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  • Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta-analysis of randomized controlled trials - Phytother Res 2022 Aug 25 - "Ashwagandha supplementation significantly reduced anxiety (SMD: -1.55, 95% CI: -2.37, -0.74; p = .005; I2 = 93.8%) and stress level (SMD: -1.75; 95% CI: -2.29, -1.22; p = .005; I2 = 83.1%) compared to the placebo. Additionally, the non-linear dose-response analysis indicated a favorable effect of Ashwagandha supplementation on anxiety until 12,000 mg/d and stress at dose of 300-600 mg/d" - See ashwagandha at Amazon.com.
  • Effects of a Bacopa monnieri extract (Bacognize®) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study - J Func Foods, Oct 2021 - "immunoglobulin A (sIgA), α-amylase (sAA) ... Based on the Bergen Insomnia Scale, Bacopa monnieri did not improve sleep patterns more than the placebo; however, it was associated with greater improvements in emotional wellbeing, general health, and pain-related symptoms. Bacopa monnieri was also associated with greater reductions in sIgA and sAA compared to the placebo" - [Nutra USA] - See Bacopa monnieri at Amazon.com and iHerb.
  • Effects of Probiotic NVP-1704 on Mental Health and Sleep in Healthy Adults: An 8-Week Randomized, Double-Blind, Placebo-Controlled Trial - Nutrients 2021, 13(8) - "The human gut microbiome is closely linked to mental health and sleep. We aimed to verify the efficacy and safety of probiotic NVP-1704, a mixture of Lactobacillus reuteri NK33 and Bifidobacterium adolescentis NK98, in improving stress, depression, anxiety, and sleep disturbances, along with the measurement of some blood biomarkers. A total of 156 healthy adults with subclinical symptoms of depression, anxiety, and insomnia were retrospectively registered and randomly assigned to receive either NVP-1704 (n = 78) or a placebo (n = 78) for eight week ... After intervention, gut microbiota composition was quantified by pyrosequencing the bacterial 16S rRNA gene. The NVP-1704 group had a more significant reduction in depressive symptoms at four and eight weeks of treatment, and anxiety symptoms at four weeks compared to the placebo group. Those receiving NVP-1704 also experienced an improvement in sleep quality. NVP-1704 treatment led to a decrease in serum interleukin-6 levels. Furthermore, NVP-1704 increased Bifidobacteriaceae and Lactobacillacea, whereas it decreased Enterobacteriaceae in the gut microbiota composition. Our findings suggest that probiotic NVP-1704 could be beneficial for mental health and sleep" - [Nutra USA] - See probiotic supplements at Amazon.com and iHerb.
  • Therapeutic effects of saffron extract on different memory types, anxiety, and hippocampal BDNF and TNF-α gene expressions in sub-chronically stressed rats - Nutr Neurosci 2021 Jun 24 - "Compared to the low saffron dose, the high dose had a latent but long-lasting impact. Cognitive and spatial memories remained unaffected by either stress or saffron treatment. In addition, only the high saffron dose reversed anxiety in the sub-chronically stressed group. These findings suggest that various doses of saffron act differently on different brain functions under sub-chronic stress condition" - See saffron supplements at Amazon.com.
  • A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers - Nutr Neurosci 2021 Apr 26 - "Green tea and rhodiola have been shown to modulate EEG oscillatory brain activity associated with relaxation and stress perception ... The combined treatment significantly increased EEG resting state theta (p < .02) - considered indicative of a relaxed, alert state, attenuated subjective stress, anxiety and mood disturbance, and heightened subjective and autonomic arousal ... Conclusions: Mg, B vitamins, rhodiola and green tea extracts are a promising combination of ingredients that may enhance coping capacity and offer protection from the negative effects of stress exposure" - See green tea extract at Amazon.com, rhodiola rosea at Amazon.com, Magtein at Amazon.com and B complex supplements at Amazon.com.
  • Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel Group, Clinical Trial - Front Nutr 2021 Feb 1 - "Anxiety, stress, and low mood are closely related and may contribute to depressive symptoms. Among non-pharmacological solutions to improve subclinical mood symptoms and resilience to stress, natural products such as saffron—identified as promising following preliminary beneficial effects in major depressive disorder—represent a relevant strategy. This study aimed to assess the efficacy of 8 weeks' supplementation with 30 mg standardized saffron extract on emotional well-being in healthy adults with subclinical feelings of low mood and anxiety and/or stress and evaluate the acute effect of saffron in response to a lab-based psychosocial stressor. The study adopted a double-blind, randomized, parallel groups design in which 56 healthy male and female individuals (18–54 years) received either a saffron extract or a placebo for 8 weeks ... Participants who received the saffron extract reported reduced depression scores and improved social relationships at the end of the study. Urinary crocetin levels increased significantly with saffron supplementation and were correlated with change in depression scores. The typical stress-induced decrease in heart rate variability (HRV) during exposure to the stressor was attenuated following acute saffron intake. Saffron extract appears to improve subclinical depressive symptoms in healthy individuals and may contribute to increased resilience against the development of stress-related psychiatric disorders." - [Nutra USA] - See saffron supplements at Amazon.com.
  • Lacticaseibacillus paracasei Lpc-37® improves psychological and physiological markers of stress and anxiety in healthy adults: a randomized, double-blind, placebo-controlled and parallel clinical trial (the Sisu study) - Neurobiol Stress. 2020 Nov 24 - "Chronic stress is a risk-factor for the development of mood and stress-related disorders. Clinical evidence indicates that probiotics can influence the stress response and mood. The Sisu study investigated whether Lacticaseibacillus paracasei Lpc-37® (Lpc-37®) could modulate stress, mood and well-being. Prior to a two-week run-in period, 120 healthy adults (18-45 y) were stratified for sex and chronic stress and randomized to either 1.75 × 1010 colony forming units (CFU) of Lpc-37 or placebo (1:1) per day for 5 weeks. The primary objective was the effect of Lpc-37 on heart rate (HR) in response to the Trier Social Stress Test (TSST). Secondary objectives were assessed by biomarkers and self-report scales over the study. The primary hypothesis was not met in either the Intention-to-Treat (ITT) or Per Protocol (PP) population, but Lpc-37 reduced the increase in HR in participants with low chronic stress (LCS) and increased HR in participants with high chronic stress (HCS) during the TSST. Supporting significant efficacy in the PP population (n = 113), Lpc-37 reduced perceived stress following intervention. More significant effects were identified within the subgroups where Lpc-37 reduced exhaustion during the TSST and normalized cortisol levels at 8pm in participants with LCS, reduced perceived stress also in females, and increased perceived health and sleep-related recovery in participants with HCS. Adverse events (AEs) were similar between groups, there were no severe AEs, and vital signs remained unchanged" - [Nutra USA] - See probiotic supplements at Amazon.com.
  • Lactobacillus plantarum DR7 alleviates stress and anxiety in adults: a randomised, double-blind, placebo-controlled study - Benef Microbes. 2019 Apr 19 - "One hundred and eleven (n=111; DR7 n=56, placebo n=55) stressed adults were recruited based on moderate stress levels using the PSS-10 questionnaire. The consumption of DR7 (1×109 cfu/day) for 12 weeks reduced symptoms of stress (P=0.024), anxiety (P=0.001), and total psychological scores (P=0.022) as early as 8 weeks among stressed adults compared to the placebo group as assessed by the DASS-42 questionnaire. Plasma cortisol level was reduced among DR7 subjects as compared to the placebo, accompanied by reduced plasma pro-inflammatory cytokines, such as interferon-γ and transforming growth factor-α and increased plasma anti-inflammatory cytokines, such as interleukin 10 (P<0.05). DR7 better improved cognitive and memory functions in normal adults (>30 years old), such as basic attention, emotional cognition, and associate learning (P<0.05), as compared to the placebo and young adults (<30 years old). The administration of DR7 enhanced the serotonin pathway, as observed by lowered expressions of plasma dopamine β-hydroxylase (DBH), tyrosine hydroxylase (TH), indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase accompanied by increased expressions of tryptophan hydroxylase-2 and 5-hydroxytryptamine receptor-6, while stabilising the dopamine pathway as observed via stabilised expressions of TH and DBH over 12 weeks as compared to the placebo" - [Nutra USA] - See probiotic products at Amazon.com.
  • Efficacy and safety of Eurycoma longifolia (Physta®) water extract plus multivitamins on quality of life, mood and stress: a randomized placebo-controlled and parallel study - Food and Nutri, 10/18 - "While there were no significant between-group differences, within-group improvements were observed in the SF-12 QoL, POMS and MMSQ domains. In the SF-12 domain, improvements were seen in role limitation due to emotional health (P = 0.05), mental component domain (P < 0.001), emotional well-being (P < 0.001), social functioning (P = 0.002) as well as vitality (P = 0.001) at week 12. An increasing trend in POMS-vigour domain was also observed in the EL+MV group at week 12. A 15% decrease in physical stress domain (P < 0.05) compared with 0.7% in the placebo group was also observed in MMSQ" - [Nutra USA] - See Physta at Amazon.com.
  • Supplementation with Robuvit® in subjects with burnout associated to high oxidative stress - Minerva Med. 2018 Jun;109(3):211-217 - "This supplement registry study evaluated the effect of supplementation with Robuvit® on the burnout syndrome (BOS) of patients with significant fatigue and high oxidative stress. Robuvit® (French oak wood extract) is a standardized supplement, effective in treating chronic fatigue syndrome (CFS), post-traumatic stress disorder (PTSD) and convalescence ... Subjects followed a standard management (SM); one half of the subjects received 300 mg/day of Robuvit® for 4 weeks in addition to SM ... Robuvit® by controlling fatigue (the primary symptom) and oxidative stress, relieves the most important 'symptoms' associated with BOS. The effects are comparable in young surgeons not accustomed to stress, as well as in professionals in management positions who are used to control stress" - [Nutra USA] - See Robuvit® at Amazon.com.
  • Memory enhancement of fresh ginseng on deficits induced by chronic restraint stress in mice - Nutr Neurosci. 2017 Sep 15:1-8 - "Chronic stress exposure can disrupt the balance of organisms, result in learning and memory impairments and induce oxidative stress ... Fresh ginseng (FG), an unprocessed raw root of ginseng, has antioxidant and neuroprotective activities and has been used as functional health food in Asian countries for many years ... Our results suggest that FG treatment could improve CRS-induced learning and memory impairments and oxidative stress damage. FG is an intriguing therapeutic agent and functional health food in stress-related dementia"
  • Cannot sleep due to stress? Here is the cure - Science Daily, 9/5/17 - "Octacosanol reduced corticosterone level in blood plasma, which is a stress marker. The octacosanol-administered mice also showed normal sleep, which was previously disturbed due to stress. They therefore claim that the octacosanol mitigates stress in mice and restores stress-affected sleep to normal in mice. The sleep induced by octacosanol was similar to natural sleep and physiological in nature. However, authors also claimed that octacosanol does not affect sleep in normal animals. These results clearly demonstrated that octacosanol is an active compound that has potential to reduce stress and to increase sleep, and it could potentially be useful for the therapy of insomnia caused by stress" - See policosanol at Amazon.com.
  • Supplementation with macular carotenoids reduces psychological stress, serum cortisol, and sub-optimal symptoms of physical and emotional health in young adults - Nutr Neurosci. 2017 Feb 15:1-11 - "Oxidative stress and systemic inflammation are the root cause of several deleterious effects of chronic psychological stress. We hypothesize that the antioxidant and anti-inflammatory capabilities of the macular carotenoids (MCs) lutein, zeaxanthin, and meso-zeaxanthin could, via daily supplementation, provide a dietary means of benefit ... Supplementation with the MCs significantly reduces stress, cortisol, and symptoms of sub-optimal emotional and physical health" - See carotenoids supplement at Amazon.com.
  • Common probiotics can reduce stress levels, lessen anxiety - Science Daily, 11/21/16 - "a common probiotic sold in supplements and yogurt can decrease stress-related behavior and anxiety ... bacteria in the gut altered the gene expression associated with stress- and anxiety-related pathways in the fish allowing for increased signaling of particular neurotransmitters" - See probiotic products at Amazon.com.
  • Early supplementation may help offset early-life stress on the adult brain - Science Daily, 10/26/16 - "Specifically, using mice, scientists focused on essential micronutrients, including methionine, vitamins B6and B12, and folic acid, none of which are made by the body and need to be ingested through diet. They found that early-life stress reduces the levels of these nutrients in mouse pups, but supplementation prevented the reduction of methionine levels and even prevented some of the lasting negative effects of early-life stress on later learning and memory in adult offspring ... Here we see strikingly beneficial cognitive effects of a sound postnatal diet. The nutrients tested were familiar ones, but the results speak for themselves"
  • Early micronutrient supplementation protects against early stress-induced cognitive impairments - FASEB J. 2016 Oct 21 - "Early-life stress (ES) impairs cognition later in life. Because ES prevention is problematic, intervention is needed, yet the mechanisms that underlie ES remain largely unknown ... In conclusion, nutrition is important in brain programming by ES. A short, early supplementation with essential micronutrients can already prevent lasting effects of ES"
  • Safety, Tolerance, and Enhanced Efficacy of a Bioavailable Formulation of Curcumin With Fenugreek Dietary Fiber on Occupational Stress: A Randomized, Double-Blind, Placebo-Controlled Pilot Study - J Clin Psychopharmacol. 2016 Apr 2 - "CurQfen (curcumagalactomannoside [CGM]), a food-grade formulation of natural curcumin with fenugreek dietary fiber that has shown to possess improved blood-brain-barrier permeability and tissue distribution in rats. In this randomized double-blinded and placebo-controlled trial, 60 subjects experiencing occupational stress-related anxiety and fatigue were randomized to receive CGM, standard curcumin, and placebo for 30 days (500 mg twice daily). The study demonstrated the safety, tolerance, and enhanced efficacy of CGM in comparison with unformulated standard curcumin. A significant improvement in the quality of life (P < 0.05) with considerable reduction in stress (P < 0.001), anxiety (P < 0.001), and fatigue (P < 0.001) was observed among CGM-treated subjects as compared with the standard curcumin group, when monitored by SF-36, Perceived Stress Scale with 14 items, and Beck Anxiety Inventory scores. Improvement in the quality of life was further correlated with the significant enhancement in endogenous antioxidant markers (P < 0.01) and reduction in lipid peroxidation (P < 0.001). Further comparison of the free curcuminoids bioavailability after a single-dose (500 mg once per day) and repeated-dose (500 mg twice daily for 30 days) oral administration revealed enhanced absorption and improved pharmacokinetics of CGM upon both single- (30.7-fold) and repeated-dose (39.1-fold) administrations" - [Nutra USA] - See CurQfen at Amazon.com.
  • The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms - Phytother Res. 2015 Oct 27 - "Rhodiola rosea L (2 × 200 mg dose Vitano®, 1 tablet taken before breakfast and 1tablet before lunch) or a control condition (no treatment) ... Relative to the controls, the experimental group demonstrated a significant reduction in self-reported, anxiety, stress, anger, confusion and depression at 14 days and a significant improvements in total mood" - See Rhodiola rosea at Amazon.com.
  • Nutrient Supplements Ease Anxiety, Stress Due to Disasters - Medscape, 7/15/15 - "Seventeen participants were randomly assigned to receive vitamin D supplementation (1000 IU in one capsule daily); 21 were assigned to a regimen with "few nutrients" consisting of a vitamin B–complex supplement containing B6, B12, thiamine, riboflavin, folate, d-pantothenic acid, intrinsic factor, biotin, and niacin (one capsule daily); and 18 received a broad-spectrum mineral and vitamin (BSMV) formula (four capsules daily). Overall compliance with the nutrient supplements during the 6-week study period was high in all three groups (roughly 93%) ... throughout the 6 weeks, all groups showed substantial decreases on all measures, but those taking the B-complex or the BSMV formulas showed significantly greater improvement in stress and anxiety levels relative to those taking only vitamin D, with "large" effect sizes (Cohen's d range, 0.76 - 1.08)"
  • Acute mood but not cognitive improvements following administration of a single multivitamin and mineral supplement in healthy women aged 50 and above: a randomised controlled trial - Age (Dordr). 2015 Jun;37(3):9782 - "This study investigated the acute effects of a single multivitamin and mineral and herbal (MVMH) supplement versus placebo on self ratings of mood and the performance of an effortful computerised cognitive battery in a sample of 76 healthy women aged 50-75 years. Mood was assessed using the depression anxiety stress scale (DASS), state trait anxiety inventory-state anxiety scale and visual analogue scales (VAS). Mood was rated at 1 h post supplementation and again after the competition of the cognitive assessments at 2 h post supplementation. It was demonstrated that the MVMH supplement improved overall DASS mood ratings; however, the most prominent effects appeared to be a reduction in ratings of perceived mental stress ... Supplementation with a single multivitamin, mineral and herbal supplement reduces stress several hours after intake in healthy older people"
  • Want a better work-life balance? Exercise, study finds - Science Daily, 1/9/14 - "Individuals who exercised regularly were more confident they could handle the interaction of their work and home life and were less likely to be stressed at work ... The idea sounds counterintuitive. How is it that adding something else to our work day helps to alleviate stress and empower us to deal with work-family issues? We think exercise is a way to psychologically detach from work -- you're not there physically and you're not thinking about it either -- and, furthermore, it can help us feel good about ourselves ... Researchers examined responses of 476 working adults to survey questions ... Our findings suggest that employers can help employees with work-life balance by encouraging them to exercise"
  • Effect of Magnolia officinalis and Phellodendron amurense (Relora(R)) on cortisol and psychological mood state in moderately stressed subjects - J Int Soc Sports Nutr. 2013 Aug 7;10(1):37 - "Magnolia (Magnolia officinalis) and Phellodendron (Phellodendron amurense) barks are medicinal plants commonly used as traditional remedies for reducing stress and anxiety ... assessed salivary cortisol exposure and psychological mood state in 56 subjects (35 men and 21 women) screened for moderate stress and supplemented with a standardized/patented MP combination (Relora(R), Next Pharmaceuticals) or Placebo for 4 weeks ... After 4 weeks of supplementation, salivary cortisol exposure was significantly (p<0.05) lower (-18%) in the Relora group compared to Placebo. Compared to Placebo, the Relora group had significantly better (p<0.05) mood state parameters, including lower indices of Overall Stress (-11%), Tension (-13%), Depression (-20%), Anger (-42%), Fatigue (-31%), and Confusion (-27%), and higher indices of Global Mood State (+11%) and Vigor (+18%)" - Note: The biggest affect was on anger (-42%).  - See Relora at Amazon.com.
  • Fish oil may help the heart beat mental stress - Science Daily, 5/22/13 - "volunteers who took fish oil supplements for several weeks had a blunted response to mental stress in several measurements of cardiovascular health, including heart rate and muscle sympathetic nerve activity (MSNA), part of the "fight or flight" response, compared to volunteers who took olive oil instead. The results may explain why taking fish oil could be beneficial to the heart and might eventually help doctors prevent heart disease in select populations" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Probiotics reduce stress-induced intestinal flare-ups, study finds - Science Daily, 3/14/13 - "while stress does not cause IBS, it does alter brain-gut interactions and induces the intestinal inflammation that often leads to severe or chronic belly pain, loss of appetite and diarrhea ... Stress has a way of suppressing an important component called an inflammasome which is needed to maintain normal gut microbiota, but probiotics reversed the effect in animal models ... The effect of stress could be protected with probiotics which reversed the inhibition of the inflammasome" - See probiotic products at Amazon.com.
  • Antioxidant Ingredient Proven To Relieve Stress - Science Daily, 9/14/09 - "The 35 people in our study who received capsules containing superoxide dismutase showed improvement in several signs and symptoms of perceived stress and fatigue" - See SOD supplements at Amazon.com.
  • Best stress relievers - MSNBC, 2/5/06
  • Stress-Busting Help Comes From Hormone - WebMD, 8/2/04 - "The people who reported fewer symptoms and who performed best at their military tasks had "significantly higher" levels of the hormone DHEA-S compared with cortisol" [Abstract] - See DHEA at Amazon.com.
  • Stress, Cortisol and Health - Supplement Watch Newsletter, 10/02 - "several lines of evidence have converged to solidify the concept that stress makes us fat (because of cortisol), thins our bones (because of cortisol), shrinks our brains (because of cortisol), suppresses our immune system (because of cortisol), saps our energy levels (because of cortisol), and kills our sex drive (because of cortisol) ... Take a daily multivitamin/multi-mineral supplement - because calcium, magnesium, vitamin C and B-complex vitamins are needed for a proper stress response ... Chief among the supplements with documented cortisol-controlling effects are Phosphatidylserine, Beta-sitosterol, Magnolia bark, Theanine, Epimedium, Ashwagandha and Passionflower"
  • Putting the Reins on Stress - WebMD, 9/5/02
  • Stress: The Hidden Factor For Weight Gain - Natural Foods Merchandiser, 4/02
  • The Ultimate Relaxant - Life Extension Magazine, 1/02 - "Theanine is an amino acid found in green tea. It helps to produce a calming effect in the brain and induces a feeling of relaxation and well-being. Best of all, it does all of this without causing drowsiness. In fact, studies have shown that theanine enhances the ability to learn and remember. One of the other benefits of this amino acid is that it helps to lower blood pressure naturally, by enhancing GABA in the brain"
  • Stress: The Hidden Factor For Weight Gain - Nutrition Science News, 4/01

Other News:

  • Stress May Turn Hair Gray, but Calm May Reverse It - Medscape, 7/8/21 - "They developed a mathematical model to predict what might happen to human hair over time and suggest there is a point in a person's life when stress can temporarily induce loss of color, but that can be reversed if tensions ease"
  • Stressful jobs are associated with a higher risk of heart rhythm disorders - Science Daily, 6/4/18 - "The study found that being stressed at work was associated with a 48% higher risk of atrial fibrillation, after adjustment for age, sex, and education"
  • Stress Can Make the Pounds Accumulate - NYT, 3/1/17 - "After controlling for age, sex, ethnicity, smoking, diabetes and other factors that might be linked to obesity, they found that the higher the level of cortisol, the greater the body weight, B.M.I. and waist circumference. Higher cortisol levels were also associated with persistence of obesity over time"
  • Why being tired makes us look ugly - nbcnews.com, 12/19/12 - "Stress causes a drop in the skin’s ability to protect itself ... And stress can also lead to less melanin, causing that jaundiced, haggard look. Melanin pigments the skin, giving humans their complexion ... Not sleeping causes us to accumulate water under our eyes, giving us that extra "baggage" ... What you get from stress is the wrinkles of aging .. Stress causes you to age ... stress not only causes wrinkles on the face but wrinkles in your arteries, as well, which can cause serious problems at an earlier age ... Your cells are biologically 10 to 15 years older … if you are chronically stressed ... If you are 45, the cells signal as if they are 60 years old"
  • Does depression contribute to the aging process? - Science Daily, 2/21/12 - "telomere length was shorter in the depressed patients, which confirmed prior findings. Importantly, they also discovered that shorter telomere length was associated with a low cortisol state in both the depressed and healthy groups ... stress plays an important role in depression, as telomere length was especially shortened in patients exhibiting an overly sensitive HPA axis. This HPA axis response is something which has been linked to chronic stress and with poor ability to cope with stress" - Note:  I'm not sure if that's correct because depressed people usually have high cortisol, not low cortisol.  I read somewhere that PTSD was associated with low cortisol.
  • Anticipation of stressful situations accelerates cellular aging - Science Daily, 2/21/12 - "The researchers assessed cellular age by measuring telomeres, which are the protective caps on the ends of chromosomes. Short telomeres index older cellular age and are associated with increased risk for a host of chronic diseases of aging, including cancer, heart disease and stroke ... higher levels of anticipated threat in daily life may promote cellular aging in chronically stressed individuals"
  • Depression and chronic stress accelerates aging - Science Daily, 11/9/11 - "The telomere is the outermost part of the chromosome. With increasing age, telomeres shorten, and studies have shown that oxidative stress and inflammation accelerates this shortening. On this basis it has been suggested that telomere length is a measure of biological aging, and telomere length has subsequently been linked to age-related diseases, unhealthy lifestyle, and longevity. The research team shows that shorter telomere length is associated with both recurrent depression and cortisol levels indicative of exposure to chronic stress"
  • At last, a reason why stress causes DNA damage - Science Daily, 8/21/11
  • Stress can affect future offspring - Science Daily, 8/16/11
  • Stress may increase risk for Alzheimer's disease - Science Daily, 5/26/11 - "Fewer than ten percent of Alzheimer cases have a genetic basis. The factors that contribute to the rest of the cases are largely unknown ... life events (stress) may be one trigger ... stress, and the hormones released during stress, can accelerate the development of Alzheimer disease-like biochemical and behavioural pathology"
  • Social isolation, stress-induced obesity increases breast cancer risk in mice - Science Daily, 4/4/11 - "Stress from social isolation, combined with a high-fat diet, increases levels of a brain neurotransmitter -- neuropeptide Y, or NPY -- in mice that then promotes obesity, insulin resistance, and breast cancer risk ... To conduct the study, the researchers used female mice that develop breast cancer when given progesterone and a carcinogen. They established four groups of these mice: one group that lived together (not socially isolated) and ate a normal diet; a group that was isolated (each alone in a cage) and ate normally; an isolated group that ate a high-fat diet, and a group that lived together and ate a high-fat diet ... Ten weeks after treatment and living in these environments (for a total of 17 weeks), 92 percent of the socially-isolated mice fed a high-fat diet had developed tumors, compared to 36 percent of socially-isolated mice fed a normal diet and 36 percent of grouped mice that were also fed normally. But 67 percent of mice who were happy in group homes, but were fed a high fat diet, developed breast cancer"
  • Even mild stress is linked to long-term disability, study finds - Science Daily, 3/23/11 - "Between 2002 and 2007, the authors tracked the health of more than 17,000 working adults up to the age of 64, who had been randomly selected from the population in the Stockholm area ... Higher levels of stress at the start of the study were associated with a significantly greater likelihood of subsequently being awarded long term disability benefits ... But even those with mild stress were up to 70% more likely to receive disability benefits ... One in four of these benefits awarded for a physical illness, such as high blood pressure, angina, and stroke, and almost two thirds awarded for a mental illness, were attributable to stress"
  • Simple spit and blood tests might detect burnout before it happens - Science Daily, 2/21/11 - "In addition to professional and personal suffering, burnout puts distressed workers at further risk of physical and psychological problems if ignored ... We hypothesized that healthy workers with chronic stress and with mild burnout symptoms would have worse physiological dysregulations and lower cortisol levels -- a profile consistent with burnout ... Cortisol is a stress hormone involved in our bodies stress response and naturally as part of our body's daily rhythm. Cortisol levels are often high in people suffering from depression, while it tends to be low in cases of burnout. Too much cortisol can be as bad as too little when it comes to both mental and physical health ... Critically, people with burnout are often treated with anti-depressant medications that lower cortisol levels. If cortisol is already lower than it should be, this course of treatment could represent a therapeutic mistake. "The use of an allostatic load index gives researchers and clinicians a window to see how chronic stress is straining the person"
  • Casualties of war: Wounded veterans more likely to die of coronary heart disease - Science Daily, 1/26/11 - "During the 28 year follow up , out of 412 deaths, 140 were due to coronary heart disease (CHD), making wounded veterans 1.7 times more likely to die from CHD than the comparison group ... those who had been wounded in action had a higher BMI, a greater history of self-reported depression and were more likely to be claiming disability pension. This also suggests that as well as increased risk of PTSD, physical trauma in early life may cause longstanding physiological implications"
  • Social stress leads to atherosclerosis, research suggests - Science Daily, 12/6/10
  • Stress accelerates breast cancer progression in mice, researchers find - Science Daily, 9/15/10 - "stress is biologically reprogramming the immune cells that are trying to fight the cancer, transforming them instead from soldiers protecting the body against disease into aiders and abettors. The study found a 30-fold increase in cancer spread throughout the bodies of stressed mice compared to those that were not stressed ... Beta blockers, used in this study to shut down the stress pathways in the mice, are currently being examined in several large breast cancer databases for their role in potential prevention of recurrence and cancer spread ... using beta blockers in stressed mice prevented the same cancer progression seen in the stressed mice that did not receive medication"
  • Hair provides proof of the link between chronic stress and heart attack - Science Daily, 9/3/10 - "Cortisol is considered to be a stress hormone. Its secretion is increased during times of stress. Traditionally it's been measured in serum, urine and saliva, but that only shows stress at the time of measurement, not over longer periods of time. Cortisol is also captured in the hair shaft"
  • Seeing family for the holidays? Scientists discover how the stress might kill you - Science Daily, 11/30/09
  • Prolonged Stress Sparks Endoplasmic Reticulum To Release Calcium Stores And Induce Cell Death In Aging-related Diseases - Science Daily, 9/27/09
  • Stress Raises Belly Fat, Heart Risks - WebMD, 8/6/09 - "Even compared to other monkeys with the same body mass index and weight, CT scans showed that the stressed monkeys had a great deal more belly fat. And when the researchers looked at the animals' arteries, they found plaque clogging the arteries of the stressed monkeys ... it's not how much fat you have, but where it is located ... Over time, high cortisol levels cause belly fat to accumulate. It also makes individual fat cells get larger ... When you have lots more fat in visceral fat cells and all the characteristics of the metabolic syndrome, each of these things promotes atherosclerosis"
  • Life's Stress May Lead to Weight Gain - WebMD, 7/8/09
  • Stress Makes Your Hair Go Gray - Science Daily, 6/11/09 - "Those pesky graying hairs that tend to crop up with age really are signs of stress, reveals a new report in the journal Cell"
  • Symptoms Of Depression Associated With Increase In Abdominal Fat - Science Daily, 12/1/08 - "There are several mechanisms by which depression might increase abdominal fat, they note. Chronic stress and depression may activate certain brain areas and lead to increased levels of the hormone cortisol, which promotes the accumulation of visceral fat. Individuals with depression may have unhealthier lifestyles, including a poor diet, that could interact with other physiological factors to produce an increase in abdominal obesity" - See my cortisol page for ways to reduce it.  Cortisol is like the chicken and the egg with depression.  They don't seem to know whether it is the cause or result.
  • Psychological Distress May Increase Risk of Breast Cancer - Medscape, 9/15/08 - "The team evaluated interactions between breast cancer and severe life events -- such as loss of a parent or divorce of parents before age 20, or loss of a close relative or spouse -- and mild to moderate life events -- e.g., separation from a spouse, loss of a job, an economic crisis, or severe illness in a close relative ... Multivariate analysis revealed a positive association (odds ratio, 1.62) between exposure to more than one adverse life event and breast cancer. "It wasn't enough to be exposed to one life event, a woman had to be exposed to more than one event,""
  • Neurogenesis In Adult Brain: Association With Stress And Depression - Science Daily, 8/31/08 - "Chronic stress can affect the brain and lead into depression"
  • Stress Hormone Found To Regulate Brain Neurotransmission - Science Daily, 8/7/08 - "When we are subjected to a stress, our adrenal glands secrete hormones that affect our entire body. One of these hormones, cortisol, enables us to adapt physically and mentally to the stimulus. Following a major or repeated stress that the individual has no control over, however, cortisol is secreted in great quantities over a long period of time. This hypersecretion has damaging effects on the individual, to the point of accelerating aging and facilitating the onset of illnesses such as depression"
  • Stress May Increase A Woman's Risk Of Developing Cervical Cancer - Science Daily, 2/15/08
  • Stress At Work Is Linked To Heart Disease - Science Daily, 1/22/08 - "chronic work stress was associated with CHD and this association was stronger among both men and women aged under 50 -- their risk of CHD was an average of 68% more than for people who reported no stress at work"
  • Sept. 11 Stress Increases Risk Of Heart Problems, Study Suggests - Science Daily, 1/7/08 - "Our study is the first to show that even among people who had no personal connection to the victims, those who reported high levels of post-traumatic stress symptoms in the days following the 9/11 attacks were more than twice as likely to report being diagnosed by their doctors with cardiovascular ailments like high blood pressure, heart problems and stroke up to three years later"
  • Depression Associated With Low Bone Mineral Density - Medscape, 12/3/07 - "The novelty of this study is the fact that these women were not severely depressed ... Depression is considered a disease of chronic stress, Dr. Cizza said, with attendant increases in the stress hormone cortisol, and cytokines produced by the immune system. "Those substances are helpful to fight stress, but if there is too much cortisol or cytokines, there are side effects," he said. "One of the side effects is bone loss, so it was obvious to ask the question, 'do women with depression have low bone mass?'""
  • Stress Hormone May Hasten The Progression Of Certain Blood Cancers - Science Daily, 11/19/07
  • Feeling Stressed? How Your Skin, Hair And Nails Can Show It - Science Daily, 11/12/07 - "When a person becomes stressed, the level of the body’s stress hormone (cortisol) rises. This in turn causes an increase in oil production, which can lead to oily skin, acne and other related skin problems ... stress has a negative effect on the barrier function of the skin, resulting in water loss that inhibits the skin’s ability to repair itself after an injury"
  • Psychological Stress May Mar Skin WebMD, 11/1/07
  • How Stress Harms the Heart - Time, 10/9/07
  • Stress Contributes To Range Of Chronic Diseases, Review Shows - Science Daily, 10/9/07
  • High Hostility Linked with Poor Ability to Cope With Stress, Low HDL Levels - Medscape, 8/30/07 - "individuals who were very hostile were more likely to perceive problems as stressful and to cope with stress by using interpersonal hostility, self-blame, and social isolation; they also tended to have lower levels of HDL"
  • New Alzheimer's findings: High stress and genetic risk factor lead to increased memory decline - Doctor's Guide, 8/27/07 - "High stress levels may contribute to memory loss among people at risk for developing Alzheimer's disease"
  • Coping With Stress Helps Cholesterol - WebMD, 8/20/07 - "People who coped well had higher levels of HDL than people who didn't cope well ... The amount of stress you deal with isn't as important, they also found, as how you deal with it. "Stress doesn't matter nearly as much as how you cope with it,""
  • Stress May Wreak Havoc on Your Mouth - WebMD, 8/13/07
  • Job Stress Jacks Up Blood Pressure - WebMD, 4/10/07 - "Their blood pressure was highest on the job, when they had 5.9/3.0 mm Hg higher blood pressure than the nonstressed workers did. But the stressed-out workers also had higher blood pressure while at home, including while they were sleeping"
  • Stress May Help Cancer Cells Stay Alive - Doctor's Guide, 4/10/07 - "the stress hormone epinephrine causes changes in prostate and breast cancer cells that may make them resistant to cell death"
  • Reactions to Stress May Affect Brain Aging - Medscape, 8/14/06 - "the adrenal stress hormone cortisol appears to play an important role in mediating the effects of stress on the brain ... Although acute stress seems to enhance immune function and improve memory, chronic stress has the opposite effect and may even lead to disorders that become more prevalent with aging, such as depression, diabetes, and cognitive impairment"
  • Chronic Stress May Make You Age Faster - WebMD, 8/11/06 - "Chronic stress -- the type that drags on, rather than being just a momentary crisis -- can affect hormone levels and shift the body's delicate hormone balance ... In this way, there may be synergistic effects of aging and chronic stress"
  • Chronic Stress, Depression and Cortisol Levels Are Potential Risk Indicators for Periodontal Disease - Doctor's Guide, 5/31/06 - "being a caregiver to relatives with dementia, hypercortisolemia (overproduction of cortisol) or stress were associated with elevated plaque levels and increased gingival bleeding in a study that examined adults aged 50 years and older"
  • Stress at Work an Important Risk Factor for Development of Heart Disease and Diabetes - Doctor's Guide, 1/20/06 - "Researchers examined the association between work stress and the metabolic syndrome ... men with chronic work stress were nearly twice as likely to develop the syndrome than those with no exposure to work stress"
  • Sweet Snacks Could Be Best Medicine For Stress - Science Daily, 11/28/05
  • Cut Stress, Help Your Cholesterol - WebMD, 11/22/05
  • Drug Counters Mental Effect of Stress - WebMD, 11/16/05
  • Women More Sensitive to Stress Than Men? - WebMD, 11/15/05
  • Lost Extra Weight? Stress May Help Gain It Back - WebMD, 10/17/05
  • Chronic Stress Makes Cells Age Faster - WebMD, 11/29/04 - "In translating telomere length into years of aging, researchers determined the cells from the highly stressed mothers had aged from nine to 17 additional years compared with the cells from the low-stress mothers"
  • Stress Linked to Painful Menstrual Periods - WebMD, 11/17/04
  • Commuting Stress Hurts Heart - WebMD, 9/21/04
  • Levels Of Certain Hormones May Be Increased By Stress - Science Daily, 8/3/04
  • Women Snack More After Stress - WebMD, 5/28/04
  • Stress Disrupts Sleep in More Ways Than One - WebMD, 2/6/04
  • In times like these, depressive disorders are a danger - USA Today, 10/6/03
  • Stress Feeds the Need for Comfort Food - WebMD, 9/9/03
  • Job Worries Up Women's Heart Attack Risk - WebMD, 9/4/03 - "Many studies have pointed to high blood pressure, insomnia, anxiety, and depression -- as well as increased levels of the stress hormone cortisol"
  • Is all that stress killing you? - USAToday.com, 5/26/03
  • Highly Educated Workers More Stressed - WebMD, 4/18/03
  • New Stress-Buster Drugs Block Hormone Binding - Clinical Psychiatry News, 4/03 - "A new class of anxiety-relieving drugs—agents that interrupt core hypothalamic-pituitary-adrenal (HPA) stress signals—will emerge in the next 2-3 years ... In his HPA axis model of depression, the affected individual has a blunted ability to counterregulate in response to stress-induced cortisol increases, and thus is unable to turn off the fight-or-flight HPA mechanism. The result is constant anxiety and overreaction to external stimuli, followed by a sense of learned helplessness and loss of motivation. Many symptoms of deeply entrenched depressionanxiety, loss of appetite, reduced libido, elevated heart rate, hypertension, and dyslipidemia—point to HPA dysregulation ... People with melancholic depression do tend to produce abnormally high levels of CRH. These individuals also have elevated levels of cortisol" - See my cortisol page for ways to reduce it.
  • High stress before cancer diagnosis may raise risk - USA Today, 3/10/03
  • Can Stress Affect Your Overall Health? - TheSanDiegoChannel.com, 2/20/03
  • Chronic Stress And Metabolic Syndrome Linked - Doctor's Guide, 11/27/02 - "While the 24-hour cortisol metabolite and normetanephrine (three-methoxynorepinephrine) outputs were higher among cases than controls, HRV and total power were lower among cases" - Makes sense.  Stress increases cortisol, cortisol causes high blood sugar.  Also see my metabolic syndrome page. - Ben
  • Too Much Stress Hinders Immune System - WebMD, 11/4/02
  • Job Stress, Work Strain Double Risk of Death From Heart Disease - WebMD, 10/17/02
  • Financial Stress of Job Loss Linked to Poor Health - WebMD, 10/8/02
  • Exercise, Eating to Enhance Memory? - Dr. Weil, 9/26/02 - "Dr. Khalsa explains that in addition to age, chronic stress can harm the hippocampus via the release of high levels of the hormone cortisol from the adrenal gland"
  • Stress Affects Men's Health More - WebMD, 9/25/02
  • Taking Action Best for 9/11 Stress - WebMD, 9/10/02
  • Putting the Reins on Stress - WebMD, 9/5/02
  • Practical Stress Management Program Found To Improve Health Of People With Type 2 Diabetes - Doctor's Guide, 8/26/02
  • Mental Stress, Physical Illness - WebMD, 8/12/02 - "women who report high levels of mental stress are twice as likely to die from stroke or heart disease than those with low stress levels. And stressed-out men may not fare much better" - This article doesn't get in to it but stress raises cortisol, which may be responsible for the damage.
  • Putting the Reins on Stress - WebMD, 10/10/01