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Home > Health Conditions > Ovarian Cancer

Ovarian Cancer

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  • Supplemental Selenium May Decrease Ovarian Cancer Risk in African-American Women - J Nutr. 2017 Feb 15 - "Women with the highest intakes of supplemental selenium (>20 μg/d) had an ~30% lower risk of ovarian cancer than those with no supplemental intake (OR: 0.67"
  • Docosahexaenoic acid induces growth suppression on epithelial ovarian cancer cells more effectively than eicosapentaenoic acid - Nutr Cancer. 2016 Mar 4:1-8 - "Omega-3 fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to possess definitively suppressive effects on the growth of epithelial ovarian cancer cells ... In all cases, the effect of DHA was significantly more potent than that of EPA (P < 0.05). Our findings suggested that DHA may be more effective than EPA in growth suppression of TOV-21G cells and the biologic effects may be partly mediated by PPARγ and p53 activation" - See docosahexaenoic acid at Amazon.com.
  • Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells - Cancer Lett. 2015 Dec 15 - "resveratrol induced endoplasmic reticulum (ER) stress-mediated apoptosis by interrupting protein glycosylation in a cancer-specific manner. Our results indicated that resveratrol suppressed the hexosamine biosynthetic pathway and interrupted protein glycosylation through GSK3β activation ... Resveratrol-mediated disruption of protein glycosylation induced cellular apoptosis as indicated by the up-regulation of GADD153, followed by the activation of ER-stress sensors (PERK and ATF6α). Thus, our results provide novel insight into cancer cell metabolism and protein glycosylation as a therapeutic target for cancers" - See ReserveAge Resveratrol Vegetarian Capsules, 500 Mg, 60-Count at Amazon.com.
  • Curcumin induces apoptosis by inhibiting sarco/endoplasmic reticulum ca2+ ATPase activity in ovarian cancer cells - Cancer Lett. 2015 Nov 19 - "Curcumin induced apoptosis in ovarian cancer cells in a concentration- and time- dependent manner" - See curcumin products at Amazon.com.
  • Metformin reduces ovarian cancer risk in Taiwanese women with type 2 diabetes mellitus - Diabetes Metab Res Rev. 2015 Mar 28 - "The overall fully adjusted hazard ratio (95% confidence intervals) for ever- versus never-users was 0.658 (0.593-0.730). The fully adjusted hazard ratios for the first, second, and third tertiles of cumulative duration of metformin therapy were 1.169 (1.019-1.341), 0.761 (0.644-0.898) and 0.276 (0.225-0.340), respectively (P-trend <0.01); and 1.220 (1.067-1.395), 0.610 (0.513-0.725) and 0.305 (0.248-0.374), respectively (P-trend <0.01), for cumulative dose of metformin" - See metformin at IAS.
  • Tea, citrus products could lower ovarian cancer risk, new research finds - Science Daily, 10/28/14 - "The research reveals that women who consume foods containing flavonols and flavanones (both subclasses of dietary flavonoids) significantly decrease their risk of developing epithelial ovarian cancer ... The main sources of these compounds include tea and citrus fruits and juices" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Diet Quality and Survival After Ovarian Cancer: Results From the Women's Health Initiative - J Natl Cancer Inst. 2014 Oct 21;106(11) - "Overall, higher diet quality was associated with lower all-cause mortality after ovarian cancer (hazard ratio [HR] for highest vs lowest tertile = 0.73"
  • The prognostic value of metformin for cancer patients with concurrent diabetes- a systematic review and meta-analysis - Diabetes Obes Metab. 2014 Jan 27 - "A literature search was performed using the PubMed, EMbase and SciVerse Scopus databases ... metformin was associated with lower risk of all-cause mortality in cancer patients with concurrent diabetes, particularly for breast (pooled relative risk (RR) 0.70, 95% CI 0.55, 0.88; P=0.003), colorectal (RR 0.70, 95% CI 0.59, 0.84; P<0.001), ovarian (RR 0.44, 95% CI 0.30, 0.64; P<0.001) and endometrial cancer (RR 0.49, 95% CI 0.32, 0.73; P=0.001). In addition, metformin was associated with lower risks of cancer-specific mortality" - See metformin at IAS.
  • Anti-inflammatory effects of fish oil in ovaries of laying hens target prostaglandin pathways - Lipids Health Dis. 2013 Oct 24;12(1):152 - "The domestic hens spontaneously develop ovarian adenocarcinomas that share similar histological appearance and symptoms such as ascites and metastasis with humans. There is a link between chronic inflammation and cancer ... Our findings suggest that the lower doses of fish oil reduce inflammatory PG and may be an effective approach in preventing ovarian carcinogenesis. These findings may provide the basis for clinical trials utilizing fish oil as a dietary intervention targeting prostaglandin biosynthesis for the prevention and treatment of ovarian cancer" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Silibinin inhibits tumor growth through down-regulation of ERK and Akt in vitro and in vivo in human ovarian cancer cells - J Agric Food Chem. 2013 Apr 9 - "These results indicate that silibinin reduces tumor growth through inhibition of ERK and Akt in human ovarian cancer cells. These data suggest that silibinin may serve as a potential therapeutic agent for human ovarian cancers" - See silymarin at Amazon.com.
  • Diabetes Drug Metformin May Fight Cancer - WebMD, 12/3/12 - "The study is just one of dozens under way worldwide examining the drug -- which costs just pennies a pill -- as a treatment for breast, colon, prostate, pancreatic, and ovarian cancers ... After five years, 67% of women who took metformin had not died from ovarian cancer, compared to 47% of women without diabetes who did not take the drug ... The survival difference in the two groups was striking ... Every way we looked at this, the metformin group always did better ... If metformin really does fight cancer, it may do so by lowering circulating insulin levels in the blood" - [Science Daily] - See metformin at IAS.
  • Folate, vitamin B(6) , vitamin B(12) , methionine and alcohol intake in relation to ovarian cancer risk - Int J Cancer. 2011 Sep 22 - "Folate, methionine, vitamin B(6) , and vitamin B(12) may influence carcinogenesis due to their roles in the one-carbon metabolism pathway which is critical for DNA synthesis, methylation, and repair. Low intake of these nutrients has been associated with an increased risk of breast, colon, and endometrial cancers ... We observed an inverse association between dietary vitamin B(6) (covariate-adjusted OR=0.76, 95% CI 0.64-0.92; p(trend) =0.002) and methionine intake (covariate-adjusted OR=0.72, 95% CI=0.60-0.87; p(trend) <0.001) and ovarian cancer risk comparing the highest to lowest quartile. The association with dietary vitamin B(6) was strongest for serous borderline (covariate-adjusted OR=0.49, 95% CI=0.32-0.77; p(trend) =0.001) and serous invasive (covariate-adjusted OR=0.74, 95% CI=0.58-0.94; p(trend) =0.012) subtypes. Overall, we observed no significant association between folate and ovarian cancer risk. One-carbon metabolism related nutrients, especially vitamin B(6) and methionine, may lower ovarian cancer risk"
  • Independent and joint effects of serum 25-hydroxyvitamin D and calcium on ovarian cancer risk: A prospective nested case-control study - Eur J Cancer. 2010 Jun 18 - "We observed a significant inverse association between calcium and ovarian cancer risk. Relative risk (estimated as odds ratio, OR) comparing the highest quartile to the lowest quartile was significantly decreased; 0.41 [95% confidence interval (CI) 0.19-0.85, P-trend 0.004]. Even though a comparable association between 25-OHD and ovarian cancer did not reach statistical significance (OR 0.57, 95% CI 0.26-1.24, P-trend 0.07), having sufficient (>75nmol/L) serum 25-OHD levels compared to insufficient serum 25-OHD was associated with a significantly decreased risk of ovarian cancer (OR 0.32; 95% CI 0.12-0.91, p-value 0.03)"
  • Tea consumption and risk of ovarian cancer - Cancer Causes Control. 2010 May 20 - "We also systemically reviewed all the available evidence regarding the potential association between green tea and risk of ovarian cancer, given the abundance of bioavailable polyphenols and higher antioxidant capacity of green tea than black tea, to provide the best summary estimate of the association. RESULTS: In our case-control study, while we found uniformly inverse odds ratios (OR) for tea drinkers compared to non-tea drinkers [4 + cups/day any tea OR 0.71 (95% CI 0.52-0.97); green tea OR 0.82 (95% CI 0.38-1.79); herbal tea OR 0.77 (95% CI 0.28-2.14): black tea OR 0.88 (95% CI 0.66-1.18)], we saw no dose-response trends. Our meta-analysis provided some evidence that women who drink green tea have a lower risk of ovarian cancer, although the summary estimate did not reach statistical significance (0.58, 95% CI 0.33-1.01 for >/=1 cup/green tea day). This result is consistent with two recent meta-analyses that evaluated the association of tea (all types combined) and ovarian cancer risk" - See green tea extract at Amazon.com.
  • Curcumin nanoparticles 'open up' resistant cancers - Science Daily, 4/28/10 - "Pre-treatment with curcumin, a component of the spice turmeric, makes ovarian cancer cells more vulnerable to chemotherapy and radiotherapy"
  • Good Diet May Aid Ovarian Cancer Survival - WebMD, 3/4/10 - "five years, 75% of the women who ate less than one serving a week of yellow vegetables were alive, compared to about 82% of those who had three or more servings of yellow vegetables a week ... When the researchers looked at red meat lovers vs. avoiders, "we found almost a threefold risk of dying for those women who ate four or more servings of red meat a week compared to those who ate less than one serving per week over the 11-year study period"
  • Isoflavones and Flavonols Reduce Ovarian Cancer Risk - oncologystat.com, 8/22/08 - "Women with the highest flavonoid intake had a 37% lower risk of ovarian cancer than those with the lowest intake. A high intake of isoflavones, in particular, was associated with a 49% decreased ovarian cancer risk"
  • Flavonoids and ovarian cancer risk: A case-control study in Italy - Int J Cancer. 2008 May 19 - "In logistic regression models including study center, education, year of interview, parity, oral contraceptive use and family history of ovarian or breast cancer or both, an inverse relation with significant trend in risk was found between ovarian cancer and flavonols [odds ratio (OR), 0.63; 95% confidence intervals (CI) 0.47-0.84] as well as isoflavones (OR, 0.51; 95% CI, 0.37-0.69), comparing the highest versus the lowest quintile. Further adjustment for fruit and vegetable intake did not modify these associations, suggesting that isoflavones and flavonols may have a distinct role in explaining the effect of fruit and vegetable against ovarian cancer. On the basis of our findings and the relevant literature, we infer that isoflavones, and perhaps flavonols, may have favorable effects with respect to ovarian cancer risk" - See bioflavonoids at Amazon.com.
  • Coffee, tea, colas, and risk of epithelial ovarian cancer - Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):712-6 - "Neither caffeinated nor decaffeinated coffees were associated with ovarian cancer risk; also, we observed no association of total caffeine with risk using a combined index that summed intake from coffee, tea, and carbonated soft drinks. Among teas, neither herbal/decaffeinated nor black teas were associated with risk; however, women who reported drinking >/=1 cup/d of green tea had a 54% reduction in risk" - See green tea extract at Amazon.com.
  • Could foods prevent ovarian cancer? - MSNBC, 3/14/08 - "Kaempferol — a flavonoid found in tea, broccoli, kale and spinach — and luteolin — which is provided by peppers, carrots, cabbage and celery — were both identified as cancer protective. Women who consumed the most of these two flavonoids were 40 percent and 34 percent less likely, respectively, to develop ovarian cancer compared to women who consumed the least ... A 2007 study published in the British Journal of Nutrition linked greater consumption of carotenoid phytochemicals with a 67 percent lower risk of ovarian cancer. This included not only beta-carotene, the oft-cited carotenoid in deep-orange vegetables and fruits, but also alpha-carotene, beta-cryptoxanthin, lutein and zeaxanthin — carotenoids found in a wide range of red, orange, yellow and green vegetables" - See Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.com.
  • Ovarian Cancer Risk Not Affected By Alcohol And Smoking, But Reduced By Caffeine, Study Finds - Science Daily, 1/22/08 - "they observed an inverse trend of risk with total caffeine and caffeinated coffee intake, but no association with decaffeinated coffee"
  • Flavonoid-rich Diet Helps Women Decrease Risk Of Ovarian Cancer - Science Daily, 11/19/07 - "the researchers found a 40 percent reduction in ovarian cancer risk among the women with the highest kaempferol intake, compared with women with the lowest intake. They also found a 34 percent reduction in the risk of ovarian cancer among women with the highest intake of luteolin, compared with women with the lowest intake"
  • Deficiency In Exposure To Sunlight Linked To Endometrial Cancer - Science Daily, 11/14/07 - "In general, endometrial cancer incidence was highest at the highest latitudes in both hemispheres ... This is the third environmental paper from this research team to show a strong association between vitamin D and cancer using global incidence data (GLOBOCAN). The first paper, which illuminated a similar pattern for kidney cancer, was published Sept. 15, 2006, in the International Journal of Cancer. The second, on ovarian cancer, was published Oct. 31, 2006, in the American Journal of Preventive Medicine" - See vitamin D at Amazon.com.
  • Low-fat Dietary Pattern May Lower Risk Of Ovarian Cancer - Science Daily, 10/9/07 - "after four years, women who decreased the amount of dietary fat they consumed were 40 percent less likely to develop ovarian cancer than women who followed normal dietary patterns. As expected, no effect was found during the first four years because preventive benefits on cancer often take many years to develop"
  • Glycaemic index, glycaemic load and ovarian cancer risk: a prospective cohort study - Public Health Nutr. 2007 Oct;10(10):1076-81 - "Glyacemic index (GI) and glycaemic load (GL) .. GI and total carbohydrate and sugar intakes were not associated with ovarian cancer risk in the total cohort. GL was positively associated with a 72% increase in risk of ovarian cancer"
  • Cranberries Give Boost to Cancer Drug - WebMD, 8/21/07 - "compounds isolated from cranberries kill human ovary, brain, and prostate cells in laboratory studies ... in the presence of cranberry extract -- which came from a commercially available, 27% juice cranberry drink -- platinum-based chemotherapy was six times more effective against platinum-resistant ovarian cancer cells" - See cranberry extract at Amazon.com.
  • Role of ultraviolet B irradiance and vitamin d in prevention of ovarian cancer - Am J Prev Med. 2006 Dec;31(6):512-4 - "Solar UVB irradiance was inversely associated with incidence rates of ovarian cancer in this study, adding new evidence to the theory that vitamin D might play a role in the prevention of ovarian cancer"
  • Deficiency In Exposure To Sunlight Linked To Ovarian Cancer - Science Daily, 11/2/06 - "This new global study shows a link between deficiency of vitamin D and increased incidence of ovarian cancer, suggesting that vitamin D supplementation may reduce the incidence of this aggressive cancer"
  • Tea May Fight Ovarian, Breast Cancers - WebMD, 4/5/06 - "women who increase their consumption of kaempferol, a type of flavonoid, can lower their risk of ovarian cancer by nearly 40% ... women who consume a diet rich in other types of flavonoids - specifically, flavones, flavan-3-ols, and lignans -- can reduce their chance of developing breast cancer by 26% to 39%" - See green tea extract at Amazon.com.
  • Ginger an Ovarian Cancer Killer - HealthDay, 4/5/06 - "ginger helps control inflammation, which contributes to the development of ovarian cancer cells. By halting inflammation, ginger may stop cancer cells from growing"
  • Can tea help prevent ovarian cancer? - MSNBC, 2/24/06
  • Drinking Tea Associated With Lower Risk Of Ovarian Cancer - Science Daily, 1/3/06 - "We observed a 46 percent lower risk of ovarian cancer in women who drank two or more cups of tea per day compared with non-drinkers"
  • Tea May Cut Ovarian Cancer Risk - WebMD, 12/12/05 - "Women who drank at least 2 cups of tea per day had a 46% lower risk of ovarian cancer compared with nontea drinkers; each additional cup of tea was associated with an 18% lower risk of ovarian cancer" - See green tea extract at Amazon.com.
  • Tea consumption and ovarian cancer risk in a population-based cohort - Arch Intern Med. 2005 Dec 26;165(22):2683-6 - "Each additional cup of tea per day was associated with an 18% lower risk of ovarian cancer"
  • Gingko biloba may reduce ovarian cancer risk - Nutra USA, 11/2/05 - "Women who took gingko supplements for six months or longer were shown to have a 60 per cent lower risk for ovarian cancer" - See ginkgo biloba at Amazon.com.
  • Regular Moderate Exercise May Decrease The Risk Of Ovarian Cancer - Science Daily, 5/21/05
  • Regular Moderate Exercise May Lower Ovarian Cancer Risk - Medscape, 5/16/05
  • Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy - Gynecol Oncol. 2004 May;93(2):320-327 - "we conclude that there are beneficial effects caused by ingesting selenium, as a supportive element in chemotherapy" - See iHerb selenium products.
  • Folate may protect against ovarian cancer too - Nutra USA, 3/16/04
  • Folate May Protect Against Ovarian Cancer - WebMD, 3/2/04 - "women who drank about two drinks per week had a 74% lower risk of ovarian cancer if they also ate a folate-rich diet compared with women who got the least amount of folate from foods in their diet"
  • Detecting an Insidious Cancer? - Dr. Weil, 5/27/03
  • Antioxidant Vitamins Associated with Reduced Risk of Ovarian Cancer - New Hope Natural Media, 5/23/02 - "Women taking the most supplemental vitamin C (over 90 mg per day) had a 60% lower risk of ovarian cancer, compared with women not taking vitamin C ... women taking amounts of vitamin E above 30 mg per day (this would be approximately 30 IU of synthetic or 45 IU of natural vitamin E per day) had a 67% reduction in ovarian cancer risk, compared with women not taking vitamin E ... antioxidants from the diet were not found to offer significant protection against ovarian cancer"
  • Exposure To Sunlight Lowers Risks Of Four Cancers - Doctor's Guide, 4/4/02 - "exposure to sunlight contributes to non-melanoma skin cancer. "By contrast, several ecological studies suggest that sunlight may protect against female breast, ovarian, prostate, and colon cancer, all diseases that contribute to a substantially higher proportion of cancer mortality in the western industrialized world." ... Some studies have suggested an association between circulating vitamin D in blood, which is largely derived from sunlight, or dietary vitamin D and colorectal, prostate and female breast cancers"
  • Can Aspirin Help Prevent Ovarian Cancer? - WebMD, 3/7/01
  • Study Suggests Aspirin Offers Protective Benefit Against Ovarian Epithelial Cancer - Doctor's Guide, 3/7/01
  • Frequent aspirin doses cut risk of ovarian cancer - USA Today, 3/6/01 - "Taking aspirin three or more times a week for at least six months appeared to cut women's risk of developing the most common type of ovarian cancer by 40%"

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