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Curcumin/Turmeric (Curcuma longa)

Related Topics:

• cancer cures? / inflammation

Specific Recommendations:

• Curcumin at Amazon.com
• nano-curcumin at Amazon.com
• Turmeric extract at Amazon.com
• Theracumin® curcumin at Amazon.com
• CurcuWIN® at Amazon.com
• CurQfen at Amazon.com

News & Research:

• Several Supplements May Give the Heart a Boost - WebMD, 12/8/22 - "Omega-3 fatty acids, found in fish, vegetable oils, nuts (especially walnuts), flax seeds, flaxseed oil, and leafy vegetables ... Omega-6 fatty acids, polyunsaturated fats found in vegetable oils, nuts, and seeds ... L-arginine, an amino acid that helps the body build protein. It can be found in protein-rich foods like fish, red meat, poultry, soy, whole grains, beans, and dairy products ... L-citrulline, a nonessential amino acid found in watermelon ... Folic acid, a form of vitamin B9 used for deficiency and to prevent pregnancy complications. It is added to cold cereals, flour, breads, pasta, bakery items, cookies, and crackers, as required by federal law. Foods that are naturally high in folate include leafy vegetables, okra, asparagus, certain fruits, beans, yeast, mushrooms, animal liver and kidney, orange juice, and tomato juice ... Vitamin D, a fat-soluble vitamin that is naturally present in a few foods, added to others, and available as a dietary supplement. Fatty fish (such as trout, salmon, tuna, and mackerel) and fish liver oils are among the best sources ... Magnesium, which keeps blood pressure normal, bones strong, and your heart rhythm steady. In addition to supplements, magnesium can be found in green leafy vegetables like spinach, nuts, beans, peas, and soybeans, as well as whole-grain cereals ... Zinc, found in chicken, red meat, and fortified breakfast cereals ... Alpha-lipoic acid, an antioxidant made naturally in the body and also found in foods. It is in red meat, carrots, beets, spinach, broccoli, and potatoes ... Coenzyme Q10, an antioxidant found in cold-water fish like tuna, salmon, mackerel, and sardines; vegetable oils; and meats ... Melatonin ... Plant-based polyphenols such as catechin, curcumin, flavanol, genistein, and quercetin"
• Randomized, Placebo Controlled, Double Blinded Pilot Superiority Phase 2 Trial to Evaluate the Effect of Curcumin in Moderate to Severe Asthmatics - Medscape, 10/7/21 - "With the onset of the COVID-19 pandemic, asthmatics have become even more vulnerable and have been found to be especially susceptible to more severe COVID-19 infections. As a result, this study has not been able to take place as was previously scheduled due to on-going safety concerns regarding the initial encounter because patients will need to be seen in clinic rather than via telecommunications which have predominated since the onset of the pandemic. However, it is important to recognize that the pandemic has spurred physicians to think outside the box for medical management by exploring the benefits of various cost-effective supplements, such as Vitamin D and curcumin. In fact, curcumin has been shown to inhibit the angiotensin-converting enzyme2 (ACE-2) pathway within the lungs, and as such, has been theorized to protect against the development of acute respiratory distress (ARDS) or acute lung injury (ALI), two lung processes that are commonly associated with lethal COVID-19 infections.[23] Therefore, we hope our study will shed light on the utility of curcumin and its role in reducing lung inflammation" - See curcumin at Amazon.com and iHerb.
• Compound derived from turmeric essential oil has neuroprotective properties - Science Daily, 7/14/21 - "a component derived from turmeric essential oil, aromatic turmerone (ar-turmerone), and its derivatives act directly on dopaminergic nerves to create a neuroprotective effect on tissue cultures of a Parkinson's disease model. This appears to be due to enhanced cellular antioxidant potency from the activation of Nrf2. The researchers believe that the ar-turmerone derivatives identified in this study can be used as new therapeutic agents for Parkinson's disease" - See turmeric essential oil at Amazon.com.
• Turmeric May Ease Knee Arthritis - NYT, 9/14/20 - "They found that pain, stiffness and physical function all improved significantly more in those who took the curcumin extract than in those who used the placebo. But there was no difference between the groups in the M.R.I. assessment of excess fluid in the synovial cavity, and no difference in knee cartilage structure ... Considering the limited effectiveness of current pharmacological treatments for osteoarthritis, a modest effect may be helpful, and turmeric appears to be without side effects"
• Turmeric Capsules Reduce Knee Osteoarthritis Pain - Medscape, 9/15/20 - "Researchers randomly assigned patients with symptomatic knee osteoarthritis to take two capsules of turmeric capsules (n=36) or placebo (n=34) daily for 12 weeks. At the end of the study period, turmeric improved knee pain on a visual analog scale (VAS) by -9.1 mm (95% CI, -17.8 to -0.4 mm) compared with placebo"
• Turmeric could have antiviral properties - Science Daily, 7/17/20 - "curcumin can prevent Transmissible gastroenteritis virus (TGEV) -- an alpha-group coronavirus that infects pigs -- from infecting cells. At higher doses, the compound was also found to kill virus particles ... curcumin affects TGEV in a number of ways: by directly killing the virus before it is able to infect the cell, by integrating with the viral envelope to 'inactivate' the virus, and by altering the metabolism of cells to prevent viral entry ... Curcumin has been shown to inhibit the replication of some types of virus, including dengue virus, hepatitis B and Zika virus. The compound has also been found to have a number of significant biological effects, including antitumor, anti-inflammatory and antibacterial activities"
• Timed release of turmeric stops cancer cell growth - Science Daily, 6/20/19 - "A Washington State University research team has developed a drug delivery system using curcumin, the main ingredient in the spice turmeric, that successfully inhibits bone cancer cells while promoting growth of healthy bone cells ... Turmeric has been used in cooking and as medicine for centuries in Asian countries, and its active ingredient, curcumin has been shown to have anti-oxidant, anti-inflammatory and bone-building capabilities. It has also been shown to prevent various forms of cancers ... However, when taken orally as medicine, the compound can't be absorbed well in the body. It is metabolized and eliminated too quickly ... The researchers found that their system inhibited the growth of osteosarcoma cells by 96 percent after 11 days as compared to untreated samples. The system also promoted healthy bone cell growth"
• Anti-tumor activity of curcumin on stomach cancer - Science Daily, 4/22/19 - "In addition to curcumin, other compounds found to play a key role in modulating histone activity were cholecalciferol, resveratrol (present mainly in grape seeds and red wine), quercetin (abundant in apples, broccoli and onions), garcinol (isolated from the bark of the kokum tree, Garcinia indica), and sodium butyrate (produced by gut bacteria via fermentation of dietary fiber) ... "These compounds can favor the activation or repression of genes involved in the development of stomach cancer by promoting or inhibiting histone acetylation," Calcagno said ... Curcumin, for example, influences histone modifications primarily by inhibiting HATs and HDACs to suppress cancer cell proliferation and induce apoptosis (programmed cell death). Garcinol, whose chemical structure resembles that of curcumin, inhibits HATs and helps prevent stomach cancer by neutralizing free radicals"
• Curry spice boosts exercise performance in mice with heart failure - Science Daily, 11/29/18 - "curcumin, a main ingredient in curry, may improve exercise intolerance related to heart failure ... the compound may prevent or limit muscle wasting associated with a number of health conditions, including heart failure ... One group of mice with heart failure received daily doses of curcumin for 12 weeks, and another group did not receive treatment ... expression of Nrf2 increased and levels of antioxidant enzymes improved in the animals with heart failure that were given curcumin. In addition, both groups that received curcumin -- even the animals without heart failure -- had improved exercise capacity when compared with the untreated groups"
• Keep an 'Eye' on Curcumin for Ocular Neuroprotection - Medscape, 8/29/18 - "The real advance of this trial was not in proving the neuroprotective activity of curcumin (which had previously been established), but rather in harnessing its power and translating it to clinical relevance. Before the topical formulation was developed, the oral dosage of curcumin necessary to induce an effect previously was estimated to be up to twenty-four 500-mg tablets daily- an amount that precluded its use clinically owing to adverse effects. This nanocarrier delivery system will make a daily topical application of curcumin a viable option if it is shown to be effective in humans"
• Turmeric-derived eye drops could treat glaucoma: study - Science Daily, 7/24/18 - "The research team found the eye drops can reduce the loss of retinal cells in rats, which is known to be an early sign of glaucoma ... Curcumin is an exciting compound that has shown promise at detecting and treating the neurodegeneration implicated in numerous eye and brain conditions from glaucoma to Alzheimer's disease, so being able to administer it easily in eye drops may end up helping millions of people ... After twice-daily use of eye drops in the rats for three weeks, retinal ganglion cell loss was significantly reduced compared to matched controls, and the treatment was found to be well-tolerated with no signs of eye irritation or inflammation"
• Curcumin's Cognitive Benefits Look Convincing - Medscape, 3/1/18 - "The philosophy behind this new nanoparticle version of curcumin (Theracumin®) is that it will lead to better absorption. When this trial was performed, not only did the patients who were randomized to the active form of curcumin have improved memory function at 18 months, but they actually had less amyloid in specific parts of their brain that correlated with Alzheimer's disease." - See Theracumin® curcumin at Amazon.com.
• Curcumin improves memory and mood - Science Daily, 1/23/18 - "The double-blind, placebo-controlled study involved 40 adults between the ages of 50 and 90 years who had mild memory complaints. Participants were randomly assigned to receive either a placebo or 90 milligrams of curcumin twice daily for 18 months ... The people who took curcumin experienced significant improvements in their memory and attention abilities, while the subjects who received placebo did not, Small said. In memory tests, the people taking curcumin improved by 28 percent over the 18 months. Those taking curcumin also had mild improvements in mood, and their brain PET scans showed significantly less amyloid and tau signals in the amygdala and hypothalamus than those who took placebos" - [Nutra USA] [Abstract]
• FDA-approved high blood pressure drug extends life span in roundworms - Science Daily, 12/20/17 - "This is the first report of hydralazine treatment activating the NRF2/SKN-1 signaling pathway. We found the drug extends the life span of worms as well as or better than other potential anti-aging compounds such as curcumin and metformin"
  • Hydralazine - wikipedia.org - "Common side effects include headache and fast heart rate.[1] It is not recommended in people with coronary artery disease or in those with rheumatic heart disease that affects the mitral valve.[1] In those with kidney disease a low dose is recommended ... It was patented in 1949 ... The wholesale cost in the developing world is about 2.78 to 9.11 USD per month ... Hydralazine is not used as a primary drug for treating hypertension because it elicits a reflex sympathetic stimulation of the heart (the baroreceptor reflex).[8] The sympathetic stimulation may increase heart rate and cardiac output, and in people with coronary artery disease may cause angina pectoris or myocardial infarction.[9] Hydralazine may also increase plasma renin concentration, resulting in fluid retention ... Prolonged treatment may cause a syndrome similar to lupus which can become fatal if the symptoms are not noticed and drug treatment stopped"
• The top ingredients for cognition, focus and mood - Nutra USA, 7/14/17 - "omega-3 ... Phosphatidylserine (PS) ... B-vitamins ... Vitamin E ... Lutein ... Citicoline ... Magnesium ... L-theanine ... Curcumin ... Resveratrol ... Blueberry anthocyanins ... Inositol-stabilized arginine silicate ... Spearmint extract ... Ashwaganda ... Bacopa ... Teacrine"
• Plant compounds give '1-2' punch to colon cancer - Science Daily, 7/22/16 - "The combination of two plant compounds that have medicinal properties -- curcumin and silymarin -- holds promise in treating colon cancer ... The combination of phytochemicals inhibited colon cancer cells from multiplying and spreading. In addition, when the colon cancer cells were pre-exposed to curcumin and then treated with silymarin, the cells underwent a high amount of cell death" - See curcumin products at Amazon.com and silymarin at Amazon.com.
• Curcumin's ability to fight Alzheimer's studied - Science Daily, 1/12/15 - "Curcumin has demonstrated ability to enter the brain, bind and destroy the beta-amyloid plaques present in Alzheimer’s with reduced toxicity"
• New research adds spice to curcumin's health-promoting benefits - Science Daily, 11/6/14 - "Curcumin powder was mixed with castor oil and polyethylene glycol in a process called nano-emulsion (think vinaigrette salad dressing), creating fluid teeming with microvesicles that contain curcumin. This process allows the compound to dissolve and be more easily absorbed by the gut to enter the bloodstream and tissues ... concentrations of the emulsified curcumin in blood were more than 10 times higher than of curcumin powder suspended in water"
• Turmeric compound boosts regeneration of brain stem cells - Science Daily, 9/25/14 - "A bioactive compound found in turmeric promotes stem cell proliferation and differentiation in the brain ... The findings suggest aromatic turmerone could be a future drug candidate for treating neurological disorders, such as stroke and Alzheimer's disease"
• Curcumin, special peptides boost cancer-blocking PIAS3 to neutralize cancer-activating STAT3 in mesothelioma - Science Daily, 9/18/14 - "common Asian spice and cancer-hampering molecules show promise in slowing the progression of mesothelioma, a cancer of the lung's lining often linked to asbestos ... application of curcumin, a derivative of the spice turmeric, and cancer-inhibiting peptides increase levels of a protein inhibitor known to combat the progression of this cancer ... asbestos does not always cause this particular cancer that kills 43,000 people worldwide each year. Many mesothelioma patients were never exposed to asbestos" - See curcumin products at Amazon.com.
• Fresh faced: Looking younger for longer - Science Daily, 1/10/14 - "While UVB radiation easily causes sunburn, UVA radiation penetrates deeper, damaging our DNA by generating free radicals which degrades the collagen that gives skin its elastic quality ... the most potent anti-oxidants were those that targeted the batteries of the skin cells, known as the mitochondria. They compared these mitochondrial-targeted anti-oxidants to other non-specific antioxidants such as resveratrol, found in red wine, and curcumin found in curries, that target the entire cell. They found that the most potent mitochondrial targeted anti-oxidant was Tiron which provided 100%, protection of the skin cell against UVA sun damage and the release of damaging enzymes causing stress-induced damage ... Tiron is not a naturally occurring compound and has not yet been tested for toxicity in humans although there have been a few studies on rats ... Antioxidants in our diets from green tea, resveratrol which is found in red wine, turmeric which is used in curries and lycopene found in tomatoes, as well as some components in cosmetic creams, are known to neutralise this damage within the cells. They can slow down the damage and the rate of aging and potentially lower the rate of other sun-induced skin lesions ... Resveratrol, the antioxidant found in red wine, was found to protect against 22% of both the ultraviolet A radiation and stress-induced damage. NAC, a frequently used laboratory-based anti-oxidant, offered 20% protection against oxidative stress and 8% against UVA and curcumin offered 16% protection against oxidative stress and 8% against UVA" - See resveratrol products at Amazon.com, n-acetyl cysteine at Amazon.com and curcumin products at Amazon.com.
• Curcumin may protect premature infants' lungs - Science Daily, 7/2/13 - "Premature infants often need the assistance of ventilators and forced oxygen therapy because they're frequently born with inadequate lung function. These therapies can cause the infants to suffer lasting lung damage and even death ... curcumin provided long-term protection against this damage ... curcumin provided protection against bronchopulmonary dysplasia (BDP), a condition characterized by scarring and inflammation, and against hyperoxia, in which too much oxygen enters the body through the lungs, for up to 21 days after birth. A previous LA BioMed study found curcumin provided protection for up to seven days after birth"
• Food Supplement Linked to Lower PSA in Prostate Cancer - Medscape, 6/10/13 - "A commercially available food supplement that contains pomegranate, broccoli, green tea, and turmeric significantly lowers prostate-specific antigen (PSA) levels ... made headlines around the world and caused the polyphenol-rich supplement, known as Pomi-T (nature Medical Products), to sell out within hours ... to receive the supplement 3 times a day for 6 months or placebo ... At 6-month follow-up, the median increase in PSA was 63.8% lower in the supplement groups than in the placebo group (14.7% vs 78.5; P =.0008). In addition, PSA levels were stable or lower than baseline more often in the supplement group (46% vs 14%"
• Prostate cancer: Curcumin curbs metastases, study shows - Science Daily, 10/12/12 - "The new study was designed to investigate the efficacy of curcumin in the prevention of prostate cancer metastases, and to determine the agent's mechanism of action ... curcumin may be useful in the prevention of breast and prostate cancers -- which are both linked to inflammation -- and in reducing their metastatic potential ... This does not mean that the compound should be seen as a replacement for conventional therapies. However, it could play a positive role in primary prevention -- before a full-blown tumor arises -- or help to avert formation of metastases. In this context the fact that the substance is well tolerated is very important, because one can safely recommend it to individuals who have an increased tumor risk"
• Specific Plants Protect Against Specific, Not All, Cancers - Medscape, 8/29/12 - "Plants do not produce chemicals to help us fight cancer; essentially, plants produce an arsenal of toxic chemicals that kill yeast, bacteria, and insects. Out of this huge chemodiversity, research has shown that some of these chemicals have potent anticancer properties ... Probably the best example of a phytochemical that serves as an antiinflammatory is curcumin. "Turmeric is the most potent source of curcumin, and curcumin is the most potent antiinflammatory phytochemical we know,""
• Curry Compound May Lower Diabetes Risk - WebMD, 7/31/12 - "All of the people in the study had been diagnosed with prediabetes. But according to the findings, none of the participants who took capsules of curcumin for nine months developed type 2 diabetes. By contrast, 16.4% of those who received a placebo did develop type 2 diabetes during the study period"
• Curcumin Holds Promise as Treatment for Brain Tumors - Medscape, 3/29/12 - "Curcumin, a major component of the spice turmeric, has been shown to have chemopreventive and chemotherapeutic properties ... one of the interesting things about curcumin is that it can cross the blood-brain barrier ... Curcumin can induce apoptosis in a variety of tumor cells and has also prevented tumor initiation and growth in experimental models ... curcumin specifically binds to and crosslinks to a protein that is involved in cell-cycle regulation ... is the great thing about curcumin because if it only targets tumor cells, then it has very few — if any — side effects"
• Curcumin and Piperine Prevent Remodeling of Aorta - Medscape, 12/26/11 - "N-nitro-L-arginine-methylester (L-NAME) is a nonspecific inhibitor of all three NO synthase (NOS) isoforms (neuronal - nNOS; inducible - iNOS; endothelial - eNOS) and causes an increase of blood pressure in a dose-dependent manner when administered to the experimental animals ... Administration of piperine or curcumin to animals with L-NAME-induced hypertension lead to a decrease of blood pressure, curcumin causing a more significant drop. Similar hypertension reducing effect of curcumin has been reported recently by Nakmreong et al.[34] Another study[25] registered a significant decrease of blood pressure after intravenous piperine administration. Piperine treatment was effective also in lowering blood pressure in rats with L-NAME-induced experimental hypertension described by Kumar et al.[36] The combination of curcumin and piperine in our experiment did not cause a statistically significant blood pressure decrease (with the exception of the third week) but it is apparent that it copies the course of the piperine graph curve. These differences in the results are probably related to different mechanisms of effect by the spices on blood pressure"
• The Doctor's Remedy: Turmeric for Joint Pain - NYTimes.com, 10/19/11 - "Physician: Dr. Minerva Santos, director of integrative medicine at Northern Westchester Hospital in New York ... Recommended Remedy: Turmeric for joint pain ... What the Doctor Says: ... She recommends a dose of 1,000 milligrams a day. The benefit of buying it in a bottle, she said, is that it’s usually combined with a compound called piperine, which aids absorption"
• Primary component in curry spice kicks off cancer-killing mechanisms in human saliva - Science Daily, 9/12/11 - "Curcumin, the main component in the spice turmeric used in curry, suppresses a cell signaling pathway that drives the growth of head and neck cancer ... The inhibition of the cell signaling pathway also correlated with reduced expression of a number of pro-inflammatory cytokines, or signaling molecules, in the saliva that promote cancer growth ... it not only affected the cancer by inhibiting a critical cell signaling pathway, it also affected the saliva itself by reducing pro-inflammatory cytokines within the saliva ... To be effective in fighting cancer, the curcumin must be used in supplement form. Although turmeric is used in cooking, the amount of curcumin needed to produce a clinical response is much larger. Expecting a positive effect through eating foods spiced with turmeric is not realistic"
• Curry spice could offer treatment hope for tendinitis - Science Daily, 8/9/11 - "Tendons, the tough cords of fibrous connective tissue that join muscles to bones, are essential for movement because they transfer the force of muscle contraction to bones. However, they are prone to injury, particularly in athletes who may overstretch themselves and overuse their joints. Tendinitis (or tendonitis) is a form of tendon inflammation, which causes pain and tenderness near to joints and is particularly common in shoulders, elbows, knees, hips, heels or wrists. Other examples of common tendon disease include tennis and golfer's elbow and Achilles tendinitis ... introducing curcumin in the culture system inhibits NF-kB and prevents it from switching on and promoting further inflammation ... The results follow on from another study by the Nottingham-Munich collaboration, published in the Journal of Biological Chemistry earlier this year, demonstrating that a compound found in red wine could have therapeutic potential for osteoporosis related bone loss in elderly patients, post-menopausal women and patients with rheumatoid arthritis ... The research found that resveratrol, a naturally occurring phytoestrogen found in the skin of red grapes, vines and various other fruits and nuts, inhibits inflammation in bone cells. Its effects extended to inhibiting the formation of osteoclasts, giant congregations of blood-derived cells responsible for bone degeneration, especially in osteoporosis in later life. Resveratrol prevented NF-kB from switching on to trigger inflammation" - See resveratrol products at Amazon.com and curcumin products at Amazon.com.
• Curcumin compound improves effectiveness of head and neck cancer treatment, study finds - Science Daily, 5/19/11 - "A primary reason that head and neck cancer treatments fail is the tumor cells become resistant to chemotherapy drugs. Now, researchers at the University of Michigan Comprehensive Cancer Center have found that a compound derived from the Indian spice curcumin can help cells overcome that resistance ... When researchers added a curcumin-based compound, called FLLL32, to head and neck cancer cell lines, they were able to cut the dose of the chemotherapy drug cisplatin by four while still killing tumor cells equally as well as the higher dose of cisplatin without FLLL32 ... Typically, when cells become resistant to cisplatin, we have to give increasingly higher doses. But this drug is so toxic that patients who survive treatment often experience long-term side effects from the treatment"
• Academic rejects ‘fuzzy math’ claim in spat over curcumin bioavailability - Nutra USA, 4/29/11
• Spice in curry could prevent liver damage - Science Daily, 10/29/10 - "Curcumin, a chemical that gives curry its zing, holds promise in preventing or treating liver damage from an advanced form of a condition known as fatty liver disease ... non-alcoholic steatohepatitis (NASH). Linked to obesity and weight gain, NASH affects 3 to 4 percent of U.S. adults and can lead to a type of liver damage called liver fibrosis and possibly cirrhosis, liver cancer and death ... High levels of leptin activate hepatic stellate cells, which are the cells that cause overproduction of the collagen protein, a major feature of liver fibrosis. The researchers found that among other activities, curcumin eliminated the effects of leptin on activating hepatic stellate cells, which short-circuited the development of liver damage"
• Indian spice may delay liver damage and cirrhosis, study suggests - Science Daily, 3/24/10 - "The findings showed that the curcumin diet significantly reduced bile duct blockage and curbed liver cell (hepatocyte) damage and scarring (fibrosis) by interfering with several chemical signalling pathways involved in the inflammatory process"
• Turmeric Cream Decreases Signs of Aging - Medscape, 3/16/10 - "A new moisturizing cream containing turmeric extract, an ingredient found in curry, significantly improves the appearance of facial spots, fine lines, and wrinkles, according to results from 2 split-face studies (1 with an all-white and 1 with an all-Asian patient population) presented here at the American Academy of Dermatology 68th Annual Meeting"
• Spices may boost breast health: Study - Nutra USA, 12/9/09 - "curcumin, found in turmeric, and piperine, found in black peppers, decreased the number of stem cells while having no effect on normal differentiated cells ... If we can limit the number of stem cells, we can limit the number of cells with potential to form tumours ... normal, non-cancerous stem cells were unaffected by the compounds, which appeared to selectively target the cancer stem cells" - [Abstract]
• Targeting breast stem cells with the cancer preventive compounds curcumin and piperine - Breast Cancer Res Treat. 2009 Nov 7 - "Both curcumin and piperine inhibited mammosphere formation, serial passaging, and percent of ALDH+ cells by 50% at 5 muM and completely at 10 muM concentration in normal and malignant breast cells. There was no effect on cellular differentiation. Wnt signaling was inhibited by both curcumin and piperine by 50% at 5 muM and completely at 10 muM. Curcumin and piperine separately, and in combination, inhibit breast stem cell self-renewal but do not cause toxicity to differentiated cells. These compounds could be potential cancer preventive agents. Mammosphere formation assays may be a quantifiable biomarker to assess cancer preventive agent efficacy and Wnt signaling assessment can be a mechanistic biomarker for use in human clinical trials"
• Curry compound kills cancer cells, study shows - MSNBC, 10/28/09 - "Researchers at the Cork Cancer Research Center in Ireland treated esophageal cancer cells with curcumin — a chemical found in the spice turmeric, which gives curries a distinctive yellow color — and found it started to kill cancer cells within 24 hours ... But these cells showed no evidence of suicide, and the addition of a molecule that inhibits caspases and stops this "switch being flicked' made no difference to the number of cells that died, suggesting curcumin attacked the cancer cells using an alternative cell signaling system"
• Curcumin May Inhibit Nicotine-induced Activation Of Head And Neck Cancers - Science Daily, 10/4/09 - "HNSCC cells were pre-treated with curcumin and then nicotine was introduced. The results of the studies showed that the curcumin was able to block the nicotine from activating cancer ... Although nicotine itself has not been shown to be carcinogenic, it has been shown to encourage the cancer-forming process"
• Vit D-curcumin combo offers brain health potential - Nutra USA, 7/27/09 - "The curcuminoids were found to enhance binding of beta-amyloid to macrophages, and that vitamin D could strongly stimulate the uptake and absorption of beta-amyloid in macrophages in most of the patients ... Since vitamin D and curcumin work differently with the immune system, we may find that a combination of the two or each used alone may be more effective — depending on the individual patient" - [Abstract] - See vitamin D at Amazon.comand curcumin products at Amazon.com.
• Curcumin delays development of medroxyprogesterone acetate-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors - Menopause. 2009 Jul 22 - "Combined hormone therapy (HT) containing estrogen and progestin (medroxyprogesterone acetate [MPA]) leads to increased risk of breast cancer in postmenopausal women, compared with HT regimens containing estrogen alone or placebo ... Treatment with curcumin delayed the first appearance of MPA-accelerated tumors by 7 days, decreased tumor incidence by the end of the experiment, and reduced tumor multiplicity in DMBA-induced MPA-accelerated tumors. Curcumin also prevented many of the gross histological changes seen in the MPA-treated mammary gland. Immunohistochemical analyses of mammary tumors showed that curcumin decreased MPA-induced VEGF induction in hyperplastic lesions, although it did not affect the levels of estrogen and progesterone receptors"
• Curcumin May Prevent Clogged Arteries - WebMD, 7/20/09 - "The current study suggests curcumin may thwart the development of atherosclerosis, or clogged arteries, a key risk factor for heart attacks and strokes ... Researchers in France fed 20 mice a diet supplemented with curcumin or a comparison diet not supplemented with curcumin. After 16 weeks, mice fed on the curcumin-based diet had a 26% reduction in fatty deposits in their arteries compared to mice on the comparison diet ... In addition, curcumin appeared to alter the genetic signaling involved in plaque buildup at the molecular level"
• Vitamin D, Curcumin May Help Clear Amyloid Plaques Found In Alzheimer's Disease - Science Daily, 7/15/09 - "The team discovered that curcuminoids enhanced the surface binding of amyloid beta to macrophages and that vitamin D strongly stimulated the uptake and absorption of amyloid beta in macrophages in a majority of patients ... Since vitamin D and curcumin work differently with the immune system, we may find that a combination of the two or each used alone may be more effective — depending on the individual patient" - See curcumin products at Amazon.com and vitamin D at Amazon.com.
• Asian Spice Could Reduce Breast Cancer Risk In Women Exposed To Hormone Replacement Therapy - Science Daily, 7/13/09 - "curcumin, a popular Indian spice derived from the turmeric root, could reduce the cancer risk for women after exposure to hormone replacement therapy ... curcumin delayed the first appearance, decreased incidence and reduced multiplicity of progestin-accelerated tumors in an animal model. Curcumin also prevented the appearance of gross morphological abnormalities in the mammary glands"
• Compound In Turmeric Spice May Stall Spread Of Fat Tissue - Science Daily, 5/22/09 - "supplementing the animals’ high-fat diet with curcumin reduced body-weight gain and total body fat, even though food-intake was not affected, when compared to the nonsupplemented high-fat-diet group ... The curcumin-treated group also had less blood vessel growth in fat tissue. Blood glucose, triglyceride, fatty acid, cholesterol and liver fat levels also were lower"
• Turmeric Extract Suppresses Fat Tissue Growth In Rodent Models - Science Daily, 5/18/09 - "Curcumin, the major polyphenol found in turmeric, appears to reduce weight gain in mice and suppress the growth of fat tissue in mice and cell models"
• Curcumin may cut body fat and weight gain: Mouse study - Nutra USA, 4/27/09 - "The curcumin suppression of angiogenesis in adipose tissue together with its effect on lipid metabolism in adipocytes may contribute to lower body fat and body weight gain ... Curcumin was also associated with significantly lower cholesterol levels and a reduction in the expression of peroxisome proliferators-activated receptor gamma (PPAR-gamma), a protein that plays a role in metabolic functions" - [Abstract]
• Turmeric: India's 'Holy Powder' Finally Reveals Its Centuries-old Secret - Science Daily, 4/20/09 - "Using a high-tech instrument termed solid-state NMR spectroscopy, the scientists discovered that molecules of curcumin act like a biochemical disciplinarian. They insert themselves into cell membranes and make the membranes more stable and orderly in a way that increases cells' resistance to infection by disease-causing microbes"
• Turmeric Ingredient Makes Membranes Behave For Better Health - Science Daily, 3/6/09 - "curcumin acts as a disciplinarian, inserting itself into cell membranes and making them more orderly, a move that improves cells' resistance to infection and malignancy ... The membrane goes from being crazy and floppy to being more disciplined and ordered, so that information flow through it can be controlled"
• Curry Spice May Thwart Heart Failure - WebMD, 2/26/08
• Indian Spice In Turmeric Reduces Size Of Hemorrhagic Stroke - Science Daily, 9/22/08 - "This active ingredient of the Indian curry spice, turmeric, not only lowers your chances of getting cancer and Alzheimer's disease, but may reduce the size of a hemorrhagic stroke ... significantly decreases the size of a blood clot"
• Curcumin Suppresses IgE-Mediated Allergic Response and Mast Cell Activation - Medscape, 6/3/08 - "Two cytokines, TNF-alpha and IL-4, are among those that are critical to allergic inflammation. In studies using the RBL-2H3 tumor mast cell line, the researchers found that curcumin significantly inhibited the antigen-stimulated expression of mRNA for both cytokines, and the secretion of both cytokines in the mast cells, in a dose-dependent manner"
• Ingredient In Yellow Curry Can Reduce Heart Enlargement And May Prevent Heart Failure - Science Daily, 2/21/08 - "Eating curcumin, a natural ingredient in the spice turmeric, may dramatically reduce the chance of developing heart failure"
• Turmeric (Curcumin) review - ConsumerLab.com, 2/6/08 - "ConsumerLab.com found a popular brand to contain 18.7 mcg of lead in a daily serving — the highest amount it has ever reported. Another brand was contaminated with 8.3 mcg of lead. These amounts are well above those to which people are normally exposed and should be avoided ... two other products provided only 11.5% and 49.5%, respectively, of expected curcumin compounds. A fifth product did not specify the part of the plant used — a FDA labeling requirement" - Note:  I get the paid version and it was NSI® Nutraceutical® Sciences Institute Superior™ Turmeric Curcuma Longa that contained the 18.7 mcg of lead and Solgar® Standardize Full Potency™ Turmeric Root Extract that contained the 8.3 mcg. There wasn't any that failed that I call "brand name".
• Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R - Int J Cancer. 2007 Oct 4 - "inclusion of curcumin to the conventional chemotherapeutic agent(s)/regimen could be an effective therapeutic strategy for colorectal cancer"
• Colon Cancer on curcumin and Vectibix - Johns Hopkins, 8/14/07 - "University of Texas researchers treated some human colorectal cancer cells with neurotensin, with and without curcumin. They confirmed that neurotensin started a chain reaction of chemicals that can increase the growth of cancer and also the migration of cancer cells and that curcumin blocked the process ... Curcumin appears to do this by blocking the biochemical signals sent by neurotensin that contribute to colon cancer cell growth and migration (the spread of cancer to other body sites)"
• Curry Spice May Counter Alzheimer's - WebMD, 7/16/07 - "In preliminary lab tests, the chemical helped rid the blood of a key ingredient in Alzheimer's brain plaque"
• Curcumin's anti-cancer mechanism proposed - Nutra USA, 4/13/07
• A Curry A Day Keeps The Doctor Away? - Science Daily, 1/11/07 - "the chemical compound capsaicin -- which is responsible for the burning sensation when we eat chillies -- can kill cells by directly targeting their energy source ... It could mean that patients could control or prevent the onset of cancer by eating a diet rich in capsaicin"
• Tasty curry might have a fringe benefit - USA Today, 1/7/07 - "turmeric, one component of curry spice, almost completely prevented joint swelling in rats with arthritis. Other studies have suggested that the spice could protect against diseases such as heart disease, cancer and Alzheimer's ... many people with arthritis take over-the-counter supplements that contain curcumin, the active ingredient in turmeric ... The curcumin in curry seems to shut down genes that trigger the development and the spread of breast cancer"
• Turmeric Supplements Show Promise in Treating Arthritis - Medscape, 11/17/06 - "This version was used in subsequent experiments and was shown to prevent acute and chronic arthritis ... In addition, turmeric significantly inhibited joint destruction due to arthritis, and inhibited NF-κB, a protein that controls the gene expression of substances that produce an inflammatory response. Turmeric also altered the expression of hundreds of genes involved in joint swelling and destruction and prevented an increase in osteoclasts (cells that break down bone) in joints"
• Curry spice extract may have anti-arthritis potential - Nutra USA, 10/30/06 - "Cartilage destruction in the tibia of the rats was reduced by 66 per cent, and thigh bone mineral density (BMD) destruction was also reduced by 57 per cent, compared to the control solution"
• Curry spice 'help for arthritis' - BBC News, 10/30/06 - "The extract appears to work by prevent a protein that controls when genes are switched on or off from being activated in the joint"
• Spicy Spin on Easing Arthritis - WebMD, 10/30/06 - "Over the next 28 days, the mice in the turmeric group showed less joint inflammation and less joint damage than those in the comparison group ... The turmeric extract apparently curbed certain genes involved in joint inflammation ... The mice in the turmeric group also showed better bone mineral density than those in the comparison group"
• Chemical Found In Curry May Help Immune System Clear Amyloid Plaques Found In Alzheimer's Disease - Science Daily, 10/3/06 - "curcumin -- a chemical found in curry and turmeric -- may help the immune system clear the brain of amyloid beta, which form the plaques found in Alzheimer's disease"
• Chemical in Curry May Cut Colon Cancer - WebMD, 8/2/06 - "Each of the patients then received 480 milligrams of curcumin and 20 milligrams of quercetin three times a day for six months ... The results showed that treatment with the curry and onion compounds reduced the average number of polyps by 60%, and decreased their size by 50%" - See curcumin supplements at Amazon.com and quercetin at Amazon.com.
• Curry And Cauliflower Could Halt Prostate Cancer - Science Daily, 1/15/06 - "The bottom line is that PEITC and curcumin, alone or in combination, demonstrate significant cancer-preventive qualities in laboratory mice, and the combination of PEITC and curcumin could be effective in treating established prostate cancers"
• Early Study Shows Spice Stunts Deadly Spread To Lungs - Science Daily, 10/16/05 - "Curcumin ... inhibits metastasis to the lungs of mice with breast cancer ... Treatment using Taxol alone only "modestly reduced" the incidence of metastases, while the group using curcumin alone and curcumin plus Taxol "significantly reduced" both the incidence and numbers of visible lung metastases"
• Potent Spice Works To Block Growth Of Melanoma In Lab Test - Science Daily, 7/14/05
• Curry Spice May Fight Skin Cancer - WebMD, 7/11/05 - "curcumin, the yellow pigment found in the spice turmeric, kills and stops the growth of melanoma skin cancer cells in laboratory tests"
• Curry Spice May Curb Breast Cancer's Spread - WebMD, 6/9/05 - "Less than a quarter of the mice in the curcumin-plus-Taxol group had cancer that spread to the lungs. So did half of the curcumin group. In comparison, cancer spread to the lungs in three-fourths of the Taxol group and almost all (95%) mice that got no treatment"
• Does a New Pill Contain the Fountain of Youth? - ABC News, 6/2/05 - "It is a combination of five plant ingredients. Two of them are pretty commonplace — green tea and turmeric, a spice used in Indian cooking"
• Curry Spice May Fight Alzheimer's Disease - WebMD, 1/5/05 - "the curry pigment curcumin slows the formation of, and even destroys, accumulated plaque deposits in mouse brains"
• Food for thought: Can diet protect memory? - MSNBC, 12/6/04 - "research increasingly suggests that diet may be important in preventing Alzheimer's ... older dogs fed a diet rich in antioxidants over several years were able to perform tasks — and learn new tricks — far better than fellow canines fed a normal diet ... scientists believe that curcumin, a spice used in India and known for its anti-inflammatory effects, may prevent memory loss"
• Herb Mix Nixes Prostate Cancer in Lab - WebMD, 12/13/02 - "A number of recent studies point to COX-2 as an important factor in cancer-cell growth. In the Columbia studies, Zyflamend decreased COX-2 activity about as well as a potent COX-2-inhibiting drug ... The herbal mix is called Zyflamend, from New Chapter Inc., and has 10 herbs: holy basil, turmeric, ginger, green tea, rosemary, hu zhang, Chinese goldthread, barberry, oregano, and Scutellaria biacalensis"
• Can Herbs Combat Inflammation? - Dr. Weil, 12/3/02 - "Take 400 to 600 milligrams of turmeric extracts (available in tablets or capsules) three times per day or as directed on the product label. Whole turmeric is more effective than isolated curcumin, its major constituent. Look for products standardized for 95% curcuminoids. Be patient: the full benefit takes two months to develop. Don’t use turmeric if you have gallstones or bile duct dysfunction" - See iHerb turmeric products.
• Curry Spice Takes Burn Out of Radiation - WebMD, 10/10/02 - "The study showed that curcumin, the substance in turmeric that gives it and the dishes it flavors a characteristic yellow color, is a natural anti-inflammatory compound. It works in ways similar to the popular Cox-2 inhibiting drugs, including aspirin and Celebrex"
• A Report on Curcumin's Anti-cancer Effects - Life Extension Magazine, 7/02 - "Imagine a natural substance so smart it can tell the difference between a cancer cell and a normal cell; so powerful it can stop chemicals in their tracks; and so strong it can enable DNA to walk away from lethal doses of radiation virtually unscathed. Curcumin has powers against cancer so beneficial that drug companies are rushing to make drug versions. Curcumin is all this and more"
• An Indian Spice for Alzheimer’s? - Dr. Weil, 6/12/02 - "Curcumin blocked the accumulation of beta-amaloid plaque and also appeared to reduce inflammation related to Alzheimer’s disease in neurologic tissue. The rats fed curcumin also performed better on memory tests than rats on normal diets ... Researchers at the University of Illinois have also found that it helps prevent plaque formation. And preliminary studies at Vanderbilt University suggest that curcumin may block the progression of multiple sclerosis ... only low dose curcumin reduced plaque in the Alzheimer’s disease studies ... Turmeric appears to have significant anti-inflammatory and cancer-protective effects as well"
• I would like to know if curcumin is safe for long-term use - Life Extension Magazine, 3/02
• Are you aware of any studies relating to oral curcumin and serum cholesterol levels? - Life Extension Magazine, 1/02
• question regarding your new cholesterol-lowering supplement, Policosanol - Life Extension Magazine, 11/01 - "In the Journal of Molecular Cell Biochemistry, curcumin has been demonstrated, in vivo, to decrease triglycerides and increase HDL."
• Unlocking the power of curcumin - Life Extension Magazine, 9/01 - "research is discovering that curcumin is a powerful carcinogenic inhibitor, slowing cancerous cell proliferation by inducing apoptosis, a pre-programmed set of processes within a cell that results in its death"
• Curcumin protects against mammary tumors in rats - Life Extension Magazine, 8/01
• Cholesterol Reduction - Life Extension Magazine - "human volunteers taking curcumin showed a 29% increase in beneficial HDL cholesterol in only 7 days. Total cholesterol also fell 11.6% and lipid peroxidation was reduced by 33% ..." & other studies
• Natural COX-2 Inhibitors The Future of Pain Relief - Nutrition Science News, 8/00 - "dose-dependent treatment of the cells with curcumin suppressed both BA- and PMA-mediated induction of COX-2 protein, genetic COX-2 expression (as measured by mRNA), and the synthesis of prostaglandin E2. Most impressive, however, was the discovery that curcumin directly inhibited the enzymatic activity of COX-2"
• Cancer Prevention Diet - Nutrition Science News, 8/99 - "Research suggests that curcumin, the bright yellow flavonoid present in turmeric (Curcuma longa) roots, selectively inhibits thromboxane production while sparing prostacyclin. Thromboxane is a potent inflammatory compound produced by the body in response to injury or irritation. It causes blood vessels to constrict and the blood to clot, while prostacyclin is an inflammatory mediator that can respond to tissue injury without leading to further inflammation. Inhibiting thromboxane prevents excessive inflammatory response and reduces damage to vascular endothelia. Curcumin has also been shown to inhibit tobacco smoke mutagenicity, suggesting it may help protect the vascular endothelia from damage caused by smoking"

Abstracts:

• Curcumin inhibits liquid-liquid phase separation of fused in sarcoma and attenuates the sequestration of pyruvate kinase to restore cellular metabolism - Food Funct 2023 May 9 - "The abnormal accumulation of fused in sarcoma (FUS) is a pathological hallmark in a proportion of patients with frontotemporal dementia and amyotrophic lateral sclerosis. Therefore, the clearance of FUS aggregates is a possible therapeutic strategy for FUS-associated neurodegenerative diseases ... Curcumin attenuated FUS aggregation-mediated sequestration of pyruvate kinase and restored cellular metabolism, consequently increasing ATP levels. These results indicate that curcumin is a potent inhibitor of FUS liquid-liquid phase separation and provide novel insights into the effect of curcumin in ameliorating abnormal metabolism" - See curcumin at Amazon.com.
• Curcumin suppressed the proliferation and apoptosis of HPV-positive cervical cancer cells by directly targeting the E6 protein- Phytother Res 2023 May 8 - "Most human papillomavirus (HPV) types, including HPV16 and HPV18, are closely related to the occurrence of cervical cancer, predominantly through the action of viral oncoproteins E6 and E7. Curcumin, the active ingredient of the turmeric plant, has been gaining attention over the past two decades as an antioxidant, anti-inflammatory, and anticancer agent ... In summary, our research shows that curcumin regulates the apoptosis, migration, and invasion of cervical cancer cells, and the mechanism may be related to its ability to downregulate E6. This study provides a foundation for future research on the prevention and treatment of cervical cancer"
• Curcumin (CUMINUP60®) mitigates exercise fatigue through regulating PI3K/Akt/AMPK/mTOR pathway in mice - Aging (Albany NY) 2023 Mar 28 - "Both the caffeine group and curcumin group showed significant improvement in exercise fatigue compared to the control group, as evidenced by the increase in time to exhaustion, as well as the higher quadriceps coefficient, muscle glycogen (MG) content, and increase in the expression of Akt, AMPK, PI3K, and mTOR proteins. While the curcumin group also significantly improved the exercise fatigue of the mice, demonstrating a lower AMP/ATP ratio and lactic acid (LA) content, and increased glycogen synthase (GS), and myonectin content compared to the caffeine group. Therefore, in the present study, we found that curcumin can exert a similar anti-fatigue effect to caffeine and may act by regulating energy metabolism through modulating the expression of the proteins in the PI3K/Akt/AMPK/mTOR pathway."
• Effects of Highly Bioavailable Curcumin Supplementation on Common Cold Symptoms and Immune and Inflammatory Functions in Healthy Japanese Subjects: A Randomized Controlled Study - J Diet Suppl 2023 Mar 16 - "This study aimed to investigate the effects of 12-week consumption of highly bioavailable curcumin (150 mg/day of Theracurmin Super [TS-P1] or Theracurmin [CR-033P]) on common cold symptoms, immune function, and inflammatory markers ... The cumulative number of days for which common cold symptoms persisted was significantly lower in the TS-P1 and CR-033P groups than that in the placebo group. No adverse effects were observed. Consumption of highly bioavailable curcumin, TS-P1 or CR-033P (150 mg/day), for 12 weeks reduced the number of days for which common cold symptoms persisted in healthy Japanese adults"
• The Effect of Curcumin Supplementation on Weight Loss and Anthropometric Indices: An Umbrella Review and Updated Meta-analyses of Randomized Controlled Trials - Am J Clin Nutr 2023 Mar 8 - "Curcumin supplementation may promote weight loss and ameliorate obesity-related complications through its anti-oxidative and anti-inflammatory properties ... Curcumin supplementation significantly reduces anthropometric indices and bioavailability-enhanced formulas are preferred. Augmenting curcumin supplement with lifestyle modification should be an option for weight reduction"
• Evidence for the use of curcumin in radioprotection and radiosensitization - Phytother Res 2023 Mar 10 - "Curcumin has antineoplastic properties and is considered a chemotherapeutic and chemopreventive agent. Curcumin may be associated with radiation therapy (RT) as a radiosensitizer for cancer cells and a radioprotector for normal cells. In principle, it may result in a reduction of RT dosage for the same therapeutic effect on cancer cells, and further reduced damage to normal cells. Though the overall level of evidence is modest, limited to in vivo and in vitro experiences and practically no clinical trials, as the risks of adverse effects are extremely low, it is reasonable to promote the general supplementation with curcumin during RT targeting the reduction of side effects through anti-inflammatory mechanisms"
• Co-administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets - Phytother Res 2023 Mar 8 - "Natural plant phytochemicals are effective against different types of diseases, including cancer. Curcumin, a powerful herbal polyphenol, exerts inhibitory effects on cancer cell proliferation, angiogenesis, invasion, and metastasis through interaction with different molecular targets. However, the clinical use of curcumin is limited due to poor solubility in water and metabolism in the liver and intestine. The synergistic effects of curcumin with some phytochemicals such as resveratrol, quercetin, epigallocatechin-3-gallate, and piperine can improve its clinical efficacy in cancer treatment. The present review specifically focuses on anticancer mechanisms related to the co-administration of curcumin with other phytochemicals, including resveratrol, quercetin, epigallocatechin-3-gallate, and piperine. According to the molecular evidence, the phytochemical combinations exert synergistic effects on suppressing cell proliferation, reducing cellular invasion, and inducing apoptosis and cell cycle arrest"
• Effects of curcumin/turmeric supplementation on obesity indices and adipokines in adults: A grade-assessed systematic review and dose-response meta-analysis of randomized controlled trials - Phytother Res 2023 Mar 7 - "We found that supplementation with curcumin/turmeric significantly reduced body weight (WMD: -0.82 kg, 95% CI: -1.30, -0.35; p = 0.001), body mass index (WMD: -0.30 kg/m2 , 95% CI: -0.53, -0.06, p = 0.013), waist circumference (WMD: -1.31 cm, 95% CI: -1.94, -0.69, p < 0.001), body fat percentage (WMD: -0.88%, 95% CI: -1.51, -0.25, p = 0.007), leptin (WMD = -4.46 ng/mL; 95% CI: -6.70, -2.21, p < 0.001), and increased adiponectin (WMD = 2.48 μg/mL; 95% CI: 1.34, 3.62, p < 0.001). Overall, our study shows that supplementation with curcumin/turmeric significantly improves anthropometric indices of obesity and adiposity-related adipokines (leptin and adiponectin). However, due to high between-studies heterogeneity, we should interpret the results with caution"
• Curcumin Analog, HO-3867, Induces Both Apoptosis and Ferroptosis via Multiple Mechanisms in NSCLC Cells with Wild-Type p53 - Evid Based Complement Alternat Med 2023 Feb 13 - "Our findings point to the possibility that HO-3867 might be employed as a therapeutic agent for treating NSCLC"
• Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials - Cytokine 2023 Feb 15 - "Turmeric and its prominent bioactive compound, curcumin, have been the subject of many investigations with regard to their impact on inflammatory and oxidative balance in the body ... We observed that turmeric/curcumin supplementation significantly reduces levels of inflammatory markers, including CRP (WMD: -0.58 mg/l, 95 % CI: -0.74, -0.41), TNF-α (WMD: -3.48 pg/ml, 95 % CI: -4.38, -2.58), and IL-6 (WMD: -1.31 pg/ml, 95 % CI: -1.58, -0.67); except for IL-1β (WMD: -0.46 pg/ml, 95 % CI: -1.18, 0.27) for which no significant change was found. Also, turmeric/curcumin supplementation significantly improved anti-oxidant activity through enhancing TAC (WMD = 0.21 mmol/l; 95 % CI: 0.08, 0.33), reducing MDA levels (WMD = -0.33 µmol /l; 95 % CI: -0.53, -0.12), and SOD activity (WMD = 20.51 u/l; 95 % CI: 7.35, 33.67). It seems that turmeric/curcumin supplementation might be used as a viable intervention for improving inflammatory/oxidative status of individuals"
• Efficacy of curcumin plus piperine co-supplementation in moderate-to-high hepatic steatosis: A double-blind, randomized, placebo-controlled clinical trial - Phytother Res 2023 Feb 17 - "Non-alcoholic Fatty Liver Disease (NAFLD) is a global health problem that can progress to steatohepatitis and cirrhosis. The aim of this study was to determine the effect of curcumin + piperine on cardiometabolic risk factors, as well as hepatic steatosis and fibrosis in NAFLD patients with moderate-to-high hepatic steatosis ... Curcumin + piperine decreased waist circumference (p = 0.026), systolic blood pressure (p = 0.001), total cholesterol (p = 0.004), low-density lipoprotein-cholesterol (p = 0.006), FBG (p = 0.002), alanine transaminase (p = 0.007) and aspartate transaminase (p = 0.012) compared with placebo. However, fibroscan measurement did not differ between curcumin + piperine and placebo groups (p > 0.05). Fibroscan measurement as a marker of NAFLD improvement did not differ after 12 weeks of curcumin + piperine; however, curcumin + piperine may be considered as an adjunct therapy to improve anthropometric measures, blood pressure, lipid profile, blood glucose, and liver function in NAFLD patients" - See curcumin at Amazon.com and piperine extract at Amazon.com.
• Safety and Efficacy of Moderately-High Dose Turmacin® (Turmerosaccharide >10% w/w) Supplementation on Joint Discomfort in Healthy Adults - A Pilot Proof-of-Concept Single Arm Study - J Diet Suppl 2023 Feb 14 - "Turmeric is well-known for its analgesic, anti-inflammatory and anti-arthritic properties but 69.4% of the turmeric rhizome contains Turmerosaccharides whose clinical benefit is still unexplored. Turmacin®/NR-INF-02 is an aqueous extract of Turmeric containing Turmerosaccharides (>10%w/w) with negligible curcuminoids ... In summary, Turmacin® supplements given at a dose of 2 g/day was safe and tolerable. Similar to the previous study with low dose Turmacin®, there was a significant increase in pain threshold and decrease in the maximum pain score post intervention"
• Herbal Combination Tames Active Ulcerative Colitis: Study - Medscape, 2/2/23 - "Among 42 patients randomized on a 2:1 basis to receive either an enteric-coated pill containing 3 g of curcumin and qing-dai (CurQD) or placebo for 8 weeks, 43% of those assigned to receive the combination met the co-primary endpoint of a significant reduction in disease activity and objective evidence of response, compared with 8% of those assigned to placebo" - See curcumin at Amazon.com and qing-dai at Amazon.com.
• Antiinflammatory Activities of Curcumin and Spirulina: Focus on Their Role against COVID-19 - J Diet Suppl 2023 Feb 2 - "over the past two years, researchers have focused on analyzing the possible role of nutraceuticals in reducing the risk of SARS-CoV-2 infection or mitigating the symptoms of COVID-19. Among nutraceuticals, turmeric, extracted from the rhizome of the Curcuma Longa plant, and spirulina, commercial name of the cyanobacterium Arthrospira platensis, have assumed considerable importance in recent years ... The demonstrated antiviral properties of spirulina and the fact that these cyanobacteria may modulate or modify some mechanisms also involved in the onset of COVID-19, lead us to think that it may have the same importance as curcumin in fighting this disease and to speculate on the possible combined use of these two substances to obtain a synergistic effect" - See curcumin at Amazon.com and spirulina at Amazon.com.
• Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies - Phytother Res 2023 Jan 31 - "The findings of this comprehensive review show the beneficial effects of curcumin-piperine in improving glycemic indices, lipid profile and antioxidant status in diabetes, improving the inflammatory status caused by obesity and metabolic syndrome, reducing oxidative stress and depression in chronic stress and neurological disorders, also improving chronic respiratory diseases, asthma and COVID-19" - See curcumin at Amazon.com and piperine extract at Amazon.com.
• Profiling Inflammatory Biomarkers following Curcumin Supplementation: An Umbrella Meta-Analysis of Randomized Clinical Trials - Evid Based Complement Alternat Med 2023 Jan 16 - "The umbrella of meta-analysis suggests curcumin as a promising agent in reducing inflammation as an adjunctive therapeutic approach in diseases whose pathogenesis is related to a higher level of inflammatory biomarkers"
• A systematic review and meta-analysis of randomized controlled trials investigating the effect of the curcumin and piperine combination on lipid profile in patients with metabolic syndrome and related disorders - Phytother Res 2023 Jan 17 - "Metabolic syndrome is characterized by multiple metabolic disorders. Several studies indicated that curcumin plus piperine could affect lipids profiles in various diseases. The present meta-analysis aims to assess the effect of curcumin plus piperine on lipid profiles in patients with MetS and associated disorders using a systematic review and meta-analysis of randomized controlled trials ... Our results showed that co-administration of piperine and curcumin supplementation improves the lipid profile in metabolic syndrome. However, further long-term RCTs are required to ascertain their clinical benefit" - See curcumin at Amazon.com and piperine extract at Amazon.com.
• Curcumin suppresses cell proliferation and reduces cholesterol absorption in Caco-2 cells by activating the TRPA1 channel - Aging (Albany NY) 2023 Jan 11 - Lipids Health Dis 2023 Jan 14 -0 "Curcumin (Cur) is a bioactive dietary polyphenol of turmeric with various biological activities against several cancers. Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths. Intestinal cholesterol homeostasis is associated with CRC. Chemotherapy for CRC is related to varied adverse effects. Therefore, natural products with anti-cancer properties represent a potential strategy for primary prevention of CRC ... Cur inhibits cell proliferation and reduces cholesterol absorption in Caco-2 cells through the Ca2+/PPARγ/SP-1/SREBP-2/NPC1L1 signaling by activating the TRPA1 channel, suggesting that Cur can be used as a dietary supplement for the primary prevention of CRC. In Caco-2 cells, Cur first stimulates calcium influx by activating the TRPA1 channel, further upregulates PPARγ and downregulates SP-1/SREBP-2/NPC1L1 signaling pathway, and finally inhibits the absorption of cholesterol. TRPA1, transient receptor potential cation channel subfamily A member 1; NPC1L1, Niemann-Pick C1-like 1; PPARγ, peroxisome proliferator-activated receptor gamma; SP-1, specificity protein-1; SREBP-2, sterol regulatory element-binding protein-2; Cur, curcumin"
• Curcumol inhibits breast cancer growth via NCL/ERα36 and the PI3K/AKT pathway - Food Funct 2022 Dec 20 - "Breast cancer (BC) is the most common malignancy worldwide. ERα36 (ERα66 variant) is expressed in many breast cancer cells, especially highly expressed in tamoxifen (TAM)-resistant cell lines and triple-negative breast cancer, and our previous work revealed that nucleolin (NCL) is a protein target of curcumol ... Curcumol reduced the proliferation of breast cancer cells by targeting NCL/ERα36 and inactivating the PI3K/AKT pathway"
• Curcumin Regulates Gut Microbiota and Exerts a Neuroprotective Effect in the MPTP Model of Parkinson's Disease - Evid Based Complement Alternat Med 2022 Nov 24 - "Curcumin regulates gut microbiota and exerts a neuroprotective effect in the MPTP mice model. This preliminary study demonstrates the therapeutic potential of curcumin for Parkinson's disease, providing clues for microbially targeted therapies for Parkinson's disease"
• Dietary Turmeric Consumption Alleviates Ulcerative Colitis via Restoring Tryptophan Metabolism and Alleviating Gut Microbiota Dysbiosis in Mice - J Agric Food Chem 2022 Nov 22 - "Collectively, these findings manifest the protective actions of dietary TP consumption against ulcerative colitis via restoring the intestinal microbiota disorders, promoting microbial metabolism, and improving intestinal barrier damage" - See turmeric extract at Amazon.com.
• Curcuminoids, a major turmeric component, have a sleep-enhancing effect by targeting the histamine H1 receptor - Food Funct 2022 Nov 21 - "we conclude that curcuminoids reduce sleep latency and enhance the quantity of NREMS by acting as modulators of H1R, indicating their usefulness in treating insomnia"
• Curcumol alleviates liver fibrosis through inducing autophagy and ferroptosis in hepatic stellate cells - FASEB J 2022 Dec - "To explore the effect of curcumol on autophagy and ferroptosis of hepatic stellate cells, and to clarify the molecular mechanism of its anti-hepatic fibrosis. In the present study, we report that curcumol promotes the death of activated HSCs and reduces the deposition of extracellular matrix. Interestingly, curcumol treatment can trigger ferroptosis to eliminate activated HSCs characterized by iron overload, lipid ROS accumulation, glutathione depletion, and lipid peroxidation. Curcumol promotes HSC autophagy, which may be the key mechanism for its induction of ferroptosis. It is worth noting that the upregulation of nuclear receptor coactivator 4 (NCOA4) may play a key molecular mechanism. NCOA4 mediates the release of iron ions and induces the occurrence of ferroptosis. Overall, curcumol promotes autophagy in hepatic stellate cells, mediates the degradation of NCOA4 and FTH1 complexes, releases iron ions, leads to iron overload, and induces ferroptosis, which may be an important mechanism for its anti-hepatic fibrosis effect"
• Therapeutic Effect of Curcumin on 5/6Nx Hypertriglyceridemia: Association with the Improvement of Renal Mitochondrial β-Oxidation and Lipid Metabolism in Kidney and Liver - Antioxidants (Basel) 2022 Nov 6 - "Chronic kidney disease (CKD) prevalence is constantly increasing, and dyslipidemia in this disease is characteristic, favoring cardiovascular events. However, the mechanisms of CKD dyslipidemia are not fully understood. The use of curcumin (CUR) in CKD models such as 5/6 nephrectomy (5/6Nx) has shown multiple beneficial effects, so it has been proposed to correct dyslipidemia without side effects ... Our results showed that CUR reversed the increase in liver and kidney damage and hypertriglyceridemia induced by 5/6Nx. CUR also reversed mitochondrial membrane depolarization and β-oxidation disorders in the kidney and the increased lipid uptake and the high levels of proteins involved in fatty acid synthesis in the liver and kidney. CUR also decreased lipogenesis and increased mitochondrial biogenesis markers in the liver. Therefore, we concluded that the therapeutic effect of curcumin on 5/6Nx hypertriglyceridemia is associated with the restoration of renal mitochondrial ß-oxidation and the reduction in lipid synthesis and uptake in the kidneys and liver"
• Effects of curcumin, a bioactive component of turmeric, on type 2 diabetes mellitus and its complications: an updated review - Food Funct 2022 Nov 11 - "Type 2 diabetes mellitus (T2DM) is a substantial issue in public health. Recently, there has been considerable interest in the effectiveness of using herbal supplements for T2DM. Among the herbal supplements, turmeric (Curcuma longa L.) has been attracting an avalanche of attention owing to its main component, curcumin ... Studies on diabetic humans and animals have revealed that curcumin may have positive effects on oxidative stress and inflammation and may reduce fasting blood glucose levels, increase insulin sensitivity/secretion and regulate the lipid profile. Thus, it may prevent and treat diabetes by affecting various molecular targets"
• Curcumin Represses Colorectal Cancer Cell Proliferation by Triggering Ferroptosis via PI3K/Akt/mTOR Signaling - Nutr Cancer 2022 Nov 8 - "Curcumin is known to suppress the progression of colorectal cancer by inhibiting cancer cell proliferation ... Curcumin triggers ferroptosis and suppresses proliferation of colorectal cancer cells by inhibiting the PI3K/Akt/mTOR signaling pathway. These results indicate its potential as a treatment against colorectal cancer."
• Curcumin alleviates LPS-induced intestinal homeostatic imbalance through reshaping gut microbiota structure and regulating group 3 innate lymphoid cells in chickens - Food Funct 2022 Oct 28 -"Gastrointestinal dysfunction is associated with a disturbance of immune homeostasis, changes in the intestinal microbiome, alteration of the composition of the bile acid pool, and dynamic imbalance of group 3 innate lymphoid cells (ILC3s). Curcumin (CUR), a polyphenolic compound isolated from turmeric, has been known to attenuate intestinal inflammation in potential therapies for gastrointestinal disease ... Dietary supplementation of CUR increased the prevalence of Butyricicoccus and Enterococcus and enhanced the tricarboxylic acid cycle of intestinal epithelial cells. In addition, curcumin supplementation significantly increased sirtuin 1 and sirtuin 5 transcription and protein expression, which contributes to regulating mitochondrial metabolic and oxidative stress responses to alleviate LPS-induced enteritis. Our findings demonstrated that curcumin played a pivotal role in regulating the structure of the intestinal microbiome for health promotion and the treatment of intestinal dysbiosis. The beneficial effects of CUR may be attributed to the modulation of the BA-FXR pathway and inhibition of inflammation that induces IL-22 secretion by ILC3s in the intestinal lamina propria"
• Treatment of Gout with TCM Using Turmeric and Corn Silk: A Concise Review Article and Pharmacology Network Analysis - Evid Based Complement Alternat Med 2022 Oct 14 - "This work aimed to study the compounds, targets, and pathways of turmeric and corn silk for gout and to explore the mechanism of "the same disease with different treatments" based on network pharmacology and molecular docking ... Turmeric and corn silk can treat the same disease, gout, through different pathways and targets. The scientific connotation of "same disease with different treatments" can be preliminarily clarified by analyzing targets and pathways" - See curcumin at Amazon.com and corn silk extract at Amazon.com.
• The Pharmacological Mechanism of Curcumin against Drug Resistance in Non-Small Cell Lung Cancer: Findings of Network Pharmacology and Bioinformatics Analysis - Evid Based Complement Alternat Med 2022 Oct 14 - "Curcumin in combination with immunotherapy, chemotherapy, or targeted drugs has the potential to be effective for drug-resistant NSCLC"
• Protective effects of curcumin on ischemia/reperfusion injury - Phytother Res 2022 Sep 19 - "Ischemia/reperfusion (I/R) injury is a term used to describe phenomena connected to the dysfunction of various tissue damage due to reperfusion after ischemic injury. While I/R may result in systemic inflammatory response syndrome or multiple organ dysfunction syndrome, there is still a long way to improve therapeutic outcomes. A number of cellular metabolic and ultrastructural alterations occur by prolonged ischemia. Ischemia increases the expression of proinflammatory gene products and bioactive substances within the endothelium, such as cytokines, leukocytes, and adhesion molecules, even as suppressing the expression of other "protective" gene products and substances, such as thrombomodulin and constitutive nitric oxide synthase (e.g., prostacyclin, nitric oxide [NO]). Curcumin is the primary phenolic pigment derived from turmeric, the powdered rhizome of Curcuma longa. Numerous studies have shown that curcumin has strong antiinflammatory and antioxidant characteristics. It also prevents lipid peroxidation and scavenges free radicals like superoxide anion, singlet oxygen, NO, and hydroxyl"
• Piperine Enhances the Antimalarial Activity of Curcumin in Plasmodium berghei ANKA-Infected Mice: A Novel Approach for Malaria Prophylaxis - Evid Based Complement Alternat Med 2022 Sep 5 - "The delayed onset of clinical symptoms and prolonged survival rate were also significant (p < 0.05) in the combination of curcumin and piperine treated group. In addition, the low parasitic load in the liver and mild histopathological changes in the liver suggest that the combination of curcumin and piperine had synergistic or additive effects. These findings demonstrate the promising use of these combined compounds as a malarial prophylactic" - See piperine extract at Amazon.com and curcumin at Amazon.com.
• Curcumin as a novel approach in improving lipid profile: An umbrella meta-analysis - Nutr Metab Cardiovasc Dis 2022 Aug 6 - "Curcumin have ameliorating effects on TC, TG, LDL-c, and HDL-c levels. Overall, Curcumin could be recommended as an adjuvant anti-hyperlipidemic agent"
• Curcumin activates Nrf2/HO-1 signaling to relieve diabetic cardiomyopathy injury by reducing ROS in vitro and in vivo - FASEB J 2022 Sep - "The hallmark feature of Diabetes mellitus (DM) is hyperglycemia which can lead to excess production of reactive oxygen species (ROS) in the myocardium, contributing to diabetic cardiomyopathy (DCM) ... In conclusion, these findings conclusively infer that CUR activation of the Nrf2/HO-1 signaling pathway exerts myocardial protection by reducing ROS formation"
• Curcumol Inhibits the Development of Prostate Cancer by miR-125a/STAT3 Axis - Evid Based Complement Alternat Med 2022 Jul 30 - "This study aimed to learn the antineoplastic activity of curcumol (Cur) on prostate cancer (PCa) and elucidate its potential molecular mechanism ... Cur inhibited the development of PCa by miR-125a/STAT3 axis. This may provide a potential agent for treating PCa"
• Curcumin Alleviates D-Galactose-Induced Cardiomyocyte Senescence by Promoting Autophagy via the SIRT1/AMPK/mTOR Pathway - Evid Based Complement Alternat Med 2022 Jul 16 - "Oxidative stress and impaired autophagy are the hallmarks of cardiac aging. However, there are no specific drugs available to prevent cardiac aging. Curcumin is a natural polyphenolic drug with antioxidant, antiaging, and autophagy-promoting effects. Here, we describe the preventive role of Curcumin in cardiac aging through the induction of autophagy and the restoration of autophagy via the SIRT1/AMPK/mTOR pathway. The number of cells positive for senescence-associated β-galactosidase, P53, P16, and intracellular ROS increased significantly in senescent cardiomyocytes, stimulated using D-galactose. Curcumin reversed this effect in a dose-dependent manner. Curcumin-induced autophagy increased the expression of SIRT1and phosphorylated AMPK and decreased phosphorylated mTOR in a dose-dependent manner. SIRT1-siRNA-mediated knockdown inhibited the antioxidation, antiaging, the promotion of autophagy, and the SIRT1/AMPK/mTOR pathway activation effect of curcumin. Therefore, curcumin could be an effective anticardiac aging drug"
• Complexity of Tumor Microenvironment: Therapeutic Role of Curcumin and Its Metabolites - Nutr Cancer 2022 Jul 11 - "The tumor microenvironment (TME) is a complex network of cellular and non-cellular components surrounding the tumor ... Curcumin and its metabolites regulate TME by inhibiting the growth of its cellular components such as cancer-associated adipocytes, cancer-associated fibroblast, tumor endothelial cells, tumor-stimulating immune cells, and inducing anticancer immune cells. They also inhibit the interplay of tumor cells to TME by suppressing non-cellular components such as extracellular matrix, and associated tumor promoting signaling-pathways. In addition, curcumin inhibits the inflammatory environment, suppresses angiogenic factors, and increases antioxidant status in TME. Overall, curcumin has the capability to regulate TME components and their interaction with tumor cells"
• Curcumenol Targeting YWHAG Inhibits the Pentose Phosphate Pathway and Enhances Antitumor Effects of Cisplatin - Evid Based Complement Alternat Med 2022 Jun 26 - "Cervical cancer is a common cancer in women. The drug resistance of chemotherapeutic agents has always been an urgent problem to be solved in clinics. The purpose of this study was to determine the role of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide (YWHAG) in cervical cancer and explore the effect of Curcuma on cervical cancer and its possible mechanism ... Curcumenol can enhance cisplatin to inhibit cancer cell proliferation, migration, and invasion and promote tumor cell apoptosis. The combination of drugs may promote the apoptosis of cervical cancer cells through the YWHAG pathway"
  • Curcumenol - Pub Chem - "Curcumenol is a natural product found in Curcuma aeruginosa, Curcuma longa, and other organisms with data available"
  • Turmeric - Wikipedia - "Turmeric ... is a flowering plant, Curcuma longa"
• Preclinical studies of the antitumor effect of curcumin-loaded polymeric nanocapsules: A systematic review and meta-analysis - Phytother Res 2022 Jul 1 - "Curcumin, a plant-derived compound, has various well-known biological effects (anti-inflammatory, antioxidant, antitumor, among others) as well as some important limitations for formulators, such as poor water solubility and low oral bioavailability. Its nanoencapsulation is reported to overcome these drawbacks and to improve its in vivo efficacy. Here, data from preclinical in vivo studies evaluating the antitumor efficacy of curcumin-loaded polymeric nanocapsules are collected, analyzed, and discussed as a systematic review ... The evidence that curcumin-loaded polymeric nanocapsules inhibits tumor growth (SMD: -3.03; 95% CI: -3.84, -2.21; p < 0.00001) and decreases tumor weight (SMD: -3.96; 95% CI: -6.22, -1.70; p = 0.0006) in rodents is established, regardless of the solid tumor model. To assess the quality of the studies included in the review a bias risk analysis was performed using the SYRCLE's RoB tool. Therefore, encapsulation in polymeric nanocapsules represents an important tool to improve the antitumor effects of curcumin, and this systematic review paves the way for future clinical studies and the translation of curcumin formulations into novel nanomedicines for human cancer treatment" - See nano encapsulation curcumin at Amazon.com.
• Curcumin Increased the Sensitivity of Non-Small-Cell Lung Cancer to Cisplatin through the Endoplasmic Reticulum Stress Pathway - Evid Based Complement Alternat Med 2022 Jun 17 - "Non-small-cell lung cancer (NSCLC) is one of the most lethal cancers. Although cisplatin-based chemotherapies have been regarded as a promising treatment approach, cisplatin resistance still remains one of the major clinical challenges. Curcumin, a naturally occurring polyphenol, has been proved to increase chemotherapeutic efficiency of NSCLC cells ... Curcumin can increase the sensitivity of NSCLC to cisplatin through an ER stress pathway and thus can be served as one of the molecular targets for overcoming the cisplatin resistance" - See curcumin at Amazon.com.
• The Effect of Curcumin on Lipid Profile and Glycemic Status of Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis - Evid Based Complement Alternat Med 2022 Jun 17 - "The estimated pooled mean changes with curcumin were -18.97 mg/dL (95% CI: -36.47 to -1.47; P=0.03) for triglyceride (TG), -8.91 mg/dL (95% CI: -14.18 to -3.63, P=0.001) for total cholesterol (TC), -4.01 mg/dL (95% CI: -10.96 to 2.95, P=0.259) for low density lipoprotein cholesterol (LDL-c), 0.32 mg/dL (95% CI: -0.74 to 1.37, P=0.557) for high density lipoprotein cholesterol (HDL-c), -8.85 mg/dL (95% CI: -14.4 to -3.29, P=0.002) for fasting blood glucose (FBG), -0.54 (95% CI: -0.81 to -0.27, P ≤ 0.001) for glycated hemoglobin (HbA1c) (%) compared with controls ... curcumin supplementation had beneficial effects on glycemic status and some lipid parameters in patients with T2DM"
• Nanocurcumin substantially alleviates noise stress-induced anxiety-like behavior: the roles of tight junctions and NMDA receptors in the hippocampus - Behav Brain Res 2022 Jun 21 - "Environmental noise stress affects non-auditory brain regions such as the hippocampus; an area of the brain implicated in cognition and emotion. Recent experimental data indicate that dysfunction of the blood-brain barrier (BBB) and overexpression of NMDA receptors may cause anxiety. In this experiment, we evaluated the effect of nanocurcumin on anxiety-like behavior and the expression of tight junctions and NMDA receptor subunits in the hippocampus of rats exposed to traffic noise. Forty rats were assigned to control (CON), stress (ST), nanocurcumin (NC), and nanocurcumin+stress (NC+ST) groups ... Our findings showed that noise exposure promotes stress and anxiety and impairs the NMDA receptor structure and BBB integrity. The nanocurcumin treatment displayed partly restored the destructive effects of noise exposure"
• Curcumin Improved Intestinal Epithelial Barrier Integrity by Up-Regulating ZO-1/Occludin/Claudin-1 in Septic Rats - Evid Based Complement Alternat Med 2022 Jun 7 - "To investigate the protective effect and mechanism of curcumin on intestinal barrier function in rats with enterogenic sepsis ... Curcumin can reduce inflammatory response and upregulate the expression of intestinal tight junction proteins ZO-1, occludin, and claudin-1 in rats with enterogenic sepsis, and protect intestinal barrier function"
• 11β-HSD1 Inhibitor Alleviates Non-Alcoholic Fatty Liver Disease by Activating the AMPK/SIRT1 Signaling Pathway - Nutrients 2022 Jun 6 - "We investigated the effect of an 11β-HSD1 inhibitor (H8) on hepatic steatosis and its mechanism of action. Although H8, a curcumin derivative, has been shown to alleviate insulin resistance, its effect on non-alcoholic fatty liver disease (NAFLD) remains unknown ... Our findings demonstrate that H8 alleviates hepatic steatosis, by inhibiting 11β-HSD1, which activates the AMPK/SIRT1 signaling pathway"
• Nano-curcumin supplementation in critically ill patients with sepsis: a randomized clinical trial investigating the inflammatory biomarkers, oxidative stress indices, endothelial function, clinical outcomes and nutritional status - Food Funct 2022 May 27 - "Sepsis is a severe reaction and excessive immune response to infection, which can lead to organ dysfunction, and death. This study aimed to investigate the protective effect of nano-curcumin (NC) on inflammatory biomarkers, endothelial function, oxidative stress indices, biochemical factors, nutritional status, and clinical outcomes in patients with sepsis ... Supplementation with NC may be a promising treatment strategy for critically ill patients with sepsis"
• Impact of curcumin, quercetin, or resveratrol on the pathophysiology of endometriosis: A systematic review -  Phytother Res 2022 May 18 - "Endometriosis, a gynecological disease that affects reproductive age women is difficultly controlled in the long term by currently available treatments, prompting patients to adopt self-controlled interventions including dietary changes ... By acting on mechanisms of inflammation, oxidative stress, cell proliferation, invasion and adhesion, apoptosis, angiogenesis and glucose and lipid metabolism, curcumin, quercetin, and resveratrol showed to have beneficial effects, evidencing their potential application in the endometriosis treatment" - See curcumin at Amazon.com, quercetin at Amazon.com and resveratrol products at Amazon.com.
• Docosahexaenoic acid-acylated curcumin diester alleviates cisplatin-induced acute kidney injury by regulating the effect of gut microbiota on the lipopolysaccharide- and trimethylamine- N-oxide-mediated PI3K/Akt/NF-κB signaling pathway in mice - Food Funct 2022 May 16 - "An increasing number of studies have reported the effects of curcumin (Cur) and docosahexaenoic acid (DHA) on alleviating acute kidney injury (AKI) ... An increasing number of studies have reported the effects of curcumin (Cur) and docosahexaenoic acid (DHA) on alleviating acute kidney injury (AKI). In this work, we have performed a comparative investigation to determine the effect of dietary DHA-acylated Cur esters, ester derivatives of Cur, and recombination of curcumin and DHA on alleviating acute kidney injury in a mouse model induced by a single intraperitoneal injection with cisplatin (20 mg kg-1). The results showed that the DHA-acylated Cur diesters significantly decreased the abnormally increased blood urea nitrogen, creatinine, lipopolysaccharide (LPS) and trimethylamine-N-oxide (TMAO) in serum caused by AKI ... the DHA-acylated Cur diester treatment remarkably changed the relative abundance of microbiota related to LPS and TMAO/trimethylamine (TMA) metabolism. Moreover, dietary DHA-acylated Cur diesters clearly reduced the MDA content and elevated GSH levels in the kidney of AKI mice, as well as changed the fatty acid composition in the kidney. Further mechanism studies showed that DHA-acylated Cur diesters significantly inhibited inflammation, apoptosis and oxidative stress by preventing the LPS and TMAO-mediated PI3K/Akt/NF-κB signaling pathway. The above results indicate that DHA-acylated Cur diesters are a potentially novel candidate or targeted dietary pattern to prevent and treat drug-induced acute kidney injury" - See docosahexaenoic acid at Amazon.com and curcumin at Amazon.com.
• Molecular Mechanism of Curcumin and Its Analogs as Multifunctional Compounds against Pancreatic Cancer - Nutr Cancer 2022 May 18 - "Research evidence suggests that curcumin can influence PC development through multiple molecular mechanisms. The synthesis of novel curcumin analogs and preparation of curcumin nano-formulations are effective strategies to overcome the low bioavailability of curcumin in the treatment of PC. This review aims to summarize the mechanisms of action of curcumin in preclinical and clinical studies on PC and research progress in enhancing its bioavailability"
• The effect of curcumin supplementation on delayed-onset muscle soreness, inflammation, muscle strength, and joint flexibility: A systematic review and dose-response meta-analysis of randomized controlled trials - Phytother Res 2022 May 16 - "To quantify the effects of curcumin supplementation on exercise-induced muscle damage, muscle soreness, inflammatory biomarkers, muscle strength, and joint flexibility via assessment of creatine kinase (CK), visual analogue scale (VAS) score, maximal voluntary contraction (MVC), and range of motion (ROM), respectively ... Meta-analysis showed that curcumin supplementation significantly reduced serum CK activity [WMD = -65.98 IU/L, 95% CI (-99.53 to -32.44)], muscle soreness [WMD = -0.56, 95% CI (-0.84 to -0.27)], and TNF-α concentration [WMD = -0.22 pg/ml, 95% CI (-0.33 to -0.10)]. Also, curcumin supplementation elicited significant improvements in MVC [WMD = 3.10 nm, 95% CI (1.45-4.75)] and ROM [WMD = 6.49°, 95% CI (3.91-9.07)], although no significant changes in IL-6 and IL-8 levels were found. Dose-response analysis indicated that there is a significant non-linear association between the daily dose and the final effect size regarding TNF-α. Curcumin supplementation may improve some aspects of DOMS, including muscle damage, muscle soreness, inflammation, muscle strength, and joint flexibility"
• Combination of Vitamin C and Curcumin Safeguards Against Methotrexate-Induced Acute Liver Injury in Mice by Synergistic Antioxidant Effects - Front Med (Lausanne) 2022 Apr 14 - "Methotrexate (MTX), an antineoplastic and immunosuppressive drug, widely used in the treatment of different types of cancers and the management of chronic inflammatory diseases. However, its use is associated with hepatotoxicity. Vitamin C (VC) and curcumin (CUR) exhibit anti-inflammatory and antioxidant effects ... Pretreatment with VC, CUR or their combination reduces the MTX-induced hepatotoxicity by antioxidant and anti-inflammatory effects. However, the combined effect of VC and CUR provided a synergistic hepatoprotective effect that surpasses pretreatment with CUR alone but seems to be similar to that of VC 200 mg/kg/day. Therefore, VC and CUR combination or a large dose of VC could be effective against MTX-induced hepatotoxicity" - See vitamin C products at Amazon.com and curcumin at Amazon.com.
• Curcumin improves the protective effects of quercetin against atrazine-induced testicular injury in adult Wistar rats - Andrologia 2022 Apr 18 - "This study evaluated the beneficial protective effect of cotreatment of curcumin (CUR) and quercetin (QUE) on atrazine (ATZ)-induced testicular toxicity in rats. ATZ challenge diminished luteinizing hormone, follicular stimulating hormone, testosterone and myeloperoxidase enzyme activity, but these effects were attenuated on co-treatment with CUR and QUE. Also, co-treatment of CUR + QUE was better than separate administration of QUE at diminishing malondialdehyde and glutathione and improving tumour necrosis factor-α concentration, germ cell numbers (spermatogonia, spermatocytes and round spermatids) and epididymal sperm quality ... We conclude that CUR can improve the protective effects of QUE against ATZ-induced testicular injury by enhancing the levels of reproductive hormones, recovering testicular biochemical parameters and improving the histological features of the testes"
• Molecular Targets of Curcumin and Its Therapeutic Potential for Ovarian Cancer - Nutr Cancer 2022 Mar 10 - "Ovarian cancer is the fifth most common gynecological cancer in women globally. Conventional chemotherapy is the first therapeutic approach in the treatment of ovarian cancer, but its success is limited by severe side effects, transient response, and the high prevalence of relapse. Curcumin is a natural product found in the rhizome extract of Curcuma longa and has been extensively used over the last decades for its unique biological and medicinal properties, which include: having antioxidant, analgesic, anti-inflammation, and anti-tumor activities. Curcumin exerts its anticancer properties against ovarian cancer via multiple mechanisms: interfering with cellular interactions necessary for metastasis and recurrence of OC cells, increasing pro-apoptotic proteins as well as inducing or suppressing generation of different molecules such as cytokines, transcription factors, enzymes, protein kinases, and growth factors. Moreover, curcumin down-regulates various signaling pathways such as PI3K/Akt, Wnt/β-catenin, JAK/STAT3, and MEK/ERK1/2 axes, which at least in part have a role in inhibiting further tumor proliferation, growth, and angiogenesis"
• Curcumin alleviates hepatic steatosis by improving mitochondrial function in postnatal overfed rats and fatty L02 cells through the SIRT3 pathway - Food Funct 2022 Feb 21 - "It was concluded that postnatal overfeeding damaged mitochondrial biogenesis and antioxidant response, and increased hepatic lipids and the severity of high-fat-induced NAFLD, while CUR alleviated hepatic steatosis, at least partially, by enhancing mitochondrial function through SIRT3"
• Curcumin regulates the homeostasis of Th17/Treg and improves the composition of gut microbiota in type 2 diabetic mice with colitis - Phytother Res 2022 Mar 2 - "Diabetes mellitus (DM) is one of the most common complications in patients with ulcerative colitis (UC). Curcumin has a wide range of bioactive and pharmacological properties and is commonly used as an adjunct to the treatment of UC and DM ... In this study, curcumin (100 mg/kg/day) significantly improved the symptoms of diabetes complicated by UC, with a lower insulin level, heavier weight, longer and lighter colons, fewer mucosal ulcers and less inflammatory cell infiltration. Moreover, compared to untreated DB mice with colitis, curcumin-treated mice showed weaker Th17 responses and stronger Treg responses. In addition, curcumin regulated the diversity and relative abundance of intestinal microbiota in mice with UC complicated by DM at the phylum, class, order, family and genus levels. Collectively, curcumin effectively alleviated colitis in mice with type 2 diabetes mellitus by restoring the homeostasis of Th17/Treg and improving the composition of the intestinal microbiota"
• Effect of turmeric supplementation on the pharmacokinetics of paclitaxel in breast cancer patients: A study with population pharmacokinetics approach - Phytother Res 2022 Feb 18 - "Turmeric is one of the most used herbal supplements among cancer patients. It reportedly modulates the function of CYP450 enzymes and drug transporters. This study investigates the effect of turmeric on the pharmacokinetics of paclitaxel in breast cancer patients ... turmeric at the recommended dose can be combined safely with paclitaxel" - See turmeric extract at Amazon.com.
• Effects of curcumin supplementation on metabolic parameters, inflammatory factors and obesity values in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial - Phytother Res 2022 Feb 17 - "Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to cartilage damage with mostly accompanied by metabolic disorders. This study aimed to investigate the effects of curcumin supplementation on metabolic parameters (lipid profile and glycemic indices), inflammatory factors, visfatin levels, and obesity values in women with RA ... 48 women with RA. The patients were treated with curcumin (500 mg once a day) or placebo for 8 weeks ... Curcumin supplementation significantly decreased homeostatic model assessment for insulin resistance (HOMA-IR), erythrocyte sedimentation rate, serum levels of high-sensitivity C-reactive protein and triglycerides, weight, body mass index, and waist circumference of patients compared with the placebo at the end of the study (p < .05 for all). HOMA-IR and triglyceride levels significantly increased within the placebo group ... These results support the consumption of curcumin, as a part of an integrated approach to modulate metabolic factors, inflammation, and adiposity in women with RA"
• Curcumin Mitigates TNFα-Induced Caco-2 Cell Monolayer Permeabilization Through modulation of NF-κB, ERK1/2 and JNK Pathways - Mol Nutr Food Res 2022 Feb 19 - "The inhibition of NF-κB, ERK1/2 and JNK activation could be in part involved in the capacity of curcumin to mitigate intestinal inflammation, oxidant production, activation of redox-sensitive pathways, and prevention of monolayer permeabilization. These results support an action of dietary curcumin in sustaining gastrointestinal tract physiology"
• Curcumin alleviates hepatic steatosis by improving mitochondrial function in postnatal overfed rats and fatty L02 cells through the SIRT3 pathway - Food Funct 2022 Feb 3 - "Postnatal overfeeding could increase the risk of non-alcoholic fatty liver disease (NAFLD) in adulthood. This study investigated the effects of curcumin (CUR) on hepatic steatosis in postnatal overfed rats and elucidated potential mechanisms in mitochondrial function ... (normal litter, NL) or three (small litter, SL) ... normal diet (NL) or a high-fat diet (NH) ... At week 13, compared with NL rats, SL and NH rats showed increased body weight, glucose intolerance, dyslipidemia and hepatic lipid accumulation, and these changes were more obvious in SH rats. The opposite trends were observed in SL-CUR and SH-CUR rats. Moreover, CUR could preserve mitochondrial biogenesis and antioxidant response in postnatal overfed rats, and upregulated the mRNA and protein levels of SIRT3. In vitro, L02 cells were exposed to free fatty acids and/or CUR. CUR decreased the levels of cellular lipids and mitochondrial reactive oxygen species, and increased the mitochondrial DNA copy number and superoxide dismutase activity in fatty L02 cells. However, these effects were blocked after SIRT3 silencing. It was concluded that postnatal overfeeding damaged mitochondrial biogenesis and antioxidant response, and increased hepatic lipids and the severity of high-fat-induced NAFLD, while CUR alleviated hepatic steatosis, at least partially, by enhancing mitochondrial function through SIRT3"
• Curcumin Alleviates Dextran Sulfate Sodium-induced Colitis in Mice Through Regulating Gut Microbiota - Mol Nutr Food Res 2022 Feb 2 - "Curcumin is a natural polyphenol compound with multiple pharmacologic activities. The present study aims to explore the potential therapeutic properties of curcumin on intestinal inflammatory diseases, including its anti-inflammatory, anti-oxidant, and anti-apoptotic properties, as well as their associations with altered intestinal microbiome ... curcumin shows therapeutic potential against colitis. It may be served as alternative medicine or adjuvant therapy in the treatment of colitis"
• Curcumin suppress inflammatory response in traumatic brain injury via p38/MAPK signaling pathway - Phytother Res 2022 Jan 25 - "We found that curcumin remarkably ameliorated secondary brain injury after TBI, including effects on the neurological severity score and inflammation. After injection of curcumin, the neurological function score of mice decreased significantly. Curcumin exhibited antiinflammatory pharmacological effects, as reflected by inhibition of inflammatory factors (e.g., interleukin [IL]-1β, IL-6, and tumor necrosis factor [TNF]-α). Additionally, curcumin notably reduced the expression of p-p38 according to western blotting and immunohistochemical analyses. In conclusion, curcumin remarkably alleviated posttraumatic inflammation and thus shows potential for treating inflammation associated with TBI" - See curcumin at Amazon.com.
• An overview of the therapeutic effects of curcumin in reproductive disorders with a focus on the antiinflammatory and immunomodulatory activities - Phytother Res 2022 Jan 18 - "Curcumin, the polyphenolic compound obtained from turmeric, has several pharmacological properties. These properties include antioxidant, antimicrobial, anti-angiogenic, anticarcinogenic, antiinflammatory, and immunomodulatory activities ... Curcumin in the female reproductive system attenuates folliculogenesis, promotes apoptosis of oocytes and blastocyst, and decreases embryo implantation and survival. Curcumin at <100 mg concentration shows protective effects against testicular injury. The concentration of >250 mg of curcumin exhibits immobilizing action on sperms, and at 500 mg concentration completely blocks pregnancy. Curcumin inhibits vaginal infections, attenuates the severity of the premenstrual syndrome, ameliorates inflammatory conditions in polycystic ovary syndrome, improves preeclampsia, and prevents ectopic endometrial lesions. Taken together, curcumin, because of the numerous biological activities, low level of toxicity, and lower adverse effects compared to the synthetic drugs, could be considered as a protective agent for preserving the semen quality parameters, a contraceptive, and chemotherapeutic or chemopreventive agent, as well as an appropriate agent for the treatment of female reproductive disorders"
• Effect of nanocurcumin supplementation on the severity of symptoms and length of hospital stay in patients with COVID-19: A randomized double-blind placebo-controlled trial - Phytother Res 2022 Jan 12 - "This study aimed to determine the effects of nanocurcumin on the severity of symptoms and length of hospital stay (LOS) in COVID-19 patients. Forty-eight COVID-19 patients were randomly assigned into nanocurcumin (n = 24) and placebo (n = 24) groups receiving 160 mg/day nanocurcumin or placebo capsules for 6 days. Mean differences of O2 saturation were significantly higher in patients who received nanocurcumin supplements (p = 0.02). Also, nanocurcumin treatment significantly reduced the scores of domains 3 and 4 and the total score of Wisconsin Upper Respiratory System Survey (WURSS-24), indicating milder symptoms in the treatment group (p = 0.01, 0.03, and 0.01 respectively). Besides, the LOS in curcumin groups was lower than in the placebo group, although the difference was not statistically significant (6.31 ± 5.26 vs. 8.87 ± 8.12 days; p = 0.416). CBC/differentiate, hs-CRP level and the pulmonary involvement in CT scan were not different between the two groups. As nanocurcumin can be effective in increasing O2 saturation and reducing the severity of symptoms in COVID-19 patients, it could probably be used as a complementary agent to accelerate the recovery of patients" - See nano-curcumin at Amazon.com.
• Antiinflammatory potential of nano-curcumin as an alternative therapeutic agent for the treatment of mild-to-moderate hospitalized COVID-19 patients in a placebo-controlled clinical trial - Phytother Res 2022 Jan 17 - "A total of 60 COVID-19 patients were randomly divided into nano-curcumin and control groups, and then they received 240 mg/day nano-curcumin for 7 days ... The evidence demonstrated that nano-curcumin could be implicated as a complementary medication to act as an antiinflammatory agent and inhibit inflammatory complications"
• Dietary curcumin restores insulin homeostasis in diet-induced obese aged mice - Aging (Albany NY) 2022 Jan 11 - "Aging (Albany NY) 2022 Jan 11 - "Although aging is a physiological process to which all organisms are subject, the presence of obesity and type 2 diabetes accelerates biological aging. Recent studies have demonstrated the causal relationships between dietary interventions suppressing obesity and type 2 diabetes and delaying the onset of age-related endocrine changes. Curcumin, a natural antioxidant, has putative therapeutic properties such as improving insulin sensitivity in obese mice ... Aged (18-20 months old) male mice given a high-fat high-sugar diet supplemented with 0.4% (w/w) curcumin (equivalent to 2 g/day for a 60 kg adult) displayed a different metabolic phenotype compared to mice given a high-fat high-sugar diet alone. Furthermore, curcumin supplementation altered hepatic gene expression profiling, especially insulin signaling and senescence pathways. We then mechanistically investigated how curcumin functions to fine-tune insulin sensitivity. We found that curcumin supplementation increased hepatic insulin-degrading enzyme (IDE) expression levels and preserved islet integrity, both outcomes that are beneficial to preserving good health with age. Our findings suggest that the multifaceted therapeutic potential of curcumin can be used as a protective agent for age-induced metabolic diseases"
• Effect of Curcumin on Diabetic Kidney Disease: A Systematic Review and Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Clinical Trials - Evid Based Complement Alternat Med 2021 Dec 2 - "Five RCTs involving 290 participants with DKD were included. Curcumin supplementation significantly improved the serum creatinine (WMD: -0.16 mg/dL, 95% CI: -0.3 to -0.02, P = 0.029, I 2 = 0%, moderate certainty), total cholesterol (WMD: -10.13 mg/dL, 95% CI: -17.84 to -2.14, P = 0.01, I 2 = 0%, moderate certainty), systolic blood pressure (WMD: 3.94 mmHg, 95% CI: 1.86 to 6.01, P < 0.01, I 2 = 33.5%, moderate certainty), and fasting blood glucose (WMD: -8.29 mg/dL, 95% CI: -15.19 to -1.39, P = 0.019, I 2 = 43.7%, moderate certainty) levels; however, it had no significant effects on blood urea nitrogen, proteinuria, triglyceride, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, and diastolic blood pressure levels"
• Efficacy of Cuminum Cyminum supplementation on lipid profile and anthropometric parameters: A systematic review and meta-analysis of randomized controlled clinical trials - Phytother Res 2021 Nov 25 - "We aimed to evaluate the effect of Cuminum Cyminum (CC) supplementation on lipid profile and selected anthropometric parameters ... The data from our eight included studies have indicated that CC supplementation can lower body mass index (BMI) (WMD = -0.88 kg/m2 ; 95%CI: -1.58, -0.18; p = .023) and total cholesterol (TC) (WMD = -3.96 mg/dl; 95%CI: -6.51, -1.04; p=.008). Also, after adjusting for publication bias, CC was shown to be effective in improving waist circumference (WC), high-density lipoprotein (HDL-C), and triglycerides (TG) levels. Although, the current evidence has not shown that CC supplementation can affect low-density lipoprotein (LDL-C), our subgroup analysis has indicated that CC supplementation with supplementation length of more than 8 weeks is associated with beneficial effects on LDL-C"
• Curcumin Protects against Renal Ischemia/Reperfusion Injury by Regulating Oxidative Stress and Inflammatory Response - Evid Based Complement Alternat Med 2021 Nov 13 - "The aim of this study was to explore the pharmacological effects of curcumin on oxidative stress and inflammatory response of renal dysfunction induced by renal ischemia/reperfusion (RIRI) ... superoxide dismutase (SOD) ... Curcumin can relieve the degree of renal injury and improve renal function in ischemia-reperfusion, which may be related to the fact that curcumin can increase SOD content in serum and reduce MDA and FRAP levels in the rat model"
• The Effect of Curcuma longa on Inflammatory Mediators and Immunological, Oxidant, and Antioxidant Biomarkers in Asthmatic Rats - Evid Based Complement Alternat Med 2021 Nov 12 - "The effects of Curcuma longa (C. longa) on total and differential WBC, inflammatory and immunologic mediators, and oxidant and antioxidant biomarkers in bronchoalveolar lavage fluid (BALF) of rats model of asthma were assessed ... Compared to dexamethasone, C. longa exerted more pronounced effects on lung inflammation, oxidative stress, and immune system in asthmatic rats" - See curcumin at Amazon.com.
• Bisdemethoxycurcumin Promotes Apoptosis and Inhibits the Epithelial-Mesenchymal Transition through the Inhibition of the G-Protein-Coupled Receptor 161/Mammalian Target of Rapamycin Signaling Pathway in Triple Negative Breast Cancer Cells - J Agric Food Chem 2021 Nov 23 - "Triple negative breast cancer (TNBC) is one of the leading causes of cancer death in the world and lacks an effective targeted therapy. G-protein-coupled receptor 161 (GPR161) has been demonstrated to perform the functional regulations on TNBC progression and might be a potential new target for TNBC therapy ... bisdemethoxycurcumin (BDMC) ... BDMC significantly inhibited TNBC invasion. The combination treatment of BDMC and rapamycin enhanced the inhibition of TNBC proliferation and metastasis through increasing the blockage of mTOR activation. Furthermore, this study also observed that BDMC activated the caspase 3/9 signaling pathway to induce TNBC apoptosis. Therefore, BDMC could be applicable to anticancer therapy, especially targeting on the GPR161-driven cancer type" - See bisdemethoxycurcumin at Amazon.com.
  • Turmeric, Curcuminoids, And Curcumin Defined - integrativepro - "Although turmeric is thought to possess therapeutic properties, the curcuminoids complex comprises only 2.5-6% of the rhizome of tumeric. Of that, curcumin is approximately 77% of the curcuminoid content.3 To state this differently, it is understood that curcumin is the most abundant curcuminoid. It is also the most studied curcuminoid. Curcuminoids are only a small fraction of the turmeric rhizome and the rhizome is only one part of the plant. Unless explicitly stated that there is a different ratio of curcuminoids, it is assumed that the natural ratio of 77% curcumin, 17% demethoxycurcumin and 3% bisdemethoxycurcumin with variances is maintained in a commercial product"
• Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial - Nutr J 2021 Nov 13 - "We performed a randomized, double-blind, placebo-controlled study in healthy subjects aged 50 to 69 years with overweight. Participants took two capsules containing CLE (CLE group, n = 45) or two placebo capsules (placebo group, n = 45) daily for 12 weeks, and serum inflammatory markers were measured ... After the intervention, the CLE group had a significantly lower body weight (p < 0.05) and body mass index (p < 0.05) than the placebo group and significantly lower serum levels of C-reactive protein (p < 0.05) and complement component 3 (p < 0.05). In addition, the CLE group showed significant improvement of the MOS SF-36 mental health score (p < 0.05) and POMS anger-hostility score"
• Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects - Phytother Res 2021 Oct 25 - "Curcumin is a phytochemical isolated from Curcuma longa with potent tumor-suppressor activity, which has shown significant efficacy in pre-clinical and clinical studies. Curcumin stimulates cell death, triggers cycle arrest, and suppresses oncogenic pathways, thereby suppressing cancer progression. Cisplatin (CP) stimulates DNA damage and apoptosis in cancer chemotherapy. However, CP has adverse effects on several organs of the body, and drug resistance is frequently observed ... Curcumin administration reduces ROS levels to prevent apoptosis in normal cells. Furthermore, curcumin can inhibit inflammation via down-regulation of NF-κB to maintain the normal function of organs. Curcumin and its nanoformulations can reduce the hepatoxicity, neurotoxicity, renal toxicity, ototoxicity, and cardiotoxicity caused by CP. Notably, curcumin potentiates CP cytotoxicity via mediating cell death and cycle arrest. Besides, curcumin suppresses the STAT3 and NF-ĸB as tumor-promoting pathways, to enhance CP sensitivity and prevent drug resistance. The targeted delivery of curcumin and CP to tumor cells can be mediated nanostructures. In addition, curcumin derivatives are also able to reduce CP-mediated side effects, and increase CP cytotoxicity against various cancer types" - See curcumin at Amazon.com.
• Age-related alterations to working memory and to pyramidal neurons in the prefrontal cortex of rhesus monkeys begin in early middle-age and are partially ameliorated by dietary curcumin - Neurobiol Aging 2021 Sep 16 - "Working memory (WM) impairment ... Middle-aged subjects given curcumin exhibited better WM performance and less neuronal excitability compared to control subjects. These findings suggest that the appropriate time frame for intervention for age-related cognitive changes is early middle age, and points to the efficacy of curcumin in delaying WM decline. Because there was no relationship between excitability and behavior, the effects of curcumin on these measures appear to be independent"
• Effects of Curcumin Supplementation on Inflammatory Markers, Muscle Damage, and Sports Performance during Acute Physical Exercise in Sedentary Individuals - Oxid Med Cell Longev 2021 Oct 7 - "Exhaustive and acute unusual physical exercise leads to muscle damage. Curcumin has been widely studied due to the variety of its biological activities, attributed to its antioxidant and anti-inflammatory properties. Furthermore, it has shown positive effects on physical exercise practitioners ... Most studies have shown positive effects of curcumin supplementation in sedentary individuals undergoing acute physical exercise. Overall, participants supplemented with curcumin showed less muscle damage, reduced inflammation, and better muscle performance" - [Nutra USA]
• Radiosensitizing Effect of Curcumin on Human Bladder Cancer Cell Lines: Impact on DNA Repair Mechanisms - Nutr Cancer 2021 Oct 13 - "Chemo-radiotherapy is one of the promising approaches to treat bladder cancer, but its effectiveness is limited to sensitive patients. Polyphenol curcumin has shown anticancer and radiosensitizing potentials, but the mechanism is not fully understood ... curcumin treatment increased the radiosensitivity by modifying the DNA double-strand breaks repair kinetics of the most radioresistant cells UM-UC6 without affecting the radiosensitive UM-UC5. Moreover, UM-UC6 cell survival and proliferation was significantly decreased after the combination of curcumin with radiation. Bladder cell migration was also inhibited considerably. Curcumin was also shown to reduce the number and the volume of bladder cancer spheres of both cell lines. This study revealed that curcumin was able to radiosensitize resistant bladder cell line without affecting the sensitive one with minimal side effects through enhancing DNA damage signaling and repair pathway"
• Combined Supplementation with Vitamin B-6 and Curcumin is Superior to Either Agent Alone in Suppressing Obesity-Promoted Colorectal Tumorigenesis in Mice - J Nutr 2021 Sep 29 - "In this mouse model, C + B is superior to either agent alone in preventing obesity-promoted colorectal carcinogenesis. Augmented suppression of procancerous signaling pathways may be the means by which this augmentation occurs" - See Best Naturals Vitamin B-6 25 mg 250 Tablets at Amazon.com and curcumin at Amazon.com and iHerb.
• Curcumin in a tris-based semen extender improves cryosurvival of Hariana bull spermatozoa - Andrologia 2021 Sep 27 - "In conclusion, curcumin in a semen extender manifests cryoprotective effects and may be incorporated at 10 µM concentration in a Hariana bull semen extender for better post-thaw sperm quality"
• Effect of curcumin on C-reactive protein as a biomarker of systemic inflammation: An updated meta-analysis of randomized controlled trials - Phytother Res 2021 Sep 29 - "There was a significant effect of curcumin at dose ≤1,000 mg/day on the CRP concentration. CRP concentration significantly decreased after >10-week intervention compared with placebo.hs-CRP concentration in the intervention group was significantly lower than that of placebo group. A significant effect of curcumin consumption was detected on the serum level of hs-CRP in studies with prescribing ≤1,000 mg/day, and those with ≤10-week duration of intervention. Curcumin consumption resulted in a reduction of hs-CRP in a non-linear fashion with stronger effects with less than 2000 mg curcumin per day. Curcumin seems to be beneficial in decreasing the hs-CRP and CRP levels in proinflammatory settings"
• Curcumin Alleviated Dextran Sulfate Sodium-Induced Colitis by Regulating M1/M2 Macrophage Polarization and TLRs Signaling Pathway - Evid Based Complement Alternat Med 2021 Sep 16 - "Curcumin has shown good efficacy in mice with experimental colitis and in patients with ulcerative colitis, but the mechanism of action through the regulation of M1/M2 macrophage polarization has not been elaborated ... Our study suggested that curcumin exerted therapeutic effects in colitis mice by regulating the balance of M1/M2 macrophage polarization and TLRs signaling pathway"
• Turmeric root extract supplementation improves pre-frontal cortex oxygenation and blood volume in older males and females: a randomised cross-over, placebo-controlled study - Int J Food Sci Nutr 2021 Sep 22 - "Ageing is associated with endothelial dysfunction and reduced cerebral blood flow and oxygenation. The present study aimed to investigate whether turmeric supplementation could improve cerebral oxygenation and blood volume during brain activation via dynamic handgrip exercise in older males and females ... Participants ingested turmeric root extract or placebo ... The current findings indicate the potential for curcumin as an intervention for improving cerebral oxygenation and blood volume changes in older males and females"
• The clinical use of curcumin on neurological disorders: An updated systematic review of clinical trials - Phytother Res 2021 Sep 15 - "Neuroprotective effects of curcumin have been shown in previous studies ... Curcumin supplementation may have favorable effects on inflammatory status and clinical outcomes of patients with neurological disease, although the results were not consistent"
• The effects of curcumin as dietary supplement for patients with polycystic ovary syndrome: An updated systematic review and meta-analysis of randomized clinical trials - Phytother Res 2021 Sep 13 - "Those findings suggest that CUR confers clinical benefits in patients with PCOS. However, due to the limited number of the included studies, further high-quality studies are needed to establish the clinical efficacy of the CUR"
• Curcumin Reduces Adipose Tissue Inflammation and Alters Gut Microbiota in Diet-Induced Obese Male Mice - Mol Nutr Food Res 2021 Sep 12 - "Curcumin exerts protective metabolic effects in dietary obesity, in part through downregulation of adipose tissue inflammation, which may be mediated by alterations in composition of gut microbiota, and metabolism of curcumin into curcumin-o- glucuronide"
• Current clinical developments in curcumin-based therapeutics for cancer and chronic diseases - "Phytother Res 2021 Sep 8 - "Curcumin, a natural compound extracted from the rhizomes of Curcuma longa, has been under intense scrutiny for its wide medicinal and biological properties. Curcumin is known to manifest antibacterial, antiinflammatory, antioxidant, antifungal, antineoplastic, antifungal, and proapoptotic effects. A plethora of literature has already established the immense promise of curcuminoids in the treatment and clinical management of various chronic diseases like cancer, cardiovascular, metabolic, neurological, inflammatory, and infectious diseases. To date, more than 230 clinical trials have opened investigations to understand the pharmacological aspects of curcumin in human systems"
• Synergistic Protective Effect of Curcumin and Resveratrol against Oxidative Stress in Endothelial EAhy926 Cells - Evid Based Complement Alternat Med 2021 Sep 3 - "Curcumin (C) and resveratrol (R) are two well-known nutraceuticals with strong antioxidant activity that can protect cells from oxidative stress ... C and R as individual compounds as well as CR combinations at different ratios were screened for their protective effects against H2O2 (2.5 mM) induced cell death assessed by cell viability assays ... CR combinations produced a synergistic protection against that of H2O2-induced changes in cell viability, caspase-3 activity, and ROS production. The strongest effect was observed for CR with the ratio of 8 : 2. Further experiments showed that CR 8 : 2 exhibited significantly greater effects in increasing Nrf2 translocation and expressions of Nrf2 and HO-1 proteins, as well as SOD activity and total cellular NAD production, than that of C or R alone. The findings demonstrate that combination of C and R produced a strong synergy in activity against H2O2-induced oxidative stress in EAhy926 cells" - See curcumin at Amazon.com and iHerb and resveratrol products at Amazon.com and resveratrol at iHerb.
• Efficacy and Safety of Curcumin Supplement on Improvement of Insulin Resistance in People with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials - Evid Based Complement Alternat Med 2021 Aug 24 - "Based on the current evidence, curcumin may assist in improving the insulin resistance, glycemic control, and decreased TG and TC in patients with T2DM"
• Comparative pharmacokinetics of Theracurmin, a highly bioavailable curcumin, in healthy adult subjects - Int J Clin Pharmacol Ther 2021 Aug 23 - "In conclusion, this study showed similar systemic exposure between the two Theracurmin products. The absorption of curcumin after the administration of Theracurmin was significantly enhanced compared with curcumin powder" - See Theracurmin at Amazon.com.
• Anti-inflammatory effects of oral supplementation with curcumin: a systematic review and meta-analysis of randomized controlled trials - Nutr Rev 2021 Aug 9 - "Chronic inflammation is a major contributor to the development of noncommunicable diseases. Curcumin, a bioactive polyphenol from turmeric, is a well-known anti-inflammatory agent in preclinical research ... These findings provide evidence for the anti-inflammatory effects of curcumin and support further investigation to confirm dose, duration, and formulation to optimize anti-inflammatory effects in humans with chronic inflammation"
• Regulation on Citrate Influx and Metabolism through Inhibiting SLC13A5 and ACLY: A Novel Mechanism Mediating the Therapeutic Effects of Curcumin on NAFLD - J Agric Food Chem 2021 Aug 11 - "Upregulated de novo lipogenesis (DNL) plays a pivotal role in the progress of the nonalcoholic fatty liver disease (NAFLD). Cytoplasmic citrate flux, mediated by plasma membrane citrate transporter (SLC13A5), mitochondrial citrate carrier (SLC25A1), and ATP-dependent citrate lyase (ACLY), determines the central carbon source for acetyl-CoA required in DNL. Curcumin, a widely accepted dietary polyphenol, can attenuate lipid accumulation in NAFLD ... These findings confirm that curcumin improves the lipid accumulation in the liver by blocking citrate disposition and hence may be used to prevent NAFLD"
• Curcumin-cisplatin chemotherapy: A novel strategy in promoting chemotherapy efficacy and reducing side effects - Phytother Res 2021 Aug 4 - "The efficacy of chemotherapy in cancer therapy is limited due to resistance, treatment selectivity, and severe adverse effects. Immunotherapy, chemotherapy, targeted therapy, radiation, and surgery are the most common therapeutic strategies for treatment, with chemotherapy being the most successful. Nonetheless, these treatments exhibit poor effectiveness due to toxicity and resistance. Therefore, combination therapies of natural products may be used as an effective and novel strategy to overcome such barriers. Cisplatin is a platinum-based chemotherapy agent, and when administered alone, it can lead to severe adverse effects and resistance mechanism resulting in therapeutic failure. Curcumin is a polyphenolic compound extracted from turmeric (Curcuma longa) exhibiting anticancer potential with minimal adverse effects. The combination therapy of curcumin and cisplatin is a novel strategy to mitigate/attenuate cisplatin-related adverse effects and improve the barrier of resistance reducing unwanted effects. However, there are uncertainties on the efficacy of curcumin, and more in depth and high-quality studies are needed"
• A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Assessing Efficacy and Safety of a Novel Low-Dose Turmeric Extract Formulation in Healthy Adults with Chronic Knee Pain - Clin Pharmacol 2021 May 21 - "subjects received either 250 mg WDTE60N capsule (150 mg curcuminoids; n = 53) or appearance-matched placebo capsule (n = 53) once daily for 90 days ... A total of 96 subjects completed the study. WDTE60N reduced VAS score from baseline (5.4 ± 0.9) to day 90 (3.8 ± 0.8) with greater mean reduction than placebo (-1.5 ± 0.7 vs -0.6 ± 0.8, p < 0.0001; 2.5 times). It also significantly improved the time taken for 80-m fast-paced walk test and 9-step stair-climb test; and improved all biomarkers compared to placebo" - [Nutra USA]
• Effects of heavy metal, vitamin, and curry consumption on metabolic syndrome during menopause: a Korean community-based cross-sectional study - Menopause 2021 Jul 19 - "High curry consumption reduced the risk of MetS significantly more than low curry consumption (OR 0.60; 95% CI, 0.39-0.91, P = 0.017) in premenopausal women. Furthermore, an increase in daily vitamin B2 intake by 1 mg reduced the risk of MetS by 45% (OR 0.55; 95% CI, 0.32-0.94, P = 0.028) in postmenopausal women" - See curcumin at Amazon.com and iHerb and vitamin B2 at Amazon.
• A review of therapeutic potentials of turmeric (Curcuma longa) and its active constituent, curcumin, on inflammatory disorders, pain, and their related patents - Phytother Res 2021 Jul 26 - "Turmeric (Curcuma longa) and its constituent, curcumin, have been used for their therapeutic properties for a long time. Most of the medicinal impacts of turmeric and curcumin might be attributed to their anti-inflammatory, antinociceptive, and antioxidant effects ... Several documents and patents disclosed the significance of turmeric and curcumin to apply in several therapeutic, medicinal, and pharmaceutical fields. These phytocompounds could be applied as a supplementary therapy in phytotherapy, inflammatory disorders such as arthritis, inflammatory bowel diseases, osteoarthritis, psoriasis, dermatitis, and different types of pain including neuropathic pain. However, because of inadequate clinical trials, further high-quality studies are needed to firmly establish the clinical efficacy of the plant"
• Effectiveness of Curcuma longa extract versus placebo for the treatment of knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials - Phytother Res 2021 Jul 2 - "The pooled analysis showed that Curcuma longa extract was associated with significantly better pain relief and functional improvement compared with placebo for knee OA ... Current evidence indicates that, compared with placebo, Curcuma longa extract has more benefit in pain relief and functional improvement for symptomatic knee OA" - See curcumin at Amazon.com and iHerb.
• Catechin Metabolites along with Curcumin Inhibit Proliferation and Induce Apoptosis in Cervical Cancer Cells by Regulating VEGF Expression In-Vitro - Nutr Cancer 2021 Jun 12 - "Cervical cancer is the fourth most common cancer and the second cause of cancer-related death among women. Over the past two decades, green tea catechins and curcumin have received much attention for their role in preventing carcinogenesis ... In conclusion, catechin metabolites produced by intestinal microbiota besides the curcumin could serve as a promising therapeutic approach for women with cervical cancer"
• Short Term, Oral Supplementation with Optimized Curcumin Does Not Impair Performance Improvements Associated with High Intensity Interval Training - J Diet Suppl 2021 Jun 11 - "Curcumin may improve athletic performance through a reduction in inflammation following exercise and improve mental states of well-being ... Sixteen males and twenty females participated in a double-blinded, randomized, placebo-controlled trial to explore the effects of Longvida(R) optimized curcumin (1.0 g/day) and or a placebo (PLA) taken daily during a 14 day HIIT protocol. Participants were randomized into two groups, then evaluated in three groups, curcumin-fast (CURF), curcumin-slow (CURS) and placebo. Curcumin-fast and curcumin-slow were separated by their 16.1 km cycling time trial performance (TT) with CURF and CURS determined by a TT <30 min and >30 min at the pre intervention time point, respectively ... Following the internvetion, CONP and CURS experienced with 8.15% and 5.04% improvements in TT performance times, while CURF experienced a 0.57% improvement in TT performance time. No changes were observed with respect to other measures. When curcumin is taken daily in conjunction with 14 days of HIIT on a cycle ergometer, cycling performance in either well trained or more recreationally trained athletes is not impaired. Although the improvements in TT performance were not stasticially significant, they are noteworthy"
• Effects of curcuminoids on inflammatory and oxidative stress biomarkers and clinical outcomes in critically ill patients: A randomized double-blind placebo-controlled trial - Phytother Res 2021 Jun 2 - "Experimental studies have suggested the beneficial effects of curcuminoids as natural polyphenols against traumatic brain injury (TBI). The aim of this study was to investigate the effects of supplementation with curcuminoids on inflammatory and oxidative stress biomarkers, clinical outcomes and nutritional status in critically ill patients with TBI. A total of 62 ICU-admitted adult patients with TBI were randomly allocated to receive either a daily dose of 500 mg curcuminoids or matched placebo via enteral nutrition for 7 consecutive days based on stratified block randomization by age and sex ... Compared with baseline, serum levels of IL-6, TNF-α, MCP-1 and CRP were significantly reduced in patients receiving curcuminoids (p < .05) without any significant changes in placebo group; however, changes in the activities of GPx and SOD in serum were not significant between two groups. Moreover, APACHEII and NUTRIC score were significantly improved following curcuminoids consumption in comparison with placebo (p < .05). The findings of this study suggest that short-term supplementation with curcuminoids may have beneficial effects on inflammation, clinical outcomes and nutritional status of critically ill patients with TBI"
• A comprehensive review of the therapeutic potential of curcumin nanoformulations - Phytother Res 2021 Jun 15 - "Today, due to the prevalence of various diseases such as the novel coronavirus (SARS-CoV-2), diabetes, central nervous system diseases, cancer, cardiovascular disorders, and so on, extensive studies have been conducted on therapeutic properties of natural and synthetic agents. A literature review on herbal medicine and commercial products in the global market showed that curcumin (Cur) has many therapeutic benefits compared to other natural ingredients ... Recently, nanoformulations are emerging as approaches to develop and improve the therapeutic efficacy of various drugs. Many studies have shown that Cur nanoformulations have tremendous therapeutic potential against various diseases such as SARS-CoV-2, cancer, inflammatory, osteoporosis, and so on. These nanoformulations can inhibit many diseases through several cellular and molecular mechanisms"
• Turmeric and vitamin C mitigate testicular atrophy induced by lead diacetate via regulation of GRP-78/17β-HSD pathways in rat's model - Andrologia 2021 May 24 - "TMRC or VIT-C specially in combination group prevents Lead diAC testicular damage via reduction of oxidative injury as well as inflammation, downregulation of GRP-78/BAX and upregulation of 17β-HSD and STAR expression as well as improvement in the histological architecture of the testis" - See turmeric extract at Amazon.com and American Health Ester-c With Citrus Bioflavonoids 500 Mg, 240 Count.
• Curcumin's Effect on Inflammatory Response following Percutaneous Coronary Intervention in Adult Patients with Stable Coronary Heart Disease - Int J Angiol 2021 Jun - "Cardiovascular diseases play major roles in the health problems worldwide especially in Indonesia. Percutaneous coronary intervention (PCI) is a minimally invasive procedure with relatively low complications. However, high inflammatory response post-PCI has showed adverse events even after administration of standard medication. Previous studies showed that curcumin was able to reduce inflammatory response in adult patients with stable coronary heart disease (CHD) ... Either curcumin (45 mg/day) or placebo was given 7 days prior to PCI until 2 days after PCI ... Curcumin significantly reduce the serum hsCRP ( p = 0.006) and sCD40L ( p = 0.002) 7 days before PCI to 48 hours post-PCI. The decrement of hsCRP (-14.2% vs. -7.4%) and sCD40L (-24.3% vs. -13.2%) from 24 to 48 hours post-PCI was higher in the curcumin group than placebo group. The administration of curcumin 45 mg dose daily for 7 days prior PCI until 48 hours post-PCI is useful in reducing inflammatory response post-PCI with stable CHD"
• Pleiotropic nature of curcumin in targeting multiple apoptotic-mediated factors and related strategies to treat gastric cancer: A review - Phytother Res 2021 May 24 - "Gastric cancer (GC) is one of the major reasons for cancer-associated death and exhibits the second-highest mortality rate worldwide. Several advanced approaches have been designed to treat GC; however, these strategies possess many innate complications. In view of this, the upcoming research relying on natural products could result in designing potential anticancer agents with fewer side effects. Curcumin, isolated from the rhizomes of Curcuma longa L. has several medicinal properties like antiinflammatory, antioxidant, antiapoptotic, antitumor, and antimetastatic. Such pleiotropic nature of curcumin impedes the invasion and proliferation of GC by targeting several oncogenic factors like p23, human epidermal factor receptor2 including Helicobacter pylori. The side effect of chemotherapy, that is, chemotherapeutic resistance and radiotherapy could be reduced combination therapy of curcumin. Moreover, the photodynamic therapy of curcumin destroys the cancer cells without affecting normal cells. However, further more potential studies are required to establish the potent efficacy of curcumin in the treatment of GC"
• Curcumin Attenuates Sarcopenia in Chronic Forced Exercise Executed Aged Mice by Regulating Muscle Degradation and Protein Synthesis with Antioxidant and Anti-inflammatory Effects - J Agric Food Chem 2021 May 5 - "The aim of the current study is to investigate the effects of spray dry powders of Curcuma longa containing 40% curcumin (CM-SD), as a new aqueous curcumin formula, on sarcopenia in chronic forced exercise executed 10 month old ICR mice. CM-SD (80 and 40 mg/kg) increased calf thicknesses and strengths, total body and calf protein amounts, and muscle weights in both gastrocnemius and soleus muscles. mRNA expressions regarding muscle growth and protein synthesis were induced, while those of muscle degradation significantly declined in CM-SD treatment. CM-SD decreased serum biochemical markers, lipid peroxidation, and reactive oxygen species and increased endogenous antioxidants and enzyme activities. It also reduced immunoreactive myofibers for apoptosis and oxidative stress markers but increased ATPase in myofibers. These results suggest that CM-SD can be an adjunct therapy to exercise-based remedy that prevents muscle disorders including sarcopenia by anti-apoptosis, anti-inflammation, and antioxidation-mediated modulation of gene expressions related to muscle degradation and protein synthesis" - See curcumin at Amazon.com.
• A Novel Potent Sleep-promoting Effect of Turmeric: Turmeric Increases Non-rapid Eye Movement Sleep in Mice Via H 1 -receptor Blockade - Mol Nutr Food Res 2021 May 18 - "turmeric extract (TE) ... TE has a sleep-promoting effect owing to reduction in sleep latency and enhancement of NREMS via H1 R blockade; therefore, it could be useful in insomnia" - See turmeric extract at Amazon.com.
• The effect of curcumin and zinc co-supplementation on glycemic parameters in overweight or obese prediabetic subjects: A phase 2 randomized, placebo-controlled trial with a multi-arm, parallel-group design - Phytother Res 2021 Apr 23 - "Management of prediabetes is a critical step to prevent type-2 diabetes. Curcumin and zinc have been studied as an antioxidant, antiinflammatory, and antidiabetic agents. In this clinical trial, 84 subjects were randomized into curcumin (500 mg), zinc (30 mg), zinc and curcumin, and placebo groups for 90 days ... After the intervention, dietary intake, PA, weight, and BCF% did not show a significant difference among the groups. However, subjects taking only zinc and zinc and curcumin groups experienced decreased BMI compared to the placebo (p = .01 and .007, respectively). The three treated groups had improved FPG (p = .01), 2hpp (p = .003), HbA1C (p = .004), insulin (p = .001), IS% (p = .001), and IR (p < .001) compared to the placebo. Based on these results, zinc and curcumin supplementation exerted a beneficial effect on several key glycemic parameters" - See curcumin at Amazon.com and Jarrow Zinc Balance at Amazon.com.
• Disposition of Dietary Polyphenols in Breast Cancer Patients' Tumors, and their Associated Anticancer Activity: the Particular Case of Curcumin - Mol Nutr Food Res 2021 May 3 - "Curcuminoids could be coadjuvants that might help fight BC upon regular consumption"
• Promising role of curcumin against viral diseases emphasizing COVID-19 management: A review on the mechanistic insights with reference to host-pathogen interaction and immunomodulation - J Funct Foods 2021 Jul - "Curcumin has already acknowledged immense interest from both medical and scientific research because of its multifaceted activity. To date, the promising effects of curcumin were perceived against numerous inflammatory diseases. Besides, curcumin's role as a medicine has been studied in many virus infections like influenza, HIV, etc. There is a need to analyze the cellular mechanisms of curcumin including host-pathogen interaction and immunomodulatory effects, to explore the role of curcumin against COVID-19. With this background, our study suggests that curcumin can prevent COVID-19 infections by inhibiting the pathogen entry, viral genome replication and steps in the endosomal pathway along with inhibition of T-cell signalling by impairing the autophagy-mediated antigen-presenting pathway. This review explicit the possible mechanisms behind curcumin-induced cellular immunity and a therapeutive dosage of curcumin suggesting a preventive strategy against COVID-19"
• Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol - Trials 2021 Jan 30 - "patients of knee OA were randomized to receive bioavailable turmeric extract (BCM-95®) 500 mg capsule two times daily or paracetamol 650 mg tablet three times daily for 6 weeks ... bioavailable turmeric extract is as effective as paracetamol in reducing pain and other symptoms of knee osteoarthritis and found to be safe and more effective in reducing CRP and TNF-α" - [Nutra USA] - See turmeric extract at Amazon.com.
• Neuroprotective Effect of Turmeric Extract in Combination with Its Essential Oil and Enhanced Brain Bioavailability in an Animal Model - Biomed Res Int 2021 Jan 26 - "Swiss albino mice received turmeric extract (TE), TE-essential oil combination (TE+EO) at doses of 25 and 50 mg/kg/day orally, vehicle (control), and a positive control group. Neurotoxicity was induced by injecting aluminum chloride (40 mg/kg/day, i.p.), and the effect of the intervention was studied for 45 days. The pharmacokinetic and behavioral biochemical markers of brain function and brain histopathological changes were evaluated ... The AUC 0- showed a 30.1 and 54.2 times higher free curcumin concentration in plasma with 25 mg/kg and 50 mg/kg of TE+EO vs. TE, respectively. The concentration of free curcumin in the brain was 11.01 and 13.71-fold higher for 25 mg/kg and 50 mg/kg of TE+EO vs. TE, respectively. Aluminum impairs spatial learning and memory, which was significantly reversed with TE+EO by 28.6% (25 mg/kg) and 39.4% (50 mg/kg). In the elevated plus maze test, 44.8% (25 mg/kg) and 67.1% (50 mg/kg) improvements were observed. A significant reduction in aluminum-induced lipid peroxidation was observed. Also, the levels of glutathione, acetylcholinesterase, and catalase were improved with TE+EO. Damage to the hippocampal pyramidal cells was averted with TE+EO. Conclusion. The neuroprotective and antioxidant response confirms the benefits of TE+EO against aluminum-induced neurotoxicity. The presence of free curcumin and its metabolites in the brain and plasma establishes its improved bioavailability and tissue distribution. Therefore, the benefits of TE+EO could be harnessed in neurodegenerative diseases" - [Nutra USA] - See turmeric extract at Amazon.com and turmeric extract essential oil at Amazon.com.
• Effectiveness of the piperine-supplemented Curcuma longa L. in metabolic control of patients with type 2 diabetes: a randomised double-blind placebo-controlled clinical trial - Int J Food Sci Nutr 2021 Feb 14 - "A randomised double-blind placebo-controlled clinical trial was conducted with 71 participants divided into a Curcuma longa L. group (500 mg/day with piperine 5 mg) and a placebo group, for 120 days ... The curcuma group presented a significantly decreased glycaemia (p=.013), glycated haemoglobin (p=.015), HOMA index (p=.037) and triglycerides (TGs) (p=.002). The use of piperine-added Curcuma longa L. was effective in the glycaemic and TG control of patients with type 2 diabetes" - [Nutra USA] - See curcumin at Amazon.com and piperine extract at Amazon.com.
• Efficacy of a curcumin extract (Curcugen™) on gastrointestinal symptoms and intestinal microbiota in adults with self-reported digestive complaints: a randomised, double-blind, placebo-controlled study - BMC Complement Med Ther 2021 Jan 21 - "There is preliminary evidence to suggest curcumin can alleviate digestive symptoms in adults with self-reported digestive complaints and irritable bowel syndrome ... 79 adults with self-reported digestive complaints were recruited and randomised to receive either a placebo or 500 mg of the curcumin extract, Curcugen™ ... The curcumin extract, Curcugen™, administered for 8 weeks at a dose of 500 mg once daily was associated with greater improvements in digestive complaints and anxiety levels in adults with self-reported digestive complaints" - [Nutra USA]
• Ten Days of Curcumin Supplementation Attenuates Subjective Soreness and Maintains Muscular Power Following Plyometric Exercise - J Diet Suppl 2021 Jan 22 - "Participants (n = 22; five females, 17 males) consumed either curcumin (500 mg) or placebo twice daily for 10 days (6 days pre, day of and 3 days post exercise) ... These data suggest curcumin reduces soreness and maintains muscular power following plyometric exercise" - [Nutra USA]
• Efficacy and Safety of Tetrahydrocurcuminoids for the Treatment of Canker Sore and Gingivitis - Evid Based Complement Alternat Med 2020 Dec 16 - "Tetrahydrocurcuminoids (THCs) are among the major metabolites of curcuminoids with a higher bioavailability and physiological stability and exhibit a broad spectrum of therapeutic activities ... Patients were instructed to self-administer one chewable tablet containing 100 mg of THCs twice daily for up to 21 days ... THCs treatment significantly reduced the reddening at the site, difficulty in chewing, swallowing, and VAS pain score in the canker sore patients. Further, both single and multiple lesions were completely healed. In gingivitis patients, gingival appearance, bleeding, and inflammation were significantly reduced. No adverse effects were observed during the study" - [Nutra USA]
• The effects of oral administration of curcumin–galactomannan complex on brain waves are consistent with brain penetration: a randomized, double-blinded, placebo-controlled pilot study - Nutr Neurosci 2020 Dec 9 - "curcumin-galactomannan (CGM) ... A total of 18 healthy volunteers aged 35–65 were randomly assigned to consume 500 mg CGM, Unformulated curcumin (UC) or Placebo capsules twice daily for 30 days ... Supplementation of CGM resulted in a significant increase in α- and β-waves (p < 0.05) as well as a significant reduction in α/β ratio in comparison with unformulated curcumin and placebo groups. Furthermore, the CGM showed significant reduction in the audio-reaction time (29.8 %; p < 0.05) in comparison with placebo and 24.6% (p < 0.05) with unformulated curcumin. The choice-based visual-reaction time was also significantly decreased (36%) in CGM as compared to unformulated curcumin and placebo which produced 15.36% and 5.2% respectively" - [Nutra USA] - See curcumin at Amazon.com and fenugreek at Amazon.com.
• Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin-induced testicular toxicity - Andrologia 2020 Dec 1 - "matrix metalloproteinases (MMPs) ... Male rats were randomly divided into eight groups (n = 8 per group). The groups were as follows: sham, dimethyl sulphoxide (100 µL), DOX (3 mg/kg), CAPE (2.68 mg/kg), curcumin (30 mg/kg), DOX+CAPE (3 mg/kg DOX and 2.68 mg/kg CAPE), DOX+curcumin (3 mg/kg DOX and 30 mg/kg curcumin) and DOX+CAPE+curcumin (3 mg/kg DOX, 2.68 mg/kg CAPE and 30 mg/kg curcumin) ... The results showed that MMPs mediated DOX-induced testicular injury, but CAPE and especially curcumin suppressed testis injury and cell apoptosis by suppressing DOX-induced increases in MMPs, oxidative stress and proinflammatory cytokines. However, curcumin exhibited more pronounced effects than CAPE in terms of all studied parameters" - See curcumin at Amazon.com and iHerb and caffeic acid phenethyl ester at Amazon.
  • Caffeic acid phenethyl ester - Wikipedia - "CAPE is found in a variety of plants. It is also a component of propolis from honeybee hives"
• Influence of a low-dose supplementation of curcumagalactomannoside complex (CurQfen) in knee osteoarthritis: A randomized, open-labeled, active-controlled clinical trial - Phytother Res 2020 Nov 18 - "A 6-week, randomized, open-label, active-controlled clinical trial was conducted to evaluate the influence of a low-dose curcumagalactomannosides (CGM) (400 mg once daily) in OA subjects. The treatment was compared with a standard combination of 500 mg glucosamine hydrochloride (GLN) and 415 mg chondroitin sulphate (CHN), supplied as a single oral dose twice a day. Out of 84 subjects randomized, 72 subjects who have completed the study were evaluated for the safety and efficacy of the treatments at baseline and subsequent visits (day 28 and 42), by measuring walking performance, VAS, KPS, and WOMAC scores. CGM exhibited 47.02, 21.43, and 206% improvement in VAS, KPS, and walking performance, respectively, compared to the baseline. Similarly, there was 31.17, 32.93, 36.44, and 35% improvement in the pain, stiffness, physical function, and total WOMAC scores. CGM also caused a substantial reduction in the serum inflammatory marker levels. The results indicate that a short-term supplementation of a low dosage CGM exerted superior beneficial effects than a high-dosage CHN-GLN combination in alleviating the pain and symptoms of OA subjects" - [Nutra USA] - See CurQfen at Amazon.com, curcumin at Amazon.com and iHerb and fenugreek at Amazon.com and iHerb.
• Selected root plant supplementation reduces indices of exercise-induced muscle damage: A systematic review and meta-analysis - Int J Vitam Nutr Res 2020 Nov 16 - "This systematic review and meta-analysis examined the effects of selected root plants (curcumin, ginseng, ginger and garlic) on markers of muscle damage and muscular performance measures following muscle-damaging protocols. We included 25 studies (parallel and crossover design) with 353 participants and used the PEDro scale to appraise each study ... The meta-analysis showed that the supplemental (SUPP) condition showed significantly lower levels of indirect muscle damage markers (creatine kinase, lactate dehydrogenase and myoglobin) and muscle soreness at 24 hours and 48 hours (p < 0.01) than the placebo (PLA) condition. The inflammatory markers were significantly lower for the SUPP condition than the PLA condition at 24 hours (p = 0.02), although no differences were identified at 48 hours (p = 0.40). There were no significant differences in muscular performance measures between the SUPP and PLA conditions at 24 hours and 48 hours (p > 0.05) post-exercise. According to our qualitative data, a number of studies reported a reduction in oxidative stress (e.g., malondialdehyde, superoxide dismutase) with a concomitant upregulation of anti-oxidant status, although other studies showed no effects. Accordingly, selected root plants minimised the level of several biomarkers of muscle damage, inflammation and muscle soreness during periods of exercise-induced muscle damage. However, the benefits of these supplements in ameliorating oxidative stress, increasing anti-oxidant status and accelerating recovery of muscular performance appears equivocal, warranting further research in these outcome measures" - See curcumin at Amazon.com and iHerb, ginseng at Amazon.com and iHerb and garlic supplements at Amazon.com and garlic at iHerb.com.
• The effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial - Phytother Res 2020 Nov 16 - "This study was conducted to determine the effects of curcumin intake on wound healing and metabolic status in patients with diabetic foot ulcer (DFU). The current randomized, double-blind, placebo-controlled trial was conducted among 60 patients with grade 3 DFU. Participants were randomly allocated into two groups (30 participants each group), received either 80 mg nanocurcumin daily for 12 weeks or placebo ... Curcumin intake significantly decreased fasting plasma glucose (p = .02), insulin (p = .01), insulin resistance (p = .02), and significantly increased insulin sensitivity (p = .008) compared with the placebo. Moreover, curcumin intake led to a significant reduction in total- (p < .001), LDL-cholesterol (p < .001), and a significant increase in total antioxidant capacity (TAC) (p < .001) and total glutathione (GSH) (p = .01) compared with the placebo. However, there was no significant improvement in wound healing parameters. Overall, our study demonstrated that nanocurcumin intake in patients with DFU resulted in a significant improvement of glycemic control, total- and LDL-cholesterol, TAC, and GSH but did not affect the indicators of ulcer size"
• An Exploratory Analysis of Changes in Mental Wellbeing Following Curcumin and Fish Oil Supplementation in Middle-Aged and Older Adults - Nutrients 2020 Sep 23 - "Curcumin has previously been shown to enhance mood in non-depressed older adults. However, observed benefits were limited to short-term supplementation (4 weeks). In a 16 week randomized, double-blind, placebo-controlled, 2 × 2 factorial design trial, we supplemented overweight or obese non-depressed adults (50-80 years) with curcumin (160 mg/day), fish oil (2000 mg docosahexaenoic acid +400 mg eicosapentaenoic acid/day), or a combination of both ... Curcumin improved vigour (p = 0.044) compared to placebo and reduced SMCs compared to no curcumin treatment (p = 0.038). Fish oil did not affect any mood states, SMCs or QoL; however, responses to fish oil were affected by APOE4 status. In APOE4 non-carriers, fish oil increased vigour (p = 0.030) and reduced total mood disturbances (p = 0.048) compared to placebo. Improvements in mental wellbeing were correlated with increased QoL. Combining curcumin with fish oil did not result in additive effects. This exploratory analysis indicates that regular supplementation with either curcumin or fish oil (limited to APOE4 non-carriers) has the potential to improve some aspects of mental wellbeing in association with better QoL" - [Nutra USA] - See curcumin at Amazon.com and iHerb and omega-3 supplements at Amazon.com and iHerb.
• Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK1/2 Signaling Pathway - Evid Based Complement Alternat Med 2020 Aug 7 - "The results provide new evidence for the potential anti-inflammatory and cardiovascular protective effects of curcumin"
• Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults - Antioxidants (Basel) 2020 Jul 22 - "Brain-derived neurotrophic factor (BDNF) is key for the maintenance of normal neuronal function and energy homeostasis and has been suggested to improve cognitive function, including learning and memory. Iron and the antioxidant curcumin have been shown to influence BDNF homeostasis ... Participants were randomly allocated to five different treatment groups: both iron and curcumin placebo (FS0+Plac), low dose iron and curcumin placebo (FS18+Plac), low dose iron and curcumin (FS18+Curc), high dose iron and curcumin placebo (FS65+Plac) and high dose iron and curcumin (FS65+Curc). Results showed a significant increase in BDNF over time (26%) in the FS18+Curc group (p = 0.024), and at end-point between FS18+Curc and FS18+Plac groups (35%, p = 0.042), demonstrating for the first time that the combination with curcumin, rather than iron supplementation alone, results in increased serum BDNF. The addition of curcumin to iron supplementation may therefore provide a novel approach to further enhance the benefits associated with increased BDNF levels" - [Nutra USA] - See iron supplements at Amazon.com and iHerb and curcumin at Amazon.com and iHerb.
• Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study - J Altern Complement Med 2020 Jul 14 - "A combination of curcumagalactomannosides (CGM) (400 mg) with glucosamine hydrochloride (GLN) (500 mg) was evaluated against a standard dietary supplement combination chondroitin sulfate (CHN) (415 mg)/GLN (500 mg) for their effectiveness in alleviating the pain and symptoms among osteoarthritic subjects ... CGM-GLN was found to offer significant beneficial effects to pain, stiffness, and physical function of OA subjects compared with CHN-GLN, which was evident from the improvement in walking performance, VAS score, KPS score, and WOMAC score. The efficiency of CGM-GLN was almost double compared with the CHN-GLN by the end of the study (84th day). A significant reduction of inflammatory serum marker levels was observed among CGM-GLN subjects compared with CHN-GLN subjects. Compared with the baseline, CGM-GLN produced 54.52%, 59.08%, and 22.03% reduction in IL-1β, IL-6, and sVCAM levels, respectively. Whereas CHN-GLN group of subjects expressed only 23.17%, 21.38%, and 6.82% reduction in IL-1β, IL-6, and sVCAM levels, respectively" - [Nutra USA] - See curcumin at Amazon.com and iHerb and glucosamine hydrochloride at Amazon.com and iHerb.
• Curcumin Inhibits Hepatocellular Carcinoma via Regulating miR-21/TIMP3 Axis - Evid Based Complement Alternat Med 2020 Jul 17 - "Curcumin exhibits anticancer effects against various types of cancer including hepatocellular carcinoma (HCC). miR-21 has been reported to be involved in the malignant biological properties of HCC ... Taken together, the present study suggests that miR-21 is involved in the anticancer activities of curcumin through targeting TIMP3, and the mechanism possibly refers to the inhibition of TGF-β1/smad3 signaling pathway"
• Positive effect of curcumin on experimental peridontitis via suppression of IL-1-beta and IL-6 expression level - Int J Vitam Nutr Res 2020 Jul 28 - "This study examined the effect of curcumin on T-helper (Th17) and T-regulatory (Treg) cells regarding the mRNA of cytokines/mediators in the gingiva. Thirty-five male albino Wistar rats were divided into four groups: Group 1: periodontitis (n = 9); Group 2: periodontitis with curcumin treatment (n = 8); Group 3: periodontally healthy with curcumin treatment (n = 10); and Group 4: periodontally healthy (n = 8). Curcumin was administered via oral gavage (30 mg/kg/day) for a total of 15 days ... When the periodontitis groups were compared, curcumin treatment resulted in lower IL-1β (Group 2 median: 0.002, Group 1 median: 0.12) and IL-6 (Group 2 median: 0.031, Group 1 median: 0.078) and higher IL-17 (Group 2 median: 1.07, Group 1 median: 0.583) relative mRNA expression in Group 2 than in Group 1 (p < 0.001). Group 3 also had higher IL-10 relative expression (median: 0.067) than Groups 1 and 4 (median: 0.028, 0.007, respectively. p < 0.001). These results indicate that curcumin might be a promising agent for the prevention and/or treatment of periodontal diseases due to its decreasing effect on IL-1β and IL-6 mRNA expression"
• The Role of the Curcumin for Inducing Apoptosis in Acute Lymphoblastic Leukemia Cells: A Systematic Review - Nutr Cancer 2020 Jul 13 - "Acute lymphoblastic leukemia (ALL) is a hematological malignancy of lymphoid progenitor cells associated with excessive proliferation of lymphocytes. Curcumin, a polyphenolic compound, is known to possess anticancer activity ... According to six articles that were selected, curcumin could enhance the antitumor activity of chemotherapy drugs such as L-asparaginase. Curcumin induces apoptosis in Pre B- ALL and T- ALL cells by decreased NF-kB levels, increased p53 levels, PARP-1 cleavage. Also, the induction of growth-arrest and apoptosis in association with the blockade of constitutively active JAK-STAT pathway suggests this be a mechanism by curcumin. Curcumin could be used for the treatment of cancer like ALL"
• Alterations in Systemic Inflammatory Response Following a Half-Marathon Race with a Combined Curcumin and Pomegranate Supplement: A Feasibility Study - J Diet Suppl 2020 Jul 13 - "Endurance running training can lead to gradual accumulation of inflammation and soreness ultimately resulting in overuse injuries. Management of soreness and inflammation with pharmaceuticals (i.e. non-prescription pain relievers) during long-term training is not a suitable solution due to known side effects (e.g. gastrointestinal complications, etc.). Dietary polyphenols (i.e. curcumin, pomegranate, etc.) have been purported to reduce inflammation and muscle soreness, without these negative side effects making them ideal for use in an exercise model ... Pathway classification of these biomarkers indicated supplementation may be associated with a more favorable muscle recovery profile. Our findings support the notion that combined curcumin and pomegranate supplementation may represent a useful addition to a comprehensive exercise training plan" - See curcumin at Amazon.com and iHerb and pomegranate extract at Amazon.com and iHerb.
• Combination of Curcumin and Metformin Inhibits Cell Growth and Induces Apoptosis without Affecting the Cell Cycle in LNCaP Prostate Cancer Cell Line - Nutr Cancer 2020 Jul 13 - "The viability of cells treated with curcumin, metformin, and their combination was significantly (P < 0.05) reduced with increasing the concentration and prolonging the treatment time. Meanwhile, the combination showed a synergistic effect within 48 h. In the curcumin treated group, the expression of Bcl-2 and hTERT genes diminished. In the metformin treated group, the expression of Bax and PUMA genes was enhanced while the expression of Bcl-2, hTERT, mTOR, and p53 genes declined. Although all treatments induced apoptosis, the combination of curcumin and metformin showed the maximum level of apoptosis, cytotoxicity, and expression of Bax gene. The combination of curcumin and metformin showed synergistic effects within 48 h. This combination could be a potential therapeutic candidate for prostate cancer to be further investigated" - See curcumin at Amazon.com and iHerb and metformin at ReliableRX.
• Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study - Nutrients 2020 Jun 4;12(6):E1678 - "Eighty participants aged 50–80 years (mean = 68.1, SD = 6.34) were randomised to receive Longvida© (400 mg daily containing 80 mg curcumin) or a matching placebo ... Compared with placebo, curcumin was associated with several significant effects. These included better working memory performance at 12-weeks (Serial Threes, Serial Sevens and performance on a virtual Morris Water Maze), and lower fatigue scores on the Profile of Mood States (POMS) at both 4 and 12-weeks, and of tension, anger, confusion and total mood disturbance at 4-weeks only. The curcumin group had significantly elevated blood glucose. These results confirm that Longvida© improves aspects of mood and working memory in a healthy older cohort. The pattern of results is consistent with improvements in hippocampal function and may hold promise for alleviating cognitive decline in some populations" - [Nutra USA] - See Longvida curcumin supplements at Amazon.com.
• Impact of curcumin supplementation on expression of inflammatory transcription factors in hemodialysis patients: A pilot randomized, double-blind, controlled study - Clin Nutr. 2020 Mar 13 - "Three months treatment with curcumin in CKD patients undergoing HD resulted in decreased markers of inflammation, NF-kB mRNA expression and hsCRP, suggesting that oral supplementation of curcumin may have an anti-inflammatory effect in this patient group"
• The effects of curcumin supplementation on body mass index, body weight, and waist circumference in patients with nonalcoholic fatty liver disease: A systematic review and dose-response meta-analysis of randomized controlled trials - Phytother Res. 2019 Dec 4 - "Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidity; its prevalence is elevating due to the rising epidemic of obesity ... Curcumin supplementation significantly reduced BMI (weighted mean difference [WMD] = -0.34 kg/m2 , 95% CI [-0.64, -0.04], p < .05) and WC (WMD = -2.12 cm, 95% CI [-3.26, -0.98], p < .001). However, no significant effects of curcumin supplementation on body weight were found. These results suggest that curcumin supplementation might have a positive effect on visceral fat and abdominal obesity that have been associated with NAFLD"
• Curcumin improves asthenozoospermia by inhibiting reactive oxygen species reproduction through nuclear factor erythroid 2-related factor 2 activation - Andrologia. 2019 Dec 3:e13491 - "Our results have shown that curcumin might protect spermatozoa by regulating Nrf2 level"
• Beneficial effects of nano-curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: A randomized, double-blind, placebo-controlled clinical trial - Phytother Res. 2019 Dec 1 - "Depression in patients with diabetes is associated with poor glycemic control and linked to an increased risk for diabetes complications such as neuropathy. Curcumin has shown potential antidepressant-like activities in some studies. The present study is the first randomized controlled trial to test the efficacy of nano-curcumin supplementation on depression, anxiety, and stress in patients with diabetic polyneuropathy ... Eighty patients with diabetes ... received 80 mg of nano-curcumin or placebo capsules daily for 8 weeks ... After intervention, there was a significant reduction in the mean score of depression in the nano-curcumin group (from 16.7 [3.1] to 15.3 [2.6]) compared with placebo group (17.5 [3.2] to 17.3 [3.1]; p = .02). In addition, a significant fall was found in the mean score of anxiety in the nano-curcumin group (from 22.4 [4.03] to 20.6 [3.4]) compared with the placebo group (21.9 [3.5] to 21.2 [3.5]; p = .009). Changes in stress score were not statistically significant between the two groups. These findings suggested that nano-curcumin supplementation for 8 weeks was effective in reducing depression and anxiety scores in patients with diabetic polyneuropathy" - See nano-curcumin at Amazon.com.
• Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial - J Cell Biochem. 2019 Sep;120(9):15989-15996 - "Supplementation with curcuminoids plus piperine significantly reduced the hematocrit (P = 0.027), erythrocyte sedimentation rate (P = 0.048) and the serum concentrations of alanine aminotransferase (P = 0.035), aspartate aminotransferase (P = 0.042), alkaline phosphatase (P = 0.004), cholesterol (P < 0.016), low-density lipoprotein cholesterol (P < 0.017), Iron (P = 0.026), and Hemoglobin (P = 0.025) and increased total iron-binding capacity (P = 0.003). However, except albumin, changes in other parameters were not statistically different between groups. In addition, administration of curcuminoids plus piperine significantly improved NAFLD severity (P < 0.001), which was statistically different compared with the placebo group" - [Nutra USA] - See curcumin at Amazon.com and piperine extract at Amazon.com.
• Water Extract of Curcuma longa L. Ameliorates Non-Alcoholic Fatty Liver Disease - Nutrients. 2019 Oct 21;11(10) - "Our aim was to investigate whether hot water extract (CLW) of Curcuma longa L. could prevent non-alcoholic fatty liver disease (NAFLD) ... These results suggest that CLW could be a potentially useful agent for the prevention of NAFLD through modulating fatty acid uptake"
• A Curcumin Analog Reduces Levels of the Alzheimer's Disease-Associated Amyloid-β Protein by Modulating AβPP Processing and Autophagy - J Alzheimers Dis. 2019 Oct 17 - "Curcumin is a natural compound primarily found in the widely used culinary spice, turmeric, which displays therapeutic potential for AD. Recently, we reported the development of curcumin analogs and identified a lead compound, curcumin-like compound-R17 (CLC-R17), that significantly attenuates Aβ deposition in an AD transgenic mouse model. Here, we elucidated the mechanisms of this analog on Aβ levels and AβPP processing using cell models of AD. Using biochemical methods and our recently developed nanoplasmonic fiber tip probe technology, we showed that the lead compound potently lowers Aβ levels in conditioned media and reduces oligomeric amyloid levels in the cells. Furthermore, like curcumin, the lead compound attenuates the maturation of AβPP in the secretory pathway. Interestingly, it upregulated α-secretase processing of AβPP and inhibited β-secretase processing of AβPP by decreasing BACE1 protein levels. Collectively, our data reveal mechanisms of a promising curcumin analog in reducing Aβ levels, which strongly support its development as a potential therapeutic for AD"
• Curcumin Inhibits Joint Contracture through PTEN Demethylation and Targeting PI3K/Akt/mTOR Pathway in Myofibroblasts from Human Joint Capsule - Evid Based Complement Alternat Med. 2019 Aug 14;2019:4301238 - "Joint contracture is increasingly regarded as a clinical problem that leads to irreversible dysfunction of the joint. It is a pathophysiological process following joint injury, which is marked by the activation of myofibroblasts. There is currently no effective treatment for the prevention of joint contracture ... In the present study, we demonstrated that curcumin exerts a protective effect against joint contracture via the inhibition of myofibroblast proliferation and migration in a time- and concentration-dependent manner. Moreover, we indicated that phosphatase and tension homolog (PTEN) was downregulated in myofibroblasts in vitro and in the contracture capsule tissues of patients in vivo. Additionally, western blot analysis revealed a negative correlation between the expression levels of PTEN and the fibrosis marker protein alpha smooth muscle cell actin. Methylation-specific PCR results suggested that curcumin was able to demethylate PTEN in a similar manner to the demethylation agent 5-azacytidine, increasing PTEN expression and further inhibiting phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling. In conclusion, our data illustrate part of the mechanism of curcumin inhibition in joint contracture. These results support the hypothesis that curcumin may potentially be used as a novel candidate for the treatment of joint contracture"
• Effect of Curcumin Supplementation on Exercise-Induced Oxidative Stress, Inflammation, Muscle Damage, and Muscle Soreness - J Diet Suppl. 2019 Apr 26:1-14 - "Curcumin has been shown to reduce exercise-induced oxidative stress (OS) and inflammation ... Nineteen males participated in a randomized, double-blinded, placebo-controlled trial to examine the effects of curcumin supplementation (1.5 g/day) compared to a placebo (PLA) following a muscle-damaging protocol (MDP) on OS, inflammation, muscle damage, and soreness ... After supplementation, curcumin significantly blunted CK levels (199.62 U/L) compared to the placebo (287.03 U/L), overall (p < 0.0001). In addition, curcumin resulted in decreased muscle soreness, overall (VAS scale 2.88), when compared to the placebo (VAS scale 3.36) (p = 0.0120). There were no differences found in TAC, TNF-α, or MDA. Curcumin may reduce muscle damage and perceived muscle soreness without negatively impacting a natural inflammatory response following exercise" - [Nutra USA]
• The Effect of Curcumin on Serum Copper and Zinc and Zn/Cu Ratio in Individuals with Metabolic Syndrome: A Double-Blind Clinical Trial - J Diet Suppl. 2018 Jul 18:0 - "The serum Zn/Cu level in phospholipidated curcumin and curcumin groups after intervention was higher than for the control group, but it was more significant in the group taking phospholipidated curcumin (p <.001). Curcumin and phospholipidated curcumin complex, given at a dose of 1 g per day for six weeks, were associated with an increase in serum zinc and consequently zinc-to-copper ratio"
• The effect of curcumin supplementation on circulating adiponectin: A systematic review and meta-analysis of randomized controlled trials - Diabetes Metab Syndr. 2019 Jul 30;13(5):2819-2825 - "Out of 313 records, 6 trials that enrolled 652 subjects were included. The pooled results showed that curcumin supplementation significantly increased adiponectin concentrations in comparison with placebo" - [Nutra USA]
• Eight Weeks of a High Dose of Curcumin Supplementation May Attenuate Performance Decrements Following Muscle-Damaging Exercise - Nutrients 2019, 11(7), 1692 - "Sixty-three physically active men and women (21 ± 2 y; 70.0 ± 13.7 kg; 169.3 ± 15.2 cm; 25.6 ± 14.3 body mass index (BMI), 32 women, 31 men) were randomly assigned to ingest 250 mg of CurcuWIN® (50 mg of curcuminoids), 1000 mg of CurcuWIN® (200 mg of curcuminoids), or a corn starch placebo (PLA) for eight weeks in a double-blind, randomized, placebo-controlled parallel design ... When compared to changes observed against PLA, a 200-mg dose of curcumin attenuated reductions in some but not all observed changes in performance and soreness after completion of a downhill running bout. Additionally, a 50-mg dose appears to offer no advantage to changes observed in the PLA and 200-mg groups" - [Nutra USA] - See CurcuWIN® at Amazon.com.
• A Highly Bioavailable Curcumin Extract Improves Neurocognitive Function and Mood in Healthy Older People: A 12-Week Randomised, Double-Blind, Placebo-Controlled Trial - Current Developments in Nutrition, June 2019 - "Compared with placebo, there were a number of improvements in the curcumin group. The curcumin group had significantly better working memory performance at 12 weeks, as measured by Serial Threes, Serial Sevens and performance on a virtual Morris Water Maze. Curcumin was also associated with better performance on a pattern separation task. Curcumin was also associated with significantly lower fatigue scores on the Profile of Mood States (POMS) at both 4 and 12 weeks, and of tension, anger, confusion and total mood disturbance at 4 weeks only. There were no group differences in biomarker levels" - [Nutra USA] - See Longvida™ curcumin at Amazon.com.
• The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: a randomized, placebo-controlled, double-blind trial - Nutr Neurosci. 2019 Jun 26:1-10 - "The subjects were randomly divided into four groups as (1) combination of nano-curcumin (80 mg) plus CoQ10 (300 mg), (2) nano-curcumin (80 mg), (3) CoQ10 (300 mg) and (4) the control (nano-curcumin and CoQ10 placebo included oral paraffin oil) beside usual prophylactic drugs for 8 weeks ... The results showed a significant effect of nano-curcumin and CoQ10 supplementation on frequency, severity, duration of migraine attacks and HDR compared to other groups (All P < 0.001). Nano-curcumin and CoQ10 group also had better scores in migraine-specific questionnaires at the end of the study compared to other groups (All P < 0.001). There were no side effects reported by the participants" - See curcumin products at Amazon.com and ubiquinol products at Amazon.com.
• Neuroprotective Potential of Curcumin-Loaded Nanostructured Lipid Carrier in an Animal Model of Alzheimer's Disease: Behavioral and Biochemical Evidence - J Alzheimers Dis. 2019;69(3):671-686 - "Alzheimer's disease (AD) is one of the most common neurodegenerative diseases and is caused by accumulation of amyloid-β (Aβ) peptide and is associated with neurological abnormalities in learning and memory. The protective role of curcumin on nerve cells, along with a potent antioxidant and free radical scavenging activity, has been widely studied. However, its low bioavailability and limited transport ability across the blood-brain barrier are two major drawbacks of its application in the treatment of different neurodegenerative diseases. The present study was designed to improve the effectiveness of curcumin in the treatment of Aβ-induced cognitive deficiencies in a rat model of AD by loading it into nanostructured lipid carriers (NLCs) ... The result of studying the neuroprotective potential of Cur-NLC in both pre-treatment and treatment modes showed that loading curcumin in NLCs is an effective strategy for increasing curcumin delivery to the brain and reducing Aβ-induced neurological abnormalities and memory defects and that it can be the basis for further studies in the area of AD prevention and treatment"
• Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled clinical trial - Eur J Nutr. 2019 Feb 22 - "Subjects were randomized to be treated with indistinguishable tablets (2 per day, to be taken after dinner) containing 800 mg phytosomal curcumin (Curserin®: 200 mg curcumin, 120 mg phosphatidylserine, 480 mg phosphatidylcholine and 8 mg piperine from Piper nigrum L. dry extract) for 8 weeks ... After 56-day treatment, the curcumin-treated group experienced a significant improvement in fasting plasma insulin (FPI), HOMA index, waist circumference, blood pressure, triglycerides (TG), HDL-C, liver transaminases, gamma-GT, index of liver steatosis and serum cortisol compared to the baseline. FPI, TG, liver transaminases, fatty liver index and serum cortisol level also significantly improved compared with the placebo-treated group. Compared to the baseline, at the end of the study placebo group experienced an improvement only in FPG and TG ... supplementation with a phytosomal preparation of curcumin containing phosphatidylserine and piperine could improve glycemic factors, hepatic function and serum cortisol levels in subjects with overweight and impaired fasting glucose" - [Nutra USA] - See curcumin products at Amazon.com, phosphatidylserine at Amazon.com, phosphatidylcholine at Amazon.com and piperine extract at Amazon.com.
• The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial - Phytother Res. 2019 Mar 12 - "Curcumin, which is a natural polyphenol found in turmeric, can be used in treatment of diabetes complications for its antidiabetic, anti-inflammatory, and antioxidant properties ... Patients consumed either 1,500-mg curcumin or placebo daily for 10 weeks ... The mean serum level of TG decreased in curcumin group compared with baseline (109 ± 36 vs. 124 ± 36; p < 0.05). At the end of study, the mean concentration of high-sensitivity C-reactive protein decreased in the curcumin group compared to the control (2.9 ± 2.9 vs. 3.4 ± 4.2; p < 0.05). The mean serum concentration of adiponectin increased (64 ± 3 vs. 63 ± 4; p < 0.05) in the treatment group compared with the placebo at the end of the study. The results of the current study indicate that curcumin consumption may reduce diabetes complications through decreasing TG level as well as indicators of inflammation"
• Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial - Nutrition & Metabolism 2019 16:8 - "We aimed to determine the effects of nano-curcumin (NC) on overweight/obese NAFLD patients by assessing glucose, lipids, inflammation, insulin resistance, and liver function indices, especially through nesfatin ... randomly divided into two equal NC (n = 42) and placebo (n = 42) groups. Interventions were two 40 mg capsules/day after meals for 3 months ... NC compared with placebo significantly increased HDL, QUICKI, and nesfatin and decreased fatty liver degree, liver transaminases, waist circumference (WC), FBS, FBI, HbA1c, TG, TC, LDL, HOMA-IR, TNF-α, hs-CRP, and IL-6 (P < 0.05). The mean changes in weight, BMI, body composition (BC), and blood pressure were not significant (P > 0.05)" - [Nutra USA] - See nano-curcumin at Amazon.com.
• Influence of enhanced bioavailable curcumin on obesity-associated cardiovascular disease risk factors and arterial function: a double-blind, randomized-controlled trial - Nutri 11 Jan 19 - "The objective of this study was to determine if an enhanced bioavailable curcumin formulation, CurQfen®, would improve circulating cardiovascular disease (CVD)-related blood biomarkers and arterial function in young (18-35 years old), obese (BMI ≥ 30.0 kg/m2) men ... Subjects were matched based on BMI and randomized to the intervention (curcumin formulated with fenugreek soluble fiber, for enhanced absorption) or control (fenugreek soluble fiber) group for 12 weeks at 500 mg/day without dietary modification or exercise ... Our data provide evidence for an enhanced bioavailable curcumin to improve homocysteine and HDL concentrations, which may promote favorable cardiovascular health in young, obese men. Improvements in endothelial function or blood pressure were not observed with curcumin supplementation, warranting further investigation" - [Nutra USA} - See CurQfen® at Amazon.com.
• Does turmeric/curcumin supplementation improve serum alanine aminotransferase and aspartate aminotransferase levels in patients with nonalcoholic fatty liver disease? A systematic review and meta-analysis of randomized controlled trials - Phytother Res. 2019 Jan 17 - "Results from pooled analysis revealed that turmeric/curcumin supplementation reduced ALT (MD: -7.31 UL/L, 95% CI [-13.16, -1.47], p = 0.014) and AST (MD: -4.68 UL/L, 95% CI [-8.75 -0.60], p = 0.026). When RCTs stratified on the basis of their treatment duration, the significant reduction in serum concentrations of ALT and AST was observed only in studies lasting less than 12 weeks. This review suggests that turmeric/curcumin might have a favorable effect on serum concentrations of ALT and AST in patients with NAFLD"
• Curcumin intervention for cognitive function in different types of people: A systematic review and meta-analysis - Phytother Res. 2018 Dec 21 - "For older adults who received curcumin, scores on measures of cognitive function (SMD = 0.33, 95% confidence interval [CI] [0.05, 0.62]; p = 0.02), occurrence of adverse events (odds ratio [OR] = 5.59, 95% CI [0.96, 36.80]; p = 0.05), and measures of depression (SMD = -0.29, 95% CI [0.64, 0.05]; p = 0.09) indicated significant memory improvement"
• Curcumin promotes burn wound healing in mice by upregulating caveolin-1 in epidermal stem cells - Phytother Res. 2018 Nov 20 - "Curcumin treatment promoted the proliferative ability of ESCs and conditioned medium from curcumin-treated ESCs enhanced human umbilical vein endothelial cell (HUVEC) tube formation. We also found curcumin treatment elevated caveolin-1 expression in ESCs, which was required for the beneficial effect of curcumin on ESC proliferation and HUVEC tube formation. Next, using a mouse model of burn wound healing, curcumin-treated ESCs exhibited enhanced wound closure, which also required caveolin-1 expression. Our current study demonstrates the beneficial effect of curcumin on burn wound healing in mice, which is mediated by upregulating caveolin-1 in ESCs, and supports the potential therapeutic role of curcumin in ESC-based treatment against skin wound healing" - See curcumin products at Amazon.com.
• The protective role of melatonin and curcumin in the testis of young and aged rats - Andrologia. 2018 Nov 22:e13203 - "Aged Melatonin (MLT; n = 6, 10 mg/kg, s.c.); (d) Aged Curcumin (CUR; n = 6, 30 mg/kg, i.p.). At the end of 21 days, the rats were sacrificed, and testicular tissues were removed. Malondialdehyde (MDA) in the testicular tissue was determined with thiobarbituric acid reactive substances formation, and glutathione (GSH) was determined with modified Ellman method; testosterone level was determined with chemiluminescence method and histologic changes were determined with Haematoxylin-Eosin and Johnsen's scoring; Apoptotic cell counts were made with TUNEL staining of seminiferous tubule in testis. With ageing, MDA level increased in testicular tissue, but GSH and blood testosterone levels decreased. Melatonin treatment for aged rats significantly decreased Paired total testicular/body weight ratio compared to aged control group (p < 0.05). Curcumin treatment for aged rats significantly increased GSH level compared to the aged control group (p < 0.05). Besides, melatonin and curcumin treatment significantly decreased the number of apoptotic cells and significantly increased Johnsen's score" - See melatonin at Amazon.com.
• The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials - Phytother Res. 2018 Nov 7 - "Overall, this meta-analysis suggests that taking curcumin-containing supplements may exert anti-inflammatory and antioxidant properties through a significant reduction in IL-6, hs-CRP, and MDA levels"
• Effects of Turmeric and Curcumin Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study - J Evid Based Integr Med. 2018 Jan-Dec;23:2515690X18790725 - "Turmeric tablets with extract of piperine (Bioperine) (n = 6), curcumin with Bioperine tablets (n = 5), or placebo tablets (n = 3) were provided to healthy human subjects and subsequent changes in the gut microbiota were determined by 16S rDNA sequencing ... All participants' microbiota displayed significant variation over time and individualized response to treatment. Among the responsive participants, both turmeric and curcumin altered the gut microbiota in a highly similar manner, suggesting that curcumin may drive the majority of observed changes observed in turmeric-treated subjects" - [Nitra USA]
• The Effect of Curcumin on Serum Copper and Zinc and Zn/Cu Ratio in Individuals with Metabolic Syndrome: A Double-Blind Clinical Trial - J Diet Suppl. 2018 Jul 18:0 - "Curcumin and phospholipidated curcumin complex, given at a dose of 1 g per day for six weeks, were associated with an increase in serum zinc and consequently zinc-to-copper ratio"
• Curcumin in epilepsy disorders - Phytother Res. 2018 Jun 19 - "The molecule has an anti-seizure potential in preclinical studies, including chemical and electrical models of acute and chronic epilepsy. Curcumin also possesses an anti-epileptogenic activity as it reduces spontaneous recurrent seizures severity in a kainate model of temporal lobe epilepsy. The antioxidant and anti-inflammatory nature of curcumin might be responsible for its observed anti-seizure effects; nevertheless, the exact mechanism is not yet clear. The poor availability of curcumin to the brain limits its use in clinics. The application of nanoliposome and liposome technologies has been tested to enhance its brain availability and penetrability. Unfortunately, there are no randomized, double-blinded controlled clinical trials validating the use of curcumin in epilepsy. The present article analyzes different preclinical evidence illustrating the effect of curcumin in seizure models. The review encourages carrying out clinical trials in this important area of research. In conclusion, curcumin might be beneficial in patients with epilepsy disorders, if its bioavailability issues are resolved" - See curcumin products at Amazon.com.
• Conversion of curcumin into heterocyclic compounds as potent anti-diabetic and anti-histamine agents - Biol Pharm Bull. 2018 Apr 12 - "Our results concluded that Curcumin pyrmidinones and pyranone derivatives have highly effects as anti-diabetic and anti-histamine activities" - See curcumin products at Amazon.com.
• Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1β - Nutr Metab (Lond). 2018 Feb 6;15:12 - "It is plausible that supplementing the high fat diet of CR mice with Cur + Pip may increase loss of body fat and suppresses HFD induced inflammation. Combination of Cur and Pip has potential to enhance CR effects for the prevention of metabolic syndrome" - [Nutra USA] - See curcumin products at Amazon.com and piperine extract at Amazon.com.
• Effect of Curcumin on Anthropometric Measures: A Systematic Review on Randomized Clinical Trials - J Am Coll Nutr. 2018 Jan 9:1-8 - "It seems that the bioavailable form of curcumin can reduce obesity and overweight" - See curcumin products at Amazon.com.
• Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial - Metabolism. 2017 Dec 29 - "The addition of curcumin to phytosterol therapy provides a complementary cholesterol-lowering effect that is larger than phytosterol therapy alone. Implications of these findings include the development of a single functional food containing both the active ingredients for enhanced lipid-lowering and compliance in hypercholesterolaemic individuals" - See curcumin products at Amazon.com.
• Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway - Biochem Biophys Res Commun. 2017 Sep 4 - "Altogether, these data suggested that curcumin inhibited the activities of BCSCs through suppressing Shh pathway, which might be an effective chemopreventive agent for bladder cancer intervention"
• The Effects of Curcumin on Wound Healing in a Rat Model of Nasal Mucosal Trauma - Evid Based Complement Alternat Med. 2017;2017:9452392 - "curcumin reduced the inflammatory response and significantly accelerated wound healing"
• Effects of curcumin on short-term spatial and recognition memory, adult neurogenesis and neuroinflammation in a streptozotocin-induced rat model of dementia of Alzheimer's type - Behav Brain Res. 2017 Aug 8 - "These results suggest a positive effect of curcumin in object recognition memory which was not related to hippocampal neurogenesis"
• Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial - Complementary Therapies in Medicine, Aug 2017 - "In this 12-week randomized double-blind placebo-controlled trial, subjects with T2D (n = 118) were assigned to curcuminoids (1000 mg/day plus piperine 10 mg/day) or placebo plus standard of care for T2D ... Between-group comparison of change in the study parameters revealed significant reductions in serum levels of TC (−21.86 ± 25.78 versus −17.06 ± 41.51, respectively; p = 0.023), non-HDL-C (−23.42 ± 25.13 versus −16.84 ± 41.42, respectively; p = 0.014) and Lp(a) (−1.50 ± 1.61 versus −0.34 ± 1.73, respectively; p = 0.001) and elevations in serum HDL-C levels (1.56 ± 4.25 versus −0.22 ± 4.62, respectively; p = 0.048) in the curcuminoids group as compared with the placebo group (p < 0.05)" - [Nutra USA] - See curcumin products at Amazon.com and piperine extract at Amazon.com.
• Turmeric Supplementation Improves Serum Glucose Indices and Leptin Levels in Patients with Nonalcoholic Fatty Liver Diseases - J Am Coll Nutr. 2017 Apr 26:1-7 - "Turmeric consumption decreased serum levels of glucose, insulin, HOMA-IR and leptin (by 1.22, 17.69, 19.48 and 21.33% respectively, p < 0.05 for all) over 12 weeks compared with those variables in the placebo group" - See curcumin products at Amazon.com.
• Curcumin Reduces Muscle Damage and Soreness Following Muscle-Damaging Exercise - FASEB Journal, Apr 2017 - "The antioxidant curcumin is able to counteract the two leading causes of muscle damage, oxidative stress and inflammation, as it interacts with multiple inflammatory pathways ... randomly assigned to ingest 50 mg Curcuminoids (in the form of 250 mg CurcuWIN®), 200 mg Curcuminoids (in the form of 1,000 mg CurcuWIN®), or placebo (PLA) for eight weeks ... These data demonstrate curcuminoids reduce muscle damage and improve muscle soreness in healthy young subjects following a bout of muscle damaging exercise. Faster recovery allows for consistent training at competition intensity and might lead to enhanced adaptation rate and performance" - [Nutra USA] - See CurcuWIN® at Amazon.com.
• Curcumin Inhibits Apoptosis of Chondrocytes through Activation ERK1/2 Signaling Pathways Induced Autophagy - Nutrients. 2017 Apr 21;9(4) - "Evidence from several recent in vitro studies suggests that curcumin may exert a chondroprotective effect through actions such as anti-inflammatory, anti-oxidative stress, and anti-catabolic activity that are critical for mitigating OA disease pathogenesis and symptoms ... Our results suggest that curcumin suppresses apoptosis and inflammatory signaling through its actions on the ERK1/2-induced autophagy in chondrocytes. We propose that curcumin should be explored further for the prophylactic treatment of osteoarthritis in humans and companion animals"
• Curcumin and Viscum album Extract Decrease Proliferation and Cell Viability of Soft-Tissue Sarcoma Cells: An In Vitro Analysis of Eight Cell Lines Using Real-Time Monitoring and Colorimetric Assays - Nutr Cancer. 2017 Jan 3:1-12 - "Viscum album extract (VAE) ... soft-tissue sarcoma (STS) cells ... Curcumin and VAE can inhibit the proliferation and viability of STS cells"  - See Curcumin products at Amazon.com and Viscum album extract at Amazon.com.
• Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study - J Affect Disord. 2017 Jan 1;207:188-196 - "123 individuals with major depressive disorder were allocated to one of four treatment conditions, comprising placebo, low-dose curcumin extract (250mg b.i.d.), high-dose curcumin extract (500mg b.i.d.), or combined low-dose curcumin extract plus saffron (15mg b.i.d.) for 12 weeks ... Active drug treatments comprising differing doses of curcumin and combined curcumin/saffron were effective in reducing depressive and anxiolytic symptoms in people with major depressive disorder" - [Nutra USA] - See saffron at Amazon.com and curcumin products at Amazon.com.
• Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases - Br J Pharmacol. 2016 Sep 17 - "At the molecular level, this multitargeted agent has been shown to exhibit anti-inflammatory activity through the suppression of numerous cell signalling pathways including NF-κB, STAT3, Nrf2, ROS and COX-2. Numerous studies have indicated that curcumin is a highly potent antimicrobial agent and has been shown to be active against various chronic diseases including various types of cancers, diabetes, obesity, cardiovascular, pulmonary, neurological and autoimmune diseases. Furthermore, this compound has also been shown to be synergistic with other nutraceuticals such as resveratrol, piperine, catechins, quercetin and genistein. To date, over 100 different clinical trials have been completed with curcumin, which clearly show its safety, tolerability and its effectiveness against various chronic diseases in humans"
• Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study - J Nutr Metab. 2016;2016:1089653 - "In apparently healthy adults, 8 weeks of 200 mg oral curcumin supplementation resulted in a clinically meaningful improvement in endothelial function as measured by FMD. Oral curcumin supplementation may present a simple lifestyle strategy for decreasing the risk of cardiovascular diseases" - [Nutra USA]
• A Study on Neuroprotective Effects of Curcumin on the Diabetic Rat Brain - J Nutr Health Aging. 2016;20(8):835-840 - "Taking all these data together, the curcumin found to be effective against oxidative stress and glutamate neurotoxicity in the male albino rats"
• Curcumin, The Golden Nutraceutical: Multitargeting for Multiple Chronic Diseases - Br J Pharmacol. 2016 Sep 17 - "Numerous studies have indicated that curcumin is a highly potent antimicrobial agent and has been shown to be active against various chronic diseases including various types of cancers, diabetes, obesity, cardiovascular, pulmonary, neurological and autoimmune diseases. Further, this compound has also been shown to be synergistic with other nutraceuticals such as resveratrol, piperine, catechins, quercetin, and genistein"
• Curcumin AntiCancer Studies in Pancreatic Cancer - Nutrients. 2016 Jul 16;8(7) - "Several preclinical studies have demonstrated that curcumin, a naturally occurring polyphenolic compound, has anticancer effects against different types of cancer, including PC, by modulating many molecular targets. Regarding PC, in vitro studies have shown potent cytotoxic effects of curcumin on different PC cell lines including MiaPaCa-2, Panc-1, AsPC-1, and BxPC-3. In addition, in vivo studies on PC models have shown that the anti-proliferative effects of curcumin are caused by the inhibition of oxidative stress and angiogenesis and are due to the induction of apoptosis"
• Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial - Phytother Res. 2016 Jun 8 - "patients with ultrasonographic evidence of NAFLD were randomly assigned to receive an amorphous dispersion curcumin formulation (500 mg/day equivalent to 70-mg curcumin) or matched placebo for a period of 8 weeks ... Compared with placebo, curcumin was associated with a significant reduction in liver fat content (78.9% improvement in the curcumin vs 27.5% improvement in the placebo group). There were also significant reductions in body mass index and serum levels of total cholesterol, low-density lipoprotein cholesterol, triglycerides, aspartate aminotransferase, alanine aminotransferase, glucose, and glycated hemoglobin compared with the placebo group. Curcumin was safe and well tolerated during the course of trial" - See curcumin products at Amazon.com.
• Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence - Phytother Res. 2016 May 23 - "Overall, there is early evidence that turmeric/curcumin products and supplements, both oral and topical, may provide therapeutic benefits for skin health"
• Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals - FASEB Journal Apr 2016 - "CurcuWIN®, a novel curcumin formulation containing 20% curcuminoids (CUR), resulted in 45.9 fold greater absorption over standard curcumin ... Fifty-nine moderately trained men (n=30; 21±2 years; 173.8±20.0 cm; 79.4±11.0 kg) and women (n=29; 21±2 years; 164.9±6.5 cm; 60.1±8.0 kg) were randomly assigned to ingest 50 mg CUR (in the form of 250 mg CurcuWIN®), 200 mg CUR (in the form of 1000 mg CurcuWIN®), or placebo (PLA) for eight weeks ... These data demonstrate 200mg CUR improves FMD (endothelial function) in healthy young subjects. Further, in those with baseline FMD ≤7% FMD (at risk) 50mg CUR and 200mg CUR improves endothelial function. Given every 1% increase in FMD reduces cardiovascular disease risk by 9–17%; further research in clinical populations is recommended to clarify the true nature of the effect and potential mechanism(s)" - [Nutra USA] - See CurcuWIN® at Amazon.com.
• Safety, Tolerance, and Enhanced Efficacy of a Bioavailable Formulation of Curcumin With Fenugreek Dietary Fiber on Occupational Stress: A Randomized, Double-Blind, Placebo-Controlled Pilot Study - J Clin Psychopharmacol. 2016 Apr 2 - "CurQfen (curcumagalactomannoside [CGM]), a food-grade formulation of natural curcumin with fenugreek dietary fiber that has shown to possess improved blood-brain-barrier permeability and tissue distribution in rats. In this randomized double-blinded and placebo-controlled trial, 60 subjects experiencing occupational stress-related anxiety and fatigue were randomized to receive CGM, standard curcumin, and placebo for 30 days (500 mg twice daily). The study demonstrated the safety, tolerance, and enhanced efficacy of CGM in comparison with unformulated standard curcumin. A significant improvement in the quality of life (P < 0.05) with considerable reduction in stress (P < 0.001), anxiety (P < 0.001), and fatigue (P < 0.001) was observed among CGM-treated subjects as compared with the standard curcumin group, when monitored by SF-36, Perceived Stress Scale with 14 items, and Beck Anxiety Inventory scores. Improvement in the quality of life was further correlated with the significant enhancement in endogenous antioxidant markers (P < 0.01) and reduction in lipid peroxidation (P < 0.001). Further comparison of the free curcuminoids bioavailability after a single-dose (500 mg once per day) and repeated-dose (500 mg twice daily for 30 days) oral administration revealed enhanced absorption and improved pharmacokinetics of CGM upon both single- (30.7-fold) and repeated-dose (39.1-fold) administrations" - [Nutra USA] - See CurQfen at Amazon.com.
• Effects of Supplementation with Curcumin on Serum Adipokine Concentrations: A Randomized Controlled Trial - Nutrition, Mar 2016 - "randomly assigned to curcumin (n=59; 1000 mg/day) or placebo (n=58) for 8 weeks ... Eight-week supplementation with curcumin was associated with a significant increase in serum adiponectin levels (p<0.001), and a reduction in serum leptin concentrations (p<0.001). Serum leptin:adiponectin ratio was also improved by curcumin (p<0.001). These beneficial effects of curcumin remained significant after adjustment for changes in serum lipids and glucose concentrations, and baseline differences in BMI and serum levels of glucose and HbA1c as potential confounders of treatment response. Meta-analysis suggested that curcumin supplementation can increase adiponectin levels by 76.78% (95% CI: 6.14, 147.42; p=0.0330), and reduce leptin by 26.49%" - [Nutra USA]
• Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin - BBA Clinical Jun 16 - "The purpose of this study was to determine the effects of oral curcumin supplementation (Longvida® 400 mg/days) on muscle & ADL soreness, creatine kinase (CK), and inflammatory cytokines (TNF-α, IL-6, IL-8, IL-10) following EMID (eccentric-only dual-leg press exercise) ... Curcumin supplementation resulted in significantly smaller increases in CK (− 48%), TNF-α (− 25%), and IL-8 (− 21%) following EIMD compared to placebo ... The observed improvements in biological inflammation may translate to faster recovery and improved functional capacity during subsequent exercise sessions" - [NutraUSA]
• Curcumin Rescues Diabetic Renal Fibrosis by Targeting Superoxide-Mediated Wnt Signaling Pathways - Am J Med Sci. 2016 Mar;351(3):286-95 - "Curcumin alleviated extracellular matrix accumulation in diabetic nephropathy by not only preventing the diabetes-mediated superoxide synthesis but also resuming downregulation of Wnt/β-catenin signaling. These findings suggest that regulation of Wnt activity by curcumin is a feasible alternative strategy to rescue diabetic renal injury" - See curcumin products at Amazon.com.
• Curcumin improves tau-induced neuronal dysfunction of nematodes - Neurobiol Aging. 2016 Mar;39:69-81 - "Tau is a key protein in the pathogenesis of various neurodegenerative diseases, which are categorized as tauopathies. Because the extent of tau pathologies is closely linked to that of neuronal loss and the clinical symptoms in Alzheimer's disease, anti-tau therapeutics, if any, could be beneficial to a broad spectrum of tauopathies ... These data indicate that curcumin improves the tau-induced neuronal dysfunction that is independent of insoluble aggregates of tau"
• Neuroprotective effects of curcumin on endothelin-1 mediated cell death in hippocampal neurons - Nutr Neurosci. 2015 Dec 12 - "Curcumin, the main ingredient of the spice turmeric, has been shown to have anti-inflammatory, anti-cancer, and neuroprotective effects ... Our data suggests that one mechanism by which curcumin protects against ET-1-mediated cell death is through blocking an increase in c-Jun levels. Other possible mechanisms include decreasing pro-apoptotic signaling activated by ET-1 in primary hippocampal neurons"
• The Role of Curcumin Administration in Patients with Major Depressive Disorder: Mini Meta-Analysis of Clinical Trials - Phytother Res. 2015 Nov 27 - "Several studies have demonstrated that curcumin, the yellow-pigmented substance of the turmeric, possesses antidepressant properties ... Overall, curcumin administration showed a significantly higher reduction in depression symptoms [SMD = -0.34; 95% confidence interval (CI) = -0.56, -0.13; p = 0.002]. Subgroup analyses showed that curcumin had the highest effect when given to middle-aged patients (SMD = -0.36; 95% CI = -0.59; -0.13; p = 0.002), for longer duration of administration (SMD = -0.40; 95% CI = -0.64, -0.16; p = 0.001), and at higher doses (SMD = -0.36; 95% CI = -0.59, -0.13; p = 0.002). The administration of new formulation of curcumin (BCM-95) had non-significantly higher effect on depression as compared with the conventional curcumin-piperine formula"
• Curcumin induces apoptosis by inhibiting sarco/endoplasmic reticulum ca2+ ATPase activity in ovarian cancer cells - Cancer Lett. 2015 Nov 19 - "Curcumin induced apoptosis in ovarian cancer cells in a concentration- and time- dependent manner"
• Curcumin Suppresses Phthalate-induced Metastasis and the Proportion of CSCs-like via the Inhibition of AhR/ERK/SK1 Signaling in Hepatocellular Carcinoma - J Agric Food Chem. 2015 Nov 20 - "Our results suggest that curcumin may be a potential antidote for phthalate-induced cancer progression"
• New Antiglycative Compounds from Cumin (Cuminum cyminum) Spice - J Agric Food Chem. 2015 Nov 7 - "At equivalent concentrations, several of the isolates, including cuminoids C-E, were more potent inhibitors than the positive control, aminoguanidine, a synthetic antiglycative agent (>50 vs. 35%, respectively)" - See aminoguanidine at IAS.  See curcumin products at Amazon.com.
• Curcumin Modulates Muscle Damage but not Oxidative Stress and Antioxidant Defense Following Eccentric Exercise in Rats - Int J Vitam Nutr Res. 2014;84(3-4) - "The results of this study suggest that curcumin has a protective effect on eccentric exercise induced muscle damage, and that this effect might be independent of oxidative stress and antioxidant systems"
• Curcumin inhibits lymphangiogenesis in vitro and in vivo - Mol Nutr Food Res. 2015 Aug 27 - "Curcumin, a dietary compound from turmeric, has potent antimetastatic effects ... The aim of this study is to investigate the effects and mechanisms of curcumin on lymphangiogenesis (formation of new lymphatic vessels), which plays a critical role in tumor metastasis ... Our results demonstrate that curcumin inhibits lymphangiogenesis in vitro and in vivo, which could contribute to the antimetastatic effects of curcumin"
• Curcumin treatment enhances the effect of exercise on mitochondrial biogenesis in skeletal muscle by increasing cAMP levels - Metabolism. 2015 Jul 21 - "endurance training (eTR) ... Taken together, these results suggest that the combination of curcumin treatment and eTR has the potential to accelerate mitochondrial biogenesis in skeletal muscle by increasing cAMP levels"
• Curcumin prophylaxis mitigates the incidence of hypobaric hypoxia-induced altered ion channel expression and impaired tight junction protein integrity in rat brain - J Neuroinflammation. 2015 Jun 6 - "The present study was proposed to elucidate the prophylactic role of curcumin in the prevention of hypoxia-induced cerebral edema (HACE) ...These results indicate that curcumin is a potent drug in amelioration of HACE as it effectively attenuated inflammation as well as fluid influx by maintaining the tight junction protein integrity with increased ion channel expression in the brain of rats under hypoxia"
• Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy - Cancer Lett. 2015 May 12 - "Here, we utilised patient-derived colorectal liver metastases (CRLM) to assess whether curcumin may provide added benefit over 5-fluorouracil (5-FU) and oxaliplatin (FOLFOX) in cancer stem cell (CSC) models ... Curcumin alone and in combination, significantly reduced spheroid number in CRLM CSC models, and decreased the number of cells with high aldehyde dehydrogenase activity (ALDH(high)/CD133(-)). Addition of curcumin to oxaliplatin/5-FU enhanced anti-proliferative and pro-apoptotic effects in a proportion of patient-derived explants, whilst reducing expression of stem cell-associated markers ALDH and CD133"
• Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders - Biochim Biophys Acta. 2015 May;1852(5):951-61 - "these data suggest that curcumin enhances DHA synthesis, resulting in elevated brain DHA content. These findings have important implications for human health and the prevention of cognitive disease, particularly for populations eating a plant-based diet or who do not consume fish, a primary source of DHA, since DHA is essential for brain function and its deficiency is implicated in many types of neurological disorders" - [Nutra USA] - See curcumin products at Amazon.com and Jarrow Max DHA at Amazon.com.
• Curcumin attenuates cardiomyocyte hypertrophy induced by high glucose and insulin via the PPARγ/Akt/NO signaling pathway - Diabetes Res Clin Pract. 2015 Feb 21 - "The results suggested that curcumin supplementation can improve HGI-induced cardiomyocytes hypertrophy in vitro through the activation of PPARγ/Akt/NO signaling pathway"
  • Cardiac Hypertrophy - cts.usc.edu - "Cardiac hypertrophy is a thickening of the heart muscle (myocardium) which results in a decrease in size of the chamber of the heart, including the left and right ventricles. A common cause of cardiac hypertrophy is high blood pressure (hypertension) and heart valve stenosis"
• Effect of Curcumin Supplementation on Physiological Fatigue and Physical Performance in Mice - Nutrients. 2015 Jan 30;7(2):905-921 - "Curcumin (CCM) ... CCM supplementation dose-dependently increased grip strength and endurance performance and significantly decreased lactate, ammonia, BUN, AST, ALT, and CK levels after physical challenge. Muscular glycogen content, an important energy source for exercise, was significantly increased. CCM supplementation had few subchronic toxic effects. CCM supplementation may have a wide spectrum of bioactivities for promoting health, improving exercise performance and preventing fatigue"
• Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis - Clin Nutr. 2015 Jan 7 - "Supplementation with curcuminoid-piperine combination significantly improved serum SOD activities (p < 0.001) and reduced MDA (p < 0.001) and CRP (p < 0.001) concentrations compared with placebo. Quantitative data synthesis revealed a significant effect of curcuminoids vs. placebo in reducing circulating CRP concentrations (weighed mean difference: -2.20 mg/L; 95% confidence interval [CI]: -3.96, -0.44; p = 0.01). This effect was robust in sensitivity analysis" - See curcumin products at Amazon.com and piperine extract at Amazon.com.
• Curcumin promotes apoptosis by activating the p53-miR-192-5p/215-XIAP pathway in non-small cell lung cancer - Cancer Lett. 2014 Nov 18 - "Taken together, this study highlights that the proapoptotic effects of curcumin depend on miR-192-5p/215 induction and the p53-miR-192-5p/215-XIAP pathway is an important therapeutic target for non-small cell lung cancer"
• Curcumin Combined with Oxaliplatin Effectively Suppress Colorectal Carcinoma in vivo Through Inducing Apoptosis - Phytother Res. 2014 Nov 24 - "Combinatorial administration of curcumin and oxaliplatin evidently inhibited the growth of colorectal cancer in nude mice, which was significantly more effective than either agent alone"
• Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population - J Psychopharmacol. 2014 Oct 2 - "This randomized, double-blind, placebo-controlled trial examined the acute (1 and 3 h after a single dose), chronic (4 weeks) and acute-on-chronic (1 and 3 h after single dose following chronic treatment) effects of solid lipid curcumin formulation (400 mg as Longvida®) on cognitive function, mood and blood biomarkers in 60 healthy adults aged 60-85. One hour after administration curcumin significantly improved performance on sustained attention and working memory tasks, compared with placebo. Working memory and mood (general fatigue and change in state calmness, contentedness and fatigue induced by psychological stress) were significantly better following chronic treatment. A significant acute-on-chronic treatment effect on alertness and contentedness was also observed. Curcumin was associated with significantly reduced total and LDL cholesterol and had no effect on hematological safety measures" - [Nutra USA] - See Longvida products at Amazon.com and curcumin products at Amazon.com.
• Curcumin enhances parental reproductive lifespan and progeny viability in Drosophila melanogaster - Age (Dordr). 2014 Oct;36(5):9702 - "We have used the well-established model organism, Drosophila melanogaster, and ascertained the consequence of diet supplementation with curcumin. Flies reared on curcumin-supplemented diet had significantly higher lifespan. The progeny of flies reared on curcumin had a higher viability. The activity of a key mitochondrial enzyme-aconitase was significantly higher in flies reared on curcumin-supplemented diet. The results suggest that curcumin can not only correct a key step in the citric acid cycle and help in the release of additional energy but also permanently correct developmental and morphogenetic processes"
• Curcumin enhances cell-surface LDLR level and promotes LDL uptake through down-regulation of PCSK9 gene expression in HepG2 cells - Mol Nutr Food Res. 2014 Aug 27 - "Curcumin exhibits hypolipidemic activity and may serve as a useful supplement to statin treatment for hypercholesterolemia"
• Lipid-Lowering Effects of Curcumin in Patients with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial - Phytother Res. 2014 Aug 6 - "Sixty-five patients were randomized into two groups; 33 patients taking curcumin extract capsule (630 mg thrice daily) and 32 patients taking a placebo capsule thrice daily for 12 weeks. At 12 weeks after the curcumin extract consumption, the level of high-density lipoprotein cholesterol (HDL-C) significantly increased from 40.96 ± 8.59 to 43.76 ± 2.79 mg/dL (p < 0.05), and the level of low-density lipoprotein cholesterol (LDL) was significantly reduced (120.55 ± 36.81 to 106.51 ± 25.02 mg/dL, p < 0.05). The triglyceride-lowering effect, a reduction of 65 mg/dL, was also found in this study" - See curcumin products at Amazon.com.
• The effects of curcumin on depressive-like behavior in mice after lipopolysaccharide administration - Behav Brain Res. 2014 Aug 14 - "we examined the effects of curcumin on lipopolysaccharide (LPS)-induced depressive-like behavior and inflammation in male mice ... curcumin may be an effective therapeutic agent for LPS-induced depressive-like behavior, partially due to its anti-inflammatory aptitude"
• Efficacy of a novel water-soluble curcumin derivative versus sildenafil citrate in mediating erectile function - Int J Impot Res. 2014 Aug 7 - "The present study was conducted to assess the efficacy of a novel curcumin derivative (NCD) versus sildenafil citrate in erectile signaling. The study was conducted on 10 control male rats and 50 diabetic male rats divided into the following groups: diabetic, curcumin, NCD, sildenafil and NCD combined with sildenafil ... NCD or its combination with sildenafil showed significant efficacy and more prolonged duration of action. In conclusion, NCD could enhance erectile function with more efficacy and more prolonged duration of action"
• Investigation of the Efficacy of Adjunctive Therapy with Bioavailability-Boosted Curcuminoids in Major Depressive Disorder - Phytother Res. 2014 Aug 4 - "One hundred and eleven subjects were assigned to standard antidepressive therapy plus curcuminoids-piperine combination (1000-10 mg/day; n = 61) or standard antidepressive therapy alone (n = 50) for a period of 6 weeks ... Hospital Anxiety and Depression Scale (HADS) and Beck Depression Inventory II (BDI-II) ... There were significantly greater reductions in total HADS score and subscales of anxiety and depression in the curcuminoids versus control group (p < 0.001). Likewise, reductions in BDI-II total score and scores of somatic and cognitive subscales were found to be greater in the curcuminoids compared with control group" - See curcumin products at Amazon.com and piperine extract at Amazon.com.
• Molecular signalling of a novel curcumin derivative versus Tadalafil in erectile dysfunction - Andrologia. 2014 Jul 25 - "novel curcumin derivative (NCD) ... curcumin (CURC) ... In conclusion, a tendency was observed that CURC and NCD have high efficacy and more prolonged duration of action in enhancing erectile function"
• Effects of curcumin on learning and memory deficits, BDNF, and ERK protein expression in rats exposed to chronic unpredictable stress - Behav Brain Res. 2014 Jun 7 - "Recent studies have shown that curcumin exhibits antidepressant-like effects. The aim of the present study was to determine whether curcumin administration influences chronic unpredictable stress (CUS)-induced cognitive deficits and explores underlying mechanisms. Male Wistar rats were subjected to CUS protocol for a period of 5 weeks to induce depression. The depressive-like behavior was tested using sucrose preference test, open field test and Morris water maze test. Effects of curcumin on brain-derived neurotrophic factor (BDNF) and extracellular signal-regulated kinase (ERK) levels in the hippocampus were also examined. Chronic treatment with curcumin significantly reversed the CUS-induced behavioral and cognitive parameters (reduced sucrose preference and impaired learning and memory function) in stressed rats. Additionally, CUS reduced hippocampal BDNF and ERK levels, while curcumin effectively reversed these alterations"
• Curcumin Attenuates d-Galactosamine/Lipopolysaccharide-Induced Liver Injury and Mitochondrial Dysfunction in Mice - J Nutr. 2014 Jun 4 - "These results suggested that curcumin protects against d-GalN/LPS-induced liver damage by the enhancing antioxidant defense system, attenuating mitochondrial dysfunction and inhibiting apoptosis. This was especially true for curcumin pretreatment, which highlighted its promise as a preventive treatment for acute liver injury in clinical settings"
• Curcumin counteracts loss of force and atrophy of hindlimb-unloaded rat soleus by hampering nNOS untethering from sarcolemma - J Physiol. 2014 Apr 7 - "curcumin represents an effective and safe tool to upregulate Grp94 muscle levels and to maintain muscle function during unweighting"
• Curcumin suppresses proliferation of colon cancer cells by targeting CDK2 - Cancer Prev Res (Phila). 2014 Feb 18 - "Curcumin, the yellow pigment of turmeric found in Southeast Indian food, is one of the most popular phytochemicals for cancer prevention ... From these results, we identified CDK2 as a direct target of curcumin in colon cancer cells"
• Targeting Cancer Stem Cells by Curcumin and Clinical Applications - Cancer Lett. 2014 Jan 23 - "The anticancer effect of curcumin has been demonstrated in many cell and animal studies, and recent research has shown that curcumin can target cancer stem cells (CSCs). CSCs are proposed to be responsible for initiating and maintaining cancer, and contribute to recurrence and drug resistance ... the safety and tolerability of curcumin have been well-established by numerous clinical studies. Importantly, the low bioavailability of curcumin has been dramatically improved through the use of structural analogues or special formulations. More clinical trials are underway to investigate the efficacy of this promising agent in cancer chemoprevention and therapy"
• Comparative absorption of curcumin formulations - Nutr J. 2014 Jan 24;13(1):11 - "The relative absorption of a curcumin phytosome formulation (CP), a formulation with volatile oils of turmeric rhizome (CTR) and a formulation of curcumin with a combination of hydrophilic carrier, cellulosic derivatives and natural antioxidants (CHC) in comparison to a standardized curcumin mixture (CS) was investigated in a randomized, double-blind, crossover human study in healthy volunteers ... A formulation of curcumin with a combination of hydrophilic carrier, cellulosic derivatives and natural antioxidants significantly increases curcuminoid appearance in the blood in comparison to unformulated standard curcumin CS, CTR and CP"
• Curcumin: A Double Hit on Malignant Mesothelioma - Cancer Prev Res (Phila). 2014 Jan 15 - "Our data indicates that curcumin has a double effect on MM cells through induction of pyroptosis while subsequently protecting against inflammation"
• Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice - Atherosclerosis. 2014 Jan;232(1):40-51 - "Consuming curcumin may benefit health by modulating lipid metabolism and suppressing atherogenesis. Fatty acid binding proteins (FABP-4/aP2) and CD36 expression are key factors in lipid accumulation in macrophages and foam cell formation in atherogenesis ... Curcumin through a series of complex mechanisms, alleviated the adverse effects of high fat diet on weight gain, fatty liver development, dyslipidemia, expression of inflammatory cytokines and atherosclerosis in Ldlr(-/-) mouse model of human atherosclerosis. One of the mechanisms by which low dose curcumin modulates atherogenesis is through suppression of aP2 and CD36 expression in macrophages, which are the key players in atherogenesis. Overall, these effects of curcumin are dose-dependent; specifically, a medium dose of curcumin in HF diet appears to be more effective than a higher dose of curcumin"
• Coadministration of Erlotinib and Curcumin Augmentatively Reduces Cell Viability in Lung Cancer Cells - Phytother Res. 2013 Aug 13 - "Resistance to erlotinib in lung cancer cases includes T790M mutant epidermal growth factor receptor and c-Met gene amplification, but other unknown mechanisms account for about 30% of the resistance. Activation of the nuclear factor kappa B (NFkappaB)-related pathways in association with the reduction in ikappaB level may be one of such potential mechanisms. It is known that curcumin inhibits the inducible activation of NFkappaB at least in part by sustaining ikappaB expression level ... We found that erlotinib and curcumin augmentatively reduced cell viability ... Furthermore, coadministration of erlotinib and/or curcumin augmentatively attenuated the growth of PC9 tumors in mice"
• Induction of Human Breast Cell Carcinogenesis by Triclocarban and Intervention by Curcumin - Biochem Biophys Res Commun. 2013 Aug 10 - "More than 85% of breast cancers are sporadic and attributable to long-term exposure to environmental carcinogens and co-carcinogens. To identify co-carcinogens with abilities to induce cellular pre-malignancy, we studied the activity of triclocarban (TCC), an antimicrobial agent commonly used in household and personal care products. Here, we demonstrated, for the first time, that chronic exposure to TCC at physiologically-achievable nanomolar concentrations resulted in progressive carcinogenesis of human breast cells from non-cancerous to pre-malignant ... Using TCC-induced transient and constitutive endpoints as targets will likely help identify non-cytotoxic preventive agents, such as curcumin, effective in suppressing TCC-induced cellular pre-malignancy" - See curcumin products at Amazon.com.
• Are Curcuminoids Effective C-Reactive Protein-Lowering Agents in Clinical Practice? Evidence from a Meta-Analysis - Phytother Res. 2013 Aug 7 - "Inflammation plays a pivotal role in the pathogenesis of atherosclerosis and cardiovascular disease (CVD). In this context, C-reactive protein (CRP) has been identified as a strong predictor and independent risk factor of CVD. Curcuminoids are multifunctional natural product with promising cardioprotective and anti-inflammatory properties ... PubMed/MEDLINE and SCOPUS databases were searched ... Compared with placebo, supplementation with curcuminoids was associated with a significant reduction in circulating CRP levels (weighed mean difference: -6.44 mg/L; 95% CI: -10.77 - -2.11; p = 0.004). This significant effect was maintained in subgroups of trials that used bioavailability-improved preparations of curcuminoids and had supplementation duration of ≥4 weeks, but not in the subgroups without these characteristics ... effect appears to depend on the bioavailability of curcuminoids preparations and also duration of supplementation" - See curcumin products at Amazon.com.
• Curcumin protects neuronal-like cells against acrolein by restoring Akt and redox signaling pathways - Mol Nutr Food Res. 2013 Jul 31 - "Our results provided evidence that curcumin was able to protect SK-N-SH cells against acrolein toxicity. This protection is mediated through the antioxidant, the redox, and the survival regulated pathways by curcumin. Moreover, our results demonstrated that Nps-Cur had higher capacity than curcumin to protect SK-N-SH cells against acrolein"
• Therapeutic Potential of Turmeric in Alzheimer's Disease: Curcumin or Curcuminoids? - Phytother Res. 2013 Jul 19 - "Alzheimer's disease (AD) is the most common form of dementia. There is limited choice in modern therapeutics, and drugs available have limited success with multiple side effects in addition to high cost. Hence, newer and alternate treatment options are being explored for effective and safer therapeutic targets to address AD. Turmeric possesses multiple medicinal uses including treatment for AD. Curcuminoids, a mixture of curcumin, demethoxycurcumin, and bisdemethoxycurcumin, are vital constituents of turmeric. It is generally believed that curcumin is the most important constituent of the curcuminoid mixture that contributes to the pharmacological profile of parent curcuminoid mixture or turmeric. A careful literature study reveals that the other two constituents of the curcuminoid mixture also contribute significantly to the effectiveness of curcuminoids in AD. Therefore, it is emphasized in this review that each component of the curcuminoid mixture plays a distinct role in making curcuminoid mixture useful in AD, and hence, the curcuminoid mixture represents turmeric in its medicinal value better than curcumin alone"
• Curcumin I Mediates Neuroprotective Effect Through Attenuation of Quinoprotein Formation, p-p38 MAPK Expression, and Caspase-3 Activation in 6-Hydroxydopamine Treated SH-SY5Y Cells - Phytother Res. 2013 Jul 16 - "6-Hydroxydopamine (6-OHDA) selectively enters dopaminergic neurons and undergoes auto-oxidation resulting in the generation of reactive oxygen species and dopamine quinones, subsequently leading to apoptosis. This mechanism mimics the pathogenesis of Parkinson's disease and has been used to induce experimental Parkinsonism in both in vitro and in vivo systems ... curcumin I (diferuloylmethane) purified from Curcuma longa ... Our results clearly demonstrated that curcumin I protects neurons against oxidative damage, as shown by attenuation of p-p38 expression, caspase-3-activation, and toxic quinoprotein formation, together with the restoration of p-TH levels. This study provides evidence for the therapeutic potential of curcumin I in the chemoprevention of oxidative stress-related neurodegeneration"
• Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial - Phytother Res. 2013 Jul 6 - "60 patients diagnosed with MDD were randomized in a 1:1:1 ratio for six weeks observer-masked treatment with fluoxetine (20 mg) and curcumin (1000 mg) individually or their combination ... curcumin was well tolerated by all the patients. The proportion of responders as measured by the HAM-D17 scale was higher in the combination group (77.8%) than in the fluoxetine (64.7%) and the curcumin (62.5%) groups; however, these data were not statistically significant (P = 0.58). Interestingly, the mean change in HAM-D17 score at the end of six weeks was comparable in all three groups (P = 0.77). This study provides first clinical evidence that curcumin may be used as an effective and safe modality for treatment in patients with MDD without concurrent suicidal ideation or other psychotic disorders"
• Curcumin: An Orally Bioavailable Blocker of TNF and Other Pro-inflammatory Biomarkers - Br J Pharmacol. 2013 Feb 20 - "TNF blockers are now being used for the treatment of osteoarthritis, inflammatory bowel disease, psoriasis, and ankylosis at a total cumulative market value of more than $20 billion/year. Besides being expensive ($15,000-20,000/person/year), these drugs must be injected and have enough adverse effects to be given a black label warning by the FDA. In the current report, we describe an alternative, curcumin (diferuloylmethane), a component of turmeric (Curcuma longa) that is very inexpensive, orally bioavailable, and highly safe in humans, yet can block TNF-α action and production in in vitro models, in animal models, and in humans. In addition, we provide evidence for curcumin's activities against all of the diseases for which TNF blockers are being used. Mechanisms by which curcumin inhibits the production and the cell signaling pathways activated by this cytokine are also discussed. With health care costs and safety being major issues today, this golden spice may help provide the solution"
• Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway - Mol Nutr Food Res. 2012 Nov 23 - "These findings demonstrate that, by modulating Nrf2-Keap1 pathway, the curcumin effectively attenuates oxidative stress, inflammation, and renal fibrosis, which suggest that curcumin hold promising potential for safe treatment of chronic kidney disease"
• Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people - Nutr J. 2012 Sep 26;11(1):79 - "Curcumin extracts of turmeric are proposed to produce health benefits. To date, human intervention studies have focused mainly on people with existing health problems given high doses of poorly absorbed curcumin. The purpose of the current study was to check whether in healthy people, a low dose of a lipidated curcumin extract could alter wellness-related measures ... The present study was conducted in healthy middle aged people (40--60 years old) with a low dose of curcumin (80 mg/day) in a lipidated form expected to have good absorption ... Curcumin, but not placebo, produced the following statistically significant changes: lowering of plasma triglyceride values, lowering of salivary amylase levels, raising of salivary radical scavenging capacities, raising of plasma catalase activities, lowering of plasma beta amyloid protein concentrations, lowering of plasma sICAM readings, increased plasma myeloperoxidase without increased c-reactive protein levels, increased plasma nitric oxide, and decreased plasma alanine amino transferase activities" - See iHerb search of lipidated curcumin.
• Curcumin promotes cardiac repair and ameliorates cardiac dysfunction following myocardial infarction - Br J Pharmacol. 2012 Jul 24 - "Curcumin, the natural yellow pigment extracted from the rhizomes of the plant curcuma longa, has been demonstrated to exhibit a variety of potent beneficial effects such as anti-oxidant, anti-inflammation and anti-fibrosis ... Sprague-Dawley rats ... The dietary curcumin is effective in inhibiting maladaptive cardiac repair and preserving cardiac function after ischemia and reperfusion. These results further support that there is a potential use of curcumin in treatment of patient after a heart attack"
• Curcumin Extract for Prevention of Type 2 Diabetes - Diabetes Care. 2012 Jul 6 - "After 9 months of treatment, 16.4% of subjects in the placebo group were diagnosed with T2DM, whereas none were diagnosed with T2DM in the curcumin-treated group. In addition, the curcumin-treated group showed a better overall function of β-cells, with higher HOMA-β (61.58 vs. 48.72; P < 0.01) and lower C-peptide (1.7 vs. 2.17; P < 0.05). The curcumin-treated group showed a lower level of HOMA-IR (3.22 vs. 4.04; P < 0.001) and higher adiponectin (22.46 vs. 18.45; P < 0.05) when compared with the placebo group"
• Curry spice component may help slow prostate tumor growth - Science Daily, 2/10/12 - "androgen deprivation therapy (ADT) ... curcumin suppresses two known nuclear receptor activators, p300 and CPB (or CREB1-binding protein), which have been shown to work against ADT ... These data demonstrate for the first time that curcumin not only hampers the transition of ADT-sensitive disease to castration-resistance, but is also effective in blocking the growth of established castrate-resistant prostate tumors"
• Curcumin Attenuates TNF-α-induced Expression of Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1 and Proinflammatory Cytokines in Human Endometriotic Stromal Cells - Phytother Res. 2011 Dec 20 - "These findings suggest that curcumin may have potential therapeutic uses in the prevention and treatment of endometriosis"
• Curcumin is a potent modulator of microglial gene expression and migration - J Neuroinflammation. 2011 Sep 29;8(1):125 - "our results suggest that curcumin is a potent modulator of the microglial transcriptome. Curcumin attenuates microglial migration and triggers a phenotype with anti-inflammatory and neuroprotective properties. Thus, curcumin could be a nutraceutical compound to develop immuno-modulatory and neuroprotective therapies for the treatment of various neurodegenerative disorders"
• Innovative preparation of curcumin for improved oral bioavailability - Biol Pharm Bull. 2011;34(5):660-5
• Curcumin-soy formulation may boost absorption 60-fold: Indena study - Nutra USA, 4/6/11 - "Curcumin has been a sort of ‘forbidden fruit’ for biomedical research, since its poor oral bioavailability has substantially hampered clinical development, despite the very promising indications of the preclinical research ... The volunteers received five (low-dose - 209 mg total curcuminoids) or nine (high-dose - 376 mg total curcuminoids) hard-shell capsules of either the soybean-based phospholipid-curcumin formulation (Meriva) or five capsules of a non-formulated curcuminoid mixture containing 1799 mg of curcuminoids ... Total curcuminoid absorption was about 29-fold higher for Meriva than for its corresponding unformulated curcuminoid mixture, but only phase-2 metabolites could be detected, and plasma concentrations were still significantly lower than those required for the inhibition of most anti-inflammatory targets of curcumin ... the major plasma curcuminoid after administration of Meriva was not curcumin, but demethoxycurcumin, a more potent analogue in many in vitro anti-inflammatory assays" - [Abstract]
• Curcumin attenuates lipopolysaccharide-induced renal inflammation - Biol Pharm Bull. 2011;34(2):226-32 - "Renal inflammation is the main pathological change in many acute and chronic kidney diseases. Curcumin, a yellow pigment present in the rhizome of turmeric (Curcuma longa L. Zingiberaceae), was found to be a potential anti-inflammatory agent ... The results demonstrated that curcumin could inhibit LPS-induced renal MCP-1 mRNA expression. Curcumin also significantly inhibited the expression of MCP-1 and IL-2 mRNA in HK-2 cells, and partially inhibited the secretion of MCP-1 and IL-8. Furthermore, curcumin was found to inhibit the DNA-binding activity of NF-κB. The present study demonstrated that curcumin has a protective effect on LPS-induced experimental renal inflammation, and this effect might be attributed to its inhibitory effects on MCP-1 mRNA expression and DNA-binding activity of NF-κB. Hence, curcumin might be potentially useful in some kidney diseases by preventing renal inflammation"
• Curcuminoids Suppress the Growth and Induce Apoptosis through Caspase-3-Dependent Pathways in Glioblastoma Multiforme (GBM) 8401 Cells - J Agric Food Chem. 2010 Sep 7 - "The results observed with proliferation inhibition (y = 94.694e(-0.025x), R(2) = 0.9901, and n = 6) and apoptosis (y = 0.9789e(-0.0102x), R(2) = 0.99854, and n = 3) depend upon the amount of curcuminoid treatment in the cancer cells"
• Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis - Int J Cancer. 2010 Sep 7 - "Cholangiocarcinoma (CCA) is a highly metastatic tumor linked to liver fluke infection and consumption of nitrosamine-contaminated foods, and is a major health problem especially in South-Eastern Asia ... Our results suggest that curcumin exhibits an anticarcinogenic potential via suppression of various events involved in multiple steps of carcinogenesis, which is accounted for by its ability to suppress proinflammatory pathways"
• Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway - Biochem Biophys Res Commun. 2010 Jul 10 - "Curcumin extracted from the rhizomes of C. longa L has been shown to have inhibitory effects on cancers through its anti-proliferative and pro-apoptotic activities. Emerging evidence demonstrates that curcumin can overcome drug resistance to classical chemotherapies. Thus, the mechanisms underlying the antitumor activities of curcumin require further study. In our study, we first demonstrated that curcumin had anti-cancer effects on A549/DDP multidrug-resistant human lung adenocarcinoma cells. Further studies showed that curcumin altered miRNA expression; in particular, significantly downregulated the expression of miR-186 * in A549/DDP. In addition, transfection of cells with a miR-186 * inhibitor promoted A549/DDP apoptosis, and overexpression of miR-186 * significantly inhibited curcumin-induced apoptosis in A549/DDP cells. These observations suggest that miR-186 * may serve as a potential gene therapy target for refractory lung cancer that is sensitive to curcumin"
• Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression - Lipids Health Dis. 2010 Apr 19;9(1):40 - "Curcumin inhibits cholesterol uptake through suppression of NPC1L1 expression in the intestinal cells"
• Curcumin improves insulin resistance in skeletal muscle of rats - Nutr Metab Cardiovasc Dis. 2010 Mar 12 - "Curcumin improves muscular insulin resistance by increasing oxidation of fatty acid and glucose, which is, at least in part, mediated through LKB1-AMPK pathway"
• Synergistic role of curcumin with current therapeutics in colorectal cancer: minireview - Nutr Cancer. 2009 Nov;61(6):842-6 - "Despite the use of surgical resection and aggressive chemotherapy, nearly 50% of patients with colorectal carcinoma develop recurrent disease, highlighting the need for improved therapies. Curcumin (diferuloylmethane), the major active ingredient of turmeric (curcuma longa) with no discernable toxicity, has been shown to inhibit the growth of transformed cells and colon carcinogenesis at the initiation, promotion, and progression stages in carcinogen-induced rodent models. In a Phase I clinical trial, curcumin has been found to be extremely well tolerated and effective ... Existing data suggest that curcumin in combination with chemotherapy is a superior strategy for treatment of gastrointestinal cancer"
• Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease - Br J Nutr. 2009 Nov 2:1-9 - "We conclude that curcumin, a naturally occurring food substance with no known human toxicity, holds promise as a novel therapy in IBD"
• Curcumin synergizes with resveratrol to inhibit colon cancer - Nutr Cancer. 2009;61(4):544-53 - "the combination of curcumin and resveratrol was found to be more effective in inhibiting growth of p53-positive (wt) and p53-negative colon cancer HCT-116 cells in vitro and in vivo in SCID xenografts of colon cancer HCT-116 (wt) cells than either agent alone. Analysis by Calcusyn software showed synergism between curcumin and resveratrol. The inhibition of tumors in response to curcumin and/or resveratrol was associated with the reduction in proliferation and stimulation of apoptosis accompanied by attenuation of NF-kappaB activity. In vitro studies have further demonstrated that the combinatorial treatment caused a greater inhibition of constitutive activation of EGFR and its family members as well as IGF-1R. Our current data suggest that the combination of curcumin and resveratrol could be an effective preventive/therapeutic strategy for colon cancer"
• 1α,25-dihydroxyvitamin D_{3} Interacts with Curcuminoids to Stimulate Amyloid-β Clearance by Macrophages of Alzheimer's Disease Patient - J Alzheimers Dis. 2009 May 11 - "1,25D3 strongly stimulated Abeta phagocytosis and clearance while protecting against apoptosis. Certain synthetic curcuminoids in combination with 1,25D3 had additive effects on phagocytosis in Type I but not Type II macrophages. In addition, we investigated the mechanisms of 1,25D3 and curcuminoids in macrophages. The 1,25D3 genomic antagonist analog MK inhibited 1,25D3 but not curcuminoid effects, suggesting that 1,25D3 acts through the genomic pathway. In silico, 1,25D3 showed preferential binding to the genomic pocket of the vitamin D receptor, whereas bisdemethoxycurcumin showed preference for the non-genomic pocket. 1,25D3 is a promising hormone for AD immunoprophylaxis because in Type I macrophages combined treatment with 1,25D3 and curcuminoids has additive effects, and in Type II macrophages 1,25D3 treatment is effective alone. Human macrophages are a new paradigm for testing immune therapies for AD" - See vitamin D at Amazon.comand curcumin products at Amazon.com.
• Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model - Int J Cancer. 2009 May 26 - "Because of the poor prognosis and the development of resistance against chemotherapeutic drugs, the current treatment for advanced metastatic colorectal cancer (CRC) is ineffective. Whether curcumin (a component of turmeric) can potentiate the effect of capecitabine against growth and metastasis of CRC was investigated ... In nude mice, the combination of curcumin and capecitabine was found to be more effective than either agent alone in reducing tumor volume (p = 0.001 vs. control; p = 0.031 vs. capecitabine alone), Ki-67 proliferation index (p = 0.001 vs. control) and microvessel density marker CD31. The combination treatment was also highly effective in suppressing ascites and distant metastasis to the liver, intestines, lungs, rectum and spleen. This effect was accompanied by suppressed expression of activated NF-kappaB and NF-kappaB-regulated gene products (cyclin D1,c-myc, bcl-2, bcl-xL, cIAP-1, COX-2, ICAM-1, MMP-9, CXCR4 and VEGF). Overall, our results suggest that curcumin sensitizes CRC to the antitumor and antimetastatic effects of capecitabine by suppressing NF-kappaB cell signaling pathway"
• Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells - Br J Pharmacol. 2009 Jul 7 - "This curcumin, a constituent of turmeric, may be useful in preventing hypercholesterolemia-associated hepatic fibrogenesis" - See curcumin products at Amazon.com.
• Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice - J Nutr. 2009 May;139(5):919-25 - "Supplementing the high-fat diet of mice with curcumin did not affect food intake but reduced body weight gain, adiposity, and microvessel density in adipose tissue, which coincided with reduced expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2. Curcumin increased 5'AMP-activated protein kinase phosphorylation, reduced glycerol-3-phosphate acyl transferase-1, and increased carnitine palmitoyltransferase-1 expression, which led to increased oxidation and decreased fatty acid esterification ... Our findings suggest that dietary curcumin may have a potential benefit in preventing obesity"
• Curcumin and cancer: An "old-age" disease with an "age-old" solution - Cancer Lett. 2008 May 5 - "The activity of curcumin reported against leukemia and lymphoma, gastrointestinal cancers, genitourinary cancers, breast cancer, ovarian cancer, head and neck squamous cell carcinoma, lung cancer, melanoma, neurological cancers, and sarcoma reflects its ability to affect multiple targets. Thus an "old-age" disease such as cancer requires an "age-old" treatment"
• Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells - Int J Cancer. 2008 Apr 3 - "Interestingly, curcumin caused cell cycle arrest in G2-M and a significant reduction (80-97%) in H-RS cell viability. Furthermore, curcumin triggered cell death by apoptosis, as evidenced by the activation of caspase-3 and caspase-9, changes in nuclear morphology and phosphatidylserine translocation. The above findings provide a mechanistic rationale for the potential use of curcumin as a therapeutic agent for patients with HL"
• Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus - J Biol Chem. 2008 Mar 24 - "Administration of curcumin to adult mice resulted in a significant increase in the number of newly-generated cells in the dentate gyrus of hippocampus, indicating that curcumin enhances adult hippocampal neurogenesis"
• Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model - Cancer Lett. 2008 Mar 12 - "Exposure of human bladder cancer cells to curcumin resulted in the induction of apoptotic cell death and caused cells to arrest in the G2/M phase. The anti-apoptotic Bcl-2 and Survivin protein was downregulated by the curcumin treatment together with enhancement of the Bax and p53 expression. The inhibitory activities of curcumin were stronger than those of cisplatin and could not be prevented by catalase pretreatment in T24 cells. Clonal assay indicated large-dose and short-term curcumin was lethal to bladder cancer cells. Moreover, the in vivo study revealed curcumin did induce apoptosis in situ, inhibit and slow the development of bladder cancer. These observations suggest that curcumin could prove an effective chemopreventive and chemotherapy agent for bladder cancer"
• The combination of epigallocatechin gallate and curcumin suppresses ERalpha-breast cancer cell growth in vitro and in vivo - Int J Cancer. 2007 Dec 20 - "Tumor volume in the EGCG + curcumin treated mice decreased 49% compared to vehicle control mice (p < 0.05), which correlated with a 78 +/- 6% decrease in levels of VEGFR-1 protein expression in the tumors. Curcumin treatment significantly decreased tumor protein levels of EGFR and Akt, however the expression of these proteins was not further decreased following combination treatment. Therefore, these results demonstrate that the combination of EGCG and curcumin is efficacious in both in vitro and in vivo models of ERalpha- breast cancer and that regulation of VEGFR-1 may play a key role in this effect"
• Effect of Curcumin on Inflammation and Oxidative Stress in Cisplatin-Induced Experimental Nephrotoxicity - J Agric Food Chem. 2007 Nov 15 - "curcumin has a protective effect on cisplatin-induced experimental nephrotoxicity, and this effect is attributed to its direct anti-inflammatory and strong antioxidant profile. Hence, curcumin has a strong potential to be used as a therapeutic adjuvant in cisplatin nephrotoxicity" - See curcumin products at Amazon.com.
• Curcumin for chemoprevention of colon cancer - Cancer Lett. 2007 Apr 18 - "Overwhelming in vitro evidence and completed clinical trials suggests that curcumin may prove to be useful for the chemoprevention of colon cancer in humans"