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-
Does Ashwagandha
supplementation have a beneficial effect on the management of anxiety and
stress? A systematic review and meta-analysis of randomized controlled trials
- Phytother Res 2022 Aug 25 - "Ashwagandha supplementation significantly reduced
anxiety (SMD: -1.55, 95% CI: -2.37, -0.74; p = .005; I2 = 93.8%) and stress
level (SMD: -1.75; 95% CI: -2.29, -1.22; p = .005; I2 = 83.1%) compared to the
placebo. Additionally, the non-linear dose-response analysis indicated a
favorable effect of Ashwagandha supplementation on anxiety until 12,000 mg/d and
stress at dose of 300-600 mg/d" - See
ashwagandha at Amazon.com.
-
Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of
life and sleep in adults with self-reported poor sleep: A randomised,
double-blind, placebo-controlled study - J Func Foods, Oct 2021 -
"immunoglobulin A (sIgA), α-amylase (sAA) ... Based on
the Bergen Insomnia Scale, Bacopa monnieri did not improve sleep patterns more
than the placebo; however, it was associated with greater improvements in
emotional wellbeing, general health, and pain-related symptoms. Bacopa monnieri
was also associated with greater reductions in sIgA and sAA compared to the
placebo" - [Nutra USA] - See
Bacopa monnieri at
Amazon.com and
iHerb.
-
Effects of Probiotic NVP-1704
on Mental Health and Sleep in Healthy Adults: An 8-Week Randomized,
Double-Blind, Placebo-Controlled Trial - Nutrients 2021, 13(8) -
"The human gut microbiome is closely linked to mental
health and sleep. We aimed to verify the efficacy and safety of probiotic
NVP-1704, a mixture of Lactobacillus reuteri NK33 and Bifidobacterium
adolescentis NK98, in improving stress, depression, anxiety, and sleep
disturbances, along with the measurement of some blood biomarkers. A total of
156 healthy adults with subclinical symptoms of depression, anxiety, and
insomnia were retrospectively registered and randomly assigned to receive either
NVP-1704 (n = 78) or a placebo (n = 78) for eight week ... After intervention,
gut microbiota composition was quantified by pyrosequencing the bacterial 16S
rRNA gene. The NVP-1704 group had a more significant reduction in depressive
symptoms at four and eight weeks of treatment, and anxiety symptoms at four
weeks compared to the placebo group. Those receiving NVP-1704 also experienced
an improvement in sleep quality. NVP-1704 treatment led to a decrease in serum
interleukin-6 levels. Furthermore, NVP-1704 increased Bifidobacteriaceae and
Lactobacillacea, whereas it decreased Enterobacteriaceae in the gut microbiota
composition. Our findings suggest that probiotic NVP-1704 could be beneficial
for mental health and sleep" - [Nutra
USA] - See probiotic supplements at Amazon.com
and
iHerb.
-
Therapeutic effects of
saffron extract on different memory types, anxiety, and hippocampal BDNF and
TNF-α gene expressions in sub-chronically stressed rats - Nutr Neurosci 2021
Jun 24 - "Compared to the low saffron dose, the high
dose had a latent but long-lasting impact. Cognitive and spatial memories
remained unaffected by either stress or saffron treatment. In addition, only the
high saffron dose reversed anxiety in the sub-chronically stressed group. These
findings suggest that various doses of saffron act differently on different
brain functions under sub-chronic stress condition" - See
saffron supplements at Amazon.com.
-
A combination of green tea,
rhodiola, magnesium and B vitamins modulates brain activity and protects against
the effects of induced social stress in healthy volunteers - Nutr Neurosci
2021 Apr 26 - "Green tea and
rhodiola have been shown to
modulate EEG oscillatory brain activity associated with relaxation and
stress
perception ... The combined treatment significantly increased EEG resting state
theta (p < .02) - considered indicative of a relaxed, alert state, attenuated
subjective stress, anxiety and mood disturbance, and heightened subjective and
autonomic arousal ... Conclusions: Mg, B vitamins, rhodiola and green tea
extracts are a promising combination of ingredients that may enhance coping
capacity and offer protection from the negative effects of stress exposure"
- See green tea extract at Amazon.com,
rhodiola rosea at Amazon.com,
Magtein at Amazon.com
and
B complex supplements at Amazon.com.
-
Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to
a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel
Group, Clinical Trial - Front Nutr 2021 Feb 1 -
"Anxiety, stress, and low mood are closely related and may contribute to
depressive symptoms. Among non-pharmacological solutions to improve subclinical
mood symptoms and resilience to stress, natural products such as
saffron—identified as promising following preliminary beneficial effects in
major depressive disorder—represent a relevant strategy. This study aimed to
assess the efficacy of 8 weeks' supplementation with 30 mg standardized saffron
extract on emotional well-being in healthy adults with subclinical feelings of
low mood and anxiety and/or stress and evaluate the acute effect of saffron in
response to a lab-based psychosocial stressor. The study adopted a double-blind,
randomized, parallel groups design in which 56 healthy male and female
individuals (18–54 years) received either a saffron extract or a placebo for 8
weeks ... Participants who received the saffron extract reported reduced
depression scores and improved social relationships at the end of the study.
Urinary crocetin levels increased significantly with saffron supplementation and
were correlated with change in depression scores. The typical stress-induced
decrease in heart rate variability (HRV) during exposure to the stressor was
attenuated following acute saffron intake. Saffron extract appears to improve
subclinical depressive symptoms in healthy individuals and may contribute to
increased resilience against the development of stress-related psychiatric
disorders." - [Nutra
USA] - See saffron supplements at Amazon.com.
-
Lacticaseibacillus paracasei Lpc-37® improves psychological and physiological
markers of stress and anxiety in healthy adults: a randomized, double-blind,
placebo-controlled and parallel clinical trial (the Sisu study) - Neurobiol
Stress. 2020 Nov 24 - "Chronic stress is a risk-factor
for the development of mood and stress-related disorders. Clinical evidence
indicates that probiotics can influence the stress response and mood. The Sisu
study investigated whether Lacticaseibacillus paracasei Lpc-37® (Lpc-37®) could
modulate stress, mood and well-being. Prior to a two-week run-in period, 120
healthy adults (18-45 y) were stratified for sex and chronic stress and
randomized to either 1.75 × 1010 colony forming units (CFU) of Lpc-37 or placebo
(1:1) per day for 5 weeks. The primary objective was the effect of Lpc-37 on
heart rate (HR) in response to the Trier Social Stress Test (TSST). Secondary
objectives were assessed by biomarkers and self-report scales over the study.
The primary hypothesis was not met in either the Intention-to-Treat (ITT) or Per
Protocol (PP) population, but Lpc-37 reduced the increase in HR in participants
with low chronic stress (LCS) and increased HR in participants with high chronic
stress (HCS) during the TSST. Supporting significant efficacy in the PP
population (n = 113), Lpc-37 reduced perceived stress following intervention.
More significant effects were identified within the subgroups where Lpc-37
reduced exhaustion during the TSST and normalized cortisol levels at 8pm in
participants with LCS, reduced perceived stress also in females, and increased
perceived health and sleep-related recovery in participants with HCS. Adverse
events (AEs) were similar between groups, there were no severe AEs, and vital
signs remained unchanged" - [Nutra
USA] - See probiotic supplements at Amazon.com.
-
Lactobacillus plantarum
DR7 alleviates stress and anxiety in adults: a randomised, double-blind,
placebo-controlled study - Benef Microbes. 2019 Apr 19 -
"One hundred and eleven (n=111; DR7 n=56, placebo n=55)
stressed adults were recruited based on moderate stress levels using the PSS-10
questionnaire. The consumption of DR7 (1×109 cfu/day) for 12 weeks reduced
symptoms of stress (P=0.024), anxiety (P=0.001), and total psychological scores
(P=0.022) as early as 8 weeks among stressed adults compared to the placebo
group as assessed by the DASS-42 questionnaire. Plasma cortisol level was
reduced among DR7 subjects as compared to the placebo, accompanied by reduced
plasma pro-inflammatory cytokines, such as interferon-γ and transforming growth
factor-α and increased plasma anti-inflammatory cytokines, such as interleukin
10 (P<0.05). DR7 better improved cognitive and memory functions in normal adults
(>30 years old), such as basic attention, emotional cognition, and associate
learning (P<0.05), as compared to the placebo and young adults (<30 years old).
The administration of DR7 enhanced the serotonin pathway, as observed by lowered
expressions of plasma dopamine β-hydroxylase (DBH), tyrosine hydroxylase (TH),
indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase accompanied by
increased expressions of tryptophan hydroxylase-2 and 5-hydroxytryptamine
receptor-6, while stabilising the dopamine pathway as observed via stabilised
expressions of TH and DBH over 12 weeks as compared to the placebo" - [Nutra
USA] - See
probiotic products at Amazon.com.
-
Efficacy and safety of Eurycoma longifolia (Physta®) water extract plus
multivitamins on quality of life, mood and stress: a randomized
placebo-controlled and parallel study - Food and Nutri, 10/18 -
"While there were no significant between-group
differences, within-group improvements were observed in the SF-12 QoL, POMS and
MMSQ domains. In the SF-12 domain, improvements were seen in role limitation due
to emotional health (P = 0.05), mental component domain (P < 0.001), emotional
well-being (P < 0.001), social functioning (P = 0.002) as well as vitality (P =
0.001) at week 12. An increasing trend in POMS-vigour domain was also observed
in the EL+MV group at week 12. A 15%
decrease in physical stress domain (P < 0.05) compared with 0.7% in the placebo
group was also observed in MMSQ" - [Nutra
USA] - See Physta at Amazon.com.
-
Supplementation with
Robuvit® in subjects with burnout associated to high oxidative stress -
Minerva Med. 2018 Jun;109(3):211-217 - "This supplement
registry study evaluated the effect of supplementation with
Robuvit® on the burnout syndrome (BOS) of
patients with significant fatigue and high oxidative stress. Robuvit® (French
oak wood extract) is a standardized supplement, effective in treating chronic
fatigue syndrome (CFS), post-traumatic stress disorder (PTSD) and convalescence
... Subjects followed a standard management (SM); one half of the subjects
received 300 mg/day of Robuvit® for 4 weeks in addition to SM ... Robuvit® by
controlling fatigue (the primary symptom) and oxidative stress, relieves the
most important 'symptoms' associated with BOS. The effects are comparable in
young surgeons not accustomed to stress, as well as in professionals in
management positions who are used to control stress" - [Nutra
USA] - See
Robuvit® at
Amazon.com.
-
Memory enhancement of
fresh ginseng on deficits induced by chronic restraint stress in mice - Nutr
Neurosci. 2017 Sep 15:1-8 - "Chronic stress exposure can
disrupt the balance of organisms, result in learning and memory impairments and
induce oxidative stress ... Fresh ginseng (FG), an unprocessed raw root of
ginseng, has antioxidant and neuroprotective activities and has been used as
functional health food in Asian countries for many years ... Our results suggest
that FG treatment could improve CRS-induced learning and memory impairments and
oxidative stress damage. FG is an intriguing therapeutic agent and functional
health food in stress-related dementia"
-
Cannot
sleep due to stress? Here is the cure - Science Daily, 9/5/17 -
"Octacosanol reduced corticosterone level in blood
plasma, which is a stress marker. The octacosanol-administered mice also showed
normal sleep, which was previously disturbed due to stress. They therefore claim
that the octacosanol mitigates stress in mice and restores stress-affected sleep
to normal in mice. The sleep induced by octacosanol was similar to natural sleep
and physiological in nature. However, authors also claimed that octacosanol does
not affect sleep in normal animals. These results clearly demonstrated that
octacosanol is an active compound that has potential to reduce stress and to
increase sleep, and it could potentially be useful for the therapy of insomnia
caused by stress" - See
policosanol at Amazon.com.
-
Supplementation with
macular carotenoids reduces psychological stress, serum cortisol, and
sub-optimal symptoms of physical and emotional health in young adults -
Nutr Neurosci. 2017 Feb 15:1-11 - "Oxidative stress
and systemic inflammation are the root cause of several deleterious effects
of chronic psychological stress. We hypothesize that the antioxidant and
anti-inflammatory capabilities of the macular carotenoids (MCs) lutein,
zeaxanthin, and meso-zeaxanthin could, via daily supplementation, provide a
dietary means of benefit ... Supplementation with the MCs significantly
reduces stress, cortisol, and symptoms of sub-optimal emotional and physical
health" - See carotenoids supplement
at Amazon.com.
-
Common probiotics can reduce stress levels, lessen anxiety - Science
Daily, 11/21/16 - "a common probiotic sold in
supplements and yogurt can decrease stress-related behavior and anxiety ...
bacteria in the gut altered the gene expression associated with stress- and
anxiety-related pathways in the fish allowing for increased signaling of
particular neurotransmitters" - See
probiotic products at Amazon.com.
-
Early supplementation may help offset early-life stress on the adult brain
- Science Daily, 10/26/16 - "Specifically, using
mice, scientists focused on essential micronutrients, including methionine,
vitamins B6and B12, and folic acid, none of which are made by the body and
need to be ingested through diet. They found that early-life stress reduces
the levels of these nutrients in mouse pups, but supplementation prevented
the reduction of methionine levels and even prevented some of the lasting
negative effects of early-life stress on later learning and memory in adult
offspring ... Here we see strikingly beneficial cognitive effects of a sound
postnatal diet. The nutrients tested were familiar ones, but the results
speak for themselves"
- Early
micronutrient supplementation protects against early stress-induced
cognitive impairments - FASEB J. 2016 Oct 21 -
"Early-life stress (ES) impairs cognition later in life. Because ES
prevention is problematic, intervention is needed, yet the mechanisms that
underlie ES remain largely unknown ... In conclusion, nutrition is important
in brain programming by ES. A short, early supplementation with essential
micronutrients can already prevent lasting effects of ES"
- Safety, Tolerance,
and Enhanced Efficacy of a Bioavailable Formulation of Curcumin With
Fenugreek Dietary Fiber on Occupational Stress: A Randomized, Double-Blind,
Placebo-Controlled Pilot Study - J Clin Psychopharmacol. 2016 Apr 2 -
"CurQfen (curcumagalactomannoside [CGM]), a
food-grade formulation of natural curcumin with fenugreek dietary fiber that
has shown to possess improved blood-brain-barrier permeability and tissue
distribution in rats. In this randomized double-blinded and
placebo-controlled trial, 60 subjects experiencing occupational
stress-related anxiety and fatigue were randomized to receive CGM, standard
curcumin, and placebo for 30 days (500 mg twice daily). The study
demonstrated the safety, tolerance, and enhanced efficacy of CGM in
comparison with unformulated standard curcumin. A significant improvement in
the quality of life (P < 0.05) with considerable reduction in stress (P <
0.001), anxiety (P < 0.001), and fatigue (P < 0.001) was observed among
CGM-treated subjects as compared with the standard curcumin group, when
monitored by SF-36, Perceived Stress Scale with 14 items, and Beck Anxiety
Inventory scores. Improvement in the quality of life was further correlated
with the significant enhancement in endogenous antioxidant markers (P <
0.01) and reduction in lipid peroxidation (P < 0.001). Further comparison of
the free curcuminoids bioavailability after a single-dose (500 mg once per
day) and repeated-dose (500 mg twice daily for 30 days) oral administration
revealed enhanced absorption and improved pharmacokinetics of CGM upon both
single- (30.7-fold) and repeated-dose (39.1-fold) administrations" -
[Nutra
USA] - See CurQfen at Amazon.com.
- The
Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other
Mood Symptoms - Phytother Res. 2015 Oct 27 -
"Rhodiola rosea L (2 × 200 mg dose Vitano®, 1 tablet taken before breakfast
and 1tablet before lunch) or a control condition (no treatment) ... Relative
to the controls, the experimental group demonstrated a significant reduction
in self-reported, anxiety, stress, anger, confusion and depression at 14
days and a significant improvements in total mood" - See
Rhodiola rosea at Amazon.com.
- Nutrient
Supplements Ease Anxiety, Stress Due to Disasters - Medscape, 7/15/15 -
"Seventeen participants were randomly assigned to
receive vitamin D supplementation (1000 IU in one capsule daily); 21 were
assigned to a regimen with "few nutrients" consisting of a vitamin B–complex
supplement containing B6, B12, thiamine, riboflavin, folate, d-pantothenic
acid, intrinsic factor, biotin, and niacin (one capsule daily); and 18
received a broad-spectrum mineral and vitamin (BSMV) formula (four capsules
daily). Overall compliance with the nutrient supplements during the 6-week
study period was high in all three groups (roughly 93%) ... throughout the 6
weeks, all groups showed substantial decreases on all measures, but those
taking the B-complex or the BSMV formulas showed significantly greater
improvement in stress and anxiety levels relative to those taking only
vitamin D, with "large" effect sizes (Cohen's d range, 0.76 - 1.08)"
-
Acute mood but not cognitive improvements following administration of a
single multivitamin and mineral supplement in healthy women aged 50 and
above: a randomised controlled trial - Age (Dordr). 2015 Jun;37(3):9782
- "This study investigated the acute effects of a
single multivitamin and mineral and herbal (MVMH) supplement versus placebo
on self ratings of mood and the performance of an effortful computerised
cognitive battery in a sample of 76 healthy women aged 50-75 years. Mood was
assessed using the depression anxiety stress scale (DASS), state trait
anxiety inventory-state anxiety scale and visual analogue scales (VAS). Mood
was rated at 1 h post supplementation and again after the competition of the
cognitive assessments at 2 h post supplementation. It was demonstrated that
the MVMH supplement improved overall DASS mood ratings; however, the most
prominent effects appeared to be a reduction in ratings of perceived mental
stress ... Supplementation with a single multivitamin, mineral and herbal
supplement reduces stress several hours after intake in healthy older
people"
-
Want a better work-life balance? Exercise, study finds - Science Daily,
1/9/14 - "Individuals who exercised regularly were
more confident they could handle the interaction of their work and home life
and were less likely to be stressed at work ... The idea sounds
counterintuitive. How is it that adding something else to our work day helps
to alleviate stress and empower us to deal with work-family issues? We think
exercise is a way to psychologically detach from work -- you're not there
physically and you're not thinking about it either -- and, furthermore, it
can help us feel good about ourselves ... Researchers examined responses of
476 working adults to survey questions ... Our findings suggest that
employers can help employees with work-life balance by encouraging them to
exercise"
-
Effect of Magnolia officinalis and Phellodendron amurense (Relora(R)) on
cortisol and psychological mood state in moderately stressed subjects -
J Int Soc Sports Nutr. 2013 Aug 7;10(1):37 -
"Magnolia (Magnolia officinalis) and Phellodendron (Phellodendron amurense)
barks are medicinal plants commonly used as traditional remedies for
reducing stress and anxiety ... assessed salivary cortisol exposure and
psychological mood state in 56 subjects (35 men and 21 women) screened for
moderate stress and supplemented with a standardized/patented MP combination
(Relora(R), Next Pharmaceuticals) or Placebo for 4 weeks ... After 4 weeks
of supplementation, salivary cortisol exposure was significantly (p<0.05)
lower (-18%) in the Relora group compared to Placebo. Compared to Placebo,
the Relora group had significantly better (p<0.05) mood state parameters,
including lower indices of Overall Stress (-11%), Tension (-13%), Depression
(-20%), Anger (-42%), Fatigue (-31%), and Confusion (-27%), and higher
indices of Global Mood State (+11%) and Vigor (+18%)" - Note: The
biggest affect was on anger (-42%). - See
Relora at Amazon.com.
-
Fish oil may help the heart beat mental stress - Science Daily, 5/22/13
- "volunteers who took fish oil supplements for
several weeks had a blunted response to mental stress in several
measurements of cardiovascular health, including heart rate and muscle
sympathetic nerve activity (MSNA), part of the "fight or flight" response,
compared to volunteers who took olive oil instead. The results may explain
why taking fish oil could be beneficial to the heart and might eventually
help doctors prevent heart disease in select populations" -
See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
-
Probiotics reduce stress-induced intestinal flare-ups, study finds -
Science Daily, 3/14/13 - "while stress does not
cause IBS, it does alter brain-gut interactions and induces the intestinal
inflammation that often leads to severe or chronic belly pain, loss of
appetite and diarrhea ... Stress has a way of suppressing an important
component called an inflammasome which is needed to maintain normal gut
microbiota, but probiotics reversed the effect in animal models ... The
effect of stress could be protected with probiotics which reversed the
inhibition of the inflammasome" - See
probiotic products at Amazon.com.
-
Antioxidant Ingredient Proven To Relieve Stress - Science Daily, 9/14/09
- "The 35 people in our study who received capsules
containing superoxide dismutase showed improvement in several signs and
symptoms of perceived stress and fatigue" - See
SOD supplements at Amazon.com.
- Best stress relievers
- MSNBC, 2/5/06
- Stress-Busting
Help Comes From Hormone - WebMD, 8/2/04 -
"The people who reported fewer symptoms and who
performed best at their military tasks had "significantly higher" levels of
the hormone DHEA-S compared with cortisol"
[Abstract]
- See
DHEA at Amazon.com.
-
Stress, Cortisol and Health - Supplement Watch Newsletter, 10/02 -
"several lines of evidence have converged to
solidify the concept that stress makes us fat (because of
cortisol), thins our bones (because of cortisol), shrinks our brains
(because of cortisol), suppresses our immune system (because of cortisol),
saps our energy levels (because of cortisol), and kills our sex drive
(because of cortisol) ... Take a daily multivitamin/multi-mineral supplement
- because calcium,
magnesium, vitamin C and
B-complex vitamins are needed for a proper stress response ... Chief
among the supplements with documented cortisol-controlling effects are
Phosphatidylserine, Beta-sitosterol,
Magnolia bark, Theanine,
Epimedium, Ashwagandha and
Passionflower"
- Putting the Reins
on Stress - WebMD, 9/5/02
-
Stress: The Hidden Factor For Weight Gain - Natural Foods Merchandiser,
4/02
-
The
Ultimate Relaxant - Life Extension Magazine, 1/02 -
"Theanine is an amino
acid found in green tea. It helps to produce a calming effect in the brain
and induces a feeling of relaxation and well-being. Best of all, it does all
of this without causing drowsiness. In fact, studies have shown that
theanine enhances the ability to learn and remember. One of the other
benefits of this amino acid is that it helps to lower blood pressure
naturally, by enhancing GABA in the brain"
-
Stress: The Hidden Factor For Weight Gain - Nutrition Science News, 4/01
Other News:
-
Stress May Turn Hair
Gray, but Calm May Reverse It - Medscape, 7/8/21 -
"They developed a mathematical model to predict what
might happen to human hair over time and suggest there is a point in a
person's life when stress can temporarily induce loss of color, but that can
be reversed if tensions ease"
-
Stressful jobs are associated with a higher risk of heart rhythm disorders
- Science Daily, 6/4/18 - "The study found that
being stressed at work was associated with a 48% higher risk of atrial
fibrillation, after adjustment for age, sex, and education"
-
Stress Can Make the Pounds Accumulate - NYT, 3/1/17 -
"After controlling for age, sex, ethnicity, smoking,
diabetes and other factors that might be linked to obesity, they found that
the higher the level of cortisol, the greater the body weight, B.M.I. and
waist circumference. Higher cortisol levels were also associated with
persistence of obesity over time"
-
Why being tired makes us look ugly - nbcnews.com, 12/19/12 -
"Stress causes a drop in the skin’s ability to
protect itself ... And stress can also lead to less melanin, causing that
jaundiced, haggard look. Melanin pigments the skin, giving humans their
complexion ... Not sleeping causes us to accumulate water under our eyes,
giving us that extra "baggage" ... What you get from stress is the wrinkles
of aging .. Stress causes you to age ... stress not only causes wrinkles on
the face but wrinkles in your arteries, as well, which can cause serious
problems at an earlier age ... Your cells are biologically 10 to 15 years
older … if you are chronically stressed ... If you are 45, the cells signal
as if they are 60 years old"
-
Does
depression contribute to the aging process? - Science Daily, 2/21/12 -
"telomere length was shorter in the depressed
patients, which confirmed prior findings. Importantly, they also discovered
that shorter telomere length was associated with a low cortisol state in
both the depressed and healthy groups ... stress plays an important role in
depression, as telomere length was especially shortened in patients
exhibiting an overly sensitive HPA axis. This HPA axis response is something
which has been linked to chronic stress and with poor ability to cope with
stress" - Note: I'm not sure if that's correct because depressed
people usually have high cortisol, not low cortisol. I read somewhere that
PTSD was associated with low cortisol.
-
Anticipation of stressful situations accelerates cellular aging -
Science Daily, 2/21/12 - "The researchers assessed
cellular age by measuring telomeres, which are the protective caps on the
ends of chromosomes. Short telomeres index older cellular age and are
associated with increased risk for a host of chronic diseases of aging,
including cancer, heart disease and stroke ... higher levels of anticipated
threat in daily life may promote cellular aging in chronically stressed
individuals"
-
Depression and chronic stress accelerates aging - Science Daily, 11/9/11
- "The telomere is the outermost part of the
chromosome. With increasing age, telomeres shorten, and studies have shown
that oxidative stress and inflammation accelerates this shortening. On this
basis it has been suggested that telomere length is a measure of biological
aging, and telomere length has subsequently been linked to age-related
diseases, unhealthy lifestyle, and longevity. The research team shows that
shorter telomere length is associated with both recurrent depression and
cortisol levels indicative of exposure to chronic stress"
-
At
last, a reason why stress causes DNA damage - Science Daily, 8/21/11
-
Stress can affect future offspring - Science Daily, 8/16/11
-
Stress may increase risk for Alzheimer's disease - Science Daily,
5/26/11 - "Fewer than ten percent of Alzheimer cases
have a genetic basis. The factors that contribute to the rest of the cases
are largely unknown ... life events (stress) may be one trigger ... stress,
and the hormones released during stress, can accelerate the development of
Alzheimer disease-like biochemical and behavioural pathology"
-
Social isolation, stress-induced obesity increases breast cancer risk in
mice - Science Daily, 4/4/11 - "Stress from
social isolation, combined with a high-fat diet, increases levels of a brain
neurotransmitter -- neuropeptide Y, or NPY -- in mice that then promotes
obesity, insulin resistance, and breast cancer risk ... To conduct the
study, the researchers used female mice that develop breast cancer when
given progesterone and a carcinogen. They established four groups of these
mice: one group that lived together (not socially isolated) and ate a normal
diet; a group that was isolated (each alone in a cage) and ate normally; an
isolated group that ate a high-fat diet, and a group that lived together and
ate a high-fat diet ... Ten weeks after treatment and living in these
environments (for a total of 17 weeks), 92 percent of the socially-isolated
mice fed a high-fat diet had developed tumors, compared to 36 percent of
socially-isolated mice fed a normal diet and 36 percent of grouped mice that
were also fed normally. But 67 percent of mice who were happy in group
homes, but were fed a high fat diet, developed breast cancer"
-
Even
mild stress is linked to long-term disability, study finds - Science
Daily, 3/23/11 - "Between 2002 and 2007, the authors
tracked the health of more than 17,000 working adults up to the age of 64,
who had been randomly selected from the population in the Stockholm area ...
Higher levels of stress at the start of the study were associated with a
significantly greater likelihood of subsequently being awarded long term
disability benefits ... But even those with mild stress were up to 70% more
likely to receive disability benefits ... One in four of these benefits
awarded for a physical illness, such as high blood pressure, angina, and
stroke, and almost two thirds awarded for a mental illness, were
attributable to stress"
-
Simple spit and blood tests might detect burnout before it happens -
Science Daily, 2/21/11 - "In addition to
professional and personal suffering, burnout puts distressed workers at
further risk of physical and psychological problems if ignored ... We
hypothesized that healthy workers with chronic stress and with mild burnout
symptoms would have worse physiological dysregulations and lower cortisol
levels -- a profile consistent with burnout ... Cortisol is a stress hormone
involved in our bodies stress response and naturally as part of our body's
daily rhythm. Cortisol levels are often high in people suffering from
depression, while it tends to be low in cases of burnout. Too much cortisol
can be as bad as too little when it comes to both mental and physical health
... Critically, people with burnout are often treated with anti-depressant
medications that lower cortisol levels. If cortisol is already lower than it
should be, this course of treatment could represent a therapeutic mistake.
"The use of an allostatic load index gives researchers and clinicians a
window to see how chronic stress is straining the person"
-
Casualties of war: Wounded veterans more likely to die of coronary heart
disease - Science Daily, 1/26/11 - "During the
28 year follow up , out of 412 deaths, 140 were due to coronary heart
disease (CHD), making wounded veterans 1.7 times more likely to die from CHD
than the comparison group ... those who had been wounded in action had a
higher BMI, a greater history of self-reported depression and were more
likely to be claiming disability pension. This also suggests that as well as
increased risk of PTSD, physical trauma in early life may cause longstanding
physiological implications"
-
Social stress leads to atherosclerosis, research suggests - Science
Daily, 12/6/10
-
Stress accelerates breast cancer progression in mice, researchers find -
Science Daily, 9/15/10 - "stress is biologically
reprogramming the immune cells that are trying to fight the cancer,
transforming them instead from soldiers protecting the body against disease
into aiders and abettors. The study found a 30-fold increase in cancer
spread throughout the bodies of stressed mice compared to those that were
not stressed ... Beta blockers, used in this study to shut down the stress
pathways in the mice, are currently being examined in several large breast
cancer databases for their role in potential prevention of recurrence and
cancer spread ... using beta blockers in stressed mice prevented the same
cancer progression seen in the stressed mice that did not receive
medication"
-
Hair
provides proof of the link between chronic stress and heart attack -
Science Daily, 9/3/10 - "Cortisol is considered to
be a stress hormone. Its secretion is increased during times of stress.
Traditionally it's been measured in serum, urine and saliva, but that only
shows stress at the time of measurement, not over longer periods of time.
Cortisol is also captured in the hair shaft"
-
Seeing family for the holidays? Scientists discover how the stress might
kill you - Science Daily, 11/30/09
-
Prolonged Stress Sparks Endoplasmic Reticulum To Release Calcium Stores And
Induce Cell Death In Aging-related Diseases - Science Daily, 9/27/09
-
Stress Raises Belly Fat, Heart Risks - WebMD, 8/6/09 -
"Even compared to other monkeys with the same body
mass index and weight, CT scans showed that the stressed monkeys had a great
deal more belly fat. And when the researchers looked at the animals'
arteries, they found plaque clogging the arteries of the stressed monkeys
... it's not how much fat you have, but where it is located ... Over time,
high cortisol levels cause belly fat to accumulate. It also makes individual
fat cells get larger ... When you have lots more fat in visceral fat cells
and all the characteristics of the metabolic syndrome, each of these things
promotes atherosclerosis"
-
Life's Stress May Lead to Weight Gain - WebMD, 7/8/09
-
Stress Makes Your Hair Go Gray - Science Daily, 6/11/09 -
"Those pesky graying hairs that tend to crop up with
age really are signs of stress, reveals a new report in the journal Cell"
-
Symptoms Of Depression Associated With Increase In Abdominal Fat -
Science Daily, 12/1/08 - "There are several
mechanisms by which depression might increase abdominal fat, they note.
Chronic stress and depression may activate certain brain areas and lead to
increased levels of the hormone cortisol, which promotes the accumulation of
visceral fat. Individuals with depression may have unhealthier lifestyles,
including a poor diet, that could interact with other physiological factors
to produce an increase in abdominal obesity" - See my
cortisol page for ways to reduce it. Cortisol
is like the chicken and the egg with depression. They don't seem to know
whether it is the cause or result.
-
Psychological Distress May Increase Risk of Breast Cancer - Medscape,
9/15/08 - "The team evaluated interactions between
breast cancer and severe life events -- such as loss of a parent or divorce
of parents before age 20, or loss of a close relative or spouse -- and mild
to moderate life events -- e.g., separation from a spouse, loss of a job, an
economic crisis, or severe illness in a close relative ... Multivariate
analysis revealed a positive association (odds ratio, 1.62) between exposure
to more than one adverse life event and breast cancer. "It wasn't enough to
be exposed to one life event, a woman had to be exposed to more than one
event,""
-
Neurogenesis In Adult Brain: Association With Stress And Depression -
Science Daily, 8/31/08 - "Chronic stress can affect
the brain and lead into depression"
-
Stress Hormone Found To Regulate Brain Neurotransmission - Science
Daily, 8/7/08 - "When we are subjected to a stress,
our adrenal glands secrete hormones that affect our entire body. One of
these hormones, cortisol, enables us to adapt physically and mentally to the
stimulus. Following a major or repeated stress that the individual has no
control over, however, cortisol is secreted in great quantities over a long
period of time. This hypersecretion has damaging effects on the individual,
to the point of accelerating aging and facilitating the onset of illnesses
such as depression"
-
Stress May Increase A Woman's Risk Of Developing Cervical Cancer -
Science Daily, 2/15/08
-
Stress At Work Is Linked To Heart Disease - Science Daily, 1/22/08 -
"chronic work stress was associated with CHD and
this association was stronger among both men and women aged under 50 --
their risk of CHD was an average of 68% more than for people who reported no
stress at work"
-
Sept. 11 Stress Increases Risk Of Heart Problems, Study Suggests -
Science Daily, 1/7/08 - "Our study is the first to
show that even among people who had no personal connection to the victims,
those who reported high levels of post-traumatic stress symptoms in the days
following the 9/11 attacks were more than twice as likely to report being
diagnosed by their doctors with cardiovascular ailments like high blood
pressure, heart problems and stroke up to three years later"
-
Depression
Associated With Low Bone Mineral Density - Medscape, 12/3/07 -
"The novelty of this study is the fact that these
women were not severely depressed ... Depression is considered a disease of
chronic stress, Dr. Cizza said, with attendant increases in the stress
hormone cortisol, and cytokines produced by the immune system. "Those
substances are helpful to fight stress, but if there is too much cortisol or
cytokines, there are side effects," he said. "One of the side effects is
bone loss, so it was obvious to ask the question, 'do women with depression
have low bone mass?'""
-
Stress Hormone May Hasten The Progression Of Certain Blood Cancers -
Science Daily, 11/19/07
-
Feeling Stressed? How Your Skin, Hair And Nails Can Show It - Science
Daily, 11/12/07 - "When a person becomes stressed,
the level of the body’s stress hormone (cortisol) rises. This in turn causes
an increase in oil production, which can lead to oily skin, acne and other
related skin problems ... stress has a negative effect on the barrier
function of the skin, resulting in water loss that inhibits the skin’s
ability to repair itself after an injury"
-
Psychological Stress May Mar Skin WebMD, 11/1/07
-
How
Stress Harms the Heart - Time, 10/9/07
-
Stress Contributes To Range Of Chronic Diseases, Review Shows - Science
Daily, 10/9/07
-
High Hostility Linked with Poor Ability to Cope With Stress, Low HDL Levels
- Medscape, 8/30/07 - "individuals who were very
hostile were more likely to perceive problems as stressful and to cope with
stress by using interpersonal hostility, self-blame, and social isolation;
they also tended to have lower levels of HDL"
-
New Alzheimer's findings: High stress and genetic risk factor lead to
increased memory decline - Doctor's Guide, 8/27/07 -
"High stress levels may contribute to memory loss
among people at risk for developing Alzheimer's disease"
-
Coping With Stress Helps Cholesterol - WebMD, 8/20/07 -
"People who coped well had higher levels of HDL than
people who didn't cope well ... The amount of stress you deal with isn't as
important, they also found, as how you deal with it. "Stress doesn't matter
nearly as much as how you cope with it,""
-
Stress May Wreak Havoc on Your Mouth - WebMD, 8/13/07
-
Job Stress Jacks Up Blood Pressure - WebMD, 4/10/07 -
"Their blood pressure was highest on the job, when
they had 5.9/3.0 mm Hg higher blood pressure than the nonstressed workers
did. But the stressed-out workers also had higher blood pressure while at
home, including while they were sleeping"
-
Stress May Help Cancer Cells Stay Alive - Doctor's Guide, 4/10/07 -
"the stress hormone epinephrine causes changes in
prostate and breast cancer cells that may make them resistant to cell death"
-
Reactions to Stress May Affect Brain Aging - Medscape, 8/14/06 -
"the adrenal stress hormone cortisol appears to play
an important role in mediating the effects of stress on the brain ...
Although acute stress seems to enhance immune function and improve memory,
chronic stress has the opposite effect and may even lead to disorders that
become more prevalent with aging, such as depression, diabetes, and
cognitive impairment"
-
Chronic Stress May Make You Age Faster - WebMD, 8/11/06 -
"Chronic stress -- the type that drags on, rather
than being just a momentary crisis -- can affect hormone levels and shift
the body's delicate hormone balance ... In this way, there may be
synergistic effects of aging and chronic stress"
-
Chronic Stress, Depression and Cortisol Levels Are Potential Risk Indicators
for Periodontal Disease - Doctor's Guide, 5/31/06 -
"being a caregiver to relatives with dementia,
hypercortisolemia (overproduction of cortisol) or stress were associated
with elevated plaque levels and increased gingival bleeding in a study that
examined adults aged 50 years and older"
-
Stress at Work an Important Risk Factor for Development of Heart Disease and
Diabetes - Doctor's Guide, 1/20/06 -
"Researchers examined the association between work
stress and the metabolic syndrome ... men with chronic work stress were
nearly twice as likely to develop the syndrome than those with no exposure
to work stress"
-
Sweet Snacks Could Be Best Medicine For Stress - Science Daily, 11/28/05
-
Cut Stress, Help Your Cholesterol - WebMD, 11/22/05
-
Drug Counters Mental Effect of Stress - WebMD, 11/16/05
-
Women More Sensitive to Stress Than Men? - WebMD, 11/15/05
-
Lost Extra Weight? Stress May Help Gain It Back - WebMD, 10/17/05
- Chronic Stress
Makes Cells Age Faster - WebMD, 11/29/04 -
"In translating telomere length into years of aging,
researchers determined the cells from the highly stressed mothers had aged
from nine to 17 additional years compared with the cells from the low-stress
mothers"
- Stress Linked
to Painful Menstrual Periods - WebMD, 11/17/04
- Commuting
Stress Hurts Heart - WebMD, 9/21/04
-
Levels Of Certain Hormones May Be Increased By Stress - Science Daily,
8/3/04
- Women Snack
More After Stress - WebMD, 5/28/04
- Stress Disrupts
Sleep in More Ways Than One - WebMD, 2/6/04
-
In times like these, depressive disorders are a danger - USA Today,
10/6/03
- Stress Feeds
the Need for Comfort Food - WebMD, 9/9/03
- Job Worries Up
Women's Heart Attack Risk - WebMD, 9/4/03 -
"Many studies have pointed to high blood pressure,
insomnia, anxiety, and depression -- as well as increased levels of the
stress hormone cortisol"
-
Is all that stress killing you? - USAToday.com, 5/26/03
- Highly Educated
Workers More Stressed - WebMD, 4/18/03
-
New Stress-Buster Drugs Block Hormone Binding - Clinical Psychiatry
News, 4/03 -
"A new class of anxiety-relieving drugs—agents that
interrupt core hypothalamic-pituitary-adrenal (HPA) stress signals—will
emerge in the next 2-3 years ... In his HPA axis model of depression, the
affected individual has a blunted ability to counterregulate in response to
stress-induced
cortisol increases, and thus is unable to turn off the fight-or-flight
HPA mechanism. The result is constant anxiety and overreaction to external
stimuli, followed by a sense of learned helplessness and loss of motivation.
Many symptoms of deeply entrenched depression—anxiety,
loss of appetite, reduced libido, elevated heart rate,
hypertension, and dyslipidemia—point to HPA dysregulation ... People
with melancholic depression do tend to produce abnormally high levels of
CRH. These individuals also have elevated levels of cortisol" - See
my
cortisol page for ways to reduce it.
-
High stress before cancer diagnosis may raise risk - USA Today, 3/10/03
-
Can Stress Affect Your Overall Health? - TheSanDiegoChannel.com, 2/20/03
-
Chronic Stress And Metabolic Syndrome Linked - Doctor's Guide, 11/27/02
-
"While the 24-hour
cortisol
metabolite and normetanephrine (three-methoxynorepinephrine) outputs were
higher among cases than controls, HRV and total power were lower among
cases" - Makes sense. Stress increases cortisol, cortisol causes
high blood sugar. Also see my metabolic syndrome
page. - Ben
- Too Much Stress
Hinders Immune System - WebMD, 11/4/02
- Job Stress, Work
Strain Double Risk of Death From Heart Disease - WebMD, 10/17/02
- Financial Stress
of Job Loss Linked to Poor Health - WebMD, 10/8/02
- Exercise, Eating to Enhance
Memory? - Dr. Weil, 9/26/02 -
"Dr. Khalsa explains that in addition to age,
chronic stress can harm the hippocampus via the release of high levels of
the hormone cortisol from the adrenal gland"
- Stress Affects
Men's Health More - WebMD, 9/25/02
- Taking Action Best
for 9/11 Stress - WebMD, 9/10/02
- Putting the Reins
on Stress - WebMD, 9/5/02
-
Practical Stress Management Program Found To Improve Health Of People With
Type 2 Diabetes - Doctor's Guide, 8/26/02
- Mental Stress,
Physical Illness - WebMD, 8/12/02 -
"women who report high levels of mental stress are
twice as likely to die from stroke or heart disease than those with low
stress levels. And stressed-out men may not fare much better" - This
article doesn't get in to it but stress raises
cortisol, which may be responsible for the damage.
- Putting the Reins
on Stress - WebMD, 10/10/01
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