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Home > Anti-aging Research > Longevity


News & Research:

  • How to Increase Your Chances of Having a Long, Healthy Life - NYT, 6/4/18 - "Dr. Murray said that medical practice also needs some serious tweaking. “Primary care providers are too focused on diagnosing disease and treating it,” he said. “They need to focus on the big contributors to risk, like high blood pressure and high cholesterol, which are easy to detect and easy to treat. Patients should demand it and, if they do, doctors will provide it.”"
  • The Surprising Secrets to Living Longer — And Better - Time, 2/19/18 - “It really is an issue of moderation,” says Peter Martin, a professor of human development and family studies at Iowa State University, who runs an ongoing study of centenarians. Martin notes that while most centenarians eat different but generally healthy diets, one consistent thing he has picked up from work with his 100-plus crowd is breakfast. “They rarely skip breakfast,” he says. “It’s often at a very specific time, and the routine is important.”
  • FDA-approved high blood pressure drug extends life span in roundworms - Science Daily, 12/20/17 - "This is the first report of hydralazine treatment activating the NRF2/SKN-1 signaling pathway. We found the drug extends the life span of worms as well as or better than other potential anti-aging compounds such as curcumin and metformin"
    • Hydralazine - wikipedia.org - "Common side effects include headache and fast heart rate.[1] It is not recommended in people with coronary artery disease or in those with rheumatic heart disease that affects the mitral valve.[1] In those with kidney disease a low dose is recommended ... It was patented in 1949 ... The wholesale cost in the developing world is about 2.78 to 9.11 USD per month ... Hydralazine is not used as a primary drug for treating hypertension because it elicits a reflex sympathetic stimulation of the heart (the baroreceptor reflex).[8] The sympathetic stimulation may increase heart rate and cardiac output, and in people with coronary artery disease may cause angina pectoris or myocardial infarction.[9] Hydralazine may also increase plasma renin concentration, resulting in fluid retention ... Prolonged treatment may cause a syndrome similar to lupus which can become fatal if the symptoms are not noticed and drug treatment stopped"
  • Towards natural mimetics of metformin and rapamycin - Aging (Albany NY). 2017 Nov 15 - "The analysis revealed many novel candidate metformin and rapamycin mimetics, including allantoin and ginsenoside (metformin), epigallocatechin gallate and isoliquiritigenin (rapamycin), and withaferin A (both)" - [Nutra USA] - See ginseng at Amazon.com and ashwagandha at Amazon.com.  See metformin at the Antiaging Store.
    • Withaferin A - wikipedia.org - "Withaferin A is a steroidal lactone, derived from Acnistus arborescens,[1] Withania somnifera[2] (Indian Winter cherry or Ashwagandha in Sanskrit) and other members of Solanaceae family"
  • An Hour of Running May Add 7 Hours to Your Life - NYT, 4/12/17 - "In concrete terms, an hour of running statistically lengthens life expectancy by seven hours"
  • Astaxanthin compound found to switch on the FOX03 'Longevity Gene' in mice - Science Daily, 3/28/17 -"The Astaxanthin compound CDX-085 (developed by Cardax) showed the ability to significantly increase the expression of the FOXO3 gene, which plays a proven role in longevity ... We found a nearly 90% increase in the activation of the FOXO3 "Longevity Gene" in the mice fed the higher dose of the Astaxanthin compound CDX-085" - See BioAstin at Amazon.com
  • Anti-Aging Effect of Riboflavin Via Endogenous Antioxidant in Fruit fly Drosophila Melanogaster - J Nutr Health Aging. 2017;21(3):314-31 - "Riboflavin prolonged the lifespan and increased the reproduction of fruit flies through anti-oxidative stress pathway involving enhancing the activity of SOD1 and CAT and inhibiting LF accumulation. Riboflavin deserves more attention for slowing human aging" - See riboflavin at Amazon.com.
  • High-sugar diet programs a short lifespan in flies - Science Daily, 1/11/17 - "Flies with a history of eating a high sugar diet live shorter lives, even after their diet improves. This is because the unhealthy diet drives long-term reprogramming of gene expression ... The FOXO gene is important for longevity in a wide variety of species, including yeast, flies, worms and humans, so the team say the findings may have broad implications"
  • Natural compound reduces signs of aging in healthy mice - Science Daily, 10/27/16 - "With age, the body loses its capacity to make a key element of energy production called NAD (nicotinamide adenine dinucleotide) ... Past research also has shown that NAD is not effective when given directly to mice so the researchers sought an indirect method to boost its levels. To do so, they only had to look one step earlier in the NAD supply chain to a compound called NMN (nicotinamide mononucleotide) ... NMN can be given safely to mice and is found naturally in a number of foods, including broccoli, cabbage, cucumber, edamame and avocado. The new study shows that when NMN is dissolved in drinking water and given to mice, it appears in the bloodstream in less than three minutes. Importantly, the researchers also found that NMN in the blood is quickly converted to NAD in multiple tissues ... The researchers found a variety of beneficial effects of NMN supplementation, including in skeletal muscle, liver function, bone density, eye function, insulin sensitivity, immune function, body weight and physical activity levels" - See NMN (nicotinamide mononucleotide) at Amazon.com.
  • Activation of the AMPK/Sirt1 pathway by a leucine-metformin combination increases insulin sensitivity in skeletal muscle, and stimulates glucose and lipid metabolism and increases life span in Caenorhabditis elegans - Metabolism. 2016 Jul 9 - "We have previously shown leucine (Leu) to activate Sirt1 by lowering its KM for NAD+, thereby amplifying the effects of other sirtuin activators and improving insulin sensitivity. Metformin (Met) converges on this pathway both indirectly (via AMPK) and by direct activation of Sirt1 ... Leu and Met synergize to enable Sirt1 activation at low NAD+ concentrations (typical of energy replete states). Sirt1 and AMPK activations are required for Met-Leu's full action, which result in improvements in energy metabolism and insulin sensitivity" - See BulkSupplements Pure L-Leucine Powder (1 Kilogram) and metformin at The Antiaging Store.
  • Pomegranate finally reveals its powerful anti-aging secret - Science Daily, 7/11/16 - "The team started out by testing their hypothesis on the usual suspect: the nematode C. elegans. It's a favorite test subject among aging experts, because after just 8-10 days it's already considered elderly. The lifespan of worms exposed to urolithin A increased by more than 45% compared with the control group ... These initial encouraging results led the team to test the molecule on animals that have more in common with humans. In the rodent studies, like with C. elegans, a significant reduction in the number of mitochondria was observed, indicating that a robust cellular recycling process was taking place. Older mice, around two years of age, showed 42% better endurance while running than equally old mice in the control group" - See pomegranate extract at Amazon.com.
  • Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway - J Gerontol A Biol Sci Med Sci. 2016 Jul 4 - "Coffee and tea, two of the most popular drinks around the world, share many in common from chemical components to beneficial effects on human health. One of their shared components, the polyphenols, most notably chlorogenic acid (CGA), was supposed to account for many of the beneficial effects on ameliorating diseases occurred accompanying people aging, such as the antioxidant effect and against diabetes and cardiovascular disease ... We found that CGA could extend the lifespan of C. elegans by up to 20.1%, delay the age-related decline of body movement, and improve stress resistance" - See chlorogenic acid at Amazon.com.
  • Fountain of youth? Dietary supplement may prevent and reverse severe damage to aging brain, research suggests - Science Daily, 6/2/16 - "contains common ingredients such as vitamins B, C and D, folic acid, green tea extract, cod liver oil and other nutraceuticals ... The mice used in this study had widespread loss of more than half of their brain cells, severely impacting multiple regions of the brain by one year of age, the human equivalent of severe Alzheimer's disease ... they also discovered that the mice on the supplements experienced enhancement in vision and most remarkably in the sense of smell -- the loss of which is often associated with neurological disease -- improved balance and motor activity" - See Garden of Life Vitamin Code 50 & Wiser Men's Multi, 240 Capsules and Garden of Life Vitamin Code 50 & Wiser Women's Multi, 240 Capsules.
  • Vitamin stops the aging process of organs - Science Daily, 4/28/16 - "As mice, like all mammals, age, the regenerative capacity of certain organs (such as the liver and kidneys) and muscles (including the heart) diminishes. Their ability to repair them following an injury is also affected. This leads to many of the disorders typical of aging ... We gave nicotinamide riboside to 2-year-old mice, which is an advanced age for them ... This substance, which is close to vitamin B3, is a precursor of NAD+, a molecule that plays a key role in mitochondrial activity. And our results are extremely promising: muscular regeneration is much better in mice that received NR, and they lived longer than the mice that didn't get it ... Parallel studies have revealed a comparable effect on stem cells of the brain and skin ... So far, no negative side effects have been observed following the use of NR, even at high doses" - See nicotinamide riboside at Amazon.com.
  • Lithium study helps scientists unlock ageing puzzle - BBC News, 4/7/16 - "fruit flies lived 16% longer than average when given low doses of lithium ... At high doses, lithium reduced their lifespan ... We found low doses not only prolong life but also shield the body from stress and block fat production for flies on a high sugar diet" - See lithium supplements at Amazon.com.
  • Scientific secrets for successful aging? - Science Daily, 3/29/16 - "Now that these age-related metabolites have been identified, the decline in antioxidants and muscle strength suggest that it is important for individuals to consume foods high in antioxidants and to continue exercising, especially after the age of 65. This could help increase the levels of the related metabolites in the body and improve body conditions"
  • Face cream ingredient found to mimic life-extending effects of a calorie restriction diet - Science Daily, 12/16/15 - "scientists have shown for the first time that allantoin, which is found in botanical extracts of the comfrey plant and is an ingredient of many anti-ageing creams, can mimic the effect of calorie restriction and increase lifespan in worms by more than 20% ... worms treated with allantoin, rapamycin, trichostatin A and LY-294002 not only lived longer, but also stayed healthier longer. Additionally, when the same compounds were tested in mutant worms they extended lifespan in a way expected from calorie restriction" - See allantoin products at Amazon.com.
  • Bone drug protects stem cells from aging - Science Daily, 12/17/15 - "the drug zoledronate is able to extend the lifespan of mesenchymal stem cells by reducing DNA damage ... DNA damage is one of the most important mechanisms of aging where stem cells lose their ability to maintain and repair the tissues in which they live and keep it working correctly"
  • Oleanolic acid activates daf-16 to increase lifespan in C.elegans - Biochem Biophys Res Commun. 2015 Nov 16 - "We investigate here whether OA has an impact on longevity in vivo, and more specifically, we have examined effects of OA on the lifespan and stress tolerance in Caenorhabditis elegans (C.elegans). Our results showed that OA could extend the lifespan, increase its stress resistance and reduce the intracellular reactive oxygen species (ROS) in wild-type worms. Moreover, we have found that OA-induced longevity may not be associated with the calorie restriction (CR) mechanism" - See oleanolic acid at Amazon.com.
    • Oleanolic acid - wikipedia.org - "Oleanolic acid can be found in olive oil, Phytolacca americana (American pokeweed), and Syzygium spp, garlic, etc."
  • Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans - Age (Dordr). 2015 Dec;37(6):113 - "Here, we show for first time that FA extends organism life span and causes a delay in aging. We observed that FA inhibits mechanistic target of rapamycin (mTOR) and insulin/insulin growth factor 1 (IGF-1) signaling pathways to control both oxidative stress levels and life span. The expression levels of stress- and life span-relevant gerontogenes, viz. daf-16, skn-1, and sir. 2.1, and oxidative enzymes, such as glutathione S-transferase 4 (GST-4) and superoxide dismutase 3 (SOD-3), were also found to be highly enhanced to attenuate the intracellular reactive oxygen species (ROS) damage and to delay the aging process. Our study promotes the use of FA to mitigate abiotic stresses and other aging-related ailments" - See folic acid products at Amazon.com.
  • Nutraceutical intervention reverses the negative effects of blood from aged rats on stem cells - Age (Dordr). 2015 Oct - "Aging is associated with a decline in function in many of the stem cell niches of the body. An emerging body of literature suggests that one of the reasons for this decline in function is due to cell non-autonomous influences on the niche from the body ... We examined if we could reverse this effect of aged serum on stem cell proliferation by treating aged rats with NT-020, a dietary supplement containing blueberry, green tea, vitamin D3, and carnosine that has been shown to increase neurogenesis in aged rats. Young and aged rats were administered either control NIH-31 diet or one supplemented with NT-020 for 28 days, and serum was collected upon euthanasia ... Serum from aged rats significantly reduced cell proliferation as measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and 5-bromo-2'-deoxyuridine (BrdU) assays in both NPCs and MSCs. Serum from aged rats treated with NT-020 was not different from serum from young rats. Therefore, NT-020 rescued the effect of serum from aged rats to reduce stem cell proliferation"
  • Are You Aging Faster Than Everyone Else? - NBC News, 7/7/15 - "as early as age 38, some people are biologically much older. In fact, some look like they're in their 60s, while others still look like 20-somethings ... Some of the people in our cohort had aged physiologically not at all between 26 and 38 ... At the other end of the extreme there were folks aging two to three times as much ... Their scores on the tests looked like people who are in their 50s and 60s ... The study members who appeared to be aging faster in their physiologies were also doing less well on the physical function ... We saw that already by age 38, study members whose physiologies were aging faster were showing signs of cognitive decline ... Perhaps most stunning, the aging-related changes showed up in people's faces"
  • Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trial - Nutr Metab Cardiovasc Dis. 2015 Mar 24 - "Compared to baseline, metformin significantly improved metabolic parameters and insulin sensitivity, increased SIRT1 gene/protein expression and SIRT1 promoter chromatin accessibility, elevated mTOR gene expression with concomitant reduction in p70S6K phosphorylation in subjects' PBMCs, and modified the plasma N-glycan profile. Compared to placebo, metformin increased SIRT1 protein expression and reduced p70S6K phosphorylation (a proxy of mTOR activity). Plasma N-glycans were also favourably modified by metformin compared to placebo" - See metformin at The Antiaging Store.
  • Hormone replacement therapy and longevity - Andrologia. 2015 Apr 19 - "It was found that testosterone replacement therapy of men suffering from late onset hypogonadism increased survival rate by 9-10% in 5 years, similar to that of eugonadal, non-LOH men with normal endogenous testosterone secretion. Oestrogen replacement therapy resulted in increased survival by 2.6% in 5 years. It is concluded that hormone replacement therapy increases longevity"
  • Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension? - Age (Dordr). 2015 Apr;37(2):9769 - "Both drugs significantly increased survivorship and maximal life span. Maximal longevity was 136 days for controls, 188 days (138 % of controls) for metformin, and 194 days (143 % of controls) for aspirin. Metformin and aspirin in combination extended longevity to a lesser degree (163 days, 120 % of controls)" - See metformin at The Antiaging Store.
  • New class of drugs dramatically increases healthy lifespan, mouse study suggests - Science Daily, 3/9/15 - "like cancer cells, senescent cells have increased expression of "pro-survival networks" that help them resist apoptosis or programmed cell death. This finding provided key criteria to search for potential drug candidates ... Using these criteria, the team homed in on two available compounds -- the cancer drug dasatinib (sold under the trade name Sprycel®) and quercetin, a natural compound sold as a supplement that acts as an antihistamine and anti-inflammatory ... The two compounds had different strong points. Dasatinib eliminated senescent human fat cell progenitors, while quercetin was more effective against senescent human endothelial cells and mouse bone marrow stem cells. A combination of the two was most effective overall ... In animal models, the compounds improved cardiovascular function and exercise endurance, reduced osteoporosis and frailty, and extended healthspan" - See quercetin at Amazon.com.
  • Ibuprofen Extends Life In Lab Species, Study Finds (Humans, Too?) - NBC News.com, 12/18/14 - "The ibuprofen administered to test subjects was comparable to recommended amounts for humans ... The treatments gave the organisms roughly 15 percent more life — equal to about 12 human years" - [Abstract] - See ibuprofen at Amazon.com.
  • Sugared soda consumption, cell aging associated in new study - Science Daily, 10/16/14 - "Regular consumption of sugar-sweetened sodas might influence disease development, not only by straining the body's metabolic control of sugars, but also through accelerated cellular aging of tissues ... Based on the way telomere length shortens on average with chronological age, the UCSF researchers calculated that daily consumption of a 20-ounce soda was associated with 4.6 years of additional biological aging. This effect on telomere length is comparable to the effect of smoking, or to the effect of regular exercise in the opposite, anti-aging direction"
  • Sense of Smell May Predict Longevity - NYTimes.com, 10/1/14 - "people who could not detect the odors were more than three times as likely to die within five years as those who could. The lower their scores on the odor test, the more likely they were to die. Only severe liver damage was a better predictor of death ... The researchers believe that the decline in the ability to smell is an indicator of some other age-related degeneration, and is not itself a cause of death"
  • Curcumin enhances parental reproductive lifespan and progeny viability in Drosophila melanogaster - Age (Dordr). 2014 Oct;36(5):9702 - "We have used the well-established model organism, Drosophila melanogaster, and ascertained the consequence of diet supplementation with curcumin. Flies reared on curcumin-supplemented diet had significantly higher lifespan. The progeny of flies reared on curcumin had a higher viability. The activity of a key mitochondrial enzyme-aconitase was significantly higher in flies reared on curcumin-supplemented diet. The results suggest that curcumin can not only correct a key step in the citric acid cycle and help in the release of additional energy but also permanently correct developmental and morphogenetic processes" - See curcumin products at Amazon.com.
  • Vitamin D: A Key to a Longer Life? - WebMD, 6/17/14 - "The researchers examined eight studies from Europe and the United States that together tracked more than 26,000 nonsmoking men and women ... Those with the lowest levels of vitamin D were about 1.5 times more likely than those with the highest levels to die from any cause and from heart disease during the periods of the studies. Those with low levels of vitamin D and a history of cancer were 1.7 times more likely to die of the disease ... It's not clear how vitamin D could help people live longer, but it might have something to do with the way it acts like a hormone" - See vitamin D at Amazon.com.
  • Anti-diabetic drug slows aging and lengthens lifespan, animal study suggests - Science Daily, 6/2/14 - "Metformin causes a slight increase in the number of harmful oxygen molecules. We found that this makes cells stronger and extends their healthy lifespan ... Other studies in humans have shown that metformin suppresses some cancers and heart disease. Metformin could even be an effective drug for counteracting the general effects of aging, say the researchers" - [Abstract] - See metformin at The Antiaging Store.
  • New tool to measure the speed of aging: Your handshake - Science Daily, 5/8/14 - "hand grip corresponds to other markers of aging such as people's future mortality, disability, cognitive decline and ability to recover from hospital stays"
  • Top 3 Foods for a Longer Life - ABC News, 4/21/14 - "resveratrol increases the activity of specific genes called sirtuins that protect against diseases of aging by revving up the mitochondria, the little batteries inside our cells ... mice fed the bacterial strain Bifidobacterium animalis lactis lived longer and were healthier than mice that did not receive the probiotic ... people who consume 650 mg a day of polyphenols live longer than those who get less then that" - See resveratrol products at Amazon.com and Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Older adults: Build muscle and you'll live longer - Science Daily, 3/14/14 - "The researchers analyzed data collected by the National Health and Nutrition Examination Survey (NHANES) III, conducted between 1988 and 1994. They focused on a group of 3,659 individuals that included men who were 55 or older and women who were 65 or older at the time of the survey. The authors then determined how many of those individuals had died from natural causes based on a follow-up survey done in 2004 ... They found that all-cause mortality was significantly lower in the fourth quartile of muscle mass index compared with the first quartile"
  • Supplement added to standard diet improves health, prolongs life in mice - Science Daily, 2/27/14 - "Activating a protein called sirtuin 1 extends lifespan, delays the onset of age-related metabolic diseases, and improves general health in mice ... tested the effects of a small molecule that activates SIRT1, called SIRT1720, on the health and lifespan of mice. The animals were fed a standard diet supplemented with 100 mg/kg SRT1720 beginning at 6 months of age for the remainder of their lives ... SRT1720 significantly extended the average lifespan of mice by 8.8%. Supplementation also reduced body weight and body fat percentage, and it improved muscle function and motor coordination throughout the animals' lives"
    • SRT1720 - Wikipedia - "SRT1720 is a drug developed by Sirtris Pharmaceuticals intended as a small-molecule activator of the sirtuin subtype SIRT1. It has similar activity in the body to the known SIRT1 activator resveratrol, but is 1000x more potent"
  • High Dietary Intake of Polyphenols Are Associated With Longevity - Science Daily, 10/9/13 - "the first to evaluate the total dietary polyphenol intake by using a nutritional biomarker and not only a food frequency questionnaire ... Polyphenols have antioxidant, antiinflammatory, anticarcinogenic, etc. effects ... based on a 12-year follow-up of a population sample composed by 807 men and women aged 65 or over from Greve and Bagno (Tuscany, Italy) ... the research proves that overall mortality was reduced by 30% in participants who had rich-polyphenol diets (>650 mg/day) in comparison with the participants who had low-polyphenol intakes (<500 mg/day)" - See Jarrow Formulas, OPCs + 95, 100 mg, 100 Capsules at iHerb.
  • Pill linked to long life in mice - BBC News, 7/31/13 - "Scientists believe the drug, metformin, may mimic the effects of extreme calorie restriction ... Metformin is one of the most widely prescribed treatments for type-2 diabetes, which occurs mainly in people above the age of 40. It is also used to treat metabolic syndrome, a combination of diabetes, high blood pressure and obesity ... The scientists gave one of two different doses of metformin to middle-aged male mice and found that lower doses increased lifespan by about 5%, and also delayed the onset of age-associated diseases" - Note:  I've been taking it in low doses for years to help combat aging.  See metformin at The Antiaging Store.
  • Rate of aging may be determined in the womb and linked to birthweight, study reveals - Science Daily, 7/9/13 - "a person's weight at the time of birth is an important determinant of health in middle and old age, and that people with low birth weight are more susceptible to age related diseases"
  • A Decreased Micronucleus Frequency in Human Lymphocytes after Folate and Vitamin B12 Intervention: a Preliminary Study in a Yunnan Population - Int J Vitam Nutr Res. 2012 Dec 1;82(6):374-382 - "Micronucleus (MN) is a validated biomarker for DNA damage in peripheral blood lymphocytes (PBL) and is a reflection of the changes of human nutritional status. Folate (FA) and vitamin B12 are one-carbon metabolism-related micronutrients, which play important roles in maintaining genomic stability ... Dietary supplement intake of FA and B12 based on MTHFR genotypes could protect the genome from damage and benefit genome health" - See folic acid products at Amazon.com and vitamin B12 at Amazon.com.
  • High Concentrations of a Urinary Biomarker of Polyphenol Intake Are Associated with Decreased Mortality in Older Adults - J Nutr. 2013 Jun 26 - "Polyphenols might have a role in the prevention of several chronic diseases, but evaluating total dietary polyphenol (TDP) intake from self-reported questionnaires is inaccurate and unreliable. A promising alternative is to use total urinary polyphenol (TUP) concentration as a proxy measure of intake. The current study evaluated the relationship between TUPs and TDPs and all-cause mortality during a 12-y period among older adult participants ... In the multivariable Cox model, participants in the highest tertile of TUP at enrolment had a lower mortality rate than those in the lowest tertile [HR = 0.70 (95% CI: 0.49-0.99); P-trend = 0.045], whereas no significant associations were found between TDP and overall mortality. TUP is an independent risk factor for mortality among community-dwelling older adults, suggesting that high dietary intake of polyphenols may be associated with longevity" - See Jarrow Formulas, OPCs + 95, 100 mg, 100 Capsules.
  • Herbal Extract Boosts Fruit Fly Lifespan by Nearly 25 Percent - Science Daily, 6/18/13 - "Rhodiola works in a manner completely unrelated to dietary restriction and affects different molecular pathways ... Rhodiola can act even in individuals who are already long-lived and healthy. This is quite unlike resveratrol, which appears to only act in overfed or unhealthy individuals ... Not only did Rhodiola improve lifespan an average of 24 percent in both sexes and multiple strains of flies, but it also delayed the loss of physical performance in flies as they aged and even extended the lives of old flies ... Rhodiola has already shown possible health benefits in humans, such as decreasing fatigue, anxiety and depression; boosting mood, memory and stamina; and preventing altitude sickness" - See Rhodiola rosea at Amazon.com.
  • Calcium Supplements Linked to Longer Lifespans in Women - Science Daily, 5/22/13 - "Researchers analyzing data from the large-scale Canadian Multicentre Osteoporosis Study (CaMos) sought to clarify this issue and found moderate doses of calcium supplements had a beneficial effect in women ... The benefit was seen for women who took doses of up to 1,000 mg per day, regardless of whether the supplement contained vitamin D ... there was no statistical benefit for men ... the same benefits were seen when the calcium came from dairy foods, non-dairy foods or supplements"
  • How diabetes drug delays aging in worms - Science Daily, 3/28/13 - "Following a calorie-restricted diet has been shown to improve health in later life and extend lifespan in a number of animals, ranging from the simple worm to rhesus monkeys. The type 2 diabetes drug metformin has been found to have similar effects in animals ... Overall, treatment with metformin adds up to 6 days of life for the worm which is equivalent to around a third of its normal lifespan. It seems to work by altering metabolism in the bacteria that live in the worm, which in turn limits the nutrients that are available to the worm host and has a similar effect to restricting the diet ... However, when they added an excess of sugar to the diet, the team found that the life-extending effects of metformin were cancelled out" - See metformin at The Antiaging Store.
  • Anti-aging drug breakthrough - Science Daily, 3/8/13 - "Drugs that combat aging may be available within five years ... The target enzyme, SIRT1, is switched on naturally by calorie restriction and exercise, but it can also be enhanced through activators. The most common naturally-occurring activator is resveratrol, which is found in small quantities in red wine, but synthetic activators with much stronger activity are already being developed ... While any drug would be strictly prescribed for certain conditions, Professor Sinclair suggests that one day, they could be taken orally as a preventative ... overweight mice given synthetic resveratrol were able to run twice as far as slim mice and they lived 15 per cent longer" - Note:  They've been saying that five year thing ever since I've been reading health articles.  In the mean time, see resveratrol products at Amazon.com.
  • Baby Boomers' Overall Health Worse Than Their Parents - Medscape, 2/4/13 - "Despite their longer life expectancy over previous generations, US baby boomers have higher rates of chronic disease, more disability, and lower self-rated health than members of the previous generation at the same age ... As to comparative disability, more than twice as many baby boomers used walking assist devices (6.9% vs 3.3%), more were limited in their work by disability (13.8% vs 10.1%), and 13.5% vs 8.8% were coping with some type of functional limitation ... In addition, more baby boomers are obese compared with the previous generation (38.7% vs 29.4%), and they reported exercising significantly less often (35.0% vs 49.9% exercised >12 times per month) ... Moderate drinking was more common among the boomers compared with the previous generation (67.3% vs 37.2%) ... Hypertension, too, was more common (43.0% vs 36.4%) ... the present study demonstrates a clear need for policies that expand efforts at prevention and healthy lifestyle promotion in the baby boomer generation"
  • Hydrogen sulfide: The next anti-aging agent? - Science Daily, 1/29/13 - "Hydrogen sulfide* (H2S) may play a wide-ranging role in staving off aging ... Hydrogen sulfide is produced within the human body, and has a variety of important physiological effects. For example, it relaxes the vascular endothelium and smooth muscle cells, which is important to maintaining clean arteries as one ages ... It functions as an antioxidant. And it inhibits expression of pro-inflammatory factors, all of which "imply an important role in aging and age-associated diseases," ... Produced in the kidneys, it has direct angiotensin-converting enzyme (ACE) inhibiting activity; that is, it's an ACE inhibitor, just like certain drugs that mitigate high blood pressure. Not surprisingly, plasma H2S declines with age, and is lower in spontaneously hypertensive rats than in those with normal blood pressure. More generally, a lack of H2S is implicated in cardiovascular disease"
  • Healthy living adds fourteen years to your life, study suggests - Science Daily, 11/5/12 - "researchers pulled data from five different cohorts included in the Cardiovascular Lifetime Risk Pooling Project and looked at the participants' risk of all forms of fatal and nonfatal cardiovascular disease from ages 45, 55 and 65 through 95 years of age ... Individuals with optimal risk factor profiles lived up to 14 years longer free of total CVD than individuals with at least two risk factors ... Men in middle age had lifetime risks of approximately 60 percent for developing cardiovascular disease ... Women in middle age had lifetime risks of approximately 56 percent for developing cardiovascular disease ... Lifetime risks for cardiovascular disease were strongly associated with risk factor burden in middle age"
  • Acai counteracts oxidative stress, lengthens lifespan in fruit flies - Science Daily, 8/21/12 - "a commercially available acai berry product can lengthen the lives of fruit flies, when the flies' lives are made short through additional oxidative stress. Under certain conditions (a simple sugar diet) acai supplementation could triple flies' lifespans, from eight to 24 days. Acai could also counteract the neurotoxic effects of the herbicide paraquat on the flies ... Acai berries contain a variety of antioxidant and anti-inflammatory compounds, such as anthocyanins" - See acai berry products at Amazon.com.
  • Regular jogging shows dramatic increase in life expectancy - Science Daily, 5/3/12 - "Results show that in the follow-up period involving a maximum of 35 years, 10,158 deaths were registered among the non-joggers and 122 deaths among the joggers. Analysis showed that risk of death was reduced by 44% for male joggers (age-adjusted hazard ratio 0.56) and 44% for female joggers (age-adjusted hazard ratio 0.56) ... Furthermore the data showed jogging produced an age adjusted survival benefit of 6.2 years in men and 5.6 years in women. Further analysis exploring the amounts of exercise undertaken by joggers in the study has revealed a U-shaped curve for the relationship between the time spent exercising and mortality. The investigators found that between one hour and two and a half hours a week, undertaken over two to three sessions, delivered the optimum benefits, especially when performed at a slow or average pace ... The ideal pace can be achieved by striving to feel a little breathless. "You should aim to feel a little breathless, but not very breathless," ... It improves oxygen uptake, increases insulin sensitivity, improves lipid profiles (raising HDL and lowering triglycerides), lowers blood pressure, reduces platelet aggregation, increases fibrinolytic activity, improves cardiac function, bone density, immune function, reduces inflammation markers, prevents obesity, and improves psychological function"
  • Study resolves controversy on life-extending red wine ingredient, restores hope for anti-aging pill - Science Daily, 5/1/12 - "The new findings show for the first time that the metabolic benefits of the red wine ingredient known as resveratrol evaporate in mice that lack the famed longevity gene SIRT1 ... They show that resveratrol targets SIRT1 directly at moderate doses and hits other targets at higher ones. Importantly, SIRT1 is required for resveratrol's benefits irrespective of dose" - See resveratrol products at Amazon.com.
  • Tiny amounts of alcohol dramatically extend a worm's life, but why? - Science Daily, 1/20/12 - "How little ethanol is that? ... The concentrations correspond to a tablespoon of ethanol in a bathtub full of water or the alcohol in one beer diluted into a hundred gallons of water ... The scientists found that when they raised the ethanol level by a factor of 80, it did not increase the life span of the worms"
  • Simple lifestyle changes can add a decade or more healthy years to the average lifespan, Canadian study shows - Science Daily, 10/22/11 - "Achieving these seven simple lifestyle factors gives people a 90 per cent chance of living to the age of 90 or 100, free of not only heart disease and stroke but from a number of other chronic illnesses including cancer ... 1. GET ACTIVE ... 2. KNOW AND CONTROL CHOLESTEROL LEVELS ... 3. FOLLOW A HEALTHY DIET ... 4. KNOW AND CONTROL BLOOD PRESSURE ... 5. ACHIEVE AND MAINTAIN A HEALTHY WEIGHT ... 6. MANAGE DIABETES ... 7. BE TOBACCO FREE"
  • Why muscles weaken with age and points to possible therapy - Science Daily, 8/2/11 - "As we grow older, our skeletal muscles tend to wither and weaken, a phenomenon known as sarcopenia. Sarcopenia, which begins to appear at around age 40 and accelerates after 75, is a major cause of disability in the elderly. Exercise can help counter the effects of age-related muscle loss ... Both the aging process and the genetic defect responsible for muscular dystrophy cause an increase in the production of oxygen free radicals, highly reactive and harmful molecules. "Our data suggest that this sets up a vicious cycle, in which the free radicals cause ryanodine receptors to leak calcium into the cell. The calcium poisons mitochondria -- organelles that power the cell -- leading to the release of even more free radicals. This, in turn, causes more calcium leakage. With less calcium available for contraction, the muscles get weaker," ... The study also points to a possible therapy for sarcopenia: an experimental drug called S107 ... "Most investigators in the field of aging have been saying that the way to improve muscle strength is to build muscle mass, using such therapies as testosterone, growth hormone, and insulin-like growth factor-1," says Dr. Marks. "But an increase in muscle mass is not necessarily accompanied by an increase in muscle function"
  • U.S. Death Rate Hits Record Low - WebMD, 3/16/11 - "The 15 leading causes of death in 2009 and the decreases in associated death rates were reported as follows: ... 1.Heart disease: 3.7% ... 2.Cancer: 1.1% ... 3.Chronic lower respiratory diseases: 4.1% ... 4.Stroke: 4.2% ... 5.Accidents: 4.1% ..."
  • Keys to long life? Not what you might expect - Science Daily, 3/12/11 - ""Don't work too hard, don't stress," doesn't work as advice for good health and long life. Subjects who were the most involved and committed to their jobs did the best. Continually productive men and women lived much longer than their more laid-back comrades ... "One of the findings that really astounds people, including us, is that the Longevity Project participants who were the most cheerful and had the best sense of humor as kids lived shorter lives, on average, than those who were less cheerful and joking. It was the most prudent and persistent individuals who stayed healthiest and lived the longest." ... Part of the explanation lies in health behaviors -- the cheerful, happy-go-lucky kids tended to take more risks with their health across the years, Friedman noted. While an optimistic approach can be helpful in a crisis, "we found that as a general life-orientation, too much of a sense that 'everything will be just fine' can be dangerous because it can lead one to be careless about things that are important to health and long life. Prudence and persistence, however, led to a lot of important benefits for many years"
  • Can Exercise Keep You Young? - NYTimes.com, 3/2/11 - "in heartening new research published last week in The Proceedings of the National Academy of Sciences, exercise reduced or eliminated almost every detrimental effect of aging in mice that had been genetically programmed to grow old at an accelerated pace ... mitochondria can accumulate small genetic mutations, which under normal circumstances are corrected by specialized repair systems within the cell. Over time, as we age, the number of mutations begins to outstrip the system’s ability to make repairs, and mitochondria start malfunctioning and dying ... Half of the mice were allowed to run on a wheel for 45 minutes three times a week, beginning at 3 months ... At 8 months, when their sedentary lab mates were bald, frail and dying, the running rats remained youthful. They had full pelts of dark fur, no salt-and-pepper shadings. They also had maintained almost all of their muscle mass and brain volume. Their gonads were normal, as were their hearts. They could balance on narrow rods, the showoffs ... But perhaps most remarkable, although they still harbored the mutation that should have affected mitochondrial repair, they had more mitochondria over all and far fewer with mutations than the sedentary mice had"
  • Happiness improves health and lengthens life - Science Daily, 3/1/11 - "We reviewed eight different types of studies ... the general conclusion from each type of study is that your subjective well-being -- that is, feeling positive about your life, not stressed out, not depressed -- contributes to both longevity and better health among healthy populations ... Laboratory experiments on humans have found that positive moods reduce stress-related hormones, increase immune function and promote the speedy recovery of the heart after exertion. In other studies, marital conflicts and high hostility in married couples were associated with slow wound healing and a poorer immune response"
  • Fountain of youth from the tap? Environmental lithium uptake promotes longevity, scientists demonstrate in worms - Science Daily, 2/18/11 - "A regular uptake of the trace element lithium can considerably promote longevity ... even a low concentration of lithium leads to an increased life expectancy in humans as well as in a model organism, the roundworm Caenorhabditis elegans ... the Jena scientists analyzed the mortality rate in 18 adjacent Japanese municipalities in relation to the amount of lithium contained in tap water from the respective regions. "We found that the mortality rate was considerably lower in those municipalities with more lithium in the drinking water," Ristow explains the key finding. In a second experiment, the Jena scientists examined exactly this range of concentration in the model organism C. elegans. The result was confirmed: "The average longevity of the worms is higher after they have been treated with lithium at this dosage," ... we know already that a higher uptake of lithium through drinking water is associated with an improvement of psychological well-being and with decreased suicide rates" - See lithium products at iHerb.
  • Eat fiber, live longer - MSNBC, 2/14/11 - "Most Americans aren't getting enough roughage in their diets. The average American eats only about 15 grams of fiber each day, much less than the current daily recommendation of 25 grams for women and 38 grams for men, or 14 grams per 1,000 calories. For example, a slice of whole wheat bread contains 2 to 4 grams of fiber ... In the new study, the people who met the guidelines were less likely to die during a nine-year follow-up period ... The men and women who ate the highest amount of fiber were 22 percent less likely to die from any cause compared to those who ate the lowest amount"
  • Relation Between High-Density Lipoprotein Cholesterol and Survival to Age 85 Years in Men (from the VA Normative Aging Study) - Am J Cardiol. 2011 Feb 4 - "We categorized initial HDL cholesterol into <40 mg/dl (reference group), 40 to 49 mg/dl, or ≥50 mg/dl ... Treating HDL cholesterol as a continuous predictor, we also determined the HR for each 10-mg/dl increment in HDL cholesterol. Fully adjusted HR (95% confidence interval) for survival to 85 years of age for participants with an initial HDL cholesterol level ≥50 mg/dl compared to the reference was 0.72 (0.53 to 0.98). Each 10-mg/dl increment in HDL cholesterol was associated with a 14% (HR 0.86, 0.78 to 0.96) decrease in risk of mortality before 85 years of age. In conclusion, after adjusting for other factors associated with longevity, higher HDL cholesterol levels were significantly associated with survival to 85 years of age" - See niacin at Amazon.com (niacin increases HDL).
  • Smoking, obesity to blame for lag in U.S. lifespan - MSNBC/Associated Press, 1/25/11 - "The U.S. spends more on health care than any other nation yet has worse life expectancy than many — and a new report blames smoking and obesity ... That may sound surprising, considering that public smoking is being stamped out here while it's common in parts of Europe. And obesity is a growing problem around the world ... But the U.S. led those unhealthy trends, lighting up and fattening up a few decades ahead of other high-income countries. And the long-term consequences are life expectancy a few years shorter than parts of Europe and Japan"
  • High alpha-carotene levels associated with longer life - Science Daily, 11/22/10 - "Oxygen-related damage to DNA, proteins and fats may play a role in the development of chronic diseases like heart disease and cancer ... Carotenoids -- including beta-carotene, alpha-carotene and lycopene -- are produced by plants and microorganisms and act as antioxidants, counteracting this damage ... Compared with individuals with blood alpha-carotene levels between 0 and 1 micrograms per deciliter, the risk of death during the study period was 23 percent lower among who had concentrations between 2 and 3 micrograms per deciliter, 27 percent lower with levels between 4 and 5 micrograms per deciliter, 34 percent lower with levels between 6 and 8 micrograms per deciliter and 39 percent lower with levels of 9 micrograms per deciliter or higher" - Note:  There are over 600 carotenoids and some claim that taking large amounts of just one of them can cause a deficiency of the others.  See Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.com.
  • Regular exercise reduces large number of health risks including dementia and some cancers, study finds - Science Daily, 11/15/10 - "Regular exercise can reduce around two dozen physical and mental health conditions and slow down how quickly the body ages ... Health conditions covered by the review include: cancer, heart disease, dementia, stroke, type 2 diabetes, depression, obesity and high blood pressure"
  • US Hispanics Have Longer Life Expectancy Than White and Black Americans - ABC News, 10/14/10 - "long-term health has a lot to do with diet, and immigrants are far less likely to indulge in the types of fattening foods that have expanded the American waistline. Instead of fast food and processed products, immigrants tend to favor fruit, vegetables, rice and beans ... Experts add that Hispanic immigrants eat far less red meat, instead consuming less-expensive chicken ... Besides a healthy diet, Hispanic immigrants also have the strong social bonds with family and friends that longevity experts say promote a long and happy life -- including drinking and smoking less ... If you lose that family connectedness, then you tend to have more health problems ... The people across the board who live oldest and healthiest are people who are part of social networks" - Should they have added exercise to that? I’ve never seen any statistics but I think Hispanics might have on average more physically demanding jobs. I saw a study several years ago where postal workers that delivered mail door to door lived longer than postal workers in an office. I run or swim and hour and a half a day but when I take on a large project on my house I’m a lot sorer and start losing a pant size per week.
  • Amino acid supplement makes mice live longer - Science Daily, 10/5/10 - "leucine, isoleucine, and valine extend the life span of single-celled yeast ... Animals that were given the extra amino acids over a period of months lived longer, with a median life span of 869 days compared to 774 days for untreated control animals, the researchers report. That's an increase of 12 percent ... The findings in older mice suggest that the supplementary mixture may be specifically beneficial for those who are elderly or ill" - See BCAA products at Amazon.com, it contains the three of these.
  • Women's study finds longevity means getting just enough sleep - Science Daily, 9/30/10 - "the secret to a long life may come with just enough sleep. Less than five hours a night is probably not enough; eight hours is probably too much ... sleeping 6.5 to 7.5 hours per night was associated with best survival ... when sleep was measured objectively, the best survival was observed among women who slept 5 to 6.5 hours ... Women who slept less than five hours a night or more than 6.5 hours were less likely to be alive at the 14-year follow-up"
  • Some interesting info on telomeres that someone sent:
    • Telomere Length Linked to Outcomes in Aplastic Anemia - nih.gov, 9/27/10 - "Aplastic anemia patients with shorter chromosome tips, or telomeres, have a lower survival rate and are much more likely to relapse after treatment than those with longer telomeres ... the blood cells of some patients with severe aplastic anemia disease have extremely short telomeres ... nearly 60% of the patients responded to immunosuppressive therapy. Of those who responded, the patients with the shortest telomeres were most likely to have a later relapse. The scientists found that the rate of relapse dropped as telomere lengths increased ... The group of patients with the shortest telomeres was also at greater risk for a conversion to bone marrow cancer (24%) than the other 3 groups (3% to 13%). Survival rates differed as well. Only 66% of patients with the shortest telomeres survived at least 6 years, compared to an 84% survival rate for the other 3 groups combined"
    • Happy Healthy Long Life: There's No Way Around It: If You Want to Live Longer You've Just Got to Do It! Get Out There & Exercise! - 2/6/08 - "by the time you're 65, well, there's just not that much left. Which is exactly why not too many of us make it past 80, 90 or 100. Not to get you even more depressed about your rapidly shrinking telomeres, but there have been a number of studies that have shown how stress, especially in caregiver's of chronically ill children and spouses of Alzheimer's patients have accelerated telomere shrinking. One study even suggested that you can accelerate your biological age by as much as 17 years if you're exposed to what you perceive as high psychological stress! ... it looks as if it's a safe bet to start lengthening your telomeres now, by EXERCISING!"
  • Coffee may protect against DNA damage: Study - Nutra USA, 9/7/10 - "coffee is one of the richest sources of polyphenols in the Western diet, with one cup of the stuff providing 350 milligrams of phenolics. Of these, the most abundant compounds coffee are chlorogenic acids, making up to 12 per cent of the green coffee bean. The most abundant of these compounds is caffeic acid ... The subjects were assigned to drink either 800 ml coffee or water daily for five days. Various measures of DNA damage were used ... At the end of the study, a reduction in DNA damage, as measured by a reduction in the formation of oxidised purines of 12.3 percent was observed in the coffee drinkers" -  [Abstract]
  • Impact of paper filtered coffee on oxidative DNA-damage: Results of a clinical trial - Mutat Res. 2010 Aug 13 - "consumed 800ml coffee or water daily over 5 days ... The extent of DNA-migration attributable to formation of oxidised purines (formamidopyrimidine glycosylase sensitive sites) was decreased after coffee intake by 12.3%"
  • Resveratrol May Slow Aging in Humans - Medscape, 8/6/10 - "the popular plant extract has been shown to prolong life and reduce the rate of aging in roundworms, fruit flies, and yeast, apparently because resveratrol affects a gene associated with longevity ... resveratrol suppressed the generation of “free radicals” -- unstable molecules known to cause oxidative stress and release pro-inflammatory substances into the blood, resulting in damage to the blood vessel lining ... resveratrol also showed suppression of the inflammatory protein tumor necrosis factor, or TNF, and other compounds that increase blood vessel inflammation and interfere with insulin action, causing insulin resistance and the risk of developing diabetes" - See resveratrol products at Amazon.com.
  • Aging and longevity tied to specific brain region in mice - Science Daily, 7/28/10 - "mice with increased brain SIRT1 have internal mechanisms that make them use energy more efficiently, which helps them move around in search of food even after a long fast. This increased energy-efficiency could help delay aging and extend lifespan ... SIRT1 is at the center of a network that connects metabolism and aging" - Related articles on SIRT1:

    • Sirtuin1 may boost memory and learning ability; Discovery could lead to new drugs to fight Alzheimer's, other neurological diseases - Science Daily, 7/11/10 - "Resveratrol, found in wine, has been touted as a life-span enhancer because it activates a group of enzymes known as sirtuins, which have gained fame in recent years for their ability to slow the aging process. Now MIT researchers report that Sirtuin1 -- a protein that in humans is encoded by the SIRT1 gene -- also promotes memory and brain flexibility ... We have now found that SIRT1 activity also promotes plasticity and memory"
    • Slowing Aging: Anti-aging Pathway Enhances Cell Stress Response - Science Daily, 2/19/09 - "The researchers discovered a new molecular relationship critical to keeping cells healthy across a long span of time: a protein called SIRT1, important for caloric restriction and lifespan and activated by resveratrol, regulates heat shock factor 1 (HSF1), keeping it active. HSF1 in turn senses the presence of damaged proteins in the cell and elevates the expression of molecular chaperones to keep a cell's proteins in a folded, functional state. Regulation of this pathway has a direct beneficial effect to cells ... decrease in SIRT1 may help explain why protein misfolding diseases, such as Alzheimer's, Parkinson's, Huntington's and adult-onset diabetes, are diseases of aging"
    • Drug 'tricks body to lose weight' - BBC News, 11/5/08 - "The drug SRT1720 - a chemical cousin of red wine extract resveratrol - targets the protein SIRT1, which is thought to combat ageing ... The French team from the University Louis Pasteur became interested in the SIRT1 protein after earlier studies showing resveratrol countered some effects of a high-calorie diet via SIRT1" - See resveratrol at Amazon.com.
    • Wine Compound Spurs Diabetes Research - WebMD, 11/29/07 - "In October, Chinese researchers reported that resveratrol curbs insulin resistance in mice. Insulin is a hormone that controls blood sugar. Insulin resistance can lead to type 2 diabetes ... Like resveratrol, the lab-made chemicals activate a gene called SIRT1, making the diabetic mice more sensitive to insulin ... the newly developed chemicals are 1,000 times more potent than resveratrol"
    • Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner - Am J Clin Nutr. 2010 May 12 - "Taken together, our data suggest that resveratrol influences adipose tissue mass and function in a way that may positively interfere with the development of obesity-related comorbidities. Thus, our findings open up the new perspective that resveratrol-induced intracellular pathways could be a target for prevention or treatment of obesity-associated endocrine and metabolic adverse effects"
    • Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation - J Agric Food Chem. 2009 Nov 20 - "Similar to those effects associated with caloric restriction (CR), resveratrol has multiple beneficial activities, such as increased life span and delay in the onset of diseases associated with aging ... Here, we show that resveratrol activated AMPK in both ER-positive and ER-negative breast cancer cells ... Here, we show that resveratrol activated AMPK in both ER-positive and ER-negative breast cancer cells. Once activated, AMPK inhibited 4E-BP1 signaling and mRNA translation via mammalian target of rapamycin (mTOR). Moreover, we also found that AMPK activity mediated by resveratrol in cancer cells was due to inducing the expression of Sirtuin type 1 (SIRT1) via elevation in the cellular NAD(+)/NADH in ER-positive cells. To our knowledge, we demonstrate here for the first time that resveratrol induces the expression of SIRT1 protein in human cancer cells. These observations raise the possibility that SIRT1 functions as a novel upstream regulator for AMPK signaling and may additionally modulate tumor cell proliferation. Targeting SIRT1/AMPK signaling by resveratrol may have potential therapeutic implications for cancer and age-related diseases"
    • Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway - Biochem Biophys Res Commun. 2009 Mar 13;380(3):644-9 - "Our results suggest that resveratrol may attenuate fat deposition by inhibiting SREBP1 expression via Sirt1-FOXO1 pathway and thus may have application for the treatment of NAFLD"
    • Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1-FoxO1 pathway - Biochem Biophys Res Commun. 2008 Dec 3 - "Loss of cardiomyocytes through apoptosis has been proposed as a cause of ventricular remodeling and heart failure. Ischemia- and hypoxia-induced apoptosis of cardiomyocytes reportedly plays an important role in many cardiac pathologies. We investigated whether resveratrol (Res) has direct cytoprotective effects against ischemia/hypoxia for cardiomyocytes. Exposure of H9c2 embryonic rat heart-derived cells to hypoxia for 24h caused a significant increase in apoptosis, as evaluated by TUNEL and flow cytometry, while treatment with 20muM Res greatly decreased hypoxia-induced apoptosis in these cells. Exposure of the cells to Res (20muM) caused rapid activation of SIRT1, which had a dual effect on FoxO1 function: SIRT1 increased FoxO1's ability to induce cell cycle arrest, but inhibited FoxO1's ability to induce cell death. This effect could be reversed by SIRT1 inhibition. Results of our study indicate that Res inhibits hypoxia-induced apoptosis via the SIRT1-FoxO1 pathway in H9c2 cells. This polyphenol may have potential in preventing cardiovascular disease, especially in coronary artery disease (CAD) patients"
  • Calorie restriction: what recent results suggest for the future of ageing research - Eur J Clin Invest. 2010 May;40(5):440-50 - "the search for substances that can reproduce the beneficial physiologic responses of CR without a requisite calorie intake reduction, termed CR mimetics (CRMs), has gained momentum. Material and methods Recent articles describing health and lifespan results of CR in nonhuman primates and short-term human studies are discussed. Additional consideration is given to the rapidly expanding search for CRMs. Results The first results from a long-term, randomized, controlled CR study in nonhuman primates showing statistically significant benefits on longevity have now been reported. Additionally, positive results from short-term, randomized, controlled CR studies in humans are suggestive of potential health and longevity gains, while test of proposed CRMs (including rapamycin, resveratrol, 2-deoxyglucose and metformin) have shown both positive and mixed results in rodents"
  • Eat less, live longer? - New Scientist, 6/3/10 - "One piece of evidence for this idea comes from studies in fruit flies and rodents. If these animals are fed special diets with less amino acids - the building blocks of proteins - they can eat as many calories as they want and still live longer ... The protein theory is bad news for people on low-carbohydrate weight-loss plans like the Atkins diet. "I'd be wary of diets that put a heavy emphasis on protein," says Piper. "It's hard to see how that could be healthy." Fontana goes one step further, saying that high-protein diets could risk accelerated ageing and cancer ... There may be another reason for vegans to celebrate. Studies on flies and rodents suggest that cutting intake of one particular amino acid, called methionine, lengthens life to a similar degree as calorie restriction. Proteins in meat and other animal products have high levels of methionine, so a vegan diet would score well by that measure, too"
  • 15 best age-erasing superfoods - MSNBC, 5/25/10 - "Yogurt ... Various cultures claim yogurt as their own creation, but the 2,000-year-old food’s health benefits are not disputed: Fermentation spawns hundreds of millions of probiotic organisms that serve as reinforcements to the battalions of beneficial bacteria in your body, which keep your digestive tract healthy and your immune system in top form, and provide protection against cancer. Not all yogurts are probiotic, though, so make sure the label says “live and active cultures.”"
  • Phosphorous in sodas and processed foods accelerates signs of aging, study suggests - Science Daily, 4/26/10 - "high levels of phosphates may add more "pop" to sodas and processed foods than once thought. That's because researchers found that the high levels of phosphates accelerate signs of aging. High phosphate levels may also increase the prevalence and severity of age-related complications, such as chronic kidney disease and cardiovascular calcification, and can also induce severe muscle and skin atrophy"
  • Excessive alcohol consumption may lead to increased cancer risk - Science Daily, 4/21/10 - "Researchers have detected a link between alcohol consumption, cancer and aging that starts at the cellular level with telomere shortening ... Telomeres are found at the region of DNA sequences at the end of a chromosome, and are important for the genetic stability of cells. As people age, telomere length shortens progressively ... Since telomere shortening is thought to increase cancer risk, the researchers speculated that those with shorter telomeres due to heavy alcohol consumption would have an increased risk of cancer ... telomere length was dramatically shortened in those who consumed heavy amounts of alcohol; telomere length was nearly half as long as telomere length in the non-abusers (0.41 vs. 0.79 relative units)"
  • Anti-aging hormones: Little or no benefit and the risks are high, according to experts - Science Daily, 4/13/10
  • Vitamin combo may delay ageing: Mouse study - Nutra USA, 3/1/10 - "Results showed maintenance of youthful levels of locomotor activity into old age in the supplemented animals, whereas old non-supplemented mice showed a 50 per cent loss in daily movement, said the researchers. This was accompanied by a loss of mitochondria activity, and declines in brain signalling chemicals relevant to locomotion, such as striatal neuropeptide Y. This chemical is associated with a range of functions, including maintaining energy balance, as well as effects in memory and learning ... No such declines were observed in supplemented animals ... The supplement was composed of vitamins B1, B3 (niacin), B6, B12, C, D, E, folic acid, beta-carotene, CoQ10, rutin, bioflavonoids, ginko biloba, ginseng, green tea extract, ginger root extract, garlic, L-Glutathione, magnesium, selenium, potassium, manganese, chromium picolinate, acetyl L-carnitine, melatonin, alpha-lipoic acid, N-acetyl cysteine, acetylsalicylic acid, cod liver oil, and flax seed oil"
  • Dietary formula that maintains youthful function into old age - Science Daily, 2/12/10 - "Using bagel bits soaked in the supplement to ensure consistent and accurate dosing, the formula maintained youthful levels of locomotor activity into old age whereas old mice that were not given the supplement showed a 50 per cent loss in daily movement, a similar dramatic loss in the activity of the cellular furnaces that make our energy, and declines in brain signaling chemicals relevant to locomotion. This builds on the team's findings that the supplement extends longevity, prevents cognitive declines, and protects mice from radiation ... Ingredients consists of items that were purchased in local stores selling vitamin and health supplements for people, including vitamins B1, C, D, E, acetylsalicylic acid, beta carotene, folic acid, garlic, ginger root, ginkgo biloba, ginseng, green tea extract, magnesium, melatonin, potassium, cod liver oil, and flax seed oil" - Sounds like most of what I'm already taking. - Ben
  • Overweight Older People Live Longer - WebMD, 1/28/10 - "people who met the criteria for being overweight were 17% less likely to die compared to people of normal weight ... In the newly reported research, overweight study participants in their 70s followed for up to 10 years had a 13% lower risk of death than participants classified as normal weight ... Obese and normal-weight study participants had a similar risk of death over the 10 years of follow-up. Underweight study participants had the highest risk of death, even after the researchers adjusted for the wasting effects of disease"
  • 10 surprising ways to live longer - MSNBC, 1/5/10 - "Eat omega-3s every day ... Sniff lavender or rosemary ... Don’t be a drama queen ... Stop eating before you’re stuffed ... Stay the weight you were at 18 ... Diversify your workout ... Munch on veggies or fruits every 4 hours ... Floss daily ... Have a standing lunch date ... Donate blood"
  • Calorie restriction: Scientists take important step toward 'fountain of youth' - Science Daily, 12/26/09 - "They found that the normal cells lived longer, and many of the precancerous cells died, when given less glucose. Gene activity was also measured under these same conditions. The reduced glucose caused normal cells to have a higher activity of the gene that dictates the level of telomerase, an enzyme that extends their lifespan and lower activity of a gene (p16) that slows their growth. Epigenetic effects (effects not due to gene mutations) were found to be a major cause in changing the activity of these genes as they reacted to decreased glucose levels" - See my Insulin and Aging page.  Insulin controls glucose levels.  Insulin resistance causes high glucose.
  • Look Young to Live Longer? - WebMD, 12/15/09 - "Perceived age, the researchers say, adjusted for chronological age and sex, also correlated with physical and cognitive functioning, as well as length of leukocyte telomeres - chromosome tips on DNA of people's white blood cells ... Shorter telomere length is associated with a “host of diseases related to aging and lifestyle factors and has been shown to be associated with mortality,”"
  • Scientists find molecular trigger that helps prevent aging and disease - Science Daily, 11/18/09 - "diabetes reduces activation of CBP, leading Dr. Mobbs to conclude that a high-calorie diet that leads to diabetes would have the opposite effect of dietary restriction and would accelerate aging"
  • Be Overweight And Live Longer, German Study Suggests - Science Daily, 10/16/09 - "overweight does not increase death rates, although obesity does increase them by 20%. As people grow older, obesity makes less and less difference ... For coronary heart disease, overweight increases risk by about 20% and obesity increases it by about 50%. On the other hand, a larger BMI is associated with a lower risk of bone and hip fracture"
  • 'Anti-Atkins' Low Protein Diet Extends Lifespan In Flies - Science Daily, 10/1/09 - Science Daily, 10/1/09 - "Flies fed an "anti-Atkins" low protein diet live longer because their mitochondria function better"
  • Drug Has Potential to Slow Aging - WebMD, 7/10/09 - "At first, the drug was not readily absorbed into the bloodstream of the mice, so a specialized feed was developed with an encapsulated, timed-release form of rapamycin"
  • Enzyme Important In Aging Identified - Science Daily, 7/10/09
  • Antibiotic Delayed Aging in Mice - NYTimes.com, 7/8/09 - "The effectiveness of rapamycin in extending the life of elderly mice was discovered by accident. The researchers found that the mice fed rapamycin were not getting the proper dose in their bloodstream. They reformulated the drug in the form of capsules that fed slow doses to the intestine, but by that time the mice were elderly. Nonetheless, life span increased by 14 percent in the females and 9 percent in the males"
  • Reduced Diet Thwarts Aging, Disease In Monkeys - Science Daily, 7/9/09 - "We observed that caloric restriction reduced the risk of developing an age-related disease by a factor of three and increased survival ... The incidence of cancerous tumors and cardiovascular disease in animals on a restricted diet was less than half that seen in animals permitted to eat freely. Remarkably, while diabetes or impaired glucose regulation is common in monkeys that can eat all they want, it has yet to be observed in any animal on a restricted diet"
  • Easter Island Compound Extends Lifespan Of Old Mice: 28 To 38 Percent Longer Life - Science Daily, 7/8/09
  • Biological 'Fountain Of Youth' Found In New World Bat Caves - Science Daily, 6/30/09
  • Study: Overweight People Live Longer - WebMD, 6/25/09 - "There is more evidence that people who are overweight tend to live longer than people who are underweight, normal weight, or obese ... Those classified as underweight were 73% more likely to die ... Those classified as extremely obese with BMI of 35 or greater were 36% more likely to die ... Those classified as obese with BMI 30-34.9 had about the same risk of death ... Those classified as overweight with BMI 25-29.9 were 17% less likely to die"
  • How To Confirm The Causes Of Iron Deficiency Anemia In Young Women - Science Daily, 6/23/09
  • Melatonin: The Fountain Of Youth? - Science Daily, 6/22/09 - "Melatonin can slow down the effects of aging. A team at laboratoire Arago in Banyuls sur Mer (CNRS / Université Pierre et Marie Curie) has found that a treatment based on melatonin can delay the first signs of aging in a small mammal ... studied the long-term effects of melatonin on the Greater White-toothed shrew, a small nocturnal insectivorous mammal. Under normal conditions, this animal shows the first signs of aging after reaching 12 months, mainly through the loss of circadian rhythm in its activities. By continuously administering melatonin, starting a little before 12 months, the appearance of these first signs was delayed by at least 3 months, which is a considerable period in relation to the lifespan of this shrew ... Melatonin is now known to play several beneficial roles. These include being an antioxidant, an anti-depressant, and helping to remediate sleep problems" - See melatonin at Amazon.com.
  • Multivitamins linked to younger ‘biological age’: Study - Nutra USA, 5/27/09 - "Compared to non-multivitamin users, the researchers noted that that telomeres were on average 5.1 per cent longer for daily multivitamin users ... Whereas the evidence is not sufficient to conclude that these 2 dietary antioxidants mediated the observed relation, the results are consistent with experimental findings that vitamins C and E protect telomeres in vitro" - [Abstract]
  • Multivitamin use and telomere length in women - Am J Clin Nutr. 2009 Jun;89(6):1857-63 - "After age and other potential confounders were adjusted for, multivitamin use was associated with longer telomeres. Compared with nonusers, the relative telomere length of leukocyte DNA was on average 5.1% longer among daily multivitamin users (P for trend = 0.002). In the analysis of micronutrients, higher intakes of vitamins C and E from foods were each associated with longer telomeres, even after adjustment for multivitamin use. Furthermore, intakes of both nutrients were associated with telomere length among women who did not take multivitamins"
  • Half A Glass Of Wine A Day May Boost Life Expectancy By Five Years - Science Daily, 4/29/09 - "light long term alcohol consumption of all types—up to 20 g a day— extended life by around two extra years compared with no alcohol at all. Extended life expectancy was slightly less for those who drank more than 20 g ... men who drank only wine, and less than half a glass of it a day, lived around 2.5 years longer than those who drank beer and spirits, and almost five years longer than those who drank no alcohol at all"
  • High IQ Linked To Reduced Risk Of Death - Science Daily, 3/13/09 - "a lower IQ was strongly associated with a higher risk of death from causes such as accidents, coronary heart disease and suicide ... the link between IQ and mortality could be partially attributed to the healthier behaviours displayed by those who score higher on IQ tests ... People with higher IQ test scores tend to be less likely to smoke or drink alcohol heavily, they eat better diets, and they are more physically active"
  • Not So Sweet: Over-consumption Of Sugar Linked To Aging - Science Daily, 3/9/09 - "We know that lifespan can be extended in animals by restricting calories such as sugar intake ...it's not sugar itself that is important in this process but the ability of cells to sense its presence ... the lifespan of yeast cells increased when glucose was decreased from their diet. They then asked whether the increase in lifespan was due to cells decreasing their ability to produce energy or to the decrease in signal to the cells by the glucose sensor ... cells unable to consume glucose as energy source are still sensitive to the pro-aging effects of glucose. Conversely, obliterating the sensor that measures the levels of glucose significantly increased lifespan"
  • Slowing Aging: Anti-aging Pathway Enhances Cell Stress Response - Science Daily, 2/19/09 - "The researchers discovered a new molecular relationship critical to keeping cells healthy across a long span of time: a protein called SIRT1, important for caloric restriction and lifespan and activated by resveratrol, regulates heat shock factor 1 (HSF1), keeping it active. HSF1 in turn senses the presence of damaged proteins in the cell and elevates the expression of molecular chaperones to keep a cell's proteins in a folded, functional state. Regulation of this pathway has a direct beneficial effect to cells ... decrease in SIRT1 may help explain why protein misfolding diseases, such as Alzheimer's, Parkinson's, Huntington's and adult-onset diabetes, are diseases of aging" - See resveratrol products at Amazon.com.
  • Eating Less May Not Extend Human Life: Caloric Restriction May Benefit Only Obese Mice - Science Daily, 1/26/09 - "For lean mice – and possibly for lean humans, the authors of a new study predict – the anti-aging strategy known as caloric restriction may be a pointless, frustrating and even dangerous exercise ... Today there are a lot of very healthy people who look like skeletons because they bought into this ... Contrary to what is widely believed, caloric restriction does not extend (the) life span of all strains of mice ... caloric restriction begun in older mice – both in DBA and leaner C57 individuals – actually shortened life span"
  • Old Gastrointestinal Drug Slows Aging, Researchers Say - Science Daily, 1/6/08 - "Recent animal studies have shown that clioquinol – an 80-year old drug once used to treat diarrhea and other gastrointestinal disorders – can reverse the progression of Alzheimer's, Parkinson's and Huntington's diseases ... clioquinol acts directly on a protein called CLK-1, often informally called "clock-1," and might slow down the aging process ... Because clock-1 affects longevity in invertebrates and mice, and because we're talking about three age-dependent neurodegenerative diseases, we hypothesize that clioquinol affects them by slowing down the rate of aging ... clioquinol was withdrawn from the market after being blamed for a devastating outbreak of subacute myelo-optic neuropathy (SMON) in Japan in the 1960s. However, because no rigorous scientific study was conducted at the time, and because clioquinol was used safely by millions before and after the Japanese outbreak, some researchers think its connection to SMON has yet to be proven" - I Googled clioquinol and I don't think it's available anywhere.
  • Both Major Theories About Human Cellular Aging Supported By New Research - Science Daily, 12/30/08 - "old age is the final stage of a developmental program AND the result of a lifelong accumulation of unrepaired cellular and molecular damage ... When fatty acids build up, yeast cells explode from within, scattering their contents and spreading inflammation to neighboring cells ... In addition to cell death, the accumulation of fatty acids sets off chemical reactions that ultimately produce a lipid called diacylglycerol, which impairs many of the yeast's stress response-related defenses ... Low-calorie diets, which have been shown to increase lifespan and delay age-related disorders in nonhuman primates and other organisms, altered the way fats were processed in the yeast cells"
  • Scientists Find a Possible Cause of Aging - NYTimes.com, 11/26/08 - "A new insight into the reason for aging has been gained by scientists trying to understand how resveratrol, a minor ingredient of red wine, improves the health and lifespan of laboratory mice. They believe that the integrity of chromosomes is compromised as people age, and that resveratrol works by activating a protein known as sirtuin that restores the chromosomes to health ... Dr. Sinclair has been taking large daily doses of resveratrol since he and others discovered five years ago that it activated sirtuin. “I’m still taking it and I feel great,” he said, “but it’s too early to say if I’m young for my age."" - See resveratrol products at Amazon.com.
  • A Healthy Lifestyle Halves The Risk Of Premature Death In Women - Science Daily, 9/16/08 - "Over half of deaths in women from chronic diseases such as cancer and heart disease could be avoided if they never smoke, keep their weight in check, take exercise and eat a healthy diet low in red meat and trans-fats"
  • Clean living 'slows cell ageing' - BBC News, 9/15/08 - "Among 24 men asked to adopt healthy lifestyle changes for a US study in The Lancet Oncology, levels of telomerase increased by 29% on average ... Telomerase repairs and lengthens telomeres, which cap and protect the ends of chromosomes housing DNA ... These consisted of a diet high in fruit and vegetables, supplements of vitamins and fish oils, an exercise regimen and classes in stress management, relaxation techniques and breathing exercises"
  • Low Vitamin D Levels Pose Large Threat To Health; Overall 26 Percent Increased Risk Of Death - Science Daily, 8/12/08 - "This translates overall to an estimated 26 percent increased risk of any death, though the number of deaths from heart disease alone was not large enough to meet scientific criteria to resolve that it was due to low vitamin D levels ... Previous results from the same nationwide survey showed that 41 percent of men and 53 percent of women are technically deficient in the nutrient, with vitamin D levels below 28 nanograms per milliliter" - See vitamin D at Amazon.com.
  • Running Slows the Effects of Aging - WebMD, 8/11/08 - "Older runners have fewer disabilities, remain more active as they get into their 70s and 80s, and are half as likely as non-runners to die early deaths, the study shows ... If you had to pick one thing to make people healthier as they age, it would be aerobic exercise ... The researchers used national death records to learn which participants died and why. Nineteen years into the study, 34% of the non-runners had died, compared with only 15% of the runners" - [Science Daily]
  • Low Level of Vitamin D Ups Death Risk - WebMD, 8/11/08 - "Over an average follow-up period of about nine years, 1,806 participants died. The researchers found a 26% increased risk of death from any cause for the quartile of participants with the lowest vitamin D levels compared to those with the highest levels" - See vitamin D at Amazon.com.
  • Resveratrol, Found In Red Wine, Wards Off Effects Of Age On Heart, Bones, Eyes And Muscle - Science Daily, 7/3/08 - "This study, conducted and supported in part by the National Institute on Aging (NIA), part of the National Institutes of Health, is a follow-up to 2006 findings that resveratrol improves health and longevity of overweight, aged mice. The report confirms previous results suggesting the compound, found naturally in foods like grapes and nuts, may mimic, in mice, some of the effects of dietary or calorie restriction, the most effective and reproducible way found to date to alleviate age-associated disease in mammals" - See resveratrol products at Amazon.com.
  • Substance In Red Wine, Resveratrol, Found To Keep Hearts Young - Science Daily, 6/4/08 - "Resveratrol is active in much lower doses than previously thought and mimics a significant fraction of the profile of caloric restriction at the gene expression level ... In animals on a restricted diet, 90 percent of those heart genes experienced altered gene expression profiles, while low doses of resveratrol thwarted age-related change in 92 percent. The new findings, say the study's authors, were associated with prevention of the decline in heart function associated with aging" - See resveratrol products at Amazon.com.
  • Low-dose resveratrol may slow ageing: for mice at least - Nutra USA, 6/4/08 - "animals in the calorie-restriction and low-dose resveratrol groups had altered gene expression profiles in 90 and 92 per cent, respectively, in the heart ... In short, a glass of wine or food or supplements that contain even small doses of resveratrol are likely to represent "a robust intervention in the retardation of cardiac ageing,"" - See resveratrol products at Amazon.com.
  • Red wine may protect heart from aging’s toll - MSNBC - 6/3/08 - "Resveratrol at low doses can retard some aspects of the aging process, including heart aging, and it may do so by mimicking some of the effects of caloric restriction, which is known to retard aging in several tissues and extend life span" - See resveratrol products at Amazon.com.
  • Dietary lipoic acid supplementation can mimic or block the effect of dietary restriction on life span -Mech Ageing Dev. 2008 Apr 22;129(6):341-348 - "Ad libitum feeding a diet supplemented with lipoic acid can therefore act as mimetic of DR to extend survival" - See alpha lipoic acid at Amazon.com.
  • Lifelong prebiotic supplements may enhance survival: rat study - Nutra USA, 4/24/08 - "In terms of survival, at 18 months of age, all the animals in the prebiotic group were still alive, compared to 76 per cent in the control group. After 24 months, 81 per cent of the rats in the prebiotic group were alive, compared to only 52 per cent of controls" - [Abstract] - See inulin products at iHerb.
  • Effects of lifelong intervention with an oligofructose-enriched inulin in rats on general health and lifespan - Br J Nutr. 2008 Apr 11;:1-8 - "a diet with 10 % of an oligofructose-enriched inulin (Synergy1) ... During the whole intervention period, male rats receiving Synergy1 (SYN1-M) displayed lower body weight, cholesterol and plasma triacylglycerolaemia compared with the controls (Cont-M). The survival rate at 24 months of age of SYN1-M rats was 35.3 % greater than that of Cont-M rats. In female rats, the Synergy1 supplementation (SYN1-F) group also reduced body weight, cholesterol and triacylglycerolaemia levels, but results were less consistent over the experiment. The survival rate at 24 months of age in SYN1-F rats was 33.3 % greater compared with that of the control (Cont-F) group. To conclude, lifelong intervention with Synergy1 improved biological markers during ageing and survival rate (lifespan) of rats" - See inulin products at iHerb.
  • Serum Dehydroepiandrosterone Sulfate Levels Predict Longevity in Men: 27-Year Follow-Up Study in a Community-Based Cohort (Tanushimaru Study) - J Am Geriatr Soc. 2008 Apr 18 - "in men after adjustments for age, systolic blood pressure, and fasting plasma glucose showed significantly (log-rank stat =10.6; P<.001) greater longevity in the highest group (200 mug/dL) than in the moderate (130-199 mug/dL) or lowest groups (129 mug/dL)" - See DHEA at Amazon.com.
  • Lipoic acid significantly restores, in rats, the age-related decline in vasomotion - Br J Pharmacol. 2008 Feb 25 - "In old animals, endothelium-dependent relaxation in aortic rings was decreased, GSH levels and its redox state in aortic endothelia were over 30% lower and nSMase activity and endothelial ceramide levels were three-fold increased, relative to young (2-4 mo) rats. LA treatment of old animals improved relaxation in aortic rings, reversed the changes in endothelial GSH, in nSMase activities and in ceramide levels. Similar effects on GSH levels and nSMase activity in old rats were also induced by treatment with GSH monoethylester. Activation (by phosphorylation) of eNOS was decreased by about 50% in old rats and this age-related decrease was partially reversed by LA treatment" - See alpha lipoic acid at Amazon.com.
  • Sedentary Lifestyles Associated With Accelerated Aging Process - Science Daily, 1/28/08 - "Telomere length decreased with age, with an average loss of 21 nucleotides (structural units) per year. Men and women who were less physically active in their leisure time had shorter leukocyte telomeres than those who were more active. ... "The mean difference in leukocyte telomere length between the most active [who performed an average of 199 minutes of physical activity per week] and least active [16 minutes of physical activity per week] subjects was 200 nucleotides, which means that the most active subjects had telomeres the same length as sedentary individuals up to 10 years younger, on average."" - I'm must be in fat city on this one.  I must have averaged 60 minutes per day since I've been 18 which comes to 420 minutes per week.  Maybe that's the main reason people claim I look young. Plus I've always taken vitamin D which helps with telomere length also. - Ben
  • Sustained Tubulo-interstitial Protection in SHRs by Transient Losartan Treatment: An Effect of Decelerated Aging? - Am J Hypertens. 2008 Jan 10 - "Transient losartan treatment reduces cell-turnover not only acutely but also for a prolonged period after drug withdrawal. This results in the long-term in reduced aging and attenuated tubulo-interstitial damage, suggesting there exists a modulating effect of angiotensin II (ANGII)-antagonism on long-term cell turnover" - Note:  Losartan is an ARB.  I would think that telmisartan (also and ARB and my recommendation for hypertension) would give the same effect.
  • Four Health Behaviors Can Add 14 Extra Years Of Life - Science Daily, 1/8/08 - "People who adopt four healthy behaviours -- not smoking; taking exercise; moderate alcohol intake; and eating five servings of fruit and vegetables a day -- live on average an additional fourteen years of life compared with people who adopt none of these behaviours"
  • Herbal Extract Found To Increase Lifespan - Science Daily, 12/5/07 - "Flies that ate a diet rich with Rhodiola rosea, an herbal supplement long used for its purported stress-relief effects, lived on an average of 10 percent longer than fly groups that didn’t eat the herb ... Although this study does not present clinical evidence that Rhodiola can extend human life, the finding that it does extend the lifespan of a model organism, combined with its known health benefits in humans, make this herb a promising candidate for further anti-aging research ... Rhodiola rosea ... has been used by Scandinavians and Russians for centuries for its anti-stress qualities ... patients taking a Rhodiola extract called SHR-5 reported fewer symptoms of depression than did those who took a placebo" - See Rhodiola rosea at Amazon.com.
  • Fit Beats Fat for a Longer Life - WebMD, 12/4/07 - "Fitness was found to be a strong predictor of longevity in the study, which involved adults ages 60 and older, while obesity had little influence on death risk"
  • Could Hydrogen Sulfide Hold The Key To A Long Life? - Science Daily, 12/4/07
  • Fat Hormone May Contribute To Longevity - Science Daily, 11/21/07 - "long-lived Snell dwarf mice burn less glucose and more fatty acids during periods of fasting, and as a result produce fewer free radicals ... The key to this switch may be adiponectin, a hormone produced by fat cells that helps lower glucose production and stimulates cells to use fat for energy instead. The researchers found that Snell mice had three times as much adiponectin in their blood as control mice" - See my adiponectin page for ways to increase it.  Something that was also in today's abstracts was pioglitazone, which increased adiponectin 156%.
  • Drug Commonly Used To Treat Bipolar Disorder Dramatically Increases Lifespan In Worms - Science Daily, 10/30/07 - "Nematode worms treated with lithium show a 46 percent increase in lifespan, raising the tantalizing question of whether humans taking the mood affecting drug are also taking an anti-aging medication" - See lithium products at iHerb.
  • Can Fat Be Fit?  -- Scientific American, 9/07
  • Avoiding Sweets May Spell A Longer Life, Study In Worms Suggests - Science Daily, 10/2/07 - "A new study in Cell Metabolism reveals that worms live to an older age when they are unable to process the simple sugar glucose"
  • Loneliness Can Speed Aging - WebMD, 8/20/07 - "lonely people live in a heightened sense of arousal, which could have long-term effects on heart disease and other health problems"
  • Vitamin Extends Life In Yeast, Scientists Find - Science Daily, 5/3/07 - "providing a newly discovered vitamin activates the yeast anti-aging gene product Sir2, which resembles sirtuins found in humans. The new work builds on Brenner's prior discovery of the vitamin, termed NR (nicotinamide riboside), a natural product found in milk. Like the B3 vitamin, niacin, NR is a precursor to a versatile cellular factor that is vital for all life"
  • New Clues on What Causes Aging - WebMD, 12/21/06
  • Cool Mice Live Longer - WebMD, 11/2/06 - "the cool mice live significantly longer than normal mice. Females lived about 20% longer than normal. Males lived about 12% longer"
  • Cell Mutations That Lead To Apoptosis May Contribute To Aging In Mammals - Science Daily, 7/15/05 - "mutations in the mitochondria caused by obesity and lack of exercise -- not oxidative stress from free radicals -- may be a key factor in the aging process"
  • Obesity, Smoking Linked to Faster Aging - WebMD, 6/13/05 - "Telomeres are the tips of the chromosomes, which contain DNA. They gradually shorten over a lifetime ... The difference in telomere length between being lean and being obese corresponds to 8.8 years of aging ... Obesity and smoking are important risk factors for many age-related diseases. Both are states of heightened oxidative stress … and inflammation"
  • Anti-aging Enzyme's Secrets Revealed - Science Daily, 4/1/05
  • Mountain Life Spells Longer Life - Science Daily, 3/29/05 - "as blood lipids and blood pressure were higher among the mountain residents, other 'protective' factors must be at play ... living at moderately high altitude produces long term physiological changes in the body to enable it to cope with lower levels of oxygen, and that this, combined with the exertion required to walk uphill regularly on rugged terrain, could give the heart a better work-out"
  • Live long, the Okinawan way - Maui News, 1/14/05
  • System That Regulates Blood Pressure May Also Affect Aging - Science Daily, 11/22/04
  • Social & Environmental Factors Play Important Role In How People Age, Two Studies Find - Science Daily, 9/14/04 - "those who scored high on positive affect were significantly less likely to become frail. Each unit increase in baseline positive affect score was associated with a three percent decreased risk of frailty"
  • Healthy Aging Requires Healthy Attitudes - WebMD, 9/13/04 - "the patients who exhibited more positive emotions were significantly less likely to become frail. For example, every point increase in a senior's positive effect score at the start of the study was associated with a 3% decreased risk of frailty"
  • Why do the Japanese live so long? - Guardian Unlimited, 6/10/04 - "People in Japan eat a third fewer calories than the typical North American. What they eat is also important: more seafood and, hence, healthy fish oils ... the Japanese are less sedentary than westerners, and Japan a less stressed society"
  • Insulin Plays Central Role In Aging, Brown Scientists Discover - Science Daily, 6/4/04 - "insulin regulates its own production and that it directly regulates tissue aging. The principle: Keep insulin levels low and cells are stronger, staving off infection and age-related diseases such as cancer, dementia and stroke"
  • Insulin plays central role in ageing, explains benefits of calorie reduction - Nutra USA, 6/3/04 - "if insulin levels remain low, cells are stronger and can ward off infection and age-related diseases such as cancer, dementia and stroke"
  • Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body - Nature. 2004 Jun 3;429(6991):562-6
  • DNA damage could be a start to aging, study suggests - USA Today, 5/26/04 - "the results are also consistent with the theory that so-called "free radicals" play a role in aging"
  • Social Connections Build Healthier Lives - WebMD, 4/30/04 - "the prevalence of ill health was highest among those who rarely or never attended church and lowest among those that attended church regularly. Members of civic groups or those who volunteered regularly were also more likely to be completely healthy and less likely to report complete ill health than others"
  • How to Age Well - WebMD, 10/27/03 - "What made them different than the other half? One thing stands out. Those who stayed healthy had perfectly healthy hearts. They didn't even have "subclinical" heart problems, the ones so minor they can only be detected by testing ... For men, having subclinical heart disease was like being 6.5 years older. For women, it was like being 5.5 years older ... refrain from smoking, lower their blood lipids, watch blood pressure, and avoid obesity through diet and exercise"
  • Longevity May Run in Your Blood - WebMD, 10/14/03 - "the HDL and LDL particle sizes were significantly larger in the exceptionally old adults compared with both control groups, regardless of their cholesterol levels ... this trait was also associated with lower rates of high blood pressure, heart disease, and other health problems that account for a large number of deaths among the elderly"
  • Does Growing Old Cause Cancer? - WebMD, 9/25/03
  • The Serious Search for an Anti-Aging Pill - Scientific America, 8/03 - "Regrettably, however, 2DG has a fatal flaw preventing it from being the "magic pill" we were hoping for. Though safe at certain low levels, it apparently becomes toxic for some animals when the amount delivered is raised just a bit or given over long periods ... Treatment with antidiabetic medications that enhance cellular sensitivity to insulin might be helpful as well, as long as the amounts given do not cause blood glucose levels to fall too low ... Drugs that replicate only selected effects of caloric restriction could have a role to play as well. In theory, antioxidant vitamins might fit that bill"
  • Children of Centenarians Have Delays in Age-Related Diseases - Doctor's Guide, 5/20/03 - "Fewer offspring of centenarians took prescription medicines, and they have lower weight and body mass compared to controls"
  • Reaching 100 Is Largely a Matter of Genes - WebMD, 4/8/03
  • Survival to 90 Years Linked to Low Weight in Young Adulthood and Exercise - Doctor's Guide, 4/8/03 - "baseline height and weight were not associated with mortality. However, a higher weight at age 21 was associated with increased odds of dying before reaching 90 years (OR=1.04 per 5 lb increase, P 0.0001). Those who exercised were 24-31% less likely to die by the age of 90 (OR=0.76, P 0.0001 for less than 1 hour per day, OR=0.69, P 0.0001 for 1 hour or more per day). Similarly, being in the mid tertile of BMI at baseline (22-24 for men, 20-23 for women) was associated with decreased odds of dying before age 90 (OR=0.70, P 0.0001)"
  • The Fight for the Fountain of Youth - WebMD, 2/10/03
  • A Prescription for Longevity - Physician's Weekly, 1/27/03 - "Okinawans have no genetic predisposition to longevity but rather benefit from the consumption of vegetables, tofu, seaweed; the pursuit of rigorous activity; and a low stress lifestyle. The authors claim if Americans could adopt the habits of Okinawans, "80 percent of the nation¹s coronary care units, one-third of the cancer wards, and a lot of nursing homes would be shut down.""
  • Less Body Fat = Longer Life - WebMD, 1/23/03 - "Of the 250 mice in Bluher's study, half were specially bred to lack a response to the hormone insulin specifically in their fat cells -- he calls them "FIRKO mice." These mice were unable to store body fat. The normal mice were able to gain weight and body fat as usual ... The normal mice lived normal mouse-length lives -- 30 months. But at 30 months, 80% of the FIRKO mice were still alive ... His study suggests that increased metabolism is the secret to the FIRKO mouse's leanness and longevity"
  • Longevity Runs In Families: Study Looks At Genetics, Environment - Intelihealth, 11/25/02 - "Female children of the centenarians weighed, on average, 146 pounds, while the female children of the control group weighed 158, on average. The male children of the centenarians weighed 184, on average, while the male children in the control group had an average weight of 202"
  • Present From Mom and Dad: A Longer Life - WebMD, 11/18/02
  • Generous spirit may yield generous life span - USA Today, 11/14/02
  • Scientists Extend Life Span - WebMD, 10/25/02
  • Supportive Family Helps Successful Aging - WebMD, 5/24/02
  • Mountain Life May Make Women Age Faster - WebMD, 4/24/02 - "New research shows that life at high altitudes can speed the aging process for a woman by affecting her hormones ... In fact, by age 70, the levels of DHEA in the women who lived in the mountains were only about 40% of those in the comparison group"
  • Gene Scientists Find Clues To Why We Age - Intelihealth, 4/12/02
  • Boomers Search For Relief From Aging - Intelihealth, 4/10/02 - "But I feel like I'm launching into one of the most exciting periods of my life. And I want my quality of life to be good, so that I can continue to do all the things I enjoy" - That's the whole point about the information on my web site.
  • Warning Against 'Anti-Aging' Medicine - WebMD, 3/6/02 - Articles like this burn me up. Most people will be six feet under before those studies come in. I feel you need to go with the best scientific information available at the time. Also, Dr. Smith’s comment that "There is as yet no convincing evidence that administration of any specific compound, natural or artificial, can globally slow aging in people, or even in mice or rats" is absolutely false. Take for example the study published in the 2/19/02 Proceedings of the National Academy of Sciences on alpha lipoic acid and acetyl-l-carnitine or the studies with deprenyl and rats? I could go on and on. Some doctors think that the three credits in nutrition they got back in 1985 from text books written in the 70’s allow them to make bold lies without even reading the research.  LEF has references for their articles.  I guess if your a doctor, you can make bold statements like Dr. Smith's without references.  I agree with the following statement by Dr. Klatz: "To become a physician, you have to take the Hippocratic Oath, in which you swear to "do no harm." But there are many ways to interpret that phrase. As all Catholics are aware, there are sins of omission and sins of commission. Cutting off the wrong leg of a diabetic or operating on the wrong side of the head in a patient with a brain tumor as happened recently in two New York hospitals is clearly doing harm. But what about not keeping abreast of the latest diagnostic treatment or advances? Or failing to inform a patient of lifestyle changes or options that could drastically lower risk of disease? Or taking a authoritarian, I-know-better-than-you attitude that effectively cuts off all questions about alternative measures and treatments? All these "sins of omission" may end up doing you harm in terms of accelerated aging, disease, and death." - Ben
  • Cancer-Fighting Protein May Play Role In Aging, Mouse Study Suggests - Intelihealth, 1/3/02
  • Optimism May Lower Heart Disease Risk In Older Men - Intelihealth, 12/13/01 - "The researchers found that the most highly optimistic men were less likely to develop heart disease than the most pessimistic men. In fact, each increase in the level of optimism was associated with an approximately 25% decreased risk of chest pain and heart disease"
  • Secrets to Aging Gracefully - WebMD, 12/10/01 - "the happiest respondents had minor physical disabilities. They had regular social activities, could still think and reason well, and had an overall feeling of well-being -- and those were important to staying happy. In many cases, they were able to keep up socially because they had spent a lot of time cultivating relationships with friends and family when they were younger, and such investments in their time paid big dividends in terms of avoiding depression and staying vital later in life"
  • Vegetarian diet on solid ground, experts say - USA Today, 12/7/01 - "McDougall points to a recent study in the Archives of Internal Medicine that looked at Seventh-Day Adventists in California, a group made up mostly of vegetarians. The 12-year of study of 34,192 people found that on average, group members lived 10 years longer than the general population ... Vegetarians have a 40% less risk of cancer and much less risk of heart disease, diabetes, hypertension, kidney disease and other problems that are common among meat eaters"
  • Honing In on the Fountain of Youth - WebMD, 9/25/01
  • Pitter-Patter Of Paws Is Time-Tested Remedy - Intelihealth, 7/24/01 - article about how pets help you "live longer, heal faster, lower blood pressure and cholesterol and have a better chance of surviving a heart attack"
  • Add a Decade to Your Life - WebMD, 7/20/01 - "Compared with other Californians, we found that Adventist men lived about 7.3 years longer and women lived about 4.4 years longer," Fraser tells WebMD. "And for vegetarian Adventists who eat meat [no more than] once a month -- which accounts for about 30% Adventists -- the differences in life expectancy swell to 9.5 years in men and 6.1 years in women. Those are pretty big numbers."
  • The Future is Now: You Can Control How Well You Age, Depression, Education Key Factors - WebMD, 6/1/01 - "However, if the seven controllable factors are in check, the only uncontrollable factor that is likely to wreak havoc with your older years is depression"
  • Happy Thoughts May Prolong Life - Intelihealth, 5/8/01 - "a 15-year study of aging and Alzheimer's disease in nuns suggests a positive emotional state at an early age may help ward off disease and even prolong life"
  • Bad Health Habits Would Be Taxing Under New Scheme - WebMD, 4/13/01 - "nearly three-quarters of all disease in America results from an "unhealthy lifestyle.""
  • Here's to a Long Life! Hormone Pathway That Controls Aging Discovered, Findings Suggest Low-Cal Diet May Extend Lifespan - WebMD, 4/5/01
  • Youth for Sale, Antiaging Patients Looking, Feeling Good -- But Long-Term Safety Unknown - WebMD, 10/13/00
  • Experiments Extend Life Of Nematode - Intelihealth, 9/1/00
  • Gene Study May Explain Why Low-Calorie Diet Slows Aging - WebMD, 6/28/00
  • Good habits now key to living longer, healthier life - CNN, 5/29/00
  • Workaholism Can Cause Mental, Physical Problems - WebMD, 5/5/00
  • Cloned Cows Cells Stay Young - Intelihealth, 4/28/00
  • Science takes cellular approach to explore aging process - CNN, 1/4/00
  • Staying Young Forever, Putting new research findings into practice - Life Extension Foundation, 12/99
  • Good Health Habits Can Extend Life By About A Decade, Study Shows - Intelihealth, 11/30/99
  • Herbs riding high, especially healthy ones - CNN, 11/3/99
  • Anti-aging nutrition secrets - CNN, 8/4/99
  • FDA Joins Battle Against Aging - Doctor's Guide, 2/27/97
  QualityCounts.com Anti-aging Newsletter
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