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Recent Longevity News for the week ending 6/22/22

Could a Type 2 Diabetes Drug Tackle Kidney Stones? - Medscape, 6/20/22 - "Patients with type 2 diabetes who received empagliflozin, a sodium glucose cotransporter-2 (SGLT2) inhibitor, were almost 40% less likely to have a kidney stone than patients who received placebo during a median 1.5 years of treatment ... Because SGLT2 inhibitors increase urinary glucose excretion through reduced renal reabsorption of glucose leading to osmotic diuresis and increased urinary flow, they hypothesized that these therapies "may reduce the risk of upper urinary tract stones (nephrolithiasis) by reducing the concentration of lithogenic substances in urine." - See empagliflozin inhousepharmacy.vu.

What to look for in multivitamins - Washington Post, 6/19/22 - "What vitamins should be in your multivitamin ... Vitamin A 700-1,050 mcg (2,300-3,500 IU) ... Vitamin C 60-300 mg ... Vitamin D 20-25 mcg (800-1,000 IU) ... Vitamin E 13-35 mg (20-80 IU) ... Vitamin K 20 mcg or more ... Thiamin (B-1) 1.1 mg or more ... Riboflavin (B-2) 1.1 mg or more ... Niacin (B-3) 14-20 mg ... Vitamin B-6 1.7-6 mg ... Folate Premenopausal women 660-680 mcg DFE (dietary folate equivalent) (400 mcg folic acid); everyone else 400-680 mcg DFE (235-400 mcg folic acid) ... Vitamin B-12 2.4 mcg or more ... Calcium Don’t rely on a multivitamin ... Iron Premenopausal women 18 mg; everyone else (no more than 8 mg) ... Iodine 150 mcg ... Magnesium 40-350 mg ... Zinc 8-24 mg ... Selenium 18-55 mcg ... Copper 0.5-2.2 mg ... Chromium 25 mcg or more ...Potassium Don’t rely on a multivitamin"

How psilocybin, the psychedelic in mushrooms, may rewire the brain to ease depression, anxiety and more - CNN, 6/11/22 - "Small clinical trials that have shown that one or two doses of psilocybin, given in a therapeutic setting, can make dramatic and long-lasting changes in people suffering from treatment-resistant major depressive disorder, which typically does not respond to traditional antidepressants ... Psilocybin, which the intestines convert into psilocin, a chemical with psychoactive properties, is also showing promise in combating cluster headaches, anxiety, anorexia, obsessive-compulsive disorder and various forms of substance abuse ... The data are strong from depression to PTSD to cluster headaches, which is one of the most painful conditions I'm aware of ... With psychedelics such as psilocybin and LSD, however, scientists can see changes in brain neuron connectivity in the lab "within 30 minutes ... There's more. Researchers say psychedelic drugs actually help neurons in the brain sprout new dendrites, which look like branches on a tree, to increase communication between cells"

EPA warns toxic ‘forever chemicals’ more dangerous than once thought - Washington Post, 6/15/22 - "Agency officials assessed two of the most common ones, known as PFOA and PFOS, in recent human health studies and announced Wednesday that lifetime exposure at staggeringly low levels of 0.004 and 0.02 parts per trillion, respectively, can compromise the immune and cardiovascular systems and are linked to decreased birth weights ... Those drinking-water concentrations represent “really sharp reductions” from previous health advisories set at 70 parts per trillion in 2016 ... The advisories’ levels are so low that they are difficult to detect with today’s technology ... ather than wait for the outcome of this peer review, EPA has announced new Advisories that are 3,000 to 17,000 times lower than those released by the Obama Administration in 2016 ... Already in the United States, manufacturers have largely replaced PFOA and PFOS with other fluorinated compounds. The EPA determined that two of those alternatives — dubbed GenX and PFBS — also are dangerous to ingest even at relatively low levels, according to a review of recent research on mice."

Association of Metformin Use With Risk of Venous Thromboembolism in Adults With Type 2 Diabetes - Medscape, 6/14/22 - "Among 117,472 initiators of metformin and 13,835 initiators of sulfonylureas, 555 (1.3/1,000 person-years) and 75 (2.1/1,000 person-years) VTE cases occurred in each group, respectively. The multivariable-adjusted HR was 0.65 (95% CI: 0.51, 0.84). The corresponding risks for pulmonary embolism (adjusted HR = 0.71, 95% CI: 0.50, 1.01) and deep vein thrombosis (adjusted HR = 0.64, 95% CI: 0.48, 0.87) were also lower in metformin initiators than in sulfonylurea initiators" - See metformin at ReliableRX.

SGLT2 Inhibitors Cut AFib Risk in Real-Word Analysis - Medscape, 6/14/22 - "But despite documentation like this, real-world evidence also continues to show limited uptake of SGLT2 inhibitors in U.S. patients with type 2 diabetes. Records from more than 1.3 million patients with type 2 diabetes managed in the Veterans Affairs Healthcare System during 2019 or 2022 documented that just 10% of these patients received an agent from this class, even though all were eligible to receive it, according to findings in a separate report at the meeting ... The study's primary endpoint was the incidence of hospitalization for AFib, which occurred a significant 18% less often in the patients who started on an SGLT2, compared with those who started a DPP4 inhibitor during median follow-up of 6.7 months, and a significant 10% less often, compared with those starting a GLP-1 receptor agonist during a median follow-up of 6.0 months ... in an analysis of more than 130,000 matched pairs, treatment with empagliflozin was linked to a significant 30% reduction in the incidence of hospitalization for heart failure, compared with patients treated with a GLP-1 receptor agonist. Analysis of more than 116,000 matched pairs of patients showed that treatment with empagliflozin linked with a significant 29%-50% reduced rate of hospitalization for heart failure, compared with matched patients treated with a DPP4 inhibitor" - See empagliflozin inhousepharmacy.vu.

Vitamin D deficiency can lead to dementia - Science Daily, 6/14/22 - "low levels of vitamin D were associated with lower brain volumes and an increased risk of dementia and stroke ... genetic analyses supported a causal effect of vitamin D deficiency and dementia ... in some populations as much as 17 per cent of dementia cases might be prevented by increasing everyone to normal levels of vitamin D (50 nmol/L)" - See vitamin D at Amazon.com.

FDA approves alopecia treatment - Hill. 6/14/22 - "more than 20 percent of patients who received 2 milligrams of Olumiant and more than a third of those who received 4 milligrams achieved 80 percent scalp hair coverage in 36 weeks, compared to only 5 percent who took the placebo"

Probiotic in the Prevention of Ventilator-Associated Pneumonia in Critically Ill Patients - Medscape, 6/15/22 -"Based on the results of our study, the current evidences suggested that prophylactic administration of probiotic might be utilized as a preventive method for VAP in neonates/children and adults patients who required mechanical ventilation" - See probiotic supplements at Amazon.com.

'Good' bacteria to tackle depression - Science Daily, 6/9/22 - "All participants were inpatients at the University Psychiatric Clinics Basel (UPK) and were given a probiotic (21 subjects) or a placebo (26 subjects) for 31 days, in addition to antidepressants ... although depressive symptoms decreased in all participants thanks to the general antidepressant treatment, there was a greater improvement in the subjects in the probiotic group than in the placebo group ... Another interesting effect of taking probiotics was seen in relation to brain activity when viewing neutral or fearful faces. The researchers investigated this effect using functional magnetic resonance imaging (fMRI). In patients with depression, certain brain regions for emotional processing behave differently than in individuals with good mental health. After four weeks of probiotics, this brain activity normalized in the probiotic group but not in the placebo group ... Although the microbiome-gut-brain axis has been the subject of research for a number of years, the exact mechanisms are yet to be fully clarified ... This was another reason why the researchers believed it was important to use a wide range of bacteria in the form of probiotics, such as formulations already available on the market" - See probiotic supplements at Amazon.com.

Omega-3 Fatty Acids May Reduce Blood Pressure - Medscape, 6/8/22 - "The meta-analysis was based on 71 randomized controlled trials that included 4973 participants ... The optimal intakes of omega-3 fatty acids associated with reductions in both systolic and diastolic blood pressure were seen with "moderate doses," they note, between 2 grams per day, associated with systolic blood pressure reductions of 2.61 mm Hg and 1.64 mm Hg diastolic, and 3 grams per day, with a systolic blood pressure reduction of 2.61 mm Hg and a diastolic blood pressure reduction of 1.69 mm Hg" - See omega-3 supplements at Amazon.com.

Rapamycin increases Alzheimer's-associated plaques in mice, study finds - Science Daily, 6/7/22 - "The study is relevant to β-amyloid-associated Alzheimer's and is not generalizable to other Alzheimer's pathologies ... Findings from this study may give the medical world a reason to pause testing rapamycin on anyone at risk of Alzheimer's disease. "Rapamycin may have benefits in terms of suppressing the immune system and as a tumor suppressor," Dr. Bhat said. "But in a situation where it negatively impacts the expression of Trem2 or other critical proteins, it may have a detrimental effect. We caution that rapamycin's benefits in β-amyloid-associated Alzheimer's must be studied more carefully.""

• Rapamycin prevents age-related brain vascular deterioration in rats - Science Daily, 11/6/19 - "In the study, published Nov. 6 in the journal Aging Cell, researchers began rats on a diet including low-dose rapamycin at 19 months old (past middle age in rat years). Rapamycin treatment in daily food continued until the mice were of advanced age -- 34 months old -- almost double the age they were when they started treatment. "Essentially this is as old as these rats can get. These animals were very old but still, blood circulation in the brain was exactly the same as when they started treatment," said study senior author Veronica Galvan, Ph.D., professor of cellular and integrative physiology at UT Health San Antonio"
• Research explains action of drug that may slow aging, related disease - Science Daily, 5/20/14 - "Laboratory mice that have received rapamycin have reduced the age-dependent decline in spontaneous activity, demonstrated more fitness, improved cognition and cardiovascular health, had less cancer and lived substantially longer than mice fed a normal diet"

Changing the channel: Study sheds new light on a promising antidepressant - Science Daily, 6/7/22 - "Even though depression is on the rise in developed countries, taking a heavy toll in terms of human suffering and economic loss, there have been no major breakthroughs in the treatment of depression since the 1987 approval of the most famous antidepressant of all time, Prozac. Meanwhile, existing drugs bring no relief to about a third of depressed patients. Even when the drugs do work, they take four to eight weeks to take effect, a delay that can prove fatal in suicidal cases. That's precisely the reason for much of the excitement over ketamine-based therapies: They make people feel better within hours. Their antidepressant action then lasts for days after the drug itself has cleared from the body. Evidently, it's the body's response to ketamine, rather than ketamine itself, that produces the desired effect, but the nature of this response has until now been unclear."

Cannabis products demonstrate short-term reduction in chronic pain, little else, review finds - Science Daily, 6/6/22 - "Evidence behind the effectiveness of cannabis-related products to treat chronic pain is surprisingly thin"

Dapagliflozin Early Benefit Explored in Reduced-EF Heart Failure - Medscape, 6/6/22 - "Functional capacity in heart failure with reduced ejection fraction (HFrEF) appears to improve within a few weeks of SGLT2-inhibitor initiation, suggests a small, randomized study that followed peak VO2 in patients with HFrEF assigned to take dapagliflozin (Farxiga). The benefit observed at 30 days held at a plateau for at least a few more months ... The new study, called DAPA-VO2 , has limitations but is consistent with a similar study of empagliflozin (Jardiance), investigators observed, and could help explain why clinical risk fell off so rapidly once patients started on SGLT2 inhibitors in major HFrEF trials of these drugs ... Peak VO2 in the study rose 8% further (P = .021) in patients on dapagliflozin compared with placebo a month into the trial, the gain persisting at least to 90 days" - See empagliflozin inhousepharmacy.vu.

Abstracts from this week:

Sacubitril-Valsartan Increases Ultrafiltration in Patients Undergoing Peritoneal Dialysis: A Short-Term Retrospective Self-Controlled Study - Front Med (Lausanne) 2022 Jun 3 - "There are few data about the effectiveness and safety of angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril-valsartan in end-stage renal disease (ESRD) patients undergoing peritoneal dialysis (PD). The present study was conducted to evaluate the association between sacubitril-valsartan treatment and peritoneal ultrafiltration (PUF) in PD patients ... After treated with sacubitril-valsartan, 30 patients (63.8%) had a significant increase of PUF [up to 150.4 (110.7, 232.1) ml per day], while the remaining 17 (36.2%) had a slight decrease. The overall increase of PUF was 66.4 (21.4, 123.2) ml/24 h within the 7 days after sacubitril-valsartan administration, which was significantly higher than those before (P = 0.004). Total output, BP, and body weight also significantly improved. No adverse drug reactions were observed"

Beneficial effect of L-Proline supplementation on the quality of human spermatozoa - Andrologia 2022 Jun 18 - "L-Proline is a natural anti-oxidative and osmoprotectant agent, playing a versatile role in cell metabolism and physiology. The present study aimed to explore the antioxidant effects of L-Proline on human sperm function during incubation. Thirty healthy, normozoospermic men (27-40 years) were enrolled. Sperm samples were incubated in an unsupplemented sperm medium (control group), or supplemented with L-Proline (1, 2 and 4 mmol/L) to evaluate its effect during 0, 1, 4 and 24 h of incubation ... The results indicated that 2 mmol/L of L-Proline significantly improved the maintenance of sperm motility, viability, normal morphology, chromatin and DNA integrity, and TAC levels compared to the control group during 24 h of incubation (p < 0.05). However, 1 and 4 mmol/L of L-Proline could not significantly preserve sperm parameters, chromatin quality, and antioxidant status during different incubation times compared to the control group (p > 0.05). Collectively, the inclusion of L-Proline (2 mmol/L) in the human sperm medium maintains sperm parameters and chromatin quality probably by modulating the oxidative status" - See L-Proline at Amazon.com.

Impact of dronedarone on patients with atrial fibrillation and diabetes: A sub-analysis of the ATHENA and EURIDIS/ADONIS studies - J Diabetes Complications 2022 Jun 8 - "Dronedarone reduced incidence of CV hospitalization/death, AF/AFL recurrence and increased time to these events in AF/AFL patients with/without diabetes" - Note: But why didn't they include amiodarone in addition to the placebo?

Long noncoding RNA-EN_181 potentially contributes to the protective effects of N-acetylcysteine against non-alcoholic fatty liver disease in mice - Br J Nutr 2022 Jun 17 - "N-acetylcysteine (NAC) possesses a strong capability to ameliorate high-fat diet (HFD)-induced nonalcoholic-fatty liver disease (NAFLD) in mice, but the underlying mechanism is still unknown ... Overall, lncRNA-EN_181 might be a potential target in NAC-ameliorated NAFLD. This finding enhanced our understanding of the biological mechanisms underlying the beneficial role of NAC." - See n-acetyl cysteine at Amazon.com.

Curcumin Improved Intestinal Epithelial Barrier Integrity by Up-Regulating ZO-1/Occludin/Claudin-1 in Septic Rats - Evid Based Complement Alternat Med 2022 Jun 7 - "To investigate the protective effect and mechanism of curcumin on intestinal barrier function in rats with enterogenic sepsis ... Curcumin can reduce inflammatory response and upregulate the expression of intestinal tight junction proteins ZO-1, occludin, and claudin-1 in rats with enterogenic sepsis, and protect intestinal barrier function" - See curcumin at Amazon.com.

Neuroprotective effects of Canagliflozin: Lessons from aged genetically diverse UM-HET3 mice - Aging Cell 2022 Jun 15 - "The aging brain is characterized by progressive increases in neuroinflammation and central insulin resistance, which contribute to neurodegenerative diseases and cognitive impairment. Recently, the Interventions Testing Program demonstrated that the anti-diabetes drug, Canagliflozin (Cana), a sodium-glucose transporter 2 inhibitor, led to lower fasting glucose and improved glucose tolerance in both sexes, but extended median lifespan by 14% in male mice only. Here, we show that Cana treatment significantly improved central insulin sensitivity in the hypothalamus and the hippocampus of 30-month-old male mice. Aged males produce more robust neuroimmune responses than aged females. Remarkably, Cana-treated male and female mice showed significant reductions in age-associated hypothalamic gliosis with a decrease in inflammatory cytokine production by microglia ... Thus, Cana treatment improved insulin responsiveness in aged male mice. Furthermore, Cana treatment improved exploratory and locomotor activity of 30-month-old male but not female mice. Taken together, we demonstrate the sex-specific neuroprotective effects of Cana treatment, suggesting its application for the potential treatment of neurodegenerative diseases" - See canagliflozin at ReliableRXPharmacy.

SGLT2 inhibitor dapagliflozin attenuates cardiac fibrosis and inflammation by reverting the HIF-2α signaling pathway in arrhythmogenic cardiomyopathy - FASEB J 2022 Jul - "Excessive cardiac fibrosis and inflammation aberrantly contribute to the progressive pathogenesis of arrhythmogenic cardiomyopathy (ACM) ... dapagliflozin (DAPA ... DAPA not only significantly ameliorated cardiac dysfunction, adverse remodeling, and ventricular dilation in ACM but also attenuated ACM-associated cardiac fibrofatty replacement, as demonstrated by the echocardiography and histopathological examination ... SGLT2i attenuated the ACM-associated cardiac dysfunction and adverse remodeling in a glucose-independent manner by suppressing cardiac fibrosis and inflammation via reverting the HIF-2α signaling pathway, suggesting that SGLT2i is a novel and available therapy for ACM" - See dapagliflozin at reliablerxpharmacy.com.

• Arrhythmogenic cardiomyopathy - Wikipedia - "Arrhythmogenic cardiomyopathy (ACM), arrhythmogenic right ventricular dysplasia (ARVD), or arrhythmogenic right ventricular cardiomyopathy (ARVC), most commonly is an inherited heart disease ... ACM is caused by genetic defects of the parts of heart muscle (also called myocardium or cardiac muscle) known as desmosomes, areas on the surface of heart muscle cells which link the cells together. The desmosomes are composed of several proteins, and many of those proteins can have harmful mutations ... ARVC can also develop in intense endurance athletes in the absence of desmosomal abnormalities. Exercise-induced ARVC cause possibly is a result of excessive right ventricular wall stress during high intensity exercise"

Effects of whey and soy protein supplementation on inflammatory cytokines in older adults: a systematic review and meta-analysis - Br J Nutr 2022 Jun 16 - "These data support that whey and soy protein supplementation elicit anti-inflammatory effects by reducing circulating IL-6 and TNF-a levels, respectively. This effect may be enhanced by soy isoflavones and may be more prominent in individuals with sarcopenia" - See whey protein at Amazon.com and Soy isoflavones at Amazon.com.

Trigonella foenum-graecum L. and Psoralea corylifolia L. Improve Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats through Suppression of Oxidative Stress - Evid Based Complement Alternat Med 2022 Jun 6 - "Diabetes mellitus-induced erectile dysfunction (DMED) is one of the most common complications of diabetes and is mainly attributed to oxidative stress. Hu-Lu-Ba-Wan (HLBW) is a classic Chinese formulation consisting of Trigonella foenum-graecum L. (TFG) and Psoralea corylifolia L. (PC). HLBW has been used not only for the treatment of diabetes but also for the treatment of erectile dysfunction in clinics ... The results showed that HLBW significantly reduced blood glucose and increased insulin sensitivity. HLBW reduced oxidative stress and apoptosis. In addition, we observed that the expression levels of vWF, α-SMA, and eNOS as well as the ratio of smooth muscle to collagen increased in the HLBW group"

• Psoralea corylifolia Linn. - NIH - "Psoralea corylifolia, commonly known as babchi, is a popular herb, which has since long been used in traditional Ayurvedic and Chinese medicine for its magical effects to cure various skin diseases. This plant is also pharmacologically studied for its chemoprotective, antioxidant, antimicrobial, and antiinflammatory properties" - See Trigonella foenum-graecum at Amazon.com and babchi at Amazon.com.

Ursolic acid inhibits the activation of smoothened-independent non-canonical hedgehog pathway in colorectal cancer by suppressing AKT signaling cascade - Phytother Res 2022 Jun 16 - "Ursolic acid (UA), a pentacyclic triterpenoid present in many medicinal herbs, manifests potent effectiveness against multiple malignancies including colorectal cancer (CRC) ... Taken together, UA may alleviate CRC by suppressing AKT signaling-dependent activation of SMO-independent non-canonical Hedgehog pathway" - See ursolic acid at Amazon.com.

The role of functional oligosaccharides as prebiotics in ulcerative colitis - Food Funct 2022 Jun 15 - "The current studies on UC implicate a strong correlation between host gut microbiota immunity and the pathogenesis of UC. Meanwhile, more and more functional oligosaccharides have been reported as prebiotics to alleviate UC, since many of them can be metabolized by gut microbiota to produce short-chain fatty acids (SCFAs). The present review is focused on the structure, sources and specific applications of various functional oligosaccharides related to the prevention and treatment of UC" - See inulin at Amazon.com.

The Association between Dietary Vitamin C Intake and the Risk of Esophageal Cancer: An Updated Dose-Response Meta-Analysis - Nutr Cancer 2022 Jun 15 - "dietary vitamin C intake was negatively correlated to the risk of esophageal cancer. The analysis of subgroup showed a significant counter proportion between vitamin C and the risk of ESCC and EAC. Moreover, the dose-analysis indicated that if increasing dietary intake of vitamin C of 50 mg/day, esophageal cancer risk dropped down 10% (OR = 0.81, 95%CI: 0.75-0.87). In summary, our study provides a comprehensive and updated epidemiological evidence to elucidate the relationships between dietary vitamin C and reduction of esophageal cancer risk" - See vitamin C products at Amazon.com.

Association between plasma Vitamin B5 levels and all-cause mortality: A nested case-control study - J Clin Hypertens (Greenwich) 2022 Jun 14 - "When vitamin B5 was further assessed as quintiles, compared with the reference group (Q1: < 33.0 ng/mL), the risk of all-cause mortality increased by 29% (OR = 1.29, 95% CI: 0.83-2.01) in Q2, 22% (OR = 1.22, 95% CI: 0.77-1.94) in Q3, 62% (OR = 1.62, 95% CI: 1.00-2.62) in Q4, and 77% (OR = 1.77, 95% CI: 1.06-2.95) in Q5. The trend test was significant (p = .022). When Q4-Q5 were combined, a significant 41% increment (OR = 1.41, 95% CI: 1.03-1.95) in all-cause death risk was found compared with Q1-Q3. The adverse effects were more pronounced in those with normal folate levels (p-interaction = .019) and older people (p-interaction = .037). This study suggests that higher baseline levels of plasma vitamin B5 are a risk factor for all-cause mortality among Chinese patients with hypertension, especially among older adults and those with adequate folate levels"

Metformin Use and Mortality in Women with Ovarian Cancer: An Updated Meta-Analysis - Int J Clin Pract 2022 Feb 28 - "Nine studies including 10030 women with OC were included. Overall, metformin use was independently associated with reduced overall mortality (hazard ratio (HR): 0.72" - See metformin at ReliableRX.

 Protective Effect of Silymarin and Gallic Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity - Int J Clin Pract 2022 Apr 16 - "it was observed that gallic acid silymarin had a protective effect on cisplatin-induced nephrotoxic and hepatotoxic effects" - See silymarin at Amazon.com.

Efficacy of Adjuvant Tamsulosin for Improving the Stone-Free Rate after Extracorporeal Shock Wave Lithotripsy in Renal Stones: A Randomized Controlled Trial - Int J Clin Pract 2022 Jan 31 - "Our findings suggest that tamsulosin as adjuvant treatment after a single ESWL session is well tolerated and safe, but it does not increase the stone-free rate in patients with a single radiopaque renal stone of 5-20 mm in diameter. Our results may support the use of tamsulosin with ESWL in the case of patients with a single radiopaque renal stone of 11-20 mm in diameter based on an apparent higher stone-free rate and a low rate of complications."

The influence of the macular carotenoids on women's eye and brain health - Nutr Neurosci 2022 Jun 11 - "Dietary intake of the pigmented carotenoids appears to be particularly important for issues such as visual and cognitive loss. This may be due to the highly selective presence of a fraction of carotenoids, namely lutein (L) and zeaxanthin (Z), in specific tissues of the eye and brain. At those sites, L and Z have been shown to directly improve function and prevent central nervous system degeneration. On the palliative side, retinal LZ reduce glare disability, discomfort and photostress, improve chromatic contrast and visual range (e.g., the ability to see through blue atmospheric haze). These effects on input reflect changes in neural output such as improved visual processing speed, problem solving, memory and executive function (presumably due, also, to local effects in areas such as the hippocampus and frontal cortex). These effects on function throughout the central nervous system are mirrored by effects on disease progression. As potent antioxidants/anti-inflammatory agents, and "blue-blockers" within the retina, the pigments prevent loss that precedes neurodegenerative diseases such as age-related macular degeneration and some forms of dementia." - See mixed carotenoids at Amazon.com.

Anti-Photoaging Effect of Rhodiola rosea Fermented by Lactobacillus plantarum on UVA-Damaged Fibroblasts - Nutrients 2022 Jun 1 - "UVA can cause oxidative stress and photoaging of cells. We established a UVA-induced oxidative stress model of human fibroblasts and focused on the antioxidant and anti-photoaging ability of Lactobacillus plantarum fermented Rhodiola rosea. Compared with the unfermented Rhodiola rosea, Lactobacillus plantarum fermented Rhodiola rosea has better DPPH free radical and hydroxyl free radical scavenging ability, significantly reduces the content of reactive oxygen species (ROS), and improves the antioxidant level. Further studies have shown that the Lactobacillus plantarum fermented Rhodiola rosea can activate the Nrf2/Keap1 signaling pathway and up-regulate heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO1), catalase (CAT) and glutathione Peptide peroxidase (GSH-Px), and protect fibroblasts from oxidative stress caused by UVA. On the other hand, Lactobacillus plantarum fermented Rhodiola rosea significantly reduces the activity of metalloproteinases in the cell, thereby increasing the collagen and elastin in the cell, alleviating the photoaging caused by UVA. Finally, we concluded that the antioxidant capacity and anti-photoaging ability of Lactobacillus plantarum fermented Rhodiola rosea are better than that of unfermented Rhodiola rosea" - See fermented Rhodiola rosea (It doesn't show any fermented. Google shows several studies on fermented but none for sale).

Associations of Vitamin B6 Intake and Plasma Pyridoxal 5'-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003-2004 - Nutrients 2022 Jun 2 - "Adequate B6 status was associated with high EPA and EPA/AA status. These findings suggest that sufficient vitamin B6 status may positively influence PUFA metabolism in older adults" - See vitamin B6 at Amazon.com.

11β-HSD1 Inhibitor Alleviates Non-Alcoholic Fatty Liver Disease by Activating the AMPK/SIRT1 Signaling Pathway - Nutrients 2022 Jun 6 - "We investigated the effect of an 11β-HSD1 inhibitor (H8) on hepatic steatosis and its mechanism of action. Although H8, a curcumin derivative, has been shown to alleviate insulin resistance, its effect on non-alcoholic fatty liver disease (NAFLD) remains unknown ... Our findings demonstrate that H8 alleviates hepatic steatosis, by inhibiting 11β-HSD1, which activates the AMPK/SIRT1 signaling pathway" - See curcumin at Amazon.com.

Effects of Five Amino Acids (Serine, Alanine, Glutamate, Aspartate, and Tyrosine) on Mental Health in Healthy Office Workers: A Randomized, Double-Blind, Placebo-Controlled Exploratory Trial -Nutrients 2022 Jun 6 - "The importance of maintaining good mental health with overall well-being has recently drawn attention from various spheres of academics and the working population. Amino acid intake has been reported to reduce depression symptoms and other mental health problems. However, the effectiveness of amino acid intake (i.e., single or combined) remains unknown. In this study, we assessed a combination of five amino acids (serine, alanine, glutamate, aspartate, and tyrosine; SAGAT) reported to regulate mental health ... The current findings suggest that SAGAT contributes to maintaining proper motivation and cognitive function" - See serine at Amazon.com, beta-alanine at Amazon.com, glutamate supplements at Amazon.com, aspartate supplements at Amazon.com, and n-acetyl tyrosine at Amazon.com.

New Mechanisms of Bromelain in Alleviating Non-Alcoholic Fatty Liver Disease-Induced Deregulation of Blood Coagulation - Nutrients 2022 Jun 1 - "Bromelain, an enzyme extracted from the stems of pineapples, exerts anticoagulant effects; however, the regulatory mechanisms are not fully understood ... these findings suggest that bromelain exerts anticoagulant effects on NAFLD-induced deregulation of coagulation by inhibiting the activation of the coagulation cascade, decreasing the stability of clots, and promoting fibrinolytic activity. The present study provides new insights into the potential therapeutic value of bromelain for the prevention and treatment of thrombosis-related diseases" - See bromelain at Amazon.com.

Associations of plasma omega-3 and omega-6 pufa levels with arterial elasticity: the multi-ethnic study of atherosclerosis - Eur J Clin Nutr 2022 Jun 9 - "We investigated the association of circulating ω-3and ω-6 PUFAs with large artery elasticity (LAE) and small artery elasticity (SAE) in participants from the Multi-Ethnic Study of Atherosclerosis (MESA) ... In a multi-ethnic cohort of individuals free of baseline cardiovascular disease, higher plasma levels of total and individual ω-3 PUFAs were associated with an increased LAE" -  See omega-3 supplements at Amazon.com.

Metformin Promotes Mechanical Stretch-Induced Skin Regeneration by Improving the Proliferative Activity of Skin-Derived Stem Cells - Front Med (Lausanne) 2022 May 24 - "Skin expansion by mechanical stretch is an essential and widely used treatment for tissue defects in plastic and reconstructive surgery; however, the regenerative capacity of mechanically stretched skin limits clinical treatment results. Here, we propose a strategy to enhance the regenerative ability of mechanically stretched skin by topical application of metformin ... Compared with the control group, metformin treatment was beneficial to mechanical stretch-induced skin regeneration by increasing the thicknesses of epidermis (57.27 ± 10.24 vs. 31.07 ± 9.06 μm, p < 0.01) and dermis (620.2 ± 86.17 vs. 402.1 ± 22.46 μm, p < 0.01), number of blood vessels (38.30 ± 6.90 vs. 17.00 ± 3.10, p < 0.01), dermal collagen volume fraction (60.48 ± 4.47% vs. 41.28 ± 4.14%, p < 0.01), and number of PCNA+, Aurora B+, and pH3+ cells. Additionally, we observed significant elevations in the number of proliferating hair follicle bulge stem cells [cytokeratin (CK)15+/proliferating cell nuclear antigen (PCNA)+] (193.40 ± 35.31 vs. 98.25 ± 23.47, p < 0.01) and epidermal stem cells (CK14+/PCNA+) (83.00 ± 2.38 vs. 36.38 ± 8.96, p < 0.01) in the metformin-treated group, and western blot results confirmed significant increases in CK14 and CK15 expression following metformin treatment" - See metformin at ReliableRX.

ZhenQi FuZheng formula inhibits the growth of colorectal tumors by modulating intestinal microflora-mediated immune function - Aging (Albany NY) 2022 Jun 8 - "Zhenqi Fuzheng formula (ZQFZ), of which the main ingredients are Astragalus membranaceus and Ligustrum lucidum, has immune system regulatory functions and potential anti-tumor bioactivity ... ZQFZ promoted an anti-tumor immune response and inhibited the occurrence and development of CRC by regulating the immune system. This study provides the experimental basis for the application of ZQFZ as a therapeutic agent for CRC" - See Astragalus membranaceus at Amazon.com and Ligustrum lucidum at Amazon.com.

Antioxidative Stress and Anti-Inflammatory Activity of Fucoidan Nanoparticles against Nephropathy of Streptozotocin-Induced Diabetes in Rats - Evid Based Complement Alternat Med 2022 May 31 - "Oxidative stress and inflammation have been shown to interact and have the role of importance in causing diabetic nephropathy complications. Fucoidan has a strong antioxidant and anti-inflammation effect, so the aim of this research was to evaluate the antioxidative stress and anti-inflammatory effect of fucoidan nanoparticles against nephropathy of streptozotocin-induced diabetes in rats ... fucoidan nanoparticles are promising agents in terms of the protection afforded against streptozotocin-induced nephropathy through antioxidative stress by decreasing MDA and increasing SOD and GPx and through anti-inflammatory effect by decreasing levels of IL-6 and TNF-α."

• Fucoidan - Wikipedia - "Fucoidan is a long chain sulfated polysaccharide found in various species of brown algae. Commercially available fucoidan is commonly extracted from the seaweed species Fucus vesiculosus, Cladosiphon okamuranus, Laminaria japonica and Undaria pinnatifida" - See fucoidan at Amazon.com.

Kaempferol antagonizes adipogenesis by repressing histone H3K4 methylation at PPARγ target genes - Biochem Biophys Res Commun 2022 Jun 1 - "We previously demonstrated that kaempferol, a flavonoid present in various herbs, inhibits adipogenesis by repressing peroxisome proliferator-activated receptor γ (PPARγ) activity ... Overall, our data suggest that kaempferol, as a PPARγ antagonist, mediates epigenetic repression of lipid accumulation by regulating histone methylation, and could serve as a candidate epigenetic drug to treat obesity-related diseases" - See Kaempferia parviflora at Amazon.com.

Nicotinamide mononucleotide supplementation protects the intestinal function in aging mice and D-galactose induced senescent cells - Food Funct 2022 Jun 9 - "The nicotinamide adenine dinucleotide (NAD+) level shows a temporal decrease during the aging process, which has been deemed as an aging hallmark. Nicotinamide mononucleotide (NMN), a key NAD+ precursor, shows the potential to retard the age-associated functional decline in organs ... The above data demonstrated the potential of NMN in ameliorating the structural and functional decline in the intestine during aging" - See nicotinamide mononucleotide at Amazon.com.

Effects of Resveratrol on Metabolic Indicators in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis - Int J Clin Pract 2022 Jan 31 - "Compared with the control data, large doses of resveratrol (≥1000 mg) reduced fasting blood glucose levels (WMD: -18.76 mg/dL, 95% CI: -23.43, -14.09; P < 0.00001). Additionally, resveratrol reduced systolic blood pressure (WMD: -7.97 mmHg, 95% CI: -10.63, -5.31; P < 0.00001) and diastolic blood pressure (WMD: -3.55 mmHg, 95% CI: -5.18, -1.93; P < 0.00001) in patients with type 2 diabetes but did not improve waist circumference (WMD: 0.05 cm, 95% CI: -1.77, 1.88; P=0.95), triglyceride levels (WMD: -4.49 mg/dL, 95% CI: -24.23, 15.25; P=0.66), or high-density lipoprotein cholesterol levels (WMD: -1.05 mg/dL, 95% CI: -2.44, 0.33; P=0.14) in patients with type 2 diabetes" - See resveratrol products at Amazon.com.

Resveratrol attenuates behavioural impairment associated with learning and memory in HFD-STZ induced diabetic rats - Br J Pharmacol 2022 Jun 16 - "Literature have indicated that a high-fat diet (HFD) is a common risk factor for type 2 diabetes mellitus (T2DM) and its associated cognitive-impairments. Mounting evidence supports that, in the diabetic animal model, resveratrol (RSV, SIRT1-modulator) can regulate the fasting glucose and antioxidant levels, as well as the lipid profile, and may alleviate the cognitive-dysfunction associated with diabetes ... Our investigations demonstrate that SIRT1-modulation can inter-play with TGF-β1 signalling, as well as mitigate hyperglycaemia and subsequent learning-memory impairments, in the T2DM-animals. Moreover, our study showed that novel therapeutic-targets, including TGF-β1, may add to our knowledge of RSV when used in the treatment of impaired memory-associated with diabetes" - See resveratrol products at Amazon.com.

Combination of resveratrol and luteolin ameliorates α-naphthylisothiocyanate-induced cholestasis by regulating the bile acid homeostasis and suppressing oxidative stress - Food Funct 2022 Jun 14 - "Cholestasis is a common liver injury without any effective therapeutic drugs so far. Resveratrol (RES) and luteolin (LUT) are natural polyphenols that exert protective effects on multiple liver injurieshis study suggested that the coadministration of RES and LUT could protect against ANIT-induced cholestasis and the mechanism was closely related to regulating BA homeostasis and suppressing oxidative stress" - See resveratrol products at Amazon.com and luteolin products at Amazon.com.

Panax notoginseng Alleviates Sepsis-Induced Acute Kidney Injury by Reducing Inflammation in Rats - Evid Based Complement Alternat Med 2022 May 21 - "Sepsis is defined as a host inflammatory response to infection that can result in end-organ dysfunction. One of the most common consequences of sepsis is acute kidney injury (AKI). Panax notoginseng powder (PNP) has been previously reported to protect against overactive inflammation process ... PNP attenuated kidney inflammation to protect against CLP-induced septic AKI in rats via inhibiting the NF-κB signaling pathway" - See Panax ginseng at Amazon.com.

Ginsenoside Rh4 Inhibits Colorectal Cancer Cell Proliferation by Inducing Ferroptosis via Autophagy Activation - Evid Based Complement Alternat Med 2022 May 29 - "Colorectal cancer (CRC) is a severe threat to human health. Ginsenosides such as ginsenoside Rh4 have been widely studied in the antitumor field ... this study proves that Rh4 inhibits cancer cell proliferation by activating the ROS/p53 signaling pathway and activating autophagy to induce ferroptosis, which provides necessary scientific evidence of the great anticancer potential of Rh4" - See ginseng at Amazon.com.

Dairy foods, calcium intakes, and risk of incident prostate cancer in Adventist Health Study-2 - Am J Clin Nutr 2022 Jun 8 - "Men with higher intake of dairy foods, but not nondairy calcium, had a higher risk of prostate cancer compared with men having lower intakes. Associations were nonlinear, suggesting greatest increases in risk at relatively low doses"

Rosmarinic Acid Inhibits Platelet Aggregation and Neointimal Hyperplasia In Vivo and Vascular Smooth Muscle Cell Dedifferentiation, Proliferation, and Migration In Vitro via Activation of the Keap1-Nrf2-ARE Antioxidant System - J Agric Food Chem 2022 Jun 10 - "The activation of platelets and proliferation of vascular smooth muscle cells (VSMCs) in the vascular intima play an essential role in the pathological mechanism of vascular restenosis (RS). Rosmarinic acid (RA) is a natural phenolic acid compound ... these results indicate that RA inhibits platelet function and attenuates the proliferation, migration, and phenotypic transition of VSMCs induced by PDGF-BB in vitro and vascular remodeling in vivo. Therefore, RA treatment may be a potential therapy for preventing or treating RS" -  See rosemary extract at Amazon.com.

Rosmarinic acid ameliorated psoriatic skin inflammation in mice through the novel inhibition of the interleukin-17A/interleukin-17A receptor interaction - Food Funct 2022 Jun 8 - "this is the first study reporting that rosmarinic acid is an IL-17A-targeting agent that ameliorates psoriatic skin inflammation in mice via blocking the IL-17A/IL-17RA interaction" - See rosemary extract at Amazon.com.

Exercise increases the release of NAMPT in extracellular vesicles and alters NAD + activity in recipient cells - Aging Cell 2022 Jun 3 - "Aging is associated with a loss of metabolic homeostasis, with cofactors such as nicotinamide adenine dinucleotide (NAD+ ) declining over time. The decrease in NAD+ production has been linked to the age-related loss of circulating extracellular nicotinamide phosphoribosyltransferase (eNAMPT), the rate-limiting enzyme in the NAD+ biosynthetic pathway. eNAMPT is found almost exclusively in extracellular vesicles (EVs), providing a mechanism for the distribution of the enzyme in different tissues ... Here, we show that release of small EVs into the bloodstream is stimulated following moderate intensity exercise in humans. Exercise also increased the eNAMPT content in EVs, most prominently in young individuals with higher aerobic fitness. Both mature fit and young unfit individuals exhibited a limited increase in EV-eNAMPT release following exercise, indicating that this mechanism is related to both the age and physical fitness of a person. Notably, unfit mature individuals were unable to increase the release of eNAMPT in EVs after exercise, suggesting that lower fitness levels and aging attenuate this important signalling mechanism in the body. EVs isolated from exercising humans containing eNAMPT were able to alter the abundance of NAD+ and SIRT1 activity in recipient cells compared to pre-exercise EVs, indicating a pathway for inter-tissue signalling promoted through exercise. Our results suggest a mechanism to limit age-related NAD+ decline, through the systemic delivery of eNAMPT via EVs released during exercise"

Comparative efficacy of novel antidiabetic drugs on cardiovascular and renal outcomes in patients with diabetic kidney disease: A systematic review and network meta-analysis - Diabetes Obes Metab 2022 Jun 6 - "A clear advantage was demonstrated by SGLT2 inhibitors in reducing the risks of CV and renal events in patients with DKD, compared to GLP-1RAs and DPP-4 inhibitors. We recommend that SGLT2 inhibitors be considered the treatment of choice in patients with DKD" - See empagliflozin inhousepharmacy.vu.

SGLT2 Inhibition via Empagliflozin Improves Endothelial Function and Reduces Mitochondrial Oxidative Stress: Insights From Frail Hypertensive and Diabetic Patients - Hypertension 2022 Jun 15 - "Frailty is a multidimensional condition often diagnosed in older adults with hypertension and diabetes, and both these conditions are associated with endothelial dysfunction and oxidative stress ... Taken together, our data indicate that empagliflozin reduces frailty in diabetic and hypertensive patients, most likely by decreasing mitochondrial reactive oxygen species production in endothelial cells" - See empagliflozin inhousepharmacy.vu.

Effects of vitamin D supplementation during pregnancy on offspring health at birth: A meta-analysis of randomized controlled trails - Clin Nutr 2022 May 17 - "Vitamin D supplementation during pregnancy was associated with improved offspring vitamin D sufficiency status, improved fetal linear growth, and reduced fetal or neonatal mortality. No effect was demonstrated for vitamin D supplementation on birth weight, risk of low birth weight, and risk of preterm birth" - See vitamin D at Amazon.com.

The relationship between dietary selenium intake and telomere length among diabetes - Br J Nutr 2022 Jun 10 - "After controlling for the confounders, 1 μg increase in dietary selenium intake in female patients with diabetes, and telomere length increased by 1.84 base pairs (β = 1.84 [95% confidence interval (CI): 0.15, 3.53]). There was a line relationship between dietary selenium intake and telomere length in female patients with diabetes, and telomere length increased with increasing dietary selenium intake within the range of 0-250 μg" - See se-methyl l-selenocysteine at Amazon.com.

Prevalence of micronutrient deficiency and its impact on the outcome of childhood cancer: A prospective cohort study - Clin Nutr 2022 May 18 - "Selenium deficiency was independently predictive of adverse outcomes in childhood cancer, particularly in haematological malignancies. Zinc deficiency adversely affected solid tumours" - See se-methyl l-selenocysteine at Amazon.com and zinc supplements at Amazon.com.

Relationship between the consumption of wholegrain and nonalcoholic fatty liver disease: The TCLSIH cohort study - Clin Nutr 2022 May 18 - "After adjusting for several potential confounders and setting "almost never" as the control group, the multivariable hazard ratios (95% confidence intervals) of the NAFLD were 0.82 (0.73, 0.92) when they consuming ≤1 time/week, 0.78 (0.69, 0.88) when they consuming 2-6 time/week and 0.77 (0.66, 0.90) when they consuming ≥1 time/day (p for trend" - See brown rice pasta at Amazon.com.

Combination of resveratrol and luteolin ameliorates α-naphthylisothiocyanate-induced cholestasis by regulating the bile acid homeostasis and suppressing oxidative stress - Food Funct 2022 Jun 14 - "Cholestasis is a common liver injury without any effective therapeutic drugs so far. Resveratrol (RES) and luteolin (LUT) are natural polyphenols that exert protective effects on multiple liver injurieshis study suggested that the coadministration of RES and LUT could protect against ANIT-induced cholestasis and the mechanism was closely related to regulating BA homeostasis and suppressing oxidative stress" - See resveratrol products at Amazon.com and luteolin products at Amazon.com.

Ameliorative Potential of Resveratrol in Dry Eye Disease by Restoring Mitochondrial Function - Evid Based Complement Alternat Med 2022 May 26 -0 "In the DED mouse model, resveratrol treatment promoted tear production and goblet cell number in DED mice, decreased corneal fluorescein staining, upregulated SIRT1 expression, and induced SOD2 and GPx expression in DED mice ... Resveratrol alleviates mitochondrial dysfunction by promoting SIRT1 expression, thus reducing ocular surface injury in mice with dry eye. This study suggests a new path against DED” - See resveratrol products at Amazon.com.

Effects of Collagen Peptide Supplementation on Cardiovascular Markers: A Systematic Review and Meta-analysis of Randomized, Placebo-Controlled Trials - Br J Nutr 2022 Jun 6 - "Previous studies have advocated that collagen peptide supplementation (CPS) can positively affect cardiovascular health ... Pooled data revealed that CPS significantly decreased fat mass (-1.21 kg; 95% CI: -2.13, -0.29; I2 = 0.0%; p = 0.010), and increased fat-free mass, based on body mass percentage (1.49 %; 95% CI: 0.57, 2.42; I2= 0.0%; p = 0.002). Moreover, collagen peptide supplementation led to a significant decrease in serum low-density lipoprotein (-4.09 mg/dl; 95% CI: -8.13, -0.04; I2 = 93.4%; p = 0.048) and systolic blood pressure (-5.04 mmHg; 95 % CI: -9.22, -0.85; I2 = 98.9%; p = 0.018). Our analysis also indicated that CPS did not affect glycemic markers. Our outcomes indicate that CPS reduces fat mass, low-density lipoprotein, and systolic blood pressure while increasing fat-free mass. Future investigations with longer CPS duration are needed to expand on our results" - See collagen supplements at Amazon.com.

Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review - J Bone Miner Metab 2022 Jun 16 - "This meta-analysis and systematic review seemed to support the hypothesis that vitamin K2 plays an important role in the maintenance and improvement of BMD, and it decreases uc-OC and increases OC significantly at a long-term follow-up. Vitamin K2 supplementation is beneficial and safe in the treatment of osteoporosis for postmenopausal women" - See vitamin k2 at Amazon.com.

Inverse association between plasma phylloquinone and risk of ischemic stroke in Chinese adults with hypertension and high body mass index: a nested case-control study - J Nutr 2022 Jun 6 - "In Chinese patients with hypertension, there was an inverse association between baseline plasma phylloquinone and risk of first ischemic stroke among those with higher BMI" - Note: People take vitamin k antagonists such as Warfarin to prevent strokes. I'm not a doctor but it sounds like they could also be contributing to strokes by reducing plasma vitamin K.

• Phytomenadione - Wikipedia - "Phytomenadione, also known as vitamin K1 or phylloquinone, is a vitamin found in food and used as a dietary supplement."  - See vitamin K at Amazon.com.

A prolonged bout of running increases hepcidin and decreases dietary iron absorption in trained female and male runners - J Nutr 2022 Jun 6 - "Declines in iron status are frequently reported in those who regularly engage in strenuous physical activity. A possible reason for the declines in iron status with physical activity is increases in the iron regulatory hormone hepcidin, which functions to inhibit dietary iron absorption and can be induced by the inflammatory cytokine interleukin-6 (IL-6) ... A prolonged bout of running increases hepcidin and decreases dietary iron absorption compared to rest in trained runners with low iron stores. The current study supports that IL-6 contributes to the increase in hepcidin with prolonged physical activity, though future studies should explore potential sex differences in the hepcidin response" - See iron supplements at Amazon.com.

Dr. Campbell still at it with his conspiracy theories and snake-oil.  60,000 views in two hours. Why people prefer BS is beyond me. You can even see the dishonesty in his face: Going by the number of views, he's making at least six figures per year, probably seven and he's full of shit.

Low scam awareness in old age may be an early sign of impending cognitive decline and dementia - Science Daily, 4/15/19 - "Older adults frequently are targeted by con-artists and are highly vulnerable to scams and fraud, particularly those that are financial in nature. However, little is known about whether scam awareness predicts transitions from normality to mild cognitive impairment and dementia ... low scam awareness was a harbinger of adverse cognitive outcomes. Low scam awareness was also associated with Alzheimer disease pathology in the brain. According to the researchers, these findings suggest that low scam awareness is an early sign of impending mild cognitive impairment and dementia. Further, they conclude that evaluation of behaviors such as scam awareness may help to identify individuals at risk for dementia before cognitive symptoms manifest."

Why older adults become fraud victims more often - Science Daily, 12/3/12 - "an important clue may lie in a particular region of the brain that influences the ability to discern who is honest and who is trying to deceive us ... Older people, more than younger adults, may fail to interpret an untrustworthy face as potentially dishonest ... a brain region called the anterior insula, which is linked to disgust and is important for discerning untrustworthy faces, is less active in older adults"

Health Focus (Periodontal Disease):