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Home > Anti-aging Research > Glycine


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  • Improved Cardiovascular Function in Old Mice after N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors - J Gerontol A Biol Sci Med Sci. 2018 Mar 10 - "Metabolic, inflammatory and functional changes occur in cardiovascular aging which may stem from oxidative stress and be remediable with antioxidants. Glutathione, an intracellular antioxidant, declines with aging, and supplementation with glutathione precursors, N-Acetyl Cysteine (NAC) and Glycine (Gly), increases tissue glutathione. Thirty month-old mice were fed diets supplemented with NAC or NAC+Gly and, after seven weeks, cardiac function and molecular studies were performed.The NAC+Gly supplementation improved diastolic function, increasing peak early filling velocity, and reducing relaxation time, left atrial volume, and left ventricle end diastolic pressure. By contrast, cardiac function did not improve with NAC alone. Both diet supplementations decreased cardiac levels of inflammatory mediators; only NAC+Gly reduced leukocyte infiltration. Several mitochondrial genes reduced with aging were upregulated in hearts by NAC+Gly diet supplementation. These Krebs cycle and oxidative phosphorylation enzymes, suggesting improved mitochondrial function, and permeabilized cardiac fibers from NAC+Gly fed mice produced ATP from carbohydrate and fatty acid sources, whereas fibers from control old mice were less able to utilize fatty acids" - See glycine products at Amazon.com and n-acetyl cysteine at Amazon.com.
  • Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice - Clin Nutr. 2015 Sep 25 - "GLY treated mice lost more whole-body fat mass (14%, p < 0.05) and epididymal fat mass (26%, P < 0.05), less lean mass (27%, P < 0.05), and had better preserved quadriceps muscle mass (4%, P < 0.01) than ALA treated mice after 20 d CR ... Taken together, these findings suggest that glycine supplementation during CR may be beneficial for preserving muscle mass and stimulating loss of adipose tissue"
  • Dietary glycine and blood pressure: the International Study on Macro/Micronutrients and Blood Pressure - Am J Clin Nutr. 2013 May 8 - "The study was a cross-sectional epidemiologic study that involved 4680 persons aged 40-59 y from 17 random population samples in the People's Republic of China, Japan, the United Kingdom, and the United States ... glycine, but not alanine, was significantly related to BP. Estimated average BP differences associated with a 2-SD higher glycine intake (0.71 g/24 h) were 2.0-3.0-mm Hg systolic BP (z = 2.97-4.32) stronger in Western than in East Asian participants. In Westerners, meat was the main dietary source of glycine but not in East Asians (Chinese: grains/flour and rice/noodles; Japanese: fish/shellfish and rice/noodles)"
  • Orally administered L-arginine and glycine are highly effective against acid reflux esophagitis in rats - Med Sci Monit. 2011 Dec 22;18(1):BR9-15 - "L-alanine and L-glutamine exert a deleterious effect on the esophagitis, while L-arginine and glycine are highly protective" - See L-arginine products at Amazon.com and L-glycine at Amazon.com.
  • Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation - Am J Clin Nutr. 2011 Jul 27 - "Compared with younger control subjects, elderly subjects had markedly lower RBC concentrations of glycine (486.7 +/- 28.3 compared with 218.0 +/- 23.7 μmol/L; P < 0.01), cysteine (26.2 +/- 1.4 compared with 19.8 +/- 1.3 μmol/L; P < 0.05), and glutathione (2.08 +/- 0.12 compared with 1.12 +/- 0.18 mmol/L RBCs; P < 0.05); lower glutathione fractional (83.14 +/- 6.43% compared with 45.80 +/- 5.69%/d; P < 0.01) and absolute (1.73 +/- 0.16 compared with 0.55 +/- 0.12 mmol/L RBCs per day; P < 0.01) synthesis rates; and higher plasma oxidative stress (304 +/- 16 compared with 346 +/- 20 Carratelli units; P < 0.05) and plasma F(2)-isoprostanes (97.7 +/- 8.3 compared with 136.3 +/- 11.3 pg/mL; P < 0.05). Precursor supplementation in elderly subjects led to a 94.6% higher glutathione concentration, a 78.8% higher fractional synthesis rate, a 230.9% higher absolute synthesis rate, and significantly lower plasma oxidative stress and F(2)-isoprostanes. No differences in these measures were observed between younger subjects and supplemented elderly subjects ... Glutathione deficiency in elderly humans occurs because of a marked reduction in synthesis. Dietary supplementation with the glutathione precursors cysteine and glycine fully restores glutathione synthesis and concentrations and lowers levels of oxidative stress and oxidant damages. These findings suggest a practical and effective approach to decreasing oxidative stress in aging" - See l-glycine products at iHerb and n-acetyl cysteine at Amazon.com.
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