or
average pace ... The ideal pace can be achieved by striving to feel a little
breathless. "You should aim to feel a little breathless, but not very
breathless," ... It improves oxygen uptake, increases insulin sensitivity,
improves lipid profiles (raising HDL and lowering triglycerides), lowers
blood pressure, reduces platelet aggregation, increases fibrinolytic
activity, improves cardiac function, bone density, immune function, reduces
inflammation markers, prevents obesity, and improves psychological function"
Study resolves controversy on life-extending red wine ingredient, restores
hope for anti-aging pill - Science Daily, 5/1/12 -
"The new findings show for the first time that the
metabolic benefits of the red wine ingredient known as resveratrol evaporate
in mice that lack the famed longevity gene SIRT1 ... They show that
resveratrol targets SIRT1 directly at moderate doses and hits other targets
at higher ones. Importantly, SIRT1 is required for resveratrol's benefits
irrespective of dose" - See
resveratrol products at Amazon.com.
Tiny amounts of alcohol dramatically extend a worm's life, but why? -
Science Daily, 1/20/12 - "How little ethanol is
that? ... The concentrations correspond to a tablespoon of ethanol in a
bathtub full of water or the alcohol in one beer diluted into a hundred
gallons of water ... The scientists found that when they raised the ethanol
level by a factor of 80, it did not increase the life span of the worms"
Simple lifestyle changes can add a decade or more healthy years to the
average lifespan, Canadian study shows - Science Daily, 10/22/11 -
"Achieving these seven simple lifestyle factors
gives people a 90 per cent chance of living to the age of 90 or 100, free of
not only heart disease and stroke but from a number of other chronic
illnesses including cancer ... 1. GET ACTIVE ... 2. KNOW AND CONTROL
CHOLESTEROL LEVELS ... 3. FOLLOW A HEALTHY DIET ... 4. KNOW AND CONTROL
BLOOD PRESSURE ... 5. ACHIEVE AND MAINTAIN A HEALTHY WEIGHT ... 6. MANAGE
DIABETES ... 7. BE TOBACCO FREE"
muscles weaken with age and points to possible therapy - Science Daily,
8/2/11 - "As we grow older, our skeletal muscles
tend to wither and weaken, a phenomenon known as sarcopenia. Sarcopenia,
which begins to appear at around age 40 and accelerates after 75, is a major
cause of disability in the elderly. Exercise can help counter the effects of
age-related muscle loss ... Both the aging process and the genetic defect
responsible for muscular dystrophy cause an increase in the production of
oxygen free radicals, highly reactive and harmful molecules. "Our data
suggest that this sets up a vicious cycle, in which the free radicals cause
ryanodine receptors to leak calcium into the cell. The calcium poisons
mitochondria -- organelles that power the cell -- leading to the release of
even more free radicals. This, in turn, causes more calcium leakage. With
less calcium available for contraction, the muscles get weaker," ... The
study also points to a possible therapy for sarcopenia: an experimental drug
called S107 ... "Most investigators in the field of aging have been saying
that the way to improve muscle strength is to build muscle mass, using such
therapies as testosterone, growth hormone, and insulin-like growth
factor-1," says Dr. Marks. "But an increase in muscle mass is not
necessarily accompanied by an increase in muscle function"
U.S. Death Rate Hits Record Low - WebMD, 3/16/11 -
"The 15 leading causes of death in 2009 and the
decreases in associated death rates were reported as follows: ... 1.Heart
disease: 3.7% ... 2.Cancer: 1.1% ... 3.Chronic lower respiratory diseases:
4.1% ... 4.Stroke: 4.2% ... 5.Accidents: 4.1% ..."
to long life? Not what you might expect - Science Daily, 3/12/11 -
""Don't work too hard, don't stress," doesn't work
as advice for good health and long life. Subjects who were the most involved
and committed to their jobs did the best. Continually productive men and
women lived much longer than their more laid-back comrades ... "One of the
findings that really astounds people, including us, is that the Longevity
Project participants who were the most cheerful and had the best sense of
humor as kids lived shorter lives, on average, than those who were less
cheerful and joking. It was the most prudent and persistent individuals who
stayed healthiest and lived the longest." ... Part of the explanation lies
in health behaviors -- the cheerful, happy-go-lucky kids tended to take more
risks with their health across the years, Friedman noted. While an
optimistic approach can be helpful in a crisis, "we found that as a general
life-orientation, too much of a sense that 'everything will be just fine'
can be dangerous because it can lead one to be careless about things that
are important to health and long life. Prudence and persistence, however,
led to a lot of important benefits for many years"
Can Exercise Keep You Young? - NYTimes.com, 3/2/11 -
"in heartening new research published last week in
The Proceedings of the National Academy of Sciences, exercise reduced or
eliminated almost every detrimental effect of aging in mice that had been
genetically programmed to grow old at an accelerated pace ... mitochondria
can accumulate small genetic mutations, which under normal circumstances are
corrected by specialized repair systems within the cell. Over time, as we
age, the number of mutations begins to outstrip the system’s ability to make
repairs, and mitochondria start malfunctioning and dying ... Half of the
mice were allowed to run on a wheel for 45 minutes three times a week,
beginning at 3 months ... At 8 months, when their sedentary lab mates were
bald, frail and dying, the running rats remained youthful. They had full
pelts of dark fur, no salt-and-pepper shadings. They also had maintained
almost all of their muscle mass and brain volume. Their gonads were normal,
as were their hearts. They could balance on narrow rods, the showoffs ...
But perhaps most remarkable, although they still harbored the mutation that
should have affected mitochondrial repair, they had more mitochondria over
all and far fewer with mutations than the sedentary mice had"
Happiness improves health and lengthens life - Science Daily, 3/1/11 -
"We reviewed eight different types of studies ...
the general conclusion from each type of study is that your subjective
well-being -- that is, feeling positive about your life, not stressed out,
not depressed -- contributes to both longevity and better health among
healthy populations ... Laboratory experiments on humans have found that
positive moods reduce stress-related hormones, increase immune function and
promote the speedy recovery of the heart after exertion. In other studies,
marital conflicts and high hostility in married couples were associated with
slow wound healing and a poorer immune response"
Fountain of youth from the tap? Environmental lithium uptake promotes
longevity, scientists demonstrate in worms - Science Daily, 2/18/11 -
"A regular uptake of the trace element lithium can
considerably promote longevity ... even a low concentration of lithium leads
to an increased life expectancy in humans as well as in a model organism,
the roundworm Caenorhabditis elegans ... the Jena scientists analyzed the
mortality rate in 18 adjacent Japanese municipalities in relation to the
amount of lithium contained in tap water from the respective regions. "We
found that the mortality rate was considerably lower in those municipalities
with more lithium in the drinking water," Ristow explains the key finding.
In a second experiment, the Jena scientists examined exactly this range of
concentration in the model organism C. elegans. The result was confirmed:
"The average longevity of the worms is higher after they have been treated
with lithium at this dosage," ... we know already that a higher uptake of
lithium through drinking water is associated with an improvement of
psychological well-being and with decreased suicide rates" - See
lithium products at iHerb.
Eat fiber, live longer - MSNBC, 2/14/11 - "Most
Americans aren't getting enough roughage in their diets. The average
American eats only about 15 grams of fiber each day, much less than the
current daily recommendation of 25 grams for women and 38 grams for men, or
14 grams per 1,000 calories. For example, a slice of whole wheat bread
contains 2 to 4 grams of fiber ... In the new study, the people who met the
guidelines were less likely to die during a nine-year follow-up period ...
The men and women who ate the highest amount of fiber were 22 percent less
likely to die from any cause compared to those who ate the lowest amount"
Between High-Density Lipoprotein Cholesterol and Survival to Age 85 Years in
Men (from the VA Normative Aging Study) - Am J Cardiol. 2011 Feb 4 - "We
categorized initial HDL cholesterol into <40 mg/dl (reference group), 40 to
49 mg/dl, or ≥50 mg/dl ... Treating HDL cholesterol as a continuous
predictor, we also determined the HR for each 10-mg/dl increment in HDL
cholesterol. Fully adjusted HR (95% confidence interval) for survival to 85
years of age for participants with an initial HDL cholesterol level ≥50
mg/dl compared to the reference was 0.72 (0.53 to 0.98). Each 10-mg/dl
increment in HDL cholesterol was associated with a 14% (HR 0.86, 0.78 to
0.96) decrease in risk of mortality before 85 years of age. In conclusion,
after adjusting for other factors associated with longevity, higher HDL
cholesterol levels were significantly associated with survival to 85 years
of age" - See
niacin at Amazon.com
(niacin increases HDL).
obesity to blame for lag in U.S. lifespan - MSNBC/Associated Press,
1/25/11 - "The U.S. spends more on health care than
any other nation yet has worse life expectancy than many — and a new report
blames smoking and obesity ... That may sound surprising, considering that
public smoking is being stamped out here while it's common in parts of
Europe. And obesity is a growing problem around the world ... But the U.S.
led those unhealthy trends, lighting up and fattening up a few decades ahead
of other high-income countries. And the long-term consequences are life
expectancy a few years shorter than parts of Europe and Japan"
alpha-carotene levels associated with longer life - Science Daily,
11/22/10 - "Oxygen-related damage to DNA, proteins
and fats may play a role in the development of chronic diseases like heart
disease and cancer ... Carotenoids -- including beta-carotene,
alpha-carotene and lycopene -- are produced by plants and microorganisms and
act as antioxidants, counteracting this damage ... Compared with individuals
with blood alpha-carotene levels between 0 and 1 micrograms per deciliter,
the risk of death during the study period was 23 percent lower among who had
concentrations between 2 and 3 micrograms per deciliter, 27 percent lower
with levels between 4 and 5 micrograms per deciliter, 34 percent lower with
levels between 6 and 8 micrograms per deciliter and 39 percent lower with
levels of 9 micrograms per deciliter or higher" - Note: There are
over 600 carotenoids and some claim that taking large amounts of just one of
them can cause a deficiency of the others. See
Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.com.
Regular exercise reduces large number of health risks including dementia and
some cancers, study finds - Science Daily, 11/15/10 -
"Regular exercise can reduce around two dozen
physical and mental health conditions and slow down how quickly the body
ages ... Health conditions covered by the review include: cancer, heart
disease, dementia, stroke, type 2 diabetes, depression, obesity and high
US Hispanics Have Longer Life Expectancy Than White and Black Americans
- ABC News, 10/14/10 - "long-term health has a lot
to do with diet, and immigrants are far less likely to indulge in the types
of fattening foods that have expanded the American waistline. Instead of
fast food and processed products, immigrants tend to favor fruit,
vegetables, rice and beans ... Experts add that Hispanic immigrants eat far
less red meat, instead consuming less-expensive chicken ... Besides a
healthy diet, Hispanic immigrants also have the strong social bonds with
family and friends that longevity experts say promote a long and happy life
-- including drinking and smoking less ... If you lose that family
connectedness, then you tend to have more health problems ... The people
across the board who live oldest and healthiest are people who are part of
social networks" - Should they have added exercise to that? I’ve
never seen any statistics but I think Hispanics might have on average more
physically demanding jobs. I saw a study several years ago where postal
workers that delivered mail door to door lived longer than postal workers in
an office. I run or swim and hour and a half a day but when I take on a
large project on my house I’m a lot sorer and start losing a pant size per
Amino acid supplement makes mice live longer - Science Daily, 10/5/10 -
"leucine, isoleucine, and valine extend the life
span of single-celled yeast ... Animals that were given the extra amino
acids over a period of months lived longer, with a median life span of 869
days compared to 774 days for untreated control animals, the researchers
report. That's an increase of 12 percent ... The findings in older mice
suggest that the supplementary mixture may be specifically beneficial for
those who are elderly or ill" - See
BCAA products at Amazon.com, it
contains the three of these.
Women's study finds longevity means getting just enough sleep - Science
Daily, 9/30/10 - "the secret to a long life may come
with just enough sleep. Less than five hours a night is probably not enough;
eight hours is probably too much ... sleeping 6.5 to 7.5 hours per night was
associated with best survival ... when sleep was measured objectively, the
best survival was observed among women who slept 5 to 6.5 hours ... Women
who slept less than five hours a night or more than 6.5 hours were less
likely to be alive at the 14-year follow-up"
Some interesting info on telomeres that someone sent:
Telomere Length Linked to Outcomes in Aplastic Anemia - nih.gov,
9/27/10 - "Aplastic anemia patients with shorter
chromosome tips, or telomeres, have a lower survival rate and are much
more likely to relapse after treatment than those with longer telomeres
... the blood cells of some patients with severe aplastic anemia disease
have extremely short telomeres ... nearly 60% of the patients responded
to immunosuppressive therapy. Of those who responded, the patients with
the shortest telomeres were most likely to have a later relapse. The
scientists found that the rate of relapse dropped as telomere lengths
increased ... The group of patients with the shortest telomeres was also
at greater risk for a conversion to bone marrow cancer (24%) than the
other 3 groups (3% to 13%). Survival rates differed as well. Only 66% of
patients with the shortest telomeres survived at least 6 years, compared
to an 84% survival rate for the other 3 groups combined"
Happy Healthy Long Life: There's No Way Around It: If You Want to Live
Longer You've Just Got to Do It! Get Out There & Exercise! - 2/6/08
- "by the time you're 65, well, there's just not
that much left. Which is exactly why not too many of us make it past 80,
90 or 100. Not to get you even more depressed about your rapidly
shrinking telomeres, but there have been a number of studies that have
shown how stress, especially in caregiver's of chronically ill children
and spouses of Alzheimer's patients have accelerated telomere shrinking.
One study even suggested that you can accelerate your biological age by
as much as 17 years if you're exposed to what you perceive as high
psychological stress! ... it looks as if it's a safe bet to start
lengthening your telomeres now, by EXERCISING!"
Coffee may protect against DNA damage: Study - Nutra USA, 9/7/10 -
"coffee is one of the richest sources of polyphenols in
the Western diet, with one cup of the stuff providing 350 milligrams of
phenolics. Of these, the most abundant compounds coffee are chlorogenic
acids, making up to 12 per cent of the green coffee bean. The most abundant
of these compounds is caffeic acid ... The subjects were assigned to drink
either 800 ml coffee or water daily for five days. Various measures of DNA
damage were used ... At the end of the study, a reduction in DNA damage, as
measured by a reduction in the formation of oxidised purines of 12.3 percent
was observed in the coffee drinkers" - [Abstract]
Impact of paper
filtered coffee on oxidative DNA-damage: Results of a clinical trial -
Mutat Res. 2010 Aug 13 - "consumed 800ml coffee or
water daily over 5 days ... The extent of DNA-migration attributable to
formation of oxidised purines (formamidopyrimidine glycosylase sensitive
sites) was decreased after coffee intake by 12.3%"
Resveratrol May Slow Aging in Humans - Medscape, 8/6/10 -
"the popular plant extract has been shown to prolong
life and reduce the rate of aging in roundworms, fruit flies, and yeast,
apparently because resveratrol affects a gene associated with longevity ...
resveratrol suppressed the generation of “free radicals” -- unstable
molecules known to cause oxidative stress and release pro-inflammatory
substances into the blood, resulting in damage to the blood vessel lining
... resveratrol also showed suppression of the inflammatory protein tumor
necrosis factor, or TNF, and other compounds that increase blood vessel
inflammation and interfere with insulin action, causing insulin resistance
and the risk of developing diabetes"
resveratrol products at Amazon.com.
and longevity tied to specific brain region in mice - Science Daily, 7/28/10
- "mice with increased brain SIRT1 have internal
mechanisms that make them use energy more efficiently, which helps them move
around in search of food even after a long fast. This increased
energy-efficiency could help delay aging and extend lifespan ... SIRT1 is at the
center of a network that connects metabolism and aging" - Related
articles on SIRT1:
Sirtuin1 may boost memory and learning ability; Discovery could lead to new
drugs to fight Alzheimer's, other neurological diseases - Science Daily,
7/11/10 - "Resveratrol, found in wine, has been
touted as a life-span enhancer because it activates a group of enzymes known
as sirtuins, which have gained fame in recent years for their ability to
slow the aging process. Now MIT researchers report that Sirtuin1 -- a
protein that in humans is encoded by the SIRT1 gene -- also promotes memory
and brain flexibility ... We have now found that SIRT1 activity also
promotes plasticity and memory"
Slowing Aging: Anti-aging Pathway Enhances Cell Stress Response
- Science Daily, 2/19/09 - "The researchers
discovered a new molecular relationship critical to keeping cells healthy
across a long span of time: a protein called SIRT1, important for caloric
restriction and lifespan and activated by resveratrol, regulates heat shock
factor 1 (HSF1), keeping it active. HSF1 in turn senses the presence of
damaged proteins in the cell and elevates the expression of molecular
chaperones to keep a cell's proteins in a folded, functional state.
Regulation of this pathway has a direct beneficial effect to cells ...
decrease in SIRT1 may help explain why protein misfolding diseases, such as
Alzheimer's, Parkinson's, Huntington's and adult-onset diabetes, are
diseases of aging"
- Drug 'tricks
body to lose weight' - BBC News, 11/5/08 -
"The drug SRT1720 - a chemical cousin of red
wine extract resveratrol - targets the protein SIRT1, which is thought to
combat ageing ... The French team from the University Louis Pasteur became
interested in the SIRT1 protein after earlier studies showing resveratrol
countered some effects of a high-calorie diet via SIRT1" - See
resveratrol at Amazon.com.
Wine Compound Spurs Diabetes Research - WebMD, 11/29/07 -
"In October, Chinese researchers reported
that resveratrol curbs insulin resistance in mice. Insulin is a hormone that
controls blood sugar. Insulin resistance can lead to type 2 diabetes ...
Like resveratrol, the lab-made chemicals activate a gene called SIRT1,
making the diabetic mice more sensitive to insulin ... the newly developed
chemicals are 1,000 times more potent than resveratrol"
Resveratrol regulates human adipocyte number and function in a
Sirt1-dependent manner - Am J Clin Nutr. 2010 May 12 -
"Taken together, our data suggest that resveratrol influences adipose tissue
mass and function in a way that may positively interfere with the
development of obesity-related comorbidities. Thus, our findings open up the
new perspective that resveratrol-induced intracellular pathways could be a
target for prevention or treatment of obesity-associated endocrine and
metabolic adverse effects"
Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via
SIRT1-Dependent AMPK Activation - J Agric Food Chem. 2009 Nov 20 -
"Similar to those effects associated with caloric restriction (CR),
resveratrol has multiple beneficial activities, such as increased life span
and delay in the onset of diseases associated with aging ... Here, we show
that resveratrol activated AMPK in both ER-positive and ER-negative breast
cancer cells ... Here, we show that resveratrol activated AMPK in both
ER-positive and ER-negative breast cancer cells. Once activated, AMPK
inhibited 4E-BP1 signaling and mRNA translation via mammalian target of
rapamycin (mTOR). Moreover, we also found that AMPK activity mediated by
resveratrol in cancer cells was due to inducing the expression of Sirtuin
type 1 (SIRT1) via elevation in the cellular NAD(+)/NADH in ER-positive
cells. To our knowledge, we demonstrate here for the first time that
resveratrol induces the expression of SIRT1 protein in human cancer cells.
These observations raise the possibility that SIRT1 functions as a novel
upstream regulator for AMPK signaling and may additionally modulate tumor
cell proliferation. Targeting SIRT1/AMPK signaling by resveratrol may have
potential therapeutic implications for cancer and age-related diseases"
Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via
Sirt1-FOXO1 signaling pathway - Biochem Biophys Res Commun. 2009 Mar
"Our results suggest that resveratrol may attenuate
fat deposition by inhibiting SREBP1 expression via Sirt1-FOXO1 pathway and
thus may have application for the treatment of NAFLD"
Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through
the SIRT1-FoxO1 pathway - Biochem Biophys Res Commun. 2008 Dec 3 -
"Loss of cardiomyocytes through apoptosis has been proposed as a cause of
ventricular remodeling and heart failure. Ischemia- and hypoxia-induced
apoptosis of cardiomyocytes reportedly plays an important role in many
cardiac pathologies. We investigated whether resveratrol (Res) has direct
cytoprotective effects against ischemia/hypoxia for cardiomyocytes. Exposure
of H9c2 embryonic rat heart-derived cells to hypoxia for 24h caused a
significant increase in apoptosis, as evaluated by TUNEL and flow cytometry,
while treatment with 20muM Res greatly decreased hypoxia-induced apoptosis
in these cells. Exposure of the cells to Res (20muM) caused rapid activation
of SIRT1, which had a dual effect on FoxO1 function: SIRT1 increased FoxO1's
ability to induce cell cycle arrest, but inhibited FoxO1's ability to induce
cell death. This effect could be reversed by SIRT1 inhibition. Results of
our study indicate that Res inhibits hypoxia-induced apoptosis via the
SIRT1-FoxO1 pathway in H9c2 cells. This polyphenol may have potential in
preventing cardiovascular disease, especially in coronary artery disease
restriction: what recent results suggest for the future of ageing research -
Eur J Clin Invest. 2010 May;40(5):440-50 - "the search
for substances that can reproduce the beneficial physiologic responses of CR
without a requisite calorie intake reduction, termed CR mimetics (CRMs), has
gained momentum. Material and methods Recent articles describing health and
lifespan results of CR in nonhuman primates and short-term human studies are
discussed. Additional consideration is given to the rapidly expanding search for
CRMs. Results The first results from a long-term, randomized, controlled CR
study in nonhuman primates showing statistically significant benefits on
longevity have now been reported. Additionally, positive results from
short-term, randomized, controlled CR studies in humans are suggestive of
potential health and longevity gains, while test of proposed CRMs (including
rapamycin, resveratrol, 2-deoxyglucose and metformin) have shown both positive
and mixed results in rodents"
Eat less, live longer? - New Scientist, 6/3/10 -
"One piece of evidence for this idea comes from studies in fruit flies and
rodents. If these animals are fed special diets with less amino acids - the
building blocks of proteins - they can eat as many calories as they want and
still live longer ... The protein theory is bad news for people on
low-carbohydrate weight-loss plans like the Atkins diet. "I'd be wary of diets
that put a heavy emphasis on protein," says Piper. "It's hard to see how that
could be healthy." Fontana goes one step further, saying that high-protein diets
could risk accelerated ageing and cancer ... There may be another reason for
vegans to celebrate. Studies on flies and rodents suggest that cutting intake of
one particular amino acid, called methionine, lengthens life to a similar degree
as calorie restriction. Proteins in meat and other animal products have high
levels of methionine, so a vegan diet would score well by that measure, too"
best age-erasing superfoods - MSNBC, 5/25/10 -
"Yogurt ... Various cultures claim yogurt as their own creation, but the
2,000-year-old food’s health benefits are not disputed: Fermentation spawns
hundreds of millions of probiotic organisms that serve as reinforcements to the
battalions of beneficial bacteria in your body, which keep your digestive tract
healthy and your immune system in top form, and provide protection against
cancer. Not all yogurts are probiotic, though, so make sure the label says “live
and active cultures.”"
Phosphorous in sodas and processed foods accelerates signs of aging, study
suggests - Science Daily, 4/26/10 - "high levels of
phosphates may add more "pop" to sodas and processed foods than once thought.
That's because researchers found that the high levels of phosphates accelerate
signs of aging. High phosphate levels may also increase the prevalence and
severity of age-related complications, such as chronic kidney disease and
cardiovascular calcification, and can also induce severe muscle and skin
Excessive alcohol consumption may lead to increased cancer risk - Science
Daily, 4/21/10 - "Researchers have detected a link
between alcohol consumption, cancer and aging that starts at the cellular level
with telomere shortening ... Telomeres are found at the region of DNA sequences
at the end of a chromosome, and are important for the genetic stability of
cells. As people age, telomere length shortens progressively ... Since telomere
shortening is thought to increase cancer risk, the researchers speculated that
those with shorter telomeres due to heavy alcohol consumption would have an
increased risk of cancer ... telomere length was dramatically shortened in those
who consumed heavy amounts of alcohol; telomere length was nearly half as long
as telomere length in the non-abusers (0.41 vs. 0.79 relative units)"
Anti-aging hormones: Little or no benefit and the risks are high, according to
experts - Science Daily, 4/13/10
Vitamin combo may delay ageing: Mouse study - Nutra USA, 3/1/10 -
"Results showed maintenance of youthful levels of
locomotor activity into old age in the supplemented animals, whereas old
non-supplemented mice showed a 50 per cent loss in daily movement, said the
researchers. This was accompanied by a loss of mitochondria activity, and
declines in brain signalling chemicals relevant to locomotion, such as striatal
neuropeptide Y. This chemical is associated with a range of functions, including
maintaining energy balance, as well as effects in memory and learning ... No
such declines were observed in supplemented animals ... The supplement was
composed of vitamins B1, B3 (niacin), B6, B12, C, D, E, folic acid,
beta-carotene, CoQ10, rutin, bioflavonoids, ginko biloba, ginseng, green tea
extract, ginger root extract, garlic, L-Glutathione, magnesium, selenium,
potassium, manganese, chromium picolinate, acetyl L-carnitine, melatonin,
alpha-lipoic acid, N-acetyl cysteine, acetylsalicylic acid, cod liver oil, and
flax seed oil"
formula that maintains youthful function into old age - Science Daily,
2/12/10 - "Using bagel bits soaked in the supplement to
ensure consistent and accurate dosing, the formula maintained youthful levels of
locomotor activity into old age whereas old mice that were not given the
supplement showed a 50 per cent loss in daily movement, a similar dramatic loss
in the activity of the cellular furnaces that make our energy, and declines in
brain signaling chemicals relevant to locomotion. This builds on the team's
findings that the supplement extends longevity, prevents cognitive declines, and
protects mice from radiation ... Ingredients consists of items that were
purchased in local stores selling vitamin and health supplements for people,
including vitamins B1, C, D, E, acetylsalicylic acid, beta carotene, folic acid,
garlic, ginger root, ginkgo biloba, ginseng, green tea extract, magnesium,
melatonin, potassium, cod liver oil, and flax seed oil" - Sounds like
most of what I'm already taking. - Ben
Overweight Older People Live Longer - WebMD, 1/28/10 -
"people who met the criteria for being overweight were
17% less likely to die compared to people of normal weight ... In the newly
reported research, overweight study participants in their 70s followed for up to
10 years had a 13% lower risk of death than participants classified as normal
weight ... Obese and normal-weight study participants had a similar risk of
death over the 10 years of follow-up. Underweight study participants had the
highest risk of death, even after the researchers adjusted for the wasting
effects of disease"
ways to live longer - MSNBC, 1/5/10 - "Eat omega-3s
every day ... Sniff lavender or rosemary ... Don’t be a drama queen ... Stop
eating before you’re stuffed ... Stay the weight you were at 18 ... Diversify
your workout ... Munch on veggies or fruits every 4 hours ... Floss daily ...
Have a standing lunch date ... Donate blood"
restriction: Scientists take important step toward 'fountain of youth' -
Science Daily, 12/26/09 - "They found that the normal
cells lived longer, and many of the precancerous cells died, when given less
glucose. Gene activity was also measured under these same conditions. The
reduced glucose caused normal cells to have a higher activity of the gene that
dictates the level of telomerase, an enzyme that extends their lifespan and
lower activity of a gene (p16) that slows their growth. Epigenetic effects
(effects not due to gene mutations) were found to be a major cause in changing
the activity of these genes as they reacted to decreased glucose levels"
- See my Insulin and Aging page. Insulin
controls glucose levels. Insulin resistance causes high glucose.
Look Young to Live Longer? - WebMD, 12/15/09 -
"Perceived age, the researchers say, adjusted for chronological age and sex,
also correlated with physical and cognitive functioning, as well as length of
leukocyte telomeres - chromosome tips on DNA of people's white blood cells ...
Shorter telomere length is associated with a “host of diseases related to aging
and lifestyle factors and has been shown to be associated with mortality,”"
Scientists find molecular trigger that helps prevent aging and disease -
Science Daily, 11/18/09 - "diabetes reduces activation
of CBP, leading Dr. Mobbs to conclude that a high-calorie diet that leads to
diabetes would have the opposite effect of dietary restriction and would
Overweight And Live Longer, German Study Suggests - Science Daily, 10/16/09
- "overweight does not increase death rates, although
obesity does increase them by 20%. As people grow older, obesity makes less and
less difference ... For coronary heart disease, overweight increases risk by
about 20% and obesity increases it by about 50%. On the other hand, a larger BMI
is associated with a lower risk of bone and hip fracture"
'Anti-Atkins' Low Protein Diet Extends Lifespan In Flies - Science Daily,
10/1/09 - Science Daily, 10/1/09 - "Flies fed an
"anti-Atkins" low protein diet live longer because their mitochondria function
Drug Has Potential to Slow Aging - WebMD, 7/10/09 -
"At first, the drug was not readily absorbed into the bloodstream of the mice,
so a specialized feed was developed with an encapsulated, timed-release form of
Important In Aging Identified - Science Daily, 7/10/09
Antibiotic Delayed Aging in Mice - NYTimes.com, 7/8/09 -
"The effectiveness of rapamycin in extending the life of
elderly mice was discovered by accident. The researchers found that the mice fed
rapamycin were not getting the proper dose in their bloodstream. They
reformulated the drug in the form of capsules that fed slow doses to the
intestine, but by that time the mice were elderly. Nonetheless, life span
increased by 14 percent in the females and 9 percent in the males"
Diet Thwarts Aging, Disease In Monkeys - Science Daily, 7/9/09 -
"We observed that caloric restriction reduced the risk
of developing an age-related disease by a factor of three and increased survival
... The incidence of cancerous tumors and cardiovascular disease in animals on a
restricted diet was less than half that seen in animals permitted to eat freely.
Remarkably, while diabetes or impaired glucose regulation is common in monkeys
that can eat all they want, it has yet to be observed in any animal on a
Island Compound Extends Lifespan Of Old Mice: 28 To 38 Percent Longer Life -
Science Daily, 7/8/09
Biological 'Fountain Of Youth' Found In New World Bat Caves - Science Daily,
Study: Overweight People Live Longer - WebMD, 6/25/09 -
"There is more evidence that people who are overweight
tend to live longer than people who are underweight, normal weight, or obese ...
Those classified as underweight were 73% more likely to die ... Those classified
as extremely obese with BMI of 35 or greater were 36% more likely to die ...
Those classified as obese with BMI 30-34.9 had about the same risk of death ...
Those classified as overweight with BMI 25-29.9 were 17% less likely to die"
Confirm The Causes Of Iron Deficiency Anemia In Young Women - Science Daily,
Melatonin: The Fountain Of Youth? - Science Daily, 6/22/09 -
"Melatonin can slow down the effects of aging. A team at
laboratoire Arago in Banyuls sur Mer (CNRS / Université Pierre et Marie Curie)
has found that a treatment based on melatonin can delay the first signs of aging
in a small mammal ... studied the long-term effects of melatonin on the Greater
White-toothed shrew, a small nocturnal insectivorous mammal. Under normal
conditions, this animal shows the first signs of aging after reaching 12 months,
mainly through the loss of circadian rhythm in its activities. By continuously
administering melatonin, starting a little before 12 months, the appearance of
these first signs was delayed by at least 3 months, which is a considerable
period in relation to the lifespan of this shrew ... Melatonin is now known to
play several beneficial roles. These include being an antioxidant, an
anti-depressant, and helping to remediate sleep problems" - See
melatonin at Amazon.com.
Multivitamins linked to younger ‘biological age’: Study - Nutra USA, 5/27/09
- "Compared to non-multivitamin users, the researchers
noted that that telomeres were on average 5.1 per cent longer for daily
multivitamin users ... Whereas the evidence is not sufficient to conclude that
these 2 dietary antioxidants mediated the observed relation, the results are
consistent with experimental findings that vitamins C and E protect telomeres in
vitro" - [Abstract]
Multivitamin use and telomere length in women - Am J Clin Nutr. 2009
Jun;89(6):1857-63 - "After age and other potential
confounders were adjusted for, multivitamin use was associated with longer
telomeres. Compared with nonusers, the relative telomere length of leukocyte DNA
was on average 5.1% longer among daily multivitamin users (P for trend = 0.002).
In the analysis of micronutrients, higher intakes of vitamins C and E from foods
were each associated with longer telomeres, even after adjustment for
multivitamin use. Furthermore, intakes of both nutrients were associated with
telomere length among women who did not take multivitamins"
Glass Of Wine A Day May Boost Life Expectancy By Five Years - Science Daily,
4/29/09 - "light long term alcohol consumption of all
types—up to 20 g a day— extended life by around two extra years compared with no
alcohol at all. Extended life expectancy was slightly less for those who drank
more than 20 g ... men who drank only wine, and less than half a glass of it a
day, lived around 2.5 years longer than those who drank beer and spirits, and
almost five years longer than those who drank no alcohol at all"
Linked To Reduced Risk Of Death - Science Daily, 3/13/09 -
"a lower IQ was strongly associated with a higher risk
of death from causes such as accidents, coronary heart disease and suicide ...
the link between IQ and mortality could be partially attributed to the healthier
behaviours displayed by those who score higher on IQ tests ... People with
higher IQ test scores tend to be less likely to smoke or drink alcohol heavily,
they eat better diets, and they are more physically active"
Sweet: Over-consumption Of Sugar Linked To Aging - Science Daily, 3/9/09 -
"We know that lifespan can be extended in animals by
restricting calories such as sugar intake ...it's not sugar itself that is
important in this process but the ability of cells to sense its presence ... the
lifespan of yeast cells increased when glucose was decreased from their diet.
They then asked whether the increase in lifespan was due to cells decreasing
their ability to produce energy or to the decrease in signal to the cells by the
glucose sensor ... cells unable to consume glucose as energy source are still
sensitive to the pro-aging effects of glucose. Conversely, obliterating the
sensor that measures the levels of glucose significantly increased lifespan"
Aging: Anti-aging Pathway Enhances Cell Stress Response - Science Daily,
2/19/09 - "The researchers discovered a new molecular
relationship critical to keeping cells healthy across a long span of time: a
protein called SIRT1, important for caloric restriction and lifespan and
activated by resveratrol, regulates heat shock factor 1 (HSF1), keeping it
active. HSF1 in turn senses the presence of damaged proteins in the cell and
elevates the expression of molecular chaperones to keep a cell's proteins in a
folded, functional state. Regulation of this pathway has a direct beneficial
effect to cells ... decrease in SIRT1 may help explain why protein misfolding
diseases, such as Alzheimer's, Parkinson's, Huntington's and adult-onset
diabetes, are diseases of aging" - See
resveratrol products at Amazon.com.
Less May Not Extend Human Life: Caloric Restriction May Benefit Only Obese Mice
- Science Daily, 1/26/09 - "For lean mice – and possibly
for lean humans, the authors of a new study predict – the anti-aging strategy
known as caloric restriction may be a pointless, frustrating and even dangerous
exercise ... Today there are a lot of very healthy people who look like
skeletons because they bought into this ... Contrary to what is widely believed,
caloric restriction does not extend (the) life span of all strains of mice ...
caloric restriction begun in older mice – both in DBA and leaner C57 individuals
– actually shortened life span"
Gastrointestinal Drug Slows Aging, Researchers Say - Science Daily, 1/6/08 -
"Recent animal studies have shown that clioquinol – an
80-year old drug once used to treat diarrhea and other gastrointestinal
disorders – can reverse the progression of Alzheimer's, Parkinson's and
Huntington's diseases ... clioquinol acts directly on a protein called CLK-1,
often informally called "clock-1," and might slow down the aging process ...
Because clock-1 affects longevity in invertebrates and mice, and because we're
talking about three age-dependent neurodegenerative diseases, we hypothesize
that clioquinol affects them by slowing down the rate of aging ... clioquinol
was withdrawn from the market after being blamed for a devastating outbreak of
subacute myelo-optic neuropathy (SMON) in Japan in the 1960s. However, because
no rigorous scientific study was conducted at the time, and because clioquinol
was used safely by millions before and after the Japanese outbreak, some
researchers think its connection to SMON has yet to be proven" - I
Googled clioquinol and I don't think it's available anywhere.
Major Theories About Human Cellular Aging Supported By New Research -
Science Daily, 12/30/08 - "old age is the final stage of
a developmental program AND the result of a lifelong accumulation of unrepaired
cellular and molecular damage ... When fatty acids build up, yeast cells explode
from within, scattering their contents and spreading inflammation to neighboring
cells ... In addition to cell death, the accumulation of fatty acids sets off
chemical reactions that ultimately produce a lipid called diacylglycerol, which
impairs many of the yeast's stress response-related defenses ... Low-calorie
diets, which have been shown to increase lifespan and delay age-related
disorders in nonhuman primates and other organisms, altered the way fats were
processed in the yeast cells"
a Possible Cause of Aging - NYTimes.com, 11/26/08 -
"A new insight into the reason for aging has been gained by scientists trying to
understand how resveratrol, a minor ingredient of red wine, improves the health
and lifespan of laboratory mice. They believe that the integrity of chromosomes
is compromised as people age, and that resveratrol works by activating a protein
known as sirtuin that restores the chromosomes to health ... Dr. Sinclair has
been taking large daily doses of resveratrol since he and others discovered five
years ago that it activated sirtuin. “I’m still taking it and I feel great,” he
said, “but it’s too early to say if I’m young for my age."" - See
resveratrol products at Amazon.com.
Healthy Lifestyle Halves The Risk Of Premature Death In Women - Science
Daily, 9/16/08 - "Over half of deaths in women from
chronic diseases such as cancer and heart disease could be avoided if they never
smoke, keep their weight in check, take exercise and eat a healthy diet low in
red meat and trans-fats"
Clean living 'slows cell ageing' - BBC News, 9/15/08 -
"Among 24 men asked to adopt healthy lifestyle changes for a US study in The
Lancet Oncology, levels of telomerase increased by 29% on average ... Telomerase
repairs and lengthens telomeres, which cap and protect the ends of chromosomes
housing DNA ... These consisted of a diet high in fruit and vegetables,
supplements of vitamins and fish oils, an exercise regimen and classes in stress
management, relaxation techniques and breathing exercises"
Vitamin D Levels Pose Large Threat To Health; Overall 26 Percent Increased Risk
Of Death - Science Daily, 8/12/08 - "This translates
overall to an estimated 26 percent increased risk of any death, though the
number of deaths from heart disease alone was not large enough to meet
scientific criteria to resolve that it was due to low vitamin D levels ...
Previous results from the same nationwide survey showed that 41 percent of men
and 53 percent of women are technically deficient in the nutrient, with vitamin
D levels below 28 nanograms per milliliter" - See
vitamin D at Amazon.com.
Running Slows the Effects of Aging - WebMD, 8/11/08 -
"Older runners have fewer disabilities,
remain more active as they get into their 70s and 80s, and are half as likely as
non-runners to die early deaths, the study shows
... If you had to pick one thing to make people healthier as they age, it would
exercise ... The researchers used
national death records to learn which participants died and why. Nineteen years
into the study, 34% of the non-runners had died, compared with only 15% of the
runners" - [Science
Low Level of Vitamin D Ups Death Risk - WebMD, 8/11/08 -
"Over an average follow-up period of about nine years,
1,806 participants died. The researchers found a 26% increased risk of death
from any cause for the quartile of participants with the lowest vitamin D levels
compared to those with the highest levels" - See
vitamin D at Amazon.com.
Resveratrol, Found In Red Wine, Wards Off Effects Of Age On Heart, Bones, Eyes
And Muscle - Science Daily, 7/3/08 - "This study,
conducted and supported in part by the National Institute on Aging (NIA), part
of the National Institutes of Health, is a follow-up to 2006 findings that
resveratrol improves health and longevity of overweight, aged mice. The report
confirms previous results suggesting the compound, found naturally in foods like
grapes and nuts, may mimic, in mice, some of the effects of dietary or calorie
restriction, the most effective and reproducible way found to date to alleviate
age-associated disease in mammals" - See
resveratrol products at Amazon.com.
Substance In Red Wine, Resveratrol, Found To Keep Hearts Young - Science
Daily, 6/4/08 - "Resveratrol is active in much lower
doses than previously thought and mimics a significant fraction of the profile
of caloric restriction at the gene expression level ... In animals on a
restricted diet, 90 percent of those heart genes experienced altered gene
expression profiles, while low doses of resveratrol thwarted age-related change
in 92 percent. The new findings, say the study's authors, were associated with
prevention of the decline in heart function associated with aging" - See
resveratrol products at Amazon.com.
Low-dose resveratrol may slow ageing: for mice at least - Nutra USA, 6/4/08
- "animals in the calorie-restriction and low-dose
resveratrol groups had altered gene expression profiles in 90 and 92 per cent,
respectively, in the heart ... In short, a glass of wine or food or supplements
that contain even small doses of resveratrol are likely to represent "a robust
intervention in the retardation of cardiac ageing,"" - See
resveratrol products at Amazon.com.
Red wine may
protect heart from aging’s toll - MSNBC - 6/3/08 -
"Resveratrol at low doses can retard some aspects of the aging process,
including heart aging, and it may do so by mimicking some of the effects of
caloric restriction, which is known to retard aging in several tissues and
extend life span" - See
resveratrol products at Amazon.com.
lipoic acid supplementation can mimic or block the effect of dietary restriction
on life span -Mech Ageing Dev. 2008 Apr 22;129(6):341-348 -
"Ad libitum feeding a diet supplemented with lipoic acid
can therefore act as mimetic of DR to extend survival" - See
alpha lipoic acid at Amazon.com.
Lifelong prebiotic supplements may enhance survival: rat study - Nutra USA,
4/24/08 - "In terms of survival, at 18 months of age,
all the animals in the prebiotic group were still alive, compared to 76 per cent
in the control group. After 24 months, 81 per cent of the rats in the prebiotic
group were alive, compared to only 52 per cent of controls" - [Abstract]
inulin products at iHerb.
Effects of lifelong intervention with an oligofructose-enriched inulin in rats
on general health and lifespan - Br J Nutr. 2008 Apr 11;:1-8 -
"a diet with 10 % of an oligofructose-enriched inulin
(Synergy1) ... During the whole intervention period, male rats receiving
Synergy1 (SYN1-M) displayed lower body weight, cholesterol and plasma
triacylglycerolaemia compared with the controls (Cont-M). The survival rate at
24 months of age of SYN1-M rats was 35.3 % greater than that of Cont-M rats. In
female rats, the Synergy1 supplementation (SYN1-F) group also reduced body
weight, cholesterol and triacylglycerolaemia levels, but results were less
consistent over the experiment. The survival rate at 24 months of age in SYN1-F
rats was 33.3 % greater compared with that of the control (Cont-F) group. To
conclude, lifelong intervention with Synergy1 improved biological markers during
ageing and survival rate (lifespan) of rats" - See
inulin products at iHerb.
Dehydroepiandrosterone Sulfate Levels Predict Longevity in Men: 27-Year
Follow-Up Study in a Community-Based Cohort (Tanushimaru Study) - J Am
Geriatr Soc. 2008 Apr 18 - "in men after adjustments for
age, systolic blood pressure, and fasting plasma glucose showed significantly
(log-rank stat =10.6; P<.001) greater longevity in the highest group (200
mug/dL) than in the moderate (130-199 mug/dL) or lowest groups (129 mug/dL)"
DHEA at Amazon.com.
Lipoic acid significantly restores, in rats, the age-related decline in
- Br J Pharmacol. 2008 Feb 25 - "In old animals,
endothelium-dependent relaxation in aortic rings was decreased, GSH levels and
its redox state in aortic endothelia were over 30% lower and nSMase activity and
endothelial ceramide levels were three-fold increased, relative to young (2-4
mo) rats. LA treatment of old animals improved relaxation in aortic rings,
reversed the changes in endothelial GSH, in nSMase activities and in ceramide
levels. Similar effects on GSH levels and nSMase activity in old rats were also
induced by treatment with GSH monoethylester. Activation (by phosphorylation) of
eNOS was decreased by about 50% in old rats and this age-related decrease was
partially reversed by LA treatment" - See
alpha lipoic acid at Amazon.com.
Sedentary Lifestyles Associated With Accelerated Aging Process - Science
Daily, 1/28/08 - "Telomere
length decreased with age, with an average loss of 21 nucleotides
(structural units) per year. Men and women who were less
physically active in their leisure time had shorter leukocyte telomeres than
those who were more active. ... "The mean difference in leukocyte telomere
length between the most active [who performed an average of 199 minutes of
physical activity per week] and least active [16 minutes of physical activity
per week] subjects was 200 nucleotides, which means that the most active
subjects had telomeres the same length as sedentary individuals up to 10 years
younger, on average."" - I'm must be in fat city on this one. I must
have averaged 60 minutes per day since I've been 18 which comes to 420 minutes
per week. Maybe that's the main reason people claim I look young. Plus I've
always taken vitamin D which helps with telomere length also. - Ben
Sustained Tubulo-interstitial Protection in SHRs by Transient Losartan
Treatment: An Effect of Decelerated Aging? - Am J Hypertens. 2008 Jan 10 -
"Transient losartan treatment reduces cell-turnover not
only acutely but also for a prolonged period after drug withdrawal. This results
in the long-term in reduced aging and attenuated tubulo-interstitial damage,
suggesting there exists a modulating effect of angiotensin II (ANGII)-antagonism
on long-term cell turnover" - Note: Losartan is an
ARB. I would think that telmisartan
(also and ARB and my recommendation for hypertension) would give the same
Health Behaviors Can Add 14 Extra Years Of Life - Science Daily, 1/8/08 -
"People who adopt four healthy behaviours -- not
smoking; taking exercise; moderate alcohol intake; and eating five servings of
fruit and vegetables a day -- live on average an additional fourteen years of
life compared with people who adopt none of these behaviours"
Extract Found To Increase Lifespan - Science Daily, 12/5/07 -
"Flies that ate a diet rich with Rhodiola rosea, an
herbal supplement long used for its purported stress-relief effects, lived on an
average of 10 percent longer than fly groups that didn’t eat the herb ...
Although this study does not present clinical evidence that Rhodiola can extend
human life, the finding that it does extend the lifespan of a model organism,
combined with its known health benefits in humans, make this herb a promising
candidate for further anti-aging research ... Rhodiola rosea ... has been used
by Scandinavians and Russians for centuries for its anti-stress qualities ...
patients taking a Rhodiola extract called SHR-5 reported fewer symptoms of
depression than did those who took a placebo" - See
Rhodiola rosea at Amazon.com.
Fit Beats Fat for a Longer Life - WebMD, 12/4/07 -
"Fitness was found to be a strong predictor of longevity in the study, which
involved adults ages 60 and older, while obesity had little influence on death
Hydrogen Sulfide Hold The Key To A Long Life? - Science Daily, 12/4/07
Hormone May Contribute To Longevity - Science Daily, 11/21/07 -
"long-lived Snell dwarf mice burn less glucose and more
fatty acids during periods of fasting, and as a result produce fewer free
radicals ... The key to this switch may be
adiponectin, a hormone produced by fat cells that helps lower glucose
production and stimulates cells to use fat for energy instead. The researchers
found that Snell mice had three times as much adiponectin in their blood as
control mice" - See my adiponectin page
for ways to increase it. Something that was also in today's abstracts was
increased adiponectin 156%.
Commonly Used To Treat Bipolar Disorder Dramatically Increases Lifespan In Worms
- Science Daily, 10/30/07 - "Nematode worms treated with
lithium show a 46 percent increase in lifespan, raising the tantalizing question
of whether humans taking the mood affecting drug are also taking an anti-aging
medication" - See lithium products at
Can Fat Be Fit? -- Scientific American, 9/07
Sweets May Spell A Longer Life, Study In Worms Suggests - Science Daily,
10/2/07 - "A new study in Cell Metabolism reveals that
worms live to an older age when they are unable to process the simple sugar
Loneliness Can Speed Aging - WebMD, 8/20/07 -
"lonely people live in a heightened sense of arousal, which could have long-term
effects on heart disease and other health problems"
Extends Life In Yeast, Scientists Find - Science Daily, 5/3/07 -
"providing a newly discovered vitamin activates the
yeast anti-aging gene product Sir2, which resembles sirtuins found in humans.
The new work builds on Brenner's prior discovery of the vitamin, termed NR
(nicotinamide riboside), a natural product found in milk. Like the B3 vitamin,
niacin, NR is a precursor to a versatile cellular factor that is vital for all
New Clues on What Causes Aging - WebMD, 12/21/06
Cool Mice Live Longer - WebMD, 11/2/06 -
"the cool mice live significantly longer than normal
mice. Females lived about 20% longer than normal. Males lived about 12%
Mutations That Lead To Apoptosis May Contribute To Aging In Mammals -
Science Daily, 7/15/05 - "mutations in the
mitochondria caused by obesity and lack of exercise -- not oxidative stress
from free radicals -- may be a key factor in the aging process"
Obesity, Smoking Linked to Faster Aging - WebMD, 6/13/05 -
"Telomeres are the tips of the chromosomes, which
contain DNA. They gradually shorten over a lifetime ... The difference in
telomere length between being lean and being obese corresponds to 8.8 years
of aging ... Obesity and smoking are important risk factors for many
age-related diseases. Both are states of heightened oxidative stress … and
Anti-aging Enzyme's Secrets Revealed - Science Daily, 4/1/05
Mountain Life Spells Longer Life - Science Daily, 3/29/05 -
"as blood lipids and blood pressure were higher
among the mountain residents, other 'protective' factors must be at play ...
living at moderately high altitude produces long term physiological changes
in the body to enable it to cope with lower levels of oxygen, and that this,
combined with the exertion required to walk uphill regularly on rugged
terrain, could give the heart a better work-out"
- Live long, the
Okinawan way - Maui News, 1/14/05
System That Regulates Blood Pressure May Also Affect Aging - Science
Social & Environmental Factors Play Important Role In How People Age, Two
Studies Find - Science Daily, 9/14/04 -
"those who scored high on positive affect were
significantly less likely to become frail. Each unit increase in baseline
positive affect score was associated with a three percent decreased risk of
- Healthy Aging
Requires Healthy Attitudes - WebMD, 9/13/04 -
"the patients who exhibited more positive emotions
were significantly less likely to become frail. For example, every point
increase in a senior's positive effect score at the start of the study was
associated with a 3% decreased risk of frailty"
Why do the Japanese live so long? - Guardian Unlimited, 6/10/04 -
"People in Japan eat a third fewer calories than the
typical North American. What they eat is also important: more seafood and,
hence, healthy fish oils ... the Japanese are less sedentary than
westerners, and Japan a less stressed society"
Insulin Plays Central Role In Aging, Brown Scientists Discover - Science
Daily, 6/4/04 -
"insulin regulates its own production and that it
directly regulates tissue aging. The principle: Keep insulin levels low and
cells are stronger, staving off infection and age-related diseases such as
cancer, dementia and stroke"
Insulin plays central role in ageing, explains benefits of calorie reduction
- Nutra USA, 6/3/04 -
"if insulin levels remain low, cells are stronger
and can ward off infection and age-related diseases such as cancer, dementia
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain
and fat body - Nature. 2004 Jun 3;429(6991):562-6
DNA damage could be a start to aging, study suggests - USA Today,
"the results are also consistent with the theory
that so-called "free radicals" play a role in aging"
Connections Build Healthier Lives - WebMD, 4/30/04 -
"the prevalence of ill health was highest among
those who rarely or never attended church and lowest among those that
attended church regularly. Members of civic groups or those who volunteered
regularly were also more likely to be completely healthy and less likely to
report complete ill health than others"
- How to Age Well
- WebMD, 10/27/03 -
"What made them different than the other half? One
thing stands out. Those who stayed healthy had perfectly healthy hearts.
They didn't even have "subclinical" heart problems, the ones so minor they
can only be detected by testing ... For men, having subclinical heart
disease was like being 6.5 years older. For women, it was like being 5.5
years older ... refrain from smoking, lower their blood lipids, watch blood
pressure, and avoid obesity through diet and exercise"
- Longevity May
Run in Your Blood - WebMD, 10/14/03 -
"the HDL and LDL particle sizes were significantly
larger in the exceptionally old adults compared with both control groups,
regardless of their cholesterol levels ... this trait was also associated
with lower rates of high blood pressure, heart disease, and other health
problems that account for a large number of deaths among the elderly"
- Does Growing
Old Cause Cancer? - WebMD, 9/25/03
The Serious Search for an Anti-Aging Pill - Scientific America, 8/03 -
"Regrettably, however, 2DG has a fatal flaw
preventing it from being the "magic pill" we were hoping for. Though safe at
certain low levels, it apparently becomes toxic for some animals when the
amount delivered is raised just a bit or given over long periods ...
Treatment with antidiabetic medications that enhance cellular sensitivity to
insulin might be helpful as well, as long as the amounts given do not cause
blood glucose levels to fall too low ... Drugs that replicate only selected
effects of caloric restriction could have a role to play as well. In theory,
antioxidant vitamins might fit that bill"
Children of Centenarians Have Delays in Age-Related Diseases - Doctor's
Guide, 5/20/03 -
"Fewer offspring of centenarians took prescription
medicines, and they have lower weight and body mass compared to controls"
- Reaching 100 Is
Largely a Matter of Genes - WebMD, 4/8/03
Survival to 90 Years Linked to Low Weight in Young Adulthood and Exercise
- Doctor's Guide, 4/8/03 -
"baseline height and weight were not associated with
mortality. However, a higher weight at age 21
was associated with increased odds of dying before reaching 90 years
(OR=1.04 per 5 lb increase, P 0.0001). Those who exercised were 24-31% less
likely to die by the age of 90 (OR=0.76, P 0.0001 for less than 1 hour per
day, OR=0.69, P 0.0001 for 1 hour or more per day). Similarly, being in the
mid tertile of BMI at baseline (22-24 for men, 20-23 for women) was
associated with decreased odds of dying before age 90 (OR=0.70, P 0.0001)"
- The Fight for
the Fountain of Youth - WebMD, 2/10/03
A Prescription for Longevity - Physician's Weekly, 1/27/03 -
"Okinawans have no genetic predisposition to
longevity but rather benefit from the consumption of vegetables, tofu,
seaweed; the pursuit of rigorous activity; and a low stress lifestyle. The
authors claim if Americans could adopt the habits of Okinawans, "80 percent
of the nation¹s coronary care units, one-third of the cancer wards, and a
lot of nursing homes would be shut down.""
- Less Body Fat =
Longer Life - WebMD, 1/23/03 -
"Of the 250 mice in Bluher's study, half were
specially bred to lack a response to the hormone insulin specifically in
their fat cells -- he calls them "FIRKO mice." These mice were unable to
store body fat. The normal mice were able to gain weight and body fat as
usual ... The normal mice lived normal mouse-length lives -- 30 months. But
at 30 months, 80% of the FIRKO mice were still alive ... His study suggests
that increased metabolism is the secret to the FIRKO mouse's leanness and
Longevity Runs In Families: Study Looks At Genetics, Environment -
Intelihealth, 11/25/02 -
"Female children of the centenarians weighed, on
average, 146 pounds, while the female children of the control group weighed
158, on average. The male children of the centenarians weighed 184, on
average, while the male children in the control group had an average weight
- Present From Mom
and Dad: A Longer Life - WebMD, 11/18/02
Generous spirit may yield generous life span - USA Today, 11/14/02
- Scientists Extend
Life Span - WebMD, 10/25/02
- Supportive Family
Helps Successful Aging - WebMD, 5/24/02
- Mountain Life May
Make Women Age Faster - WebMD, 4/24/02 -
"New research shows that life at high altitudes can
speed the aging process for a woman by affecting her hormones ... In fact,
by age 70, the levels of DHEA in the women who
lived in the mountains were only about 40% of those in the comparison group"
Gene Scientists Find Clues To Why We Age - Intelihealth, 4/12/02
Boomers Search For Relief From Aging - Intelihealth, 4/10/02 -
"But I feel like I'm launching into one of the most
exciting periods of my life. And I want my quality of life to be good, so
that I can continue to do all the things I enjoy" - That's the whole
point about the information on my web site.
- Warning Against
'Anti-Aging' Medicine - WebMD, 3/6/02 - Articles like this burn me up.
Most people will be six feet under before those studies come in. I feel you
need to go with the best scientific information available at the time. Also,
Dr. Smith’s comment that "There is as yet no convincing evidence that
administration of any specific compound, natural or artificial, can globally
slow aging in people, or even in mice or rats" is absolutely false. Take for
example the study published in the 2/19/02 Proceedings of the National
Academy of Sciences on alpha lipoic acid and acetyl-l-carnitine or the
studies with deprenyl and rats? I could go on and on. Some doctors think
that the three credits in nutrition they got back in 1985 from text books
written in the 70’s allow them to make bold lies without even reading the
research. LEF has references for their articles. I guess if your a doctor,
you can make bold statements like Dr. Smith's without references. I agree
with the following statement by Dr. Klatz: "To become a physician, you have
to take the Hippocratic Oath, in which you swear to "do no harm." But there
are many ways to interpret that phrase. As all Catholics are aware, there
are sins of omission and sins of commission. Cutting off the wrong leg of a
diabetic or operating on the wrong side of the head in a patient with a
brain tumor as happened recently in two New York hospitals is clearly doing
harm. But what about not keeping abreast of the latest diagnostic treatment
or advances? Or failing to inform a patient of lifestyle changes or options
that could drastically lower risk of disease? Or taking a authoritarian,
I-know-better-than-you attitude that effectively cuts off all questions
about alternative measures and treatments? All these "sins of omission" may
end up doing you harm in terms of accelerated aging, disease, and death." -
Cancer-Fighting Protein May Play Role In Aging, Mouse Study Suggests -
Optimism May Lower Heart Disease Risk In Older Men - Intelihealth,
"The researchers found that the most highly
optimistic men were less likely to develop heart disease than the most
pessimistic men. In fact, each increase in the level of optimism was
associated with an approximately 25% decreased risk of chest pain and heart
- Secrets to Aging
Gracefully - WebMD, 12/10/01 -
"the happiest respondents had minor physical
disabilities. They had regular social activities, could still think and
reason well, and had an overall feeling of well-being -- and those were
important to staying happy. In many cases, they were able to keep up
socially because they had spent a lot of time cultivating relationships with
friends and family when they were younger, and such investments in their
time paid big dividends in terms of avoiding depression and staying vital
later in life"
Vegetarian diet on solid ground, experts say - USA Today, 12/7/01 -
"McDougall points to a recent study in the Archives
of Internal Medicine that looked at Seventh-Day Adventists in California, a
group made up mostly of vegetarians. The 12-year of study of 34,192 people
found that on average, group members lived 10 years longer than the general
population ... Vegetarians have a 40% less risk of cancer and much less risk
of heart disease, diabetes, hypertension, kidney disease and other problems
that are common among meat eaters"
- Honing In on the
Fountain of Youth - WebMD, 9/25/01
Pitter-Patter Of Paws Is Time-Tested Remedy - Intelihealth, 7/24/01 -
article about how pets help you
"live longer, heal faster, lower blood pressure and
cholesterol and have a better chance of surviving a heart attack"
- Add a Decade to
Your Life - WebMD, 7/20/01 -
"Compared with other Californians, we found that
Adventist men lived about 7.3 years longer and women lived about 4.4 years
longer," Fraser tells WebMD. "And for vegetarian Adventists who eat meat [no
more than] once a month -- which accounts for about 30% Adventists -- the
differences in life expectancy swell to 9.5 years in men and 6.1 years in
women. Those are pretty big numbers."
- The Future is
Now: You Can Control How Well You Age, Depression, Education Key Factors
- WebMD, 6/1/01 -
"However, if the seven controllable factors are in
check, the only uncontrollable factor that is likely to wreak havoc with
your older years is depression"
Happy Thoughts May Prolong Life - Intelihealth, 5/8/01 -
"a 15-year study of aging and Alzheimer's disease in
nuns suggests a positive emotional state at an early age may help ward off
disease and even prolong life"
- Bad Health Habits
Would Be Taxing Under New Scheme - WebMD, 4/13/01 -
"nearly three-quarters of all disease in America
results from an "unhealthy lifestyle.""
- Here's to a Long
Life! Hormone Pathway That Controls Aging Discovered, Findings Suggest
Low-Cal Diet May Extend Lifespan - WebMD, 4/5/01
- Youth for Sale,
Antiaging Patients Looking, Feeling Good -- But Long-Term Safety Unknown
- WebMD, 10/13/00
Experiments Extend Life Of Nematode - Intelihealth, 9/1/00
- Gene Study May
Explain Why Low-Calorie Diet Slows Aging - WebMD, 6/28/00
Good habits now key to living longer, healthier life - CNN, 5/29/00
- Workaholism Can
Cause Mental, Physical Problems - WebMD, 5/5/00
Cloned Cows Cells Stay Young - Intelihealth, 4/28/00
Science takes cellular approach to explore aging process - CNN, 1/4/00
Staying Young Forever, Putting new research findings into practice -
Life Extension Foundation, 12/99
Good Health Habits Can Extend Life By About A Decade, Study Shows -
Herbs riding high, especially healthy ones - CNN, 11/3/99
Anti-aging nutrition secrets - CNN, 8/4/99
- FDA Joins Battle Against
Aging - Doctor's Guide, 2/27/97
QualityCounts.com Anti-aging Newsletter
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