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Rapamycin

Where to purchase:

• Siromus at ReliableRXPharmacy

Sirolimus - Wikipedia - "Sirolimus (INN/USAN), also known as rapamycin, is a macrolide produced by the bacteria Streptomyces hygroscopicus. It has immunosuppressant functions in humans and is used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It prevents activation of T cells and B cells by inhibiting their response to interleukin-2 (IL-2)"

News & Research:

• Muscle aging: Stronger for longer - Science Daily, 9/9/20 - "Contrary to our expectations, the long-term mTORC1 suppression with rapamycin is overwhelmingly beneficial for skeletal muscle aging in mice, preserving muscle size and strength ... There is currently no effective pharmacological therapy to treat sarcopenia. This study provides hope that it may be possible to slow down age-related muscle wasting with treatments that suppress mTORC1 and thereby extend the autonomy and life quality of elderly people" - See Siromus at ReliableRXPharmacy.
• Immune-regulating drug improves gum disease in mice - Science Daily, 4/28/20 - "Rapamycin is an immune-suppressing drug currently used to prevent organ rejection in transplant recipients. Previous studies in mice have also suggested that it may have life-extending effects, which has led to interest in studying the drug's effects in many age-related diseases ... added the drug to the food of middle-aged mice for eight weeks and compared their oral health with untreated mice of the same age ... the treated mice had more bone than the untreated mice, and had actually grown new bone during the period they were receiving rapamycin ... The work also showed that rapamycin-treated mice had less gum inflammation. Genetic sequencing of the bacteria in their mouths also revealed that the animals had fewer bacteria associated with gum disease and a mix of oral bacteria more similar to that found in healthy young mice ... By targeting this aging process through rapamycin treatment, our work suggests that we can delay the progress of gum disease and actually reverse its clinical features ... while rapamycin is already used to treat certain conditions, it can make people more susceptible to infections and may increase their risk of developing diabetes, at least at the higher chronic doses typically taken by organ transplant patients"
  • Sirolimus - wiki - "Sirolimus, also known as rapamycin, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection and treat a rare lung disease called lymphangioleiomyomatosis.[4][5][6] It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants"
• Rapamycin may slow skin aging - Science Daily, 11/25/19 - "In the current Drexel-led study, 13 participants over age 40 applied rapamycin cream every 1-2 days to one hand and a placebo to the other hand for eight months. The researchers checked on subjects after two, four, six and eight months, including conducting a blood test and a biopsy at the six- or eight-month mark ... After eight months, the majority of the rapamycin hands showed increases in collagen protein, and statistically significant lower levels of p16 protein, a key marker of skin cell aging. Skin that has lower levels of p16 has fewer senescent cells, which are associated with skin wrinkles. Beyond cosmetic effects, higher levels of p16 can lead to dermal atrophy, a common condition in seniors, which is associated with fragile skin that tears easily, slow healing after cuts and increased risk of infection or complications after an injury"
• Rapamycin prevents age-related brain vascular deterioration in rats - Science Daily, 11/6/19 - "In the study, published Nov. 6 in the journal Aging Cell, researchers began rats on a diet including low-dose rapamycin at 19 months old (past middle age in rat years). Rapamycin treatment in daily food continued until the mice were of advanced age -- 34 months old -- almost double the age they were when they started treatment. "Essentially this is as old as these rats can get. These animals were very old but still, blood circulation in the brain was exactly the same as when they started treatment," said study senior author Veronica Galvan, Ph.D., professor of cellular and integrative physiology at UT Health San Antonio" - But it's expensive.  Here's one site I've found.
• Fruit flies live longer with combination drug treatment - Science Daily, 9/30/19 - "lithium as a mood stabiliser, trametinib as a cancer treatment and rapamycin as an immune system regulator ... The three drugs in question act on different proteins of this network to slow the ageing process and delay the onset of age-related death ... Each drug individually extended lifespan by an average of 11%, while pairing two drugs extended lifespan by roughly 30%. When the three drugs were combined, the fruit flies lived 48% longer than flies in a control group that were not given the treatment ... Previous studies in fruit flies have achieved lifespan extensions of about 5-20%, so we found it was quite remarkable that this drug combination enabled them to live 48% longer ... Rapamycin has undesirable effects on fat metabolism, which can be similar to insulin resistance in people, but lithium appeared to cancel out this effect when the two drugs were given together" - See lithium supplements at Amazon.com.
• This pill could make your dog (and maybe you) live longer - CNN, 10/6/16 - "We knew we could go to Mexico and get rapamycin or order it online, but we wanted to be guided by a veterinarian, by a professional ... a month after his stroke, Sherman was so weak, he had to be fed by hand and carried everywhere ... rapamycin changed all that ... The third day after taking rapamycin, he could eat on his own. By the seventh day, he was walking on his own ... Sixteen months later, the dog who had been given two months to live is still alive, and while clearly old, he's still active and able to run around the yard ... The list of things that can go wrong is long and horrifying: cancer, diabetes, infections and more ... Of the 53 patients on the lowest dose of rapamycin, 22 suffered some side effect, most commonly mouth sores ... he prefers to think in terms of treatments that will delay the onset of diseases of aging, such as dementia or heart disease. In mice, rapamycin has been shown to slow these two types of declines, as well as several others"
• Research explains action of drug that may slow aging, related disease - Science Daily, 5/20/14 - "Rapamycin, an antibiotic and immunosuppressant approved for use about 15 years ago, has drawn extensive interest for its apparent ability -- at least in laboratory animal tests -- to emulate the ability of dietary restriction in helping animals to live both longer and healthier ... this medication has some drawbacks, including an increase in insulin resistance that could set the stage for diabetes ... a combination of rapamycin and another drug to offset that increase in insulin resistance might provide the benefits of this medication without the unwanted side effect ... Laboratory mice that have received rapamycin have reduced the age-dependent decline in spontaneous activity, demonstrated more fitness, improved cognition and cardiovascular health, had less cancer and lived substantially longer than mice fed a normal diet ... the drug metformin can address that concern"

Abstracts:

• Towards natural mimetics of metformin and rapamycin - Aging (Albany NY). 2017 Nov 15 - "The analysis revealed many novel candidate metformin and rapamycin mimetics, including allantoin and ginsenoside (metformin), epigallocatechin gallate and isoliquiritigenin (rapamycin), and withaferin A (both)" - [Nutra USA] - See ginseng at Amazon.com and ashwagandha at Amazon.com.  See metformin at the Antiaging Store.
  • Withaferin A - wikipedia.org - "Withaferin A is a steroidal lactone, derived from Acnistus arborescens,[1] Withania somnifera[2] (Indian Winter cherry or Ashwagandha in Sanskrit) and other members of Solanaceae family"