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Home > Anti-aging Research > Antidepressants > 5-hydroxytryptophan (5-HTP)

5-hydroxytryptophan (5-HTP)

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  • Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis - Nutr Rev. 2020 Jan 1 - "Analyses revealed a depression remission rate of 0.65 (95% confidence interval [CI], 0.55-0.78; remission rate [k] = 13), and this was confirmed by the questionnaire results, which revealed a large Hedges' g (1.11; 95%CI, 0.53-1.69). Methodological variability (in treatment duration, type of depression studied, experimental design, 5-hydroxytryptophan dosage) contributes to heterogeneity in the results (I2 = 76%, τ2 = 0.379). In addition, the OHAT (Office of Health Assessment and Translation risk of bias rating) tool suggested that, on the whole, current studies are relatively weak (few include placebo groups)" - See 5-HTP products at Amazon.com.