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Anti-aging Research > Astragalus (Astragalus membranaceus)
Astragalus (Astragalus membranaceus)
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Abstracts:
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Astragalus polysaccharide
prevents heart failure-induced cachexia by alleviating excessive adipose
expenditure in white and brown adipose tissue - Lipids Health Dis 2023 Jan
21 - "Astragalus polysaccharide (APS) is a key active
ingredient isolated from Astragalus membranaceus that has been reported to be a
potential treatment for obesity and diabetes by regulating lipid metabolism and
adipogenesis, alleviating inflammation, and improving insulin resistance ... APS
prevented lipolysis and adipose browning in WAT and decreased BAT thermogenesis.
These effects may be related to suppressed sympathetic activity and
inflammation. This study provides a potential approach to treat HF-induced
cardiac cachexia" - See astragalus at Amazon.com.
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Cardiac Cachexia - Kaiser Permanente -
"Cardiac cachexia is unintentional
severe weight loss caused by severe heart failure. The
weight loss might be life-threatening ... Even with a very
good appetite and high calorie intake, some people lose
muscle mass ... Cardiac cachexia can require supplemental
nutrition"
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Hypoglycemic effect of the
polysaccharides from Astragalus membranaceus on type 2 diabetic mice based on
the "gut microbiota-mucosal barrier" - Food Funct 2022 Oct 3 - "Astragalus
membranaceus polysaccharides (APP), the main active constituent, possess
numerous bioactivities ... The results showed that APP improved glycolipid
metabolism disorders, inflammation and oxidative stress levels, and organ injury
in T2DM mice. Furthermore, the APP could protect the intestinal barrier by
suppressing intestinal inflammation and oxidative stress levels, and strongly
inhibited the potential intestinal pathogen Shigella with a reduction rate of
88.92%, and promoted the growth of beneficial bacteria Allobaculum and
Lactobacillus by 11.72% and 30.70%, respectively. In addition, the antibiotic
test indicated that the APP could repair intestinal barrier damage by remodeling
some specific gut microbiota which may be their hypoglycemic mechanism. The
results provide a theoretical basis for the development of APP as a novel
prebiotic in functional food for diabetes" - See
astragalus at Amazon.com.
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Chemical Profiles and
Antiobesity Effect of a Mixture of Astragalus membranaceus and Lithospermum
erythrorhizon Extract in High Fat Diet Fed Mice - Evid Based Complement
Alternat Med 2022 Aug 12 - "The present study aimed to
evaluate the antiobesity potential and synergistic effects of ALM16, a mixture
of Astragalus membranaceus (AM) and Lithospermum erythrorhizon (LE) extracts, in
HFD-induced obese mice. C57BL/6 mice were fed a normal diet (ND), high-fat diet
(HFD), HFD + AM, HFD + LE or HFD + ALM16 (50, 100, and 200 mg/kg) daily for 5
weeks. Compared to the ND group, HFD-fed mice showed significant increases in
body weight, food efficiency ratio, weights of white adipose tissues, adipocytes
size, liver weight, and hepatic steatosis grade. However, ALM16 significantly
reduced those increases induced by HFD. Moreover, as compared to the HFD group,
the ALM16 group significantly ameliorated serum levels of lipid profiles (TG,
TC, HDL, and LDL), adipokines (leptin and adiponectin), and liver damage markers
(AST and ALT levels). Notably, ALM16 was more effective than AM or LE alone and
had a similar or more potent effect than Garcinia cambogia extracts, as a
positive control, at the same dose. These results demonstrate that ALM16
synergistically exerts anti-obesity effects based on complementary interactions
between each component. Also, metabolic profiling between each extract and the
ALM16 was confirmed by UPLC-QTOF/MS, and the difference was confirmed by
relative quantification" - See
Astragalus at Amazon.com.
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Protective effect of
Astragalus membranaceus and Astragaloside IV in sepsis-induced acute kidney
injury - Aging (Albany NY) 2022 Jul 20 - "Acute
kidney injury (AKI) is the most common target organ damage in sepsis.
Sepsis-associated AKI (SA-AKI) may be characterized by damage to the renal
tubular epithelium ... Astragalus membranaceus and AS-IV protect against
sepsis-induced kidney tubular injury by activating the PI3K/AKT pathway"
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Calycosin Improves
Intestinal Mucosal Barrier Function after Gastrectomy in Rats through
Alleviating Bacterial Translocation, Inflammation, and Oxidative Stress -
Evid Based Complement Alternat Med 2022 Jun 26 -
"Calycosin is the main bioactive extract of Astragali Radix with
anti-inflammation, antioxidant, and anticancer properties. Here, our study
evaluated the protective effects and mechanisms of calycosin on intestinal
mucosal barrier under gastrectomy ... Altogether, our findings demonstrate that
calycosin may improve intestinal mucosal barrier function under gastrectomy via
reducing bacterial translocation, inflammation, and oxidative stress"
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Calycosin
- Wikipedia - "Calycosin is an O-methylated
isoflavone. It can be isolated from Astragalus membranaceus
Bge. var. mongholicus[1] and Trifolium pratense L. (red
clover)"
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Astragalus mongholicus
polysaccharides ameliorate hepatic lipid accumulation and inflammation as well
as modulate gut microbiota in NAFLD rats - Food Funct 2022 Jun 21 -
"Hepatic lipid accumulation, inflammation and gut
microbiota dysbiosis are hallmarks of non-alcoholic fatty liver disease (NAFLD),
which is the leading cause of chronic liver disease with no therapeutic
consensus ... Astragalus mongholicus polysaccharides (mAPS) ... mAPS and
Berberine treatment markedly reduced HFD-induced hepatic lipid accumulation ...
mAPS supplementation ameliorates hepatic inflammation and lipid accumulation in
NAFLD by modulating the gut microbiota and SCFA-GPR signaling pathways. The
present study provides new evidence for mAPS as a natural active substance in
the treatment of NAFLD" - See
Astragalus at Amazon.com.
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ZhenQi FuZheng formula
inhibits the growth of colorectal tumors by modulating intestinal microflora-mediated
immune function - Aging (Albany NY) 2022 Jun 8 - "Zhenqi
Fuzheng formula (ZQFZ), of which the main ingredients are Astragalus
membranaceus and Ligustrum lucidum, has immune system regulatory functions and
potential anti-tumor bioactivity ... ZQFZ promoted an anti-tumor immune response
and inhibited the occurrence and development of CRC by regulating the immune
system. This study provides the experimental basis for the application of ZQFZ
as a therapeutic agent for CRC" - See
Astragalus membranaceus
at Amazon.com and Ligustrum lucidum at
Amazon.com.
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Exploring the Mechanism of
Astragalus propinquus Schischkin and Panax Notoginseng (A&P) Compounds in the
Treatment of Renal Fibrosis and Chronic Kidney Disease Based on Integrated
Network Analysis - Evid Based Complement Alternat Med 2022 Feb 27 -
"Astragalus propinquus Schischkin and Panax notoginseng
(A&P) has been widely used in clinical practice to treat chronic kidney disease
(CKD) for many years and achieved a remarkable improvement of these outcomes ...
What's more, the effect of A&P and potential genes was furthermore verified by
using unilateral ureteral ligation (UUO) in rodent model. The results showed
that the expression of HSF1 and RELA both at transcript and protein level was
significantly upregulated in UUO model, but the expression was markedly reversed
after A&P intervention. To further guide the interpretation of active
ingredients from A&P on the effect of HSF1 and RELA, we performed a molecular
docking assay and the results showed that active ingredients such as coptisine
docked well into HSF1 and RELA. In total, these results suggest that A&P may
improve RF in CKD by regulating HSF1 and RELA, which provides a basis for
further understanding the mechanism of A&P in the treatment of RF and CKD"
- See astragalus at Amazon.com and
Panax ginseng
at Amazon.com.
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Astragalus Flavone Induces
Proliferation and Differentiation of Neural Stem Cells in a Cerebral Infarction
Model - Med Sci Monit 2022 Mar 7 - "Ischemic
cerebrovascular disease leads to the activation and differentiation of neural
stem cells (NSCs) into mature neurons and glia cells to repair nerve damage.
Astragalus flavone (ASF) has shown its potential role in proliferation and
differentiation into dopamine neurons of NSCs ... ASF therapy can improve the
neurologic functions and reduce the cerebral infarction volume in a cerebral
infarction model. Moreover, ASF promoted the proliferation of NSCs and induced
differentiation into neurons and oligodendrocytes, which might be involved in
regulating factors in Notch signaling"
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Standardized astragalus
extract for attenuation of the immunosuppression induced by strenuous physical
exercise: randomized controlled trial - J Int Soc Sports Nutr 2021 Jul 16 -
"This paper aimed to verify how a supplementation of
rower's diet with Astragalus Membranaceus Root (AMR) modulated their immune
system response to maximal physical exertion ... 18 members of the Polish Rowing
Team assigned to the supplemented group (n = 10), and the placebo group (n = 8).
The participants performed a 2000 m test on a rowing ergometer at the beginning
and at the end of the six-week of intensive training camp during which the
supplemented group received 500 mg of AMR ... AMR restored the immunological
balance in strenuously trained athlets through a stabilization of NK and Treg
cells with a positive trend in Tδγ towards Th1 response during restitution by
cytokine IL2 modulation"
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Protective Effect of a
Mixture of Astragalus membranaceus and Lithospermum erythrorhizon Extract
against Hepatic Steatosis in High Fat Diet-Induced Nonalcoholic Fatty Liver
Disease Mice - Evid Based Complement Alternat Med. 2020 Mar 19 -
"The present study aimed to evaluate the potential
synergistic and protective effects of ALM16, a mixture of Astragalus
membranaceus (AM) and Lithospermum erythrorhizon (LE) extract in a ratio of
7 : 3, against hepatic steatosis in high fat diet (HFD)-induced nonalcoholic
fatty liver disease (NAFLD) mice. Forty-eight mice were randomly divided
into eight groups and orally administered daily for 6 weeks with a normal
diet (ND) or high fat diet alone (HFD), HFD with AM (HFD + 100 mg/kg AM
extract), HFD with LE (HFD + 100 mg/kg LE extract), HFD with ALM16
(HFD + 50, 100, and 200 mg/kg ALM16), or HFD with MT (HFD + 100 mg/kg Milk
thistle extract) as a positive control. ALM16 significantly decreased the
body and liver weight, serum and hepatic lipid profiles, including
triglyceride (TG), total cholesterol (TC), high-density
lipoprotein-cholesterol (HDL), and low-density lipoprotein-cholesterol
(LDL), and serum glucose levels, compared to the HFD group. Moreover, ALM16
significantly ameliorated the HFD-induced increased hepatic injury markers,
including aspartate aminotransferase (AST), alanine aminotransferase (ALT),
alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and gamma-glutamyltransferase
(GGT)-1. Furthermore, as compared to the mice fed HFD alone, ALM16 increased
the levels of phosphorylated AMP-activated protein kinase (p-AMPK) and
acetyl-CoA carboxylase (p-ACC), thereby upregulating the expression of
carnitine palmitoyltransferase (CPT)-1 and downregulating the expression of
sterol regulatory element-binding protein (SREBP)-1c and fatty acid synthase
(FAS)" - See Astragalus at
Amazon.com and Lithospermum
erythrorhizon at Amazon.com.
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