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Home > Health Conditions > Radiation Therapy

Radiation Therapy

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  • Pomegranate Intake Protects Against Genomic Instability Induced by Medical X-rays In Vivo in Mice - Nutr Cancer. 2016 Nov-Dec;68(8):1349-1356 - "Ionizing radiation (IR) is a well-documented human carcinogen. The increased use of IR in medical procedures has doubled the annual radiation dose and may increase cancer risk. Genomic instability is an intermediate lesion in IR-induced cancer. We examined whether pomegranate extract (PE) suppresses genomic instability induced by x-rays ... glutathione (GSH) ... Thus, ingestion of pomegranate polyphenols is associated with inhibition of x-ray-induced genomic instability and elevated GSH, which may reduce cancer risk" - See pomegranate extract at Amazon.com.
  • Effect of Oral Silymarin Administration on Prevention of Radiotherapy Induced Mucositis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial - Phytother Res. 2016 Aug 23 - "Mucositis is a frequent severe complication of radiation therapy in patient with head and neck cancer ... oral silymarin 420 mg daily in three divided doses starting at the first day of radiotherapy for 6 weeks, on oral mucositis occurrence was assessed ... The median World Health Organization and National Cancer Institute Common Terminology Criteria scores were significantly lower in silymarin group at the end of the first to sixth week (p < 0.05). The scores increased significantly in both placebo and silymarin groups during radiotherapy, but there was a delay for mucositis development and progression in silymarin group. Prophylactic administration of conventional form of silymarin tablets could significantly reduce the severity of radiotherapy induced mucositis and delay its occurrence in patients with head and neck cancer" - See silymarin at Amazon.com.
  • Modulation of Radiation-Induced Alterations in Oxidative Stress and Cytokine Expression in Lung Tissue by Panax Ginseng Extract - Phytother Res. 2014 Sep 15 - "We investigated the modulating effect of Panax ginseng extract (PGE) on radiation-induced lung injury (RILI) ... A high pretreatment dose of PGE may be a useful pharmacological approach for protection against RILI" - See ginseng at Amazon.com.
  • Antioxidant supplementation has a positive effect on oxidative stress and hematological toxicity during oncology treatment in cervical cancer patients - Support Care Cancer. 2012 Dec 14 - "Hematological toxicity and oxidative stress are common in cancer patients ... Randomized, single-blinded controlled trial in women with cervical cancer treated with radiotherapy and chemotherapy with cisplatin. Subjects were randomly assigned to receive antioxidant supplement or placebo supplement ... At the end of the oncology treatment, hemoglobin levels were maintained, and global QoL was better only in the supplemented group ... Antioxidant supplementation in patients treated with chemotherapy and radiotherapy apparently decreased oxidative stress, maintained hemoglobin levels, and improved QoL" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Probiotic protects intestine from radiation injury - Science Daily, 11/16/11 - "the therapy can kill both cancer cells and healthy ones, leading to severe bouts of diarrhea if the lining of the intestine gets damaged ... For many patients, this means radiation therapy must be discontinued, or the radiation dose reduced, while the intestine heals ... Probiotics may provide a way to protect the lining of the small intestine from some of that damage ... the probiotic bacteria Lactobacillus rhamnosus GG (LGG), among other Lactobacillus probiotic strains, protected the lining of the small intestine in mice receiving radiation ... the probiotic was effective only if given to mice before radiation exposure ... The bacteria we use is similar to what's found in yogurt or in commercially available probiotics ... So theoretically, there shouldn't be risk associated with this preventative treatment strategy any more than there would be in a patient with abdominal cancer eating yogurt" - See probiotics at Amazon.com.
  • Protective Effect of Lycopene against Radiation-induced Hepatic Toxicity in Rats - J Int Med Res. 2011;39(4):1239-52 - "Lycopene supplementation significantly reduced radiotherapy-induced oxidative liver injury" - See lycopene at Amazon.com.
  • Green Tea Extract (Epigallocatechin-3-Gallate) Reduces Efficacy of Radiotherapy on Prostate Cancer Cells - Urology. 2011 Jun 13 - "Radiotherapy is effective in inducing apoptosis in DU145 cells, but its effect was significantly reduced in the presence of EGCG, and this was associated with an increase in the induction of manganese superoxide dismutase"
  • Protective Role of Tea Polyphenols in Combination against Radiation-induced Haematopoietic and Biochemical Alterations in Mice - Phytother Res. 2011 Mar 31 - "The purpose of this study was to investigate the radioprotective effects of tea polyphenols (TPs) in various combinations against radiation-induced damage in mice. Mice were divided into different groups: non-irradiated control, irradiated control, amifostine (43.6 mg/kg, i.v. 30 min before irradiation; positive control) and various combinations of tea polyphenols in different doses. The radioprotective effect on the haematopoietic system, serum cytokines and endogenous antioxidant enzymes were studied. TP50, containing approximately 50% of (-)-epigallochatechin-3-gallate in addition to other catechins, showed the greatest radioprotective effect against radiation-induced changes in haematological parameters (red blood cell count, white blood cell count and haemoglobin), and maintained the spleen and thymus indices unchanged (spleen or thymus weight/body weight × 1000). Tea polyphenols also significantly decreased radiation-induced lipid peroxidation (malondialdehyde levels), elevated endogenous antioxidant enzymes (superoxide dismutase) and reduced the serum cytokines which were elevated in radiation-induced toxicity. This evidence shows the potential of tea polyphenols, particularly in the combination found in TP50, as radioprotectors in mice, especially regarding recovery of the haematopoietic system, antioxidant potential activity and reduction of inflammatory cytokines" - See green tea extract at Amazon.com.
  • Soy increases radiation's ability to kill lung cancer cells, study shows - Science Daily, 4/1/11 - "These natural soy isoflavones can sensitize cancer cells to the effects of radiotherapy, by inhibiting survival mechanisms which cancer cells activate to protect themselves ... At the same time, soy isoflavones can also act as antioxidants in normal tissues, which protect them against unintended damage from the radiotherapy ... soy isoflavones increase killing of cancer cells by radiation via blocking DNA repair mechanisms, which are turned on by the cancer cells to survive the damage caused by radiation ... Researchers used a formulation consisting of the three main isoflavones found in soybeans, including genistein, daidzein and glycitein ... Previously, researchers had found that pure genistein demonstrated antitumor activity in human NSCLC cell lines and enhanced the effects of EGFR-tyrosine kinase inhibitors. This study showed that the soy mixture had an even greater antitumor effect than pure genistein" - See soy isoflavones at Amazon.com.
  • Antioxidant formula prior to radiation exposure may prevent DNA injury, trial suggests - Science Daily, 3/29/11 - "In what the researchers say is the first clinical trial of its kind, as much as a 50 percent reduction in DNA injury was observed after administering the formula prior to CT scans"
  • Vitamin supplement use during breast cancer treatment and survival: a prospective cohort study - Cancer Epidemiol Biomarkers Prev. 2010 Dec 21 - "Antioxidants may protect normal cells from the oxidative damage that occurs during radiotherapy and certain chemotherapy regimens, however, the same mechanism could protect tumor cells and potentially reduce effectiveness of cancer treatments ... Vitamin use shortly after breast cancer diagnosis was associated with reduced mortality and recurrence risk, adjusted for multiple lifestyle factors, sociodemographics, and known clinical prognostic factors. Women who used antioxidants (vitamin E, vitamin C, multivitamins) had 18% reduced mortality risk (hazard ratio (HR) = 0.82, 95% confidence interval (CI): 0.65-1.02) and 22% reduced recurrence risk (HR = 0.78, 95% CI: 0.63-0.95). The inverse association was found regardless of whether vitamin use was concurrent or non-concurrent with chemotherapy, but was only present among patients who did not receive radiotherapy"
  • High dietary niacin intake is associated with decreased chromosome translocation frequency in airline pilots - Br J Nutr. 2010 Oct 8:1-9 - "Experimental studies suggest that B vitamins such as niacin, folate, riboflavin, vitamin B6 and vitamin B12 may protect against DNA damage induced by ionising radiation (IR) ... We observed a significant inverse association between translocation frequency and dietary intake of niacin (P = 0.02): adjusted rate ratio for subjects in the highest tertile compared with the lowest tertile was 0.58 (95 % CI 0.40, 0.83). Translocation frequency was not associated with total niacin intake from food and supplements as well as dietary or total intake of folate, riboflavin or vitamin B6 or B12. However, the adjusted rate ratios were significant for subjects with ≥ median compared with < median intake of whole grains (P = 0.03) and red and processed meat (P = 0.01): 0.69 (95 % CI 0.50, 0.96) and 1.56 (95 % CI 1.13, 2.16), respectively. Our data suggest that a high intake of niacin from food or a diet high in whole grains but low in red and processed meat may protect against cumulative DNA damage in IR-exposed persons"
    • Airplane Radiation Exposure Protection - "During a cross country flight from NY to LA you are subjected to more radiation from the plane then you are during a chest X-ray" - Note:.  Think about it, if a pilot were to average two round trips per week (very reasonable), that's 4 chest x-rays per week or 208 chest x-rays per year.
  • Soy isoflavones in conjunction with radiation therapy in patients with prostate cancer - Nutr Cancer. 2010 Oct;62(7):996-1000 - "Soy isoflavones sensitize prostate cancer cells to radiation therapy by inhibiting cell survival pathways activated by radiation. At the same time, soy isoflavones have significant antioxidant and anti-inflammatory activity, which may help prevent the side effects of radiation ... Adverse effects of radiation therapy on bladder, bowel, and sexual function were assessed by a self-administered quality of life questionnaire at 3 and 6 mo. Only 26 and 27 patients returned completed questionnaires at 3 and 6 mo, respectively. At each time point, urinary, bowel, and sexual adverse symptoms induced by radiation therapy were decreased in the soy isoflavone group compared to placebo group. At 3 mo, soy-treated patients had less urinary incontinence, less urgency, and better erectile function as compared to the placebo group. At 6 mo, the symptoms in soy-treated patients were further improved as compared to the placebo group. These patients had less dripping/leakage of urine (7.7% in Group 1 vs. 28.4% in Group 2), less rectal cramping/diarrhea (7.7% vs. 21.4%), and less pain with bowel movements (0% vs. 14.8%) than placebo-treated patients. There was also a higher overall ability to have erections (77% vs. 57.1%). The results suggest that soy isoflavones taken in conjunction with radiation therapy could reduce the urinary, intestinal, and sexual adverse effects in patients with prostate cancer" - See soy isoflavones at Amazon.com.
  • Lycopene in the prevention of gastrointestinal toxicity of radiotherapy - Nutr Cancer. 2009 Nov;61(6):784-8 - "The rats receiving RT only had significantly higher weight loss rate compared to the lycopene plus RT group (P = 0.001). Plasma TBARS levels after RT were also significantly higher in the RT only group compared to lycopene plus RT group (P = 0.001). In conclusion, lycopene supplementation significantly reduced the weight loss and prevented oxidative stress in rats treated with abdominopelvic radiation" - See lycopene at Amazon.com.
  • Herbal Tonic For Radiotherapy? Gingko Biloba Tree May Protect Cells From Radiation Damage - Science Daily, 10/26/09 - "They found that there was a significant increase in apoptosis in the untreated cells compared with those treated with G. biloba extract. Almost a third of the untreated cells underwent apoptosis compared with approximately one in twenty of the treated cells. Parallel studies with laboratory mice also demonstrated a similar protective effect against radiation poisoning" - See Ginkgo biloba at Amazon.com.
  • Could Vitamin D Save Us From Radiation? - Science Daily, 11/7/08 - "calcitriol, the active form of vitamin D, may protect us from background radiation and could be used as a safe protective agent before or after a low-level nuclear incident" - See vitamin D at Amazon.com.
  • Plant Antioxidant May Protect Against Radiation Exposure - Science Daily, 9/23/08 - "Resveratrol, the natural antioxidant commonly found in red wine and many plants, may offer protection against radiation exposure ... Currently there are no drugs on the market that protect against or counteract radiation exposure"
  • Antioxidant Supplements May Lessen Benefit Of Radiation And Chemotherapy - Science Daily, 5/27/08
  • Antioxidants Could Provide All-purpose Radiation Protection - Science Daily, 11/5/07 - "Inositol and inositol hexaphosphate (IP6) protected both human skin cells and a skin cancer-prone mouse from exposure to ultraviolet B (UVB) radiation, the damaging radiation found in sunlight ... Twenty-three percent of treated mice developed tumors, compared to 51 percent of untreated, or control mice, which developed tumors. Moreover, the mice in the treated group that did develop cancer had only half as many tumors as the control mice" - See IP-6 products at Amazon.com.  Note:  IP-6 was one of the supplements I took when they told me I only had a small chance of survival from neck cancer.  Click here for the full story.  I still take it.
  • Vitamin E: Friend or Foe During Radiation Therapy? - Physician's Weekly, 7/16/07 - "Not only did it show that vitamin E supplementation was of no benefit to patients, but it was also associated with a nearly 40% increased risk of death when compared to study counterparts who received a placebo. Vitamin E, despite what patients may think, appears to be much more harmful for patients who have head and neck cancer who are receiving radiation therapy"
  • Tea Extracts Help Treat Damaged Skin In Cancer Patients - Science Daily, 11/1/06 - "tea extracts reduce the duration of radiation-induced skin damage by up to 10 days in patients who received radiation treatment"
  • Research Finds Antioxidant Therapies Do Not Interfere With Radiation Treatment - Science Daily, 11/12/06 - "Radiation Therapy for Prostate Cancer, was conducted by researchers ... Researchers found no difference between patients taking antioxidants and those who did not. Antioxidants used in the study included green tea extract, melatonin, high-potency multivitamins, vitamin C and vitamin E"
  • Are Antioxidants Safe During Chemotherapy and Radiation Treatment? - Healthwell Exchange Daily News, 9/29/05
  • Antioxidants may hamper cancer therapies - Nutra USA, 9/22/05 - "there are some indications that antioxidants can actually be harmful for patients being treated with chemotherapy or radiotherapy, since they may be unable to differentiate between normal cells and cancer cells. This may mean that treatment is rendered less effective"
  • Phytoestrogens and Antioxidants - Medscape, 1/26/05 - "What if exogenous antioxidants also protect the tumor? Should physicians, and in particular radiotherapists, advise against their use for patients undergoing radiation treatments? Or should they, instead, recommend them to prevent damage to normal tissues associated with treatment? ... No significant difference was seen in the amount of radiation required for tumor control between mice receiving antioxidants in their diet and control animals. There was, however, a trend toward a slightly higher dose needed for tumor eradication in antioxidant-treated mice. On the other hand, there was a significant difference in the damages induced by radiation treatment in the 2 groups: Vitamin E and GTE-treated mice showed partial protection of normal tissues from radiation injury"
  • Exercise Fights Fatigue of Radiation Therapy - WebMD, 8/4/04
  • Vitamin E Prevents Painful Radiation Therapy Side Effect - Healthwell Exchange Daily News, 6/10/04
  • Treatment for a Serious Side Effect: Vitamin E Improves Radiation Damage - Healthwell Exchange Daily News, 4/15/04
  • Natural Relief for Radiation Burns? - Dr. Weil, 1/29/04
  • Vitamin D May Augment Breast Cancer Treatments - Physician's Weekly, 5/19/03 - "treatment with vitamin D was three times more effective in preventing new tumor growth when compared to radiation therapy alone"
  • Curry Spice Takes Burn Out of Radiation - WebMD, 10/10/02 - "The study showed that curcumin, the substance in turmeric that gives it and the dishes it flavors a characteristic yellow color, is a natural anti-inflammatory compound. It works in ways similar to the popular Cox-2 inhibiting drugs, including aspirin and Celebrex"- - See curcumin supplements at Amazon.com.
  • In Praise of Spirulina - CancerDecisions.com, 12/12/02 - "Spirulina also shows potential for decreasing the adverse effects of both chemotherapy and radiation"
  • Oral Enzyme Therapy Reduces Radiation-Related Side Effects In Cervical Cancer - Doctor's Guide, 11/28/01 - See enzymes
  • Antioxidants Resolve Radiation Side Effects - Nutrition Science News, 9/01

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