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Rhodiola Rosea

Specific Recommendations:

• Rhodiola rosea at Amazon.com and iHerb

News & Research:

• Herbal Extract Boosts Fruit Fly Lifespan by Nearly 25 Percent - Science Daily, 6/18/13 - "Rhodiola works in a manner completely unrelated to dietary restriction and affects different molecular pathways ... Rhodiola can act even in individuals who are already long-lived and healthy. This is quite unlike resveratrol, which appears to only act in overfed or unhealthy individuals ... Not only did Rhodiola improve lifespan an average of 24 percent in both sexes and multiple strains of flies, but it also delayed the loss of physical performance in flies as they aged and even extended the lives of old flies ... Rhodiola has already shown possible health benefits in humans, such as decreasing fatigue, anxiety and depression; boosting mood, memory and stamina; and preventing altitude sickness" - See Rhodiola rosea at Amazon.com.
• Rhodiola rosea: Nature’s antidepressant - Fox News, 9/10/12 - "Over 300 human studies on Rhodiola rosea show that the plant has anti-stress, anti-anxiety, and anti-depressant properties, and that taking the extract of the root produces no significant negative effects ... Overall, Rhodiola rosea demonstrates greater effectiveness and safety than pharmaceutical drugs for anxiety, depression and fatigue. So why don’t more doctors recommend Rhodiola to their patients? They don’t know about it. For many medical doctors, the herbal world is still a dark green jungle of uncertainty"
• Rhodiola for What Ails You? - Dr. Weil, 5/15/08 - "A 2002 review in Herbalgram, the Journal of the American Botanical Council, reported that over the years, numerous studies of rhodiola in humans and animals have shown that it helps prevent fatigue, stress and the damaging effects of oxygen deprivation. Evidence also suggests that it has an antioxidant effect, enhances immune system function and can increase sexual energy ... A study published in 2007 in the Nordic Journal of Psychiatry showed that patients with mild-to-moderate depression who took a rhodiola extract reported fewer symptoms than those who took a placebo. And a study by researchers at the University of California at Irvine found that fruit flies that ate a diet supplemented with rhodiola lived an average of 10 percent longer than flies that didn't eat this herb"
• Herbal Extract Found To Increase Lifespan - Science Daily, 12/5/07 - "Flies that ate a diet rich with Rhodiola rosea, an herbal supplement long used for its purported stress-relief effects, lived on an average of 10 percent longer than fly groups that didn’t eat the herb ... Although this study does not present clinical evidence that Rhodiola can extend human life, the finding that it does extend the lifespan of a model organism, combined with its known health benefits in humans, make this herb a promising candidate for further anti-aging research ... Rhodiola rosea ... has been used by Scandinavians and Russians for centuries for its anti-stress qualities ... patients taking a Rhodiola extract called SHR-5 reported fewer symptoms of depression than did those who took a placebo"
• Warming to a Cold War Herb - Science News, 9/22/07 - "Government scientists had noted that rhodiola boosted the body's response to stress ... Almost immediately, my mind seemed clearer ... After a few days, I noticed I recovered from exercise more quickly"
• Rhodiola - The Cellular Energy-Boosting Herb - Life Extension Magazine, 2/06 - "With its ability to increase mental energy and physical endurance, rhodiola has tremendous potential to counteract many negative effects of the aging process. Studies show that rhodiola can favorably support the body’s stress reaction, both mentally and physically. In research trials, rhodiola has been shown to boost brain function and have anti-cancer effects"
• Cortisol, Stress, and Health - Life Extension Magazine, 12/05 - "Supplements to reduce high cortisol levels secondary to stress ... Vitamin C: 1000-3000 mg/day ... Fish oil (omega-3 fatty acids):1-4 gm/day ... Phosphatidylserine: 300-800 mg/day ... Rhodiola rosea: 100-200 mg/day, standardized extract ... Ginseng: 100-300 mg/day, standardized extract ... Ginkgo biloba: 100-200 mg/day, standardized extract ... DHEA: 25-50 mg/day (any hormone supplementation should be monitored by your physician)"

Abstract:

• Anti-Photoaging Effect of Rhodiola rosea Fermented by Lactobacillus plantarum on UVA-Damaged Fibroblasts - Nutrients 2022 Jun 1 - "UVA can cause oxidative stress and photoaging of cells. We established a UVA-induced oxidative stress model of human fibroblasts and focused on the antioxidant and anti-photoaging ability of Lactobacillus plantarum fermented Rhodiola rosea. Compared with the unfermented Rhodiola rosea, Lactobacillus plantarum fermented Rhodiola rosea has better DPPH free radical and hydroxyl free radical scavenging ability, significantly reduces the content of reactive oxygen species (ROS), and improves the antioxidant level. Further studies have shown that the Lactobacillus plantarum fermented Rhodiola rosea can activate the Nrf2/Keap1 signaling pathway and up-regulate heme oxygenase-1 (HO-1), NAD(P)H quinone dehydrogenase 1 (NQO1), catalase (CAT) and glutathione Peptide peroxidase (GSH-Px), and protect fibroblasts from oxidative stress caused by UVA. On the other hand, Lactobacillus plantarum fermented Rhodiola rosea significantly reduces the activity of metalloproteinases in the cell, thereby increasing the collagen and elastin in the cell, alleviating the photoaging caused by UVA. Finally, we concluded that the antioxidant capacity and anti-photoaging ability of Lactobacillus plantarum fermented Rhodiola rosea are better than that of unfermented Rhodiola rosea" - See fermented Rhodiola rosea (It doesn't show any fermented. Google shows several studies on fermented but none for sale).
• Hypoglycemic effects of Rhodiola crenulata (HK. f. et. Thoms) H. Ohba in vitro and in vivo and its ingredient identification by UPLC-triple-TOF/MS - Food Funct 2022 Jan 26 - "Rhodiola crenulata (HK. f. et. Thoms) H. Ohba (RC), mainly distributed in the highly cold region of China, has long been used as a medicine/healthy food for eliminating fatigue and increasing blood circulation ... The results demonstrate that the RCRS extract of Rhodiola crenulata could be employed as a healthy food or medicine for controlling postprandial blood glucose levels" - See Rhodiola crenulata at Amazon.com.
  • Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles - Bull Exp Biol Med 2003 Dec - "Experiments proved different pharmacological characteristics of R. rosea and R. crenulata: R. rosea is most effective for improving physical working capacity"
• Neuroprotective effects of salidroside on ageing hippocampal neurons and naturally ageing mice via the PI3K/Akt/TERT pathway - Phytother Res 2021 Aug 9 - "Studies have found that salidroside, isolated from Rhodiola rosea L, has various pharmacological activities, but there have been no studies on the effects of salidroside on brain hippocampal senescence ... our findings suggest that salidroside has the potential to be used as a therapeutic strategy for anti-ageing and ageing-related disease treatment" - See Rhodiola rosea at Amazon.com and iHerb.
• A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers - Nutr Neurosci 2021 Apr 26 - "Green tea and rhodiola have been shown to modulate EEG oscillatory brain activity associated with relaxation and stress perception ... The combined treatment significantly increased EEG resting state theta (p < .02) - considered indicative of a relaxed, alert state, attenuated subjective stress, anxiety and mood disturbance, and heightened subjective and autonomic arousal ... Conclusions: Mg, B vitamins, rhodiola and green tea extracts are a promising combination of ingredients that may enhance coping capacity and offer protection from the negative effects of stress exposure" - See green tea extract at Amazon.com, rhodiola rosea at Amazon.com, Magtein at Amazon.com and B complex supplements at Amazon.com.
• Effects of a Rhodiola rosea extract on mental resource allocation and attention: An event‐related potential dual task study - Phytother Res 2020 Jun 27 - "A total of 50 adult participants were treated with 2 × 200 mg R. rosea extract (Rosalin®, WS® 1,375) for 12 weeks and were subjected to a neuropsychological test battery as well as an event-related brain potential measurement in a dual task paradigm prior to administration, after 6 weeks and after 12 weeks. The study followed a single-arm open-label design. Reaction times improved for the attention network task (ANT), the Go/Nogo task, and the divided attention task. Moreover, the orienting effect and the executive effect in the ANT showed an improvement. The P3 component in a dual task paradigm was increased in amplitude. The results of this pilot study show an improvement of mental speed and moreover, suggest improved mental resources" - [Nutra USA]
• Actaea racemosa L. Is More Effective in Combination with Rhodiola rosea L. for Relief of Menopausal Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study - Pharmaceuticals (Basel). 2020 May; 13(5): 102 - "The aim of this study was to assess the efficacy and safety of a new herbal preparation (Menopause Relief EP®), the hybrid combination of Actaea racemosa L. (black cohosh, BC) and Rhodiola rosea L. (RR) root extracts, compared with the most effective dose of BC extract in women with menopausal complaints ... A total of 220 women were randomly assigned to receive two capsules either BC (6.5 mg), BC500 (500 mg), Menopause Relief EP® (206,5), or placebo once per day for 12 weeks. The efficacy endpoints were relief of menopausal symptoms, measured using the Kupperman Menopausal Index (KMI), Menopause Relief Score (MRS), and menopause Utian Quality of Life (UQOL) index ... The menopause symptom relief effects of RR-BC were significantly superior in all tests to the effects of BC and placebo after their repeated administration for 6 and 12 weeks. There was no statistically significant difference between the effects of BC and BC500 over time. RR-BC significantly improved the QOL index in patients, compared to BC, BC500, and placebo, mainly due to the beneficial effects on the emotional and health domains ... BC is more effective in combination with RR in relief of menopausal symptoms, particularly psychological symptoms" - [Nutra USA] - See black cohosh at Amazon.com and iHerb and Rhodiola rosea at Amazon.com and iHerb.
• Tyrosol Reduces Amyloid-β Oligomer Neurotoxicity and Alleviates Synaptic, Oxidative, and Cognitive Disturbances in Alzheimer's Disease Model Mice - J Alzheimers Dis. 2019 Jun 21 - "Rhodiola rosea extracts and one of its main constituents, tyrosol, significantly inhibited AβO-induced caspase-3 activation ... Immunohistochemical analysis revealed that the immunoreactivity of spinophilin, a dendritic synaptic protein, was significantly reduced in three hippocampal subregions of vehicle-treated AD mice compared with non-transgenic mice, which was reversed in tyrosol-treated AD mice. Tyrosol treatment also prevented the enhancement of 4-hydroxy-2-nonenal immunoreactivity in the hippocampal CA3 region of AD mice. By contrast, tyrosol administration did not affect Aβ accumulation, as evaluated by immunohistochemical and biochemical analyses. Moreover, the Barnes maze test showed that tyrosol administration modestly mitigated spatial memory impairment in AD mice. These findings collectively indicate that the natural agent tyrosol protects neurons against AβO neurotoxicity in vitro and ameliorates synaptic disturbance, oxidative stress responses, and cognitive impairment in vivo. We thus suggest that tyrosol is potentially an effective, safe, and unique drug candidate for AD"
• Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms - Neuropsychiatr Dis Treat. 2017; 13: 889–898 - "The majority of the outcome measures showed clear improvement over time. Several parameters had already improved after 1 week of treatment and continued to improve further up to the end of the study. The incidence of adverse events was low with 0.015 events per observation day" - [Nutra USA]
• The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms - Phytother Res. 2015 Oct 27 - "Rhodiola rosea L (2 × 200 mg dose Vitano®, 1 tablet taken before breakfast and 1tablet before lunch) or a control condition (no treatment) ... Relative to the controls, the experimental group demonstrated a significant reduction in self-reported, anxiety, stress, anger, confusion and depression at 14 days and a significant improvements in total mood"
• Prevention of Torsion-induced Testicular Injury by Rhodiola rosea - Urology. 2013 Jul;82(1):254.e1-254.e6 - "R. rosea extract was shown to have partially preventive effects on testicular injury induced by torsion in this rat model" - See Rhodiola rosea at Amazon.com.
• Evaluation of Rhodiola crenulata and Rhodiola rosea for management of Type II diabetes and hypertension - Asia Pac J Clin Nutr. 2006;15(3):425-32 - "The ability of the above Rhodiola extracts to inhibit rabbit lung angiotensin I-converting enzyme (ACE) was investigated. The ethanol extracts of R.rosea had the highest ACE inhibitory activity (38.5 %) followed by water extract of R.rosea (36.2 %) and R.crenulata (15.4 %)"