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Home > Anti-aging Research > NADH

Nicotinamide adenine dinucleotide (NADH)

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News & Research:

  • What’s the Difference Between NAD+ and NADH? - Elysiumhealth.com - "When NAD+ is converted to NADH, it gains two things: First, a charged hydrogen molecule (H+) and next, two electrons. As electrons are negatively charged, the combination of the positively charged NAD+ and H+, coupled with two electrons, effectively cancel each other out and neutralize the resulting NADH molecule. This is why NADH does not have a "+" sign next to it. The charge of a molecule informs how it interacts with other molecules. For example, NADH can’t do what NAD+ does, and vice versa."
  • NMN and NR: How These NAD+ Precursors Measure Up - elysiumhealth.com - "NMN is a precursor to NAD+, or nicotinamide adenine dinucleotide, meaning it becomes NAD+ through a series of chemical transformations ... However, NMN is like a large bed that movers are trying to get through a door: It doesn’t enter the cell easily. One way for NMN to enter the cell is for it to chemically transform into another molecule (called nicotinamide riboside, or NR) before it can enter the cell. NR has earned a name for itself as a highly efficient precursor to NAD+ and can enter the cell as is. NMN, meanwhile, sometimes becomes NR before entering the cell, where it chemically transforms back to NMN and then ultimately becomes NAD+"
  • Vitamin supplement successfully prevents noise-induced hearing loss - Science Daily, 12/2/14 - "the researchers used the chemical nicotinamide riboside (NR) to protect the nerves that innervate the cochlea ... NR was successful at preventing damage to the synaptic connections, avoiding both short-term and long-term hearing loss. What's more, NR was equally effective regardless of whether it was given before or after the noise exposure ... The researchers chose NR because it is a precursor to the chemical compound nicotinamide adenine dinucleotide (NAD+), which had previously been shown by Dr. Brown and co-senior author Samie Jaffrey, MD, PhD, to protect cochlea nerve cells from injury. However, NAD+ is an unstable compound, calling into question whether it could be used out of the petri dish and in a live animal ... Beyond just preventing hearing loss, the researchers think the results may have broader applications because of the underlying way NR protects nerve cells ... The success of this study suggests that targeting SIRT3 using NR could be a viable target for treating all sorts of aging-related disorders--not only hearing loss but also metabolic syndromes like obesity, pulmonary hypertension, and even diabetes" - See nicotinamide adenine dinucleotide at Amazon.com and nicotinamide riboside at Amazon.com.
  • Derivative of vitamin B3 prevents liver cancer in mice - Science Daily, 11/20/14 - "nicotinamide adenine dinucleotide (NAD+) ... When the scientists supplemented the diet in genetically modified mice with nicotinamide riboside, a derivative of vitamin B3 that increases intracellular levels of NAD+, they did not observe tumour development. Surprisingly, when they gave this diet to mice that had already developed the disease, the size of the tumours was reduced and they eventually disappeared" - See nicotinamide adenine dinucleotide at Amazon.com and nicotinamide riboside at Amazon.com.
  • Novel Vitamin Discovery Offers Clues For Cancer Chemotherapy And Lipid Disorders - Science Daily, 5/14/04
  • Energy to Burn - Men's Health/WebMD, 9/1/03
  • Nodding Off? 'Wake-Up Pills' Available - WebMD, 1/16/02 - "Despite feeling sleepy, those taking ENADAlert still performed better than those who took the placebo. "They performed better in terms of performance efficiency -- they had higher numbers of correct answers per minute,""
  • The Wizard is Oz - Life Extension Magazine, 11/01 - "Best-selling author and nutritional guru to the rich and famous, Oz Garcia is singing the praises of the Life Extension Foundation and its products in his newest book, The Healthy High Tech Body, published in September 2001 ... Supplements at the top of Garcia's list of recommendations ... DHA ... NADH ... Alpah Lipoic Acid ... Acetyl-L-Carnitine ... An expanded list of his recommendations includes lycopene, gamma tocopherol, vinpocetine, SAMe, folic acid, carnosine, glutathione, DMAE, Huperzine A, probiotics, MSM, secretagogues, arginine pyroglutamate, IP-6, bioflavonoid formulas and grape skin/seed extracts"
  • Parkinson's Defense - Nutrition Science News, 5/01
  • NADH, the supervitamin body and mind energizer - by James South MA - "The Birkmayers also found increased urinary excretion of dopamine metabolites in the patients, indicating there was an actual NADH induced increase in dopamine production"
  • Enada Reduces Chronic Fatigue Symptoms - Nutrition Science News, 8/99

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