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Sepsis

Alternative News:

• Protective effect of Astragalus membranaceus and Astragaloside IV in sepsis-induced acute kidney injury - Aging (Albany NY) 2022 Jul 20 - "Acute kidney injury (AKI) is the most common target organ damage in sepsis. Sepsis-associated AKI (SA-AKI) may be characterized by damage to the renal tubular epithelium ... Astragalus membranaceus and AS-IV protect against sepsis-induced kidney tubular injury by activating the PI3K/AKT pathway" - See astragalus at Amazon.com.
• Curcumin Improved Intestinal Epithelial Barrier Integrity by Up-Regulating ZO-1/Occludin/Claudin-1 in Septic Rats - Evid Based Complement Alternat Med 2022 Jun 7 - "To investigate the protective effect and mechanism of curcumin on intestinal barrier function in rats with enterogenic sepsis ... Curcumin can reduce inflammatory response and upregulate the expression of intestinal tight junction proteins ZO-1, occludin, and claudin-1 in rats with enterogenic sepsis, and protect intestinal barrier function" - See curcumin at Amazon.com.
• Panax notoginseng Alleviates Sepsis-Induced Acute Kidney Injury by Reducing Inflammation in Rats - Evid Based Complement Alternat Med 2022 May 21 - "Sepsis is defined as a host inflammatory response to infection that can result in end-organ dysfunction. One of the most common consequences of sepsis is acute kidney injury (AKI). Panax notoginseng powder (PNP) has been previously reported to protect against overactive inflammation process ... PNP attenuated kidney inflammation to protect against CLP-induced septic AKI in rats via inhibiting the NF-κB signaling pathway" - See Panax ginseng at Amazon.com.
• Nano-curcumin supplementation in critically ill patients with sepsis: a randomized clinical trial investigating the inflammatory biomarkers, oxidative stress indices, endothelial function, clinical outcomes and nutritional status - Food Funct 2022 May 27 - "Sepsis is a severe reaction and excessive immune response to infection, which can lead to organ dysfunction, and death. This study aimed to investigate the protective effect of nano-curcumin (NC) on inflammatory biomarkers, endothelial function, oxidative stress indices, biochemical factors, nutritional status, and clinical outcomes in patients with sepsis ... Supplementation with NC may be a promising treatment strategy for critically ill patients with sepsis" - See curcumin at Amazon.com.
• Therapeutic potential of mega-dose vitamin C to reverse organ dysfunction in sepsis and COVID-19 - Br J Pharmacol 2021 Jun 1 - "Sepsis induced by bacteria or viruses can result in multi-organ dysfunction, which is a major cause of death in intensive care units. Current treatments are only supportive and there are no treatments that reverse the pathophysiological effects of sepsis. Vitamin C has antioxidant, anti-inflammatory, anticoagulant and immune modulatory actions, so is a rational treatment for sepsis ... Mega-dose intravenous sodium ascorbate (150 g/40 kg over 7-h) dramatically improved the clinical state and cardiovascular, pulmonary, hepatic and renal function and decreased body temperature, in a clinically relevant ovine model of gram-negative bacteria-induced sepsis. In a critically ill COVID-19 patient, intravenous sodium ascorbate (60 g) restored arterial pressure, improved renal function and increased arterial blood oxygen levels. These findings suggest that megadose vitamin C should be trialled as a treatment for sepsis and COVID-19" - See American Health Ester-c With Citrus Bioflavonoids 500 Mg, 240 Count.
• Doctors Say Their COVID-19 Protocol Saves Lives. Others Want Proof - Medscape, 7/16/20 - "MATH+ stands for methylprednisolone, ascorbic acid, thiamine, and heparin. The "+" holds a place for additional therapies like vitamin D, zinc, and melatonin. The protocol originated as a variation of the "HAT therapy," a combination of hydrocortisone, ascorbic acid, and thiamine, which critical care specialist Paul Marik, MD, created for treating critically ill patients with sepsis." - See Vitamin C products at Amazon.com and vitamin C at iHerb.com and Jarrow Zinc Balance at Amazon.com and iHerb and melatonin at Amazon.com and iHerb and vitamin D at Amazon.com and vitamin D at iHerb.
• Vitamin C therapy linked to better survival rates after sepsis - Science Daily, 10/1/19 - "intravenous vitamin C therapy reduced mortality in septic patients from 46% in the placebo group to almost 30% in the vitamin C group at day 28 ... This therapy could potentially transform the way we care for sepsis patients. We may have found a lifesaving therapy" - See American Health Ester-c With Citrus Bioflavonoids 500 Mg, 240 Count.
• Vitamin Cocktail for Sepsis Getting Wider Test - WebMD, 5/21/18 - "Paul Marik, MD, reported in 2017 that he gave a mix of vitamin C, vitamin B1, and a steroid to nearly four dozen patients who had sepsis in his Norfolk intensive care unit. In the 7 months before he started using the treatment, 19 of 47 sepsis patients died. Of the 47 who got the treatment, all but four survived"
• Vitamin C may offer potential life-saving treatment for sepsis - Science Daily, 11/17/10 - "vitamin C can not only prevent the onset of sepsis, but can reverse the disease"
• Vitamin C may prevent and help sepsis - Nutra USA, 11/18/10
• Green Tea Proves A Powerful Medicine Against Severe Sepsis In the Lab - Science Daily, 11/8/07 - "Survival jumped from 53 percent in those who didn't receive the green tea substance to 82 percent in those who did. "Clinically, even if we could save five percent of patients, that would be huge," ... In this study, we saved 25 percent more animals with the green tea" - See green tea extract at Amazon.com.

Other News:

• The Impact of Statin Use prior to intensive Care Unit (icu) Admission on critically Ill Patients with sepsis -Pharmacotherapy 2021 Jan 22 - "length of stay (LOS) ... Among patients with sepsis admitted to the medical ICU, pre-ICU statin use is causally associated with a decrease in 30-day ICU mortality, ICU LOS, and 30-day in-hospital mortality compared to non-use. This study adds to the totality of evidence on the pleiotropic effect of statin use in patients with sepsis"
• Sepsis and septic shock more common than heart attacks or pulmonary blood clots after general surgery, study finds - Science Daily, 7/19/10
• Two treatment strategies for severe sepsis show similar survival rates - Science Daily, 2/23/10
• Septic shock: Nitric oxide beneficial after all - Science Daily, 12/15/09
• New therapy may be effective against bacterial infections and sepsis - Science Daily, 11/29/09
• Inappropriate Sepsis Therapy Leads To Fivefold Reduction In Survival - Science Daily, 11/5/09
• Fast Magnetic Fix For Sepsis? Micromagnetic-microfluidic Device Could Quickly Pull Pathogens From The Bloodstream - Science Daily, 3/25/09
• Sepsis Guideline Compliance Improves, Rate Of Death Declines After Educational Effort - Science Daily, 5/20/08
• Customized Treatments For Sepsis Lower Treatment Time And Reduce Length Of ICU Stays - Science Daily, 2/29/08
• Boys With Blood Infection Suffer More Severely Than Girls - Science Daily, 10/17/07
• Protocol For Treatment Of Sepsis Can Reduce Hospital Deaths - Science Daily, 5/16/07
• Xigris May Increase Mortality in Lower-Risk Sepsis Patients - Medscape, 3/19/05
• Severe Sepsis Causes Almost 10% Of Cancer Deaths - Science Daily, 7/5/04
• Baseline Cortisol Predicts Benefit of Steroid Treatment in Sepsis Patients - Doctor's Guide, 3/1/04
• Timing of Activated Protein C Initiation Influences Sepsis Survival - Doctor's Guide, 2/27/04
• Early Initiation of Drotregocin Alfa Linked to Improved Sepsis Survival - Doctor's Guide, 2/27/04
• Meta-Analysis Confirms Benefit of Low-Dose Steroid Course for Treatment of Sepsis - Doctor's Guide, 2/27/04
• Low-Dose Steroids Are Beneficial in Sepsis - Medscape, 2/26/04
• International Critical Care Doctors Release First-Ever Guidelines For Sepsis - Doctor's Guide, 2/25/04
• Study Suggests Statins May Reduce Sepsis Risk - Doctor's Guide, 2/24/04
• Doctors aim to reduce deaths from common blood infection - USA Today, 2/14/04
• Drotrecogin Alfa (Activated) Achieves Optimal Results in Sepsis Patients Co-Diagnosed With Community-Acquired Pneumonia - Doctor's Guide, 10/30/03
• Severe Sepsis and Septic Shock: A Paradigm Shift for Emergency Medicine - Physician's Weekly, 9/15/03
• Sepsis Drug Benefits Older Patients - Physician's Weekly, 9/8/03
• Reliance On Culture-proven Sepsis Figures Underestimates Incidence Of Early-onset Group B Streptococcal Sepsis In Neonates - Doctor's Guide, 6/9/03
• Increased Use of Intrapartum Antibiotic Fails to Decrease Incidence of Early-Onset Sepsis - Doctor's Guide, 5/6/03
• Sepsis Cases on the Rise in the U.S. - WebMD, 4/16/03