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Anti-aging Research > Cruciferous Vegetables.
Cruciferous Vegetables
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Popular Supplements:
News & Research:
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Antioxidant found in vegetables has implications for treating cystic
fibrosis - 11/20/09 - "a dietary antioxidant
found in such vegetables as broccoli and cauliflower protects cells from
damage caused by chemicals generated during the body's inflammatory response
to infection and injury. The finding has implications for such
inflammation-based disorders as cystic fibrosis (CF), diabetes, heart
disease, and neurodegeneration ... the antioxidant thiocyanate normally
existing in the body protects lung cells from injuries caused by
accumulations of hydrogen peroxide and hypochlorite, the active ingredient
in household bleach. These potentially harmful chemicals are made by the
body as a reaction to infection and injury. In addition, thiocyanate also
protects cells from hypochlorite produced in reactions involving MPO, an
enzyme released from germ-fighting white blood cells during inflammation"
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Broccoli extract’s heart health benefits pinpointed? - Nutra USA, 9/7/09
- "Researchers from Imperial College London (ICL)
report that sulforaphane, a compound most widely associated with broccoli,
may activate a protein called Nrf2 in arteries ... the natural compound
sulforaphane reduced inflammation at the high-risk areas by 'switching on'
Nrf2 ... Atherosclerosis, known as hardening or furring of the arteries is a
key risk factor for cardiovascular disease, the cause of over 50 per cent of
deaths in Europe and the US ... When these cells were exposed to
sulforaphane, a re-activation of Nrf2 in the disease-prone regions of the
artery was observed. This indicated that the cells’ ability to protect
themselves from becoming inflamed was restored" - [Abstract]
- See
sulforaphane products at iHerb
 .
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Naturally Occurring Compounds Selectively Deplete Mutant P53 In Tumor Cells
- Science Daily, 4/20/09 - "This study demonstrates
for the first time that phenethyl isothiocyante (PEITC), a
naturally-occurring compound, can selectively deplete mutant p53. The
authors also made an intriguing observation that the depletion of mutant p53
in human cancer cells is accompanied by restoration of the wild type p53.
PEITC is a member of the isothiocyanate family compounds found in
cruciferous vegetables, such as watercress, broccoli and cabbage. PEITC has
been shown to have cancer preventive activity"
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Broccoli
May Help Protect Against Respiratory Conditions Like Asthma - Science Daily,
3/2/09 - "a naturally occurring compound found in
broccoli and other cruciferous vegetables
may help protect against respiratory inflammation that causes conditions like
asthma, allergic
rhinitis and chronic obstructive pulmonary disease
... sulforaphane, a chemical in broccoli, triggers an increase of antioxidant
enzymes in the human airway that offers protection against the onslaught of free
radicals that we breathe in every day in polluted air, pollen, diesel exhaust
and tobacco smoke" - See
sulforaphane products at iHerb.
-
Broccoli And Cabbage-based Drug Could Inhibit Melanoma - Science Daily,
3/1/09 - "We have developed drugs from naturally
occurring compounds that can inhibit the growth of tumors in mice by 50 to
60 percent with a very low dose ... Robertson and his colleagues previously
showed the therapeutic potential of targeting the Akt3 protein in inhibiting
the development of melanoma. The search for a drug to block the protein led
them to a class of compounds called isothiocyanates ... These naturally
occurring chemicals found in cruciferous vegetables are known to have
certain cancer-fighting properties ... Selenium deficiency is common in
cancer patients ... the selenium-enhanced compounds significantly reduced
the production of Akt3 protein and shut down its signaling network"
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How
Certain Vegetables Combat Cancer - Science Daily, 12/23/08 -
"Breast cancer, the second leading cause of cancer
deaths in women, can be protected against by eating cruciferous vegetables
such as cabbage and near relatives of cabbage such as broccoli and
cauliflower ... Our paper focuses on the anti-cancer activity of one of
these compounds, called sulforaphane, or SFN ... SFN inhibits the
proliferation of human tumor cells by a mechanism similar to the way that
the anticancer drugs taxol and vincristine inhibit cell division during
mitosis ... SFN, like the more powerful anticancer agents, interferes with
microtubule functioning during mitosis in a similar manner to the more
powerful anticancer drugs ... SFN may be an effective cancer preventive
agent because it inhibits the proliferation and kills precancerous cells"
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Broccoli May Help Smokers' Lungs - WebMD, 11/18/08 -
"asked 948 lung cancer patients and 1,743 people
without lung cancer about their smoking history and consumption of fruits,
cruciferous vegetables, and other vegetables ... Among smokers -- and
especially among former smokers -- higher intake of cruciferous vegetables
was linked to lower risk of lung cancer"
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Unpopular veggies vital for cancer protection: Study - Nutra USA,
10/7/08 - "Significant inhibition of all the cancer
cell lines tested – stomach, lung, breast, kidney, skin, pancreas, prostate,
and brain – was observed for all the extracts from cruciferous vegetables,
such as broccoli, kale, Brussels sprouts, and curly cabbage, and vegetables
of the genus Allium, such as garlic ... These chemopreventive effects are
likely related to the formation of organosulfur compounds following
mechanical disruption of these vegetables, namely isothiocyanates from
cruciferous and a series of allyl sulfur molecules from Allium vegetables"
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COPD? Eat Your Veggies - Science Daily, 9/12/08 -
"Sulforapane has been shown to be able to restore
antioxidant gene expression in human epithelial tissue in which DJ-1 has
been reduced. Isothicyanate compounds such as that found in broccoli inhibit
KEAP1, and thus prevent it from degrading NRF2"
-
Broccoli Could Reverse The Heart Damaging Effects Of Diabetes - Science
Daily, 8/26/08 - "Our study suggests that compounds
such as Sulforaphane from broccoli may help counter processes linked to the
development of vascular disease in diabetes"
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Broccoli can reverse diabetic heart damage, say researchers - Nutra USA,
8/8/08 - "Our study suggests that compounds such as
Sulforaphane from broccoli may help counter processes linked to the
development of vascular disease in diabetes ... Published in the journal
Diabetes Care, the epidemiological study of 71,346 female nurses found for
every additional serving of green leafy vegetables, the risk of developing
diabetes may be reduced by almost 10 per cent" - [Abstract]
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Activation of NF-E2-related factor-2 reverses biochemical dysfunction of
endothelial cells induced by hyperglycemia linked to vascular disease -
Diabetes. 2008 Aug 4 - "Sulforaphane (SFN) is an
activator of transcription factor NF-E2-related factor-2 (nrf2) that
regulates gene expression through the promoter antioxidant response element
(ARE). Nrf2 regulates the transcription of a battery of protective and
metabolic enzymes ... We conclude that activation of nrf2 may prevent
biochemical dysfunction and related functional responses of endothelial
cells induced by hyperglycemia in which increased expression of
transketolase has a pivotal role" - [Nutra
USA]
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Broccoli May Cut Prostate Cancer Risk - WebMD, 7/1/08 - [Science
Daily] - "men who regularly ate broccoli showed more changes
in gene expression suggestive of a reduced risk of cancer"
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Veggies, Exercise May Cut Cancer Risk - WebMD, 4/15/08 -
"Foods rich in plant chemicals called
isothiocyanates and quercetin appeared to offer the best protection against
lung cancer ... Isothiocyanates are found in cruciferous vegetables such as
broccoli, cabbage, cauliflower, brussels sprouts, and turnips"
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Could
foods prevent ovarian cancer? - MSNBC, 3/14/08 -
"Kaempferol — a flavonoid found in tea, broccoli, kale and spinach — and
luteolin — which is provided by peppers, carrots, cabbage and celery — were
both identified as cancer protective. Women who consumed the most of these
two flavonoids were 40 percent and 34 percent less likely, respectively, to
develop ovarian cancer compared to women who consumed the least ... A 2007
study published in the British Journal of Nutrition linked greater
consumption of carotenoid phytochemicals with a 67 percent lower risk of
ovarian cancer. This included not only beta-carotene, the oft-cited
carotenoid in deep-orange vegetables and fruits, but also alpha-carotene,
beta-cryptoxanthin, lutein and zeaxanthin — carotenoids found in a wide
range of red, orange, yellow and green vegetables" - See
Nature's Way, Multi-Carotene Anti-oxidant at iHerb.
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Broccoli May Help Boost Aging Immune System - Science Daily, 3/6/08 -
"As we age, the ability of the immune system to
fight disease and infections and protect against cancer wears down as a
result of the impact of oxygen radicals on the immune system ... our study
shows that a chemical present in broccoli is capable of stimulating a wide
range of antioxidant defense pathways and may be able to interfere with the
age-related decline in immune function ... The UCLA team not only found that
the direct administration of sulforaphane in broccoli reversed the decline
in cellular immune function in old mice, but they witnessed similar results
when they took individual immune cells from old mice, treated those cells
with the chemical outside the body and then placed the treated cells back
into a recipient animal"
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Extract Of Broccoli Sprouts May Protect Against Bladder Cancer - Science
Daily, 2/28/08 - "A concentrated extract of freeze
dried broccoli sprouts cut development of bladder tumors in an animal model
by more than half" - [WebMD]
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Finding the Right Prostate Cancer Diet - WebMD, 2/15/08 -
"poultry and eggs double the risk of prostate cancer
progression ... orange and yellow vegetables, such as squash, yams, and
carrots, and cruciferous vegetables, such as broccoli, cut the risk of
recurrence by about half ... If you eat chicken or poultry, eat it without
the skin ... the men's overall PSA doubling time was nearly four times
slower after they began drinking pomegranate juice"
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Vegetables- and antioxidant-related nutrients, genetic susceptibility, and
non-Hodgkin lymphoma risk - Cancer Causes Control. 2008 Jan 17 -
"For the GSTM3 3-base insertion and higher total
vegetable intake, the risk was 0.56 (0.35-0.92, p interaction = 0.03); for
GSTP1 A114V and higher cruciferous vegetable intake, the risk was 0.52
(0.34-0.81, p interaction = 0.02); for OGG1 S326C and higher daily zinc
intake, the risk was 0.71 (0.47-1.08, p interaction = 0.04) and for XRCC3
T241M and higher green leafy vegetable intake, the risk was 0.63"
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Broccoli Good for the Heart - WebMD, 1/18/08 -
"The rats that had eaten the broccoli extract had three heart advantages
over the other rats: ... Better blood-pumping ability ... Less heart damage
during oxygen deprivation ... Higher levels of heart-health chemicals during
oxygen deprivation ... Broccoli's key nutrients include selenium and
sulforaphane, which may also curb cancer"
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Is There an Anticancer Diet? - WebMD, 12/6/07 -
"Raw cruciferous vegetables such as broccoli, broccoli sprouts, cabbage, and
cauliflower seem to reduce bladder cancer risk by about 40%"
-
Natural Chemical Found In Broccoli Helps Combat Skin Blistering Disease
- Science Daily, 8/20/07
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Broccoli May Help Cut Prostate Cancer - WebMD, 7/24/07 -
"Men who reported eating cauliflower more than once
per week were 52% less likely to be diagnosed with aggressive prostate
cancer than men who reported eating cauliflower less than once a month ...
Men who reported eating broccoli more than once per week were 45% less
likely to be diagnosed with aggressive prostate cancer than men who reported
eating broccoli less than once a month"
-
Eat
Your Broccoli: Study Finds Strong Anti-Cancer Properties In Cruciferous
Veggies - Science Daily, 5/17/07 -
"if you’re at all worried about
cancer or at high risk of cancer, especially of prostate or colon cancer,
then increasing your dietary intake of broccoli and other vegetables could
be a good idea"
-
Boiling Broccoli Ruins Its Anti-cancer Properties, According To Study -
Science Daily, 5/15/07 - "Boiling
appeared to have a serious impact on the retention of those important
glucosinolate within the vegetables. The loss of total glucosinolate content
after boiling for 30 minutes was: broccoli 77%, Brussel sprouts 58%,
cauliflower 75% and green cabbage 65%"
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Nutrients In Certain Vegetables May Provide Cancer-fighting Benefit -
Science Daily, 4/17/07 - "Dr.
Singh's study is based on phytochemicals, called isothiocyanates (ITCs),
found in several cruciferous vegetables and generated when vegetables are
either cut or chewed. His laboratory has found that phenethyl-ITC, or PEITC,
is highly effective in suppressing the growth of human prostate cancer cells
at concentrations achievable through dietary intake"
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Worried About Prostate Cancer? Tomato-broccoli Combo Shown To Be Effective
- Science Daily, 1/16/07 - "fed a
diet containing 10 percent tomato powder and 10 percent broccoli powder to
laboratory rats that had been implanted with prostate cancer cells ... The
tomato/broccoli combo outperformed all other diets in shrinking prostate
tumors ... The only treatment that approached the tomato/broccoli diet's
level of effectiveness was castration ... To get these effects, men should
consume daily 1.4 cups of raw broccoli and 2.5 cups of fresh tomato, or 1
cup of tomato sauce, or ½ cup of tomato paste"
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Broccoli, Cauliflower May Fight Cancer - WebMD, 5/19/06
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Broccoli, Cauliflower And Genetic Cancer - Science Daily, 5/18/06 -
"cruciferous vegetables ... are
abundant in sulforaphane (SFN) ... those mice fed with an SFN-supplemented
diet developed significantly fewer and smaller tumors"
-
Crunchy Veggies Fight Cancer - WebMD, 4/5/06 -
"focused on a substance found in
cruciferous vegetables called phenethyl-ITC, or PEITC ... After 31 days of
treatment, the size of the tumors in the treated animals was about half that
of the untreated animals"
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Curry And Cauliflower Could Halt Prostate Cancer - Science Daily,
1/15/06 - "The bottom line is that
PEITC and curcumin, alone or in combination, demonstrate significant
cancer-preventive qualities in laboratory mice, and the combination of PEITC
and curcumin could be effective in treating established prostate cancers"
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Eat Your Veggies and Fight Cancer, Too - WebMD, 10/31/05
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Broccoli May Protect Some Against Lung Cancer - WebMD, 10/27/05 -
"consumption of cruciferous
vegetables was associated with a 33%-37% reduction in lung cancer risk among
people with an inactive form of one of the two genes. Among those with an
inactive form of both genes, the reduction in risk provided by eating
cruciferous vegetables was doubled to more than 70%"
-
Broccoli May Fight Lung Cancer - WebMD, 9/15/05
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Compounds Found In Cruciferous Vegetables Block Lung Cancer Progression
- Science Daily, 9/15/05 - "A family
of compounds found in cruciferous vegetables, such as broccoli, cauliflower,
and watercress, blocked lung cancer progression in both animal studies and
in tests with human lung cancer cells"
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Broccoli Ingredient May Fight Bladder Cancer - WebMD, 8/3/05
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Broccoli Packs Powerful Punch To Bladder Cancer Cells - Science Daily,
7/29/05 - "men who ate two or more
half-cup servings of broccoli per week had a 44 percent lower incidence of
bladder cancer compared to men who ate less than one serving each week ...
The plant's kin, which include cabbage, cauliflower, Brussels sprouts and
kale, may all contain similar disease-fighting phytochemicals"
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Cruciferous veg, chili could slow or stop cancer cell growth - Nutra
USA, 4/20/05
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Maximizing The Anti-Cancer Power Of Broccoli - Science Daily, 4/5/05 -
"For the consumer, who cannot
readily hold the temperature as low as 140 degrees, that means the best way
to prepare broccoli is to steam it lightly about 3 or 4 minutes--until the
broccoli is tough-tender"
- Ward off
cancer with a Japanese diet - MSNBC, 12/17/04 - "Cruciferous vegetables make a unique contribution to good health. They
contain natural substances called glucosinolates
that break down in the body to form
indoles
and other compounds that fight cancer development in several different ways"
- An Apple a Day for Cancer Prevention - WebMD,
10/18/04 - "Those
who ate both green leafy and cruciferous vegetables got "particularly
strong" cancer prevention protection"
- Crunchy Veggies May Crush Breast Cancer - WebMD,
9/3/04
- Anti-cancer Compound In Vegetables Found To Block Late-stage Breast-cancer
Cell Growth - Science Daily, 9/1/04 - "The compound, in broccoli and other cruciferous vegetables ...
sulforaphane (SUL)
... We were surprised and pleased to find that
SUL could block the growth of
breast cells that were already cancerous ...
SUL's
actions appear similar to a group of anticancer drugs currently in use, such
as Taxol"
- Broccoli compound may protect against AMD - Nutra
USA, 7/15/04
- Broccoli May Prevent Blindness - WebMD, 7/13/04 -
"sulforaphane,
the naturally occurring antioxidant in broccoli and broccoli sprouts,
protects the eye from damage caused by the sun's ultraviolet light"
- Cabbage to fight cancer? - Nutra USA, 5/11/04
- Broccoli Blocks Prostate Cancer Cells - WebMD,
5/20/03
- New Broccoli Compound Appears Promising Against Breast Cancer
- Intelihealth, 8/19/02 - "Called
oxomate, the synthetic
compound works like its natural counterpart,
sulforaphane, which was
recently identified as a cancer-preventive agent in broccoli and other
cruciferous vegetables (such as cabbage and Brussels sprouts). Both
compounds boost the body's production of phase II enzymes, which can
detoxify cancer-causing chemicals and reduce cancer risk ... But the natural
broccoli compound,
sulforaphane, can be toxic in
high doses ... It is also difficult and expensive to synthesize ...
oxomate was seven times less
toxic than sulforaphane
... In tests on female rats, those that were fed
oxomate
after exposure to cancer-inducing chemicals had up to a 50 percent reduction
in the number of breast tumors"
- Broccoli Pill Prevents Breast Cancer - WebMD,
8/19/02
- Broccoli Beats Ulcers, Cancer - WebMD, 5/28/02
-
Broccoli Tea: Can't Find Enough Of A Good Thing - Natural Foods
Merchandiser, 5/02
- Broccoli Finally Gets Respect - Intelihealth,
2/4/02
-
New research shows how broccoli beats cancer - Life Extension Magazine,
11/01 - "Sulforaphane
is most highly concentrated in broccoli, as well as in other cruciferous
vegetables, such as Brussels sprouts, cabbage and cauliflower ... animal
studies to date have shown that
sulforaphane
can dramatically reduce the number of malignant tumors, reproduction, growth
rate and size, as well as delay cancer onset"
-
Veggies Not Created Equal In Fighting Cancer - Intelihealth, 1/18/01 -
"But
the Agriculture Department studied 71 types of broccoli plants and found a
30-fold difference in the amounts of glucoraphanin. Some had virtually none
of it."
-
One More Reason To Eat Your Broccoli, Chemical Compounds Found to Prevent
Lung Cancer - WebMD, 8/25/00
-
Prostate Cancer and Cruciferous Vegetables - Life Extension Magazine,
7/00
-
Phytochemicals: Nutrients Whose Time Has Come - Nutrition Science News,
7/00
-
Betting on Broccoli - WebMD, 4/3/00
-
Fruits & Vegetables Slash Strokes - Nutrition Science News, 1/00
-
Can Cirrhosis be Prevented? - Nutrition Science News, 1/99
Abstracts:
-
Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a
Proinflammatory State - Arterioscler Thromb Vasc Biol. 2009 Sep 3 -
"Treatment with sulforaphane, a dietary antioxidant,
activated Nrf2 and suppressed p38-VCAM-1 signaling at the susceptible site
in wild-type but not Nrf2(-/-) animals, indicating that it suppresses EC
activation via Nrf2 ... Nrf2 prevents ECs at the atheroprotected site from
exhibiting a proinflammatory state via the suppression of p38-VCAM-1
signaling. Pharmacological activation of Nrf2 reduces EC activation at
atherosusceptible sites and may provide a novel therapeutic strategy to
prevent or reduce atherosclerosis" - See
sulforaphane products at iHerb.
-
Indole-3-carbinol Inhibits Sp1-Induced Matrix Metalloproteinase-2 Expression
To Attenuate Migration and Invasion of Breast Cancer Cells - J Agric
Food Chem. 2008 Dec 5 - "Indole-3-carbinol
(I3C), a major indole metabolite in cruciferous vegetables, has been shown
to inhibit invasion of breast cancer cells ... Migration, invasion, and
MMP-2 activity of MCF-7 breast cancer cells were dose-dependently inhibited
by I3C. In addition, the MMP-2 mRNA level was also reduced by I3C ... In
addition, I3C inhibited the extracellular signal-regulated kinase (ERK)
signaling pathway in MCF-7 cells. The results suggest that I3C inhibits
MMP-2 expression by blocking the ERK/Sp1-mediated gene transcription to
attenuate migration and invasion of breast cancer cells" - See
I3C products at iHerb.
-
Consumption of Raw Cruciferous Vegetables is Inversely Associated with
Bladder Cancer Risk - Cancer Epidemiol Biomarkers Prev. 2008
Apr;17(4):938-44 - "We observed a strong and
statistically significant inverse association between bladder cancer risk
and raw cruciferous vegetable intake (adjusted OR for highest versus lowest
category = 0.64; 95% CI, 0.42-0.97), with a significant trend (P = 0.003);
there were no significant associations for fruit, total vegetables, or total
cruciferous vegetables ... These data suggest that cruciferous vegetables,
when consumed raw, may reduce the risk of bladder cancer, an effect
consistent with the role of dietary isothiocyanates as chemopreventive
agents against bladder cancer"
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Broccoli: A Unique Vegetable That Protects Mammalian Hearts through the
Redox Cycling of the Thioredoxin Superfamily - J Agric Food Chem. 2007
Dec 29 - "the results of the present study indicate
that the consumption of broccoli triggers cardioprotection by generating a
survival signal through the activation of several survival proteins and by
redox cycling of thioredoxins"
-
Cruciferous vegetables, genetic polymorphisms in glutathione s-transferases
m1 and t1, and prostate cancer risk - Nutr Cancer.
2004;50(2):206-13 - "two or more servings
per month of cruciferous vegetables may reduce risk of prostate cancer"
- Breast Cancer Risk in Premenopausal Women Is Inversely Associated with
Consumption of Broccoli, a Source of Isothiocyanates, but Is Not Modified by
GST Genotype
- J Nutr. 2004 May;134(5):1134-1138 - "These data indicate that cruciferous vegetables may play an important role
in decreasing the risk of
premenopausal
breast cancer"
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